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TR 388 Rat Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Battelle Columbus                                         DATE: 09/09/94   
EXP: 05076                    ETHYLENETHIOUREA                 TIME: 21:06:18   
TEST: 01              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: 03372    
CONT: N01ES82151                                               CAS: 96-45-7     
PATHOLOGIST: J. TOFT                         S. EUSTIS                          
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Battelle Columbus                                         DATE: 09/09/94  
EXP: 05076                    ETHYLENETHIOUREA                 TIME: 21:06:18  
TEST: 01              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: 03372   
CONT: N01ES82151                                               CAS: 96-45-7    
PATHOLOGIST: J. TOFT                         S. EUSTIS                         

                                 ETHYLENETHIOUREA


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM   0-0                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 31     CENSORED DEATHS 0    TERMINAL 19        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      155   307   372   472   472   507   512   517   520   586                 |
 |      592   597   615   619   628   628   633   633   643   647                 |
 |      674   676   692   696   698   701   702   709   712   719                 |
 |      726                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0 PPM   10-0                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 32     CENSORED DEATHS 0    TERMINAL 18        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      416   435   501   507   538   552   552   571   577   587                 |
 |      603   605   622   633   636   640   650   650   671   677                 |
 |      678   689   692   698   707   710   711   712   712   718                 |
 |      720   720                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 25 PPM   1-1                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 28     CENSORED DEATHS 0    TERMINAL 22        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      230   368   382   395   444   497   536   565   580   611                 |
 |      626   642   642   646   657   660   671   674   691   692                 |
 |      696   697   703   705   705   710   720   728                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                 ETHYLENETHIOUREA


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 83 PPM   0-3                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 33     CENSORED DEATHS 0    TERMINAL 17        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      183   276   381   395   453   479   486   503   503   522                 |
 |      565   585   590   592   603   605   612   622   628   632                 |
 |      653   657   661   664   678   678   695   710   713   713                 |
 |      726   732   732                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 83 PPM   3-3                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 30     CENSORED DEATHS 0    TERMINAL 20        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      42    447   453   466   541   594   596   597   603   615                 |
 |      617   618   619   632   634   640   643   647   650   653                 |
 |      670   671   678   678   696   696   698   708   710   724                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 83 PPM   10-3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 35     CENSORED DEATHS 0    TERMINAL 15        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      371   429   493   507   536   538   552   552   599   599                 |
 |      601   615   626   640   640   642   643   647   647   657                 |
 |      661   678   678   678   681   687   692   692   697   701                 |
 |      705   708   709   713   713                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                 ETHYLENETHIOUREA


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 250 PPM   0-10                                 |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 31     CENSORED DEATHS 5    TERMINAL 14        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      391   461   478   523   529   579   580   580   596   597                 |
 |      603   611   631   632   639   640   650   650   657   664                 |
 |      677   677   687   689   695   697   712   719   722   724                 |
 |      728                                                                       |
 |  CENSORED DEATHS                                                               |
 |      30    30    30    30    30                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 250 PPM  10-10                                 |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 44     CENSORED DEATHS 0    TERMINAL 6         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      418   438   486   506   521   527   528   538   544   555                 |
 |      576   583   585   597   598   598   604   618   618   618                 |
 |      619   620   634   634   636   640   640   642   646   654                 |
 |      654   654   657   658   671   682   698   712   713   713                 |
 |      723   723   724   732                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                 ETHYLENETHIOUREA


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   733 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM   0-0|   100.0  98.0  98.0  96.0  94.0  90.0  82.0  76.0  60.0  38.0      |
 |           |                                                                    |
 |           |                                                                    |
 |0          |   100.0 100.0 100.0 100.0  98.0  96.0  90.0  76.0  64.0  36.0      |
 |PPM   10-0 |                                                                    |
 |           |                                                                    |
 |25         |   100.0 100.0  98.0  98.0  92.0  90.0  86.0  82.0  68.0  44.0      |
 |PPM   1-1  |                                                                    |
 |           |                                                                    |
 |83         |   100.0 100.0  98.0  96.0  92.0  88.0  80.0  68.0  52.0  34.0      |
 |PPM   0-3  |                                                                    |
 |           |                                                                    |
 |83         |    98.0  98.0  98.0  98.0  98.0  92.0  90.0  82.0  60.0  40.0      |
 |PPM   3-3  |                                                                    |
 |           |                                                                    |
 |83         |   100.0 100.0 100.0 100.0  98.0  96.0  88.0  78.0  58.0  30.0      |
 |PPM   10-3 |                                                                    |
 |           |                                                                    |
 |250        |   100.0 100.0 100.0 100.0  97.8  93.3  88.9  75.6  55.6  31.1      |
 |PPM   0-10 |                                                                    |
 |           |                                                                    |
 |250        |   100.0 100.0 100.0 100.0  98.0  96.0  82.0  66.0  32.0  12.0      |
 |PPM  10-10 |                                                                    |
 |           |                                                                    |
 ==================================================================================

                                 ETHYLENETHIOUREA


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS


 ===============================================================================================================================
 |                                               SURVIVAL SUMMARY STATISTICS                                                   |
 |                                                                                                                             |
 |                                                                                                                             |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |                                                                        DOSE                                                 |
 |                                                                                                                             |
 |                                0 PPM   0-0 0           25          83          83          83          250         250      |
 |                                            PPM   10-0  PPM   1-1   PPM   0-3   PPM   3-3   PPM   10-3  PPM   0-10  PPM  10-1|
 |-----------------------------------------------------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       38.0%       36.0%       44.0%       34.0%       40.0%       30.0%       31.1%       12.0%    |
 |(KAPLAN-MEIER)          |                                                                                                    |
 |                        |                                                                                                    |
 |SIGNIFICANCE (B)        |       P=0.004      -----      P=0.555N    P=0.732     P=0.917N    P=0.644     P=0.735     P=0.009  |
 |(LIFE TABLE)            |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN DAY OF             |       592.3       627.8       602.6       582.6       607.9       626.5       626.4       616.7    |
 |NATURAL DEATHS (C)      |       (23.6)      (14.9)      (24.5)      (23.0)      (23.5)      (14.1)      (14.9)      (11.4)   |
 |(STANDARD ERROR)        |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN LIFE SPAN (D)      |       645.7       665.7       660.0       633.8       657.9       658.4       596.6       630.7    |
 |(STANDARD ERROR)        |       (17.5)      (11.9)      (16.5)      (18.2)      (16.5)      (12.1)      (29.3)      (11.4)   |
 |                        |                                                                                                    |
 ===============================================================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                 ETHYLENETHIOUREA


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 740 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM   0-0                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 26     CENSORED DEATHS 0    TERMINAL 24        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      424   466   494   508   523   526   538   544   547   559                 |
 |      561   561   594   624   642   654   657   658   667   694                 |
 |      707   718   718   721   721   726                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0 PPM   10-0                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 20     CENSORED DEATHS 0    TERMINAL 30        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      236   431   480   488   494   528   592   592   609   658                 |
 |      668   674   683   690   694   704   706   712   713   721                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 25 PPM  1-1                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 0    TERMINAL 34        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      447   511   523   557   581   606   610   636   652   679                 |
 |      696   699   700   705   721   735                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                 ETHYLENETHIOUREA


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 740 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 83 PPM   0-3                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 17     CENSORED DEATHS 0    TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      372   461   497   587   603   604   637   638   638   654                 |
 |      665   669   671   711   718   726   732                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 83 PPM   3-3                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 23     CENSORED DEATHS 0    TERMINAL 27        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      312   431   494   501   574   585   587   597   605   622                 |
 |      637   638   651   659   665   677   683   685   694   698                 |
 |      712   713   738                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 83 PPM   10-3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 17     CENSORED DEATHS 0    TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      437   494   550   558   564   590   642   657   687   694                 |
 |      704   706   712   720   721   725   725                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                 ETHYLENETHIOUREA


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 740 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 250 PPM   0-10                                 |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 30     CENSORED DEATHS 0    TERMINAL 20        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      487   547   570   573   588   592   601   605   613   621                 |
 |      628   638   657   660   666   676   677   679   684   690                 |
 |      694   694   698   707   717   726   726   726   726   734                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 250 PPM   10-10                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 36     CENSORED DEATHS 0    TERMINAL 14        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      462   469   538   544   548   564   565   565   573   576                 |
 |      592   592   598   600   606   607   614   614   620   620                 |
 |      624   637   638   642   642   676   679   679   684   689                 |
 |      694   707   707   713   713   715                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                 ETHYLENETHIOUREA


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 740 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   740 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM   0-0|   100.0 100.0 100.0 100.0  98.0  96.0  84.0  74.0  64.0  48.0      |
 |           |                                                                    |
 |           |                                                                    |
 |0          |   100.0 100.0  98.0  98.0  98.0  94.0  88.0  84.0  80.0  60.0      |
 |PPM   10-0 |                                                                    |
 |           |                                                                    |
 |25 PPM  1-1|   100.0 100.0 100.0 100.0 100.0  98.0  94.0  90.0  82.0  68.0      |
 |           |                                                                    |
 |           |                                                                    |
 |83         |   100.0 100.0 100.0 100.0  98.0  96.0  94.0  88.0  78.0  66.0      |
 |PPM   0-3  |                                                                    |
 |           |                                                                    |
 |83         |   100.0 100.0 100.0  98.0  98.0  96.0  92.0  82.0  70.0  54.0      |
 |PPM   3-3  |                                                                    |
 |           |                                                                    |
 |83         |   100.0 100.0 100.0 100.0 100.0  98.0  96.0  88.0  84.0  66.0      |
 |PPM   10-3 |                                                                    |
 |           |                                                                    |
 |250        |   100.0 100.0 100.0 100.0 100.0 100.0  98.0  84.0  72.0  40.0      |
 |PPM   0-10 |                                                                    |
 |           |                                                                    |
 |250        |   100.0 100.0 100.0 100.0 100.0  96.0  92.0  72.0  50.0  28.0      |
 |PPM   10-10|                                                                    |
 |           |                                                                    |
 ==================================================================================

                                 ETHYLENETHIOUREA


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 740 DAYS


 ===============================================================================================================================
 |                                               SURVIVAL SUMMARY STATISTICS                                                   |
 |                                                                                                                             |
 |                                                                                                                             |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |                                                                        DOSE                                                 |
 |                                                                                                                             |
 |                                0 PPM   0-0 0           25 PPM  1-1 83          83          83          250         250      |
 |                                            PPM   10-0              PPM   0-3   PPM   3-3   PPM   10-3  PPM   0-10  PPM   10-|0
 |-----------------------------------------------------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       48.0%       60.0%       68.0%       66.0%       54.0%       66.0%       40.0%       28.0%    |
 |(KAPLAN-MEIER)          |                                                                                                    |
 |                        |                                                                                                    |
 |SIGNIFICANCE (B)        |       P<0.001      -----      P=0.052N    P=0.080N    P=0.604N    P=0.065N    P=0.849     P=0.069  |
 |(LIFE TABLE)            |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN DAY OF             |       605.8       603.7       628.6       622.5       615.6       640.4       653.3       619.6    |
 |NATURAL DEATHS (C)      |       (17.7)      (28.3)      (21.4)      (23.8)      (21.1)      (22.0)      (11.4)      (10.9)   |
 |(STANDARD ERROR)        |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN LIFE SPAN (D)      |       670.2       685.5       704.4       700.1       682.8       706.1       688.0       653.3    |
 |(STANDARD ERROR)        |       (13.2)      (14.7)      (10.0)      (11.2)      (13.0)      (10.0)      ( 9.1)      (11.0)   |
 |                        |                                                                                                    |
 ===============================================================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                          ETHYLENETHIOUREA
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM   0-0      = 1
                                                        0 PPM   10-0     = 2
                                                        25 PPM   1-1     = 3
                                                        83 PPM   0-3     = 4
                                                        83 PPM   3-3     = 5
                                                        83 PPM   10-3    = 6
                                                        250 PPM   0-10   = 7
                                                        250 PPM  10-10   = 8

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
  100 + 1      5                 1    4     3                     6   7   2
      |        5                 1    4     3       4   1         3   7   2 625  7
      |                                             4   1         31 3 3    625 575178622
      |                                                                3      3 4 5 7   2  7 25
   90 +                                                                       3 4  14 3 1  77252   7  5
      |                                                                             443 11   3 6      55
      |                                                                              4 4 1 18382 322   55
      |                                                                                4   1  8 8  21  753
   80 +                                                                                    4    84 81 1 2353
      |                                                                                          4 84 1176 3 3
P     |                                                                                             4 412116233
E     |                                                                                               4 47117 33
R  70 +                                                                                                     22 3 3
C     |                                                                                                844 1122  33
E     |                                                                                                 8444112   23 3
N     |                                                                                                    44115  22
T  60 +                                                                                                     4 14 651 33
      |                                                                                                        7 6 2 2
S     |                                                                                                   8 8  4 451 113
U     |                                                                                                          4 46 22
R  50 +                                                                                                     88     766112
V     |                                                                                                            4 74 33
I     |                                                                                                      88      641133 3
V     |                                                                                                       88      66115
A  40 +                                                                                                                 411 5
L     |                                                                                                                6671 1
      |                                                                                                                  2  2
      |                                                                                                        8  8
   30 +                                                                                                           8 8   6 7 6
      |                                                                                                             8 8
      |                                                                                                               8 8
      |
   20 +                                                                                                                 8 8
      |
      |                                                                                                                   8 8
      |                                                                                                                     8
   10 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 119 obs hidden.

                                                          ETHYLENETHIOUREA
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM   0-0      = 1
                                                        0 PPM   10-0     = 2
                                                        25 PPM  1-1      = 3
                                                        83 PPM   0-3     = 4
                                                        83 PPM   3-3     = 5
                                                        83 PPM   10-3    = 6
                                                        250 PPM   0-10   = 7
                                                        250 PPM   10-10  = 8

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                    2            5        4       1 63  8   7
      |                                      2            5        4       1263  41  76 3      7
      |                                                                     2    41 22151  3 8863 7 4
      |                                                                              2251  1  8836534   4
   90 +                                                                               2    11  8 6535 6 3
      |                                                                                     11        2733  46
      |                                                                                      111 88 5 2523  34 3     6
      |                                                                                        11 88    275  4 2   3 66
P  80 +                                                                                         11 8  8   575  2 423  36
E     |                                                                                                    755   422
R     |                                                                                          1    18   1 557 542223346
C     |                                                                                                88  1 1   77  22343
E  70 +                                                                                                      1 1 575  22 34 3
N     |                                                                                                 88         55     4 33
T     |                                                                                                  88    1  175 522 6 44
      |                                                                                                           1 771 22
S  60 +                                                                                                   88         71152   2
U     |                                                                                                    88          1 1
R     |                                                                                                     88        775    5
V     |                                                                                                                7 7
I  50 +                                                                                                      8     8     11
V     |                                                                                                                   1  1
A     |                                                                                                            88
L     |                                                                                                             88    7 7
   40 +                                                                                                              88     77
      |                                                                                                               88
      |                                                                                                                88
      |
   30 +                                                                                                                 88
      |                                                                                                                  8   8
      |
      |
   20 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 80 obs hidden.

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