National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3772

TR 389 Rat Pathology Tables

NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97
Route: GAVAGE                                                                                                     Time: 17:43:14




       Facility:  Microbiological Associates

       Chemical CAS #:  26628228

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 9| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 9| 8| 4| 2| 3| 3| 3| 3| 6| 3| 3| 3| 0| 9|             
                                           | 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 3| 0| 9| 9| 7| 7| 7| 7| 9| 7| 7| 7| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 G/KG                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    VEHICLEF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              2                           |             
      Basophilic Focus                     |                2                                                         |             
      Basophilic Focus, Multifocal         |    2  2           2     2     2                    2  2        4  2      |             
      Congestion                           |                                                                          |             
      Fatty Change, Diffuse                |          2                                                               |             
      Fatty Change, Focal                  |    2  2                                                                  |             
      Fatty Change, Multifocal             |                      2                                   2               |             
      Hematopoietic Cell Proliferation     |                                                                         1|             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia, Multifocal, Nodular     |          3                                                               |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                   1                                                      |             
      Inflammation, Granulomatous          |    2                                                                     |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                1     2        2     1     1        1  2        1         |             
      Leukocytosis                         |       3     2                                                     2      |             
      Necrosis, Focal                      |                                     2                                    |             
      Necrosis, Multifocal                 |                                        2                                 |             
      Bile Duct, Hyperplasia               |          2     1        2  1  1  2  1  1     2  2  1     1  1  2         |             
      Centrilobular, Fatty Change          |                                           2                              |             
      Centrilobular, Necrosis              |                                                                         2|             
      Hepatocyte, Periportal, Necrosis     |                                                                          |             
      Periportal, Fatty Change             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +        +     +  +           +     +        +      |             
      Fat, Necrosis, Focal                 |                      4        4     4  4           4     3        4      |             
      Fat, Necrosis, Multifocal            |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                                                          |             
      Acinus, Atrophy                      |                   1  1           2              1                        |             
      Acinus, Cytoplasmic Alteration,      |                                                                          |             
          Multifocal                       |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 9| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 9| 8| 4| 2| 3| 3| 3| 3| 6| 3| 3| 3| 0| 9|             
                                           | 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 3| 0| 9| 9| 7| 7| 7| 7| 9| 7| 7| 7| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 G/KG                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    VEHICLEF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                       2                  |             
      Inflammation, Chronic                |                                                       2  2               |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia, Focal       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |       1  1     1  2     1  2     1     1  1  2  1     2     2  2  2  1  1|             
      Erosion                              |                                                                         1|             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Chronic Active, Focal  |                   2                                                      |             
                                            __________________________________________________________________________|             
   Tongue                                  |       +                                                                  |             
                                            __________________________________________________________________________|             
   Tooth                                   |                   +                                                      |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic Active                  |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2           3        2     2     1              2           1         |             
      Aortic Valve, Inflammation, Subacute |                                                                          |             
      Myocardium, Atrium Right, Necrosis   |                                                                          |             
      Myocardium, Ventricle, Necrosis      |                                                                          |             
      Pericardium, Inflammation,           |                                                                          |             
          Necrotizing                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                  X                                       |             
      Angiectasis                          |    2                                                        3     1      |             
      Degeneration, Ballooning, Focal      |                   2                                                      |             
      Hyperplasia, Focal                   |                   2  2                                2           1      |             
      Hyperplasia, Multifocal              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Necrosis, Multifocal                 |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Vacuolization Cytoplasmic            |                                     3                                    |             
      Vacuolization Cytoplasmic, Multifocal|       2                                                                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Angiectasis                          |    2                                                                     |             
      Hyperplasia, Focal                   |                               2                                          |             
      Hyperplasia, Multifocal              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 9| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 9| 8| 4| 2| 3| 3| 3| 3| 6| 3| 3| 3| 0| 9|             
                                           | 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 3| 0| 9| 9| 7| 7| 7| 7| 9| 7| 7| 7| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 G/KG                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    VEHICLEF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  M  M  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2                    3     2                    3        2  2  2      |             
      Cyst                                 |                                                                      X  X|             
      Pigmentation, Hemosiderin            |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    | 2  2                    2                                         2      |             
      Pars Distalis, Hyperplasia           |       3                                            3                     |             
      Pars Nervosa, Hyperplasia            |                2                                                         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                         2           1  2     2     1                     |             
      Follicle, Cyst                       |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Duct, Ectasia                        |                                                             3           3|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                            X                                             |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cervix, Cyst                         | X                             X  X                                       |             
      Cervix, Inflammation, Chronic Active |                                                                          |             
      Cervix, Inflammation, Suppurative    |                                                                          |             
      Endometrium, Cyst                    |                                              X                           |             
      Endometrium, Cyst, Multiple          |                                                                      X   |             
      Endometrium, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Hemorrhage              | 3                    2  2           2     2              2               |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Inflammation,           |                                                                          |             
          Granulomatous                    |    2                                                                     |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                      2              2     2                              |             
      Mediastinal, Sinus, Ectasia          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 9| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 9| 8| 4| 2| 3| 3| 3| 3| 6| 3| 3| 3| 0| 9|             
                                           | 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 3| 0| 9| 9| 7| 7| 7| 7| 9| 7| 7| 7| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 G/KG                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    VEHICLEF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mesenteric, Hemorrhage               |       2                                                                  |             
      Mesenteric, Sinus, Ectasia           |                            2  2                                          |             
      Pancreatic, Hemorrhage               |                2                                                         |             
      Pancreatic, Pigmentation, Hemosiderin|                2                                                  2      |             
      Pancreatic, Sinus, Ectasia           |                                              2                           |             
      Renal, Pigmentation, Hemosiderin     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Inflammation, Granulomatous          |    2                                                                     |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |             X                                                            |             
      Fibrosis, Focal                      |                                              2                           |             
      Hematopoietic Cell Proliferation     |             3                                                           4|             
      Inflammation, Granulomatous          |    4                                                                     |             
      Necrosis                             |          4                                                           3   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  M  +  M  +  M  +  +  +  M  M  +  M  +  M  +  +  +|             
      Congestion                           |                                                                          |             
      Ectopic Tissue                       |                                                                          |             
      Hemorrhage                           | 2                                                                        |             
      Epithelial Cell, Hyperplasia         | 2  2  2  2  1  2     2     2     2     1  2  2        2     2     2  2   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |    X              X                                                      |             
      Hyperplasia, Multifocal, Nodular     |                                        2                                 |             
      Inflammation, Chronic Active         |                                     4                                    |             
      Duct, Ectasia                        |                   2        4              4                              |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                        3                                 |             
      Necrosis, Focal                      |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 9| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 9| 8| 4| 2| 3| 3| 3| 3| 6| 3| 3| 3| 0| 9|             
                                           | 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 3| 0| 9| 9| 7| 7| 7| 7| 9| 7| 7| 7| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 G/KG                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    VEHICLEF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Congestion                           | 3                                                                        |             
      Hemorrhage                           |                   1                                      2               |             
      Infiltration Cellular, Histiocyte    |    1  1  1     1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                             1            |             
      Leukocytosis                         |             3                                                            |             
      Necrosis, Multifocal                 |                                                                          |             
      Pigmentation                         |    1  1  1     1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                              2                           |             
      Alveolar Epithelium, Hyperplasia     |                3                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation                         |                                                                          |             
      Inflammation, Suppurative            |          2                                                  2            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +  +                              |             
      Cataract                             |                                                                          |             
      Necrosis                             |                                                                          |             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Suppurative                      |                                        3                                 |             
      Retina, Degeneration                 |                                                                          |             
      Sclera, Metaplasia, Osseous          |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                           +                              |             
      Infiltration Cellular, Lymphocyte    |                                           2                              |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Concretion                           |                                                 2                        |             
      Cyst                                 |                                                                          |             
      Hydronephrosis                       |                                                                   2      |             
      Nephropathy                          | 1  2  2  2  1  1  2  2  2  2  1  2  2  1  2  1     2  3  2  2  2  1  1   |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Inflammation, Subacute       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 3| 3| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 4| 3|             
                             DAY ON TEST   | 3| 3| 7| 1| 0| 3| 3| 3| 1| 4| 3| 3| 7| 3| 0| 3| 3| 3| 7| 8| 3| 3| 3| 5| 5|             
                                           | 3| 7| 8| 6| 6| 7| 7| 7| 9| 3| 7| 7| 1| 7| 5| 7| 7| 7| 5| 8| 7| 7| 7| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 G/KG                                 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    VEHICLEF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                          1               |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      3                    2                              |             
      Basophilic Focus                     |                         1                                                |             
      Basophilic Focus, Multifocal         |    2              2           2  2  2  2           2           2         |             
      Congestion                           |                         3                                                |             
      Fatty Change, Diffuse                |                                                                          |             
      Fatty Change, Focal                  |                                     2                                    |             
      Fatty Change, Multifocal             |                                                       2                  |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia, Multifocal, Nodular     |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                    1                     |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                          |             
      Inflammation, Granulomatous          |                2                                                         |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |    1              1  2  1  1        1  1  1  1  1           1  1         |             
      Leukocytosis                         |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Necrosis, Multifocal                 |                                                             2        2   |             
      Bile Duct, Hyperplasia               | 2  1  1     1     2     1  1  2  2     2  2  2     2              2      |             
      Centrilobular, Fatty Change          |                                                                          |             
      Centrilobular, Necrosis              |                                                                          |             
      Hepatocyte, Periportal, Necrosis     |                                                          1               |             
      Periportal, Fatty Change             |                                                          2               |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +           +        +     +        +        +  +  +        +         |             
      Fat, Necrosis, Focal                 |    4           4        4     4        4        3  4  4                  |             
      Fat, Necrosis, Multifocal            |                                                                4         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                                                          |             
      Acinus, Atrophy                      |    2                    1     1  3     2     1  2     4                  |             
      Acinus, Cytoplasmic Alteration,      |                                                                          |             
          Multifocal                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 3| 3| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 4| 3|             
                             DAY ON TEST   | 3| 3| 7| 1| 0| 3| 3| 3| 1| 4| 3| 3| 7| 3| 0| 3| 3| 3| 7| 8| 3| 3| 3| 5| 5|             
                                           | 3| 7| 8| 6| 6| 7| 7| 7| 9| 3| 7| 7| 1| 7| 5| 7| 7| 7| 5| 8| 7| 7| 7| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 G/KG                                 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    VEHICLEF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |                                                       4                  |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |       3                                                                  |             
      Epithelium, Hyperplasia, Focal       |    2                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                      2     1  1  1     1  1  2  2  1  1     1  2  1     1|             
      Erosion                              |                                                                          |             
      Hyperplasia, Focal                   |                                                             2            |             
      Inflammation, Chronic Active, Focal  |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2                    2        1     1  1  1  1        2               |             
      Aortic Valve, Inflammation, Subacute |                                                             1            |             
      Myocardium, Atrium Right, Necrosis   |                                                                          |             
      Myocardium, Ventricle, Necrosis      |                                                                          |             
      Pericardium, Inflammation,           |                                                                          |             
          Necrotizing                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Angiectasis                          | 2                    2                          2                        |             
      Degeneration, Ballooning, Focal      |                                                                          |             
      Hyperplasia, Focal                   |                   2                 2              2        2     2      |             
      Hyperplasia, Multifocal              |                2                                                         |             
      Infiltration Cellular, Lymphocyte    |                                                          1               |             
      Necrosis, Multifocal                 |                                                       3                  |             
      Vacuolization Cytoplasmic, Focal     |             2                                   2              2         |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Vacuolization Cytoplasmic, Multifocal|                                           2                              |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia, Focal                   |                   2                                2                     |             
      Hyperplasia, Multifocal              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 3| 3| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 4| 3|             
                             DAY ON TEST   | 3| 3| 7| 1| 0| 3| 3| 3| 1| 4| 3| 3| 7| 3| 0| 3| 3| 3| 7| 8| 3| 3| 3| 5| 5|             
                                           | 3| 7| 8| 6| 6| 7| 7| 7| 9| 3| 7| 7| 1| 7| 5| 7| 7| 7| 5| 8| 7| 7| 7| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 G/KG                                 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    VEHICLEF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                          1               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                3                                                         |             
      Cyst                                 |       X           X        X           X                                 |             
      Pigmentation, Hemosiderin            |                   2                                                      |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                          3               |             
      Pars Nervosa, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2                                            2                 1         |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  M  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |                                                       4                  |             
      Duct, Ectasia                        |                      2                                4           2      |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cervix, Cyst                         |                                        X        X                 X  X   |             
      Cervix, Inflammation, Chronic Active |                                                          4               |             
      Cervix, Inflammation, Suppurative    |                                                                          |             
      Endometrium, Cyst                    |                                              X                           |             
      Endometrium, Cyst, Multiple          |                                                                          |             
      Endometrium, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Congestion              |                                                                      4   |             
      Mediastinal, Hemorrhage              |                1        2           2              2           2     3   |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                             3            |             
      Mediastinal, Inflammation,           |                                                                          |             
          Granulomatous                    |                2                                                         |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |    2           1        2     2     2                          1         |             
      Mediastinal, Sinus, Ectasia          |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 3| 3| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 4| 3|             
                             DAY ON TEST   | 3| 3| 7| 1| 0| 3| 3| 3| 1| 4| 3| 3| 7| 3| 0| 3| 3| 3| 7| 8| 3| 3| 3| 5| 5|             
                                           | 3| 7| 8| 6| 6| 7| 7| 7| 9| 3| 7| 7| 1| 7| 5| 7| 7| 7| 5| 8| 7| 7| 7| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 G/KG                                 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    VEHICLEF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mesenteric, Hemorrhage               |                                           2                              |             
      Mesenteric, Sinus, Ectasia           |                      2           2                 2           2         |             
      Pancreatic, Hemorrhage               |                                                                          |             
      Pancreatic, Pigmentation, Hemosiderin|                                                                   2      |             
      Pancreatic, Sinus, Ectasia           |                                                                          |             
      Renal, Pigmentation, Hemosiderin     |                                                 2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  M  +  +  +  +  M  +  M  +  +  +  +  I  +  +  +  +  M  +  +  +|             
      Hemorrhage                           |                                                          2               |             
      Hyperplasia, Plasma Cell             |                                                    2     3               |             
      Inflammation, Granulomatous          |                                                                          |             
      Sinus, Ectasia                       |    2                                         2     1                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                                                          |             
      Fibrosis, Focal                      |                                                                   4      |             
      Hematopoietic Cell Proliferation     |                                                          2               |             
      Inflammation, Granulomatous          |                4                                                         |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  M  M  +  M  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +|             
      Congestion                           |                                                                      3   |             
      Ectopic Tissue                       |                                                    X                     |             
      Hemorrhage                           |          2  3                                                            |             
      Epithelial Cell, Hyperplasia         |    2                 2     2  2  2  2  1  2  2  2  2  2     2     2  1  2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                                          |             
      Hyperplasia, Multifocal, Nodular     |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Duct, Ectasia                        |                                  2  3     4        3  4                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hemorrhage                           |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 3| 3| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 4| 3|             
                             DAY ON TEST   | 3| 3| 7| 1| 0| 3| 3| 3| 1| 4| 3| 3| 7| 3| 0| 3| 3| 3| 7| 8| 3| 3| 3| 5| 5|             
                                           | 3| 7| 8| 6| 6| 7| 7| 7| 9| 3| 7| 7| 1| 7| 5| 7| 7| 7| 5| 8| 7| 7| 7| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0 G/KG                                 | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    VEHICLEF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Congestion                           | 3        3  3           3                                                |             
      Hemorrhage                           | 2              2                                                         |             
      Infiltration Cellular, Histiocyte    | 1  1           1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1        1|             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Leukocytosis                         |                                                                          |             
      Necrosis, Multifocal                 |                                                                      4   |             
      Pigmentation                         | 1  1           1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1        1|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                   3      |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                      1                                                   |             
      Inflammation                         |                                                                          |             
      Inflammation, Suppurative            |                      1              2                    1               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +              +              A   |             
      Cataract                             |                                                       3                  |             
      Necrosis                             |                                        4                                 |             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Suppurative                      |                                                                          |             
      Retina, Degeneration                 |                                                       3                  |             
      Sclera, Metaplasia, Osseous          |                                                       2                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                        +                                 |             
      Infiltration Cellular, Lymphocyte    |                                        1                                 |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Concretion                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Nephropathy                          |    2  1  1        2  1  2  2  2  2  2  2  3  2  3  2  1  2  1  1  2     1|             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Inflammation, Subacute       |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 6|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 9| 8|                                            |            |
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 9| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0 G/KG                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    VEHICLEF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Subacute               |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +                                             |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  A  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      3  2.3|
      Basophilic Focus                     |    2           2                                                         |      4  1.8|
      Basophilic Focus, Multifocal         | 2                    2                                                   |     19  2.1|
      Congestion                           |                                                                          |      1  3.0|
      Fatty Change, Diffuse                |                            2                                             |      2  2.0|
      Fatty Change, Focal                  |                                                                          |      3  2.0|
      Fatty Change, Multifocal             |          2                                                               |      4  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hepatodiaphragmatic Nodule           | X                                                                        |      1     |
      Hyperplasia, Multifocal, Nodular     |                                                                          |      1  3.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  1.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  1.0|
      Inflammation, Granulomatous          |                                                                          |      2  2.0|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       | 1  1  1           1                                                      |     24  1.2|
      Leukocytosis                         |       2                                                                  |      4  2.3|
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Necrosis, Multifocal                 |          1                                                               |      4  1.8|
      Bile Duct, Hyperplasia               |    2     2     2     2  2  3                                             |     34  1.6|
      Centrilobular, Fatty Change          |                                                                          |      1  2.0|
      Centrilobular, Necrosis              |             3                                                            |      2  2.5|
      Hepatocyte, Periportal, Necrosis     |                                                                          |      1  1.0|
      Periportal, Fatty Change             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |  16        |
      Fat, Necrosis, Focal                 |                                                                          |     15  3.9|
      Fat, Necrosis, Multifocal            |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 6|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 9| 8|                                            |            |
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 9| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0 G/KG                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    VEHICLEF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ectopic Tissue                       | X                                                                        |      1     |
      Acinus, Atrophy                      |    2  4           3        2                                             |     16  2.0|
      Acinus, Cytoplasmic Alteration,      |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Necrotizing            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Ulcer                                |                                                                          |      1  3.0|
      Epithelium, Hyperplasia, Focal       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Degeneration, Cystic                 | 1  1  1  1     2  2  1     1                                             |     39  1.3|
      Erosion                              |                                                                          |      1  1.0|
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Inflammation, Chronic Active, Focal  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       |    2  1        2        1                                                |     20  1.6|
      Aortic Valve, Inflammation, Subacute |                                                                          |      1  1.0|
      Myocardium, Atrium Right, Necrosis   |             3                                                            |      1  3.0|
      Myocardium, Ventricle, Necrosis      |             2                                                            |      1  2.0|
      Pericardium, Inflammation,           |                                                                          |            |
          Necrotizing                      |             2                                                            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1     |
      Angiectasis                          |                                                                          |      6  2.0|
      Degeneration, Ballooning, Focal      |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |    2  2                    2                                             |     12  1.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 6|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 9| 8|                                            |            |
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 9| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0 G/KG                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    VEHICLEF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Multifocal              |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Necrosis, Multifocal                 |             3                                                            |      2  3.0|
      Vacuolization Cytoplasmic, Focal     |       2  2           2                                                   |      6  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic, Multifocal|                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |                                                                          |      3  2.0|
      Hyperplasia, Multifocal              |                   2        3                                             |      2  2.5|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |       3              3                                                   |     10  2.5|
      Cyst                                 |                X  X  X                                                   |      9     |
      Pigmentation, Hemosiderin            |                2                                                         |      2  2.0|
      Pars Distalis, Hyperplasia, Focal    |                      2                                                   |      5  2.0|
      Pars Distalis, Hyperplasia           |                                                                          |      3  3.0|
      Pars Nervosa, Hyperplasia            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      C-Cell, Hyperplasia                  |                                                                          |      8  1.6|
      Follicle, Cyst                       |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |             +                                                            |   1        |
      Hemorrhage                           |             4                                                            |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  M  +  +  +  +  M  +                                             |  55        |
      Hyperplasia                          |                2                                                         |      1  2.0|
      Inflammation, Chronic Active         |                            2                                             |      2  3.0|
      Duct, Ectasia                        |                                                                          |      5  2.8|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |          X                                                               |      3     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cervix, Cyst                         |    X  X                                                                  |      9     |
      Cervix, Inflammation, Chronic Active |                3                                                         |      2  3.5|
      Cervix, Inflammation, Suppurative    |                   3                                                      |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 6|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 9| 8|                                            |            |
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 9| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0 G/KG                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    VEHICLEF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Endometrium, Cyst                    |                                                                          |      2     |
      Endometrium, Cyst, Multiple          |                                                                          |      1     |
      Endometrium, Hyperplasia             |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Mediastinal, Congestion              |                                                                          |      1  4.0|
      Mediastinal, Hemorrhage              | 2                                                                        |     13  2.1|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  3.0|
      Mediastinal, Inflammation,           |                                                                          |            |
          Granulomatous                    |                                                                          |      2  2.0|
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      |                                                                          |      9  1.8|
      Mediastinal, Sinus, Ectasia          |                                                                          |      1  2.0|
      Mesenteric, Hemorrhage               |       2                                                                  |      3  2.0|
      Mesenteric, Sinus, Ectasia           |       2                                                                  |      7  2.0|
      Pancreatic, Hemorrhage               |                2           3                                             |      3  2.3|
      Pancreatic, Pigmentation, Hemosiderin|                                                                          |      3  2.0|
      Pancreatic, Sinus, Ectasia           |                3                                                         |      2  2.5|
      Renal, Pigmentation, Hemosiderin     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  M  +  +  +  +  +  +                                             |  51        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             |                2           3                                             |      4  2.5|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Sinus, Ectasia                       |                            2                                             |      4  1.8|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ectopic Tissue                       |                            X                                             |      2     |
      Fibrosis, Focal                      |                            3                                             |      3  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      3  3.0|
      Inflammation, Granulomatous          |                                                                          |      2  4.0|
      Necrosis                             |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  M  +  +  +  +  M  +  +                                             |  42        |
      Congestion                           |                                                                          |      1  3.0|
      Ectopic Tissue                       |                                                                          |      1     |
      Hemorrhage                           |                         3                                                |      4  2.5|
      Epithelial Cell, Hyperplasia         |          2  2  2  2     2  2                                             |     38  1.9|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 6|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 9| 8|                                            |            |
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 9| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0 G/KG                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    VEHICLEF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Galactocele                          |                                                                          |      2     |
      Hyperplasia, Multifocal, Nodular     |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Duct, Ectasia                        |             2                                                            |      9  3.1|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Necrosis, Focal                      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |             3                                                            |      6  3.0|
      Hemorrhage                           |                            2                                             |      5  1.8|
      Infiltration Cellular, Histiocyte    | 1  1  1        1  1     1  1                                             |     49  1.0|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  1.0|
      Leukocytosis                         |                                                                          |      1  3.0|
      Necrosis, Multifocal                 |                                                                          |      1  4.0|
      Pigmentation                         | 1  1  1        1  1     1  1                                             |     49  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           | 2                                                                        |      3  2.3|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Foreign Body                         |                                                                          |      1  1.0|
      Inflammation                         |          2                                                               |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      5  1.6|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            |             3                                                            |      1  3.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 6|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 9| 8|                                            |            |
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 9| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0 G/KG                                 | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    VEHICLEF                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   4        |
      Cataract                             |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  4.0|
      Anterior Chamber, Inflammation,      |                                                                          |            |
          Suppurative                      |                                                                          |      1  3.0|
      Retina, Degeneration                 |                                                                          |      1  3.0|
      Sclera, Metaplasia, Osseous          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Concretion                           |                                                                          |      1  2.0|
      Cyst                                 |                   X                                                      |      1     |
      Hydronephrosis                       |                                                                          |      1  2.0|
      Nephropathy                          | 2  2  2  2  2  1  2  2  2  2                                             |     54  1.8|
      Pigmentation                         |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Serosa, Inflammation, Subacute       |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 2| 0| 3| 3| 2| 4| 5| 3| 3| 3| 3| 0| 3| 3| 2| 3| 0| 3| 3| 3| 3| 3|             
                                           | 8| 0| 0| 2| 3| 0| 0| 8| 8| 3| 0| 0| 0| 0| 4| 0| 0| 1| 0| 5| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    5 MG/KG                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    LOW FEMA                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                    2                     |             
      Basophilic Focus, Multifocal         |                   2        2     2  2     2     2  2  2        2  2      |             
      Eosinophilic Focus                   |                                                                4         |             
      Fatty Change, Diffuse                |                                                          3               |             
      Fatty Change, Multifocal             |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                     X        X                          X|             
      Inflammation, Acute, Multifocal      |                                                                          |             
      Inflammation, Chronic Active, Focal  |                                                                          |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |    1           2  1        1           1              1     1  1  1  1   |             
      Leukocytosis                         |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Bile Duct, Hyperplasia               |    2           2        2        2  1  2  2           1     2  2     2  1|             
      Centrilobular, Fatty Change          |                         2                                                |             
      Centrilobular, Necrosis, Coagulative |                                                                          |             
      Centrilobular, Necrosis              |                         2                                                |             
      Periportal, Fatty Change             |          2                                                               |             
                                            __________________________________________________________________________|             
   Mesentery                               | +     +                    +                          +  +               |             
      Fat, Necrosis, Focal                 |       4                    4                          4                  |             
      Fat, Necrosis, Multifocal            |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |             2                 2  3     3        2                        |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 | 2  1  3  2  1  3  1     1  1  2  1  1  2  1  2  1  1  2  2  1  1  2  1  2|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Lamina Propria, Fibrosis, Focal      |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 2| 0| 3| 3| 2| 4| 5| 3| 3| 3| 3| 0| 3| 3| 2| 3| 0| 3| 3| 3| 3| 3|             
                                           | 8| 0| 0| 2| 3| 0| 0| 8| 8| 3| 0| 0| 0| 0| 4| 0| 0| 1| 0| 5| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    5 MG/KG                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    LOW FEMA                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1                 2        2     2              1           2        2|             
      Aortic Valve, Inflammation, Chronic  |                                                                          |             
          Active                           |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Angiectasis                          |                   2        3                                             |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia, Multifocal              |                                                                          |             
      Necrosis, Focal                      |                                                          3               |             
      Vacuolization Cytoplasmic, Diffuse   |                                                          3               |             
      Vacuolization Cytoplasmic, Focal     |                                                       2                  |             
      Vacuolization Cytoplasmic, Multifocal|                   2                                                      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                       2                  |             
      Hyperplasia, Multifocal              |                         2  2                                             |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2                                                              2      |             
      Cyst                                 |    X        X           X     X                       X  X     X  X  X   |             
      Pigmentation, Hemosiderin            |                                                       2        2         |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
      Pars Distalis, Hyperplasia           |       3                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                   3                                                      |             
      Ultimobranchial Cyst                 |          X                                                               |             
      C-Cell, Hyperplasia                  |                2                             2                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                        2                                 |             
      Duct, Ectasia                        |                               2        2                                 |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    X  X                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 2| 0| 3| 3| 2| 4| 5| 3| 3| 3| 3| 0| 3| 3| 2| 3| 0| 3| 3| 3| 3| 3|             
                                           | 8| 0| 0| 2| 3| 0| 0| 8| 8| 3| 0| 0| 0| 0| 4| 0| 0| 1| 0| 5| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    5 MG/KG                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    LOW FEMA                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Cervix, Cyst                         |    X           X              X                 X                        |             
      Cervix, Hypertrophy                  |                                                                          |             
      Cervix, Inflammation, Suppurative    |                                                                          |             
      Endometrium, Cyst                    |                                                                   X      |             
      Endometrium, Hyperplasia, Cystic     |    3                                                                     |             
      Endometrium, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Hemorrhage                           |                                                                          |             
      Mediastinal, Hemorrhage              |                         2              2                                2|             
      Mediastinal, Hyperplasia, Reticulum  |                                                                          |             
          Cell                             |                                                                          |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                                        2  2  2                          2|             
      Mediastinal, Sinus, Ectasia          |                                                                          |             
      Mesenteric, Hemorrhage               |                                                                          |             
      Mesenteric, Pigmentation, Hemosiderin|                                                                      2   |             
      Mesenteric, Sinus, Ectasia           | 2        2     2  2        2        2                       2  2         |             
      Pancreatic, Hemorrhage               |    2                                         2                           |             
      Pancreatic, Pigmentation, Hemosiderin|                         2                 2                              |             
      Pancreatic, Sinus, Ectasia           |                         2                                                |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                                                3         |             
      Renal, Pigmentation, Hemosiderin     |                                                                3         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  M|             
      Hyperplasia, Plasma Cell             |          2              2                                                |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                                                          |             
      Fibrosis, Focal                      |                                  3                                       |             
      Hematopoietic Cell Proliferation     |                            4                                             |             
      Red Pulp, Atrophy                    |                                                    3                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  M  +  +  M  M  +  M  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                      3                                                   |             
      Cyst                                 |                                                       X                  |             
      Ectopic Tissue                       |                                                          X               |             
      Hemorrhage                           |                                                                          |             
      Epithelial Cell, Hyperplasia         |    2  2  2  1  2  2        2  2        2     2  2     2  2  2  2  2  2  2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 2| 0| 3| 3| 2| 4| 5| 3| 3| 3| 3| 0| 3| 3| 2| 3| 0| 3| 3| 3| 3| 3|             
                                           | 8| 0| 0| 2| 3| 0| 0| 8| 8| 3| 0| 0| 0| 0| 4| 0| 0| 1| 0| 5| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    5 MG/KG                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    LOW FEMA                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  M  +  +  +  +  +|             
      Duct, Ectasia                        |                                     3     3  3                 3         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                                 +                        |             
      Femur, Osteopetrosis                 |                                                 3                        |             
      Vertebra, Osteopetrosis              |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebrum, Gliosis                    |                      2                                                   |             
      Cerebrum, Necrosis                   |                         2                                                |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |             2        3                             2                     |             
      Fungus                               |                                                                          |             
      Hemorrhage                           |       1                                2                                 |             
      Infiltration Cellular, Histiocyte    |    1  1  1     1  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Pigmentation, Diffuse, Hemosiderin   |                                  3                                       |             
      Pigmentation                         |    1  1  1     1  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                               2                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                                                                          |             
      Inflammation, Suppurative            |                                  2                                       |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Middle Ear, Inflammation, Suppurative|                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +              +                                             |             
      Cataract                             |                            3                                             |             
      Necrosis                             |                            4                                             |             
      Retina, Degeneration                 |                                                                          |             
      Sclera, Metaplasia, Osseous          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 2| 0| 3| 3| 2| 4| 5| 3| 3| 3| 3| 0| 3| 3| 2| 3| 0| 3| 3| 3| 3| 3|             
                                           | 8| 0| 0| 2| 3| 0| 0| 8| 8| 3| 0| 0| 0| 0| 4| 0| 0| 1| 0| 5| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    5 MG/KG                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    LOW FEMA                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          |    2  1  2     1  2  2  2     1  2  2  1  1  1  1  2     1  1  3  1  1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Serosa, Inflammation, Chronic        |                                                                          |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 4| 3| 3| 3| 7| 2| 3| 3| 3| 9| 8|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 9| 0| 0| 0| 0| 0| 8| 0| 0| 0| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    5 MG/KG                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    LOW FEMA                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                       4                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus, Multifocal         |    2  2  2  2  2     2     2     2  2                          2  2      |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change, Diffuse                |                                                          2               |             
      Fatty Change, Multifocal             |                                                       2                  |             
      Hepatodiaphragmatic Nodule           | X        X              X  X                                             |             
      Inflammation, Acute, Multifocal      |             1                                                            |             
      Inflammation, Chronic Active, Focal  |                                                                         2|             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                1     1           2           1                           |             
      Leukocytosis                         |                                              1                           |             
      Mixed Cell Focus                     |                                                                   2      |             
      Bile Duct, Hyperplasia               |          2  2  2  2  1  2  2     2  2  2  2  2  2  2     2  3  2  2  2  1|             
      Centrilobular, Fatty Change          |                                           2                              |             
      Centrilobular, Necrosis, Coagulative |                                                                          |             
      Centrilobular, Necrosis              |                                                                          |             
      Periportal, Fatty Change             |                                                    2                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                   +           +         |             
      Fat, Necrosis, Focal                 |                4                                   4                     |             
      Fat, Necrosis, Multifocal            |                                                                4         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |    2  1           1           2                    1                 1   |             
      Acinus, Hyperplasia, Focal           |                                     2                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                       2                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 | 2  2  2  2  1  2  2  1  2     2  2  2  1     2  2  2  1  2  2  2  2  1  2|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                             2            |             
      Lamina Propria, Fibrosis, Focal      |                                                                         2|             
                                            __________________________________________________________________________|             
   Tongue                                  |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 4| 3| 3| 3| 7| 2| 3| 3| 3| 9| 8|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 9| 0| 0| 0| 0| 0| 8| 0| 0| 0| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    5 MG/KG                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    LOW FEMA                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2     2  1  2  1                 2                 2              2  2   |             
      Aortic Valve, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Angiectasis                          |                                                                          |             
      Hyperplasia, Focal                   |    2     2                    2                                          |             
      Hyperplasia, Multifocal              |                      2                                                   |             
      Necrosis, Focal                      |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |                                        2                                 |             
      Vacuolization Cytoplasmic, Focal     |    2  2                                   2        2                     |             
      Vacuolization Cytoplasmic, Multifocal|                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  M|             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia, Multifocal              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                              2                           |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  M  +  M  +  M  +  M  +  +  +  +  +  +  +  M  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2              3        3                             2            |             
      Cyst                                 |                X  X        X              X                              |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                            2              2                              |             
      Pars Distalis, Hyperplasia           |       3                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                          |             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |          2           2     2           2           2  2                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                          3               |             
      Duct, Ectasia                        |                                     3        3     2                     |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 4| 3| 3| 3| 7| 2| 3| 3| 3| 9| 8|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 9| 0| 0| 0| 0| 0| 8| 0| 0| 0| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    5 MG/KG                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    LOW FEMA                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |    3           3                                                         |             
      Inflammation, Chronic Active         |                               3                                          |             
      Cervix, Cyst                         |    X  X        X                    X                          X     X   |             
      Cervix, Hypertrophy                  |                                              3                           |             
      Cervix, Inflammation, Suppurative    |       3                                                  3               |             
      Endometrium, Cyst                    |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                               4                                   2      |             
      Endometrium, Hyperplasia             |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |    2                                                                     |             
      Mediastinal, Hemorrhage              |                3                 2                 2  2                  |             
      Mediastinal, Hyperplasia, Reticulum  |                                                                          |             
          Cell                             | 2                                                                        |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |    2        2                    2                                       |             
      Mediastinal, Sinus, Ectasia          |                                        2                                 |             
      Mesenteric, Hemorrhage               |                                                       2                  |             
      Mesenteric, Pigmentation, Hemosiderin|                                                                          |             
      Mesenteric, Sinus, Ectasia           | 2        2                                         2           2         |             
      Pancreatic, Hemorrhage               |                                                                          |             
      Pancreatic, Pigmentation, Hemosiderin|                   3                                                     2|             
      Pancreatic, Sinus, Ectasia           |                                                                          |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                                                          |             
      Renal, Pigmentation, Hemosiderin     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             |                   3     3                       2                       3|             
      Sinus, Ectasia                       |                   2                                                      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                               X                                X         |             
      Fibrosis, Focal                      |                   3     3              2                                 |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Red Pulp, Atrophy                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Ectopic Tissue                       |                                                                          |             
      Hemorrhage                           |                                     2                                    |             
      Epithelial Cell, Hyperplasia         | 2  2  2  2  2  2  2     2     2  2  2  2  2  2  2  2     2  2  2  2  2   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 4| 3| 3| 3| 7| 2| 3| 3| 3| 9| 8|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 9| 0| 0| 0| 0| 0| 8| 0| 0| 0| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    5 MG/KG                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    LOW FEMA                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Ectasia                        |          3                             3                                 |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                                       +                  |             
      Femur, Osteopetrosis                 |                                                                          |             
      Vertebra, Osteopetrosis              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebrum, Gliosis                    |                                                                          |             
      Cerebrum, Necrosis                   |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Fungus                               |                                           X                              |             
      Hemorrhage                           |                      1                       1                           |             
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1     1  1     1  1  1  1  1     1  1  1  1        1  1  1   |             
      Inflammation, Focal, Granulomatous   |                                           3                              |             
      Pigmentation, Diffuse, Hemosiderin   |                                                                          |             
      Pigmentation                         | 1  1  1  1  1     1  1     1  1  1  1  1     1  1  1  1        1  1  1   |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                         2|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |                            2                                             |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                                                                          |             
      Inflammation, Suppurative            |                               2                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |       +                                                                  |             
      Middle Ear, Inflammation, Suppurative|                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +  +                                +                              |             
      Cataract                             |       3                                                                  |             
      Necrosis                             |          4                                                               |             
      Retina, Degeneration                 |       3                                                                  |             
      Sclera, Metaplasia, Osseous          |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 4| 3| 3| 3| 7| 2| 3| 3| 3| 9| 8|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 9| 0| 0| 0| 0| 0| 8| 0| 0| 0| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    5 MG/KG                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    LOW FEMA                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                                                                  |             
      Infiltration Cellular, Lymphocyte    |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 2  3  2  2  2  1  1  1  2  2     1  2     1  2  1  2  2     1  2  1  2  3|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |       1                    1           1                                 |             
      Serosa, Inflammation, Chronic        |                                                       3                  |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 4| 3| 3| 3| 3| 0|                                            |            |
                                           | 0| 0| 0| 0| 9| 0| 0| 0| 0| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    5 MG/KG                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    LOW FEMA                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | M  +  +  +  +  +  +  +  +  +                                             |  59        |
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus, Multifocal         |    2     2     2     2  2                                                |     26  2.0|
      Eosinophilic Focus                   |                                                                          |      1  4.0|
      Fatty Change, Diffuse                |                                                                          |      2  2.5|
      Fatty Change, Multifocal             |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           | X                                                                        |      8     |
      Inflammation, Acute, Multifocal      |                                                                          |      1  1.0|
      Inflammation, Chronic Active, Focal  |                                                                          |      1  2.0|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |          1           1                                                   |     16  1.1|
      Leukocytosis                         |                                                                          |      1  1.0|
      Mixed Cell Focus                     |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               | 2  1     2  2  2                                                         |     37  1.9|
      Centrilobular, Fatty Change          |                                                                          |      2  2.0|
      Centrilobular, Necrosis, Coagulative |       2                    2                                             |      2  2.0|
      Centrilobular, Necrosis              |                                                                          |      1  2.0|
      Periportal, Fatty Change             |             3                                                            |      3  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +     +                                                   |  10        |
      Fat, Necrosis, Focal                 |                4     4                                                   |      7  4.0|
      Fat, Necrosis, Multifocal            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acinus, Atrophy                      |    1                 2                                                   |     13  1.8|
      Acinus, Hyperplasia, Focal           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Ulcer                                |             3                                                            |      2  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 4| 3| 3| 3| 3| 0|                                            |            |
                                           | 0| 0| 0| 0| 9| 0| 0| 0| 0| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    5 MG/KG                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    LOW FEMA                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Degeneration, Cystic                 | 2  1  2  1     2  2  1  2  1                                             |     56  1.6|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  2.0|
      Lamina Propria, Fibrosis, Focal      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       |    1           2     1  2                                                |     21  1.7|
      Aortic Valve, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Accessory Adrenal Cortical Nodule    |                            X                                             |      1     |
      Angiectasis                          |                                                                          |      2  2.5|
      Hyperplasia, Focal                   |                                                                          |      3  2.0|
      Hyperplasia, Multifocal              |                                                                          |      1  2.0|
      Necrosis, Focal                      |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |      2  2.5|
      Vacuolization Cytoplasmic, Focal     |                            2                                             |      6  2.0|
      Vacuolization Cytoplasmic, Multifocal|                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  54        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Hyperplasia, Multifocal              |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  M  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |          2                                                               |      7  2.3|
      Cyst                                 |                      X  X                                                |     15     |
      Pigmentation, Hemosiderin            |                                                                          |      2  2.0|
      Pars Distalis, Hyperplasia, Focal    |    2                                                                     |      3  2.0|
      Pars Distalis, Hyperplasia           |       3        3                                                         |      4  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Subacute               |                                                                          |      1  3.0|
      Ultimobranchial Cyst                 |                      X                                                   |      2     |
      C-Cell, Hyperplasia                  |       2        2                                                         |     10  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 4| 3| 3| 3| 3| 0|                                            |            |
                                           | 0| 0| 0| 0| 9| 0| 0| 0| 0| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    5 MG/KG                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    LOW FEMA                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
      Duct, Ectasia                        |          3  2                                                            |      7  2.4|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hydrometra                           |                         2                                                |      3  2.7|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Cervix, Cyst                         |       X  X                                                               |     12     |
      Cervix, Hypertrophy                  |                                                                          |      1  3.0|
      Cervix, Inflammation, Suppurative    |                                                                          |      2  3.0|
      Endometrium, Cyst                    |                                                                          |      1     |
      Endometrium, Hyperplasia, Cystic     |          3     3           2                                             |      6  2.8|
      Endometrium, Hyperplasia             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Mediastinal, Hemorrhage              |                                                                          |      7  2.1|
      Mediastinal, Hyperplasia, Reticulum  |                                                                          |            |
          Cell                             |                                                                          |      1  2.0|
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      |                                                                          |      7  2.0|
      Mediastinal, Sinus, Ectasia          |                                                                          |      1  2.0|
      Mesenteric, Hemorrhage               |       2           2                                                      |      3  2.0|
      Mesenteric, Pigmentation, Hemosiderin|                                                                          |      1  2.0|
      Mesenteric, Sinus, Ectasia           |                2  3                                                      |     14  2.1|
      Pancreatic, Hemorrhage               |                                                                          |      2  2.0|
      Pancreatic, Pigmentation, Hemosiderin|                                                                          |      4  2.3|
      Pancreatic, Sinus, Ectasia           |                                                                          |      1  2.0|
      Renal, Infiltration Cellular,        |                                                                          |            |
          Histiocyte                       |                                                                          |      1  3.0|
      Renal, Pigmentation, Hemosiderin     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +                                             |  52        |
      Hyperplasia, Plasma Cell             |                                                                          |      6  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 4| 3| 3| 3| 3| 0|                                            |            |
                                           | 0| 0| 0| 0| 9| 0| 0| 0| 0| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    5 MG/KG                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    LOW FEMA                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Sinus, Ectasia                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ectopic Tissue                       |                                                                          |      2     |
      Fibrosis, Focal                      |                                                                          |      4  2.8|
      Hematopoietic Cell Proliferation     |       3                    2                                             |      3  3.0|
      Red Pulp, Atrophy                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  +  +  +  +                                             |  51        |
      Congestion                           |                                                                          |      1  3.0|
      Cyst                                 |                                                                          |      1     |
      Ectopic Tissue                       |                                                                          |      1     |
      Hemorrhage                           |                                                                          |      1  2.0|
      Epithelial Cell, Hyperplasia         | 2  2  2  2  2     2  2  2  2                                             |     48  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  M                                             |  55        |
      Duct, Ectasia                        |             3                                                            |      7  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |   2        |
      Femur, Osteopetrosis                 |                                                                          |      1  3.0|
      Vertebra, Osteopetrosis              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cerebrum, Gliosis                    |                                                                          |      1  2.0|
      Cerebrum, Necrosis                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      3  2.3|
      Fungus                               |                                                                          |      1     |
      Hemorrhage                           | 1                                                                        |      5  1.2|
      Infiltration Cellular, Histiocyte    | 1  1  1  1  1  1  1  1  1  1                                             |     51  1.0|
      Inflammation, Focal, Granulomatous   |                                                                          |      1  3.0|
      Pigmentation, Diffuse, Hemosiderin   |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 5|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 4| 3| 3| 3| 3| 0|                                            |            |
                                           | 0| 0| 0| 0| 9| 0| 0| 0| 0| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    5 MG/KG                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    LOW FEMA                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Pigmentation                         | 1  1  1  1  1  1  1  1  1  1                                             |     51  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                2                                                         |      3  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fungus                               |       X                                                                  |      1     |
      Inflammation, Suppurative            |    2  2                                                                  |      4  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |       +     +                                                            |   3        |
      Middle Ear, Inflammation, Suppurative|       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |       +     +                                                            |   7        |
      Cataract                             |       3                                                                  |      3  3.0|
      Necrosis                             |                                                                          |      2  4.0|
      Retina, Degeneration                 |       3                                                                  |      2  3.0|
      Sclera, Metaplasia, Osseous          |             1                                                            |      2  1.5|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Nephropathy                          | 1  1  1     3  1  2  2     1                                             |     51  1.6|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Infiltration Cellular, Lymphocyte    |          2                                                               |      4  1.3|
      Serosa, Inflammation, Chronic        |                                                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia,|                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 6| 6| 6| 6| 6| 7| 7| 6| 5| 4| 7| 6| 6| 1| 1| 7| 7| 1| 1| 1|             
                             DAY ON TEST   | 2| 2| 2| 5| 4| 4| 4| 4| 4| 4| 2| 2| 9| 1| 9| 2| 6| 4| 5| 0| 2| 2| 4| 0| 0|             
                                           | 9| 9| 9| 9| 9| 7| 6| 6| 6| 2| 9| 9| 1| 6| 5| 9| 0| 9| 2| 3| 9| 9| 1| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10MG/KG                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    HIGH FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                        2                       2         |             
      Basophilic Focus, Focal              |                                                                          |             
      Basophilic Focus                     |                   2                       1                              |             
      Basophilic Focus, Multifocal         | 2  2                                2                                    |             
      Congestion                           |                                                                          |             
      Fatty Change, Diffuse                |                                                                          |             
      Fatty Change, Multifocal             |                                                                          |             
      Hepatodiaphragmatic Nodule           |    X              X     X     X     X                 X     X            |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       | 1  1        1  1     1  1        1  1     1     1           2  2         |             
      Bile Duct, Hyperplasia               |    2  2  1  2           1  2  3              2  2  2                     |             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                +                              |             
      Fat, Necrosis, Focal                 |          4                                4                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Acinus, Atrophy                      |    1                       2  3                 1           2            |             
      Acinus, Cytoplasmic Alteration, Focal|                                  1                                       |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Hyperplasia, Focal                   |          1                                      2                        |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Degeneration, Cystic                 | 2  1  2  1  1  1  1  2  2     1  3  2  2     2     1        1  2         |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  1  2                 2  2  2              2                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 6| 6| 6| 6| 6| 7| 7| 6| 5| 4| 7| 6| 6| 1| 1| 7| 7| 1| 1| 1|             
                             DAY ON TEST   | 2| 2| 2| 5| 4| 4| 4| 4| 4| 4| 2| 2| 9| 1| 9| 2| 6| 4| 5| 0| 2| 2| 4| 0| 0|             
                                           | 9| 9| 9| 9| 9| 7| 6| 6| 6| 2| 9| 9| 1| 6| 5| 9| 0| 9| 2| 3| 9| 9| 1| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10MG/KG                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    HIGH FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Artery, Degeneration                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia, Multifocal              |                                                                          |             
      Necrosis, Multifocal                 |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |       2              2                                                   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Bilateral, Hyperplasia, Focal        |                                                                          |             
      Bilateral, Hyperplasia, Multifocal   |                                  2                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  M  M  +  +  +  +  +  +  +  +  M  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 | X     X           X     X           X  X     X  X           X  X         |             
      Hemorrhage                           |                            2                                             |             
      Pars Distalis, Hyperplasia, Focal    |                                              1                 2         |             
      Pars Distalis, Hyperplasia           |                   2                                         3            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                        X                                 |             
      C-Cell, Hyperplasia                  |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  M  M  M|             
      Duct, Ectasia                        |    3                                               2                     |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |    X                                   X     X                           |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cervix, Cyst                         |    X        X                       X                                    |             
      Cervix, Inflammation, Suppurative    |                                        2                                 |             
      Endometrium, Cyst                    |       3                    X                                             |             
      Endometrium, Hyperplasia, Cystic     |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 6| 6| 6| 6| 6| 7| 7| 6| 5| 4| 7| 6| 6| 1| 1| 7| 7| 1| 1| 1|             
                             DAY ON TEST   | 2| 2| 2| 5| 4| 4| 4| 4| 4| 4| 2| 2| 9| 1| 9| 2| 6| 4| 5| 0| 2| 2| 4| 0| 0|             
                                           | 9| 9| 9| 9| 9| 7| 6| 6| 6| 2| 9| 9| 1| 6| 5| 9| 0| 9| 2| 3| 9| 9| 1| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10MG/KG                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    HIGH FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation, Hemosiderin            |                                     2                                    |             
      Mediastinal, Hemorrhage              |             2     3     2                                                |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                                  2                                       |             
      Mesenteric, Hemorrhage               |             3                                                            |             
      Mesenteric, Sinus, Ectasia           |                                        2  2                              |             
      Pancreatic, Pigmentation, Hemosiderin|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M|             
      Hemorrhage                           |          2                                                               |             
      Hyperplasia, Plasma Cell             |                                  3                          3            |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                                                          |             
      Fibrosis, Focal                      |       4                                                                  |             
      Hemorrhage, Focal                    |                                                                          |             
      Inflammation, Necrotizing            |                                                       4                  |             
      Red Pulp, Atrophy                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  M  +  +  +  M  +  +  +  +  +  +  +  M  M  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                            X     X                                       |             
      Depletion Lymphoid                   |                                                                          |             
      Hemorrhage                           |                                                                         2|             
      Epithelial Cell, Hyperplasia         | 2  2  2  2  2  1     2     2     2     2     2     2  2                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Duct, Ectasia                        |    2                                                                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Hemorrhage                           |                                                                          |             
      Cerebrum, Necrosis                   |    2  2  2  1  4  2  2  4  4        3  3  3     3     2     2        4  4|             
      Hippocampus, Necrosis                |                                                 3                        |             
      Thalamus, Necrosis                   |          3  1  2  2  2     1        2  2        4     4  2               |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 6| 6| 6| 6| 6| 7| 7| 6| 5| 4| 7| 6| 6| 1| 1| 7| 7| 1| 1| 1|             
                             DAY ON TEST   | 2| 2| 2| 5| 4| 4| 4| 4| 4| 4| 2| 2| 9| 1| 9| 2| 6| 4| 5| 0| 2| 2| 4| 0| 0|             
                                           | 9| 9| 9| 9| 9| 7| 6| 6| 6| 2| 9| 9| 1| 6| 5| 9| 0| 9| 2| 3| 9| 9| 1| 8| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    10MG/KG                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    HIGH FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                3  3  3                          3  3  4  3           3  3|             
      Hemorrhage                           |                         1                                                |             
      Infiltration Cellular, Histiocyte    | 1  1     1  1  1  1  1  1  1  1  1  1  1  1  1  1           1  1         |             
      Pigmentation                         | 1  1     1  1  1  1  1  1  1  1  1  1  1  1  1  1           1  1         |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                   2                                                      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |          2                                                               |             
      Fungus                               |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |          2                                                               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                        +  +                              |             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +                                 |             
      Cataract                             |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                          +               |             
      Infiltration Cellular, Lymphocyte    |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                        X     X                           |             
      Nephropathy                          | 1  2  1  1  2        2  1        3           1     2        1  1         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 4| 1| 1| 7| 6| 6| 5| 2| 7| 7| 7| 6| 6| 7| 7| 7| 5| 1| 7| 6| 6| 6| 3|             
                             DAY ON TEST   | 6| 2| 8| 0| 0| 2| 8| 5| 0| 0| 2| 2| 0| 6| 1| 2| 2| 2| 6| 0| 2| 5| 5| 5| 9|             
                                           | 5| 9| 8| 8| 6| 9| 8| 4| 2| 1| 9| 9| 5| 7| 0| 9| 9| 9| 9| 9| 9| 0| 4| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    10MG/KG                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    HIGH FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                           3                              |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2                                                                     |             
      Basophilic Focus, Focal              |                         2                                                |             
      Basophilic Focus                     |                                                                          |             
      Basophilic Focus, Multifocal         |    2              2           2  2           2  2  2  2     2           2|             
      Congestion                           |                                                                          |             
      Fatty Change, Diffuse                |                                                                          |             
      Fatty Change, Multifocal             |                      1                    1                              |             
      Hepatodiaphragmatic Nodule           |                                                 X     X              X   |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |       1           1  1  1     2  1           1  1  1                 1  1|             
      Bile Duct, Hyperplasia               |    2  1           1  1           2     2     2  2  2        2  2     1   |             
      Centrilobular, Necrosis              |                                                                   2      |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                +        +                     |             
      Fat, Necrosis, Focal                 |          4                                4        4                     |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                      2        1     1                                   1|             
      Acinus, Cytoplasmic Alteration, Focal|                1                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Chronic                |                                           1     2                        |             
      Ulcer                                |          4                                                               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |    2        1        1     1  1  2  1  1        2  2        2     1  1   |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Cardiomyopathy                       |    1           2              2  2           2     2        2     2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 4| 1| 1| 7| 6| 6| 5| 2| 7| 7| 7| 6| 6| 7| 7| 7| 5| 1| 7| 6| 6| 6| 3|             
                             DAY ON TEST   | 6| 2| 8| 0| 0| 2| 8| 5| 0| 0| 2| 2| 0| 6| 1| 2| 2| 2| 6| 0| 2| 5| 5| 5| 9|             
                                           | 5| 9| 8| 8| 6| 9| 8| 4| 2| 1| 9| 9| 5| 7| 0| 9| 9| 9| 9| 9| 9| 0| 4| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    10MG/KG                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    HIGH FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Artery, Degeneration                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   2                                         2            |             
      Hyperplasia, Focal                   |                2                                            2            |             
      Hyperplasia, Multifocal              |                                                                          |             
      Necrosis, Multifocal                 |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                               2     2                 2                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Bilateral, Hyperplasia, Focal        |                                                             2            |             
      Bilateral, Hyperplasia, Multifocal   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      2                    2        2                     |             
      Cyst                                 |                   X                 X        X     X        X            |             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |    2                                      2                          2   |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                  X                                       |             
      C-Cell, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |    +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Duct, Ectasia                        |                                                             3            |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                          4               |             
      Cyst                                 |                                           X                              |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cervix, Cyst                         |                                                    X                     |             
      Cervix, Inflammation, Suppurative    |                                                                          |             
      Endometrium, Cyst                    |                                  X                                       |             
      Endometrium, Hyperplasia, Cystic     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             3                                            3               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 4| 1| 1| 7| 6| 6| 5| 2| 7| 7| 7| 6| 6| 7| 7| 7| 5| 1| 7| 6| 6| 6| 3|             
                             DAY ON TEST   | 6| 2| 8| 0| 0| 2| 8| 5| 0| 0| 2| 2| 0| 6| 1| 2| 2| 2| 6| 0| 2| 5| 5| 5| 9|             
                                           | 5| 9| 8| 8| 6| 9| 8| 4| 2| 1| 9| 9| 5| 7| 0| 9| 9| 9| 9| 9| 9| 0| 4| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    10MG/KG                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    HIGH FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation, Hemosiderin            |                                                                          |             
      Mediastinal, Hemorrhage              |                               2  2  3        2                           |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                2              2  2           2                           |             
      Mesenteric, Hemorrhage               |                                                                   3      |             
      Mesenteric, Sinus, Ectasia           |    2                                2                                    |             
      Pancreatic, Pigmentation, Hemosiderin|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  M  M  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  M  +  +|             
      Hemorrhage                           |                         2                                                |             
      Hyperplasia, Plasma Cell             |                                  2  2                 2                  |             
      Pigmentation, Hemosiderin            |                                     2                                    |             
      Sinus, Ectasia                       |                                                       2                  |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                           X              X               |             
      Fibrosis, Focal                      |                                                                          |             
      Hemorrhage, Focal                    |                                                                          |             
      Inflammation, Necrotizing            |                                                                          |             
      Red Pulp, Atrophy                    |                                                                      3   |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  +  +  +  +  I  +  +  +  +  M  +  +  M  +  +  M  +  +  +  +  M|             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Depletion Lymphoid                   |             2                                                            |             
      Hemorrhage                           |                            2                                             |             
      Epithelial Cell, Hyperplasia         |    2     1     2  1  2     1     2  2     2  2     1  2     2     1  2   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                           3                              |             
      Cerebrum, Necrosis                   |          4  2        3     4  2     3     3           2  3     2     3   |             
      Hippocampus, Necrosis                |          4                                                     2         |             
      Thalamus, Necrosis                   |          4  4        3     3        3  2  4                          3   |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 4| 1| 1| 7| 6| 6| 5| 2| 7| 7| 7| 6| 6| 7| 7| 7| 5| 1| 7| 6| 6| 6| 3|             
                             DAY ON TEST   | 6| 2| 8| 0| 0| 2| 8| 5| 0| 0| 2| 2| 0| 6| 1| 2| 2| 2| 6| 0| 2| 5| 5| 5| 9|             
                                           | 5| 9| 8| 8| 6| 9| 8| 4| 2| 1| 9| 9| 5| 7| 0| 9| 9| 9| 9| 9| 9| 0| 4| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    10MG/KG                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    HIGH FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |       3  3        3  3  3  3                             4           2  3|             
      Hemorrhage                           |    1           1                    1     1                              |             
      Infiltration Cellular, Histiocyte    |    1  1        1  1  1  1     1  1  1  1  1  1  1  1        1     1  1   |             
      Pigmentation                         |    1  1        1  1  1  1     1  1  1  1  1  1  1  1        1     1  1   |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                    1              1      |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |       2                                                                  |             
      Fungus                               |                                        X  X                              |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |       2                                3  3     2                        |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                             +            |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                             +            |             
      Cataract                             |                                                             3            |             
      Retina, Degeneration                 |                                                             3            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Nephropathy                          |                1     2           1              1           2            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 2| 7| 7| 5| 4| 4|                                            |            |
                             DAY ON TEST   | 2| 2| 2| 1| 0| 2| 2| 0| 6| 4|                                            |            |
                                           | 9| 9| 9| 2| 6| 9| 9| 2| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    10MG/KG                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|                                            |      L     |
    HIGH FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  A  +  +  +  +  +  +                                             |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +                                             |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  +                                             |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Angiectasis                          | 2                                                                        |      4  2.0|
      Basophilic Focus, Focal              |                                                                          |      1  2.0|
      Basophilic Focus                     |       2  2              2                                                |      5  1.8|
      Basophilic Focus, Multifocal         | 2  2           2  2  2                                                   |     18  2.0|
      Congestion                           |                         3                                                |      1  3.0|
      Fatty Change, Diffuse                |                            2                                             |      1  2.0|
      Fatty Change, Multifocal             |                                                                          |      2  1.0|
      Hepatodiaphragmatic Nodule           |          X                                                               |     11     |
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       | 1           1  1  1  1                                                   |     28  1.1|
      Bile Duct, Hyperplasia               |          3     1     2  2  2                                             |     27  1.8|
      Centrilobular, Necrosis              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +  +                                                                  |   7        |
      Fat, Necrosis, Focal                 |    4  3                                                                  |      7  3.9|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Acinus, Atrophy                      |          1                 1                                             |     11  1.5|
      Acinus, Cytoplasmic Alteration, Focal|                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +     +  +  +                                             |  57        |
      Hyperplasia, Focal                   |                                                                          |      2  1.5|
      Inflammation, Chronic                |                                                                          |      2  1.5|
      Ulcer                                |             3                                                            |      2  3.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Degeneration, Cystic                 | 2  1  2  2     2  2  2                                                   |     37  1.6|
      Ulcer                                |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                   +                                                      |   1        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 2| 7| 7| 5| 4| 4|                                            |            |
                             DAY ON TEST   | 2| 2| 2| 1| 0| 2| 2| 0| 6| 4|                                            |            |
                                           | 9| 9| 9| 2| 6| 9| 9| 2| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    10MG/KG                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|                                            |      L     |
    HIGH FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
           Chronic Active                  |                   3                                                      |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Cardiomyopathy                       |    2  1              1  1                                                |     19  1.7|
      Artery, Degeneration                 | 1                                                                        |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +     +  +  +  +  +  +  +  +                                             |  58        |
      Angiectasis                          |                                                                          |      2  2.0|
      Hyperplasia, Focal                   |                                                                          |      2  2.0|
      Hyperplasia, Multifocal              |                2                                                         |      1  2.0|
      Necrosis, Multifocal                 |                      3                                                   |      1  3.0|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      5  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  M  +  +  +  +  +                                             |  56        |
      Hyperplasia, Focal                   |    2                                                                     |      1  2.0|
      Bilateral, Hyperplasia, Focal        |                                                                          |      1  2.0|
      Bilateral, Hyperplasia, Multifocal   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  M  +  +  +  M                                             |  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Angiectasis                          |                         2  2                                             |      5  2.0|
      Cyst                                 |                                                                          |     15     |
      Hemorrhage                           |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia, Focal    |    1                                                                     |      6  1.7|
      Pars Distalis, Hyperplasia           | 3                                                                        |      3  2.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  M                                             |  56        |
      Ultimobranchial Cyst                 |                                                                          |      2     |
      C-Cell, Hyperplasia                  |                2                                                         |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  M  +  +  M  +  +  +  +  +                                             |  49        |
      Duct, Ectasia                        |                3                                                         |      4  2.8|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Congestion                           |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 2| 7| 7| 5| 4| 4|                                            |            |
                             DAY ON TEST   | 2| 2| 2| 1| 0| 2| 2| 0| 6| 4|                                            |            |
                                           | 9| 9| 9| 2| 6| 9| 9| 2| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    10MG/KG                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|                                            |      L     |
    HIGH FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                                                                          |      4     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cervix, Cyst                         |    X                                                                     |      5     |
      Cervix, Inflammation, Suppurative    |                                                                          |      1  2.0|
      Endometrium, Cyst                    |                                                                          |      3  3.0|
      Endometrium, Hyperplasia, Cystic     |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Atrophy                              |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Mediastinal, Hemorrhage              |             2     2                                                      |      9  2.2|
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      |                   2                                                      |      6  2.0|
      Mesenteric, Hemorrhage               |                                                                          |      2  3.0|
      Mesenteric, Sinus, Ectasia           |                   2  2                                                   |      6  2.0|
      Pancreatic, Pigmentation, Hemosiderin|                2     2                                                   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +     +  +  +  M  +  +                                             |  50        |
      Hemorrhage                           |                                                                          |      2  2.0|
      Hyperplasia, Plasma Cell             |                   2                                                      |      6  2.3|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Sinus, Ectasia                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Ectopic Tissue                       |                                                                          |      2     |
      Fibrosis, Focal                      |                                                                          |      1  4.0|
      Hemorrhage, Focal                    |    2                                                                     |      1  2.0|
      Inflammation, Necrotizing            |                                                                          |      1  4.0|
      Red Pulp, Atrophy                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Congestion                           |          2                                                               |      1  2.0|
      Cyst                                 |                                                                          |      2     |
      Depletion Lymphoid                   |                                                                          |      1  2.0|
      Hemorrhage                           |                         2                                                |      3  2.0|
      Epithelial Cell, Hyperplasia         | 2  2  2  1  1     2  2                                                   |     35  1.8|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Duct, Ectasia                        |                      2                                                   |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 2| 7| 7| 5| 4| 4|                                            |            |
                             DAY ON TEST   | 2| 2| 2| 1| 0| 2| 2| 0| 6| 4|                                            |            |
                                           | 9| 9| 9| 2| 6| 9| 9| 2| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    10MG/KG                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|                                            |      L     |
    HIGH FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Cerebrum, Necrosis                   | 2  3     3  2  3                                                         |     33  2.8|
      Hippocampus, Necrosis                |                                                                          |      3  3.0|
      Thalamus, Necrosis                   |          2  2                                                            |     21  2.6|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | M  +  +  +  +  +  +  +  +  +                                             |  58        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Congestion                           |          2  3           3                                                |     21  3.0|
      Hemorrhage                           |                                                                          |      5  1.0|
      Infiltration Cellular, Histiocyte    | 1  1  1        1  1  1  1                                                |     42  1.0|
      Pigmentation                         | 1  1  1        1  1  1  1                                                |     42  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      2  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Foreign Body                         |                                                                          |      2  2.0|
      Fungus                               |                                                                          |      2     |
      Hemorrhage                           | 2                                                                        |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      5  2.4|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                            +                                             |   3        |
      Cataract                             |                                                                          |      1  3.0|
      Retina, Degeneration                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 2| 7| 7| 5| 4| 4|                                            |            |
                             DAY ON TEST   | 2| 2| 2| 1| 0| 2| 2| 0| 6| 4|                                            |            |
                                           | 9| 9| 9| 2| 6| 9| 9| 2| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    10MG/KG                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|                                            |      L     |
    HIGH FEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cyst                                 |                                                                          |      2     |
      Nephropathy                          | 1     2  1        1     1  1                                             |     23  1.4|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  M  +  +  +  +  +  +  +                                             |  58        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 1| 7| 7| 6| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 7| 3| 3| 2| 3| 3| 9| 5| 3| 3| 3| 9| 5| 3| 3| 9| 8| 9|             
                                           | 5| 6| 6| 6| 5| 6| 6| 4| 3| 6| 7| 6| 6| 4| 2| 6| 6| 6| 5| 1| 6| 6| 4| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 G/KG                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    VEHICLEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  A  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  A  +  +  A  +  +  +  A  +  +  +  A  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2  2  2              2  2              2  2  2  3           2         |             
      Basophilic Focus                     |                2                                               2         |             
      Basophilic Focus, Multifocal         |                                     2        2                           |             
      Congestion                           |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Fatty Change, Diffuse                |                                                                          |             
      Fatty Change, Focal                  |                                                 2                        |             
      Fatty Change, Multifocal             |                                                                          |             
      Fibrosis                             |                         2                                                |             
      Hepatodiaphragmatic Nodule           |                                     X                 X                  |             
      Hyperplasia, Multifocal, Nodular     |                                                                      2   |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                  1           1           1               |             
      Leukocytosis                         |    3           1                                                         |             
      Necrosis, Focal                      |                         3                                                |             
      Necrosis, Multifocal                 |                               2                                          |             
      Pigmentation                         |          2                                                               |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               | 2  2  2  2  2  2  2  2  2  2  2  2  2  3  3  2  2  2  2     3  2  3     2|             
      Centrilobular, Hemorrhage            |                                                                          |             
      Centrilobular, Necrosis              |                                                                         3|             
      Periportal, Fatty Change             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +  +                                         +|             
      Fat, Necrosis, Focal                 |                            3                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Acinus, Atrophy                      | 3        2  3  1  3              1  2     2  2              2  1     2   |             
      Acinus, Hyperplasia, Focal           | 2                    2                 2                                 |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                      2   |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 1| 7| 7| 6| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 7| 3| 3| 2| 3| 3| 9| 5| 3| 3| 3| 9| 5| 3| 3| 9| 8| 9|             
                                           | 5| 6| 6| 6| 5| 6| 6| 4| 3| 6| 7| 6| 6| 4| 2| 6| 6| 6| 5| 1| 6| 6| 4| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 G/KG                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    VEHICLEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 | 1        1        1     1  1     1  1  1  2  1  1  1        1  1  1      |             
      Erosion                              |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2        2     2  1  2     2  2  2  1  2  2  2  1  3        2  2  2  2   |             
      Atrium, Dilatation                   |                                                       4                  |             
      Atrium, Thrombosis                   |                               3                 4           4           4|             
      Myocardium, Degeneration, Hyaline    |                                                          1               |             
      Valve, Inflammation, Suppurative     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Focal                   |          2                                         1        2     2  1   |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |    2  2        2                    1                          2         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |       2  3     2                 1           2  2                 2      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  M  M  +  +  +  +  M  M  +  +  +  +  M  +  +  +  +  M  M  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          2                                                               |             
      Hemorrhage                           |                                                                          |             
      Pigmentation, Hemosiderin            | 2                                2                                       |             
      Pars Distalis, Hyperplasia, Focal    |                            2                                             |             
      Pars Distalis, Hyperplasia           |    3                                                                     |             
      Pars Distalis, Hyperplasia,          |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Ultimobranchial Cyst                 |                            X                                             |             
      C-Cell, Hyperplasia                  |          3                          2        1                           |             
      Follicle, Cyst                       |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 1| 7| 7| 6| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 7| 3| 3| 2| 3| 3| 9| 5| 3| 3| 3| 9| 5| 3| 3| 9| 8| 9|             
                                           | 5| 6| 6| 6| 5| 6| 6| 4| 3| 6| 7| 6| 6| 4| 2| 6| 6| 6| 5| 1| 6| 6| 4| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 G/KG                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    VEHICLEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia, Focal, Glandular        |                                                                          |             
      Inflammation, Chronic Active         | 2     4        2           2     2                    4     2            |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 2        2                    3              2                 4         |             
      Epithelium, Hyperplasia, Focal       |    2  2                                2                          2      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          3                                                               |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypospermia                          |                                                             3            |             
      Arteriole, Inflammation, Necrotizing |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation, Hemosiderin            |                                     2                                    |             
      Mediastinal, Hemorrhage              |                2        2                                                |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Mast Cell                       |                                                                   2      |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                                                   2      |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                                                                          |             
      Mediastinal, Sinus, Ectasia          |                         3                                                |             
      Mesenteric, Hemorrhage               |                         2                                                |             
      Mesenteric, Sinus, Ectasia           | 3     2  2                             2                       4         |             
      Pancreatic, Hemorrhage               |                                                                          |             
      Pancreatic, Sinus, Ectasia           |                                     3                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +|             
      Degeneration, Cystic                 |                                              3                           |             
      Hemorrhage                           |                                     2           2                        |             
      Sinus, Ectasia                       |                            3                       2                 2   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |       X                                                                  |             
      Fibrosis, Diffuse                    |                         3                                                |             
      Fibrosis, Focal                      |                                                 2                        |             
      Fibrosis, Multifocal                 |                                        3                                 |             
      Hematopoietic Cell Proliferation     |                                                                         3|             
      Red Pulp, Atrophy                    |                                     4                                    |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  M|             
      Ectopic Tissue                       |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 1| 7| 7| 6| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 7| 3| 3| 2| 3| 3| 9| 5| 3| 3| 3| 9| 5| 3| 3| 9| 8| 9|             
                                           | 5| 6| 6| 6| 5| 6| 6| 4| 3| 6| 7| 6| 6| 4| 2| 6| 6| 6| 5| 1| 6| 6| 4| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 G/KG                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    VEHICLEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |             2                                         3                  |             
      Epithelial Cell, Hyperplasia         | 1  2  2        2  2  2     3        2  2  2  2                 2  2      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  M  M  M  +  A  +  +  +  M  +  +  +  +  M  M  +  +  M  +|             
      Galactocele                          |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                           4                          3   |             
      Hydrocephalus                        |                                                          4               |             
      Inflammation, Chronic                |                                                          3               |             
      Mineralization                       |                                                                          |             
      Cerebrum, Inflammation, Focal,       |                                                                          |             
          Suppurative                      |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |             3                                         4                  |             
      Hemorrhage                           |                            1                                      2      |             
      Infiltration Cellular, Histiocyte    |       3        1                             1                           |             
      Inflammation, Focal, Granulomatous   |                         2                                                |             
      Inflammation, Multifocal, Suppurative|                                                                          |             
      Leukocytosis                         |                                                                         2|             
      Necrosis, Focal                      |                                                                          |             
      Pigmentation                         |                2        3                                                |             
      Pigmentation, Hemoglobin             |                            1                                             |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                     3  2     2                           |             
      Bronchiole, Inflammation, Suppurative|                                                                          |             
      Bronchus, Inflammation, Suppurative  |                                                                          |             
      Interstitium, Inflammation           |       3                    1                                   1         |             
      Peribronchiolar, Alveolus,           |                                                                          |             
          Inflammation, Suppurative        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 1| 7| 7| 6| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 7| 3| 3| 2| 3| 3| 9| 5| 3| 3| 3| 9| 5| 3| 3| 9| 8| 9|             
                                           | 5| 6| 6| 6| 5| 6| 6| 4| 3| 6| 7| 6| 6| 4| 2| 6| 6| 6| 5| 1| 6| 6| 4| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 G/KG                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    VEHICLEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Fungus                               |                                           X                              |             
      Hemorrhage                           |                            2        2        2                           |             
      Hyperkeratosis, Focal                |                                           3                              |             
      Inflammation, Chronic Active         |                                           2                              |             
      Inflammation, Suppurative            |                                                                   2  2   |             
      Sinus, Inflammation, Suppurative     |                                                          3               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +     A     +                    +               |             
      Cataract                             |                                                                          |             
      Necrosis                             |                                     4                                    |             
      Conjunctiva, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                          3               |             
      Retina, Degeneration                 |                                                                          |             
      Sclera, Metaplasia, Osseous          |                                     3                                    |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       X           X                          X                           |             
      Inflammation, Multifocal, Suppurative|                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Nephropathy                          | 3  3  3  2  2  3  3  3  2  3     3  3  3  3  3  3  3  1     2  3  2  3  2|             
      Pigmentation                         |                         3                                         3     2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                              1                           |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 6| 7| 6| 6| 5| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 8| 3| 2| 2| 6| 3| 1| 5| 8| 4| 3| 3| 3| 9| 9| 3| 0| 0| 9| 7|             
                                           | 6| 6| 6| 6| 0| 1| 6| 7| 6| 1| 6| 9| 8| 9| 9| 6| 6| 6| 7| 3| 6| 3| 3| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    0 G/KG                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    VEHICLEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  A  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  A  +  +  +  A  A  A  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A  +  +  +  A  A  A  +  +  +  +  A  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  +  +  A  A  A  +  +  +  A  A  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  M  +  +  +  A  +  +  +  A  A  A  +  +  +  A  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2                             2                 2                     |             
      Basophilic Focus                     |                                                                          |             
      Basophilic Focus, Multifocal         |                                                                          |             
      Congestion                           |                                                       2                  |             
      Degeneration, Cystic                 |    3                                                                     |             
      Fatty Change, Diffuse                |                                                                          |             
      Fatty Change, Focal                  |                                                                          |             
      Fatty Change, Multifocal             |                      1                                                   |             
      Fibrosis                             |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia, Multifocal, Nodular     |                                                                          |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |       1                                                                  |             
      Leukocytosis                         |          2                                                              2|             
      Necrosis, Focal                      |                                                                          |             
      Necrosis, Multifocal                 |                                                                          |             
      Pigmentation                         |                                                                          |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               | 3  2  2  2  2  2  3  2  2  3  2  3     3     2  2  2  2  3  3     3  3  2|             
      Centrilobular, Hemorrhage            |                                                                          |             
      Centrilobular, Necrosis              |                                     2                                    |             
      Periportal, Fatty Change             |                3                                                         |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                    +           +  +  +           +            |             
      Fat, Necrosis, Focal                 |          4                    4              3  4           4            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration, Focal        |                         2                                                |             
      Acinus, Atrophy                      |    2                                            2              3         |             
      Acinus, Hyperplasia, Focal           | 2  2                                                                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                              2                           |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                        3                       3  3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 6| 7| 6| 6| 5| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 8| 3| 2| 2| 6| 3| 1| 5| 8| 4| 3| 3| 3| 9| 9| 3| 0| 0| 9| 7|             
                                           | 6| 6| 6| 6| 0| 1| 6| 7| 6| 1| 6| 9| 8| 9| 9| 6| 6| 6| 7| 3| 6| 3| 3| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    0 G/KG                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    VEHICLEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 | 1  1  1  1  1  1  1  1     1  1  1           1     1        2  1  1  1  1|             
      Erosion                              |                                                          2               |             
      Inflammation, Chronic Active         |                                                    2                     |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2     2     2        1     2        2  2  2  1  2  2  2  2  2  2  2   |             
      Atrium, Dilatation                   |                                                                          |             
      Atrium, Thrombosis                   |                                        3                    4     4  4   |             
      Myocardium, Degeneration, Hyaline    |                                                                          |             
      Valve, Inflammation, Suppurative     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                       4                  |             
      Hemorrhage                           |                                                       3                  |             
      Hyperplasia, Focal                   |                                     2                                    |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |             1  2  2  2              2                          2  2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia, Focal                   |    2  2  2  3        2        3                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  M  +  +  M  +  +  +  M  +  +  +  M  M  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                    2                 2   |             
      Hemorrhage                           |                                                                         4|             
      Pigmentation, Hemosiderin            |                                                    2                     |             
      Pars Distalis, Hyperplasia, Focal    |                                                                   2      |             
      Pars Distalis, Hyperplasia           |                                                                          |             
      Pars Distalis, Hyperplasia,          |                                                                          |             
          Multifocal                       |                   2                                                      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |          2                                                               |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 6| 7| 6| 6| 5| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 8| 3| 2| 2| 6| 3| 1| 5| 8| 4| 3| 3| 3| 9| 9| 3| 0| 0| 9| 7|             
                                           | 6| 6| 6| 6| 0| 1| 6| 7| 6| 1| 6| 9| 8| 9| 9| 6| 6| 6| 7| 3| 6| 3| 3| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    0 G/KG                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    VEHICLEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Glandular        |                                                                      2   |             
      Inflammation, Chronic Active         |    1  1  2     2              1                       2  2  2  2  2  4   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    2           3                                3  2           2  4  4   |             
      Epithelium, Hyperplasia, Focal       | 2  2                       2                 2                           |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypospermia                          |             3  4                                                         |             
      Arteriole, Inflammation, Necrotizing |                                                       2                  |             
      Interstitial Cell, Hyperplasia       | 2  1           2     2                 2        2        2        3      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                3                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation, Hemosiderin            |                                                                          |             
      Mediastinal, Hemorrhage              |                      2                                            2      |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Mast Cell                       |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                                 2                        |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                                                                          |             
      Mediastinal, Sinus, Ectasia          |                                                                          |             
      Mesenteric, Hemorrhage               |                                                    2                     |             
      Mesenteric, Sinus, Ectasia           | 3                                                                        |             
      Pancreatic, Hemorrhage               |                                                                          |             
      Pancreatic, Sinus, Ectasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Sinus, Ectasia                       |                      3                          3        2        2      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                                 X                 X     X|             
      Fibrosis, Diffuse                    |                                                                          |             
      Fibrosis, Focal                      | 3                                      3           2     3  2  2         |             
      Fibrosis, Multifocal                 |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Red Pulp, Atrophy                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  M  +  +  M  +  +  +  +  +  M  +  +  +  +  M  M  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 6| 7| 6| 6| 5| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 8| 3| 2| 2| 6| 3| 1| 5| 8| 4| 3| 3| 3| 9| 9| 3| 0| 0| 9| 7|             
                                           | 6| 6| 6| 6| 0| 1| 6| 7| 6| 1| 6| 9| 8| 9| 9| 6| 6| 6| 7| 3| 6| 3| 3| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    0 G/KG                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    VEHICLEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Epithelial Cell, Hyperplasia         |          2        2     1              2     2        2     1  2  2     1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +|             
      Galactocele                          |    X                                                                     |             
      Inflammation, Granulomatous          |    3                                                                     |             
      Duct, Ectasia                        |                2                                3     3                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                            4              3                    3  3      |             
      Hydrocephalus                        |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                         2                                                |             
      Cerebrum, Inflammation, Focal,       |                                                                          |             
          Suppurative                      |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                         2                             4                 2|             
      Hemorrhage                           |       1                                                                  |             
      Infiltration Cellular, Histiocyte    |                1              1                 1        1  2  2         |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Inflammation, Multifocal, Suppurative|                                                                          |             
      Leukocytosis                         |          2                                                               |             
      Necrosis, Focal                      |                                                                   3      |             
      Pigmentation                         |                1              1                 1        1               |             
      Pigmentation, Hemoglobin             |                                                                          |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           | 3     3  2                    2  3                                       |             
      Bronchiole, Inflammation, Suppurative|                      4                                                   |             
      Bronchus, Inflammation, Suppurative  |                                                                          |             
      Interstitium, Inflammation           |                                                                          |             
      Peribronchiolar, Alveolus,           |                                                                          |             
          Inflammation, Suppurative        |                      4                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 6| 7| 6| 6| 5| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 8| 3| 2| 2| 6| 3| 1| 5| 8| 4| 3| 3| 3| 9| 9| 3| 0| 0| 9| 7|             
                                           | 6| 6| 6| 6| 0| 1| 6| 7| 6| 1| 6| 9| 8| 9| 9| 6| 6| 6| 7| 3| 6| 3| 3| 5| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    0 G/KG                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    VEHICLEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                       3                  |             
      Fungus                               |                                                       X                  |             
      Hemorrhage                           | 3                                                                        |             
      Hyperkeratosis, Focal                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                               2                       2           2      |             
      Sinus, Inflammation, Suppurative     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |    +  +              +                                                   |             
                                            __________________________________________________________________________|             
   Eye                                     |    +  +     +              +                                             |             
      Cataract                             |    4  4                                                                  |             
      Necrosis                             |                                                                          |             
      Conjunctiva, Inflammation, Chronic   |                                                                          |             
          Active                           |    2                                                                     |             
      Retina, Degeneration                 |    3  4                                                                  |             
      Sclera, Metaplasia, Osseous          |                            2                                             |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                      +                                               +   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                 X                        |             
      Inflammation, Multifocal, Suppurative|                                                                          |             
      Necrosis, Focal                      |                                                                      2   |             
      Nephropathy                          | 3  3  2  3  2  4  3  3  2  2  2  2  2  2  2  3  3  3  4  2  3  3  3  2  3|             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |    1                                                                    2|             
      Inflammation, Suppurative            |                            4                                             |             
      Ulcer                                |                            4                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 3| 6| 6| 6| 6| 5|                                            |            |
                             DAY ON TEST   | 1| 4| 0| 6| 0| 9| 7| 5| 0| 5|                                            |            |
                                           | 1| 0| 3| 8| 0| 0| 8| 4| 4| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0 G/KG                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    VEHICLEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  A  A  A  +  A  A  +  +                                             |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  A  A  +  A  A  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  A  A  A  +  A  A  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  A  A  A  +  A  A  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  A  A  A  +  A  A  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  A  A  +  A  A  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  A  A  +  A  A  +  +                                             |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  A  A  +  A  A  +  +                                             |  42        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |     13  2.1|
      Basophilic Focus                     |                                                                          |      2  2.0|
      Basophilic Focus, Multifocal         |                                                                          |      2  2.0|
      Congestion                           |                                                                          |      1  2.0|
      Degeneration, Cystic                 | 3              2  2                                                      |      4  2.5|
      Fatty Change, Diffuse                |                      4                                                   |      1  4.0|
      Fatty Change, Focal                  |                                                                          |      1  2.0|
      Fatty Change, Multifocal             |                                                                          |      1  1.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |             X                                                            |      3     |
      Hyperplasia, Multifocal, Nodular     |                                                                          |      1  2.0|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |                                                                          |      4  1.0|
      Leukocytosis                         |    2                                                                     |      5  2.0|
      Necrosis, Focal                      |                                                                          |      1  3.0|
      Necrosis, Multifocal                 |       2                                                                  |      2  2.0|
      Pigmentation                         |                                                                          |      1  2.0|
      Thrombosis                           |                            4                                             |      1  4.0|
      Bile Duct, Hyperplasia               | 3  2  2  2     3  2     3  2                                             |     53  2.3|
      Centrilobular, Hemorrhage            |                            3                                             |      1  3.0|
      Centrilobular, Necrosis              |                                                                          |      2  2.5|
      Periportal, Fatty Change             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   9        |
      Fat, Necrosis, Focal                 |                                                                          |      6  3.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  A  +  +  +  A  +  +  +                                             |  57        |
      Cytoplasmic Alteration, Focal        |                                                                          |      1  2.0|
      Acinus, Atrophy                      |                2     1  2                                                |     18  2.0|
      Acinus, Hyperplasia, Focal           |                                                                          |      5  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 3| 6| 6| 6| 6| 5|                                            |            |
                             DAY ON TEST   | 1| 4| 0| 6| 0| 9| 7| 5| 0| 5|                                            |            |
                                           | 1| 0| 3| 8| 0| 0| 8| 4| 4| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0 G/KG                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    VEHICLEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Acinus, Atrophy                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Inflammation, Chronic Active         |                         3                                                |      2  2.5|
      Ulcer                                | 4                          1                                             |      5  2.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Degeneration, Cystic                 | 2              1     1  1                                                |     37  1.1|
      Erosion                              |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       | 2     2  2     2  2                                                      |     40  1.9|
      Atrium, Dilatation                   |                                                                          |      1  4.0|
      Atrium, Thrombosis                   | 4  4                                                                     |     10  3.8|
      Myocardium, Degeneration, Hyaline    |                                                                          |      1  1.0|
      Valve, Inflammation, Suppurative     | 4                                                                        |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      1  4.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Focal                   |                            1                                             |      7  1.6|
      Necrosis                             |                         3                                                |      1  3.0|
      Vacuolization Cytoplasmic, Focal     | 2  2                 2                                                   |     15  1.9|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  M  +  +  M  +  M  +  +                                             |  55        |
      Hyperplasia, Focal                   |    2     2                                                               |     15  2.1|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  A  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  M  +  +  +  M  +  +                                             |  41        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  A  +  +  +  +  +  +  +                                             |  59        |
      Angiectasis                          |                                                                          |      3  2.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Pigmentation, Hemosiderin            |    1                                                                     |      4  1.8|
      Pars Distalis, Hyperplasia, Focal    |                         2  2                                             |      4  2.0|
      Pars Distalis, Hyperplasia           |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia,          |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 3| 6| 6| 6| 6| 5|                                            |            |
                             DAY ON TEST   | 1| 4| 0| 6| 0| 9| 7| 5| 0| 5|                                            |            |
                                           | 1| 0| 3| 8| 0| 0| 8| 4| 4| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0 G/KG                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    VEHICLEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  A  A  +  +  +  +  +  +                                             |  57        |
      Ultimobranchial Cyst                 |                                                                          |      1     |
      C-Cell, Hyperplasia                  |                2                                                         |      5  2.0|
      Follicle, Cyst                       |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                            +                                             |   1        |
      Thrombosis                           |                            4                                             |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia, Focal, Glandular        |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                   2        2                                             |     20  2.2|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         |                         2                                                |     13  2.7|
      Epithelium, Hyperplasia, Focal       |                                                                          |      8  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Atrophy                              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hypospermia                          |    4     4                                                               |      5  3.6|
      Arteriole, Inflammation, Necrotizing |                                                                          |      1  2.0|
      Interstitial Cell, Hyperplasia       |                         2                                                |     10  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  A  +  +  +  +  +  +  +                                             |  59        |
      Atrophy                              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  M  +  +  +  +  +                                             |  58        |
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Mediastinal, Hemorrhage              | 3                                                                        |      5  2.2|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Mast Cell                       |                                                                          |      1  2.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                                                                          |      2  2.0|
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      |                            4                                             |      1  4.0|
      Mediastinal, Sinus, Ectasia          |    2                                                                     |      2  2.5|
      Mesenteric, Hemorrhage               | 3                                                                        |      3  2.3|
      Mesenteric, Sinus, Ectasia           |                                                                          |      6  2.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 3| 6| 6| 6| 6| 5|                                            |            |
                             DAY ON TEST   | 1| 4| 0| 6| 0| 9| 7| 5| 0| 5|                                            |            |
                                           | 1| 0| 3| 8| 0| 0| 8| 4| 4| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0 G/KG                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    VEHICLEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pancreatic, Hemorrhage               |                2                                                         |      1  2.0|
      Pancreatic, Sinus, Ectasia           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  +                                             |  55        |
      Degeneration, Cystic                 |                                                                          |      1  3.0|
      Hemorrhage                           | 3                                                                        |      3  2.3|
      Sinus, Ectasia                       |                                                                          |      7  2.4|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ectopic Tissue                       |                                                                          |      4     |
      Fibrosis, Diffuse                    | 4              4                                                         |      3  3.7|
      Fibrosis, Focal                      |                                                                          |      7  2.4|
      Fibrosis, Multifocal                 |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Red Pulp, Atrophy                    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Ectopic Tissue                       |                                                                          |      1     |
      Hemorrhage                           |                                                                          |      2  2.5|
      Epithelial Cell, Hyperplasia         | 2  2  2     1  2           2                                             |     29  1.9|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  +  +  +  A  M  +                                             |  47        |
      Galactocele                          |                                                                          |      1     |
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
      Duct, Ectasia                        |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  M  +  +                                             |  58        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                            +                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |       3                                                                  |      7  3.3|
      Hydrocephalus                        |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  2.0|
      Cerebrum, Inflammation, Focal,       |                                                                          |            |
          Suppurative                      | 1                                                                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  M  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hemorrhage                           |       3                                                                  |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 3| 6| 6| 6| 6| 5|                                            |            |
                             DAY ON TEST   | 1| 4| 0| 6| 0| 9| 7| 5| 0| 5|                                            |            |
                                           | 1| 0| 3| 8| 0| 0| 8| 4| 4| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0 G/KG                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    VEHICLEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |             3                                                            |      6  3.0|
      Hemorrhage                           |                      2                                                   |      4  1.5|
      Infiltration Cellular, Histiocyte    |                1     1                                                   |     11  1.4|
      Inflammation, Focal, Granulomatous   |                                                                          |      1  2.0|
      Inflammation, Multifocal, Suppurative| 2                                                                        |      1  2.0|
      Leukocytosis                         |                                                                          |      2  2.0|
      Necrosis, Focal                      |                                                                          |      1  3.0|
      Pigmentation                         |                1     1                                                   |      8  1.4|
      Pigmentation, Hemoglobin             |                                                                          |      1  1.0|
      Thrombosis                           | 2                                                                        |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      8  2.5|
      Bronchiole, Inflammation, Suppurative|       4                                                                  |      2  4.0|
      Bronchus, Inflammation, Suppurative  |       4                                                                  |      1  4.0|
      Interstitium, Inflammation           |                                                                          |      3  1.7|
      Peribronchiolar, Alveolus,           |                                                                          |            |
          Inflammation, Suppurative        |       4                                                                  |      2  4.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  A  +  +  +  +  +  +  +                                             |  59        |
      Congestion                           |                                                                          |      1  3.0|
      Fungus                               |          X                                                               |      3     |
      Hemorrhage                           |                                                                          |      4  2.3|
      Hyperkeratosis, Focal                |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Inflammation, Suppurative            |          2                                                               |      6  2.0|
      Sinus, Inflammation, Suppurative     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +     +  +  +  +                                             |  58        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |    +                                                                     |   4        |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                    +  +                                             |  10        |
      Cataract                             |    3                    4                                                |      4  3.8|
      Necrosis                             |                                                                          |      1  4.0|
      Conjunctiva, Inflammation, Chronic   |                                                                          |            |
          Active                           |                                                                          |      2  2.5|
      Retina, Degeneration                 |    3                    4                                                |      4  3.5|
      Sclera, Metaplasia, Osseous          |    2                    2  2                                             |      5  2.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6| 5| 3| 6| 6| 6| 6| 5|                                            |            |
                             DAY ON TEST   | 1| 4| 0| 6| 0| 9| 7| 5| 0| 5|                                            |            |
                                           | 1| 0| 3| 8| 0| 0| 8| 4| 4| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0 G/KG                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    VEHICLEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |    +                                                                     |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      4     |
      Inflammation, Multifocal, Suppurative| 2                                                                        |      1  2.0|
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Nephropathy                          | 2  2  2  2     3  2  2  2  2                                             |     57  2.6|
      Pigmentation                         |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      3  1.3|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Ulcer                                |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 2| 1| 0| 9| 8| 2| 3| 1| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 9| 1|             
                                           | 9| 7| 4| 3| 3| 9| 0| 6| 7| 3| 0| 0| 0| 0| 2| 0| 0| 0| 9| 7| 0| 0| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5 MG/KG                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A|             
      Epithelium, Hyperplasia, Focal       |                                           2                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                             2            |             
      Basophilic Focus, Focal              |                                                                          |             
      Basophilic Focus, Multifocal         |                                  2                                       |             
      Eosinophilic Focus, Focal            |                               2                                          |             
      Eosinophilic Focus, Multifocal       |                                                                   2      |             
      Fatty Change, Diffuse                |                         3                                                |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Leukocytosis                         |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Bile Duct, Hyperplasia               | 2  2     2  3  2  2  2     2  3  2  2  2  3  2  3  2  2  2  2  3  2  2  2|             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +              +                 +  +                             +   |             
      Inflammation, Focal, Granulomatous   |                   3                                                      |             
      Necrosis, Focal                      |                                                                          |             
      Fat, Necrosis, Focal                 |    4                                4  4                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration, Multifocal   |                                                                          |             
      Acinus, Atrophy                      | 2  2                 2              2     2  2           1  2  1  2     2|             
      Artery, Inflammation, Chronic        |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                2         |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |             4                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 | 1  1  1  1  2  1  2  1  1     1  2  2  2     2  2  2     1  2  2  2  2   |             
      Degeneration                         |    1                                                                     |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 2| 1| 0| 9| 8| 2| 3| 1| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 9| 1|             
                                           | 9| 7| 4| 3| 3| 9| 0| 6| 7| 3| 0| 0| 0| 0| 2| 0| 0| 0| 9| 7| 0| 0| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5 MG/KG                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                      3                                                   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Dysplasia                            |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2                       2  2  2     2  2  2  2  2  2        2         |             
      Thrombosis                           |                                                                      X   |             
      Atrium, Thrombosis                   |                                           4                              |             
      Myocardium, Atrium, Inflammation,    |                                                                          |             
           Chronic                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia, Focal                   |                   1                                2           2     2   |             
      Hypertrophy, Focal                   |                   1                                                      |             
      Necrosis, Multifocal                 |                                                                      3   |             
      Vacuolization Cytoplasmic, Focal     |    2           1     2              1                                    |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                         2           1  2  1        2           3         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  M  +  M  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                               2                                          |             
      Cyst                                 |                                                          X               |             
      Hemorrhage                           |          2                                                               |             
      Pigmentation, Hemosiderin            |                                                    2                     |             
      Pigmentation, Hemoglobin             |          2                                                               |             
      Pars Distalis, Hyperplasia, Focal    |                                                    2        2            |             
      Pars Nervosa, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                              2                           |             
      Follicle, Cyst                       |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 2| 1| 0| 9| 8| 2| 3| 1| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 9| 1|             
                                           | 9| 7| 4| 3| 3| 9| 0| 6| 7| 3| 0| 0| 0| 0| 2| 0| 0| 0| 9| 7| 0| 0| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5 MG/KG                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Focal, Glandular        |                                                                          |             
      Inflammation, Chronic Active         | 2        2        2  2           2                                       |             
      Duct, Ectasia                        |                         3                                                |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 3     2           3                                                      |             
      Inflammation, Suppurative            |                                                                          |             
      Epithelium, Hyperplasia, Focal       |             2                          2                                 |             
      Serosa, Inflammation, Suppurative    |                                                                      3   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                      3                                                   |             
      Inflammation, Chronic Active         |                                                                          |             
      Serosa, Inflammation, Suppurative    |                                                                      3   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypospermia                          | 3           4                                            4               |             
      Interstitial Cell, Hyperplasia       | 2                          2              2                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation, Hemosiderin            |                2                                                         |             
      Mediastinal, Hematopoietic Cell      |                                                                          |             
          Proliferation                    |                                                                      2   |             
      Mediastinal, Hemorrhage              | 2        3     2                                      3              3   |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                                                                          |             
      Mediastinal, Sinus, Ectasia          |                                                                          |             
      Mesenteric, Congestion               |                                                                         4|             
      Mesenteric, Hemorrhage               |                                                                2  2     3|             
      Mesenteric, Sinus, Ectasia           |    2                                   2                                3|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             |                                        3           2           3         |             
      Sinus, Ectasia                       | 2     2        2  2                    3           2                 2   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                                                          |             
      Fibrosis, Diffuse                    |                                                                   3  3   |             
      Fibrosis, Focal                      |                                                 3              2         |             
      Fibrosis, Multifocal                 |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |          3                                                               |             
      Hyperplasia, Re Cell                 |       3                                                                  |             
      Necrosis, Focal                      |                                                                          |             
      Necrosis, Multifocal                 |                                                                          |             
      Red Pulp, Atrophy                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 2| 1| 0| 9| 8| 2| 3| 1| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 9| 1|             
                                           | 9| 7| 4| 3| 3| 9| 0| 6| 7| 3| 0| 0| 0| 0| 2| 0| 0| 0| 9| 7| 0| 0| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5 MG/KG                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  M  M  +  M  +  +  +  +  M  +  M  M  +  M  +  +  +  +|             
      Cyst                                 |                   X                                                      |             
      Hemorrhage                           |                                                                          |             
      Epithelial Cell, Hyperplasia         | 2  2  2        2  2        1     2  2     2     2        2     2         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Nodular                 |             2                                                            |             
      Inflammation, Granulomatous          |                                                                          |             
      Duct, Ectasia                        |                         2                             3                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                      2                                                   |             
      Brain Stem, Compression              |                                                                          |             
      Cerebrum, Necrosis                   |                                                                          |             
      Medulla, Gliosis                     |                                                    1                     |             
      Thalamus, Necrosis                   |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |          2                 2                                             |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 2              1  1              1                 1     1  1           1|             
      Pigmentation                         | 1              1  1              1                 1     1  1           1|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Interstitium, Inflammation, Focal    |                                                                          |             
      Interstitium, Inflammation           | 2                                                                        |             
      Peribronchiolar, Foreign Body        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                                                                          |             
      Hemorrhage                           |                            2                                             |             
      Inflammation, Suppurative            |       2                                   3                              |             
      Sinus, Inflammation, Chronic         |                                                                          |             
      Sinus, Inflammation, Chronic Active  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 2| 1| 0| 9| 8| 2| 3| 1| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 9| 1|             
                                           | 9| 7| 4| 3| 3| 9| 0| 6| 7| 3| 0| 0| 0| 0| 2| 0| 0| 0| 9| 7| 0| 0| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5 MG/KG                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                            +                                             |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                    +                    A|             
      Cataract                             |                                                    3                     |             
      Retina, Degeneration                 |                                                    3                     |             
      Sclera, Metaplasia, Osseous          |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +                                                |             
      Pigmentation, Porphyrin              |                         3                                                |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Nephropathy                          | 2  2  2  2  1  2  2  3  3  1  2  2  1  2  2  3  2  2  3  1  3  3  4  3   |             
      Pigmentation                         |                                           3              2               |             
      Pelvis, Epithelium, Hyperplasia,     |                                                                          |             
           Focal                           |          2                                                               |             
      Renal Tubule, Necrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 2| 7| 7| 6| 6| 5| 7| 7| 6| 5| 2| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 4| 7| 2| 3| 1| 7| 3| 7| 3| 3| 4| 9| 2| 3| 3| 9| 4| 0| 3| 3| 3| 3| 3|             
                                           | 0| 3| 8| 9| 7| 0| 2| 3| 9| 6| 0| 0| 0| 1| 6| 0| 0| 8| 1| 2| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5 MG/KG                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia, Focal       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  A  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  A  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   2           2  2           2  2                        |             
      Basophilic Focus, Focal              |                                     2                                    |             
      Basophilic Focus, Multifocal         |                2              2                                          |             
      Eosinophilic Focus, Focal            |                                                                          |             
      Eosinophilic Focus, Multifocal       |                                                                          |             
      Fatty Change, Diffuse                |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                 X                        |             
      Leukocytosis                         |                               2  2  2                                    |             
      Necrosis, Focal                      |                                           2                              |             
      Bile Duct, Hyperplasia               | 2  3  3  3     2  2  3  2  3  2  2  2  2     3  2  3  2  2  2  2  2  2  2|             
      Centrilobular, Necrosis              |    3  3                                                                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +  +              +     +              +           +  +   |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Fat, Necrosis, Focal                 |                4  3              4     3              2           4  4   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration, Multifocal   |    2                                                                     |             
      Acinus, Atrophy                      |       2           3        1  1     1              3        2            |             
      Artery, Inflammation, Chronic        |                                                                      3   |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Chronic Active         |                                                                3         |             
      Ulcer                                |                      3                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 | 2  2  2  1     2  1     1     2  2  2        2  1  2  2     2  2  2  2  1|             
      Degeneration                         |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                    2                     |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 2| 7| 7| 6| 6| 5| 7| 7| 6| 5| 2| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 4| 7| 2| 3| 1| 7| 3| 7| 3| 3| 4| 9| 2| 3| 3| 9| 4| 0| 3| 3| 3| 3| 3|             
                                           | 0| 3| 8| 9| 7| 0| 2| 3| 9| 6| 0| 0| 0| 1| 6| 0| 0| 8| 1| 2| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5 MG/KG                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                    +                     |             
      Dysplasia                            |                                                    3                     |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Suppurative                     |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2              2        2        2  2           2  1        2  1  2   |             
      Thrombosis                           |                                                                          |             
      Atrium, Thrombosis                   |    3  4                                                                  |             
      Myocardium, Atrium, Inflammation,    |                                                                          |             
           Chronic                         |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 3                                               4                        |             
      Hyperplasia, Focal                   |                                  2                                       |             
      Hypertrophy, Focal                   |                                                                          |             
      Necrosis, Multifocal                 |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                2                       1     2  2              2  2     1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +|             
      Hyperplasia, Focal                   |       2  2                                      2  1                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  M  +  +  M  +  +  +  +  +  M  +  +  M  +  +  +  M  +  M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 | X                                               X                        |             
      Hemorrhage                           |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Pigmentation, Hemoglobin             |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |    2                          2     2           2                    2   |             
      Pars Nervosa, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      C-Cell, Hyperplasia                  | 2                             2                                          |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 2| 7| 7| 6| 6| 5| 7| 7| 6| 5| 2| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 4| 7| 2| 3| 1| 7| 3| 7| 3| 3| 4| 9| 2| 3| 3| 9| 4| 0| 3| 3| 3| 3| 3|             
                                           | 0| 3| 8| 9| 7| 0| 2| 3| 9| 6| 0| 0| 0| 1| 6| 0| 0| 8| 1| 2| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5 MG/KG                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Focal, Glandular        |                            3                                             |             
      Inflammation, Chronic Active         |                                     1           3              2         |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                    3                     |             
      Inflammation, Suppurative            |                                           3                              |             
      Epithelium, Hyperplasia, Focal       |    2                             2  2           2              2         |             
      Serosa, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                3         |             
      Inflammation, Chronic Active         |                                                                          |             
      Serosa, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypospermia                          |       4                                            4           4     4   |             
      Interstitial Cell, Hyperplasia       |       2  2              2  2                       2           2        2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                           3                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +|             
      Pigmentation, Hemosiderin            |                                                                          |             
      Mediastinal, Hematopoietic Cell      |                                                                          |             
          Proliferation                    |                                                                          |             
      Mediastinal, Hemorrhage              |                            3     2              2                        |             
      Mediastinal, Pigmentation,           |                                                                          |             
          Hemosiderin                      |                                  2                                2      |             
      Mediastinal, Sinus, Ectasia          |                      2        3                                          |             
      Mesenteric, Congestion               |                                                                          |             
      Mesenteric, Hemorrhage               |                      3                    3                              |             
      Mesenteric, Sinus, Ectasia           |                               3                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +|             
      Hyperplasia, Plasma Cell             |                            3                                             |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       | X                                                                        |             
      Fibrosis, Diffuse                    |                                                                          |             
      Fibrosis, Focal                      |       2                                            3                    2|             
      Fibrosis, Multifocal                 |                                              3                           |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Re Cell                 |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Necrosis, Multifocal                 |                                                                          |             
      Red Pulp, Atrophy                    |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 2| 7| 7| 6| 6| 5| 7| 7| 6| 5| 2| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 4| 7| 2| 3| 1| 7| 3| 7| 3| 3| 4| 9| 2| 3| 3| 9| 4| 0| 3| 3| 3| 3| 3|             
                                           | 0| 3| 8| 9| 7| 0| 2| 3| 9| 6| 0| 0| 0| 1| 6| 0| 0| 8| 1| 2| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5 MG/KG                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  M  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |             2                                                            |             
      Epithelial Cell, Hyperplasia         |    1     2     2     2     2  2  2  1     2  2  2  2  2  1  2  2     2   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  M  +  +  +  +  +  M  +  +  +  +  +  M  +  +  M  +  +  +  M  +  +  +|             
      Hyperplasia, Nodular                 |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Duct, Ectasia                        |                                        3                                 |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Brain Stem, Compression              |                                        2                                 |             
      Cerebrum, Necrosis                   |       1                                                                  |             
      Medulla, Gliosis                     |                                                                          |             
      Thalamus, Necrosis                   |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |             3                                                            |             
      Hemorrhage                           |                      2  3              2              2                  |             
      Infiltration Cellular, Histiocyte    |                      1                                1           1      |             
      Pigmentation                         |                      2                                1           1      |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           | 2                    2           2                                2      |             
      Interstitium, Inflammation, Focal    |                         1                                                |             
      Interstitium, Inflammation           |                                                                          |             
      Peribronchiolar, Foreign Body        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                         4                                                |             
      Hemorrhage                           |                         3                                                |             
      Inflammation, Suppurative            |                         3                                                |             
      Sinus, Inflammation, Chronic         |                                           2                              |             
      Sinus, Inflammation, Chronic Active  |                                                    3                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 2| 7| 7| 6| 6| 5| 7| 7| 6| 5| 2| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 2| 4| 7| 2| 3| 1| 7| 3| 7| 3| 3| 4| 9| 2| 3| 3| 9| 4| 0| 3| 3| 3| 3| 3|             
                                           | 0| 3| 8| 9| 7| 0| 2| 3| 9| 6| 0| 0| 0| 1| 6| 0| 0| 8| 1| 2| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    5 MG/KG                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                                                               |             
      Cataract                             |          2                                                               |             
      Retina, Degeneration                 |          3                                                               |             
      Sclera, Metaplasia, Osseous          |          2                                                               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Pigmentation, Porphyrin              |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                 X                        |             
      Nephropathy                          | 3  2  2  2     2  2  3  2  1  2  2  1  2     2  3  2  2  2  3  3  4  3  2|             
      Pigmentation                         |          3                                                               |             
      Pelvis, Epithelium, Hyperplasia,     |                                                                          |             
           Focal                           |                                                                          |             
      Renal Tubule, Necrosis               |                                           3                              |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                  1                          1            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 7| 7| 6| 6| 5|                                            |            |
                             DAY ON TEST   | 0| 3| 0| 8| 6| 3| 3| 9| 5| 2|                                            |            |
                                           | 2| 0| 8| 1| 0| 0| 0| 0| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |      A     |
    5 MG/KG                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |      L     |
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  53        |
      Epithelium, Hyperplasia, Focal       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  M  +  +  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  A                                             |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A  A                                             |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A                                             |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  A                                             |  51        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |             2                                                            |      7  2.0|
      Basophilic Focus, Focal              |                                                                          |      1  2.0|
      Basophilic Focus, Multifocal         |                                                                          |      3  2.0|
      Eosinophilic Focus, Focal            |                                                                          |      1  2.0|
      Eosinophilic Focus, Multifocal       |                                                                          |      1  2.0|
      Fatty Change, Diffuse                |                                                                          |      1  3.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Leukocytosis                         |                                                                          |      3  2.0|
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               | 3  2  2  2  3  2  2  2  2  2                                             |     56  2.3|
      Centrilobular, Necrosis              | 2     2                 3                                                |      5  2.6|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                                                   |  13        |
      Inflammation, Focal, Granulomatous   |                                                                          |      1  3.0|
      Necrosis, Focal                      |                      4                                                   |      1  4.0|
      Fat, Necrosis, Focal                 |                                                                          |     10  3.6|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cytoplasmic Alteration, Multifocal   |                                                                          |      1  2.0|
      Acinus, Atrophy                      | 1                       2                                                |     20  1.8|
      Artery, Inflammation, Chronic        |                                                                          |      1  3.0|
      Duct, Ectasia                        |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  M  +  +  +  +                                             |  59        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Degeneration, Cystic                 | 2  1  2  2  2     1  1  1                                                |     48  1.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 7| 7| 6| 6| 5|                                            |            |
                             DAY ON TEST   | 0| 3| 0| 8| 6| 3| 3| 9| 5| 2|                                            |            |
                                           | 2| 0| 8| 1| 0| 0| 0| 0| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |      A     |
    5 MG/KG                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |      L     |
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Degeneration                         |                                                                          |      1  1.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |    3                                                                     |      1  3.0|
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Dysplasia                            |                                                                          |      1  3.0|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       |          2              2  2                                             |     26  1.9|
      Thrombosis                           |                                                                          |      1     |
      Atrium, Thrombosis                   |             4                                                            |      4  3.8|
      Myocardium, Atrium, Inflammation,    |                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      2  3.5|
      Hyperplasia, Focal                   |                      2                                                   |      6  1.8|
      Hypertrophy, Focal                   |                                                                          |      1  1.0|
      Necrosis, Multifocal                 |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic, Focal     | 1  2              2     1                                                |     15  1.6|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  M  +  +  M  +  +  +  +  +                                             |  56        |
      Hyperplasia, Focal                   |                1                                                         |     11  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  M  M  +  +  +  +                                             |  43        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      3     |
      Hemorrhage                           |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Pigmentation, Hemoglobin             |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      7  2.0|
      Pars Nervosa, Hyperplasia            | 3                                                                        |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 7| 7| 6| 6| 5|                                            |            |
                             DAY ON TEST   | 0| 3| 0| 8| 6| 3| 3| 9| 5| 2|                                            |            |
                                           | 2| 0| 8| 1| 0| 0| 0| 0| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |      A     |
    5 MG/KG                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |      L     |
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      C-Cell, Hyperplasia                  |                   2  2                                                   |      5  2.0|
      Follicle, Cyst                       |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia, Focal, Glandular        |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                   2  2                                                   |     10  2.0|
      Duct, Ectasia                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         |                                                                          |      4  2.8|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Epithelium, Hyperplasia, Focal       |    2                    2                                                |      9  2.0|
      Serosa, Inflammation, Suppurative    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      2  3.0|
      Inflammation, Chronic Active         |             4                                                            |      1  4.0|
      Serosa, Inflammation, Suppurative    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hypospermia                          |                                                                          |      7  3.9|
      Interstitial Cell, Hyperplasia       |             2                                                            |     11  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Mediastinal, Hematopoietic Cell      |                                                                          |            |
          Proliferation                    |                                                                          |      1  2.0|
      Mediastinal, Hemorrhage              |                            3                                             |      9  2.6|
      Mediastinal, Pigmentation,           |                                                                          |            |
          Hemosiderin                      |                                                                          |      2  2.0|
      Mediastinal, Sinus, Ectasia          |                                                                          |      2  2.5|
      Mesenteric, Congestion               |                                                                          |      1  4.0|
      Mesenteric, Hemorrhage               |                         3                                                |      6  2.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  74                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 7| 7| 6| 6| 5|                                            |            |
                             DAY ON TEST   | 0| 3| 0| 8| 6| 3| 3| 9| 5| 2|                                            |            |
                                           | 2| 0| 8| 1| 0| 0| 0| 0| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |      A     |
    5 MG/KG                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |      L     |
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mesenteric, Sinus, Ectasia           |                                                                          |      4  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +                                             |  55        |
      Hyperplasia, Plasma Cell             | 3        3        3                                                      |      7  2.9|
      Sinus, Ectasia                       |          2     2                                                         |      9  2.1|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ectopic Tissue                       |          X                                                               |      2     |
      Fibrosis, Diffuse                    |                                                                          |      2  3.0|
      Fibrosis, Focal                      |                                                                          |      5  2.4|
      Fibrosis, Multifocal                 |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |       3                                                                  |      1  3.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Re Cell                 |                                                                          |      1  3.0|
      Necrosis, Focal                      | 3                                                                        |      1  3.0|
      Necrosis, Multifocal                 |             3                                                            |      1  3.0|
      Red Pulp, Atrophy                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  +  M  M                                             |  45        |
      Cyst                                 |                                                                          |      1     |
      Hemorrhage                           |                                                                          |      1  2.0|
      Epithelial Cell, Hyperplasia         | 1  2     2  2  1  2  2                                                   |     36  1.8|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  M  +  +  +  +  +  +                                             |  52        |
      Hyperplasia, Nodular                 |                                                                          |      1  2.0|
      Inflammation, Granulomatous          |             2                                                            |      1  2.0|
      Duct, Ectasia                        |             2                                                            |      4  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Ulcer                                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |                            2                                             |      2  2.0|
      Brain Stem, Compression              |                                                                          |      1  2.0|
      Cerebrum, Necrosis                   |                                                                          |      1  1.0|
      Medulla, Gliosis                     |                                                                          |      1  1.0|
      Thalamus, Necrosis                   |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | M  +  +  +  +  +  +  +  +  +                                             |  58        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  75                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 7| 7| 6| 6| 5|                                            |            |
                             DAY ON TEST   | 0| 3| 0| 8| 6| 3| 3| 9| 5| 2|                                            |            |
                                           | 2| 0| 8| 1| 0| 0| 0| 0| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |      A     |
    5 MG/KG                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |      L     |
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                            4                                             |      4  2.8|
      Hemorrhage                           |          4                                                               |      5  2.6|
      Infiltration Cellular, Histiocyte    | 1              1        1  1                                             |     15  1.1|
      Pigmentation                         | 1              1        1  1                                             |     15  1.1|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |       2  2                 2                                             |      7  2.0|
      Interstitium, Inflammation, Focal    |                                                                          |      1  1.0|
      Interstitium, Inflammation           |                                                                          |      1  2.0|
      Peribronchiolar, Foreign Body        |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fungus                               |                                                                          |      1  4.0|
      Hemorrhage                           |                                                                          |      2  2.5|
      Inflammation, Suppurative            |                                                                          |      3  2.7|
      Sinus, Inflammation, Chronic         |                                                                          |      1  2.0|
      Sinus, Inflammation, Chronic Active  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +  +                                                         |   4        |
      Cataract                             |                3                                                         |      3  2.7|
      Retina, Degeneration                 |             2  3                                                         |      4  2.8|
      Sclera, Metaplasia, Osseous          |             2                                                            |      2  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Pigmentation, Porphyrin              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      1     |
      Nephropathy                          | 2  3  2  2  2  2  3  2  3  2                                             |     57  2.2|
      Pigmentation                         |             4                                                            |      4  3.0|
      Pelvis, Epithelium, Hyperplasia,     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  76                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 7| 7| 6| 6| 5|                                            |            |
                             DAY ON TEST   | 0| 3| 0| 8| 6| 3| 3| 9| 5| 2|                                            |            |
                                           | 2| 0| 8| 1| 0| 0| 0| 0| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |      A     |
    5 MG/KG                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |      L     |
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Renal Tubule, Necrosis               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      3  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  77                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 5| 7| 7| 6| 5| 3| 7| 6| 6| 5| 2| 6| 6| 5| 4| 3| 7| 3| 3| 3| 3|             
                             DAY ON TEST   | 2| 7| 0| 5| 5| 2| 0| 6| 6| 4| 1| 4| 4| 6| 3| 7| 5| 7| 6| 3| 2| 4| 4| 3| 4|             
                                           | 9| 7| 7| 7| 7| 9| 1| 9| 3| 8| 9| 8| 5| 9| 5| 7| 0| 9| 6| 2| 9| 1| 1| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10MG/KG                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  A  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  A  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  M  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  A  +  A  +  A  +  +  +  A  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  +  A  +  A  +  +  +  A  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  A  +  A  +  +  +  A  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  A  +  A  +  +  +  A  +  A  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                2  2  2           2                                       |             
      Basophilic Focus, Focal              |                   2                                                      |             
      Basophilic Focus                     |          2                                                               |             
      Basophilic Focus, Multifocal         | 2                                                                        |             
      Congestion                           |                                                                3        3|             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Fatty Change, Focal                  |                      3                                                   |             
      Hepatodiaphragmatic Nodule           |                                              X  X                        |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Leukocytosis                         |                                                                          |             
      Bile Duct, Hyperplasia               | 2  2     2  2  2  2  2  2     3  2  2  2     2  2  2  1  2  2     2  2   |             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +           +                                                      |             
      Inflammation, Focal, Granulomatous   |                   4                                                      |             
      Artery, Inflammation, Chronic        |                                                                          |             
      Fat, Necrosis, Focal                 |       4                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 2  2        2  2           2     4     2     1  2  3                     |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                       2                  |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Chronic Active         |                                                                         2|             
      Ulcer                                |                            3                                            2|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 | 2  1     1  1  1  1  1  1           1     2           2     1     1      |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 5| 7| 7| 6| 5| 3| 7| 6| 6| 5| 2| 6| 6| 5| 4| 3| 7| 3| 3| 3| 3|             
                             DAY ON TEST   | 2| 7| 0| 5| 5| 2| 0| 6| 6| 4| 1| 4| 4| 6| 3| 7| 5| 7| 6| 3| 2| 4| 4| 3| 4|             
                                           | 9| 7| 7| 7| 7| 9| 1| 9| 3| 8| 9| 8| 5| 9| 5| 7| 0| 9| 6| 2| 9| 1| 1| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10MG/KG                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2        1  2  2  2  2  1        3  1  1  2     2  2        2           2|             
      Mineralization                       |                                                                          |             
      Artery, Myocardium, Degeneration     |                                                             1            |             
      Atrium, Dilatation                   |                                                                          |             
      Epicardium, Inflammation, Chronic    |                                                                          |             
          Active, Focal                    |                                                                          |             
      Myocardium, Inflammation, Chronic,   |                                                                          |             
           Focal                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |             X                                                            |             
      Hyperplasia, Focal                   |                      1  4                                                |             
      Hypertrophy                          |       2                                                                  |             
      Vacuolization Cytoplasmic, Focal     |    2                                1                       3            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +  +  +  +  +  +  M  +  +  +  +  +  M  +  M  +  +  +  +  M  +  I|             
      Hyperplasia, Focal                   |                         1     2                             1            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  M  M  +  M  +  +  +  +  +  +  M  M  +  +  M  +  +  M  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2                                                                        |             
      Cyst                                 |                                     X                                    |             
      Pars Distalis, Hyperplasia, Focal    | 2        1  2  2  2     2     2                             2     1      |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |    X                                   X                 X               |             
      C-Cell, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Spermatocele                         |                                     X                                    |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  M  M  +  M|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         | 2           1  2  2  2        2                                      2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 5| 7| 7| 6| 5| 3| 7| 6| 6| 5| 2| 6| 6| 5| 4| 3| 7| 3| 3| 3| 3|             
                             DAY ON TEST   | 2| 7| 0| 5| 5| 2| 0| 6| 6| 4| 1| 4| 4| 6| 3| 7| 5| 7| 6| 3| 2| 4| 4| 3| 4|             
                                           | 9| 7| 7| 7| 7| 9| 1| 9| 3| 8| 9| 8| 5| 9| 5| 7| 0| 9| 6| 2| 9| 1| 1| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10MG/KG                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Duct, Ectasia                        |                            2                                             |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |             3                                                            |             
      Inflammation, Suppurative            |                                                                          |             
      Epithelium, Hyperplasia, Focal       |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypospermia                          |                                     3                                    |             
      Interstitial Cell, Hyperplasia       |                                  2  2           2        2        2      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    3                       3                 2                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Lumbar, Hemorrhage                   |                                                                          |             
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |             
      Lumbar, Pigmentation, Hemosiderin    |                                                                          |             
      Mediastinal, Hemorrhage              |    2                                         2        2  3               |             
      Mediastinal, Hyperplasia, Re Cell    |                                                                          |             
      Mediastinal, Sinus, Ectasia          |                                                                          |             
      Mesenteric, Degeneration, Cystic     |                                                                          |             
      Mesenteric, Hemorrhage               |                                                                          |             
      Mesenteric, Inflammation,            |                                                                          |             
          Granulomatous                    |                                                                          |             
      Mesenteric, Sinus, Ectasia           |                                                                          |             
      Pancreatic, Hemorrhage               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +|             
      Congestion                           |                                                    3                     |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                             2            |             
      Sinus, Ectasia                       |             2                       2                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Necrosis, Focal                      |       3                                                                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  M  M  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                    3                     |             
      Hemorrhage                           |                   2     2  2              2                          2   |             
      Epithelial Cell, Hyperplasia         | 2     2     2  2  2  2  1     2  2        1        1  1  2  2     2     2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  M  +  +  M  +  +  +  +  M|             
      Duct, Ectasia                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 5| 7| 7| 6| 5| 3| 7| 6| 6| 5| 2| 6| 6| 5| 4| 3| 7| 3| 3| 3| 3|             
                             DAY ON TEST   | 2| 7| 0| 5| 5| 2| 0| 6| 6| 4| 1| 4| 4| 6| 3| 7| 5| 7| 6| 3| 2| 4| 4| 3| 4|             
                                           | 9| 7| 7| 7| 7| 9| 1| 9| 3| 8| 9| 8| 5| 9| 5| 7| 0| 9| 6| 2| 9| 1| 1| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10MG/KG                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fat, Necrosis                        |       3                                                                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |       4                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                                                          |             
      Cranium, Fibrous Osteodystrophy      |                                                                          |             
      Femur, Fibrous Osteodystrophy        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                         2                                                |             
      Hemorrhage                           |       2                    2                       2  2                  |             
      Cerebrum, Necrosis                   |    2  2  2           2  3                    3  2     2  1              2|             
      Meninges, Hyperplasia                |                         2                                                |             
      Pons, Necrosis                       |                                                    2                     |             
      Thalamus, Gliosis                    |                                                                          |             
      Thalamus, Necrosis                   |    2     2  1        2  2  3     1  3           3     3  3     3        3|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  M  M  +  +  +  M  M  +  +  M  M  M  +  M  M  M  M|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  +  +  +  +  M  M  +  +  +  M  M  +  +  M  M  M  +  M  M  M  M|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                   4     3        3  3  3  3              3  2  3  3  3  3|             
      Hemorrhage                           |    2              4     3           2                 2  2     2         |             
      Infiltration Cellular, Histiocyte    | 1           1                                1  1  1           1        1|             
      Necrosis, Focal                      |                                                                          |             
      Pigmentation                         |             1                                   1  1           1        1|             
      Pigmentation, Hemoglobin             |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                  2                                       |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Pleura, Fibrosis, Focal              |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                   3     4|             
      Hemorrhage                           |                                                                2         |             
      Inflammation, Suppurative            |                                                 1                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                                +                                 |             
      Cataract                             |       1                                                                  |             
      Retina, Degeneration                 |                                                                          |             
      Sclera, Metaplasia, Osseous          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 5| 7| 7| 6| 5| 3| 7| 6| 6| 5| 2| 6| 6| 5| 4| 3| 7| 3| 3| 3| 3|             
                             DAY ON TEST   | 2| 7| 0| 5| 5| 2| 0| 6| 6| 4| 1| 4| 4| 6| 3| 7| 5| 7| 6| 3| 2| 4| 4| 3| 4|             
                                           | 9| 7| 7| 7| 7| 9| 1| 9| 3| 8| 9| 8| 5| 9| 5| 7| 0| 9| 6| 2| 9| 1| 1| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10MG/KG                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                          3               |             
      Cyst                                 |                                                                          |             
      Nephropathy                          | 2  3  2  1  2  2  2  3  1  1  2  2  1  2     2  2  2  1     3           1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 5| 6| 5| 4| 4| 4| 6| 6| 6| 6| 5| 2| 7| 7| 6| 4| 7| 6| 6| 4| 4|             
                             DAY ON TEST   | 2| 6| 6| 4| 9| 7| 9| 1| 1| 1| 7| 6| 4| 1| 4| 2| 2| 2| 5| 7| 2| 4| 3| 3| 3|             
                                           | 9| 7| 7| 5| 1| 0| 6| 5| 5| 4| 7| 2| 9| 7| 3| 0| 9| 9| 9| 4| 9| 0| 7| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    10MG/KG                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  A  +  M  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  A  A  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  A  +  +  +  A  +  +  M  +  +  A  +  +  A  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  A  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  A  +  +  +  A  A  A  +  +  +  +  +  A  A  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2           2                 2  2     2                       2         |             
      Basophilic Focus, Focal              |                                     2              2                     |             
      Basophilic Focus                     |                                                                          |             
      Basophilic Focus, Multifocal         |                                  2                                       |             
      Congestion                           |                   3                                                      |             
      Cytoplasmic Alteration, Focal        |                                                    2                     |             
      Fatty Change, Focal                  |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                    X                     |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                            1                                             |             
      Leukocytosis                         |                                     1                                    |             
      Bile Duct, Hyperplasia               | 3  2  2  2  2  2  2  2  2  2  2  2  2  2  2     2  2  2  3  2  2  2  2  1|             
      Centrilobular, Necrosis              |                                        2                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +              +        +  +     +            |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Artery, Inflammation, Chronic        |                                           2                              |             
      Fat, Necrosis, Focal                 |                            4                          3     4            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 2        3  2     1           2  2                    2  3              2|             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                               2                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |    3                    4  3                                             |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 | 2  1     1     3  1  1           1  2  2  1     2  2  2     2  1         |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Inflammation, Chronic Active         |                         2                                                |             
      Mineralization                       |                4                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 5| 6| 5| 4| 4| 4| 6| 6| 6| 6| 5| 2| 7| 7| 6| 4| 7| 6| 6| 4| 4|             
                             DAY ON TEST   | 2| 6| 6| 4| 9| 7| 9| 1| 1| 1| 7| 6| 4| 1| 4| 2| 2| 2| 5| 7| 2| 4| 3| 3| 3|             
                                           | 9| 7| 7| 5| 1| 0| 6| 5| 5| 4| 7| 2| 9| 7| 3| 0| 9| 9| 9| 4| 9| 0| 7| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    10MG/KG                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  2     2  2  2           2     2     2     2  2  1     2     2      |             
      Mineralization                       |                2                                                         |             
      Artery, Myocardium, Degeneration     |                                                                          |             
      Atrium, Dilatation                   |          4                                                               |             
      Epicardium, Inflammation, Chronic    |                                                                          |             
          Active, Focal                    |                                                                          |             
      Myocardium, Inflammation, Chronic,   |                                                                          |             
           Focal                           |                                                                         1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Hyperplasia, Focal                   |                               2                                          |             
      Hypertrophy                          |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                2        2                                   2            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |       2  1  2                 2  1                 2     1               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  M  +  M  M  +  M  +  +  +  M  +  M  +  +  +  +|             
      Hyperplasia                          |                3                                                         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                    2           2         |             
      Pars Distalis, Hyperplasia           |                                                       3                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                               X                                          |             
      C-Cell, Hyperplasia                  |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                +                                                         |             
      Mineralization                       |                4                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Spermatocele                         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                           X                              |             
      Inflammation, Chronic Active         |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 5| 6| 5| 4| 4| 4| 6| 6| 6| 6| 5| 2| 7| 7| 6| 4| 7| 6| 6| 4| 4|             
                             DAY ON TEST   | 2| 6| 6| 4| 9| 7| 9| 1| 1| 1| 7| 6| 4| 1| 4| 2| 2| 2| 5| 7| 2| 4| 3| 3| 3|             
                                           | 9| 7| 7| 5| 1| 0| 6| 5| 5| 4| 7| 2| 9| 7| 3| 0| 9| 9| 9| 4| 9| 0| 7| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    10MG/KG                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                               2                    2                     |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                       4                  |             
      Epithelium, Hyperplasia, Focal       |                                           2     2                        |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypospermia                          |                                                                          |             
      Interstitial Cell, Hyperplasia       |    2  2  2  2        2  2  2                          2  2               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Lumbar, Hemorrhage                   |                2                                   1                     |             
      Lumbar, Hyperplasia, Plasma Cell     |                2                                                         |             
      Lumbar, Pigmentation, Hemosiderin    |                                                    2                     |             
      Mediastinal, Hemorrhage              |                   2                    2           2        2            |             
      Mediastinal, Hyperplasia, Re Cell    |                                                 2                        |             
      Mediastinal, Sinus, Ectasia          |                                        2                                 |             
      Mesenteric, Degeneration, Cystic     |                                                                          |             
      Mesenteric, Hemorrhage               |          2                             2                                 |             
      Mesenteric, Inflammation,            |                                                                          |             
          Granulomatous                    |                   1                                                      |             
      Mesenteric, Sinus, Ectasia           | 2              2                       2                                3|             
      Pancreatic, Hemorrhage               |                2                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                        4                                 |             
      Hyperplasia, Lymphoid                |                                                    2                     |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Sinus, Ectasia                       | 2              2                                                         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      | 3              3                                               2         |             
      Necrosis, Focal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  M  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Epithelial Cell, Hyperplasia         | 2        2  2  2  2  2  2     2     2  2        2  2  2  2  2  1  2     2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  M  M  +|             
      Duct, Ectasia                        |    3                                2                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 5| 6| 5| 4| 4| 4| 6| 6| 6| 6| 5| 2| 7| 7| 6| 4| 7| 6| 6| 4| 4|             
                             DAY ON TEST   | 2| 6| 6| 4| 9| 7| 9| 1| 1| 1| 7| 6| 4| 1| 4| 2| 2| 2| 5| 7| 2| 4| 3| 3| 3|             
                                           | 9| 7| 7| 5| 1| 0| 6| 5| 5| 4| 7| 2| 9| 7| 3| 0| 9| 9| 9| 4| 9| 0| 7| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    10MG/KG                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                +                                   +                     |             
      Cranium, Fibrous Osteodystrophy      |                X                                                         |             
      Femur, Fibrous Osteodystrophy        |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                      2                                                   |             
      Hemorrhage                           |             3                                         1                  |             
      Cerebrum, Necrosis                   |    1  3           2           2     2     4           3  2     3     3  4|             
      Meninges, Hyperplasia                |                                                                          |             
      Pons, Necrosis                       |                                                                          |             
      Thalamus, Gliosis                    |       3                                                                  |             
      Thalamus, Necrosis                   |       3  1  3     4     1  4  2  1        4           2              1  4|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        | +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |    3  2  3        3  4  3  4  2     3     3  4                 3  3     4|             
      Hemorrhage                           |             1                 2  1  2        3           1           2   |             
      Infiltration Cellular, Histiocyte    | 1        1        1           1  1     1           1  1     1        1   |             
      Necrosis, Focal                      |                                              2                           |             
      Pigmentation                         | 1        1        1           1  1     1           1  1     1        1   |             
      Pigmentation, Hemoglobin             |                1                                                         |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                         2                                   2            |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Pleura, Fibrosis, Focal              |                                                 2                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                   3                                                      |             
      Hemorrhage                           |                   1                          2                           |             
      Inflammation, Suppurative            |                   1                       2                              |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                          +               |             
      Cataract                             |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
      Sclera, Metaplasia, Osseous          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 5| 6| 5| 4| 4| 4| 6| 6| 6| 6| 5| 2| 7| 7| 6| 4| 7| 6| 6| 4| 4|             
                             DAY ON TEST   | 2| 6| 6| 4| 9| 7| 9| 1| 1| 1| 7| 6| 4| 1| 4| 2| 2| 2| 5| 7| 2| 4| 3| 3| 3|             
                                           | 9| 7| 7| 5| 1| 0| 6| 5| 5| 4| 7| 2| 9| 7| 3| 0| 9| 9| 9| 4| 9| 0| 7| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    10MG/KG                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                 X                        |             
      Nephropathy                          | 3  2  2  3  2  4  2     1  2  2  2  2  2  2     2  3  2  1  3  3  1  1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  87                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 5| 6| 6| 5| 5| 2|                                            |            |
                             DAY ON TEST   | 2| 2| 6| 5| 2| 8| 6| 6| 1| 3|                                            |            |
                                           | 9| 9| 2| 4| 6| 1| 2| 3| 2| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    10MG/KG                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  A  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  A  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  A  +  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  A  +  +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          | 2                          1                                             |     12  1.9|
      Basophilic Focus, Focal              |                2                                                         |      4  2.0|
      Basophilic Focus                     |                                                                          |      1  2.0|
      Basophilic Focus, Multifocal         |          2                                                               |      3  2.0|
      Congestion                           |                                                                          |      3  3.0|
      Cytoplasmic Alteration, Focal        |                                                                          |      1  2.0|
      Fatty Change, Focal                  |                                                                          |      1  3.0|
      Hepatodiaphragmatic Nodule           |          X                                                               |      4     |
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  1.0|
      Leukocytosis                         |          2                                                               |      2  1.5|
      Bile Duct, Hyperplasia               | 2  2  2  2  2  2  2  2  1                                                |     53  2.0|
      Centrilobular, Necrosis              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +                                                |   8        |
      Inflammation, Focal, Granulomatous   |                                                                          |      1  4.0|
      Artery, Inflammation, Chronic        |                                                                          |      1  2.0|
      Fat, Necrosis, Focal                 |                         4                                                |      5  3.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acinus, Atrophy                      |          3     3  2                                                      |     22  2.2|
      Artery, Inflammation, Chronic Active | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acinus, Atrophy                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Erosion                              | 3  2                                                                     |      3  2.3|
      Hyperplasia, Focal                   |    2                                                                     |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      5  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  88                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 5| 6| 6| 5| 5| 2|                                            |            |
                             DAY ON TEST   | 2| 2| 6| 5| 2| 8| 6| 6| 1| 3|                                            |            |
                                           | 9| 9| 2| 4| 6| 1| 2| 3| 2| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    10MG/KG                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Degeneration, Cystic                 | 2  1  1     1  1     1  1                                                |     35  1.4|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       | 3                                                                        |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       | 2  2     2        2  2  1  1                                             |     36  1.8|
      Mineralization                       |                                                                          |      1  2.0|
      Artery, Myocardium, Degeneration     |                                                                          |      1  1.0|
      Atrium, Dilatation                   |                                                                          |      1  4.0|
      Epicardium, Inflammation, Chronic    |                                                                          |            |
          Active, Focal                    |                   2                                                      |      1  2.0|
      Myocardium, Inflammation, Chronic,   |                                                                          |            |
           Focal                           |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1     |
      Hyperplasia, Focal                   |       2  3                                                               |      5  2.4|
      Hypertrophy                          |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |    1  1                                                                  |      8  1.8|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  53        |
      Hyperplasia, Focal                   |       1                                                                  |     11  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  M  +                                             |  43        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  2.0|
      Cyst                                 |                X                                                         |      2     |
      Pars Distalis, Hyperplasia, Focal    |          2                                                               |     12  1.8|
      Pars Distalis, Hyperplasia           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Ultimobranchial Cyst                 |                                                                          |      4     |
      C-Cell, Hyperplasia                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  89                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 5| 6| 6| 5| 5| 2|                                            |            |
                             DAY ON TEST   | 2| 2| 6| 5| 2| 8| 6| 6| 1| 3|                                            |            |
                                           | 9| 9| 2| 4| 6| 1| 2| 3| 2| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    10MG/KG                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Mineralization                       |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Spermatocele                         |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  55        |
      Cyst                                 |                                                                          |      1     |
      Inflammation, Chronic Active         | 2     2  3                                                               |     11  2.0|
      Inflammation, Suppurative            |                                                                          |      2  2.0|
      Duct, Ectasia                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Epithelium, Hyperplasia, Focal       |                      2                                                   |      3  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hypospermia                          |                                                                          |      1  3.0|
      Interstitial Cell, Hyperplasia       |    2        2              2                                             |     17  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Lumbar, Hemorrhage                   |                                                                          |      2  1.5|
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |      1  2.0|
      Lumbar, Pigmentation, Hemosiderin    |                                                                          |      1  2.0|
      Mediastinal, Hemorrhage              |    2  3     2     2     3                                                |     13  2.2|
      Mediastinal, Hyperplasia, Re Cell    |                                                                          |      1  2.0|
      Mediastinal, Sinus, Ectasia          |                                                                          |      1  2.0|
      Mesenteric, Degeneration, Cystic     |                         3                                                |      1  3.0|
      Mesenteric, Hemorrhage               |          3                                                               |      3  2.3|
      Mesenteric, Inflammation,            |                                                                          |            |
          Granulomatous                    |                                                                          |      1  1.0|
      Mesenteric, Sinus, Ectasia           |                3                                                         |      5  2.4|
      Pancreatic, Hemorrhage               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +                                             |  55        |
      Congestion                           |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  90                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 5| 6| 6| 5| 5| 2|                                            |            |
                             DAY ON TEST   | 2| 2| 6| 5| 2| 8| 6| 6| 1| 3|                                            |            |
                                           | 9| 9| 2| 4| 6| 1| 2| 3| 2| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    10MG/KG                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
      Sinus, Ectasia                       |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis, Focal                      | 3                                                                        |      4  2.8|
      Necrosis, Focal                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  M  M  +  +  +  +  +  +                                             |  49        |
      Congestion                           |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      5  2.0|
      Epithelial Cell, Hyperplasia         |    2        1  1  2  2  1                                                |     40  1.8|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  +  +  +  +  +  +                                             |  50        |
      Duct, Ectasia                        |                                                                          |      2  2.5|
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Abscess                              |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |   2        |
      Cranium, Fibrous Osteodystrophy      |                                                                          |      1     |
      Femur, Fibrous Osteodystrophy        |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      2  2.0|
      Hemorrhage                           |                                                                          |      6  2.0|
      Cerebrum, Necrosis                   |             2        3  1                                                |     24  2.3|
      Meninges, Hyperplasia                |                                                                          |      1  2.0|
      Pons, Necrosis                       |                                                                          |      1  2.0|
      Thalamus, Gliosis                    |                                                                          |      1  3.0|
      Thalamus, Necrosis                   |                                                                          |     25  2.4|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +  +  +  +  +  +  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +  +  +  +  +  +  +  +  +  +                                             |  47        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |       3     3           2  4                                             |     30  3.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  91                                                               
NTP Experiment-Test: 05026-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 17:43:14  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 5| 6| 6| 5| 5| 2|                                            |            |
                             DAY ON TEST   | 2| 2| 6| 5| 2| 8| 6| 6| 1| 3|                                            |            |
                                           | 9| 9| 2| 4| 6| 1| 2| 3| 2| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    10MG/KG                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |       2  2                 4                                             |     17  2.2|
      Infiltration Cellular, Histiocyte    |    1        1  1     1                                                   |     21  1.0|
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Pigmentation                         |    1        1  1     1                                                   |     19  1.0|
      Pigmentation, Hemoglobin             |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                      2                                                   |      4  2.0|
      Alveolar Epithelium, Hyperplasia     |                   2                                                      |      1  2.0|
      Pleura, Fibrosis, Focal              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      3  3.3|
      Hemorrhage                           |                            2                                             |      4  1.8|
      Inflammation, Suppurative            |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                   +                                                      |   4        |
      Cataract                             |                   4                                                      |      2  2.5|
      Retina, Degeneration                 |                   3                                                      |      1  3.0|
      Sclera, Metaplasia, Osseous          |                   2                                                      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      1  3.0|
      Cyst                                 |                                                                          |      1     |
      Nephropathy                          | 2  2  2  1  1  1  2  2  2  1                                             |     53  1.9|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Transitional Epithelium, Hyperplasia,|                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  92                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           

--multipart-boundary
Content-type: text/plain
Range: bytes 849954-849954/849954


--multipart-boundary--
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.