TR 389 Rat Pathology Tables
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
Facility: Microbiological Associates
Chemical CAS #: 26628228
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5|
DAY ON TEST | 9| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 9| 8| 4| 2| 3| 3| 3| 3| 6| 3| 3| 3| 0| 9|
| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 3| 0| 9| 9| 7| 7| 7| 7| 9| 7| 7| 7| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 G/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
VEHICLEF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
__________________________________________________________________________|
Intestine Large | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | A + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | A + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + A + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + A + + + + + + A + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | 2 |
Basophilic Focus, Multifocal | 2 2 2 2 2 2 2 4 2 |
Congestion | |
Fatty Change, Diffuse | 2 |
Fatty Change, Focal | 2 2 |
Fatty Change, Multifocal | 2 2 |
Hematopoietic Cell Proliferation | 1|
Hepatodiaphragmatic Nodule | |
Hyperplasia, Multifocal, Nodular | 3 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
Inflammation, Chronic Active, | |
Multifocal | 1 |
Inflammation, Granulomatous | 2 |
Inflammation, Granulomatous, | |
Multifocal | 1 2 2 1 1 1 2 1 |
Leukocytosis | 3 2 2 |
Necrosis, Focal | 2 |
Necrosis, Multifocal | 2 |
Bile Duct, Hyperplasia | 2 1 2 1 1 2 1 1 2 2 1 1 1 2 |
Centrilobular, Fatty Change | 2 |
Centrilobular, Necrosis | 2|
Hepatocyte, Periportal, Necrosis | |
Periportal, Fatty Change | |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Fat, Necrosis, Focal | 4 4 4 4 4 3 4 |
Fat, Necrosis, Multifocal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | |
Acinus, Atrophy | 1 1 2 1 |
Acinus, Cytoplasmic Alteration, | |
Multifocal | 2 |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5|
DAY ON TEST | 9| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 9| 8| 4| 2| 3| 3| 3| 3| 6| 3| 3| 3| 0| 9|
| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 3| 0| 9| 9| 7| 7| 7| 7| 9| 7| 7| 7| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 G/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
VEHICLEF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Inflammation, Chronic | 2 2 |
Ulcer | |
Epithelium, Hyperplasia, Focal | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 1 2 1 2 1 1 1 2 1 2 2 2 2 1 1|
Erosion | 1|
Hyperplasia, Focal | |
Inflammation, Chronic Active, Focal | 2 |
__________________________________________________________________________|
Tongue | + |
__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation, | |
Chronic Active | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 2 2 1 2 1 |
Aortic Valve, Inflammation, Subacute | |
Myocardium, Atrium Right, Necrosis | |
Myocardium, Ventricle, Necrosis | |
Pericardium, Inflammation, | |
Necrotizing | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Angiectasis | 2 3 1 |
Degeneration, Ballooning, Focal | 2 |
Hyperplasia, Focal | 2 2 2 1 |
Hyperplasia, Multifocal | |
Infiltration Cellular, Lymphocyte | |
Necrosis, Multifocal | |
Vacuolization Cytoplasmic, Focal | |
Vacuolization Cytoplasmic | 3 |
Vacuolization Cytoplasmic, Multifocal| 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + M + + + + + + + + + + + + + + + M + + + +|
Angiectasis | 2 |
Hyperplasia, Focal | 2 |
Hyperplasia, Multifocal | |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5|
DAY ON TEST | 9| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 9| 8| 4| 2| 3| 3| 3| 3| 6| 3| 3| 3| 0| 9|
| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 3| 0| 9| 9| 7| 7| 7| 7| 9| 7| 7| 7| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 G/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
VEHICLEF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Infiltration Cellular, Lymphocyte | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + M + + + + + + + + + + M M + + + M M M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 2 3 2 2 2 |
Cyst | X X|
Pigmentation, Hemosiderin | |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 |
Pars Distalis, Hyperplasia | 3 3 |
Pars Nervosa, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 2 2 1 |
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | |
Duct, Ectasia | 3 3|
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cervix, Cyst | X X X |
Cervix, Inflammation, Chronic Active | |
Cervix, Inflammation, Suppurative | |
Endometrium, Cyst | X |
Endometrium, Cyst, Multiple | X |
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | |
Mediastinal, Hemorrhage | 3 2 2 2 2 2 |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Inflammation, | |
Granulomatous | 2 |
Mediastinal, Pigmentation, | |
Hemosiderin | 2 2 2 |
Mediastinal, Sinus, Ectasia | |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5|
DAY ON TEST | 9| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 9| 8| 4| 2| 3| 3| 3| 3| 6| 3| 3| 3| 0| 9|
| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 3| 0| 9| 9| 7| 7| 7| 7| 9| 7| 7| 7| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 G/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
VEHICLEF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mesenteric, Hemorrhage | 2 |
Mesenteric, Sinus, Ectasia | 2 2 |
Pancreatic, Hemorrhage | 2 |
Pancreatic, Pigmentation, Hemosiderin| 2 2 |
Pancreatic, Sinus, Ectasia | 2 |
Renal, Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + + + + +|
Hemorrhage | |
Hyperplasia, Plasma Cell | |
Inflammation, Granulomatous | 2 |
Sinus, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | X |
Fibrosis, Focal | 2 |
Hematopoietic Cell Proliferation | 3 4|
Inflammation, Granulomatous | 4 |
Necrosis | 4 3 |
__________________________________________________________________________|
Thymus | + + + + + + M + M + M + M + + + M M + M + M + + +|
Congestion | |
Ectopic Tissue | |
Hemorrhage | 2 |
Epithelial Cell, Hyperplasia | 2 2 2 2 1 2 2 2 2 1 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | X X |
Hyperplasia, Multifocal, Nodular | 2 |
Inflammation, Chronic Active | 4 |
Duct, Ectasia | 2 4 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + M + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Necrosis, Focal | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 6| 6| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5|
DAY ON TEST | 9| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 9| 8| 4| 2| 3| 3| 3| 3| 6| 3| 3| 3| 0| 9|
| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 3| 0| 9| 9| 7| 7| 7| 7| 9| 7| 7| 7| 3| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0 G/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|
VEHICLEF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Congestion | 3 |
Hemorrhage | 1 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Granulomatous, | |
Multifocal | 1 |
Leukocytosis | 3 |
Necrosis, Multifocal | |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Alveolar Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation | |
Inflammation, Suppurative | 2 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Artery, Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | |
Necrosis | |
Anterior Chamber, Inflammation, | |
Suppurative | 3 |
Retina, Degeneration | |
Sclera, Metaplasia, Osseous | |
__________________________________________________________________________|
Harderian Gland | + |
Infiltration Cellular, Lymphocyte | 2 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Concretion | 2 |
Cyst | |
Hydronephrosis | 2 |
Nephropathy | 1 2 2 2 1 1 2 2 2 2 1 2 2 1 2 1 2 3 2 2 2 1 1 |
Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Subacute | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 5| 3| 3| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 4| 3|
DAY ON TEST | 3| 3| 7| 1| 0| 3| 3| 3| 1| 4| 3| 3| 7| 3| 0| 3| 3| 3| 7| 8| 3| 3| 3| 5| 5|
| 3| 7| 8| 6| 6| 7| 7| 7| 9| 3| 7| 7| 1| 7| 5| 7| 7| 7| 5| 8| 7| 7| 7| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 G/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
VEHICLEF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 1 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + M M + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Colon | A + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | A + + + M + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + M + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + M M + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + M M M + + + + + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 2 |
Basophilic Focus | 1 |
Basophilic Focus, Multifocal | 2 2 2 2 2 2 2 2 |
Congestion | 3 |
Fatty Change, Diffuse | |
Fatty Change, Focal | 2 |
Fatty Change, Multifocal | 2 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | |
Hyperplasia, Multifocal, Nodular | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | 1 |
Inflammation, Chronic Active, | |
Multifocal | |
Inflammation, Granulomatous | 2 |
Inflammation, Granulomatous, | |
Multifocal | 1 1 2 1 1 1 1 1 1 1 1 1 |
Leukocytosis | |
Necrosis, Focal | |
Necrosis, Multifocal | 2 2 |
Bile Duct, Hyperplasia | 2 1 1 1 2 1 1 2 2 2 2 2 2 2 |
Centrilobular, Fatty Change | |
Centrilobular, Necrosis | |
Hepatocyte, Periportal, Necrosis | 1 |
Periportal, Fatty Change | 2 |
__________________________________________________________________________|
Mesentery | + + + + + + + + + |
Fat, Necrosis, Focal | 4 4 4 4 4 3 4 4 |
Fat, Necrosis, Multifocal | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | |
Acinus, Atrophy | 2 1 1 3 2 1 2 4 |
Acinus, Cytoplasmic Alteration, | |
Multifocal | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 5| 3| 3| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 4| 3|
DAY ON TEST | 3| 3| 7| 1| 0| 3| 3| 3| 1| 4| 3| 3| 7| 3| 0| 3| 3| 3| 7| 8| 3| 3| 3| 5| 5|
| 3| 7| 8| 6| 6| 7| 7| 7| 9| 3| 7| 7| 1| 7| 5| 7| 7| 7| 5| 8| 7| 7| 7| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 G/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
VEHICLEF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Salivary Glands | + + + + M + + + + + + + + + + + + + + + + + + + +|
Inflammation, Necrotizing | 4 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Inflammation, Chronic | |
Ulcer | 3 |
Epithelium, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 1 1 1 1 2 2 1 1 1 2 1 1|
Erosion | |
Hyperplasia, Focal | 2 |
Inflammation, Chronic Active, Focal | |
__________________________________________________________________________|
Tongue | |
__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 1 1 1 1 1 2 |
Aortic Valve, Inflammation, Subacute | 1 |
Myocardium, Atrium Right, Necrosis | |
Myocardium, Ventricle, Necrosis | |
Pericardium, Inflammation, | |
Necrotizing | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Angiectasis | 2 2 2 |
Degeneration, Ballooning, Focal | |
Hyperplasia, Focal | 2 2 2 2 2 |
Hyperplasia, Multifocal | 2 |
Infiltration Cellular, Lymphocyte | 1 |
Necrosis, Multifocal | 3 |
Vacuolization Cytoplasmic, Focal | 2 2 2 |
Vacuolization Cytoplasmic | |
Vacuolization Cytoplasmic, Multifocal| 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Focal | 2 2 |
Hyperplasia, Multifocal | |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 5| 3| 3| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 4| 3|
DAY ON TEST | 3| 3| 7| 1| 0| 3| 3| 3| 1| 4| 3| 3| 7| 3| 0| 3| 3| 3| 7| 8| 3| 3| 3| 5| 5|
| 3| 7| 8| 6| 6| 7| 7| 7| 9| 3| 7| 7| 1| 7| 5| 7| 7| 7| 5| 8| 7| 7| 7| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 G/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
VEHICLEF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Infiltration Cellular, Lymphocyte | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M M M + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Cyst | X X X X |
Pigmentation, Hemosiderin | 2 |
Pars Distalis, Hyperplasia, Focal | |
Pars Distalis, Hyperplasia | 3 |
Pars Nervosa, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 1 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + M + + + + + + + M + M + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | 4 |
Duct, Ectasia | 2 4 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cervix, Cyst | X X X X |
Cervix, Inflammation, Chronic Active | 4 |
Cervix, Inflammation, Suppurative | |
Endometrium, Cyst | X |
Endometrium, Cyst, Multiple | |
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + M + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Congestion | 4 |
Mediastinal, Hemorrhage | 1 2 2 2 2 3 |
Mediastinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Inflammation, | |
Granulomatous | 2 |
Mediastinal, Pigmentation, | |
Hemosiderin | 2 1 2 2 2 1 |
Mediastinal, Sinus, Ectasia | 2 |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 5| 3| 3| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 4| 3|
DAY ON TEST | 3| 3| 7| 1| 0| 3| 3| 3| 1| 4| 3| 3| 7| 3| 0| 3| 3| 3| 7| 8| 3| 3| 3| 5| 5|
| 3| 7| 8| 6| 6| 7| 7| 7| 9| 3| 7| 7| 1| 7| 5| 7| 7| 7| 5| 8| 7| 7| 7| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 G/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
VEHICLEF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mesenteric, Hemorrhage | 2 |
Mesenteric, Sinus, Ectasia | 2 2 2 2 |
Pancreatic, Hemorrhage | |
Pancreatic, Pigmentation, Hemosiderin| 2 |
Pancreatic, Sinus, Ectasia | |
Renal, Pigmentation, Hemosiderin | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + M M + + + + M + M + + + + I + + + + M + + +|
Hemorrhage | 2 |
Hyperplasia, Plasma Cell | 2 3 |
Inflammation, Granulomatous | |
Sinus, Ectasia | 2 2 1 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | |
Fibrosis, Focal | 4 |
Hematopoietic Cell Proliferation | 2 |
Inflammation, Granulomatous | 4 |
Necrosis | |
__________________________________________________________________________|
Thymus | + + M + + M M + M + + + + + + + + + + M + M + + +|
Congestion | 3 |
Ectopic Tissue | X |
Hemorrhage | 2 3 |
Epithelial Cell, Hyperplasia | 2 2 2 2 2 2 1 2 2 2 2 2 2 2 1 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + M + + + + + + + M + + + + + + + + + + + + + + +|
Galactocele | |
Hyperplasia, Multifocal, Nodular | |
Inflammation, Chronic Active | |
Duct, Ectasia | 2 3 4 3 4 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + M + + + + + + + + + + + + + M|
Hemorrhage | |
Necrosis, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 5| 3| 3| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 4| 3|
DAY ON TEST | 3| 3| 7| 1| 0| 3| 3| 3| 1| 4| 3| 3| 7| 3| 0| 3| 3| 3| 7| 8| 3| 3| 3| 5| 5|
| 3| 7| 8| 6| 6| 7| 7| 7| 9| 3| 7| 7| 1| 7| 5| 7| 7| 7| 5| 8| 7| 7| 7| 7| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 G/KG | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|
VEHICLEF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Congestion | 3 3 3 3 |
Hemorrhage | 2 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Granulomatous, | |
Multifocal | |
Leukocytosis | |
Necrosis, Multifocal | 4 |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 1 |
Inflammation | |
Inflammation, Suppurative | 1 2 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | |
Artery, Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + A |
Cataract | 3 |
Necrosis | 4 |
Anterior Chamber, Inflammation, | |
Suppurative | |
Retina, Degeneration | 3 |
Sclera, Metaplasia, Osseous | 2 |
__________________________________________________________________________|
Harderian Gland | + |
Infiltration Cellular, Lymphocyte | 1 |
__________________________________________________________________________|
Zymbal's Gland | +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Concretion | |
Cyst | |
Hydronephrosis | |
Nephropathy | 2 1 1 2 1 2 2 2 2 2 2 3 2 3 2 1 2 1 1 2 1|
Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Inflammation, Subacute | 2 |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| | |
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 9| 8| | |
| 7| 7| 7| 7| 4| 7| 7| 7| 9| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0 G/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
VEHICLEF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
Inflammation, Subacute | | 1 1.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + A + | 50 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 3 2.3|
Basophilic Focus | 2 2 | 4 1.8|
Basophilic Focus, Multifocal | 2 2 | 19 2.1|
Congestion | | 1 3.0|
Fatty Change, Diffuse | 2 | 2 2.0|
Fatty Change, Focal | | 3 2.0|
Fatty Change, Multifocal | 2 | 4 2.0|
Hematopoietic Cell Proliferation | | 1 1.0|
Hepatodiaphragmatic Nodule | X | 1 |
Hyperplasia, Multifocal, Nodular | | 1 3.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 1.0|
Inflammation, Chronic Active, | | |
Multifocal | | 1 1.0|
Inflammation, Granulomatous | | 2 2.0|
Inflammation, Granulomatous, | | |
Multifocal | 1 1 1 1 | 24 1.2|
Leukocytosis | 2 | 4 2.3|
Necrosis, Focal | | 1 2.0|
Necrosis, Multifocal | 1 | 4 1.8|
Bile Duct, Hyperplasia | 2 2 2 2 2 3 | 34 1.6|
Centrilobular, Fatty Change | | 1 2.0|
Centrilobular, Necrosis | 3 | 2 2.5|
Hepatocyte, Periportal, Necrosis | | 1 1.0|
Periportal, Fatty Change | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | | 16 |
Fat, Necrosis, Focal | | 15 3.9|
Fat, Necrosis, Multifocal | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| | |
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 9| 8| | |
| 7| 7| 7| 7| 4| 7| 7| 7| 9| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0 G/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
VEHICLEF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Ectopic Tissue | X | 1 |
Acinus, Atrophy | 2 4 3 2 | 16 2.0|
Acinus, Cytoplasmic Alteration, | | |
Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
Inflammation, Necrotizing | | 1 4.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Hyperplasia, Focal | | 1 2.0|
Inflammation, Chronic | | 2 2.0|
Ulcer | | 1 3.0|
Epithelium, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Degeneration, Cystic | 1 1 1 1 2 2 1 1 | 39 1.3|
Erosion | | 1 1.0|
Hyperplasia, Focal | | 1 2.0|
Inflammation, Chronic Active, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
__________________________________________________________________________|____________|
Tooth | | 1 |
Peridontal Tissue, Inflammation, | | |
Chronic Active | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 2 1 2 1 | 20 1.6|
Aortic Valve, Inflammation, Subacute | | 1 1.0|
Myocardium, Atrium Right, Necrosis | 3 | 1 3.0|
Myocardium, Ventricle, Necrosis | 2 | 1 2.0|
Pericardium, Inflammation, | | |
Necrotizing | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | | 1 |
Angiectasis | | 6 2.0|
Degeneration, Ballooning, Focal | | 1 2.0|
Hyperplasia, Focal | 2 2 2 | 12 1.9|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| | |
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 9| 8| | |
| 7| 7| 7| 7| 4| 7| 7| 7| 9| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0 G/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
VEHICLEF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia, Multifocal | | 1 2.0|
Infiltration Cellular, Lymphocyte | | 1 1.0|
Necrosis, Multifocal | 3 | 2 3.0|
Vacuolization Cytoplasmic, Focal | 2 2 2 | 6 2.0|
Vacuolization Cytoplasmic | | 1 3.0|
Vacuolization Cytoplasmic, Multifocal| | 2 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 58 |
Angiectasis | | 1 2.0|
Hyperplasia, Focal | | 3 2.0|
Hyperplasia, Multifocal | 2 3 | 2 2.5|
Infiltration Cellular, Lymphocyte | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Angiectasis | 3 3 | 10 2.5|
Cyst | X X X | 9 |
Pigmentation, Hemosiderin | 2 | 2 2.0|
Pars Distalis, Hyperplasia, Focal | 2 | 5 2.0|
Pars Distalis, Hyperplasia | | 3 3.0|
Pars Nervosa, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
C-Cell, Hyperplasia | | 8 1.6|
Follicle, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Hemorrhage | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + M + + + + M + | 55 |
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 2 3.0|
Duct, Ectasia | | 5 2.8|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Cyst | X | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Cervix, Cyst | X X | 9 |
Cervix, Inflammation, Chronic Active | 3 | 2 3.5|
Cervix, Inflammation, Suppurative | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| | |
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 9| 8| | |
| 7| 7| 7| 7| 4| 7| 7| 7| 9| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0 G/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
VEHICLEF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Endometrium, Cyst | | 2 |
Endometrium, Cyst, Multiple | | 1 |
Endometrium, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 59 |
Mediastinal, Congestion | | 1 4.0|
Mediastinal, Hemorrhage | 2 | 13 2.1|
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Inflammation, | | |
Granulomatous | | 2 2.0|
Mediastinal, Pigmentation, | | |
Hemosiderin | | 9 1.8|
Mediastinal, Sinus, Ectasia | | 1 2.0|
Mesenteric, Hemorrhage | 2 | 3 2.0|
Mesenteric, Sinus, Ectasia | 2 | 7 2.0|
Pancreatic, Hemorrhage | 2 3 | 3 2.3|
Pancreatic, Pigmentation, Hemosiderin| | 3 2.0|
Pancreatic, Sinus, Ectasia | 3 | 2 2.5|
Renal, Pigmentation, Hemosiderin | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M M + + + + + + | 51 |
Hemorrhage | | 1 2.0|
Hyperplasia, Plasma Cell | 2 3 | 4 2.5|
Inflammation, Granulomatous | | 1 2.0|
Sinus, Ectasia | 2 | 4 1.8|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Ectopic Tissue | X | 2 |
Fibrosis, Focal | 3 | 3 3.0|
Hematopoietic Cell Proliferation | | 3 3.0|
Inflammation, Granulomatous | | 2 4.0|
Necrosis | | 2 3.5|
__________________________________________________________________________|____________|
Thymus | M M M + + + + M + + | 42 |
Congestion | | 1 3.0|
Ectopic Tissue | | 1 |
Hemorrhage | 3 | 4 2.5|
Epithelial Cell, Hyperplasia | 2 2 2 2 2 2 | 38 1.9|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| | |
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 9| 8| | |
| 7| 7| 7| 7| 4| 7| 7| 7| 9| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0 G/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
VEHICLEF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 58 |
Galactocele | | 2 |
Hyperplasia, Multifocal, Nodular | | 1 2.0|
Inflammation, Chronic Active | | 1 4.0|
Duct, Ectasia | 2 | 9 3.1|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
Cyst Epithelial Inclusion | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + | 58 |
Hemorrhage | | 1 3.0|
Necrosis, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | 3 | 6 3.0|
Hemorrhage | 2 | 5 1.8|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 | 49 1.0|
Inflammation, Granulomatous, | | |
Multifocal | | 1 1.0|
Leukocytosis | | 1 3.0|
Necrosis, Multifocal | | 1 4.0|
Pigmentation | 1 1 1 1 1 1 1 | 49 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 | 3 2.3|
Alveolar Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Foreign Body | | 1 1.0|
Inflammation | 2 | 1 2.0|
Inflammation, Suppurative | | 5 1.6|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
Inflammation, Suppurative | 3 | 1 3.0|
Artery, Inflammation, Chronic Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| | |
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 9| 8| | |
| 7| 7| 7| 7| 4| 7| 7| 7| 9| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0 G/KG | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| | L |
VEHICLEF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Eye | | 4 |
Cataract | | 1 3.0|
Necrosis | | 1 4.0|
Anterior Chamber, Inflammation, | | |
Suppurative | | 1 3.0|
Retina, Degeneration | | 1 3.0|
Sclera, Metaplasia, Osseous | | 1 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 2 |
Infiltration Cellular, Lymphocyte | | 2 1.5|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Concretion | | 1 2.0|
Cyst | X | 1 |
Hydronephrosis | | 1 2.0|
Nephropathy | 2 2 2 2 2 1 2 2 2 2 | 54 1.8|
Pigmentation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Serosa, Inflammation, Subacute | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 2| 0| 3| 3| 2| 4| 5| 3| 3| 3| 3| 0| 3| 3| 2| 3| 0| 3| 3| 3| 3| 3|
| 8| 0| 0| 2| 3| 0| 0| 8| 8| 3| 0| 0| 0| 0| 4| 0| 0| 1| 0| 5| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
5 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
LOW FEMA | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Small | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + A A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus, Multifocal | 2 2 2 2 2 2 2 2 2 2 |
Eosinophilic Focus | 4 |
Fatty Change, Diffuse | 3 |
Fatty Change, Multifocal | |
Hepatodiaphragmatic Nodule | X X X|
Inflammation, Acute, Multifocal | |
Inflammation, Chronic Active, Focal | |
Inflammation, Granulomatous, | |
Multifocal | 1 2 1 1 1 1 1 1 1 1 |
Leukocytosis | |
Mixed Cell Focus | |
Bile Duct, Hyperplasia | 2 2 2 2 1 2 2 1 2 2 2 1|
Centrilobular, Fatty Change | 2 |
Centrilobular, Necrosis, Coagulative | |
Centrilobular, Necrosis | 2 |
Periportal, Fatty Change | 2 |
__________________________________________________________________________|
Mesentery | + + + + + |
Fat, Necrosis, Focal | 4 4 4 |
Fat, Necrosis, Multifocal | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 2 3 3 2 |
Acinus, Hyperplasia, Focal | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + M + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 3 2 1 3 1 1 1 2 1 1 2 1 2 1 1 2 2 1 1 2 1 2|
Infiltration Cellular, Focal, | |
Lymphocyte | |
Lamina Propria, Fibrosis, Focal | |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 2| 0| 3| 3| 2| 4| 5| 3| 3| 3| 3| 0| 3| 3| 2| 3| 0| 3| 3| 3| 3| 3|
| 8| 0| 0| 2| 3| 0| 0| 8| 8| 3| 0| 0| 0| 0| 4| 0| 0| 1| 0| 5| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
5 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
LOW FEMA | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 2 2 2 1 2 2|
Aortic Valve, Inflammation, Chronic | |
Active | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Angiectasis | 2 3 |
Hyperplasia, Focal | |
Hyperplasia, Multifocal | |
Necrosis, Focal | 3 |
Vacuolization Cytoplasmic, Diffuse | 3 |
Vacuolization Cytoplasmic, Focal | 2 |
Vacuolization Cytoplasmic, Multifocal| 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | M + + + + + + + + + + + M + + + + + + M + + + + +|
Hyperplasia, Focal | 2 |
Hyperplasia, Multifocal | 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Cyst | X X X X X X X X X |
Pigmentation, Hemosiderin | 2 2 |
Pars Distalis, Hyperplasia, Focal | |
Pars Distalis, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 3 |
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + M + + + + + + + M + + + M + + + + +|
Inflammation, Chronic Active | 2 |
Duct, Ectasia | 2 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 2| 0| 3| 3| 2| 4| 5| 3| 3| 3| 3| 0| 3| 3| 2| 3| 0| 3| 3| 3| 3| 3|
| 8| 0| 0| 2| 3| 0| 0| 8| 8| 3| 0| 0| 0| 0| 4| 0| 0| 1| 0| 5| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
5 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
LOW FEMA | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | |
Inflammation, Chronic Active | |
Cervix, Cyst | X X X X |
Cervix, Hypertrophy | |
Cervix, Inflammation, Suppurative | |
Endometrium, Cyst | X |
Endometrium, Hyperplasia, Cystic | 3 |
Endometrium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + M + +|
Hemorrhage | |
Mediastinal, Hemorrhage | 2 2 2|
Mediastinal, Hyperplasia, Reticulum | |
Cell | |
Mediastinal, Pigmentation, | |
Hemosiderin | 2 2 2 2|
Mediastinal, Sinus, Ectasia | |
Mesenteric, Hemorrhage | |
Mesenteric, Pigmentation, Hemosiderin| 2 |
Mesenteric, Sinus, Ectasia | 2 2 2 2 2 2 2 2 |
Pancreatic, Hemorrhage | 2 2 |
Pancreatic, Pigmentation, Hemosiderin| 2 2 |
Pancreatic, Sinus, Ectasia | 2 |
Renal, Infiltration Cellular, | |
Histiocyte | 3 |
Renal, Pigmentation, Hemosiderin | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M + + M M + + + + + + + + + + + + + + M M + M|
Hyperplasia, Plasma Cell | 2 2 |
Sinus, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | |
Fibrosis, Focal | 3 |
Hematopoietic Cell Proliferation | 4 |
Red Pulp, Atrophy | 3 |
__________________________________________________________________________|
Thymus | M + + + + + + + M + + M M + M + + + + + + + + + +|
Congestion | 3 |
Cyst | X |
Ectopic Tissue | X |
Hemorrhage | |
Epithelial Cell, Hyperplasia | 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 2| 0| 3| 3| 2| 4| 5| 3| 3| 3| 3| 0| 3| 3| 2| 3| 0| 3| 3| 3| 3| 3|
| 8| 0| 0| 2| 3| 0| 0| 8| 8| 3| 0| 0| 0| 0| 4| 0| 0| 1| 0| 5| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
5 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
LOW FEMA | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + M + + + + + + + M + + + + + M + M + + + + +|
Duct, Ectasia | 3 3 3 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + |
Femur, Osteopetrosis | 3 |
Vertebra, Osteopetrosis | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Gliosis | 2 |
Cerebrum, Necrosis | 2 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 3 2 |
Fungus | |
Hemorrhage | 1 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Inflammation, Focal, Granulomatous | |
Pigmentation, Diffuse, Hemosiderin | 3 |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Alveolar Epithelium, Hyperplasia, | |
Multifocal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Middle Ear, Inflammation, Suppurative| |
__________________________________________________________________________|
Eye | + + |
Cataract | 3 |
Necrosis | 4 |
Retina, Degeneration | |
Sclera, Metaplasia, Osseous | |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 2| 0| 3| 3| 2| 4| 5| 3| 3| 3| 3| 0| 3| 3| 2| 3| 0| 3| 3| 3| 3| 3|
| 8| 0| 0| 2| 3| 0| 0| 8| 8| 3| 0| 0| 0| 0| 4| 0| 0| 1| 0| 5| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
5 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
LOW FEMA | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Harderian Gland | |
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 1 2 1 2 2 2 1 2 2 1 1 1 1 2 1 1 3 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + M + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Serosa, Inflammation, Chronic | |
Transitional Epithelium, Hyperplasia,| |
Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 4| 3| 3| 3| 7| 2| 3| 3| 3| 9| 8|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 9| 0| 0| 0| 0| 0| 8| 0| 0| 0| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
5 MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
LOW FEMA | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 4 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 |
Eosinophilic Focus | |
Fatty Change, Diffuse | 2 |
Fatty Change, Multifocal | 2 |
Hepatodiaphragmatic Nodule | X X X X |
Inflammation, Acute, Multifocal | 1 |
Inflammation, Chronic Active, Focal | 2|
Inflammation, Granulomatous, | |
Multifocal | 1 1 2 1 |
Leukocytosis | 1 |
Mixed Cell Focus | 2 |
Bile Duct, Hyperplasia | 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 3 2 2 2 1|
Centrilobular, Fatty Change | 2 |
Centrilobular, Necrosis, Coagulative | |
Centrilobular, Necrosis | |
Periportal, Fatty Change | 2 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis, Focal | 4 4 |
Fat, Necrosis, Multifocal | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 1 2 1 1 |
Acinus, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + M + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 2 2 2 1 2 2 1 2 2 2 2 1 2 2 2 1 2 2 2 2 1 2|
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Lamina Propria, Fibrosis, Focal | 2|
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 4| 3| 3| 3| 7| 2| 3| 3| 3| 9| 8|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 9| 0| 0| 0| 0| 0| 8| 0| 0| 0| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
5 MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
LOW FEMA | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 2 1 2 2 2 2 |
Aortic Valve, Inflammation, Chronic | |
Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Angiectasis | |
Hyperplasia, Focal | 2 2 2 |
Hyperplasia, Multifocal | 2 |
Necrosis, Focal | |
Vacuolization Cytoplasmic, Diffuse | 2 |
Vacuolization Cytoplasmic, Focal | 2 2 2 2 |
Vacuolization Cytoplasmic, Multifocal| |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + M + + + + M + + + + + M|
Hyperplasia, Focal | |
Hyperplasia, Multifocal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Parathyroid Gland | + M + + + + M + M + M + M + + + + + + + M + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 3 2 |
Cyst | X X X X |
Pigmentation, Hemosiderin | |
Pars Distalis, Hyperplasia, Focal | 2 2 |
Pars Distalis, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | |
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Duct, Ectasia | 3 3 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
Page 24
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 4| 3| 3| 3| 7| 2| 3| 3| 3| 9| 8|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 9| 0| 0| 0| 0| 0| 8| 0| 0| 0| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
5 MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
LOW FEMA | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrometra | 3 3 |
Inflammation, Chronic Active | 3 |
Cervix, Cyst | X X X X X X |
Cervix, Hypertrophy | 3 |
Cervix, Inflammation, Suppurative | 3 3 |
Endometrium, Cyst | |
Endometrium, Hyperplasia, Cystic | 4 2 |
Endometrium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Mediastinal, Hemorrhage | 3 2 2 2 |
Mediastinal, Hyperplasia, Reticulum | |
Cell | 2 |
Mediastinal, Pigmentation, | |
Hemosiderin | 2 2 2 |
Mediastinal, Sinus, Ectasia | 2 |
Mesenteric, Hemorrhage | 2 |
Mesenteric, Pigmentation, Hemosiderin| |
Mesenteric, Sinus, Ectasia | 2 2 2 2 |
Pancreatic, Hemorrhage | |
Pancreatic, Pigmentation, Hemosiderin| 3 2|
Pancreatic, Sinus, Ectasia | |
Renal, Infiltration Cellular, | |
Histiocyte | |
Renal, Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia, Plasma Cell | 3 3 2 3|
Sinus, Ectasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | X X |
Fibrosis, Focal | 3 3 2 |
Hematopoietic Cell Proliferation | |
Red Pulp, Atrophy | |
__________________________________________________________________________|
Thymus | + + + + + + + M + M + + + + + + + + M + + + + + +|
Congestion | |
Cyst | |
Ectopic Tissue | |
Hemorrhage | 2 |
Epithelial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 25
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 4| 3| 3| 3| 7| 2| 3| 3| 3| 9| 8|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 9| 0| 0| 0| 0| 0| 8| 0| 0| 0| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
5 MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
LOW FEMA | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Duct, Ectasia | 3 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + |
Femur, Osteopetrosis | |
Vertebra, Osteopetrosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Gliosis | |
Cerebrum, Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | I + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fungus | X |
Hemorrhage | 1 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Inflammation, Focal, Granulomatous | 3 |
Pigmentation, Diffuse, Hemosiderin | |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2|
Alveolar Epithelium, Hyperplasia, | |
Multifocal | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Middle Ear, Inflammation, Suppurative| |
__________________________________________________________________________|
Eye | + + + |
Cataract | 3 |
Necrosis | 4 |
Retina, Degeneration | 3 |
Sclera, Metaplasia, Osseous | 2 |
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 4| 3| 3| 3| 7| 2| 3| 3| 3| 9| 8|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 9| 0| 0| 0| 0| 0| 8| 0| 0| 0| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
5 MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
LOW FEMA | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
__________________________________________________________________________|
Harderian Gland | + |
Infiltration Cellular, Lymphocyte | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy | 2 3 2 2 2 1 1 1 2 2 1 2 1 2 1 2 2 1 2 1 2 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + M + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 1 |
Serosa, Inflammation, Chronic | 3 |
Transitional Epithelium, Hyperplasia,| |
Focal | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| | |
DAY ON TEST | 3| 3| 3| 3| 4| 3| 3| 3| 3| 0| | |
| 0| 0| 0| 0| 9| 0| 0| 0| 0| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
5 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
LOW FEMA | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M + + + + + + + + + | 59 |
Ulcer | | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Basophilic Focus, Multifocal | 2 2 2 2 2 | 26 2.0|
Eosinophilic Focus | | 1 4.0|
Fatty Change, Diffuse | | 2 2.5|
Fatty Change, Multifocal | | 1 2.0|
Hepatodiaphragmatic Nodule | X | 8 |
Inflammation, Acute, Multifocal | | 1 1.0|
Inflammation, Chronic Active, Focal | | 1 2.0|
Inflammation, Granulomatous, | | |
Multifocal | 1 1 | 16 1.1|
Leukocytosis | | 1 1.0|
Mixed Cell Focus | | 1 2.0|
Bile Duct, Hyperplasia | 2 1 2 2 2 | 37 1.9|
Centrilobular, Fatty Change | | 2 2.0|
Centrilobular, Necrosis, Coagulative | 2 2 | 2 2.0|
Centrilobular, Necrosis | | 1 2.0|
Periportal, Fatty Change | 3 | 3 2.3|
__________________________________________________________________________|____________|
Mesentery | + + | 10 |
Fat, Necrosis, Focal | 4 4 | 7 4.0|
Fat, Necrosis, Multifocal | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Acinus, Atrophy | 1 2 | 13 1.8|
Acinus, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 57 |
Ulcer | 3 | 2 2.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| | |
DAY ON TEST | 3| 3| 3| 3| 4| 3| 3| 3| 3| 0| | |
| 0| 0| 0| 0| 9| 0| 0| 0| 0| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
5 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
LOW FEMA | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Degeneration, Cystic | 2 1 2 1 2 2 1 2 1 | 56 1.6|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 2.0|
Lamina Propria, Fibrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 1 2 1 2 | 21 1.7|
Aortic Valve, Inflammation, Chronic | | |
Active | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | X | 1 |
Angiectasis | | 2 2.5|
Hyperplasia, Focal | | 3 2.0|
Hyperplasia, Multifocal | | 1 2.0|
Necrosis, Focal | | 1 3.0|
Vacuolization Cytoplasmic, Diffuse | | 2 2.5|
Vacuolization Cytoplasmic, Focal | 2 | 6 2.0|
Vacuolization Cytoplasmic, Multifocal| | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 54 |
Hyperplasia, Focal | | 1 2.0|
Hyperplasia, Multifocal | | 2 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M + + M + + + + + + | 49 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Angiectasis | 2 | 7 2.3|
Cyst | X X | 15 |
Pigmentation, Hemosiderin | | 2 2.0|
Pars Distalis, Hyperplasia, Focal | 2 | 3 2.0|
Pars Distalis, Hyperplasia | 3 3 | 4 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Inflammation, Subacute | | 1 3.0|
Ultimobranchial Cyst | X | 2 |
C-Cell, Hyperplasia | 2 2 | 10 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| | |
DAY ON TEST | 3| 3| 3| 3| 4| 3| 3| 3| 3| 0| | |
| 0| 0| 0| 0| 9| 0| 0| 0| 0| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
5 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
LOW FEMA | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 57 |
Inflammation, Chronic Active | | 2 2.5|
Duct, Ectasia | 3 2 | 7 2.4|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 60 |
Cyst | | 3 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Hydrometra | 2 | 3 2.7|
Inflammation, Chronic Active | | 1 3.0|
Cervix, Cyst | X X | 12 |
Cervix, Hypertrophy | | 1 3.0|
Cervix, Inflammation, Suppurative | | 2 3.0|
Endometrium, Cyst | | 1 |
Endometrium, Hyperplasia, Cystic | 3 3 2 | 6 2.8|
Endometrium, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 59 |
Hemorrhage | | 1 2.0|
Mediastinal, Hemorrhage | | 7 2.1|
Mediastinal, Hyperplasia, Reticulum | | |
Cell | | 1 2.0|
Mediastinal, Pigmentation, | | |
Hemosiderin | | 7 2.0|
Mediastinal, Sinus, Ectasia | | 1 2.0|
Mesenteric, Hemorrhage | 2 2 | 3 2.0|
Mesenteric, Pigmentation, Hemosiderin| | 1 2.0|
Mesenteric, Sinus, Ectasia | 2 3 | 14 2.1|
Pancreatic, Hemorrhage | | 2 2.0|
Pancreatic, Pigmentation, Hemosiderin| | 4 2.3|
Pancreatic, Sinus, Ectasia | | 1 2.0|
Renal, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
Renal, Pigmentation, Hemosiderin | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M + | 52 |
Hyperplasia, Plasma Cell | | 6 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| | |
DAY ON TEST | 3| 3| 3| 3| 4| 3| 3| 3| 3| 0| | |
| 0| 0| 0| 0| 9| 0| 0| 0| 0| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
5 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
LOW FEMA | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Sinus, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Ectopic Tissue | | 2 |
Fibrosis, Focal | | 4 2.8|
Hematopoietic Cell Proliferation | 3 2 | 3 3.0|
Red Pulp, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + | 51 |
Congestion | | 1 3.0|
Cyst | | 1 |
Ectopic Tissue | | 1 |
Hemorrhage | | 1 2.0|
Epithelial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 | 48 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + M | 55 |
Duct, Ectasia | 3 | 7 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 2 |
Femur, Osteopetrosis | | 1 3.0|
Vertebra, Osteopetrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Cerebrum, Gliosis | | 1 2.0|
Cerebrum, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + | 60 |
Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | | 3 2.3|
Fungus | | 1 |
Hemorrhage | 1 | 5 1.2|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 | 51 1.0|
Inflammation, Focal, Granulomatous | | 1 3.0|
Pigmentation, Diffuse, Hemosiderin | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| | |
DAY ON TEST | 3| 3| 3| 3| 4| 3| 3| 3| 3| 0| | |
| 0| 0| 0| 0| 9| 0| 0| 0| 0| 2| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
5 MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| | L |
LOW FEMA | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 | 51 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 | 3 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | X | 1 |
Inflammation, Suppurative | 2 2 | 4 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + + | 3 |
Middle Ear, Inflammation, Suppurative| 2 | 1 2.0|
__________________________________________________________________________|____________|
Eye | + + | 7 |
Cataract | 3 | 3 3.0|
Necrosis | | 2 4.0|
Retina, Degeneration | 3 | 2 3.0|
Sclera, Metaplasia, Osseous | 1 | 2 1.5|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Infiltration Cellular, Lymphocyte | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Nephropathy | 1 1 1 3 1 2 2 1 | 51 1.6|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 58 |
Infiltration Cellular, Lymphocyte | 2 | 4 1.3|
Serosa, Inflammation, Chronic | | 1 3.0|
Transitional Epithelium, Hyperplasia,| | |
Focal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 6| 6| 6| 6| 6| 7| 7| 6| 5| 4| 7| 6| 6| 1| 1| 7| 7| 1| 1| 1|
DAY ON TEST | 2| 2| 2| 5| 4| 4| 4| 4| 4| 4| 2| 2| 9| 1| 9| 2| 6| 4| 5| 0| 2| 2| 4| 0| 0|
| 9| 9| 9| 9| 9| 7| 6| 6| 6| 2| 9| 9| 1| 6| 5| 9| 0| 9| 2| 3| 9| 9| 1| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
10MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
HIGH FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + A + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + A + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + A + + + + A + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Basophilic Focus, Focal | |
Basophilic Focus | 2 1 |
Basophilic Focus, Multifocal | 2 2 2 |
Congestion | |
Fatty Change, Diffuse | |
Fatty Change, Multifocal | |
Hepatodiaphragmatic Nodule | X X X X X X X |
Inflammation, Granulomatous, | |
Multifocal | 1 1 1 1 1 1 1 1 1 1 2 2 |
Bile Duct, Hyperplasia | 2 2 1 2 1 2 3 2 2 2 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + |
Fat, Necrosis, Focal | 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + A + +|
Acinus, Atrophy | 1 2 3 1 2 |
Acinus, Cytoplasmic Alteration, Focal| 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + A + +|
Hyperplasia, Focal | 1 2 |
Inflammation, Chronic | |
Ulcer | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + A + +|
Degeneration, Cystic | 2 1 2 1 1 1 1 2 2 1 3 2 2 2 1 1 2 |
Ulcer | |
__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 6| 6| 6| 6| 6| 7| 7| 6| 5| 4| 7| 6| 6| 1| 1| 7| 7| 1| 1| 1|
DAY ON TEST | 2| 2| 2| 5| 4| 4| 4| 4| 4| 4| 2| 2| 9| 1| 9| 2| 6| 4| 5| 0| 2| 2| 4| 0| 0|
| 9| 9| 9| 9| 9| 7| 6| 6| 6| 2| 9| 9| 1| 6| 5| 9| 0| 9| 2| 3| 9| 9| 1| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
10MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
HIGH FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Artery, Degeneration | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Focal | |
Hyperplasia, Multifocal | |
Necrosis, Multifocal | |
Vacuolization Cytoplasmic, Focal | 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + M + + + + + +|
Hyperplasia, Focal | |
Bilateral, Hyperplasia, Focal | |
Bilateral, Hyperplasia, Multifocal | 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + + + M M + + + + + + + + M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | X X X X X X X X X X |
Hemorrhage | 2 |
Pars Distalis, Hyperplasia, Focal | 1 2 |
Pars Distalis, Hyperplasia | 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + M M + + M M M|
Duct, Ectasia | 3 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cervix, Cyst | X X X |
Cervix, Inflammation, Suppurative | 2 |
Endometrium, Cyst | 3 X |
Endometrium, Hyperplasia, Cystic | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 6| 6| 6| 6| 6| 7| 7| 6| 5| 4| 7| 6| 6| 1| 1| 7| 7| 1| 1| 1|
DAY ON TEST | 2| 2| 2| 5| 4| 4| 4| 4| 4| 4| 2| 2| 9| 1| 9| 2| 6| 4| 5| 0| 2| 2| 4| 0| 0|
| 9| 9| 9| 9| 9| 7| 6| 6| 6| 2| 9| 9| 1| 6| 5| 9| 0| 9| 2| 3| 9| 9| 1| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
10MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
HIGH FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Hemosiderin | 2 |
Mediastinal, Hemorrhage | 2 3 2 |
Mediastinal, Pigmentation, | |
Hemosiderin | 2 |
Mesenteric, Hemorrhage | 3 |
Mesenteric, Sinus, Ectasia | 2 2 |
Pancreatic, Pigmentation, Hemosiderin| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + M + + + + + + M|
Hemorrhage | 2 |
Hyperplasia, Plasma Cell | 3 3 |
Pigmentation, Hemosiderin | |
Sinus, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | |
Fibrosis, Focal | 4 |
Hemorrhage, Focal | |
Inflammation, Necrotizing | 4 |
Red Pulp, Atrophy | |
__________________________________________________________________________|
Thymus | + + + + + + M + M + + + M + + + + + + + M M + + +|
Congestion | |
Cyst | X X |
Depletion Lymphoid | |
Hemorrhage | 2|
Epithelial Cell, Hyperplasia | 2 2 2 2 2 1 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Duct, Ectasia | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + A + +|
Hemorrhage | |
Cerebrum, Necrosis | 2 2 2 1 4 2 2 4 4 3 3 3 3 2 2 4 4|
Hippocampus, Necrosis | 3 |
Thalamus, Necrosis | 3 1 2 2 2 1 2 2 4 4 2 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 6| 6| 6| 6| 6| 7| 7| 6| 5| 4| 7| 6| 6| 1| 1| 7| 7| 1| 1| 1|
DAY ON TEST | 2| 2| 2| 5| 4| 4| 4| 4| 4| 4| 2| 2| 9| 1| 9| 2| 6| 4| 5| 0| 2| 2| 4| 0| 0|
| 9| 9| 9| 9| 9| 7| 6| 6| 6| 2| 9| 9| 1| 6| 5| 9| 0| 9| 2| 3| 9| 9| 1| 8| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
10MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
HIGH FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 3 3 3 4 3 3 3|
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Alveolar Epithelium, Hyperplasia | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Fungus | |
Hemorrhage | |
Inflammation, Suppurative | 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Eye | + |
Cataract | |
Retina, Degeneration | |
__________________________________________________________________________|
Harderian Gland | + |
Infiltration Cellular, Lymphocyte | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Nephropathy | 1 2 1 1 2 2 1 3 1 2 1 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 0| 7| 4| 1| 1| 7| 6| 6| 5| 2| 7| 7| 7| 6| 6| 7| 7| 7| 5| 1| 7| 6| 6| 6| 3|
DAY ON TEST | 6| 2| 8| 0| 0| 2| 8| 5| 0| 0| 2| 2| 0| 6| 1| 2| 2| 2| 6| 0| 2| 5| 5| 5| 9|
| 5| 9| 8| 8| 6| 9| 8| 4| 2| 1| 9| 9| 5| 7| 0| 9| 9| 9| 9| 9| 9| 0| 4| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
10MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
HIGH FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + A + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + A + + + + + + + + + + A + A + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + + + + + A + A + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + A + + + + + + + + + + A + A + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + A + + + + + + + + + + A + A + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus, Focal | 2 |
Basophilic Focus | |
Basophilic Focus, Multifocal | 2 2 2 2 2 2 2 2 2 2|
Congestion | |
Fatty Change, Diffuse | |
Fatty Change, Multifocal | 1 1 |
Hepatodiaphragmatic Nodule | X X X |
Inflammation, Granulomatous, | |
Multifocal | 1 1 1 1 2 1 1 1 1 1 1|
Bile Duct, Hyperplasia | 2 1 1 1 2 2 2 2 2 2 2 1 |
Centrilobular, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis, Focal | 4 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 1 1 1|
Acinus, Cytoplasmic Alteration, Focal| 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Inflammation, Chronic | 1 2 |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 1 1 1 2 1 1 2 2 2 1 1 |
Ulcer | |
__________________________________________________________________________|
Tooth | |
Peridontal Tissue, Inflammation, | |
Chronic Active | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 0| 7| 4| 1| 1| 7| 6| 6| 5| 2| 7| 7| 7| 6| 6| 7| 7| 7| 5| 1| 7| 6| 6| 6| 3|
DAY ON TEST | 6| 2| 8| 0| 0| 2| 8| 5| 0| 0| 2| 2| 0| 6| 1| 2| 2| 2| 6| 0| 2| 5| 5| 5| 9|
| 5| 9| 8| 8| 6| 9| 8| 4| 2| 1| 9| 9| 5| 7| 0| 9| 9| 9| 9| 9| 9| 0| 4| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
10MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
HIGH FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Artery, Degeneration | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Hyperplasia, Focal | 2 2 |
Hyperplasia, Multifocal | |
Necrosis, Multifocal | |
Vacuolization Cytoplasmic, Focal | 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + I + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Bilateral, Hyperplasia, Focal | 2 |
Bilateral, Hyperplasia, Multifocal | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + M + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 |
Cyst | X X X X X |
Hemorrhage | |
Pars Distalis, Hyperplasia, Focal | 2 2 2 |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + A + + + + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + + + M + + + + + + + + + M + + + + +|
Duct, Ectasia | 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Cervix, Cyst | X |
Cervix, Inflammation, Suppurative | |
Endometrium, Cyst | X |
Endometrium, Hyperplasia, Cystic | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 |
_____________________________________________________________________________________________________________________|
Page 38
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 0| 7| 4| 1| 1| 7| 6| 6| 5| 2| 7| 7| 7| 6| 6| 7| 7| 7| 5| 1| 7| 6| 6| 6| 3|
DAY ON TEST | 6| 2| 8| 0| 0| 2| 8| 5| 0| 0| 2| 2| 0| 6| 1| 2| 2| 2| 6| 0| 2| 5| 5| 5| 9|
| 5| 9| 8| 8| 6| 9| 8| 4| 2| 1| 9| 9| 5| 7| 0| 9| 9| 9| 9| 9| 9| 0| 4| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
10MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
HIGH FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Hemosiderin | |
Mediastinal, Hemorrhage | 2 2 3 2 |
Mediastinal, Pigmentation, | |
Hemosiderin | 2 2 2 2 |
Mesenteric, Hemorrhage | 3 |
Mesenteric, Sinus, Ectasia | 2 2 |
Pancreatic, Pigmentation, Hemosiderin| |
__________________________________________________________________________|
Lymph Node, Mandibular | + + M M + + + + + + + + + + + + + + + + M + +|
Hemorrhage | 2 |
Hyperplasia, Plasma Cell | 2 2 2 |
Pigmentation, Hemosiderin | 2 |
Sinus, Ectasia | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | X X |
Fibrosis, Focal | |
Hemorrhage, Focal | |
Inflammation, Necrotizing | |
Red Pulp, Atrophy | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + I + + + + M + + M + + M + + + + M|
Congestion | |
Cyst | |
Depletion Lymphoid | 2 |
Hemorrhage | 2 |
Epithelial Cell, Hyperplasia | 2 1 2 1 2 1 2 2 2 2 1 2 2 1 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + + + + + + + + + + + M + + +|
Duct, Ectasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Cerebrum, Necrosis | 4 2 3 4 2 3 3 2 3 2 3 |
Hippocampus, Necrosis | 4 2 |
Thalamus, Necrosis | 4 4 3 3 3 2 4 3 |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 39
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 0| 7| 4| 1| 1| 7| 6| 6| 5| 2| 7| 7| 7| 6| 6| 7| 7| 7| 5| 1| 7| 6| 6| 6| 3|
DAY ON TEST | 6| 2| 8| 0| 0| 2| 8| 5| 0| 0| 2| 2| 0| 6| 1| 2| 2| 2| 6| 0| 2| 5| 5| 5| 9|
| 5| 9| 8| 8| 6| 9| 8| 4| 2| 1| 9| 9| 5| 7| 0| 9| 9| 9| 9| 9| 9| 0| 4| 3| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
10MG/KG | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
HIGH FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 3 3 3 3 3 4 2 3|
Hemorrhage | 1 1 1 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 1 |
Alveolar Epithelium, Hyperplasia | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Fungus | X X |
Hemorrhage | |
Inflammation, Suppurative | 2 3 3 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + |
Cataract | 3 |
Retina, Degeneration | 3 |
__________________________________________________________________________|
Harderian Gland | |
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy | 1 2 1 1 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 40
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 2| 7| 7| 5| 4| 4| | |
DAY ON TEST | 2| 2| 2| 1| 0| 2| 2| 0| 6| 4| | |
| 9| 9| 9| 2| 6| 9| 9| 2| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
10MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
HIGH FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Intestine Small | + + + A + + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + + + + | 49 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Angiectasis | 2 | 4 2.0|
Basophilic Focus, Focal | | 1 2.0|
Basophilic Focus | 2 2 2 | 5 1.8|
Basophilic Focus, Multifocal | 2 2 2 2 2 | 18 2.0|
Congestion | 3 | 1 3.0|
Fatty Change, Diffuse | 2 | 1 2.0|
Fatty Change, Multifocal | | 2 1.0|
Hepatodiaphragmatic Nodule | X | 11 |
Inflammation, Granulomatous, | | |
Multifocal | 1 1 1 1 1 | 28 1.1|
Bile Duct, Hyperplasia | 3 1 2 2 2 | 27 1.8|
Centrilobular, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + | 7 |
Fat, Necrosis, Focal | 4 3 | 7 3.9|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 58 |
Acinus, Atrophy | 1 1 | 11 1.5|
Acinus, Cytoplasmic Alteration, Focal| | 2 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 57 |
Hyperplasia, Focal | | 2 1.5|
Inflammation, Chronic | | 2 1.5|
Ulcer | 3 | 2 3.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 57 |
Degeneration, Cystic | 2 1 2 2 2 2 2 | 37 1.6|
Ulcer | 3 | 1 3.0|
__________________________________________________________________________|____________|
Tooth | + | 1 |
Peridontal Tissue, Inflammation, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 2| 7| 7| 5| 4| 4| | |
DAY ON TEST | 2| 2| 2| 1| 0| 2| 2| 0| 6| 4| | |
| 9| 9| 9| 2| 6| 9| 9| 2| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
10MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
HIGH FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Chronic Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 58 |
Cardiomyopathy | 2 1 1 1 | 19 1.7|
Artery, Degeneration | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + | 58 |
Angiectasis | | 2 2.0|
Hyperplasia, Focal | | 2 2.0|
Hyperplasia, Multifocal | 2 | 1 2.0|
Necrosis, Multifocal | 3 | 1 3.0|
Vacuolization Cytoplasmic, Focal | | 5 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + M + + + + + | 56 |
Hyperplasia, Focal | 2 | 1 2.0|
Bilateral, Hyperplasia, Focal | | 1 2.0|
Bilateral, Hyperplasia, Multifocal | | 1 2.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + M + + + M | 48 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 59 |
Angiectasis | 2 2 | 5 2.0|
Cyst | | 15 |
Hemorrhage | | 1 2.0|
Pars Distalis, Hyperplasia, Focal | 1 | 6 1.7|
Pars Distalis, Hyperplasia | 3 | 3 2.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + M | 56 |
Ultimobranchial Cyst | | 2 |
C-Cell, Hyperplasia | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M + + M + + + + + | 49 |
Duct, Ectasia | 3 | 4 2.8|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 59 |
Congestion | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 2| 7| 7| 5| 4| 4| | |
DAY ON TEST | 2| 2| 2| 1| 0| 2| 2| 0| 6| 4| | |
| 9| 9| 9| 2| 6| 9| 9| 2| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
10MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
HIGH FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Cyst | | 4 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 59 |
Cervix, Cyst | X | 5 |
Cervix, Inflammation, Suppurative | | 1 2.0|
Endometrium, Cyst | | 3 3.0|
Endometrium, Hyperplasia, Cystic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
Atrophy | | 3 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 59 |
Pigmentation, Hemosiderin | | 1 2.0|
Mediastinal, Hemorrhage | 2 2 | 9 2.2|
Mediastinal, Pigmentation, | | |
Hemosiderin | 2 | 6 2.0|
Mesenteric, Hemorrhage | | 2 3.0|
Mesenteric, Sinus, Ectasia | 2 2 | 6 2.0|
Pancreatic, Pigmentation, Hemosiderin| 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M + + | 50 |
Hemorrhage | | 2 2.0|
Hyperplasia, Plasma Cell | 2 | 6 2.3|
Pigmentation, Hemosiderin | | 1 2.0|
Sinus, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Ectopic Tissue | | 2 |
Fibrosis, Focal | | 1 4.0|
Hemorrhage, Focal | 2 | 1 2.0|
Inflammation, Necrotizing | | 1 4.0|
Red Pulp, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 49 |
Congestion | 2 | 1 2.0|
Cyst | | 2 |
Depletion Lymphoid | | 1 2.0|
Hemorrhage | 2 | 3 2.0|
Epithelial Cell, Hyperplasia | 2 2 2 1 1 2 2 | 35 1.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 56 |
Duct, Ectasia | 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 2| 7| 7| 5| 4| 4| | |
DAY ON TEST | 2| 2| 2| 1| 0| 2| 2| 0| 6| 4| | |
| 9| 9| 9| 2| 6| 9| 9| 2| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
10MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
HIGH FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 58 |
Hemorrhage | | 1 3.0|
Cerebrum, Necrosis | 2 3 3 2 3 | 33 2.8|
Hippocampus, Necrosis | | 3 3.0|
Thalamus, Necrosis | 2 2 | 21 2.6|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Spinal Cord | M + + + + + + + + + | 58 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 59 |
Congestion | 2 3 3 | 21 3.0|
Hemorrhage | | 5 1.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 | 42 1.0|
Pigmentation | 1 1 1 1 1 1 1 | 42 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 2 1.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Foreign Body | | 2 2.0|
Fungus | | 2 |
Hemorrhage | 2 | 1 2.0|
Inflammation, Suppurative | | 5 2.4|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 3 |
__________________________________________________________________________|____________|
Eye | + | 3 |
Cataract | | 1 3.0|
Retina, Degeneration | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Infiltration Cellular, Lymphocyte | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 2| 7| 7| 5| 4| 4| | |
DAY ON TEST | 2| 2| 2| 1| 0| 2| 2| 0| 6| 4| | |
| 9| 9| 9| 2| 6| 9| 9| 2| 8| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
10MG/KG | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| | L |
HIGH FEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 59 |
Cyst | | 2 |
Nephropathy | 1 2 1 1 1 1 | 23 1.4|
__________________________________________________________________________|____________|
Urinary Bladder | + + M + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 1| 7| 7| 6| 6| 5|
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 7| 3| 3| 2| 3| 3| 9| 5| 3| 3| 3| 9| 5| 3| 3| 9| 8| 9|
| 5| 6| 6| 6| 5| 6| 6| 4| 3| 6| 7| 6| 6| 4| 2| 6| 6| 6| 5| 1| 6| 6| 4| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
VEHICLEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + A + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + A + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + A + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + A + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + A + + A + + + + + + + A + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + A + + A + + + A + + + A + + + + + |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 2 2 2 2 2 3 2 |
Basophilic Focus | 2 2 |
Basophilic Focus, Multifocal | 2 2 |
Congestion | |
Degeneration, Cystic | |
Fatty Change, Diffuse | |
Fatty Change, Focal | 2 |
Fatty Change, Multifocal | |
Fibrosis | 2 |
Hepatodiaphragmatic Nodule | X X |
Hyperplasia, Multifocal, Nodular | 2 |
Inflammation, Granulomatous, | |
Multifocal | 1 1 1 |
Leukocytosis | 3 1 |
Necrosis, Focal | 3 |
Necrosis, Multifocal | 2 |
Pigmentation | 2 |
Thrombosis | |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 3 3 2 2 2 2 3 2 3 2|
Centrilobular, Hemorrhage | |
Centrilobular, Necrosis | 3|
Periportal, Fatty Change | |
__________________________________________________________________________|
Mesentery | + + +|
Fat, Necrosis, Focal | 3 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Focal | |
Acinus, Atrophy | 3 2 3 1 3 1 2 2 2 2 1 2 |
Acinus, Hyperplasia, Focal | 2 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + M + + +|
Acinus, Atrophy | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + A + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Ulcer | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 1| 7| 7| 6| 6| 5|
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 7| 3| 3| 2| 3| 3| 9| 5| 3| 3| 3| 9| 5| 3| 3| 9| 8| 9|
| 5| 6| 6| 6| 5| 6| 6| 4| 3| 6| 7| 6| 6| 4| 2| 6| 6| 6| 5| 1| 6| 6| 4| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
VEHICLEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 |
Erosion | |
Inflammation, Chronic Active | |
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 1 2 2 2 2 1 2 2 2 1 3 2 2 2 2 |
Atrium, Dilatation | 4 |
Atrium, Thrombosis | 3 4 4 4|
Myocardium, Degeneration, Hyaline | 1 |
Valve, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Hyperplasia, Focal | 2 1 2 2 1 |
Necrosis | |
Vacuolization Cytoplasmic, Focal | 2 2 2 1 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + M + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 3 2 1 2 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + M M + + + + M M + + + + M + + + + M M M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hemorrhage | |
Pigmentation, Hemosiderin | 2 2 |
Pars Distalis, Hyperplasia, Focal | 2 |
Pars Distalis, Hyperplasia | 3 |
Pars Distalis, Hyperplasia, | |
Multifocal | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 3 2 1 |
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Thrombosis | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 1| 7| 7| 6| 6| 5|
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 7| 3| 3| 2| 3| 3| 9| 5| 3| 3| 3| 9| 5| 3| 3| 9| 8| 9|
| 5| 6| 6| 6| 5| 6| 6| 4| 3| 6| 7| 6| 6| 4| 2| 6| 6| 6| 5| 1| 6| 6| 4| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
VEHICLEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Hyperplasia, Focal, Glandular | |
Inflammation, Chronic Active | 2 4 2 2 2 4 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 2 3 2 4 |
Epithelium, Hyperplasia, Focal | 2 2 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + A + + + + + + + + + + + + + +|
Atrophy | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypospermia | 3 |
Arteriole, Inflammation, Necrotizing | |
Interstitial Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pigmentation, Hemosiderin | 2 |
Mediastinal, Hemorrhage | 2 2 |
Mediastinal, Infiltration Cellular, | |
Mast Cell | 2 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 2 |
Mediastinal, Pigmentation, | |
Hemosiderin | |
Mediastinal, Sinus, Ectasia | 3 |
Mesenteric, Hemorrhage | 2 |
Mesenteric, Sinus, Ectasia | 3 2 2 2 4 |
Pancreatic, Hemorrhage | |
Pancreatic, Sinus, Ectasia | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + + M + + +|
Degeneration, Cystic | 3 |
Hemorrhage | 2 2 |
Sinus, Ectasia | 3 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | X |
Fibrosis, Diffuse | 3 |
Fibrosis, Focal | 2 |
Fibrosis, Multifocal | 3 |
Hematopoietic Cell Proliferation | 3|
Red Pulp, Atrophy | 4 |
__________________________________________________________________________|
Thymus | + + + M + + + + M + + + + + + + + M + + + + + M M|
Ectopic Tissue | X |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 1| 7| 7| 6| 6| 5|
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 7| 3| 3| 2| 3| 3| 9| 5| 3| 3| 3| 9| 5| 3| 3| 9| 8| 9|
| 5| 6| 6| 6| 5| 6| 6| 4| 3| 6| 7| 6| 6| 4| 2| 6| 6| 6| 5| 1| 6| 6| 4| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
VEHICLEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hemorrhage | 2 3 |
Epithelial Cell, Hyperplasia | 1 2 2 2 2 2 3 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + M M M + A + + + M + + + + M M + + M +|
Galactocele | |
Inflammation, Granulomatous | |
Duct, Ectasia | |
__________________________________________________________________________|
Skin | + + + + + + + + + + A + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 3 |
Hydrocephalus | 4 |
Inflammation, Chronic | 3 |
Mineralization | |
Cerebrum, Inflammation, Focal, | |
Suppurative | |
__________________________________________________________________________|
Peripheral Nerve | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + M + + + M + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 4 |
Hemorrhage | 1 2 |
Infiltration Cellular, Histiocyte | 3 1 1 |
Inflammation, Focal, Granulomatous | 2 |
Inflammation, Multifocal, Suppurative| |
Leukocytosis | 2|
Necrosis, Focal | |
Pigmentation | 2 3 |
Pigmentation, Hemoglobin | 1 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 2 2 |
Bronchiole, Inflammation, Suppurative| |
Bronchus, Inflammation, Suppurative | |
Interstitium, Inflammation | 3 1 1 |
Peribronchiolar, Alveolus, | |
Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 6| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 1| 7| 7| 6| 6| 5|
DAY ON TEST | 3| 3| 3| 3| 9| 3| 3| 7| 3| 3| 2| 3| 3| 9| 5| 3| 3| 3| 9| 5| 3| 3| 9| 8| 9|
| 5| 6| 6| 6| 5| 6| 6| 4| 3| 6| 7| 6| 6| 4| 2| 6| 6| 6| 5| 1| 6| 6| 4| 1| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
VEHICLEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fungus | X |
Hemorrhage | 2 2 2 |
Hyperkeratosis, Focal | 3 |
Inflammation, Chronic Active | 2 |
Inflammation, Suppurative | 2 2 |
Sinus, Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + A + + |
Cataract | |
Necrosis | 4 |
Conjunctiva, Inflammation, Chronic | |
Active | 3 |
Retina, Degeneration | |
Sclera, Metaplasia, Osseous | 3 |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Inflammation, Multifocal, Suppurative| |
Necrosis, Focal | |
Nephropathy | 3 3 3 2 2 3 3 3 2 3 3 3 3 3 3 3 3 1 2 3 2 3 2|
Pigmentation | 3 3 2|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
Inflammation, Suppurative | |
Ulcer | |
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 6| 6| 5| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 3| 2| 8| 3| 2| 2| 6| 3| 1| 5| 8| 4| 3| 3| 3| 9| 9| 3| 0| 0| 9| 7|
| 6| 6| 6| 6| 0| 1| 6| 7| 6| 1| 6| 9| 8| 9| 9| 6| 6| 6| 7| 3| 6| 3| 3| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
VEHICLEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + A A + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A A + + + A + + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A A + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + A A + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + A + + + A A A + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + + + A A A + + + + A + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + A + + + A A A + + + A A + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + M + + + A + + + A A A + + + A + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 |
Basophilic Focus | |
Basophilic Focus, Multifocal | |
Congestion | 2 |
Degeneration, Cystic | 3 |
Fatty Change, Diffuse | |
Fatty Change, Focal | |
Fatty Change, Multifocal | 1 |
Fibrosis | |
Hepatodiaphragmatic Nodule | |
Hyperplasia, Multifocal, Nodular | |
Inflammation, Granulomatous, | |
Multifocal | 1 |
Leukocytosis | 2 2|
Necrosis, Focal | |
Necrosis, Multifocal | |
Pigmentation | |
Thrombosis | |
Bile Duct, Hyperplasia | 3 2 2 2 2 2 3 2 2 3 2 3 3 2 2 2 2 3 3 3 3 2|
Centrilobular, Hemorrhage | |
Centrilobular, Necrosis | 2 |
Periportal, Fatty Change | 3 |
__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Necrosis, Focal | 4 4 3 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + A + + + + + + + + + +|
Cytoplasmic Alteration, Focal | 2 |
Acinus, Atrophy | 2 2 3 |
Acinus, Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + M + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Ulcer | 3 3 3 |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 6| 6| 5| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 3| 2| 8| 3| 2| 2| 6| 3| 1| 5| 8| 4| 3| 3| 3| 9| 9| 3| 0| 0| 9| 7|
| 6| 6| 6| 6| 0| 1| 6| 7| 6| 1| 6| 9| 8| 9| 9| 6| 6| 6| 7| 3| 6| 3| 3| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
VEHICLEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1|
Erosion | 2 |
Inflammation, Chronic Active | 2 |
Ulcer | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 1 2 2 2 2 1 2 2 2 2 2 2 2 |
Atrium, Dilatation | |
Atrium, Thrombosis | 3 4 4 4 |
Myocardium, Degeneration, Hyaline | |
Valve, Inflammation, Suppurative | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Hemorrhage | 3 |
Hyperplasia, Focal | 2 |
Necrosis | |
Vacuolization Cytoplasmic, Focal | 1 2 2 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + M + + + + +|
Hyperplasia, Focal | 2 2 2 3 2 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + M + + M + + + M + + + M M + M + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Hemorrhage | 4|
Pigmentation, Hemosiderin | 2 |
Pars Distalis, Hyperplasia, Focal | 2 |
Pars Distalis, Hyperplasia | |
Pars Distalis, Hyperplasia, | |
Multifocal | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | |
C-Cell, Hyperplasia | 2 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Thrombosis | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 6| 6| 5| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 3| 2| 8| 3| 2| 2| 6| 3| 1| 5| 8| 4| 3| 3| 3| 9| 9| 3| 0| 0| 9| 7|
| 6| 6| 6| 6| 0| 1| 6| 7| 6| 1| 6| 9| 8| 9| 9| 6| 6| 6| 7| 3| 6| 3| 3| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
VEHICLEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Glandular | 2 |
Inflammation, Chronic Active | 1 1 2 2 1 2 2 2 2 2 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 3 3 2 2 4 4 |
Epithelium, Hyperplasia, Focal | 2 2 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypospermia | 3 4 |
Arteriole, Inflammation, Necrotizing | 2 |
Interstitial Cell, Hyperplasia | 2 1 2 2 2 2 2 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + M + + + + + + + + + + + + + + + +|
Pigmentation, Hemosiderin | |
Mediastinal, Hemorrhage | 2 2 |
Mediastinal, Infiltration Cellular, | |
Mast Cell | |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 2 |
Mediastinal, Pigmentation, | |
Hemosiderin | |
Mediastinal, Sinus, Ectasia | |
Mesenteric, Hemorrhage | 2 |
Mesenteric, Sinus, Ectasia | 3 |
Pancreatic, Hemorrhage | |
Pancreatic, Sinus, Ectasia | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + M + + + + + + +|
Degeneration, Cystic | |
Hemorrhage | |
Sinus, Ectasia | 3 3 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | X X X|
Fibrosis, Diffuse | |
Fibrosis, Focal | 3 3 2 3 2 2 |
Fibrosis, Multifocal | |
Hematopoietic Cell Proliferation | |
Red Pulp, Atrophy | |
__________________________________________________________________________|
Thymus | + M M + + M + + + + + M + + + + M M + + + + + + +|
Ectopic Tissue | |
_____________________________________________________________________________________________________________________|
Page 53
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 6| 6| 5| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 3| 2| 8| 3| 2| 2| 6| 3| 1| 5| 8| 4| 3| 3| 3| 9| 9| 3| 0| 0| 9| 7|
| 6| 6| 6| 6| 0| 1| 6| 7| 6| 1| 6| 9| 8| 9| 9| 6| 6| 6| 7| 3| 6| 3| 3| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
VEHICLEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hemorrhage | |
Epithelial Cell, Hyperplasia | 2 2 1 2 2 2 1 2 2 1|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + M + + + + + + M + + + + +|
Galactocele | X |
Inflammation, Granulomatous | 3 |
Duct, Ectasia | 2 3 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 3 3 3 |
Hydrocephalus | |
Inflammation, Chronic | |
Mineralization | 2 |
Cerebrum, Inflammation, Focal, | |
Suppurative | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 4 2|
Hemorrhage | 1 |
Infiltration Cellular, Histiocyte | 1 1 1 1 2 2 |
Inflammation, Focal, Granulomatous | |
Inflammation, Multifocal, Suppurative| |
Leukocytosis | 2 |
Necrosis, Focal | 3 |
Pigmentation | 1 1 1 1 |
Pigmentation, Hemoglobin | |
Thrombosis | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 3 3 2 2 3 |
Bronchiole, Inflammation, Suppurative| 4 |
Bronchus, Inflammation, Suppurative | |
Interstitium, Inflammation | |
Peribronchiolar, Alveolus, | |
Inflammation, Suppurative | 4 |
_____________________________________________________________________________________________________________________|
Page 54
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 6| 6| 5| 7| 7| 6| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 3| 2| 8| 3| 2| 2| 6| 3| 1| 5| 8| 4| 3| 3| 3| 9| 9| 3| 0| 0| 9| 7|
| 6| 6| 6| 6| 0| 1| 6| 7| 6| 1| 6| 9| 8| 9| 9| 6| 6| 6| 7| 3| 6| 3| 3| 5| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|
0 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|
VEHICLEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Fungus | X |
Hemorrhage | 3 |
Hyperkeratosis, Focal | |
Inflammation, Chronic Active | |
Inflammation, Suppurative | 2 2 2 |
Sinus, Inflammation, Suppurative | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + + |
__________________________________________________________________________|
Eye | + + + + |
Cataract | 4 4 |
Necrosis | |
Conjunctiva, Inflammation, Chronic | |
Active | 2 |
Retina, Degeneration | 3 4 |
Sclera, Metaplasia, Osseous | 2 |
__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Multifocal, Suppurative| |
Necrosis, Focal | 2 |
Nephropathy | 3 3 2 3 2 4 3 3 2 2 2 2 2 2 2 3 3 3 4 2 3 3 3 2 3|
Pigmentation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 2|
Inflammation, Suppurative | 4 |
Ulcer | 4 |
_____________________________________________________________________________________________________________________|
Page 55
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 3| 6| 6| 6| 6| 5| | |
DAY ON TEST | 1| 4| 0| 6| 0| 9| 7| 5| 0| 5| | |
| 1| 0| 3| 8| 0| 0| 8| 4| 4| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
VEHICLEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Intestine Large | + + A A A + A A + + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A A A + A A + + | 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A A A + A A + + | 50 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A A A + A A + + | 50 |
__________________________________________________________________________|____________|
Intestine Small | + + A A A + A A + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A A A + A A + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A A A + A A + + | 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A A A + A A + + | 42 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 13 2.1|
Basophilic Focus | | 2 2.0|
Basophilic Focus, Multifocal | | 2 2.0|
Congestion | | 1 2.0|
Degeneration, Cystic | 3 2 2 | 4 2.5|
Fatty Change, Diffuse | 4 | 1 4.0|
Fatty Change, Focal | | 1 2.0|
Fatty Change, Multifocal | | 1 1.0|
Fibrosis | | 1 2.0|
Hepatodiaphragmatic Nodule | X | 3 |
Hyperplasia, Multifocal, Nodular | | 1 2.0|
Inflammation, Granulomatous, | | |
Multifocal | | 4 1.0|
Leukocytosis | 2 | 5 2.0|
Necrosis, Focal | | 1 3.0|
Necrosis, Multifocal | 2 | 2 2.0|
Pigmentation | | 1 2.0|
Thrombosis | 4 | 1 4.0|
Bile Duct, Hyperplasia | 3 2 2 2 3 2 3 2 | 53 2.3|
Centrilobular, Hemorrhage | 3 | 1 3.0|
Centrilobular, Necrosis | | 2 2.5|
Periportal, Fatty Change | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 9 |
Fat, Necrosis, Focal | | 6 3.7|
__________________________________________________________________________|____________|
Pancreas | + + A + + + A + + + | 57 |
Cytoplasmic Alteration, Focal | | 1 2.0|
Acinus, Atrophy | 2 1 2 | 18 2.0|
Acinus, Hyperplasia, Focal | | 5 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 3| 6| 6| 6| 6| 5| | |
DAY ON TEST | 1| 4| 0| 6| 0| 9| 7| 5| 0| 5| | |
| 1| 0| 3| 8| 0| 0| 8| 4| 4| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
VEHICLEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Acinus, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 58 |
Inflammation, Chronic Active | 3 | 2 2.5|
Ulcer | 4 1 | 5 2.8|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 58 |
Degeneration, Cystic | 2 1 1 1 | 37 1.1|
Erosion | | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 2 2 2 2 2 | 40 1.9|
Atrium, Dilatation | | 1 4.0|
Atrium, Thrombosis | 4 4 | 10 3.8|
Myocardium, Degeneration, Hyaline | | 1 1.0|
Valve, Inflammation, Suppurative | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Congestion | | 1 4.0|
Hemorrhage | | 1 3.0|
Hyperplasia, Focal | 1 | 7 1.6|
Necrosis | 3 | 1 3.0|
Vacuolization Cytoplasmic, Focal | 2 2 2 | 15 1.9|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + M + + M + M + + | 55 |
Hyperplasia, Focal | 2 2 | 15 2.1|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + A + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M + + + M + + | 41 |
__________________________________________________________________________|____________|
Pituitary Gland | + + A + + + + + + + | 59 |
Angiectasis | | 3 2.0|
Hemorrhage | | 1 4.0|
Pigmentation, Hemosiderin | 1 | 4 1.8|
Pars Distalis, Hyperplasia, Focal | 2 2 | 4 2.0|
Pars Distalis, Hyperplasia | | 1 3.0|
Pars Distalis, Hyperplasia, | | |
Multifocal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 3| 6| 6| 6| 6| 5| | |
DAY ON TEST | 1| 4| 0| 6| 0| 9| 7| 5| 0| 5| | |
| 1| 0| 3| 8| 0| 0| 8| 4| 4| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
VEHICLEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + A A + + + + + + | 57 |
Ultimobranchial Cyst | | 1 |
C-Cell, Hyperplasia | 2 | 5 2.0|
Follicle, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
Thrombosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 59 |
Hyperplasia, Focal, Glandular | | 1 2.0|
Inflammation, Chronic Active | 2 2 | 20 2.2|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | 2 | 13 2.7|
Epithelium, Hyperplasia, Focal | | 8 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 59 |
Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Hypospermia | 4 4 | 5 3.6|
Arteriole, Inflammation, Necrotizing | | 1 2.0|
Interstitial Cell, Hyperplasia | 2 | 10 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + A + + + + + + + | 59 |
Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + M + + + + + | 58 |
Pigmentation, Hemosiderin | | 1 2.0|
Mediastinal, Hemorrhage | 3 | 5 2.2|
Mediastinal, Infiltration Cellular, | | |
Mast Cell | | 1 2.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 2 2.0|
Mediastinal, Pigmentation, | | |
Hemosiderin | 4 | 1 4.0|
Mediastinal, Sinus, Ectasia | 2 | 2 2.5|
Mesenteric, Hemorrhage | 3 | 3 2.3|
Mesenteric, Sinus, Ectasia | | 6 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 3| 6| 6| 6| 6| 5| | |
DAY ON TEST | 1| 4| 0| 6| 0| 9| 7| 5| 0| 5| | |
| 1| 0| 3| 8| 0| 0| 8| 4| 4| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
VEHICLEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Pancreatic, Hemorrhage | 2 | 1 2.0|
Pancreatic, Sinus, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + + + | 55 |
Degeneration, Cystic | | 1 3.0|
Hemorrhage | 3 | 3 2.3|
Sinus, Ectasia | | 7 2.4|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Ectopic Tissue | | 4 |
Fibrosis, Diffuse | 4 4 | 3 3.7|
Fibrosis, Focal | | 7 2.4|
Fibrosis, Multifocal | | 1 3.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Red Pulp, Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 49 |
Ectopic Tissue | | 1 |
Hemorrhage | | 2 2.5|
Epithelial Cell, Hyperplasia | 2 2 2 1 2 2 | 29 1.9|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + + + A M + | 47 |
Galactocele | | 1 |
Inflammation, Granulomatous | | 1 3.0|
Duct, Ectasia | | 3 2.7|
__________________________________________________________________________|____________|
Skin | + + + + + + + M + + | 58 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Hemorrhage | 3 | 7 3.3|
Hydrocephalus | | 1 4.0|
Inflammation, Chronic | | 1 3.0|
Mineralization | | 1 2.0|
Cerebrum, Inflammation, Focal, | | |
Suppurative | 1 | 1 1.0|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + M + + + + + | 58 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + | 58 |
Hemorrhage | 3 | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 3| 6| 6| 6| 6| 5| | |
DAY ON TEST | 1| 4| 0| 6| 0| 9| 7| 5| 0| 5| | |
| 1| 0| 3| 8| 0| 0| 8| 4| 4| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
VEHICLEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | 3 | 6 3.0|
Hemorrhage | 2 | 4 1.5|
Infiltration Cellular, Histiocyte | 1 1 | 11 1.4|
Inflammation, Focal, Granulomatous | | 1 2.0|
Inflammation, Multifocal, Suppurative| 2 | 1 2.0|
Leukocytosis | | 2 2.0|
Necrosis, Focal | | 1 3.0|
Pigmentation | 1 1 | 8 1.4|
Pigmentation, Hemoglobin | | 1 1.0|
Thrombosis | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | | 8 2.5|
Bronchiole, Inflammation, Suppurative| 4 | 2 4.0|
Bronchus, Inflammation, Suppurative | 4 | 1 4.0|
Interstitium, Inflammation | | 3 1.7|
Peribronchiolar, Alveolus, | | |
Inflammation, Suppurative | 4 | 2 4.0|
__________________________________________________________________________|____________|
Nose | + + A + + + + + + + | 59 |
Congestion | | 1 3.0|
Fungus | X | 3 |
Hemorrhage | | 4 2.3|
Hyperkeratosis, Focal | | 1 3.0|
Inflammation, Chronic Active | | 1 2.0|
Inflammation, Suppurative | 2 | 6 2.0|
Sinus, Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 58 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 4 |
__________________________________________________________________________|____________|
Eye | + + + | 10 |
Cataract | 3 4 | 4 3.8|
Necrosis | | 1 4.0|
Conjunctiva, Inflammation, Chronic | | |
Active | | 2 2.5|
Retina, Degeneration | 3 4 | 4 3.5|
Sclera, Metaplasia, Osseous | 2 2 2 | 5 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 5| 3| 6| 6| 6| 6| 5| | |
DAY ON TEST | 1| 4| 0| 6| 0| 9| 7| 5| 0| 5| | |
| 1| 0| 3| 8| 0| 0| 8| 4| 4| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | L |
VEHICLEM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Zymbal's Gland | + | 3 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | | 4 |
Inflammation, Multifocal, Suppurative| 2 | 1 2.0|
Necrosis, Focal | | 1 2.0|
Nephropathy | 2 2 2 2 3 2 2 2 2 | 57 2.6|
Pigmentation | | 3 2.7|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | | 3 1.3|
Inflammation, Suppurative | | 1 4.0|
Ulcer | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6| 5|
DAY ON TEST | 2| 1| 0| 9| 8| 2| 3| 1| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 9| 1|
| 9| 7| 4| 3| 3| 9| 0| 6| 7| 3| 0| 0| 0| 0| 2| 0| 0| 0| 9| 7| 0| 0| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + A + + + + + A|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + A + + + + + A|
Epithelium, Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + A + + + + + A|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + A + + + + + A|
__________________________________________________________________________|
Intestine Small | + + + A + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + A + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + A + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus, Focal | |
Basophilic Focus, Multifocal | 2 |
Eosinophilic Focus, Focal | 2 |
Eosinophilic Focus, Multifocal | 2 |
Fatty Change, Diffuse | 3 |
Hepatodiaphragmatic Nodule | |
Leukocytosis | |
Necrosis, Focal | |
Bile Duct, Hyperplasia | 2 2 2 3 2 2 2 2 3 2 2 2 3 2 3 2 2 2 2 3 2 2 2|
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + + + + |
Inflammation, Focal, Granulomatous | 3 |
Necrosis, Focal | |
Fat, Necrosis, Focal | 4 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Multifocal | |
Acinus, Atrophy | 2 2 2 2 2 2 1 2 1 2 2|
Artery, Inflammation, Chronic | |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Inflammation, Chronic Active | |
Ulcer | 4 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 1 1 1 2 1 2 1 1 1 2 2 2 2 2 2 1 2 2 2 2 |
Degeneration | 1 |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6| 5|
DAY ON TEST | 2| 1| 0| 9| 8| 2| 3| 1| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 9| 1|
| 9| 7| 4| 3| 3| 9| 0| 6| 7| 3| 0| 0| 0| 0| 2| 0| 0| 0| 9| 7| 0| 0| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | 3 |
__________________________________________________________________________|
Tooth | |
Dysplasia | |
Peridontal Tissue, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 2 |
Thrombosis | X |
Atrium, Thrombosis | 4 |
Myocardium, Atrium, Inflammation, | |
Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia, Focal | 1 2 2 2 |
Hypertrophy, Focal | 1 |
Necrosis, Multifocal | 3 |
Vacuolization Cytoplasmic, Focal | 2 1 2 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 1 2 1 2 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + M + + + + + + M + M M M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | X |
Hemorrhage | 2 |
Pigmentation, Hemosiderin | 2 |
Pigmentation, Hemoglobin | 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 |
Pars Nervosa, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 |
Follicle, Cyst | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6| 5|
DAY ON TEST | 2| 1| 0| 9| 8| 2| 3| 1| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 9| 1|
| 9| 7| 4| 3| 3| 9| 0| 6| 7| 3| 0| 0| 0| 0| 2| 0| 0| 0| 9| 7| 0| 0| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia, Focal, Glandular | |
Inflammation, Chronic Active | 2 2 2 2 2 |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 2 3 |
Inflammation, Suppurative | |
Epithelium, Hyperplasia, Focal | 2 2 |
Serosa, Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Inflammation, Chronic Active | |
Serosa, Inflammation, Suppurative | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypospermia | 3 4 4 |
Interstitial Cell, Hyperplasia | 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + M + M + + + + + + + + + + + + +|
Pigmentation, Hemosiderin | 2 |
Mediastinal, Hematopoietic Cell | |
Proliferation | 2 |
Mediastinal, Hemorrhage | 2 3 2 3 3 |
Mediastinal, Pigmentation, | |
Hemosiderin | |
Mediastinal, Sinus, Ectasia | |
Mesenteric, Congestion | 4|
Mesenteric, Hemorrhage | 2 2 3|
Mesenteric, Sinus, Ectasia | 2 2 3|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + M + + + + + + + + + + + + +|
Hyperplasia, Plasma Cell | 3 2 3 |
Sinus, Ectasia | 2 2 2 2 3 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | |
Fibrosis, Diffuse | 3 3 |
Fibrosis, Focal | 3 2 |
Fibrosis, Multifocal | |
Hematopoietic Cell Proliferation | |
Hemorrhage | 3 |
Hyperplasia, Re Cell | 3 |
Necrosis, Focal | |
Necrosis, Multifocal | |
Red Pulp, Atrophy | |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6| 5|
DAY ON TEST | 2| 1| 0| 9| 8| 2| 3| 1| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 9| 1|
| 9| 7| 4| 3| 3| 9| 0| 6| 7| 3| 0| 0| 0| 0| 2| 0| 0| 0| 9| 7| 0| 0| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | + + + M + + + M M + M + + + + M + M M + M + + + +|
Cyst | X |
Hemorrhage | |
Epithelial Cell, Hyperplasia | 2 2 2 2 2 1 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Nodular | 2 |
Inflammation, Granulomatous | |
Duct, Ectasia | 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Brain Stem, Compression | |
Cerebrum, Necrosis | |
Medulla, Gliosis | 1 |
Thalamus, Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 2 |
Hemorrhage | |
Infiltration Cellular, Histiocyte | 2 1 1 1 1 1 1 1|
Pigmentation | 1 1 1 1 1 1 1 1|
Alveolar Epithelium, Hyperplasia, | |
Focal | |
Interstitium, Inflammation, Focal | |
Interstitium, Inflammation | 2 |
Peribronchiolar, Foreign Body | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Hemorrhage | 2 |
Inflammation, Suppurative | 2 3 |
Sinus, Inflammation, Chronic | |
Sinus, Inflammation, Chronic Active | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 5| 4| 7| 7| 7| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6| 5|
DAY ON TEST | 2| 1| 0| 9| 8| 2| 3| 1| 4| 0| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 9| 1|
| 9| 7| 4| 3| 3| 9| 0| 6| 7| 3| 0| 0| 0| 0| 2| 0| 0| 0| 9| 7| 0| 0| 0| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
__________________________________________________________________________|
Eye | + A|
Cataract | 3 |
Retina, Degeneration | 3 |
Sclera, Metaplasia, Osseous | |
__________________________________________________________________________|
Harderian Gland | + |
Pigmentation, Porphyrin | 3 |
__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Nephropathy | 2 2 2 2 1 2 2 3 3 1 2 2 1 2 2 3 2 2 3 1 3 3 4 3 |
Pigmentation | 3 2 |
Pelvis, Epithelium, Hyperplasia, | |
Focal | 2 |
Renal Tubule, Necrosis | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 2| 7| 7| 6| 6| 5| 7| 7| 6| 5| 2| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 4| 7| 2| 3| 1| 7| 3| 7| 3| 3| 4| 9| 2| 3| 3| 9| 4| 0| 3| 3| 3| 3| 3|
| 0| 3| 8| 9| 7| 0| 2| 3| 9| 6| 0| 0| 0| 1| 6| 0| 0| 8| 1| 2| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + A A A + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia, Focal | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + A A + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + A + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + A A A + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + A A + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 2 2 |
Basophilic Focus, Focal | 2 |
Basophilic Focus, Multifocal | 2 2 |
Eosinophilic Focus, Focal | |
Eosinophilic Focus, Multifocal | |
Fatty Change, Diffuse | |
Hepatodiaphragmatic Nodule | X |
Leukocytosis | 2 2 2 |
Necrosis, Focal | 2 |
Bile Duct, Hyperplasia | 2 3 3 3 2 2 3 2 3 2 2 2 2 3 2 3 2 2 2 2 2 2 2|
Centrilobular, Necrosis | 3 3 |
__________________________________________________________________________|
Mesentery | + + + + + + + |
Inflammation, Focal, Granulomatous | |
Necrosis, Focal | |
Fat, Necrosis, Focal | 4 3 4 3 2 4 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cytoplasmic Alteration, Multifocal | 2 |
Acinus, Atrophy | 2 3 1 1 1 3 2 |
Artery, Inflammation, Chronic | 3 |
Duct, Ectasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Inflammation, Chronic Active | 3 |
Ulcer | 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 2 2 1 2 1 1 2 2 2 2 1 2 2 2 2 2 2 1|
Degeneration | |
Infiltration Cellular, Focal, | |
Lymphocyte | 2 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 2| 7| 7| 6| 6| 5| 7| 7| 6| 5| 2| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 4| 7| 2| 3| 1| 7| 3| 7| 3| 3| 4| 9| 2| 3| 3| 9| 4| 0| 3| 3| 3| 3| 3|
| 0| 3| 8| 9| 7| 0| 2| 3| 9| 6| 0| 0| 0| 1| 6| 0| 0| 8| 1| 2| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Ulcer | |
__________________________________________________________________________|
Tooth | + |
Dysplasia | 3 |
Peridontal Tissue, Inflammation, | |
Suppurative | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 1 2 1 2 |
Thrombosis | |
Atrium, Thrombosis | 3 4 |
Myocardium, Atrium, Inflammation, | |
Chronic | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 4 |
Hyperplasia, Focal | 2 |
Hypertrophy, Focal | |
Necrosis, Multifocal | |
Vacuolization Cytoplasmic, Focal | 2 1 2 2 2 2 1|
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + M + + + + + + M + + +|
Hyperplasia, Focal | 2 2 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M M + + M + + + + + M + + M + + + M + M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | X X |
Hemorrhage | |
Pigmentation, Hemosiderin | |
Pigmentation, Hemoglobin | |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 2 |
Pars Nervosa, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + A + + + + + + + + + + + + + + + + + M + +|
C-Cell, Hyperplasia | 2 2 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 68
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 2| 7| 7| 6| 6| 5| 7| 7| 6| 5| 2| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 4| 7| 2| 3| 1| 7| 3| 7| 3| 3| 4| 9| 2| 3| 3| 9| 4| 0| 3| 3| 3| 3| 3|
| 0| 3| 8| 9| 7| 0| 2| 3| 9| 6| 0| 0| 0| 1| 6| 0| 0| 8| 1| 2| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Hyperplasia, Focal, Glandular | 3 |
Inflammation, Chronic Active | 1 3 2 |
Duct, Ectasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Inflammation, Suppurative | 3 |
Epithelium, Hyperplasia, Focal | 2 2 2 2 2 |
Serosa, Inflammation, Suppurative | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Inflammation, Chronic Active | |
Serosa, Inflammation, Suppurative | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypospermia | 4 4 4 4 |
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + M + + M + + +|
Pigmentation, Hemosiderin | |
Mediastinal, Hematopoietic Cell | |
Proliferation | |
Mediastinal, Hemorrhage | 3 2 2 |
Mediastinal, Pigmentation, | |
Hemosiderin | 2 2 |
Mediastinal, Sinus, Ectasia | 2 3 |
Mesenteric, Congestion | |
Mesenteric, Hemorrhage | 3 3 |
Mesenteric, Sinus, Ectasia | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + + M + + +|
Hyperplasia, Plasma Cell | 3 |
Sinus, Ectasia | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectopic Tissue | X |
Fibrosis, Diffuse | |
Fibrosis, Focal | 2 3 2|
Fibrosis, Multifocal | 3 |
Hematopoietic Cell Proliferation | |
Hemorrhage | |
Hyperplasia, Re Cell | |
Necrosis, Focal | |
Necrosis, Multifocal | |
Red Pulp, Atrophy | 3 |
_____________________________________________________________________________________________________________________|
Page 69
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 2| 7| 7| 6| 6| 5| 7| 7| 6| 5| 2| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 4| 7| 2| 3| 1| 7| 3| 7| 3| 3| 4| 9| 2| 3| 3| 9| 4| 0| 3| 3| 3| 3| 3|
| 0| 3| 8| 9| 7| 0| 2| 3| 9| 6| 0| 0| 0| 1| 6| 0| 0| 8| 1| 2| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Thymus | M + M + + + + + M + + + + M + + + + + + + + + + +|
Cyst | |
Hemorrhage | 2 |
Epithelial Cell, Hyperplasia | 1 2 2 2 2 2 2 1 2 2 2 2 2 1 2 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + M + + + + + M + + + + + M + + M + + + M + + +|
Hyperplasia, Nodular | |
Inflammation, Granulomatous | |
Duct, Ectasia | 3 |
__________________________________________________________________________|
Skin | + + + + M + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Brain Stem, Compression | 2 |
Cerebrum, Necrosis | 1 |
Medulla, Gliosis | |
Thalamus, Necrosis | |
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | 2 3 2 2 |
Infiltration Cellular, Histiocyte | 1 1 1 |
Pigmentation | 2 1 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 2 2 2 |
Interstitium, Inflammation, Focal | 1 |
Interstitium, Inflammation | |
Peribronchiolar, Foreign Body | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 4 |
Hemorrhage | 3 |
Inflammation, Suppurative | 3 |
Sinus, Inflammation, Chronic | 2 |
Sinus, Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 2| 7| 7| 6| 6| 5| 7| 7| 6| 5| 2| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 2| 4| 7| 2| 3| 1| 7| 3| 7| 3| 3| 4| 9| 2| 3| 3| 9| 4| 0| 3| 3| 3| 3| 3|
| 0| 3| 8| 9| 7| 0| 2| 3| 9| 6| 0| 0| 0| 1| 6| 0| 0| 8| 1| 2| 0| 0| 0| 0| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
5 MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Infiltration Cellular, Focal, | |
Lymphocyte | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Eye | + |
Cataract | 2 |
Retina, Degeneration | 3 |
Sclera, Metaplasia, Osseous | 2 |
__________________________________________________________________________|
Harderian Gland | |
Pigmentation, Porphyrin | |
__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Nephropathy | 3 2 2 2 2 2 3 2 1 2 2 1 2 2 3 2 2 2 3 3 4 3 2|
Pigmentation | 3 |
Pelvis, Epithelium, Hyperplasia, | |
Focal | |
Renal Tubule, Necrosis | 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 1 |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| | |
DAY ON TEST | 0| 3| 0| 8| 6| 3| 3| 9| 5| 2| | |
| 2| 0| 8| 1| 0| 0| 0| 0| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
5 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | L |
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 53 |
Epithelium, Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + M + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + A | 56 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + A A | 54 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A | 52 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A A | 51 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | 2 | 7 2.0|
Basophilic Focus, Focal | | 1 2.0|
Basophilic Focus, Multifocal | | 3 2.0|
Eosinophilic Focus, Focal | | 1 2.0|
Eosinophilic Focus, Multifocal | | 1 2.0|
Fatty Change, Diffuse | | 1 3.0|
Hepatodiaphragmatic Nodule | | 1 |
Leukocytosis | | 3 2.0|
Necrosis, Focal | | 1 2.0|
Bile Duct, Hyperplasia | 3 2 2 2 3 2 2 2 2 2 | 56 2.3|
Centrilobular, Necrosis | 2 2 3 | 5 2.6|
__________________________________________________________________________|____________|
Mesentery | + | 13 |
Inflammation, Focal, Granulomatous | | 1 3.0|
Necrosis, Focal | 4 | 1 4.0|
Fat, Necrosis, Focal | | 10 3.6|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Cytoplasmic Alteration, Multifocal | | 1 2.0|
Acinus, Atrophy | 1 2 | 20 1.8|
Artery, Inflammation, Chronic | | 1 3.0|
Duct, Ectasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + M + + + + | 59 |
Hyperplasia, Focal | | 1 2.0|
Inflammation, Chronic Active | | 1 3.0|
Ulcer | | 2 3.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 60 |
Degeneration, Cystic | 2 1 2 2 2 1 1 1 | 48 1.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| | |
DAY ON TEST | 0| 3| 0| 8| 6| 3| 3| 9| 5| 2| | |
| 2| 0| 8| 1| 0| 0| 0| 0| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
5 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | L |
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Degeneration | | 1 1.0|
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 3 | 1 3.0|
Ulcer | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | | 1 |
Dysplasia | | 1 3.0|
Peridontal Tissue, Inflammation, | | |
Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 2 2 2 | 26 1.9|
Thrombosis | | 1 |
Atrium, Thrombosis | 4 | 4 3.8|
Myocardium, Atrium, Inflammation, | | |
Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Angiectasis | | 2 3.5|
Hyperplasia, Focal | 2 | 6 1.8|
Hypertrophy, Focal | | 1 1.0|
Necrosis, Multifocal | | 1 3.0|
Vacuolization Cytoplasmic, Focal | 1 2 2 1 | 15 1.6|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + M + + M + + + + + | 56 |
Hyperplasia, Focal | 1 | 11 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + M M + + + + | 43 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Cyst | | 3 |
Hemorrhage | | 1 2.0|
Pigmentation, Hemosiderin | | 1 2.0|
Pigmentation, Hemoglobin | | 1 2.0|
Pars Distalis, Hyperplasia, Focal | | 7 2.0|
Pars Nervosa, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| | |
DAY ON TEST | 0| 3| 0| 8| 6| 3| 3| 9| 5| 2| | |
| 2| 0| 8| 1| 0| 0| 0| 0| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
5 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | L |
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 58 |
C-Cell, Hyperplasia | 2 2 | 5 2.0|
Follicle, Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 59 |
Hyperplasia, Focal, Glandular | | 1 3.0|
Inflammation, Chronic Active | 2 2 | 10 2.0|
Duct, Ectasia | | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 4 2.8|
Inflammation, Suppurative | | 1 3.0|
Epithelium, Hyperplasia, Focal | 2 2 | 9 2.0|
Serosa, Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
Atrophy | | 2 3.0|
Inflammation, Chronic Active | 4 | 1 4.0|
Serosa, Inflammation, Suppurative | | 1 3.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Hypospermia | | 7 3.9|
Interstitial Cell, Hyperplasia | 2 | 11 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 56 |
Pigmentation, Hemosiderin | | 1 2.0|
Mediastinal, Hematopoietic Cell | | |
Proliferation | | 1 2.0|
Mediastinal, Hemorrhage | 3 | 9 2.6|
Mediastinal, Pigmentation, | | |
Hemosiderin | | 2 2.0|
Mediastinal, Sinus, Ectasia | | 2 2.5|
Mesenteric, Congestion | | 1 4.0|
Mesenteric, Hemorrhage | 3 | 6 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| | |
DAY ON TEST | 0| 3| 0| 8| 6| 3| 3| 9| 5| 2| | |
| 2| 0| 8| 1| 0| 0| 0| 0| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
5 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | L |
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Mesenteric, Sinus, Ectasia | | 4 2.5|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + M + | 55 |
Hyperplasia, Plasma Cell | 3 3 3 | 7 2.9|
Sinus, Ectasia | 2 2 | 9 2.1|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Ectopic Tissue | X | 2 |
Fibrosis, Diffuse | | 2 3.0|
Fibrosis, Focal | | 5 2.4|
Fibrosis, Multifocal | | 1 3.0|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Hemorrhage | | 1 3.0|
Hyperplasia, Re Cell | | 1 3.0|
Necrosis, Focal | 3 | 1 3.0|
Necrosis, Multifocal | 3 | 1 3.0|
Red Pulp, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + + + M M | 45 |
Cyst | | 1 |
Hemorrhage | | 1 2.0|
Epithelial Cell, Hyperplasia | 1 2 2 2 1 2 2 | 36 1.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + + + + + + | 52 |
Hyperplasia, Nodular | | 1 2.0|
Inflammation, Granulomatous | 2 | 1 2.0|
Duct, Ectasia | 2 | 4 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Hemorrhage | 2 | 2 2.0|
Brain Stem, Compression | | 1 2.0|
Cerebrum, Necrosis | | 1 1.0|
Medulla, Gliosis | | 1 1.0|
Thalamus, Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Peripheral Nerve | M + + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| | |
DAY ON TEST | 0| 3| 0| 8| 6| 3| 3| 9| 5| 2| | |
| 2| 0| 8| 1| 0| 0| 0| 0| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
5 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | L |
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | 4 | 4 2.8|
Hemorrhage | 4 | 5 2.6|
Infiltration Cellular, Histiocyte | 1 1 1 1 | 15 1.1|
Pigmentation | 1 1 1 1 | 15 1.1|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 2 2 | 7 2.0|
Interstitium, Inflammation, Focal | | 1 1.0|
Interstitium, Inflammation | | 1 2.0|
Peribronchiolar, Foreign Body | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Fungus | | 1 4.0|
Hemorrhage | | 2 2.5|
Inflammation, Suppurative | | 3 2.7|
Sinus, Inflammation, Chronic | | 1 2.0|
Sinus, Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
Infiltration Cellular, Focal, | | |
Lymphocyte | | 1 2.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 2 |
__________________________________________________________________________|____________|
Eye | + + | 4 |
Cataract | 3 | 3 2.7|
Retina, Degeneration | 2 3 | 4 2.8|
Sclera, Metaplasia, Osseous | 2 | 2 2.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
Pigmentation, Porphyrin | | 1 3.0|
__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Cyst | | 1 |
Nephropathy | 2 3 2 2 2 2 3 2 3 2 | 57 2.2|
Pigmentation | 4 | 4 3.0|
Pelvis, Epithelium, Hyperplasia, | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 6| 6| 5| | |
DAY ON TEST | 0| 3| 0| 8| 6| 3| 3| 9| 5| 2| | |
| 2| 0| 8| 1| 0| 0| 0| 0| 9| 9| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
5 MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| | L |
LOW MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Focal | | 1 2.0|
Renal Tubule, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 60 |
Infiltration Cellular, Lymphocyte | | 3 1.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 5| 7| 7| 6| 5| 3| 7| 6| 6| 5| 2| 6| 6| 5| 4| 3| 7| 3| 3| 3| 3|
DAY ON TEST | 2| 7| 0| 5| 5| 2| 0| 6| 6| 4| 1| 4| 4| 6| 3| 7| 5| 7| 6| 3| 2| 4| 4| 3| 4|
| 9| 7| 7| 7| 7| 9| 1| 9| 3| 8| 9| 8| 5| 9| 5| 7| 0| 9| 6| 2| 9| 1| 1| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + A + + + A + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + A + + + A + + + + + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + A + + + A + + + + + A +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + M + + + A + + + A + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + A + A + A + + + A + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + A + A + + + A + + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + A + A + + + A + + + + + A +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + A + A + + + A + A + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 2 |
Basophilic Focus, Focal | 2 |
Basophilic Focus | 2 |
Basophilic Focus, Multifocal | 2 |
Congestion | 3 3|
Cytoplasmic Alteration, Focal | |
Fatty Change, Focal | 3 |
Hepatodiaphragmatic Nodule | X X |
Inflammation, Granulomatous, | |
Multifocal | |
Leukocytosis | |
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 1 2 2 2 2 |
Centrilobular, Necrosis | |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Focal, Granulomatous | 4 |
Artery, Inflammation, Chronic | |
Fat, Necrosis, Focal | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 2 2 2 2 4 2 1 2 3 |
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Hyperplasia, Focal | |
Inflammation, Chronic Active | 2|
Ulcer | 3 2|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 1 1 1 1 1 1 1 1 2 2 1 1 |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Inflammation, Chronic Active | |
Mineralization | |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 5| 7| 7| 6| 5| 3| 7| 6| 6| 5| 2| 6| 6| 5| 4| 3| 7| 3| 3| 3| 3|
DAY ON TEST | 2| 7| 0| 5| 5| 2| 0| 6| 6| 4| 1| 4| 4| 6| 3| 7| 5| 7| 6| 3| 2| 4| 4| 3| 4|
| 9| 7| 7| 7| 7| 9| 1| 9| 3| 8| 9| 8| 5| 9| 5| 7| 0| 9| 6| 2| 9| 1| 1| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tongue | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 2 2 2 1 3 1 1 2 2 2 2 2|
Mineralization | |
Artery, Myocardium, Degeneration | 1 |
Atrium, Dilatation | |
Epicardium, Inflammation, Chronic | |
Active, Focal | |
Myocardium, Inflammation, Chronic, | |
Focal | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Hyperplasia, Focal | 1 4 |
Hypertrophy | 2 |
Vacuolization Cytoplasmic, Focal | 2 1 3 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + M + + + + + M + M + + + + M + I|
Hyperplasia, Focal | 1 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | M + + + + + M M + M + + + + + + M M + + M + + M +|
Hyperplasia | |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | X |
Pars Distalis, Hyperplasia, Focal | 2 1 2 2 2 2 2 2 1 |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | X X X |
C-Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Mineralization | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Spermatocele | X |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + M + + M + M M + M|
Cyst | |
Inflammation, Chronic Active | 2 1 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 5| 7| 7| 6| 5| 3| 7| 6| 6| 5| 2| 6| 6| 5| 4| 3| 7| 3| 3| 3| 3|
DAY ON TEST | 2| 7| 0| 5| 5| 2| 0| 6| 6| 4| 1| 4| 4| 6| 3| 7| 5| 7| 6| 3| 2| 4| 4| 3| 4|
| 9| 7| 7| 7| 7| 9| 1| 9| 3| 8| 9| 8| 5| 9| 5| 7| 0| 9| 6| 2| 9| 1| 1| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Suppurative | |
Duct, Ectasia | 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
Inflammation, Suppurative | |
Epithelium, Hyperplasia, Focal | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypospermia | 3 |
Interstitial Cell, Hyperplasia | 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 2 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + M + +|
Lumbar, Hemorrhage | |
Lumbar, Hyperplasia, Plasma Cell | |
Lumbar, Pigmentation, Hemosiderin | |
Mediastinal, Hemorrhage | 2 2 2 3 |
Mediastinal, Hyperplasia, Re Cell | |
Mediastinal, Sinus, Ectasia | |
Mesenteric, Degeneration, Cystic | |
Mesenteric, Hemorrhage | |
Mesenteric, Inflammation, | |
Granulomatous | |
Mesenteric, Sinus, Ectasia | |
Pancreatic, Hemorrhage | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + M + + + M + +|
Congestion | 3 |
Hemorrhage | |
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | 2 |
Sinus, Ectasia | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Necrosis, Focal | 3 |
__________________________________________________________________________|
Thymus | + M + + + + + + + + + + M + + M M + + + + + + + +|
Congestion | 3 |
Hemorrhage | 2 2 2 2 2 |
Epithelial Cell, Hyperplasia | 2 2 2 2 2 2 1 2 2 1 1 1 2 2 2 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + M + + + + + M + + M + + + + M|
Duct, Ectasia | |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 5| 7| 7| 6| 5| 3| 7| 6| 6| 5| 2| 6| 6| 5| 4| 3| 7| 3| 3| 3| 3|
DAY ON TEST | 2| 7| 0| 5| 5| 2| 0| 6| 6| 4| 1| 4| 4| 6| 3| 7| 5| 7| 6| 3| 2| 4| 4| 3| 4|
| 9| 7| 7| 7| 7| 9| 1| 9| 3| 8| 9| 8| 5| 9| 5| 7| 0| 9| 6| 2| 9| 1| 1| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Fat, Necrosis | 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | |
Cranium, Fibrous Osteodystrophy | |
Femur, Fibrous Osteodystrophy | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | 2 2 2 2 |
Cerebrum, Necrosis | 2 2 2 2 3 3 2 2 1 2|
Meninges, Hyperplasia | 2 |
Pons, Necrosis | 2 |
Thalamus, Gliosis | |
Thalamus, Necrosis | 2 2 1 2 2 3 1 3 3 3 3 3 3|
__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + M M + + + M M + + M M M + M M M M|
__________________________________________________________________________|
Spinal Cord | + + + + + + + + M M + + + M M + + M M M + M M M M|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 3 3 3 3 3 3 2 3 3 3 3|
Hemorrhage | 2 4 3 2 2 2 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1|
Necrosis, Focal | |
Pigmentation | 1 1 1 1 1|
Pigmentation, Hemoglobin | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Alveolar Epithelium, Hyperplasia | |
Pleura, Fibrosis, Focal | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 4|
Hemorrhage | 2 |
Inflammation, Suppurative | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
Cataract | 1 |
Retina, Degeneration | |
Sclera, Metaplasia, Osseous | |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 5| 7| 7| 6| 5| 3| 7| 6| 6| 5| 2| 6| 6| 5| 4| 3| 7| 3| 3| 3| 3|
DAY ON TEST | 2| 7| 0| 5| 5| 2| 0| 6| 6| 4| 1| 4| 4| 6| 3| 7| 5| 7| 6| 3| 2| 4| 4| 3| 4|
| 9| 7| 7| 7| 7| 9| 1| 9| 3| 8| 9| 8| 5| 9| 5| 7| 0| 9| 6| 2| 9| 1| 1| 9| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Cyst | |
Nephropathy | 2 3 2 1 2 2 2 3 1 1 2 2 1 2 2 2 2 1 3 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + A +|
Transitional Epithelium, Hyperplasia,| |
Focal | |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 6| 5| 4| 4| 4| 6| 6| 6| 6| 5| 2| 7| 7| 6| 4| 7| 6| 6| 4| 4|
DAY ON TEST | 2| 6| 6| 4| 9| 7| 9| 1| 1| 1| 7| 6| 4| 1| 4| 2| 2| 2| 5| 7| 2| 4| 3| 3| 3|
| 9| 7| 7| 5| 1| 0| 6| 5| 5| 4| 7| 2| 9| 7| 3| 0| 9| 9| 9| 4| 9| 0| 7| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
10MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + A A + M + A + + + + + + + + A + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + A A + + + A + + + + + + + + A + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + A A + + + A + + M + + A + + A + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + A A + + + A + + + + + + + + A + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + A A + + + A A A + + + + + A A + + + + + + A + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 2 2 2 2 |
Basophilic Focus, Focal | 2 2 |
Basophilic Focus | |
Basophilic Focus, Multifocal | 2 |
Congestion | 3 |
Cytoplasmic Alteration, Focal | 2 |
Fatty Change, Focal | |
Hepatodiaphragmatic Nodule | X |
Inflammation, Granulomatous, | |
Multifocal | 1 |
Leukocytosis | 1 |
Bile Duct, Hyperplasia | 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 1|
Centrilobular, Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + + + + |
Inflammation, Focal, Granulomatous | |
Artery, Inflammation, Chronic | 2 |
Fat, Necrosis, Focal | 4 3 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 2 3 2 1 2 2 2 3 2|
Artery, Inflammation, Chronic Active | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Hyperplasia, Focal | |
Inflammation, Chronic Active | |
Ulcer | 3 4 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + A + + + + + + + + +|
Degeneration, Cystic | 2 1 1 3 1 1 1 2 2 1 2 2 2 2 1 |
Infiltration Cellular, Focal, | |
Lymphocyte | |
Inflammation, Chronic Active | 2 |
Mineralization | 4 |
_____________________________________________________________________________________________________________________|
Page 83
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 6| 5| 4| 4| 4| 6| 6| 6| 6| 5| 2| 7| 7| 6| 4| 7| 6| 6| 4| 4|
DAY ON TEST | 2| 6| 6| 4| 9| 7| 9| 1| 1| 1| 7| 6| 4| 1| 4| 2| 2| 2| 5| 7| 2| 4| 3| 3| 3|
| 9| 7| 7| 5| 1| 0| 6| 5| 5| 4| 7| 2| 9| 7| 3| 0| 9| 9| 9| 4| 9| 0| 7| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
10MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
__________________________________________________________________________|
Tongue | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 2 2 2 2 2 2 2 2 1 2 2 |
Mineralization | 2 |
Artery, Myocardium, Degeneration | |
Atrium, Dilatation | 4 |
Epicardium, Inflammation, Chronic | |
Active, Focal | |
Myocardium, Inflammation, Chronic, | |
Focal | 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Hyperplasia, Focal | 2 |
Hypertrophy | |
Vacuolization Cytoplasmic, Focal | 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | M + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 1 2 2 1 2 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M M + M M + M + + + M + M + + + +|
Hyperplasia | 3 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | |
Pars Distalis, Hyperplasia, Focal | 2 2 |
Pars Distalis, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + A + + + + + + + + +|
Ultimobranchial Cyst | X |
C-Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Mineralization | 4 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Spermatocele | |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
Page 84
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 6| 5| 4| 4| 4| 6| 6| 6| 6| 5| 2| 7| 7| 6| 4| 7| 6| 6| 4| 4|
DAY ON TEST | 2| 6| 6| 4| 9| 7| 9| 1| 1| 1| 7| 6| 4| 1| 4| 2| 2| 2| 5| 7| 2| 4| 3| 3| 3|
| 9| 7| 7| 5| 1| 0| 6| 5| 5| 4| 7| 2| 9| 7| 3| 0| 9| 9| 9| 4| 9| 0| 7| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
10MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Inflammation, Suppurative | 2 2 |
Duct, Ectasia | |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Inflammation, Suppurative | 4 |
Epithelium, Hyperplasia, Focal | 2 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypospermia | |
Interstitial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + M + +|
Lumbar, Hemorrhage | 2 1 |
Lumbar, Hyperplasia, Plasma Cell | 2 |
Lumbar, Pigmentation, Hemosiderin | 2 |
Mediastinal, Hemorrhage | 2 2 2 2 |
Mediastinal, Hyperplasia, Re Cell | 2 |
Mediastinal, Sinus, Ectasia | 2 |
Mesenteric, Degeneration, Cystic | |
Mesenteric, Hemorrhage | 2 2 |
Mesenteric, Inflammation, | |
Granulomatous | 1 |
Mesenteric, Sinus, Ectasia | 2 2 2 3|
Pancreatic, Hemorrhage | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + M + M|
Congestion | |
Hemorrhage | 4 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | |
Sinus, Ectasia | 2 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 3 3 2 |
Necrosis, Focal | |
__________________________________________________________________________|
Thymus | + + M + + + + + + M + M + + M + + + + + + + + + +|
Congestion | |
Hemorrhage | |
Epithelial Cell, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + M M + + + + + + M M +|
Duct, Ectasia | 3 2 |
_____________________________________________________________________________________________________________________|
Page 85
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 6| 5| 4| 4| 4| 6| 6| 6| 6| 5| 2| 7| 7| 6| 4| 7| 6| 6| 4| 4|
DAY ON TEST | 2| 6| 6| 4| 9| 7| 9| 1| 1| 1| 7| 6| 4| 1| 4| 2| 2| 2| 5| 7| 2| 4| 3| 3| 3|
| 9| 7| 7| 5| 1| 0| 6| 5| 5| 4| 7| 2| 9| 7| 3| 0| 9| 9| 9| 4| 9| 0| 7| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
10MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
| |
Fat, Necrosis | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + |
Cranium, Fibrous Osteodystrophy | X |
Femur, Fibrous Osteodystrophy | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Hemorrhage | 3 1 |
Cerebrum, Necrosis | 1 3 2 2 2 4 3 2 3 3 4|
Meninges, Hyperplasia | |
Pons, Necrosis | |
Thalamus, Gliosis | 3 |
Thalamus, Necrosis | 3 1 3 4 1 4 2 1 4 2 1 4|
__________________________________________________________________________|
Peripheral Nerve | + + + + M + + + + M + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + + + + M + + + + M + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 2 3 3 4 3 4 2 3 3 4 3 3 4|
Hemorrhage | 1 2 1 2 3 1 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 1 1 1 1 1 1 |
Necrosis, Focal | 2 |
Pigmentation | 1 1 1 1 1 1 1 1 1 1 |
Pigmentation, Hemoglobin | 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 2 |
Alveolar Epithelium, Hyperplasia | |
Pleura, Fibrosis, Focal | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hemorrhage | 1 2 |
Inflammation, Suppurative | 1 2 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + |
Cataract | |
Retina, Degeneration | |
Sclera, Metaplasia, Osseous | |
_____________________________________________________________________________________________________________________|
Page 86
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 6| 5| 4| 4| 4| 6| 6| 6| 6| 5| 2| 7| 7| 6| 4| 7| 6| 6| 4| 4|
DAY ON TEST | 2| 6| 6| 4| 9| 7| 9| 1| 1| 1| 7| 6| 4| 1| 4| 2| 2| 2| 5| 7| 2| 4| 3| 3| 3|
| 9| 7| 7| 5| 1| 0| 6| 5| 5| 4| 7| 2| 9| 7| 3| 0| 9| 9| 9| 4| 9| 0| 7| 2| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
10MG/KG | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Cyst | X |
Nephropathy | 3 2 2 3 2 4 2 1 2 2 2 2 2 2 2 3 2 1 3 3 1 1 1|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia,| |
Focal | 2 |
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 6| 6| 5| 5| 2| | |
DAY ON TEST | 2| 2| 6| 5| 2| 8| 6| 6| 1| 3| | |
| 9| 9| 2| 4| 6| 1| 2| 3| 2| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
10MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Small | + + A + + + + + + + | 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + A + + | 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A A + + + + + + | 48 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + A + + | 44 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | 2 1 | 12 1.9|
Basophilic Focus, Focal | 2 | 4 2.0|
Basophilic Focus | | 1 2.0|
Basophilic Focus, Multifocal | 2 | 3 2.0|
Congestion | | 3 3.0|
Cytoplasmic Alteration, Focal | | 1 2.0|
Fatty Change, Focal | | 1 3.0|
Hepatodiaphragmatic Nodule | X | 4 |
Inflammation, Granulomatous, | | |
Multifocal | | 1 1.0|
Leukocytosis | 2 | 2 1.5|
Bile Duct, Hyperplasia | 2 2 2 2 2 2 2 2 1 | 53 2.0|
Centrilobular, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + | 8 |
Inflammation, Focal, Granulomatous | | 1 4.0|
Artery, Inflammation, Chronic | | 1 2.0|
Fat, Necrosis, Focal | 4 | 5 3.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 60 |
Acinus, Atrophy | 3 3 2 | 22 2.2|
Artery, Inflammation, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
Acinus, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
Erosion | 3 2 | 3 2.3|
Hyperplasia, Focal | 2 | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
Ulcer | | 5 3.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 6| 6| 5| 5| 2| | |
DAY ON TEST | 2| 2| 6| 5| 2| 8| 6| 6| 1| 3| | |
| 9| 9| 2| 4| 6| 1| 2| 3| 2| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
10MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Degeneration, Cystic | 2 1 1 1 1 1 1 | 35 1.4|
Infiltration Cellular, Focal, | | |
Lymphocyte | 3 | 1 3.0|
Inflammation, Chronic Active | | 1 2.0|
Mineralization | | 1 4.0|
__________________________________________________________________________|____________|
Tongue | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | 2 2 2 2 2 1 1 | 36 1.8|
Mineralization | | 1 2.0|
Artery, Myocardium, Degeneration | | 1 1.0|
Atrium, Dilatation | | 1 4.0|
Epicardium, Inflammation, Chronic | | |
Active, Focal | 2 | 1 2.0|
Myocardium, Inflammation, Chronic, | | |
Focal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + | 60 |
Accessory Adrenal Cortical Nodule | | 1 |
Hyperplasia, Focal | 2 3 | 5 2.4|
Hypertrophy | | 1 2.0|
Vacuolization Cytoplasmic, Focal | 1 1 | 8 1.8|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + | 53 |
Hyperplasia, Focal | 1 | 11 1.5|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M M + | 43 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 60 |
Angiectasis | | 1 2.0|
Cyst | X | 2 |
Pars Distalis, Hyperplasia, Focal | 2 | 12 1.8|
Pars Distalis, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Ultimobranchial Cyst | | 4 |
C-Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 6| 6| 5| 5| 2| | |
DAY ON TEST | 2| 2| 6| 5| 2| 8| 6| 6| 1| 3| | |
| 9| 9| 2| 4| 6| 1| 2| 3| 2| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
10MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Mineralization | | 1 4.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 60 |
Spermatocele | | 1 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 55 |
Cyst | | 1 |
Inflammation, Chronic Active | 2 2 3 | 11 2.0|
Inflammation, Suppurative | | 2 2.0|
Duct, Ectasia | | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 60 |
Inflammation, Chronic Active | | 1 3.0|
Inflammation, Suppurative | | 1 4.0|
Epithelium, Hyperplasia, Focal | 2 | 3 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 60 |
Hypospermia | | 1 3.0|
Interstitial Cell, Hyperplasia | 2 2 2 | 17 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Atrophy | | 3 2.7|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + | 58 |
Lumbar, Hemorrhage | | 2 1.5|
Lumbar, Hyperplasia, Plasma Cell | | 1 2.0|
Lumbar, Pigmentation, Hemosiderin | | 1 2.0|
Mediastinal, Hemorrhage | 2 3 2 2 3 | 13 2.2|
Mediastinal, Hyperplasia, Re Cell | | 1 2.0|
Mediastinal, Sinus, Ectasia | | 1 2.0|
Mesenteric, Degeneration, Cystic | 3 | 1 3.0|
Mesenteric, Hemorrhage | 3 | 3 2.3|
Mesenteric, Inflammation, | | |
Granulomatous | | 1 1.0|
Mesenteric, Sinus, Ectasia | 3 | 5 2.4|
Pancreatic, Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M + + + | 55 |
Congestion | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 6| 6| 5| 5| 2| | |
DAY ON TEST | 2| 2| 6| 5| 2| 8| 6| 6| 1| 3| | |
| 9| 9| 2| 4| 6| 1| 2| 3| 2| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
10MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hemorrhage | | 1 4.0|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Plasma Cell | | 1 2.0|
Sinus, Ectasia | | 4 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Fibrosis, Focal | 3 | 4 2.8|
Necrosis, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | M + M M + + + + + + | 49 |
Congestion | | 1 3.0|
Hemorrhage | | 5 2.0|
Epithelial Cell, Hyperplasia | 2 1 1 2 2 1 | 40 1.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + M + + + + + + + + | 50 |
Duct, Ectasia | | 2 2.5|
Fat, Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
Abscess | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | | 2 |
Cranium, Fibrous Osteodystrophy | | 1 |
Femur, Fibrous Osteodystrophy | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
Congestion | | 2 2.0|
Hemorrhage | | 6 2.0|
Cerebrum, Necrosis | 2 3 1 | 24 2.3|
Meninges, Hyperplasia | | 1 2.0|
Pons, Necrosis | | 1 2.0|
Thalamus, Gliosis | | 1 3.0|
Thalamus, Necrosis | | 25 2.4|
__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + | 47 |
__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + | 47 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 60 |
Congestion | 3 3 2 4 | 30 3.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 05026-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC SODIUM AZIDE Date: 04/29/97
Route: GAVAGE Time: 17:43:14
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 6| 5| 6| 6| 5| 5| 2| | |
DAY ON TEST | 2| 2| 6| 5| 2| 8| 6| 6| 1| 3| | |
| 9| 9| 2| 4| 6| 1| 2| 3| 2| 3| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
10MG/KG | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | L |
HIGHMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Hemorrhage | 2 2 4 | 17 2.2|
Infiltration Cellular, Histiocyte | 1 1 1 1 | 21 1.0|
Necrosis, Focal | | 1 2.0|
Pigmentation | 1 1 1 1 | 19 1.0|
Pigmentation, Hemoglobin | | 1 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 | 4 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 1 2.0|
Pleura, Fibrosis, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 60 |
Congestion | | 3 3.3|
Hemorrhage | 2 | 4 1.8|
Inflammation, Suppurative | | 3 1.3|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 4 |
Cataract | 4 | 2 2.5|
Retina, Degeneration | 3 | 1 3.0|
Sclera, Metaplasia, Osseous | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Congestion | | 1 3.0|
Cyst | | 1 |
Nephropathy | 2 2 2 1 1 1 2 2 2 1 | 53 1.9|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Transitional Epithelium, Hyperplasia,| | |
Focal | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
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