National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3482

TR 391 Mouse Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                   TRIS (2-CHLOROETHYL) PHOSPHATE


NTP Experiment-Test: 05042-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/05/94
Route: GAVAGE                                                                                                     Time: 16:28:50




       Facility:  Microbiological Associates

       Chemical CAS #:  115-96-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05042-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 16:28:50  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      175MG/KG     350MG/KG                                               
                                                   FEMALE       LOW FEM       HIGHFEM                                               
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Scheduled Sacrifice                                  9           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                           7            5            5                                                  
    Dead                                               6            6            8                                                  
    Gavage Death                                       5            2            2                                                  
    Accident                                           1                                                                            
    Dosing Accident                                    1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                31           37           35                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (13)         (49)                                                
      Periesophageal Tissue, Foreign Body              1 (2%)                                                                       
      Periesophageal Tissue, Inflammation, Acute       3 (6%)                                                                       
      Wall, Inflammation, Necrotizing                  1 (2%)                                                                       
   Intestine Small, Ileum                             (43)         (9)          (46)                                                
      Hyperplasia, Lymphoid                            2 (5%)                                                                       
   Intestine Small, Jejunum                           (45)         (12)         (46)                                                
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis                                                   1 (2%)                                                          
      Clear Cell Focus                                                           1 (2%)                                             
      Eosinophilic Focus                               1 (2%)       3 (6%)       1 (2%)                                             
      Hematopoietic Cell Proliferation                 1 (2%)       1 (2%)       3 (6%)                                             
      Inflammation, Chronic                            1 (2%)       1 (2%)       1 (2%)                                             
      Inflammation, Subacute                                                     2 (4%)                                             
      Necrosis, Coagulative                                         3 (6%)       4 (8%)                                             
      Vacuolization Cytoplasmic                        3 (6%)       4 (8%)       1 (2%)                                             
   Mesentery                                          (7)          (9)          (9)                                                 
      Infiltration Cellular, Mast Cell                 1 (14%)                                                                      
      Fat, Necrosis                                    3 (43%)      8 (89%)      8 (89%)                                            
   Pancreas                                           (49)         (13)         (48)                                                
      Inflammation, Chronic                                                      1 (2%)                                             
      Acinus, Atrophy                                  4 (8%)       2 (15%)      6 (13%)                                            
      Acinus, Basophilic Focus                         1 (2%)       1 (8%)       1 (2%)                                             
      Acinus, Necrosis, Coagulative                    1 (2%)                                                                       
      Duct, Ectasia                                                 1 (8%)                                                          
   Salivary Glands                                    (50)         (13)         (48)                                                
      Inflammation, Chronic                            8 (16%)      1 (8%)       5 (10%)                                            
   Stomach, Forestomach                               (49)         (49)         (48)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05042-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 16:28:50  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      175MG/KG     350MG/KG                                               
                                                   FEMALE       LOW FEM       HIGHFEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hyperplasia, Squamous                            4 (8%)       1 (2%)       8 (17%)                                            
      Infiltration Cellular, Mast Cell                 1 (2%)                                                                       
      Inflammation, Acute                              1 (2%)                                                                       
   Stomach, Glandular                                 (48)         (49)         (47)                                                
      Infiltration Cellular, Mast Cell                 1 (2%)                                                                       
      Mucosa, Dilatation                               1 (2%)                    1 (2%)                                             
      Mucosa, Hyperplasia                              1 (2%)                                                                       
   Tooth                                              (49)         (13)         (50)                                                
      Inflammation, Acute                              2 (4%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (13)         (49)                                                
      Inflammation, Chronic                                         1 (8%)                                                          
      Inflammation, Subacute                                                     1 (2%)                                             
      Atrium, Thrombosis                                            1 (8%)                                                          
      Epicardium, Inflammation, Acute                  4 (8%)       1 (8%)                                                          
      Myocardium, Necrosis, Zenkers                                              1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (12)         (50)                                                
      Atrophy                                          1 (2%)                                                                       
      Degeneration, Ballooning                         1 (2%)                    1 (2%)                                             
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hypertrophy, Focal                               1 (2%)                                                                       
   Adrenal Gland, Medulla                             (49)         (12)         (48)                                                
      Hyperplasia                                      2 (4%)                                                                       
   Pituitary Gland                                    (48)         (14)         (44)                                                
      Pars Distalis, Angiectasis                       4 (8%)                    4 (9%)                                             
      Pars Distalis, Hyperplasia                       6 (13%)      1 (7%)       5 (11%)                                            
      Pars Distalis, Hypertrophy, Focal                1 (2%)                                                                       
   Thyroid Gland                                      (50)         (12)         (49)                                                
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic                            2 (4%)                                                                       
      Follicle, Cyst                                                1 (8%)                                                          
      Follicular Cell, Hyperplasia                     6 (12%)                   6 (12%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05042-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 16:28:50  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      175MG/KG     350MG/KG                                               
                                                   FEMALE       LOW FEM       HIGHFEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (37)         (16)         (35)                                                
      Cyst                                            14 (38%)      6 (38%)      7 (20%)                                            
      Periovarian Tissue, Inflammation, Chronic                                  1 (3%)                                             
   Uterus                                             (50)         (43)         (50)                                                
      Hydrometra                                                    1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)                                                                       
      Endometrium, Hyperplasia, Cystic                49 (98%)     42 (98%)     48 (96%)                                            
      Endometrium, Inflammation, Acute                              2 (5%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (13)         (50)                                                
      Hyperplasia, Reticulum Cell                                                1 (2%)                                             
      Myelofibrosis                                   12 (24%)                  14 (28%)                                            
   Lymph Node                                         (49)         (17)         (50)                                                
      Iliac, Hemorrhage                                1 (2%)                                                                       
      Iliac, Hyperplasia, Plasma Cell                  1 (2%)                                                                       
      Inguinal, Infiltration Cellular, Mast Cell       1 (2%)                                                                       
      Mediastinal, Hyperplasia, Lymphoid                            1 (6%)       1 (2%)                                             
   Lymph Node, Mandibular                             (47)         (12)         (47)                                                
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hyperplasia, Lymphoid                                                      2 (4%)                                             
      Hyperplasia, Plasma Cell                         1 (2%)                                                                       
      Infiltration Cellular, Mast Cell                 1 (2%)                                                                       
   Lymph Node, Mesenteric                             (45)         (16)         (48)                                                
      Ectasia                                          1 (2%)                                                                       
      Hematopoietic Cell Proliferation                              1 (6%)       1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)                    3 (6%)                                             
      Inflammation, Chronic                                         1 (6%)                                                          
   Spleen                                             (50)         (20)         (48)                                                
      Atrophy                                          1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 2 (4%)       5 (25%)      5 (10%)                                            
      Hyperplasia, Lymphoid                            2 (4%)       3 (15%)      6 (13%)                                            
      Hyperplasia, Plasma Cell                         1 (2%)                                                                       
   Thymus                                             (45)         (8)          (40)                                                
      Cyst                                             1 (2%)                    3 (8%)                                             
      Hyperplasia, Lymphoid                            1 (2%)                    1 (3%)                                             
      Mediastinum, Foreign Body                        1 (2%)                                                                       
      Mediastinum, Inflammation, Acute                 3 (7%)       1 (13%)                                                         
      Thymocyte, Necrosis                              1 (2%)       1 (13%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05042-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 16:28:50  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      175MG/KG     350MG/KG                                               
                                                   FEMALE       LOW FEM       HIGHFEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (33)         (45)                                                
      Hyperplasia, Cystic                              3 (6%)       3 (9%)       5 (11%)                                            
      Duct, Ectasia                                                              1 (2%)                                             
      Duct, Hyperplasia                                             1 (3%)       1 (2%)                                             
   Skin                                               (50)         (48)         (50)                                                
      Fibrosis                                                      1 (2%)                                                          
      Foreign Body                                     1 (2%)                                                                       
      Inflammation, Acute                              1 (2%)       3 (6%)                                                          
      Inflammation, Chronic                            1 (2%)                    2 (4%)                                             
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Face, Inflammation, Acute                                                  2 (4%)                                             
      Subcutaneous Tissue, Abscess                     2 (4%)                                                                       
      Subcutaneous Tissue, Necrosis                                 1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (49)         (14)         (50)                                                
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Chronic                                                      1 (2%)                                             
      Head, Inflammation, Acute                        1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (13)         (49)                                                
      Hemorrhage                                       1 (2%)                                                                       
      Necrosis, Liquifactive                                        1 (8%)                                                          
      Meninges, Inflammation, Chronic                  1 (2%)                    1 (2%)                                             
      Thalamus, Inflammation                           1 (2%)                                                                       
      Thalamus, Mineralization                        21 (42%)      6 (46%)     23 (47%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (49)                                                
      Congestion                                       2 (4%)       1 (2%)       1 (2%)                                             
      Foreign Body                                     1 (2%)       1 (2%)                                                          
      Hemorrhage                                       2 (4%)                                                                       
      Inflammation, Acute                              1 (2%)                    1 (2%)                                             
      Inflammation, Chronic                            2 (4%)       4 (8%)       2 (4%)                                             
      Leukocytosis                                                               1 (2%)                                             
      Thrombosis                                                                 1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                              2 (4%)       3 (6%)                                             
      Alveolus, Foreign Body                                        3 (6%)                                                          
      Alveolus, Infiltration Cellular, Histiocyte      1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05042-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 16:28:50  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      175MG/KG     350MG/KG                                               
                                                   FEMALE       LOW FEM       HIGHFEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Arteriole, Hyperplasia                                                     1 (2%)                                             
      Fat, Mediastinum, Necrosis                                    1 (2%)                                                          
      Mediastinum, Foreign Body                        4 (8%)       1 (2%)       3 (6%)                                             
      Mediastinum, Inflammation, Acute                 2 (4%)       1 (2%)       2 (4%)                                             
      Mediastinum, Inflammation, Chronic                                         1 (2%)                                             
      Pleura, Inflammation, Acute                      2 (4%)       1 (2%)                                                          
   Nose                                               (49)         (14)         (50)                                                
      Infiltration Cellular, Mast Cell                 1 (2%)                                                                       
      Inflammation, Acute                              1 (2%)                                                                       
      Nasolacrimal Duct, Foreign Body                                            1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Acute                        1 (7%)       1 (2%)                                             
      Respiratory Epithelium, Inflammation, Acute      1 (2%)                                                                       
   Trachea                                            (50)         (12)         (50)                                                
      Glands, Dilatation                                                         1 (2%)                                             
      Peritracheal Tissue, Foreign Body                2 (4%)       1 (8%)                                                          
      Peritracheal Tissue, Inflammation, Acute         2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (49)         (49)         (49)                                                
      Hyperplasia                                      1 (2%)       4 (8%)       2 (4%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (50)                                                
      Infarct                                                       3 (6%)       2 (4%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Metaplasia, Osseous                              1 (2%)       1 (2%)       1 (2%)                                             
      Mineralization                                                1 (2%)                                                          
      Nephropathy                                      8 (16%)      1 (2%)       9 (18%)                                            
      Cortex, Necrosis, Coagulative                                              1 (2%)                                             
      Glomerulus, Amyloid Deposition                   1 (2%)                                                                       
      Medulla, Inflammation, Acute                                  1 (2%)                                                          
      Renal Tubule, Karyomegaly                                     5 (10%)     44 (88%)                                            
   Urinary Bladder                                    (49)         (12)         (49)                                                
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05042-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 16:28:50  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      175MG/KG     350MG/KG                                               
                                                   MALE         LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Scheduled Sacrifice                                  8           10            8                                                  
  Early Deaths                                                                                                                      
    Moribund                                          10            8           12                                                  
    Dead                                              14           13            9                                                  
    Dosing Accident                                    1            1            2                                                  
    Gavage Death                                       2            3            3                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                25           25           25                                                  
  Missing                                                                        1                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (48)         (23)         (50)                                                
      Perforation                                      1 (2%)                                                                       
      Periesophageal Tissue, Foreign Body              1 (2%)       3 (13%)      1 (2%)                                             
      Periesophageal Tissue, Inflammation, Acute       3 (6%)       3 (13%)      1 (2%)                                             
      Periesophageal Tissue, Inflammation, Chronic                  2 (9%)                                                          
      Periesophageal Tissue, Inflammation,                                                                                          
          Granulomatous                                1 (2%)       1 (4%)                                                          
   Intestine Large, Cecum                             (47)         (25)         (46)                                                
      Inflammation, Acute                                                        1 (2%)                                             
   Intestine Large, Colon                             (49)         (26)         (47)                                                
      Inflammation, Acute                                           1 (4%)                                                          
   Intestine Small, Duodenum                          (16)         (7)          (11)                                                
      Inflammation, Chronic                                         1 (14%)                                                         
      Inflammation, Necrotizing                                                  1 (9%)                                             
   Intestine Small, Ileum                             (43)         (23)         (41)                                                
      Hyperplasia, Lymphoid                                         1 (4%)                                                          
   Intestine Small, Jejunum                           (45)         (23)         (44)                                                
      Ulcer                                                                      1 (2%)                                             
   Liver                                              (50)         (50)         (50)                                                
      Amyloid Deposition                                            1 (2%)                                                          
      Angiectasis                                                                2 (4%)                                             
      Basophilic Focus                                 1 (2%)       2 (4%)       1 (2%)                                             
      Clear Cell Focus                                 4 (8%)       1 (2%)       5 (10%)                                            
      Cytomegaly                                                                 1 (2%)                                             
      Eosinophilic Focus                                            3 (6%)       8 (16%)                                            
      Hematopoietic Cell Proliferation                 2 (4%)       1 (2%)                                                          
      Hyperplasia, Chronic, Lymphoid                                1 (2%)                                                          
      Inflammation, Subacute                           1 (2%)                                                                       
      Mitotic Alteration                                                         1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05042-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 16:28:50  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      175MG/KG     350MG/KG                                               
                                                   MALE         LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Mixed Cell Focus                                              2 (4%)       1 (2%)                                             
      Necrosis, Coagulative                            2 (4%)       4 (8%)       4 (8%)                                             
      Vacuolization Cytoplasmic                        4 (8%)       2 (4%)       4 (8%)                                             
   Mesentery                                          (9)          (2)          (4)                                                 
      Hemorrhage                                                                 1 (25%)                                            
      Inflammation, Acute                              1 (11%)                                                                      
      Fat, Necrosis                                    5 (56%)      2 (100%)     1 (25%)                                            
   Pancreas                                           (49)         (26)         (49)                                                
      Inflammation, Acute                              1 (2%)                                                                       
      Acinus, Atrophy                                 10 (20%)      3 (12%)      8 (16%)                                            
      Acinus, Basophilic Focus                                                   1 (2%)                                             
      Acinus, Hyperplasia                                                        1 (2%)                                             
      Acinus, Vacuolization Cytoplasmic                1 (2%)                    1 (2%)                                             
   Salivary Glands                                    (49)         (24)         (49)                                                
      Inflammation, Chronic                            8 (16%)      1 (4%)      13 (27%)                                            
   Stomach, Forestomach                               (49)         (50)         (49)                                                
      Hyperplasia                                                   1 (2%)                                                          
      Hyperplasia, Squamous                            2 (4%)       3 (6%)       6 (12%)                                            
      Infiltration Cellular, Mast Cell                              1 (2%)                                                          
      Inflammation, Acute                                           2 (4%)                                                          
      Ulcer                                                         1 (2%)                                                          
   Stomach, Glandular                                 (50)         (47)         (47)                                                
      Inflammation, Acute                              2 (4%)                    2 (4%)                                             
      Mucosa, Dilatation                               1 (2%)       1 (2%)       1 (2%)                                             
   Tooth                                              (50)         (25)         (49)                                                
      Dysplasia                                       21 (42%)      6 (24%)     18 (37%)                                            
      Inflammation, Acute                              3 (6%)                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (25)         (50)                                                
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Subacute                           1 (2%)                    2 (4%)                                             
      Mineralization                                                1 (4%)                                                          
      Atrium, Thrombosis                               1 (2%)       1 (4%)       2 (4%)                                             
      Myocardium, Degeneration                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (48)         (23)         (48)                                                
      Atrophy                                          1 (2%)                    4 (8%)                                             
      Degeneration, Ballooning                         4 (8%)                                                                       
      Hyperplasia                                      1 (2%)                                                                       
      Hyperplasia, Focal                               1 (2%)       1 (4%)                                                          
      Hypertrophy                                      1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05042-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 16:28:50  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      175MG/KG     350MG/KG                                               
                                                   MALE         LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hypertrophy, Focal                                                         2 (4%)                                             
      Spindle Cell, Hyperplasia                                     1 (4%)                                                          
   Adrenal Gland, Medulla                             (46)         (23)         (43)                                                
      Hyperplasia                                                   1 (4%)       1 (2%)                                             
   Pituitary Gland                                    (45)         (22)         (48)                                                
      Pars Distalis, Cyst                              1 (2%)                                                                       
   Thyroid Gland                                      (49)         (23)         (49)                                                
      Inflammation, Acute                              1 (2%)                                                                       
      Ultimobranchial Cyst                                          1 (4%)       1 (2%)                                             
      Follicle, Cyst                                                1 (4%)                                                          
      Follicular Cell, Hyperplasia                     3 (6%)                    6 (12%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (7)          (3)          (5)                                                 
      Inflammation, Chronic                            6 (86%)                   2 (40%)                                            
   Prostate                                           (49)         (23)         (47)                                                
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
   Seminal Vesicle                                    (48)         (26)         (50)                                                
      Concretion                                                    1 (4%)                                                          
      Inflammation, Chronic                            1 (2%)                                                                       
   Testes                                             (50)         (24)         (50)                                                
      Interstitial Cell, Hyperplasia                   2 (4%)                                                                       
      Seminiferous Tubule, Atrophy                                  1 (4%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (25)         (49)                                                
      Atrophy                                          2 (4%)                                                                       
   Lymph Node                                         (50)         (27)         (49)                                                
      Mediastinal, Inflammation, Acute                              1 (4%)                                                          
      Renal, Hyperplasia, Lymphoid                                               1 (2%)                                             
   Lymph Node, Mandibular                             (46)         (22)         (44)                                                
      Infiltration Cellular, Plasma Cell                                         1 (2%)                                             
   Lymph Node, Mesenteric                             (48)         (24)         (44)                                                
      Angiectasis                                                                1 (2%)                                             
      Hyperplasia, Lymphoid                                         1 (4%)                                                          
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic                                         1 (4%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05042-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 16:28:50  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      175MG/KG     350MG/KG                                               
                                                   MALE         LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Thrombosis                                       1 (2%)                                                                       
   Spleen                                             (50)         (28)         (49)                                                
      Amyloid Deposition                                            1 (4%)                                                          
      Angiectasis                                                                1 (2%)                                             
      Atrophy                                                                    3 (6%)                                             
      Hematopoietic Cell Proliferation                 3 (6%)       4 (14%)      2 (4%)                                             
      Hyperplasia, Lymphoid                            2 (4%)       2 (7%)       1 (2%)                                             
   Thymus                                             (29)         (17)         (33)                                                
      Cyst                                             3 (10%)                   2 (6%)                                             
      Thymocyte, Necrosis                                           3 (18%)      1 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (35)         (49)                                                
      Acanthosis                                       1 (2%)       1 (3%)       1 (2%)                                             
      Edema                                            1 (2%)                                                                       
      Fibrosis                                         1 (2%)                                                                       
      Hyperplasia, Basal Cell                                                    1 (2%)                                             
      Inflammation                                     1 (2%)                    1 (2%)                                             
      Inflammation, Acute                              2 (4%)       2 (6%)       2 (4%)                                             
      Inflammation, Chronic                            1 (2%)       1 (3%)       4 (8%)                                             
      Pigmentation                                     1 (2%)                                                                       
      Face, Foreign Body                               1 (2%)                                                                       
      Face, Inflammation, Acute                        1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Abscess                     1 (2%)       2 (6%)       2 (4%)                                             
      Subcutaneous Tissue, Foreign Body                             1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (25)         (49)                                                
      Fracture Healed                                  1 (2%)                                                                       
      Tibia, Hyperostosis                                           1 (4%)                                                          
   Skeletal Muscle                                    (50)         (25)         (50)                                                
      Fibrosis                                         1 (2%)                                                                       
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Head, Inflammation, Acute                                                  2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (25)         (50)                                                
      Meninges, Inflammation, Chronic                  1 (2%)                                                                       
      Thalamus, Mineralization                        17 (34%)     14 (56%)     26 (52%)                                            
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05042-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 16:28:50  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      175MG/KG     350MG/KG                                               
                                                   MALE         LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Congestion                                       3 (6%)       1 (2%)       2 (4%)                                             
      Edema                                            1 (2%)                                                                       
      Foreign Body                                     2 (4%)                    3 (6%)                                             
      Hemorrhage                                                    1 (2%)       1 (2%)                                             
      Inflammation, Acute                                           1 (2%)                                                          
      Inflammation, Chronic                            3 (6%)       1 (2%)       3 (6%)                                             
      Leukocytosis                                                               1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 4 (8%)       3 (6%)       3 (6%)                                             
      Alveolus, Foreign Body                           3 (6%)                                                                       
      Alveolus, Infiltration Cellular                  1 (2%)                                                                       
      Alveolus, Infiltration Cellular, Histiocyte      2 (4%)       5 (10%)      3 (6%)                                             
      Mediastinum, Foreign Body                        5 (10%)      2 (4%)       3 (6%)                                             
      Mediastinum, Inflammation, Acute                 5 (10%)      2 (4%)       5 (10%)                                            
      Pleura, Foreign Body                             1 (2%)                                                                       
      Pleura, Inflammation, Acute                      3 (6%)       2 (4%)                                                          
      Pleura, Inflammation, Granulomatous              2 (4%)                    1 (2%)                                             
   Nose                                               (50)         (25)         (50)                                                
      Foreign Body                                     1 (2%)       1 (4%)                                                          
      Inflammation, Acute                                                        1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Subacute                                  1 (2%)                                             
   Trachea                                            (49)         (24)         (49)                                                
      Peritracheal Tissue, Inflammation, Acute         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (2)          (1)          (1)                                                 
      Inflammation, Acute                                           1 (100%)                                                        
      Middle Ear, Inflammation, Acute                  1 (50%)                                                                      
      Pinna, Hyperplasia                                                         1 (100%)                                           
   Eye                                                (6)          (5)          (7)                                                 
      Lens, Cataract                                                1 (20%)      1 (14%)                                            
   Harderian Gland                                    (48)         (49)         (47)                                                
      Hyperplasia                                      3 (6%)       3 (6%)       5 (11%)                                            
      Inflammation, Chronic                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Amyloid Deposition                                            1 (2%)                                                          
      Infarct                                          1 (2%)       2 (4%)                                                          
      Inflammation, Chronic                                                      1 (2%)                                             
      Metaplasia, Osseous                              2 (4%)       5 (10%)      3 (6%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05042-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 16:28:50  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      175MG/KG     350MG/KG                                               
                                                   MALE         LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Nephropathy                                      9 (18%)      7 (14%)     13 (26%)                                            
      Glomerulus, Dilatation                           1 (2%)                    1 (2%)                                             
      Pelvis, Inflammation, Acute                      3 (6%)                    1 (2%)                                             
      Proximal Convoluted Renal Tubule, Dilatation                               2 (4%)                                             
      Renal Tubule, Hyperplasia                                                  1 (2%)                                             
      Renal Tubule, Karyomegaly                        2 (4%)      16 (32%)     39 (78%)                                            
      Renal Tubule, Necrosis, Coagulative              1 (2%)                                                                       
      Renal Tubule, Pigmentation                                                 1 (2%)                                             
   Urinary Bladder                                    (50)         (24)         (49)                                                
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Acute                              2 (4%)                    1 (2%)                                             
      Inflammation, Chronic                            2 (4%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.