National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3486

TR 391 Mouse Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                   TRIS (2-CHLOROETHYL) PHOSPHATE


NTP Experiment-Test: 05042-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/05/94
Route: GAVAGE                                                                                                     Time: 16:28:52




       Facility:  Microbiological Associates

       Chemical CAS #:  115-96-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05042-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 16:28:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      175MG/KG     350MG/KG                                               
                                                   FEMALE       LOW FEM       HIGHFEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Scheduled Sacrifice                                  9           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                           7            5            5                                                  
    Dead                                               6            6            8                                                  
    Gavage Death                                       5            2            2                                                  
    Accident                                           1                                                                            
    Dosing Accident                                    1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                31           37           35                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (41)         (8)          (43)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Intestine Large, Cecum                             (49)         (10)         (49)                                                
   Liver                                              (50)         (50)         (50)                                                
      Hepatocellular Carcinoma                         2 (4%)       2 (4%)       3 (6%)                                             
      Hepatocellular Adenoma                           3 (6%)       2 (4%)       4 (8%)                                             
      Hepatocellular Adenoma, Multiple                              1 (2%)       1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Mesentery                                          (7)          (9)          (9)                                                 
      Fibrosarcoma, Metastatic, Skin                                             1 (11%)                                            
      Hemangiosarcoma, Metastatic, Skeletal Muscle                  1 (11%)                                                         
   Pancreas                                           (49)         (13)         (48)                                                
      Fibrosarcoma, Metastatic, Skin                                1 (8%)                                                          
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Salivary Glands                                    (50)         (13)         (48)                                                
      Mast Cell Tumor Malignant, Metastatic, Spleen                 1 (8%)                                                          
   Stomach, Forestomach                               (49)         (49)         (48)                                                
      Squamous Cell Papilloma                          1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (13)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05042-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 16:28:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      175MG/KG     350MG/KG                                               
                                                   FEMALE       LOW FEM       HIGHFEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)         (12)         (50)                                                
   Adrenal Gland, Cortex                              (49)         (12)         (50)                                                
   Adrenal Gland, Medulla                             (49)         (12)         (48)                                                
      Pheochromocytoma Benign                                                    1 (2%)                                             
   Pituitary Gland                                    (48)         (14)         (44)                                                
      Pars Distalis, Adenoma                           4 (8%)       3 (21%)      1 (2%)                                             
   Thyroid Gland                                      (50)         (12)         (49)                                                
      Follicular Cell, Adenoma                                      1 (8%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (37)         (16)         (35)                                                
      Cystadenoma                                                   1 (6%)                                                          
   Uterus                                             (50)         (43)         (50)                                                
      Deciduoma Benign                                              1 (2%)                                                          
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Cervix, Hemangiosarcoma                                                    1 (2%)                                             
      Endometrium, Adenocarcinoma                                                1 (2%)                                             
      Endometrium, Polyp Stromal                                    1 (2%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (13)         (50)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Mast Cell Tumor Malignant                                                  1 (2%)                                             
   Lymph Node                                         (49)         (17)         (50)                                                
   Lymph Node, Mandibular                             (47)         (12)         (47)                                                
      Fibrosarcoma, Metastatic, Ear                                              1 (2%)                                             
      Mast Cell Tumor Malignant                                                  1 (2%)                                             
   Lymph Node, Mesenteric                             (45)         (16)         (48)                                                
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                                             
      Mast Cell Tumor Malignant, Metastatic, Spleen                 1 (6%)                                                          
   Spleen                                             (50)         (20)         (48)                                                
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
      Hemangiosarcoma                                               1 (5%)                                                          
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Mast Cell Tumor Malignant                                     1 (5%)                                                          
   Thymus                                             (45)         (8)          (40)                                                
      Mast Cell Tumor Malignant                                                  1 (3%)                                             
                                                             Page   3                                                               
NTP Experiment-Test: 05042-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 16:28:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      175MG/KG     350MG/KG                                               
                                                   FEMALE       LOW FEM       HIGHFEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (33)         (45)                                                
      Adenocarcinoma                                                             3 (7%)                                             
      Fibroadenoma                                     1 (2%)                                                                       
   Skin                                               (50)         (48)         (50)                                                
      Mast Cell Tumor Malignant, Metastatic, Spleen                 1 (2%)                                                          
      Trichoepithelioma                                             1 (2%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)       2 (4%)                                             
      Subcutaneous Tissue, Fibrosarcoma, Multiple                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (49)         (14)         (50)                                                
      Hemangiosarcoma                                               1 (7%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (13)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (49)                                                
      Alveolar/Bronchiolar Adenoma                     2 (4%)       2 (4%)       5 (10%)                                            
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Skin                                1 (2%)       1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      2 (4%)                    1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                                             
      Squamous Cell Carcinoma, Metastatic, Ear         1 (2%)                    1 (2%)                                             
   Nose                                               (49)         (14)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (2)                       (3)                                                 
      Fibrosarcoma                                                               1 (33%)                                            
      Squamous Cell Carcinoma                                                    1 (33%)                                            
      External Ear, Squamous Cell Carcinoma            1 (50%)                                                                      
      Pinna, Fibrosarcoma                                                        1 (33%)                                            
   Harderian Gland                                    (49)         (49)         (49)                                                
      Adenoma                                          3 (6%)       6 (12%)      7 (14%)                                            
      Adenoma, Multiple                                             1 (2%)                                                          
      Carcinoma                                                     1 (2%)                                                          
                                                             Page   4                                                               
NTP Experiment-Test: 05042-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 16:28:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      175MG/KG     350MG/KG                                               
                                                   FEMALE       LOW FEM       HIGHFEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
SPECIAL SENSES SYSTEM - cont                                                                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (50)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Renal Tubule, Adenoma                                         1 (2%)                                                          
   Urinary Bladder                                    (49)         (12)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Histiocytic Sarcoma                              1 (2%)                    2 (4%)                                             
      Leukemia                                                      1 (2%)                                                          
      Lymphoma Malignant Lymphocytic                   3 (6%)       2 (4%)                                                          
      Lymphoma Malignant Mixed                         7 (14%)      5 (10%)      3 (6%)                                             
      Mesothelioma Malignant                                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05042-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 16:28:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      175MG/KG     350MG/KG                                               
                                                   FEMALE       LOW FEM       HIGHFEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            25          26          37                                                   
     Total Primary Neoplasms                           29          37          45                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 14          16          19                                                   
     Total Benign Neoplasms                            14          21          23                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              14          15          20                                                   
     Total Malignant Neoplasms                         15          16          22                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           3           4                                                   
     Total Metastatic Neoplasm                          3           6           6                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05042-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 16:28:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      175MG/KG     350MG/KG                                               
                                                   MALE         LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Scheduled Sacrifice                                  8           10            8                                                  
  Early Deaths                                                                                                                      
    Moribund                                          10            8           12                                                  
    Dead                                              14           13            9                                                  
    Dosing Accident                                    1            1            2                                                  
    Gavage Death                                       2            3            3                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                25           25           25                                                  
  Missing                                                                        1                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (47)         (25)         (46)                                                
   Intestine Large, Colon                             (49)         (26)         (47)                                                
   Intestine Small, Jejunum                           (45)         (23)         (44)                                                
      Adenocarcinoma                                                1 (4%)       2 (5%)                                             
   Liver                                              (50)         (50)         (50)                                                
      Adenocarcinoma, Metastatic                                                 1 (2%)                                             
      Adenocarcinoma, Metastatic, Intestine Small                                1 (2%)                                             
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
      Hemangiosarcoma                                  2 (4%)       4 (8%)                                                          
      Hemangiosarcoma, Metastatic                      1 (2%)                                                                       
      Hemangiosarcoma, Metastatic, Spleen              1 (2%)                                                                       
      Hepatoblastoma                                                             1 (2%)                                             
      Hepatocellular Carcinoma                         7 (14%)     10 (20%)      8 (16%)                                            
      Hepatocellular Carcinoma, Multiple               3 (6%)                    2 (4%)                                             
      Hepatocellular Adenoma                          12 (24%)     11 (22%)     11 (22%)                                            
      Hepatocellular Adenoma, Multiple                 8 (16%)      7 (14%)     17 (34%)                                            
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Sarcoma, Metastatic, Spleen                      1 (2%)                                                                       
   Mesentery                                          (9)          (2)          (4)                                                 
      Adenocarcinoma, Metastatic, Intestine Small                                1 (25%)                                            
      Fibrosarcoma, Metastatic, Skin                                             1 (25%)                                            
      Lipoma                                           1 (11%)                                                                      
   Pancreas                                           (49)         (26)         (49)                                                
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
   Salivary Glands                                    (49)         (24)         (49)                                                
   Stomach, Forestomach                               (49)         (50)         (49)                                                
      Squamous Cell Papilloma                                       1 (2%)       1 (2%)                                             
      Glandular, Mast Cell Tumor Malignant,                                                                                         
                                                             Page   7                                                               
NTP Experiment-Test: 05042-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 16:28:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      175MG/KG     350MG/KG                                               
                                                   MALE         LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
          Metastatic, Skin                                                       1 (2%)                                             
   Stomach, Glandular                                 (50)         (47)         (47)                                                
      Adenocarcinoma, Metastatic                                                 1 (2%)                                             
      Adenocarcinoma, Metastatic, Intestine Small                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (25)         (50)                                                
      Carcinoma, Metastatic, Uncertain Primary Site    1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (48)         (23)         (48)                                                
   Adrenal Gland, Medulla                             (46)         (23)         (43)                                                
      Pheochromocytoma Malignant                                                 1 (2%)                                             
      Pheochromocytoma Benign                                                    1 (2%)                                             
   Islets, Pancreatic                                 (49)         (25)         (49)                                                
      Adenoma                                                                    1 (2%)                                             
      Mast Cell Tumor Malignant, Metastatic, Skin                                1 (2%)                                             
   Thyroid Gland                                      (49)         (23)         (49)                                                
      Follicular Cell, Adenoma                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (24)         (47)                                                
   Preputial Gland                                    (7)          (3)          (5)                                                 
      Carcinoma                                                     1 (33%)                                                         
   Seminal Vesicle                                    (48)         (26)         (50)                                                
   Testes                                             (50)         (24)         (50)                                                
      Interstitial Cell, Adenoma                       2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (25)         (49)                                                
      Hemangiosarcoma, Metastatic                      2 (4%)                                                                       
      Hemangiosarcoma, Metastatic, Spleen              1 (2%)       1 (4%)                                                          
      Mast Cell Tumor Malignant, Metastatic, Skin                                1 (2%)                                             
                                                             Page   8                                                               
NTP Experiment-Test: 05042-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 16:28:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      175MG/KG     350MG/KG                                               
                                                   MALE         LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Lymph Node                                         (50)         (27)         (49)                                                
   Lymph Node, Mandibular                             (46)         (22)         (44)                                                
      Mast Cell Tumor Malignant, Metastatic, Skin                                1 (2%)                                             
   Lymph Node, Mesenteric                             (48)         (24)         (44)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Spleen                                             (50)         (28)         (49)                                                
      Hemangioma                                                    1 (4%)                                                          
      Hemangiosarcoma                                  3 (6%)                                                                       
      Hemangiosarcoma, Multiple                                     1 (4%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Mast Cell Tumor Malignant, Metastatic, Skin                                1 (2%)                                             
      Sarcoma                                          1 (2%)                                                                       
   Thymus                                             (29)         (17)         (33)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (35)         (49)                                                
      Hemangiosarcoma, Metastatic, Spleen                           1 (3%)                                                          
      Mast Cell Tumor Malignant                                                  1 (2%)                                             
      Subcutaneous Tissue, Fibroma                                  3 (9%)                                                          
      Subcutaneous Tissue, Fibroma, Multiple                                     1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)       4 (11%)      2 (4%)                                             
      Subcutaneous Tissue, Fibrosarcoma, Multiple                                1 (2%)                                             
      Subcutaneous Tissue, Hemangiosarcoma                          1 (3%)                                                          
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (25)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     7 (14%)      9 (18%)      7 (14%)                                            
      Alveolar/Bronchiolar Adenoma, Multiple                        2 (4%)       2 (4%)                                             
      Alveolar/Bronchiolar Carcinoma                   3 (6%)       1 (2%)       2 (4%)                                             
      Carcinoma, Metastatic, Uncertain Primary Site    1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Skin                                1 (2%)       1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      2 (4%)       3 (6%)       2 (4%)                                             
                                                             Page   9                                                               
NTP Experiment-Test: 05042-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 16:28:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      175MG/KG     350MG/KG                                               
                                                   MALE         LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Mast Cell Tumor Malignant, Metastatic, Skin                                1 (2%)                                             
   Nose                                               (50)         (25)         (50)                                                
      Carcinoma, Metastatic, Harderian Gland                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (6)          (5)          (7)                                                 
      Mast Cell Tumor Malignant, Metastatic, Skin                                1 (14%)                                            
   Harderian Gland                                    (48)         (49)         (47)                                                
      Adenoma                                          5 (10%)      8 (16%)      3 (6%)                                             
      Adenoma, Mild                                                              1 (2%)                                             
      Adenoma, Multiple                                                          1 (2%)                                             
      Carcinoma                                                                  1 (2%)                                             
      Bilateral, Adenoma                               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Carcinoma, Metastatic, Uncertain Primary Site    1 (2%)                                                                       
      Hemangiosarcoma                                  1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic                          1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                                                          
      Mast Cell Tumor Malignant, Metastatic, Skin                                1 (2%)                                             
      Renal Tubule, Adenoma                            1 (2%)                    1 (2%)                                             
      Renal Tubule, Carcinoma                                                    1 (2%)                                             
   Urinary Bladder                                    (50)         (24)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Lymphoma Malignant Mixed                         2 (4%)       3 (6%)       1 (2%)                                             
      Lymphoma Malignant Undifferentiated Cell         2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05042-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 16:28:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      175MG/KG     350MG/KG                                               
                                                   MALE         LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            38          39          42                                                   
     Total Primary Neoplasms                           64          68          71                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 28          28          32                                                   
     Total Benign Neoplasms                            37          42          48                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              22          21          21                                                   
     Total Malignant Neoplasms                         27          26          23                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              6           5           6                                                   
     Total Metastatic Neoplasm                         11           9          20                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.