National Toxicology Program

National Toxicology Program
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TR 391 Mouse Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Microbiological Assoc.                                    DATE: 09/05/94   
EXP: 05042              TRIS (2-CHLOROETHYL) PHOSPHATE         TIME: 16:38:01   
TEST: 02              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 60128    
CONT: N01CP9565001                                             CAS: 115-96-8    
PATHOLOGIST: J. MOE                                                             
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NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Microbiological Assoc.                                    DATE: 09/05/94  
EXP: 05042              TRIS (2-CHLOROETHYL) PHOSPHATE         TIME: 16:38:01  
TEST: 02              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 60128   
CONT: N01CP9565001                                             CAS: 115-96-8   
PATHOLOGIST: J. MOE                                                            

                          TRIS (2-CHLOROETHYL) PHOSPHATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 24     CENSORED DEATHS 11   TERMINAL 25        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      23    250   298   298   442   451   485   620   626   632                 |
 |      636   638   656   665   670   674   675   681   688   690                 |
 |      694   697   714   715                                                     |
 |  CENSORED DEATHS                                                               |
 |      297   458   458   458   458   458   458   458   458   654                 |
 |      675                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 175MG/KGLOW                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 21     CENSORED DEATHS 14   TERMINAL 25        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      297   480   532   620   623   626   626   638   649   653                 |
 |      655   663   663   664   669   673   679   688   694   712                 |
 |      718                                                                       |
 |  CENSORED DEATHS                                                               |
 |      3     289   389   458   458   458   458   458   458   458                 |
 |      458   458   458   572                                                     |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 350MG/KGHIGH                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 21     CENSORED DEATHS 14   TERMINAL 25        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      60    122   134   469   511   571   588   599   604   627                 |
 |      634   635   666   666   666   673   698   699   706   717                 |
 |      719                                                                       |
 |  CENSORED DEATHS                                                               |
 |      115   117   293   458   458   458   458   458   458   458                 |
 |      458   673   683   712                                                     |
 |                                                                                |
 ==================================================================================

                          TRIS (2-CHLOROETHYL) PHOSPHATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |    98.3  98.3  96.7  93.3  93.3  87.9  87.9  87.9  73.8  52.9      |
 |           |                                                                    |
 |           |                                                                    |
 |175MG/KGLOW|   100.0 100.0 100.0  98.3  98.3  96.1  94.0  94.0  70.0  54.7      |
 |           |                                                                    |
 |           |                                                                    |
 |350MG/KGHIG|    98.3  94.9  94.9  94.9  94.9  92.8  90.8  82.5  76.3  56.9      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          175MG/KGLOW      350MG/KGHIGH  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       52.9%            54.7%            56.9%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.745N         P=0.883N         P=0.792N      |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       567.4            629.6            560.2         |
 |NATURAL DEATHS (C)      |       (37.3)           (20.5)           (43.9)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       618.9            621.3            604.1         |
 |(STANDARD ERROR)        |       (20.2)           (19.0)           (23.8)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                          TRIS (2-CHLOROETHYL) PHOSPHATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 13     CENSORED DEATHS 16   TERMINAL 31        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      298   365   397   469   537   544   610   632   639   669                 |
 |      700   716   718                                                           |
 |  CENSORED DEATHS                                                               |
 |      236   302   302   304   360   458   458   458   458   458                 |
 |      458   458   458   458   540   669                                         |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 175MG/KGLOW                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 11     CENSORED DEATHS 12   TERMINAL 37        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      622   626   642   654   658   666   666   669   670   690                 |
 |      694                                                                       |
 |  CENSORED DEATHS                                                               |
 |      324   459   459   459   459   459   459   459   459   459                 |
 |      459   614                                                                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 350MG/KG HIGH                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 13     CENSORED DEATHS 12   TERMINAL 35        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      72    482   489   519   537   583   627   664   670   676                 |
 |      696   698   706                                                           |
 |  CENSORED DEATHS                                                               |
 |      459   459   459   459   459   459   459   459   459   459                 |
 |      676   719                                                                 |
 |                                                                                |
 ==================================================================================

                          TRIS (2-CHLOROETHYL) PHOSPHATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0  96.5  94.7  92.5  88.0  88.0  81.2  72.0      |
 |           |                                                                    |
 |           |                                                                    |
 |175MG/KGLOW|   100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0  89.6  77.1      |
 |           |                                                                    |
 |           |                                                                    |
 |350MG/KG   |    98.3  98.3  98.3  98.3  98.3  96.3  90.3  88.3  84.3  74.1      |
 |HIGH       |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          175MG/KGLOW      350MG/KG      |
 |                                                                  HIGH          |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       72.0%            77.1%            74.1%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.826N         P=0.551N         P=0.915N      |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       561.1            659.7            570.7         |
 |NATURAL DEATHS (C)      |       (39.0)           ( 6.9)           (47.4)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       612.1            662.6            648.7         |
 |(STANDARD ERROR)        |       (19.9)           (14.1)           (17.0)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                   TRIS (2-CHLOROETHYL) PHOSPHATE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        175MG/KGLOW      = 2
                                                        350MG/KGHIGH     = 3

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1   1     3                                    2
      |     1     3         3                   1      2                            2
      |
      |                     3 3                 1      1                            2       2
   95 +                       3                                                   3
      |                                                1                      1             2             2
      |                                                                           3     3
      |                                                                       1 1       3         3
   90 +                                                                         1    1                    22
      |                                                                                           3 3
      |                                                                              1                    1
      |                                                                                             3  3  11
P  85 +                                                                                                33  2 2
E     |                                                                                                    11
R     |                                                                                                 3  3 22
C     |                                                                                                       22
E  80 +                                                                                                    311
N     |
T     |                                                                                                      1 1
      |                                                                                                     3  1 13
S  75 +
U     |                                                                                                          11
R     |
V     |                                                                                                           11
I  70 +                                                                                                          223
V     |
A     |                                                                                                           211 3
L     |
   65 +                                                                                                             11
      |                                                                                                            2 233
      |
      |                                                                                                              113 3
   60 +
      |                                                                                                               2 2
      |                                                                                                               1 13  3
      |                                                                                                                 22
   55 +                                                                                                                 11  2
      |
      |                                                                                                                  1  1
      |
   50 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 11 obs hidden.

                                                   TRIS (2-CHLOROETHYL) PHOSPHATE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        175MG/KGLOW      = 2
                                                        350MG/KG HIGH    = 3

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1           3                                  1                                                  2
      |             3                                  1          1                 3
      |                                                                                                   22
      |                                                           1    1            33                     2 2
P  95 +                                                                1          1
E     |                                                                              3     3                 2 2
R     |                                                                           1        3 1
C     |
E  90 +                                                                                      11     3          2  2
N     |                                                                                             3      3
T     |                                                                                       1          1
      |                                                                                                  1 31    3
S  85 +
U     |                                                                                                     11   33
R     |                                                                                                           33
V     |                                                                                                      1    1  2
I  80 +                                                                                                            3  3
V     |                                                                                                           1  21
A     |                                                                                                               2     2
L     |                                                                                                               13 1
   75 +
      |                                                                                                                3    3
      |                                                                                                                  1  1
      |
   70 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 7 obs hidden.

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