National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3498

TR 391 Rat Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                    TRIS 2-CHLOROETHYL PHOSPHATE


NTP Experiment-Test: 05042-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/05/94
Route: GAVAGE                                                                                                     Time: 14:55:44




       Facility:  Microbiological Associates

       Chemical CAS #:  115-96-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05042-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    TRIS 2-CHLOROETHYL PHOSPHATE                               Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 14:55:44  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      44MG/KG      88 MG/KG                                               
                                                   FEMALE       LOW FEM       HIGHFEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10            9                                                  
  Early Deaths                                                                                                                      
    Dead                                               9            4            7                                                  
    Moribund                                           8           10           22                                                  
    Accident                                           1                         1                                                  
    Gavage Death                                                    3            4                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           33           17                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (50)         (49)         (50)                                                
      Sarcoma Stromal, Metastatic, Uterus                                        1 (2%)                                             
   Mesentery                                          (4)          (4)          (1)                                                 
      Sarcoma Stromal, Metastatic, Uterus                                        1 (100%)                                           
   Pancreas                                           (49)         (49)         (50)                                                
      Sarcoma Stromal, Metastatic, Uterus                                        1 (2%)                                             
   Salivary Glands                                    (50)         (49)         (50)                                                
   Stomach, Forestomach                               (50)         (50)         (49)                                                
   Stomach, Glandular                                 (50)         (50)         (50)                                                
   Tongue                                             (1)                                                                           
      Squamous Cell Papilloma                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
      Endocardium, Schwannoma Malignant                2 (4%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (48)         (50)         (50)                                                
      Carcinoma                                        1 (2%)                                                                       
   Adrenal Gland, Medulla                             (43)         (41)         (45)                                                
      Pheochromocytoma Benign                                       2 (5%)                                                          
   Islets, Pancreatic                                 (50)         (50)         (50)                                                
      Adenoma                                                                    1 (2%)                                             
   Pituitary Gland                                    (49)         (49)         (47)                                                
      Carcinoma                                                     1 (2%)                                                          
                                                             Page   2                                                               
NTP Experiment-Test: 05042-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    TRIS 2-CHLOROETHYL PHOSPHATE                               Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 14:55:44  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      44MG/KG      88 MG/KG                                               
                                                   FEMALE       LOW FEM       HIGHFEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pars Distalis, Adenoma                          21 (43%)     14 (29%)     11 (23%)                                            
      Pars Distalis, Carcinoma                         1 (2%)       1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (50)                                                
      Bilateral, C-Cell, Adenoma                       2 (4%)                                                                       
      C-Cell, Adenoma                                               2 (4%)       3 (6%)                                             
      C-Cell, Carcinoma                                1 (2%)       1 (2%)       1 (2%)                                             
      Follicular Cell, Adenoma                                      1 (2%)       1 (2%)                                             
      Follicular Cell, Carcinoma                                    2 (4%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (34)         (35)         (32)                                                
      Adenoma                                          7 (21%)      3 (9%)       4 (13%)                                            
      Carcinoma                                        2 (6%)       4 (11%)      2 (6%)                                             
   Ovary                                              (49)         (50)         (50)                                                
   Uterus                                             (50)         (50)         (50)                                                
      Leiomyoma                                        1 (2%)                                                                       
      Polyp Stromal                                    9 (18%)     13 (26%)     11 (22%)                                            
      Polyp Stromal, Multiple                          1 (2%)                    1 (2%)                                             
      Sarcoma Stromal                                                            3 (6%)                                             
      Endometrium, Adenoma                                          1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
   Lymph Node                                         (50)         (49)         (49)                                                
   Lymph Node, Mandibular                             (47)         (45)         (47)                                                
   Lymph Node, Mesenteric                             (48)         (45)         (49)                                                
   Spleen                                             (50)         (49)         (50)                                                
   Thymus                                             (37)         (42)         (39)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (46)         (46)         (47)                                                
      Adenocarcinoma                                   3 (7%)       3 (7%)       3 (6%)                                             
      Adenoma                                                       1 (2%)       1 (2%)                                             
      Fibroadenoma                                    14 (30%)     16 (35%)     13 (28%)                                            
      Fibroadenoma, Multiple                           3 (7%)       5 (11%)      5 (11%)                                            
   Skin                                               (50)         (49)         (49)                                                
                                                             Page   3                                                               
NTP Experiment-Test: 05042-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    TRIS 2-CHLOROETHYL PHOSPHATE                               Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 14:55:44  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      44MG/KG      88 MG/KG                                               
                                                   FEMALE       LOW FEM       HIGHFEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Sarcoma                                          1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     1 (2%)                                                                       
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Schwannoma Malignant        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (2)          (1)          (2)                                                 
      Osteosarcoma                                                  1 (100%)     1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Astrocytoma Benign                                            1 (2%)                                                          
      Carcinoma, Metastatic                                         1 (2%)                                                          
      Carcinoma, Metastatic, Pituitary Gland           1 (2%)                                                                       
      Glioma Malignant                                                           1 (2%)                                             
      Cerebellum, Meninges, Granular Cell Tumor                                                                                     
          Benign                                                    2 (4%)                                                          
      Cerebrum, Oligodendroglioma Malignant            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Adenocarcinoma, Metastatic, Mammary Gland        1 (2%)                                                                       
      Alveolar/Bronchiolar Adenoma                     1 (2%)       1 (2%)       1 (2%)                                             
      Carcinoma, Metastatic, Adrenal Gland             1 (2%)                                                                       
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
   Nose                                               (50)         (50)         (50)                                                
      Squamous Cell Carcinoma                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)                                                                           
      Carcinoma                                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Renal Tubule, Adenoma                                         2 (4%)       5 (10%)                                            
      Transitional Epithelium, Carcinoma                                         1 (2%)                                             
   Urinary Bladder                                    (49)         (49)         (48)                                                
                                                             Page   4                                                               
NTP Experiment-Test: 05042-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    TRIS 2-CHLOROETHYL PHOSPHATE                               Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 14:55:44  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      44MG/KG      88 MG/KG                                               
                                                   FEMALE       LOW FEM       HIGHFEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Monocytic                               1 (2%)                                                                       
      Leukemia Mononuclear                            14 (28%)     16 (32%)     20 (40%)                                            
      Lymphoma Malignant                                            1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05042-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    TRIS 2-CHLOROETHYL PHOSPHATE                               Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 14:55:44  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      44MG/KG      88 MG/KG                                               
                                                   FEMALE       LOW FEM       HIGHFEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            45          46          44                                                   
     Total Primary Neoplasms                           91          95          95                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 35          38          32                                                   
     Total Benign Neoplasms                            61          64          58                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              26          25          30                                                   
     Total Malignant Neoplasms                         30          31          37                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           2           1                                                   
     Total Metastatic Neoplasm                          3           2           3                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05042-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    TRIS 2-CHLOROETHYL PHOSPHATE                               Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 14:55:44  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      44MG/KG      88 MG/KG                                               
                                                   MALE         LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Scheduled Sacrifice                                  9           10           10                                                  
  Early Deaths                                                                                                                      
    Dead                                               6            9           10                                                  
    Moribund                                           5            7           14                                                  
    Gavage Death                                       4            1                                                               
    Accident                                                                     1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           33           25                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (47)         (48)                                                
   Intestine Small, Duodenum                          (48)         (46)         (47)                                                
      Leiomyosarcoma                                                1 (2%)                                                          
   Intestine Small, Ileum                             (48)         (46)         (47)                                                
   Liver                                              (50)         (50)         (50)                                                
      Hepatocellular Carcinoma                                      1 (2%)       1 (2%)                                             
      Hepatocellular Adenoma                                                     1 (2%)                                             
      Sarcoma, Metastatic, Mesentery                                             1 (2%)                                             
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (2%)                                                          
   Mesentery                                          (13)         (8)          (10)                                                
      Sarcoma                                                                    1 (10%)                                            
   Pancreas                                           (49)         (48)         (50)                                                
      Sarcoma, Metastatic, Mesentery                                             1 (2%)                                             
      Acinus, Adenocarcinoma                                        1 (2%)                                                          
      Acinus, Adenoma                                                            1 (2%)                                             
   Salivary Glands                                    (50)         (49)         (49)                                                
      Sarcoma                                                       1 (2%)                                                          
   Stomach, Forestomach                               (50)         (48)         (50)                                                
   Stomach, Glandular                                 (50)         (48)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05042-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    TRIS 2-CHLOROETHYL PHOSPHATE                               Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 14:55:44  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      44MG/KG      88 MG/KG                                               
                                                   MALE         LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (49)                                                
      Carcinoma                                                                  1 (2%)                                             
   Adrenal Gland, Medulla                             (43)         (47)         (44)                                                
      Pheochromocytoma Malignant                       2 (5%)       1 (2%)       5 (11%)                                            
      Pheochromocytoma Benign                          9 (21%)     15 (32%)     12 (27%)                                            
      Pheochromocytoma Benign, Multiple                             1 (2%)                                                          
      Bilateral, Pheochromocytoma Benign               1 (2%)       5 (11%)      1 (2%)                                             
   Islets, Pancreatic                                 (50)         (49)         (50)                                                
      Adenoma                                          1 (2%)       2 (4%)       3 (6%)                                             
      Carcinoma                                                                  1 (2%)                                             
   Pituitary Gland                                    (49)         (46)         (48)                                                
      Pars Distalis, Adenoma                          19 (39%)     16 (35%)     14 (29%)                                            
      Pars Distalis, Carcinoma                         2 (4%)                                                                       
   Thyroid Gland                                      (50)         (48)         (50)                                                
      C-Cell, Adenoma                                 14 (28%)      8 (17%)      4 (8%)                                             
      C-Cell, Carcinoma                                             1 (2%)       2 (4%)                                             
      Follicular Cell, Adenoma                         1 (2%)       2 (4%)       3 (6%)                                             
      Follicular Cell, Carcinoma                                                 2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (49)         (49)                                                
   Preputial Gland                                    (42)         (47)         (42)                                                
      Adenoma                                          1 (2%)                    1 (2%)                                             
      Carcinoma                                        3 (7%)       7 (15%)      6 (14%)                                            
   Prostate                                           (50)         (50)         (50)                                                
      Adenoma                                          1 (2%)                                                                       
   Seminal Vesicle                                    (50)         (48)         (50)                                                
      Sarcoma, Metastatic, Mesentery                                             1 (2%)                                             
   Testes                                             (50)         (50)         (49)                                                
      Bilateral, Interstitial Cell, Adenoma           30 (60%)     30 (60%)     35 (71%)                                            
      Interstitial Cell, Adenoma                       8 (16%)     11 (22%)      7 (14%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (49)         (50)                                                
   Lymph Node                                         (50)         (49)         (50)                                                
      Mediastinal, Sarcoma, Metastatic                                           1 (2%)                                             
      Mediastinal, Sarcoma, Metastatic, Mesentery                                1 (2%)                                             
                                                             Page   8                                                               
NTP Experiment-Test: 05042-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    TRIS 2-CHLOROETHYL PHOSPHATE                               Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 14:55:44  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      44MG/KG      88 MG/KG                                               
                                                   MALE         LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Lymph Node, Mandibular                             (44)         (42)         (47)                                                
   Lymph Node, Mesenteric                             (48)         (43)         (43)                                                
   Spleen                                             (50)         (49)         (50)                                                
      Hemangiosarcoma                                                            1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
      Sarcoma                                          1 (2%)                    1 (2%)                                             
   Thymus                                             (37)         (38)         (39)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (29)         (26)         (32)                                                
      Adenocarcinoma                                   1 (3%)                                                                       
      Fibroadenoma                                     2 (7%)       1 (4%)                                                          
   Skin                                               (50)         (50)         (48)                                                
      Basal Cell Adenoma                               1 (2%)       1 (2%)       1 (2%)                                             
      Basosquamous Tumor Benign                                     1 (2%)                                                          
      Keratoacanthoma                                               3 (6%)       2 (4%)                                             
      Squamous Cell Carcinoma                                       2 (4%)       1 (2%)                                             
      Squamous Cell Papilloma                          1 (2%)                                                                       
      Sebaceous Gland, Adenoma                                      1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                     1 (2%)       3 (6%)       6 (13%)                                            
      Subcutaneous Tissue, Fibrosarcoma                2 (4%)                                                                       
      Subcutaneous Tissue, Lipoma, Multiple                         1 (2%)                                                          
      Subcutaneous Tissue, Sarcoma, Metastatic                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                                            (3)          (3)                                                 
      Femur, Osteosarcoma                                           1 (33%)                                                         
      Humerus, Osteosarcoma                                         1 (33%)                                                         
      Vertebra, Chordoma                                                         1 (33%)                                            
      Vertebra, Sarcoma, Metastatic                                              1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (50)                                                
      Carcinoma, Metastatic, Pituitary Gland           1 (2%)                                                                       
      Granular Cell Tumor Benign                                                 1 (2%)                                             
      Cerebellum, Meninges, Granular Cell Tumor                                                                                     
          Benign                                                                 2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05042-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    TRIS 2-CHLOROETHYL PHOSPHATE                               Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 14:55:44  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      44MG/KG      88 MG/KG                                               
                                                   MALE         LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (49)         (50)                                                
      Alveolar/Bronchiolar Adenoma                                               1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                                             1 (2%)                                             
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)                                                          
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Osteosarcoma, Metastatic, Bone                                2 (4%)                                                          
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                                          2 (4%)                                             
      Sarcoma, Metastatic, Salivary Glands                          1 (2%)                                                          
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                               (1)                                                 
      Carcinoma                                                                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Lipoma                                                                     1 (2%)                                             
      Renal Tubule, Adenoma                            1 (2%)       4 (8%)      16 (32%)                                            
      Renal Tubule, Adenoma, Multiple                               1 (2%)       8 (16%)                                            
      Renal Tubule, Carcinoma                          1 (2%)                    1 (2%)                                             
   Urinary Bladder                                    (49)         (49)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                             5 (10%)     14 (28%)     13 (26%)                                            
      Mesothelioma Benign                                           2 (4%)       1 (2%)                                             
      Mesothelioma Malignant                           1 (2%)       2 (4%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05042-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                    TRIS 2-CHLOROETHYL PHOSPHATE                               Date: 09/05/94  
Route: GAVAGE                                                                                                     Time: 14:55:44  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      44MG/KG      88 MG/KG                                               
                                                   MALE         LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            48          48          49                                                   
     Total Primary Neoplasms                          109         141         163                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 46          46          49                                                   
     Total Benign Neoplasms                            91         108         121                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              16          29          30                                                   
     Total Malignant Neoplasms                         18          33          42                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           7           6                                                   
     Total Metastatic Neoplasm                          3          11          11                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.