National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1180

TR 392 Mouse Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                             CHLORAMINE


NTP Experiment-Test: 05089-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/11/94
Route: DOSED WATER                                                                                                Time: 22:29:07




       Facility:  Southern Research Institute

       Chemical CAS #:   10599903

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05089-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      VEHICLE      0.00500%     0.00500%     0.00700%     0.00700%        
                                                   CONTROL      3 SSAC                     3 SSAC                    3 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           10           60           10           60           10           
  Scheduled Sacrifice                                 10           10           10           10            9           10           
  Early Deaths                                                                                                                      
    Natural Death                                      3                         3                         6                        
    Moribund Sacrifice                                13                        14                        14                        
    Accidently Killed                                  1                         1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                33                        32                        31                        
  Animals Examined Microscopically                    60           10           60            6           60                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (57)         (9)          (49)                      (49)                      
   Intestine Small, Duodenum                          (58)         (9)          (46)                      (51)                      
      Fibrous Histiocytoma                                                       1 (2%)                                             
   Intestine Small, Ileum                             (58)         (10)         (50)                      (51)                      
   Intestine Small, Jejunum                           (58)         (10)         (49)                      (51)                      
   Liver                                              (60)         (10)         (50)                      (51)                      
      Chemodectoma Malignant, Metastatic, Thyroid                                                                                   
          Gland                                                                                            1 (2%)                   
      Fibrous Histiocytoma                             1 (2%)                    1 (2%)                                             
      Hemangiosarcoma                                  1 (2%)                                                                       
      Hepatocellular Carcinoma                         6 (10%)                   8 (16%)                   6 (12%)                  
      Hepatocellular Carcinoma, Multiple, Two                                    3 (6%)                    1 (2%)                   
      Hepatocellular Adenoma                          14 (23%)                  10 (20%)                  11 (22%)                  
      Hepatocellular Adenoma, Multiple, Two            3 (5%)                    1 (2%)                    6 (12%)                  
      Hepatocellular Adenoma, Multiple, Three          1 (2%)                    1 (2%)                                             
      Hepatocellular Adenoma, Multiple, Four           1 (2%)                    2 (4%)                    1 (2%)                   
      Hepatocellular Adenoma, Multiple, Five           1 (2%)                                                                       
      Hepatocellular Adenoma, Multiple, Greater                                                                                     
          Than Five                                                                                        1 (2%)                   
      Histiocytic Sarcoma                                                                                  1 (2%)                   
   Mesentery                                          (17)                      (8)                       (10)                      
      Chemodectoma Malignant                           1 (6%)                                                                       
      Hemangiosarcoma                                  1 (6%)                                                                       
      Histiocytic Sarcoma                                                                                  1 (10%)                  
   Pancreas                                           (60)         (10)         (50)                      (50)                      
      Fibrous Histiocytoma                             1 (2%)                    1 (2%)                                             
      Hemangioma                                       1 (2%)                                                                       
   Salivary Glands                                    (59)         (10)         (50)                      (51)                      
   Stomach, Forestomach                               (60)         (10)         (50)                      (51)                      
      Hemangioma                                       1 (2%)                                                                       
                                                             Page   2                                                               
NTP Experiment-Test: 05089-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      VEHICLE      0.00500%     0.00500%     0.00700%     0.00700%        
                                                   CONTROL      3 SSAC                     3 SSAC                    3 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Leiomyoma                                        1 (2%)                                                                       
   Stomach, Glandular                                 (60)         (10)         (50)                      (51)                      
      Carcinoid Tumor Malignant                                                                            1 (2%)                   
      Fibrous Histiocytoma                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (2)                                                 (1)                       
   Heart                                              (60)         (10)         (50)                      (51)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (10)         (50)                      (51)                      
      Histiocytic Sarcoma                                                                                  1 (2%)                   
   Islets, Pancreatic                                 (60)         (10)         (50)                      (50)                      
      Adenoma                                                                                              1 (2%)                   
   Pituitary Gland                                    (58)         (9)          (50)                      (50)                      
      Pars Distalis, Adenoma                           5 (9%)                   11 (22%)                   8 (16%)                  
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
   Thyroid Gland                                      (60)         (10)         (49)                      (51)                      
      Chemodectoma Malignant                                                                               1 (2%)                   
      Follicular Cell, Adenoma                         3 (5%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (56)         (10)         (46)                      (46)                      
      Adenoma                                          2 (4%)                                                                       
      Cystadenoma                                      1 (2%)                    1 (2%)                                             
      Granulosa-Theca Tumor Benign                                                                         1 (2%)                   
      Hemangioma                                       1 (2%)                                                                       
      Teratoma Benign                                  1 (2%)                                                                       
   Uterus                                             (60)         (10)         (60)         (2)          (59)                      
      Carcinoma                                                                  1 (2%)                    1 (2%)                   
      Histiocytic Sarcoma                                                                                  1 (2%)                   
      Leiomyosarcoma                                   1 (2%)                                                                       
      Polyp Stromal                                                              3 (5%)                                             
      Sarcoma                                          1 (2%)                                                                       
      Sarcoma Stromal                                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                             Page   3                                                               
NTP Experiment-Test: 05089-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      VEHICLE      0.00500%     0.00500%     0.00700%     0.00700%        
                                                   CONTROL      3 SSAC                     3 SSAC                    3 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (10)         (50)                      (51)                      
      Fibrous Histiocytoma                             1 (2%)                                                                       
   Lymph Node                                         (60)         (10)         (50)                      (51)                      
      Axillary, Fibrosarcoma, Metastatic, Skin         1 (2%)                                                                       
      Renal, Fibrous Histiocytoma                                                1 (2%)                                             
   Lymph Node, Mandibular                             (56)         (10)         (49)                      (49)                      
   Lymph Node, Mesenteric                             (59)         (9)          (50)                      (47)                      
      Fibrous Histiocytoma                                                       1 (2%)                                             
      Renal, Iliac, Mediastinal, Mandibular,                                                                                        
          Fibrous Histiocytoma                         1 (2%)                                                                       
   Spleen                                             (59)         (10)         (50)                      (51)                      
      Fibrous Histiocytoma                             1 (2%)                    1 (2%)                                             
      Hemangiosarcoma                                  1 (2%)                                              1 (2%)                   
   Thymus                                             (58)         (10)         (47)                      (49)                      
      Fibrous Histiocytoma                             1 (2%)                                                                       
      Thymoma Benign                                   1 (2%)                    1 (2%)                    2 (4%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (10)         (50)                      (51)                      
      Fibrosarcoma                                     1 (2%)                                                                       
      Mast Cell Tumor Benign                                                     1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                                                                    2 (4%)                   
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
      Subcutaneous Tissue, Schwannoma Malignant                                  2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (10)         (50)                      (51)                      
      Osteosarcoma                                     1 (2%)                                                                       
   Skeletal Muscle                                    (2)                                                 (3)                       
      Fibrosarcoma, Metastatic, Skin                   1 (50%)                                             1 (33%)                  
      Histiocytic Sarcoma                                                                                  1 (33%)                  
      Osteosarcoma, Metastatic, Bone                   1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05089-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      VEHICLE      0.00500%     0.00500%     0.00700%     0.00700%        
                                                   CONTROL      3 SSAC                     3 SSAC                    3 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (10)         (50)                      (51)                      
      Alveolar/Bronchiolar Adenoma                     4 (7%)                    3 (6%)                    5 (10%)                  
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                    2 (4%)                    6 (12%)                  
      Chemodectoma Malignant, Metastatic, Thyroid                                                                                   
          Gland                                                                                            1 (2%)                   
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Fibrous Histiocytoma                                                       1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                    2 (4%)                                             
      Histiocytic Sarcoma                                                                                  1 (2%)                   
      Schwannoma Malignant, Metastatic, Skin                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)                       (1)                       (3)                       
      Adenoma                                          1 (100%)                  1 (100%)                                           
      Carcinoma                                                                                            1 (33%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (10)         (53)         (4)          (57)                      
      Fibrous Histiocytoma                             1 (2%)                    1 (2%)                                             
      Renal Tubule, Carcinoma                                                    1 (2%)                                             
   Urinary Bladder                                    (59)         (10)         (49)                      (50)                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(10)        *(60)        *(6)         *(60)                      
      Histiocytic Sarcoma                                                                                  2 (3%)                   
      Leukemia Erythrocytic                            1 (2%)                                                                       
      Leukemia Granulocytic                                                                                1 (2%)                   
      Lymphoma Malignant Lymphocytic                   2 (3%)                                              3 (5%)                   
      Lymphoma Malignant Mixed                         7 (12%)                   5 (8%)                   10 (17%)                  
      Lymphoma Malignant Undifferentiated Cell                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05089-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      VEHICLE      0.00500%     0.00500%     0.00700%     0.00700%        
                                                   CONTROL      3 SSAC                     3 SSAC                    3 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            38                      40                      43                           
     Total Primary Neoplasms                           76                      69                      72                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 29                      28                      27                           
     Total Benign Neoplasms                            43                      36                      36                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              23                      21                      30                           
     Total Malignant Neoplasms                         33                      33                      36                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3                       3                       2                           
     Total Metastatic Neoplasm                          5                       3                       3                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05089-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0100%      0.0100%      0.0140%      0.0140%      0.0200%      0.0200%         
                                                                3 SSAC                    3 SSAC                    3 SSAC          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           10           60           10           60           10           
  Scheduled Sacrifice                                 10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Natural Death                                      6                         3                         3                        
    Moribund Sacrifice                                 9                        19                         5                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                35                        27                        42                        
    Natural Death                                                                1                                                  
  Animals Examined Microscopically                    60            4           60            1           60           10           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (48)                      (48)                      (59)         (9)          
   Intestine Large, Cecum                             (50)                      (50)                      (59)         (10)         
   Intestine Small, Ileum                             (49)                      (49)                      (57)         (10)         
      Histiocytic Sarcoma                                                                                  1 (2%)                   
   Intestine Small, Jejunum                           (49)                      (49)                      (58)         (10)         
   Liver                                              (50)                      (50)                      (60)         (10)         
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Fibrous Histiocytoma                                                       1 (2%)                    1 (2%)                   
      Hepatoblastoma                                                             1 (2%)                                             
      Hepatocellular Carcinoma                         4 (8%)                    6 (12%)                   3 (5%)                   
      Hepatocellular Carcinoma, Multiple, Two          2 (4%)                                                                       
      Hepatocellular Carcinoma, Multiple, Four                                   1 (2%)                                             
      Hepatocellular Adenoma                          18 (36%)                   7 (14%)                  11 (18%)                  
      Hepatocellular Adenoma, Multiple, Two            2 (4%)                    5 (10%)                   2 (3%)                   
      Hepatocellular Adenoma, Multiple, Three          1 (2%)                    4 (8%)                                             
      Hepatocellular Adenoma, Multiple, Four           1 (2%)                    2 (4%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Histiocytic Sarcoma, Metastatic                                                                      1 (2%)                   
   Mesentery                                          (8)                       (12)                      (2)                       
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (8%)                                             
      Fibrous Histiocytoma                                                       1 (8%)                                             
   Pancreas                                           (49)                      (49)                      (60)         (10)         
   Salivary Glands                                    (50)                      (50)                      (60)         (10)         
   Stomach, Glandular                                 (50)                      (50)                      (59)         (10)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05089-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0100%      0.0100%      0.0140%      0.0140%      0.0200%      0.0200%         
                                                                3 SSAC                    3 SSAC                    3 SSAC          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)                      (50)                      (60)         (10)         
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Fibrous Histiocytoma                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)                      (50)                      (60)         (10)         
      Adenoma                                          1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Capsule, Adenoma                                                                                     1 (2%)                   
   Adrenal Gland, Medulla                             (50)                      (50)                      (60)         (9)          
      Pheochromocytoma Benign                          1 (2%)                    1 (2%)                    1 (2%)                   
   Islets, Pancreatic                                 (48)                      (49)                      (60)         (10)         
      Adenoma                                          2 (4%)                    1 (2%)                    1 (2%)                   
      Carcinoma                                        1 (2%)                                                                       
   Pituitary Gland                                    (47)                      (48)                      (60)         (8)          
      Pars Distalis, Adenoma                           4 (9%)                    4 (8%)                    2 (3%)                   
      Pars Distalis, Carcinoma                                                                             1 (2%)                   
   Thyroid Gland                                      (50)                      (50)                      (59)         (10)         
      Follicular Cell, Adenoma                         1 (2%)                                                                       
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                   (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (48)                      (48)                      (57)         (10)         
      Adenoma                                                                                              1 (2%)                   
      Cystadenoma                                      1 (2%)                    1 (2%)                    1 (2%)                   
      Hemangioma                                       1 (2%)                                                                       
   Uterus                                             (59)         (4)          (60)         (1)          (60)         (10)         
      Carcinoma                                        1 (2%)                                                                       
      Hemangiosarcoma                                                                                      1 (2%)                   
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                    2 (3%)                   
      Polyp Stromal                                    2 (3%)                    1 (2%)                    1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05089-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0100%      0.0100%      0.0140%      0.0140%      0.0200%      0.0200%         
                                                                3 SSAC                    3 SSAC                    3 SSAC          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)                      (50)                      (60)         (10)         
      Fibrous Histiocytoma                                                       1 (2%)                    1 (2%)                   
      Hemangiosarcoma                                                                                      1 (2%)                   
   Lymph Node                                         (50)                      (50)                      (60)         (10)         
      Bronchial, Alveolar/Bronchiolar Carcinoma,                                                                                    
           Metastatic, Lung                                                      1 (2%)                                             
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                      1 (2%)                                             
   Lymph Node, Mandibular                             (47)                      (50)                      (60)         (10)         
      Carcinoma, Metastatic, Harderian Gland                                     1 (2%)                                             
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
   Lymph Node, Mesenteric                             (48)                      (48)                      (56)         (10)         
   Spleen                                             (50)                      (49)                      (60)         (10)         
      Fibrous Histiocytoma                                                       1 (2%)                    1 (2%)                   
      Hemangioma                                                                                           1 (2%)                   
      Hemangiosarcoma                                                            1 (2%)                    1 (2%)                   
   Thymus                                             (47)                      (46)                      (51)         (10)         
      Fibrous Histiocytoma                                                       1 (2%)                                             
      Thymoma Benign                                                                                       1 (2%)                   
      Thymoma Malignant                                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)                      (50)                      (60)         (10)         
   Skin                                               (49)                      (50)                      (58)         (10)         
      Subcutaneous Tissue, Fibrosarcoma                                          3 (6%)                                             
      Subcutaneous Tissue, Hemangiosarcoma                                       1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                                                                         1 (2%)                   
      Subcutaneous Tissue, Schwannoma Malignant                                                            1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)                      (50)                      (60)         (10)         
      Fibrous Histiocytoma                                                       1 (2%)                                             
      Osteosarcoma                                                               2 (4%)                                             
   Skeletal Muscle                                                              (1)                                                 
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05089-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0100%      0.0100%      0.0140%      0.0140%      0.0200%      0.0200%         
                                                                3 SSAC                    3 SSAC                    3 SSAC          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)                      (50)                      (60)         (10)         
      Fibrous Histiocytoma                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)                      (50)                      (60)         (10)         
      Alveolar/Bronchiolar Adenoma                     2 (4%)                    2 (4%)                    2 (3%)                   
      Alveolar/Bronchiolar Adenoma, Multiple, Two                                                          1 (2%)                   
      Alveolar/Bronchiolar Carcinoma                   2 (4%)                    5 (10%)                                            
      Carcinoma, Metastatic, Harderian Gland                                     1 (2%)                                             
      Fibrous Histiocytoma                                                       1 (2%)                    1 (2%)                   
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                    1 (2%)                    1 (2%)                   
   Nose                                               (50)                      (50)                      (60)         (10)         
      Glands, Carcinoma                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)                       (4)                       (6)                       
      Adenoma                                                                    1 (25%)                   4 (67%)                  
      Carcinoma                                        1 (100%)                  1 (25%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (57)                      (56)                      (60)         (10)         
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Urinary Bladder                                    (49)                      (49)                      (60)         (10)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(4)         *(60)        *(1)         *(60)        *(10)         
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                    2 (3%)                   
      Leukemia Erythrocytic                            1 (2%)                                                                       
      Lymphoma Malignant Lymphocytic                   1 (2%)                    1 (2%)                    3 (5%)                   
      Lymphoma Malignant Mixed                         4 (7%)                    7 (12%)                  11 (18%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05089-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0100%      0.0100%      0.0140%      0.0140%      0.0200%      0.0200%         
                                                                3 SSAC                    3 SSAC                    3 SSAC          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            35                      37                      32                           
     Total Primary Neoplasms                           57                      69                      59                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 28                      23                      22                           
     Total Benign Neoplasms                            37                      29                      30                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              16                      25                      21                           
     Total Malignant Neoplasms                         20                      40                      29                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1                       4                       2                           
     Total Metastatic Neoplasm                          1                      12                       2                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
NTP Experiment-Test: 05089-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0275%      0.0275%                                                             
                                                                3 SSAC                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           10                                                               
  Scheduled Sacrifice                                 10           10                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                12                                                                            
    Natural Death                                      3                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                35                                                                            
  Animals Examined Microscopically                    60           10                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (60)         (10)                                                             
   Intestine Small, Jejunum                           (60)         (10)                                                             
      Hemangioma                                       1 (2%)                                                                       
   Liver                                              (60)         (10)                                                             
      Hepatocellular Carcinoma                         5 (8%)                                                                       
      Hepatocellular Adenoma                          18 (30%)                                                                      
      Hepatocellular Adenoma, Multiple, Two            4 (7%)                                                                       
      Hepatocellular Adenoma, Multiple, Greater                                                                                     
          Than Five                                    1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
   Mesentery                                          (8)                                                                           
   Pancreas                                           (60)         (10)                                                             
   Salivary Glands                                    (60)         (10)                                                             
   Stomach, Forestomach                               (60)         (10)                                                             
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Squamous Cell Papilloma                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (9)                                                              
   Adrenal Gland, Medulla                             (60)         (9)                                                              
      Pheochromocytoma Malignant                       1 (2%)                                                                       
   Islets, Pancreatic                                 (60)         (10)                                                             
      Adenoma                                          1 (2%)                                                                       
                                                             Page  12                                                               
NTP Experiment-Test: 05089-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0275%      0.0275%                                                             
                                                                3 SSAC                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Pituitary Gland                                    (60)         (9)                                                              
      Pars Distalis, Adenoma                           6 (10%)                                                                      
   Thyroid Gland                                      (60)         (10)                                                             
      Follicular Cell, Adenoma                         2 (3%)                                                                       
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (56)         (9)                                                              
      Cystadenocarcinoma                               1 (2%)                                                                       
   Uterus                                             (60)         (10)                                                             
      Deciduoma Benign                                              1 (10%)                                                         
      Polyp Stromal                                    4 (7%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (60)         (10)                                                             
      Mediastinal, Osteosarcoma, Metastatic, Bone      1 (2%)                                                                       
   Lymph Node, Mandibular                             (58)         (10)                                                             
   Lymph Node, Mesenteric                             (58)         (10)                                                             
   Spleen                                             (60)         (10)                                                             
      Hemangioma                                       1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Thymus                                             (55)         (10)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (10)                                                             
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (10)                                                             
      Osteosarcoma                                     1 (2%)                                                                       
   Skeletal Muscle                                    (1)                                                                           
      Sarcoma                                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                             Page  13                                                               
NTP Experiment-Test: 05089-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0275%      0.0275%                                                             
                                                                3 SSAC                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (10)                                                             
      Alveolar/Bronchiolar Adenoma                     3 (5%)                                                                       
      Alveolar/Bronchiolar Carcinoma                   2 (3%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      2 (3%)                                                                       
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (8)                                                                           
      Adenoma                                          4 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (10)                                                             
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
   Urinary Bladder                                    (60)         (10)                                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(10)                                                             
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Lymphoma Malignant Lymphocytic                   2 (3%)                                                                       
      Lymphoma Malignant Mixed                         4 (7%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  14                                                               
NTP Experiment-Test: 05089-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0.0275%      0.0275%                                                             
                                                                3 SSAC                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            42           1                                                               
     Total Primary Neoplasms                           67           1                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 36           1                                                               
     Total Benign Neoplasms                            46           1                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              19                                                                           
     Total Malignant Neoplasms                         21                                                                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3                                                                           
     Total Metastatic Neoplasm                          6                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  15                                                               
NTP Experiment-Test: 05089-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      VEHICLE      0.00500%     0.00500%     0.00700%     0.00700%        
                                                   CONTROL      3 SSAC                     3 SSAC                    3 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           10           60           10           60           10           
  Scheduled Sacrifice                                 10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Natural Death                                      4                         3                         6                        
    Moribund Sacrifice                                12                        24                        16                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                34                        23                        27                        
    Natural Death                                                                                          1                        
  Animals Examined Microscopically                    60           10           60                        60            3           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (53)         (9)          (50)                      (47)                      
      Papilloma                                                                  1 (2%)                                             
   Intestine Small, Ileum                             (58)         (10)         (49)                      (48)                      
      Carcinoma                                        1 (2%)                    1 (2%)                                             
   Intestine Small, Jejunum                           (59)         (10)         (50)                      (50)                      
      Carcinoma                                                                  2 (4%)                    1 (2%)                   
      Hemangiosarcoma                                                            1 (2%)                                             
   Liver                                              (60)         (10)         (51)                      (50)                      
      Carcinoma, Metastatic, Islets, Pancreatic                                                            1 (2%)                   
      Hemangioma                                                                 1 (2%)                                             
      Hemangiosarcoma                                  1 (2%)                    1 (2%)                    2 (4%)                   
      Hemangiosarcoma, Metastatic                                                                          1 (2%)                   
      Hepatoblastoma                                   1 (2%)                                              2 (4%)                   
      Hepatocellular Carcinoma                        11 (18%)                  14 (27%)                  10 (20%)                  
      Hepatocellular Carcinoma, Multiple, Two          2 (3%)                    2 (4%)                    3 (6%)                   
      Hepatocellular Carcinoma, Multiple, Three        1 (2%)                                                                       
      Hepatocellular Adenoma                           9 (15%)                  15 (29%)                  15 (30%)                  
      Hepatocellular Adenoma, Multiple, Two           12 (20%)                  10 (20%)                  10 (20%)                  
      Hepatocellular Adenoma, Multiple, Three          9 (15%)                   7 (14%)                   2 (4%)                   
      Hepatocellular Adenoma, Multiple, Four           2 (3%)                    2 (4%)                    1 (2%)                   
      Hepatocellular Adenoma, Multiple, Five                                                               1 (2%)                   
      Hepatocellular Adenoma, Multiple, Greater                                                                                     
          Than Five                                    1 (2%)                                                                       
      Histiocytic Sarcoma                                                                                  1 (2%)                   
      Sarcoma                                          1 (2%)                                                                       
   Mesentery                                          (9)          (1)          (7)                       (3)                       
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (14%)                                            
      Fibrosarcoma, Metastatic, Skeletal Muscle        1 (11%)                                                                      
      Hemangioma                                                                 1 (14%)                                            
                                                             Page  16                                                               
NTP Experiment-Test: 05089-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      VEHICLE      0.00500%     0.00500%     0.00700%     0.00700%        
                                                   CONTROL      3 SSAC                     3 SSAC                    3 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Hepatoblastoma, Metastatic, Liver                1 (11%)                                                                      
   Salivary Glands                                    (60)         (10)         (50)                      (50)                      
      Sarcoma                                          1 (2%)                                                                       
   Stomach, Forestomach                               (60)         (10)         (48)                      (50)                      
      Hepatoblastoma, Metastatic, Liver                1 (2%)                                                                       
      Squamous Cell Papilloma                          2 (3%)                                              1 (2%)                   
   Stomach, Glandular                                 (60)         (10)         (48)                      (50)                      
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (10)         (50)                      (50)                      
      Hemangiosarcoma                                                            1 (2%)                                             
      Sarcoma                                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (10)         (50)                      (50)                      
      Hepatoblastoma, Metastatic, Liver                1 (2%)                                                                       
      Capsule, Adenoma                                 5 (8%)                    4 (8%)                    4 (8%)                   
   Adrenal Gland, Medulla                             (59)         (10)         (50)                      (50)                      
      Neuroblastoma Benign                                                                                 1 (2%)                   
      Pheochromocytoma Benign                          1 (2%)                                              1 (2%)                   
   Islets, Pancreatic                                 (60)         (10)         (50)                      (50)                      
      Adenoma                                                                    1 (2%)                    1 (2%)                   
      Carcinoma                                                                                            1 (2%)                   
   Thyroid Gland                                      (60)         (10)         (49)                      (50)                      
      Follicular Cell, Adenoma                         1 (2%)                    2 (4%)                    1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                   (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (9)          (50)                      (50)                      
   Testes                                             (60)         (10)         (50)                      (50)                      
      Hemangioma                                                                 1 (2%)                                             
      Interstitial Cell, Adenoma                       1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  17                                                               
NTP Experiment-Test: 05089-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      VEHICLE      0.00500%     0.00500%     0.00700%     0.00700%        
                                                   CONTROL      3 SSAC                     3 SSAC                    3 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (10)         (50)                      (50)                      
      Hemangiosarcoma                                  1 (2%)                    1 (2%)                                             
      Histiocytic Sarcoma                                                                                  1 (2%)                   
   Lymph Node                                         (60)         (10)         (50)                      (50)                      
      Inguinal, Renal, Popliteal, Sarcoma              1 (2%)                                                                       
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                      1 (2%)                                             
      Mediastinal, Hepatoblastoma, Metastatic,                                                                                      
           Liver                                       1 (2%)                                                                       
      Mediastinal, Hepatocellular Carcinoma,                                                                                        
          Metastatic, Liver                            1 (2%)                                              1 (2%)                   
   Lymph Node, Mandibular                             (58)         (10)         (46)                      (48)                      
      Carcinoma, Metastatic, Harderian Gland                                                               1 (2%)                   
   Lymph Node, Mesenteric                             (56)         (10)         (50)                      (48)                      
      Hemangiosarcoma                                                                                      1 (2%)                   
      Histiocytic Sarcoma                                                                                  1 (2%)                   
   Spleen                                             (60)         (10)         (50)                      (50)                      
      Hemangioma                                       1 (2%)                                                                       
      Hemangiosarcoma                                  3 (5%)                                              2 (4%)                   
      Hepatoblastoma, Metastatic, Liver                1 (2%)                                                                       
      Histiocytic Sarcoma                                                                                  1 (2%)                   
   Thymus                                             (56)         (9)          (41)                      (43)                      
      Hemangioma                                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (10)         (50)                      (49)                      
      Subcutaneous Tissue, Fibrosarcoma                                                                    1 (2%)                   
      Subcutaneous Tissue, Hemangiosarcoma                                       1 (2%)                                             
      Subcutaneous Tissue, Melanoma Malignant                                                              1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (3)                                                                           
      Fibrosarcoma                                     1 (33%)                                                                      
      Hepatoblastoma, Metastatic, Liver                1 (33%)                                                                      
      Sarcoma                                          1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  18                                                               
NTP Experiment-Test: 05089-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      VEHICLE      0.00500%     0.00500%     0.00700%     0.00700%        
                                                   CONTROL      3 SSAC                     3 SSAC                    3 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (10)         (53)                      (50)                      
      Alveolar/Bronchiolar Adenoma                    16 (27%)                  10 (19%)                   8 (16%)                  
      Alveolar/Bronchiolar Adenoma, Multiple, Two      2 (3%)                    2 (4%)                    2 (4%)                   
      Alveolar/Bronchiolar Carcinoma                   9 (15%)                   7 (13%)                   2 (4%)                   
      Alveolar/Bronchiolar Carcinoma, Multiple, Two                              2 (4%)                                             
      Carcinoma, Metastatic, Harderian Gland                                                               1 (2%)                   
      Fibrosarcoma, Metastatic, Skeletal Muscle        1 (2%)                                                                       
      Hepatoblastoma, Metastatic, Liver                1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      3 (5%)                    3 (6%)                    2 (4%)                   
      Sarcoma                                          1 (2%)                                                                       
      Mediastinum, Hemangioma                          1 (2%)                    1 (2%)                                             
   Nose                                               (60)         (10)         (50)                      (50)                      
      Carcinoma, Metastatic, Harderian Gland                                                               1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (3)                       (1)                       (5)                       
      Adenoma                                          3 (100%)                  1 (100%)                  3 (60%)                  
      Carcinoma                                                                                            1 (20%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (10)         (60)                      (60)         (3)          
      Hepatoblastoma, Metastatic, Liver                1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver                                                          1 (2%)                   
      Sarcoma                                          1 (2%)                                                                       
   Urinary Bladder                                    (60)         (10)         (51)                      (50)                      
      Hemangioma                                                                 1 (2%)                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(10)        *(60)                     *(60)        *(3)          
      Histiocytic Sarcoma                                                                                  1 (2%)                   
      Lymphoma Malignant Lymphocytic                                             2 (3%)                                             
      Lymphoma Malignant Mixed                                                   3 (5%)                    3 (5%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  19                                                               
NTP Experiment-Test: 05089-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      VEHICLE      0.00500%     0.00500%     0.00700%     0.00700%        
                                                   CONTROL      3 SSAC                     3 SSAC                    3 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49                      52                      45                           
     Total Primary Neoplasms                          105                      99                      82                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 45                      41                      35                           
     Total Benign Neoplasms                            67                      61                      51                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              25                      29                      26                           
     Total Malignant Neoplasms                         38                      38                      31                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4                       4                       5                           
     Total Metastatic Neoplasm                         14                       6                       9                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  20                                                               
NTP Experiment-Test: 05089-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0100%      0.0100%      0.0140%      0.0140%      0.0200%      0.0200%         
                                                                3 SSAC                    3 SSAC                    3 SSAC          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           10           60           10           60           10           
  Scheduled Sacrifice                                 10           10           10           10            9           10           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                13                        13                        10                        
    Natural Death                                      3                         2                         4                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                34                        35                        37                        
  Animals Examined Microscopically                    60            2           60            1           60           10           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Ileum                             (48)                      (49)                      (58)         (10)         
   Intestine Small, Jejunum                           (50)                      (50)                      (57)         (10)         
      Carcinoma                                        3 (6%)                                              2 (4%)                   
   Liver                                              (52)                      (55)                      (60)         (10)         
      Hemangiosarcoma                                  4 (8%)                    2 (4%)                    2 (3%)                   
      Hepatoblastoma                                                                                       1 (2%)                   
      Hepatocellular Carcinoma                        15 (29%)                  14 (25%)                  10 (17%)                  
      Hepatocellular Carcinoma, Multiple, Two          1 (2%)                    2 (4%)                    1 (2%)                   
      Hepatocellular Adenoma                          14 (27%)                  11 (20%)                  13 (22%)                  
      Hepatocellular Adenoma, Multiple, Two            1 (2%)                   11 (20%)                   6 (10%)                  
      Hepatocellular Adenoma, Multiple, Three          5 (10%)                   4 (7%)                    1 (2%)                   
      Hepatocellular Adenoma, Multiple, Four           1 (2%)                    2 (4%)                    1 (2%)                   
      Hepatocellular Adenoma, Multiple, Five           1 (2%)                                                                       
      Hepatocellular Adenoma, Multiple, Greater                                                                                     
          Than Five                                    1 (2%)                                                                       
   Mesentery                                          (2)                       (4)                       (4)                       
      Hemangiosarcoma                                                            1 (25%)                                            
   Stomach, Forestomach                               (50)                      (50)                      (60)         (10)         
      Squamous Cell Papilloma                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)                      (50)                      (60)         (10)         
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  21                                                               
NTP Experiment-Test: 05089-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0100%      0.0100%      0.0140%      0.0140%      0.0200%      0.0200%         
                                                                3 SSAC                    3 SSAC                    3 SSAC          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)                      (50)                      (60)         (10)         
      Adenoma                                                                    1 (2%)                                             
      Capsule, Adenoma                                 4 (8%)                    1 (2%)                    1 (2%)                   
   Adrenal Gland, Medulla                             (50)                      (50)                      (60)         (10)         
      Pheochromocytoma Benign                          1 (2%)                                              1 (2%)                   
   Islets, Pancreatic                                 (50)                      (50)                      (60)         (10)         
      Adenoma                                          1 (2%)                                                                       
   Thyroid Gland                                      (49)                      (50)                      (59)         (10)         
      C-Cell, Carcinoma                                                          1 (2%)                                             
      Follicular Cell, Adenoma                         1 (2%)                    2 (4%)                    3 (5%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)                      (50)                      (60)         (10)         
   Prostate                                           (51)                      (50)                      (60)         (10)         
   Testes                                             (50)                      (50)                      (60)         (10)         
      Interstitial Cell, Adenoma                       2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)                      (50)                      (60)         (10)         
      Carcinoma, Metastatic, Thyroid Gland                                       1 (2%)                                             
      Hemangiosarcoma                                  1 (2%)                                                                       
   Lymph Node                                         (50)                      (50)                      (60)         (10)         
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                            1 (2%)                                                                       
      Mediastinal, Hepatocellular Carcinoma,                                                                                        
          Metastatic, Liver                                                                                1 (2%)                   
   Lymph Node, Mesenteric                             (50)                      (50)                      (59)         (10)         
   Spleen                                             (51)                      (51)                      (60)         (10)         
      Hemangioma                                                                 1 (2%)                                             
      Hemangiosarcoma                                  1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  22                                                               
NTP Experiment-Test: 05089-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0100%      0.0100%      0.0140%      0.0140%      0.0200%      0.0200%         
                                                                3 SSAC                    3 SSAC                    3 SSAC          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)                      (50)                      (60)         (10)         
      Neoplasm NOS                                     1 (2%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                                                                    1 (2%)                   
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                    1 (2%)                                             
      Subcutaneous Tissue, Lipoma                      1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                                                        (1)                       
      Hemangiosarcoma                                                                                      1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (51)                      (52)                      (60)         (10)         
      Alveolar/Bronchiolar Adenoma                    10 (20%)                  16 (31%)                   6 (10%)                  
      Alveolar/Bronchiolar Adenoma, Multiple, Two      1 (2%)                    1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   7 (14%)                   5 (10%)                   3 (5%)                   
      Alveolar/Bronchiolar Carcinoma, Multiple,                                                                                     
           Three                                                                 1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      2 (4%)                    1 (2%)                    2 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)                       (4)                       (6)                       
      Adenoma                                          1 (100%)                  4 (100%)                  5 (83%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (2)          (60)         (1)          (60)         (10)         
      Hepatocellular Carcinoma, Metastatic, Liver                                                          1 (2%)                   
      Renal Tubule, Adenoma                                                                                2 (3%)                   
   Urinary Bladder                                    (50)                      (50)                      (60)         (10)         
                                                             Page  23                                                               
NTP Experiment-Test: 05089-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0100%      0.0100%      0.0140%      0.0140%      0.0200%      0.0200%         
                                                                3 SSAC                    3 SSAC                    3 SSAC          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(2)         *(60)        *(1)         *(60)        *(10)         
      Lymphoma Malignant Mixed                         3 (5%)                    2 (3%)                    2 (3%)                   
      Lymphoma Malignant Undifferentiated Cell                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  24                                                               
NTP Experiment-Test: 05089-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0100%      0.0100%      0.0140%      0.0140%      0.0200%      0.0200%         
                                                                3 SSAC                    3 SSAC                    3 SSAC          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            42                      50                      41                           
     Total Primary Neoplasms                           82                      87                      62                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 32                      40                      31                           
     Total Benign Neoplasms                            45                      55                      39                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              29                      24                      19                           
     Total Malignant Neoplasms                         36                      32                      23                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3                       2                       2                           
     Total Metastatic Neoplasm                          4                       2                       4                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                                                                           
     Total Uncertain Neoplasms                          1                                                                           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  25                                                               
NTP Experiment-Test: 05089-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0275%      0.0275%                                                             
                                                                3 SSAC                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           10                                                               
  Scheduled Sacrifice                                  9           10                                                               
  Early Deaths                                                                                                                      
    Natural Death                                      8                                                                            
    Moribund Sacrifice                                10                                                                            
    Accidently Killed                                  1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                32                                                                            
  Animals Examined Microscopically                    60           10                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Ileum                             (58)         (9)                                                              
      Carcinoma                                        1 (2%)                                                                       
   Intestine Small, Jejunum                           (58)         (10)                                                             
      Carcinoma                                        2 (3%)                                                                       
   Liver                                              (60)         (10)                                                             
      Hemangiosarcoma                                  1 (2%)                                                                       
      Hepatocellular Carcinoma                        11 (18%)                                                                      
      Hepatocellular Carcinoma, Multiple, Two          2 (3%)                                                                       
      Hepatocellular Carcinoma, Multiple, Three        2 (3%)                                                                       
      Hepatocellular Adenoma                          18 (30%)                                                                      
      Hepatocellular Adenoma, Multiple, Two            5 (8%)                                                                       
      Hepatocellular Adenoma, Multiple, Three          4 (7%)                                                                       
      Hepatocellular Adenoma, Multiple, Five           1 (2%)                                                                       
   Mesentery                                          (3)          (1)                                                              
   Pancreas                                           (60)         (10)                                                             
   Salivary Glands                                    (60)         (10)                                                             
   Stomach, Forestomach                               (59)         (10)                                                             
      Squamous Cell Carcinoma                          1 (2%)                                                                       
   Stomach, Glandular                                 (59)         (10)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                                                                           
      Hemangioma                                       1 (100%)                                                                     
   Heart                                              (60)         (10)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  26                                                               
NTP Experiment-Test: 05089-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0275%      0.0275%                                                             
                                                                3 SSAC                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (9)                                                              
      Adenoma                                          1 (2%)                                                                       
      Capsule, Adenoma                                 5 (8%)                                                                       
   Adrenal Gland, Medulla                             (60)         (9)                                                              
      Pheochromocytoma Malignant                       1 (2%)                                                                       
   Islets, Pancreatic                                 (60)         (10)                                                             
      Adenoma                                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (7)                                                                           
      Squamous Cell Carcinoma                          1 (14%)                                                                      
   Prostate                                           (60)         (10)                                                             
   Testes                                             (60)         (10)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (10)                                                             
   Lymph Node                                         (60)         (10)                                                             
      Mediastinal, Squamous Cell Carcinoma,                                                                                         
          Metastatic, Preputial Gland                  1 (2%)                                                                       
   Lymph Node, Mandibular                             (57)         (10)                                                             
   Lymph Node, Mesenteric                             (59)         (8)                                                              
   Spleen                                             (60)         (10)                                                             
      Hemangioma                                       1 (2%)                                                                       
   Thymus                                             (58)         (10)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (4)                                                                           
      Carcinoma                                        1 (25%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  27                                                               
NTP Experiment-Test: 05089-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0275%      0.0275%                                                             
                                                                3 SSAC                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)                                                                           
      Squamous Cell Carcinoma, Metastatic,                                                                                          
          Preputial Gland                              1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (10)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (10)                                                             
      Alveolar/Bronchiolar Adenoma                    15 (25%)                                                                      
      Alveolar/Bronchiolar Carcinoma                   7 (12%)                                                                      
      Alveolar/Bronchiolar Carcinoma, Multiple,                                                                                     
           Three                                       1 (2%)                                                                       
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic,                                                                                          
          Preputial Gland                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)                                                                           
      Carcinoma                                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (10)                                                             
      Renal Tubule, Adenoma                            1 (2%)                                                                       
      Renal Tubule, Carcinoma                          1 (2%)                                                                       
   Urinary Bladder                                    (60)         (10)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(10)                                                             
      Lymphoma Malignant Mixed                         4 (7%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  28                                                               
NTP Experiment-Test: 05089-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:07  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0.0275%      0.0275%                                                             
                                                                3 SSAC                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            52                                                                           
     Total Primary Neoplasms                           90                                                                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 38                                                                           
     Total Benign Neoplasms                            53                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              31                                                                           
     Total Malignant Neoplasms                         37                                                                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3                                                                           
     Total Metastatic Neoplasm                          5                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  29                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           

--multipart-boundary
Content-type: text/plain
Range: bytes 182298-182298/182298


--multipart-boundary--
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.