National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1192

TR 392 Rat Pathology Tables

NTP Experiment-Test: 05089-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/19/97
Route: DOSED WATER                                                                                                Time: 09:11:14




       Facility:  Southern Research Institute

       Chemical CAS #:  10599903

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Merge     001   001,002                  0 ppm
                               Merge     002   003,004                  0 ppm
                               Merge     003   015,016                  50 ppm
                               Merge     004   013,014                  50 ppm
                               Merge     005   009,010                  100 ppm
                               Merge     006   011,012                  100 ppm
                               Merge     007   005,006                  200 ppm
                               Merge     008   007,008                  200 ppm




























a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05089-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/19/97  
Route: DOSED WATER                                                                                                Time: 09:11:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 ppm        50 ppm       100 ppm      200 ppm                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          70           70           70           70                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                16           17           20           23                                     
    Natural Death                                      3            5            1            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                31           28           29           24                                     

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (50)         (50)         (50)                                   
   Intestine Large, Colon                             (50)         (50)         (50)         (50)                                   
   Intestine Large, Rectum                            (50)         (50)         (50)         (50)                                   
   Intestine Small, Duodenum                          (50)         (50)         (49)         (50)                                   
   Intestine Small, Ileum                             (50)         (49)         (49)         (50)                                   
   Intestine Small, Jejunum                           (50)         (50)         (49)         (50)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hepatocellular Adenoma                           1 (2%)       3 (6%)       1 (2%)       3 (6%)                                
   Mesentery                                          (10)         (11)         (5)          (9)                                    
   Pancreas                                           (50)         (50)         (49)         (50)                                   
   Salivary Glands                                    (49)         (50)         (50)         (50)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (49)                                   
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
   Tongue                                             (1)          (1)          (1)                                                 
      Squamous Cell Papilloma                          1 (100%)                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)         (50)                                   
      Adenoma                                                       1 (2%)       1 (2%)       1 (2%)                                
      Carcinoma                                                                  1 (2%)                                             
   Adrenal Gland, Medulla                             (50)         (49)         (50)         (50)                                   
      Pheochromocytoma Benign                          6 (12%)      2 (4%)       5 (10%)      5 (10%)                               
      Bilateral, Pheochromocytoma Benign               1 (2%)                    1 (2%)                                             
   Islets, Pancreatic                                 (50)         (50)         (49)         (50)                                   
      Adenoma                                                       4 (8%)       1 (2%)                                             
      Carcinoma                                                     1 (2%)                                                          

                                                             Page   2                                                               
NTP Experiment-Test: 05089-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/19/97  
Route: DOSED WATER                                                                                                Time: 09:11:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 ppm        50 ppm       100 ppm      200 ppm                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Pituitary Gland                                    (50)         (49)         (50)         (50)                                   
      Pars Distalis, Adenoma                          33 (66%)     29 (59%)     18 (36%)     31 (62%)                               
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      C-Cell, Adenoma                                  4 (8%)       4 (8%)       4 (8%)       3 (6%)                                
      C-Cell, Carcinoma                                1 (2%)       2 (4%)       2 (4%)                                             
      Follicular Cell, Adenoma                         3 (6%)       1 (2%)       2 (4%)       1 (2%)                                
      Follicular Cell, Carcinoma                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (2)                                                              
      Oral, Squamous Cell Carcinoma                    1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)         (50)         (50)         (49)                                   
      Adenoma                                          5 (10%)      8 (16%)      7 (14%)      2 (4%)                                
      Carcinoma                                        1 (2%)       1 (2%)                    1 (2%)                                
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Granulosa Cell Tumor NOS                                                   1 (2%)                                             
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Adenoma                                                                    1 (2%)       1 (2%)                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Endometrium, Deciduoma NOS                                                 1 (2%)                                             
      Endometrium, Polyp Stromal                      10 (20%)      9 (18%)     12 (24%)     11 (22%)                               
      Endometrium, Sarcoma Stromal                                  1 (2%)       3 (6%)       1 (2%)                                
   Vagina                                             (8)          (7)          (11)         (12)                                   
      Sarcoma                                          1 (13%)                   1 (9%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
   Lymph Node                                         (50)         (50)         (50)         (50)                                   
   Lymph Node, Mandibular                             (48)         (49)         (49)         (49)                                   
      Carcinoma, Metastatic, Thyroid Gland                                       1 (2%)                                             
   Lymph Node, Mesenteric                             (49)         (50)         (50)         (50)                                   
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Hemangiosarcoma                                                                         1 (2%)                                
   Thymus                                             (49)         (47)         (49)         (49)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   3                                                               
NTP Experiment-Test: 05089-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/19/97  
Route: DOSED WATER                                                                                                Time: 09:11:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 ppm        50 ppm       100 ppm      200 ppm                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Adenocarcinoma                                   2 (4%)       1 (2%)       1 (2%)                                             
      Adenoma                                          1 (2%)                                 1 (2%)                                
      Fibroadenoma                                    11 (22%)     15 (30%)     13 (26%)     13 (26%)                               
      Fibroadenoma, Multiple                           5 (10%)      5 (10%)      6 (12%)      2 (4%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Squamous Cell Papilloma                                       1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                     2 (4%)                    1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                                 1 (2%)                                
      Subcutaneous Tissue, Lipoma                                                             1 (2%)                                
      Subcutaneous Tissue, Sarcoma                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (48)         (50)         (49)         (50)                                   
      Glioma Malignant                                                           1 (2%)                                             
      Glioma NOS                                                                              1 (2%)                                
      Oligodendroglioma NOS                                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)       1 (2%)       2 (4%)       3 (6%)                                
      Carcinoma, Multiple, Metastatic, Greater                                                                                      
          Than Five, Thyroid Gland                                               2 (4%)                                             
   Nose                                               (50)         (50)         (50)         (50)                                   
      Glands, Carcinoma                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)          (1)          (1)                                                 
      Pinna, Schwannoma NOS                            1 (100%)     1 (100%)     1 (100%)                                           
   Eye                                                (3)          (1)          (5)          (6)                                    
      Lids, Schwannoma NOS                                                       1 (20%)                                            
   Zymbal's Gland                                     (1)                                                                           
      Adenoma                                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________

                                                             Page   4                                                               
NTP Experiment-Test: 05089-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/19/97  
Route: DOSED WATER                                                                                                Time: 09:11:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 ppm        50 ppm       100 ppm      200 ppm                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Lipoma                                                                                  1 (2%)                                
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Leukemia Mononuclear                             8 (16%)     11 (22%)     15 (30%)     16 (32%)                               
      Lymphoma Malignant Lymphocytic                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   5                                                               
NTP Experiment-Test: 05089-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/19/97  
Route: DOSED WATER                                                                                                Time: 09:11:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 ppm        50 ppm       100 ppm      200 ppm                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            48          45          44          47                                       
     Total Primary Neoplasms                          104         103         105         101                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 45          42          37          44                                       
     Total Benign Neoplasms                            85          83          76          79                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              16          15          22          19                                       
     Total Malignant Neoplasms                         18          18          25          21                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                      2                                                   
     Total Metastatic Neoplasm                                                  3                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1           2           4           1                                       
     Total Uncertain Neoplasms                          1           2           4           1                                       
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   6                                                               
NTP Experiment-Test: 05089-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/19/97  
Route: DOSED WATER                                                                                                Time: 09:11:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 ppm        50 ppm       100 ppm      200 ppm                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          70           70           70           70                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                34           27           34           33                                     
    Natural Death                                      3            1            3            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                14           22           14           16                                     

  Animals Examined Microscopically                    51           50           51           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (51)         (50)         (51)         (50)                                   
      Carcinoma, Metastatic, Thyroid Gland                                       1 (2%)                                             
   Intestine Large, Cecum                             (51)         (50)         (50)         (50)                                   
   Intestine Large, Colon                             (51)         (50)         (51)         (49)                                   
   Intestine Large, Rectum                            (51)         (50)         (50)         (49)                                   
      Adenocarcinoma                                   1 (2%)                                                                       
   Intestine Small, Ileum                             (51)         (50)         (51)         (49)                                   
   Intestine Small, Jejunum                           (51)         (50)         (51)         (49)                                   
      Adenocarcinoma                                   1 (2%)                                                                       
   Liver                                              (51)         (50)         (51)         (50)                                   
      Hepatocellular Adenoma                           2 (4%)       4 (8%)       2 (4%)                                             
   Mesentery                                          (31)         (15)         (15)         (24)                                   
      Osteosarcoma, Metastatic, Bone                   1 (3%)                                                                       
   Pancreas                                           (51)         (50)         (51)         (50)                                   
      Acinar Cell, Adenoma                             4 (8%)       5 (10%)      1 (2%)       2 (4%)                                
      Acinar Cell, Adenoma, Multiple                                1 (2%)                                                          
   Pharynx                                                                      (1)                                                 
      Palate, Squamous Cell Papilloma                                            1 (100%)                                           
   Salivary Glands                                    (51)         (50)         (51)         (50)                                   
   Stomach, Forestomach                               (51)         (50)         (51)         (49)                                   
      Squamous Cell Papilloma                                                    1 (2%)                                             
   Stomach, Glandular                                 (51)         (50)         (51)         (49)                                   
   Tongue                                                                       (1)                                                 
      Squamous Cell Papilloma                                                    1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (51)         (50)         (51)         (50)                                   
      Schwannoma Malignant                                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   7                                                               
NTP Experiment-Test: 05089-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/19/97  
Route: DOSED WATER                                                                                                Time: 09:11:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 ppm        50 ppm       100 ppm      200 ppm                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (51)         (50)         (51)         (50)                                   
      Adenoma                                                                    1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
   Adrenal Gland, Medulla                             (51)         (50)         (51)         (50)                                   
      Pheochromocytoma Malignant                       2 (4%)                                                                       
      Pheochromocytoma Benign                         11 (22%)     16 (32%)     17 (33%)     14 (28%)                               
      Bilateral, Pheochromocytoma Benign              12 (24%)     19 (38%)     10 (20%)      8 (16%)                               
   Islets, Pancreatic                                 (51)         (50)         (51)         (50)                                   
      Adenoma                                          5 (10%)      5 (10%)      5 (10%)     10 (20%)                               
      Carcinoma                                        2 (4%)                    1 (2%)       1 (2%)                                
   Pituitary Gland                                    (50)         (50)         (51)         (50)                                   
      Pars Distalis, Adenoma                          20 (40%)     29 (58%)     22 (43%)     19 (38%)                               
   Thyroid Gland                                      (51)         (50)         (51)         (50)                                   
      C-Cell, Adenoma                                  6 (12%)      2 (4%)       3 (6%)       3 (6%)                                
      C-Cell, Carcinoma                                1 (2%)       2 (4%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (51)         (50)         (51)         (50)                                   
   Preputial Gland                                    (50)         (50)         (51)         (50)                                   
      Adenoma                                          3 (6%)       2 (4%)       4 (8%)       1 (2%)                                
      Carcinoma                                        1 (2%)       2 (4%)       3 (6%)       1 (2%)                                
      Sarcoma, Metastatic                                                                     1 (2%)                                
      Bilateral, Carcinoma                                                       1 (2%)                                             
   Prostate                                           (51)         (50)         (51)         (50)                                   
      Sarcoma, Metastatic                                                                     1 (2%)                                
   Seminal Vesicle                                    (51)         (50)         (51)         (50)                                   
   Testes                                             (51)         (50)         (51)         (50)                                   
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
      Bilateral, Interstitial Cell, Adenoma           26 (51%)     30 (60%)     30 (59%)     32 (64%)                               
      Interstitial Cell, Adenoma                       7 (14%)     14 (28%)      8 (16%)     11 (22%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (51)         (50)         (51)         (50)                                   
   Lymph Node                                         (51)         (50)         (51)         (50)                                   
   Lymph Node, Mandibular                             (51)         (50)         (51)         (49)                                   
   Lymph Node, Mesenteric                             (51)         (49)         (51)         (50)                                   
   Spleen                                             (51)         (50)         (51)         (50)                                   

                                                             Page   8                                                               
NTP Experiment-Test: 05089-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/19/97  
Route: DOSED WATER                                                                                                Time: 09:11:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 ppm        50 ppm       100 ppm      200 ppm                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
      Sarcoma                                                       1 (2%)                                                          
   Thymus                                             (46)         (46)         (48)         (49)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (48)         (49)         (49)                                   
      Adenocarcinoma                                                             1 (2%)                                             
      Adenoma                                          1 (2%)                                                                       
      Fibroadenoma                                     2 (4%)       1 (2%)       1 (2%)       2 (4%)                                
   Skin                                               (51)         (50)         (51)         (50)                                   
      Basal Cell Adenoma                                                         1 (2%)                                             
      Keratoacanthoma                                  3 (6%)       3 (6%)       2 (4%)       2 (4%)                                
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Squamous Cell Papilloma                          1 (2%)       3 (6%)       1 (2%)       1 (2%)                                
      Trichoepithelioma                                             1 (2%)                    1 (2%)                                
      Subcutaneous Tissue, Fibroma                                  4 (8%)       2 (4%)       5 (10%)                               
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                                                                       
      Subcutaneous Tissue, Fibrous Histiocytoma                                                                                     
          Malignant                                                                           1 (2%)                                
      Subcutaneous Tissue, Lipoma                      1 (2%)                                                                       
      Subcutaneous Tissue, Lymphangiosarcoma                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (51)         (50)         (51)         (50)                                   
      Osteosarcoma                                     1 (2%)                                                                       
   Skeletal Muscle                                                              (1)          (1)                                    
      Hindlimb, Sarcoma, Metastatic                                                           1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (51)         (50)         (51)         (50)                                   
      Glioma Malignant                                 1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                                                       (1)                                                 
      Carcinoma, Metastatic, Thyroid Gland                                       1 (100%)                                           
   Lung                                               (51)         (50)         (51)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)       4 (8%)                    2 (4%)                                
      Alveolar/Bronchiolar Carcinoma                                1 (2%)                    2 (4%)                                

                                                             Page   9                                                               
NTP Experiment-Test: 05089-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/19/97  
Route: DOSED WATER                                                                                                Time: 09:11:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 ppm        50 ppm       100 ppm      200 ppm                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Carcinoma, Metastatic, Thyroid Gland                                       1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
      Mediastinum, Osteosarcoma, Metastatic, Bone      1 (2%)                                                                       
   Nose                                               (51)         (50)         (51)         (50)                                   
   Trachea                                            (51)         (50)         (51)         (50)                                   
      Carcinoma, Metastatic, Thyroid Gland                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)          (2)                                                              
      Pinna, Squamous Cell Papilloma                                1 (50%)                                                         
   Zymbal's Gland                                     (1)                                    (1)                                    
      Carcinoma                                        1 (100%)                               1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (51)         (50)         (51)         (50)                                   
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
      Renal Tubule, Adenoma                                                      1 (2%)                                             
   Urinary Bladder                                    (51)         (50)         (51)         (50)                                   
      Sarcoma, Metastatic                                                                     1 (2%)                                
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(51)        *(50)        *(51)        *(50)                                   
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
      Leukemia Mononuclear                            25 (49%)     26 (52%)     29 (57%)     30 (60%)                               
      Mesothelioma Malignant                           1 (2%)                    2 (4%)       1 (2%)                                
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  10                                                               
NTP Experiment-Test: 05089-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/19/97  
Route: DOSED WATER                                                                                                Time: 09:11:14  
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         FISCHER 344 RATS MALE                     0 ppm        50 ppm       100 ppm      200 ppm                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          50          51          50                                       
     Total Primary Neoplasms                          144         176         154         152                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 47          50          50          49                                       
     Total Benign Neoplasms                           105         144         114         113                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              31          28          37          36                                       
     Total Malignant Neoplasms                         39          32          40          39                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1                       1           1                                       
     Total Metastatic Neoplasm                          7                       4           4                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.