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TR 392 Rat Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                    CHLORAMINE                                      DATE: 05/07/97       
EXPERIMENT: 05089 TEST: 01                                                                                     TIME: 15:41:49       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-45037                              ROUTE: DOSED WATER                                             NTP C#: C91004       
PATHOLOGIST: D. FARNELL                                                                                       CAS: 10599903        
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    25019 Moribund Sacrifice                                                                     
                                       25020 Natural Death                                                                          
                                       25021 Terminal Sacrifice                                                                     
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       EXCLUDE 017    0.0275%                                                                       
                                       EXCLUDE 018    0.0275% 3 SSAC                                                                
                                       EXCLUDE 019    0.0275%                                                                       
                                       EXCLUDE 020    0.0275% 3 SSAC                                                                
                                       EXCLUDE 021    0.0140%                                                                       
                                       EXCLUDE 022    0.0140% 3 SSAC                                                                
                                       EXCLUDE 023    0.0140%                                                                       
                                       EXCLUDE 024    0.0140% 3 SSAC                                                                
                                       EXCLUDE 025    0.00700%                                                                      
                                       EXCLUDE 026    0.00700% 3 SSAC                                                               
                                       EXCLUDE 027    0.00700%                                                                      
                                       EXCLUDE 028    0.00700% 3 SSAC                                                               
                                       EXCLUDE 029    SENTINEL                                                                      
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                    CHLORAMINE                                      DATE: 05/07/97       
EXPERIMENT: 05089 TEST: 01                                                                                     TIME: 15:41:49       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-45037                              ROUTE: DOSED WATER                                             NTP C#: C91004       
PATHOLOGIST: D. FARNELL                                                                                        CAS: 10599903        


                                                    RATS(FISCHER 344)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                                    
                                                    ----------------
                                                    Adrenal Gland
                                                    Adrenal Medulla
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Clitoral/Preputial Gland
                                                    Epididymis
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Larynx
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Southern Research Inst                                    CHLORAMINE                                      DATE: 05/07/97       
EXPERIMENT: 05089 TEST: 01                                                                                     TIME: 15:41:49       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-45037                              ROUTE: DOSED WATER                                             NTP C#: C91004       
PATHOLOGIST: D. FARNELL                                                                                        CAS: 10599903        


                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                           IN THE ANALYSIS OF THE STUDY OF CHLORAMINE
              ====================================================================================================
                                                           MALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Adrenal Medulla               Pheochromocytoma Benign
                                            Pheochromocytoma: Benign, Complex, Malignant, NOS
              Pituitary Gland: Pars Distalis or Unspecified Site
                                            Adenoma
              Skin                          Fibroma
                                            Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma
              Testes                        Adenoma
              All Organs                    Malignant and Benign Tumors
              ====================================================================================================
                                                           FEMALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Islets, Pancreatic            Carcinoma or Adenoma
              Pituitary Gland: Pars Distalis or Unspecified Site
                                            Adenoma
              All Organs                    Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
                                            Benign Tumors
              ====================================================================================================
         DATE: 05/07/97                     EXPERIMENT: 05089 TEST: 01                                                 PAGE   1
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.00500%     0.0100%      0.0200%   |   VEHICLE      0.00500%     0.0100%      0.0200%   |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 23/51 (45%)  35/50 (70%)  27/51 (53%)  22/50 (44%) |  7/50 (14%)   2/49 (4%)    6/50 (12%)   5/50 (10%) |
|ADJUSTED (b)           |  84.2%        84.8%        79.8%        72.6%      |  21.9%         7.4%        16.3%        16.8%      |
|TERMINAL (d)           | 10/14 (71%)  16/22 (73%)   8/14 (57%)   9/16 (56%) |  6/31 (19%)   2/27 (7%)    2/29 (7%)    2/24 (8%)  |
|FIRST INCIDENCE (DAYS) |   541          605          533          543       |   721          729 (T)      584          687       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.231N     P=0.446      P=0.325      P=0.300N   |  P=0.517      P=0.114N     P=0.537N     P=0.526N   |
|INCIDENTAL TUMOR       |  P=0.086N     P=0.140      P=0.362      P=0.269N   |  P=0.518N     P=0.111N     P=0.542N     P=0.447N   |
|LOGISTIC REGRESSION    |  P=0.098N     P=0.111      P=0.343      P=0.275N   |  P=0.531N     P=0.092N     P=0.526N     P=0.451N   |
|COCHRAN-ARMITAGE       |  P=0.210N                                          |  P=0.495N                                          |
|FISHER EXACT           |               P=0.010 **   P=0.276      P=0.536N   |               P=0.085N     P=0.500N     P=0.380N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Malignant                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/51 (4%)    0/50 (0%)    0/51 (0%)    0/50 (0%)  |  0/50 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   8.5%         0.0%         0.0%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/14 (0%)    0/22 (0%)    0/14 (0%)    0/16 (0%)  |  0/31 (0%)    0/27 (0%)    0/29 (0%)    0/24 (0%)  |
|FIRST INCIDENCE (DAYS) |   675          ---          ---          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.113N     P=0.187N     P=0.235N     P=0.222N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.096N     P=0.197N     P=0.222N     P=0.176N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.110N     P=0.205N     P=0.229N     P=0.216N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.116N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.252N     P=0.248N     P=0.252N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 05/07/97                     EXPERIMENT: 05089 TEST: 01                                                 PAGE   2
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.00500%     0.0100%      0.0200%   |   VEHICLE      0.00500%     0.0100%      0.0200%   |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 25/51 (49%)  35/50 (70%)  27/51 (53%)  22/50 (44%) |  7/50 (14%)   2/49 (4%)    6/50 (12%)   5/50 (10%) |
|ADJUSTED (b)           |  85.5%        84.8%        79.8%        72.6%      |  21.9%         7.4%        16.3%        16.8%      |
|TERMINAL (d)           | 10/14 (71%)  16/22 (73%)   8/14 (57%)   9/16 (56%) |  6/31 (19%)   2/27 (7%)    2/29 (7%)    2/24 (8%)  |
|FIRST INCIDENCE (DAYS) |   541          605          533          543       |   721          729 (T)      584          687       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.160N     P=0.537N     P=0.450      P=0.194N   |  P=0.517      P=0.114N     P=0.537N     P=0.526N   |
|INCIDENTAL TUMOR       |  P=0.038N*    P=0.279      P=0.541      P=0.132N   |  P=0.518N     P=0.111N     P=0.542N     P=0.447N   |
|LOGISTIC REGRESSION    |  P=0.048N*    P=0.235      P=0.522      P=0.142N   |  P=0.531N     P=0.092N     P=0.526N     P=0.451N   |
|COCHRAN-ARMITAGE       |  P=0.127N                                          |  P=0.495N                                          |
|FISHER EXACT           |               P=0.026 *    P=0.422      P=0.380N   |               P=0.085N     P=0.500N     P=0.380N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    2/50 (4%)    4/51 (8%)    1/50 (2%)  |  5/48 (10%)   8/50 (16%)   7/50 (14%)   2/49 (4%)  |
|ADJUSTED (b)           |  14.5%         9.1%        22.3%         2.1%      |  16.1%        23.7%        22.7%         4.3%      |
|TERMINAL (d)           |  1/14 (7%)    2/22 (9%)    2/14 (14%)   0/16 (0%)  |  5/31 (16%)   4/28 (14%)   6/29 (21%)   0/24 (0%)  |
|FIRST INCIDENCE (DAYS) |   465          729 (T)      690          543       |   729 (T)      540          667          508       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.294N     P=0.344N     P=0.502      P=0.270N   |  P=0.208N     P=0.236      P=0.332      P=0.299N   |
|INCIDENTAL TUMOR       |  P=0.309N     P=0.504N     P=0.479      P=0.387N   |  P=0.141N     P=0.240      P=0.334      P=0.242N   |
|LOGISTIC REGRESSION    |  P=0.274N     P=0.462N     P=0.528      P=0.372N   |  P=0.129N     P=0.282      P=0.374      P=0.197N   |
|COCHRAN-ARMITAGE       |  P=0.290N                                          |  P=0.120N                                          |
|FISHER EXACT           |               P=0.500N     P=0.511      P=0.309N   |               P=0.304      P=0.409      P=0.209N   |
|=================================================================================================================================|
         DATE: 05/07/97                     EXPERIMENT: 05089 TEST: 01                                                 PAGE   3
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.00500%     0.0100%      0.0200%   |   VEHICLE      0.00500%     0.0100%      0.0200%   |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    2/50 (4%)    4/51 (8%)    1/50 (2%)  |  1/48 (2%)    1/50 (2%)    0/50 (0%)    1/49 (2%)  |
|ADJUSTED (b)           |   2.3%         7.2%         9.3%         6.3%      |   3.2%         2.1%         0.0%         3.3%      |
|TERMINAL (d)           |  0/14 (0%)    1/22 (5%)    0/14 (0%)    1/16 (6%)  |  1/31 (3%)    0/28 (0%)    0/29 (0%)    0/24 (0%)  |
|FIRST INCIDENCE (DAYS) |   537          661          519          729 (T)   |   729 (T)      452          ---          703       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.578N     P=0.597      P=0.202      P=0.738N   |  P=0.645N     P=0.744      P=0.513N     P=0.718    |
|INCIDENTAL TUMOR       |  P=0.560      P=0.381      P=0.182      P=0.703    |  P=0.570N     P=0.704      P=0.513N     P=0.754N   |
|LOGISTIC REGRESSION    |  P=0.522      P=0.458      P=0.112      P=0.748    |  P=0.609N     P=0.692N     P=0.513N     P=0.748    |
|COCHRAN-ARMITAGE       |  P=0.596N                                          |  P=0.614N                                          |
|FISHER EXACT           |               P=0.500      P=0.187      P=0.753N   |               P=0.742N     P=0.490N     P=0.747N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/50 (8%)    4/50 (8%)    8/51 (16%)   2/50 (4%)  |  6/48 (13%)   9/50 (18%)   7/50 (14%)   3/49 (6%)  |
|ADJUSTED (b)           |  16.4%        16.0%        29.6%         8.2%      |  19.4%        25.2%        22.7%         7.5%      |
|TERMINAL (d)           |  1/14 (7%)    3/22 (14%)   2/14 (14%)   1/16 (6%)  |  6/31 (19%)   4/28 (14%)   6/29 (21%)   0/24 (0%)  |
|FIRST INCIDENCE (DAYS) |   465          661          519          543       |   729 (T)      452          667          508       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.332N     P=0.458N     P=0.203      P=0.293N   |  P=0.220N     P=0.245      P=0.450      P=0.344N   |
|INCIDENTAL TUMOR       |  P=0.375N     P=0.583      P=0.175      P=0.451N   |  P=0.136N     P=0.229      P=0.451      P=0.263N   |
|LOGISTIC REGRESSION    |  P=0.355N     P=0.644N     P=0.175      P=0.410N   |  P=0.129N     P=0.308      P=0.498      P=0.229N   |
|COCHRAN-ARMITAGE       |  P=0.336N                                          |  P=0.125N                                          |
|FISHER EXACT           |               P=0.643N     P=0.188      P=0.339N   |               P=0.318      P=0.532      P=0.233N   |
|=================================================================================================================================|
         DATE: 05/07/97                     EXPERIMENT: 05089 TEST: 01                                                 PAGE   4
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.00500%     0.0100%      0.0200%   |   VEHICLE      0.00500%     0.0100%      0.0200%   |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/51 (10%)   5/50 (10%)   5/51 (10%)  10/50 (20%) |  0/50 (0%)    4/50 (8%)    1/49 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |  23.4%        18.5%        24.3%        40.3%      |   0.0%        12.2%         3.6%         0.0%      |
|TERMINAL (d)           |  2/14 (14%)   2/22 (9%)    2/14 (14%)   4/16 (25%) |  0/31 (0%)    2/28 (7%)    1/28 (4%)    0/24 (0%)  |
|FIRST INCIDENCE (DAYS) |   605          662          533          636       |   ---          662          729 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.070      P=0.412N     P=0.619N     P=0.201    |  P=0.348N     P=0.057      P=0.480        (e)      |
|INCIDENTAL TUMOR       |  P=0.091      P=0.473N     P=0.625N     P=0.216    |  P=0.312N     P=0.058      P=0.480        (e)      |
|LOGISTIC REGRESSION    |  P=0.079      P=0.504N     P=0.608N     P=0.183    |  P=0.312N     P=0.060      P=0.480        (e)      |
|COCHRAN-ARMITAGE       |  P=0.066                                           |  P=0.297N                                          |
|FISHER EXACT           |               P=0.617      P=0.630N     P=0.123    |               P=0.059      P=0.495        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/51 (4%)    0/50 (0%)    1/51 (2%)    1/50 (2%)  |  0/50 (0%)    1/50 (2%)    0/49 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |  10.2%         0.0%         2.2%         5.9%      |   0.0%         3.6%         0.0%         0.0%      |
|TERMINAL (d)           |  0/14 (0%)    0/22 (0%)    0/14 (0%)    0/16 (0%)  |  0/31 (0%)    1/28 (4%)    0/28 (0%)    0/24 (0%)  |
|FIRST INCIDENCE (DAYS) |   675          ---          562          719       |   ---          729 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.510N     P=0.179N     P=0.500N     P=0.484N   |  P=0.603N     P=0.480        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.449N     P=0.197N     P=0.452N     P=0.398N   |  P=0.603N     P=0.480        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.496N     P=0.190N     P=0.494N     P=0.456N   |  P=0.603N     P=0.480        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.504N                                          |  P=0.567N                                          |
|FISHER EXACT           |               P=0.252N     P=0.500N     P=0.508N   |               P=0.500        (e)          (e)      |
|=================================================================================================================================|
         DATE: 05/07/97                     EXPERIMENT: 05089 TEST: 01                                                 PAGE   5
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.00500%     0.0100%      0.0200%   |   VEHICLE      0.00500%     0.0100%      0.0200%   |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  7/51 (14%)   5/50 (10%)   6/51 (12%)  11/50 (22%) |  0/50 (0%)    5/50 (10%)   1/49 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |  31.2%        18.5%        25.9%        43.8%      |   0.0%        15.6%         3.6%         0.0%      |
|TERMINAL (d)           |  2/14 (14%)   2/22 (9%)    2/14 (14%)   4/16 (25%) |  0/31 (0%)    3/28 (11%)   1/28 (4%)    0/24 (0%)  |
|FIRST INCIDENCE (DAYS) |   605          662          533          636       |   ---          662          729 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.107      P=0.189N     P=0.493N     P=0.309    |  P=0.296N     P=0.029 *    P=0.480        (e)      |
|INCIDENTAL TUMOR       |  P=0.143      P=0.227N     P=0.471N     P=0.359    |  P=0.266N     P=0.029 *    P=0.480        (e)      |
|LOGISTIC REGRESSION    |  P=0.120      P=0.245N     P=0.472N     P=0.301    |  P=0.261N     P=0.031 *    P=0.480        (e)      |
|COCHRAN-ARMITAGE       |  P=0.099                                           |  P=0.243N                                          |
|FISHER EXACT           |               P=0.394N     P=0.500N     P=0.205    |               P=0.028 *    P=0.495        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/51 (4%)    4/50 (8%)    2/51 (4%)    0/50 (0%)  |  1/50 (2%)    3/50 (6%)    1/50 (2%)    3/50 (6%)  |
|ADJUSTED (b)           |  11.2%        15.9%        10.0%         0.0%      |   3.2%        10.7%         3.4%        12.5%      |
|TERMINAL (d)           |  1/14 (7%)    3/22 (14%)   1/14 (7%)    0/16 (0%)  |  1/31 (3%)    3/28 (11%)   1/29 (3%)    3/24 (13%) |
|FIRST INCIDENCE (DAYS) |   687          653          625          ---       |   729 (T)      729 (T)      729 (T)      729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.107N     P=0.526      P=0.688N     P=0.221N   |  P=0.223      P=0.268      P=0.747      P=0.217    |
|INCIDENTAL TUMOR       |  P=0.101N     P=0.512      P=0.662N     P=0.195N   |  P=0.223      P=0.268      P=0.747      P=0.217    |
|LOGISTIC REGRESSION    |  P=0.100N     P=0.457      P=0.684N     P=0.209N   |  P=0.222      P=0.268      P=0.747      P=0.217    |
|COCHRAN-ARMITAGE       |  P=0.114N                                          |  P=0.313                                           |
|FISHER EXACT           |               P=0.329      P=0.691N     P=0.252N   |               P=0.309      P=0.753N     P=0.309    |
|=================================================================================================================================|
         DATE: 05/07/97                     EXPERIMENT: 05089 TEST: 01                                                 PAGE   6
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.00500%     0.0100%      0.0200%   |   VEHICLE      0.00500%     0.0100%      0.0200%   |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/51 (2%)    4/50 (8%)    0/51 (0%)    2/50 (4%)  |  1/50 (2%)    1/50 (2%)    2/50 (4%)    3/50 (6%)  |
|ADJUSTED (b)           |   3.8%        13.7%         0.0%        11.2%      |   3.2%         3.6%         5.7%         9.7%      |
|TERMINAL (d)           |  0/14 (0%)    2/22 (9%)    0/14 (0%)    1/16 (6%)  |  1/31 (3%)    1/28 (4%)    1/29 (3%)    1/24 (4%)  |
|FIRST INCIDENCE (DAYS) |   674          618          ---          718       |   729 (T)      729 (T)      619          589       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.573N     P=0.293      P=0.500N     P=0.535    |  P=0.125      P=0.739      P=0.477      P=0.251    |
|INCIDENTAL TUMOR       |  P=0.546N     P=0.243      P=0.487N     P=0.582    |  P=0.171      P=0.739      P=0.548      P=0.328    |
|LOGISTIC REGRESSION    |  P=0.560N     P=0.212      P=0.493N     P=0.544    |  P=0.162      P=0.739      P=0.496      P=0.302    |
|COCHRAN-ARMITAGE       |  P=0.583N                                          |  P=0.165                                           |
|FISHER EXACT           |               P=0.175      P=0.500N     P=0.492    |               P=0.753N     P=0.500      P=0.309    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/51 (0%)    1/50 (2%)    0/51 (0%)    2/50 (4%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         4.5%         0.0%         5.9%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/14 (0%)    1/22 (5%)    0/14 (0%)    0/16 (0%)  |  0/31 (0%)    0/28 (0%)    0/29 (0%)    0/24 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          729 (T)      ---          577       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.140      P=0.590        (e)        P=0.267    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.145      P=0.590        (e)        P=0.250    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.137      P=0.590        (e)        P=0.196    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.137                                           |    (e)                                             |
|FISHER EXACT           |               P=0.495        (e)        P=0.243    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 05/07/97                     EXPERIMENT: 05089 TEST: 01                                                 PAGE   7
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.00500%     0.0100%      0.0200%   |   VEHICLE      0.00500%     0.0100%      0.0200%   |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/51 (2%)    4/50 (8%)    0/51 (0%)    4/50 (8%)  |  1/50 (2%)    1/50 (2%)    2/50 (4%)    3/50 (6%)  |
|ADJUSTED (b)           |   3.8%        13.7%         0.0%        16.5%      |   3.2%         3.6%         5.7%         9.7%      |
|TERMINAL (d)           |  0/14 (0%)    2/22 (9%)    0/14 (0%)    1/16 (6%)  |  1/31 (3%)    1/28 (4%)    1/29 (3%)    1/24 (4%)  |
|FIRST INCIDENCE (DAYS) |   674          618          ---          577       |   729 (T)      729 (T)      619          589       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.234      P=0.293      P=0.500N     P=0.220    |  P=0.125      P=0.739      P=0.477      P=0.251    |
|INCIDENTAL TUMOR       |  P=0.256      P=0.243      P=0.487N     P=0.232    |  P=0.171      P=0.739      P=0.548      P=0.328    |
|LOGISTIC REGRESSION    |  P=0.237      P=0.212      P=0.493N     P=0.197    |  P=0.162      P=0.739      P=0.496      P=0.302    |
|COCHRAN-ARMITAGE       |  P=0.222                                           |  P=0.165                                           |
|FISHER EXACT           |               P=0.175      P=0.500N     P=0.175    |               P=0.753N     P=0.500      P=0.309    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/51 (0%)    0/50 (0%)    1/51 (2%)    0/50 (0%)  |  2/50 (4%)    1/50 (2%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         5.6%         0.0%      |   6.5%         3.6%         3.4%         0.0%      |
|TERMINAL (d)           |  0/14 (0%)    0/22 (0%)    0/14 (0%)    0/16 (0%)  |  2/31 (6%)    1/28 (4%)    1/29 (3%)    0/24 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          703          ---       |   729 (T)      729 (T)      729 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.696        (e)        P=0.489        (e)      |  P=0.189N     P=0.536N     P=0.523N     P=0.296N   |
|INCIDENTAL TUMOR       |  P=0.721        (e)        P=0.513        (e)      |  P=0.189N     P=0.536N     P=0.523N     P=0.296N   |
|LOGISTIC REGRESSION    |  P=0.701        (e)        P=0.505        (e)      |  P=0.189N     P=0.536N     P=0.523N     P=0.296N   |
|COCHRAN-ARMITAGE       |  P=0.693                                           |  P=0.153N                                          |
|FISHER EXACT           |                 (e)        P=0.500        (e)      |               P=0.500N     P=0.500N     P=0.247N   |
|=================================================================================================================================|
         DATE: 05/07/97                     EXPERIMENT: 05089 TEST: 01                                                 PAGE   8
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.00500%     0.0100%      0.0200%   |   VEHICLE      0.00500%     0.0100%      0.0200%   |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/51 (2%)    0/50 (0%)    1/51 (2%)    0/50 (0%)  |  3/50 (6%)    1/50 (2%)    1/50 (2%)    1/50 (2%)  |
|ADJUSTED (b)           |   2.4%         0.0%         5.6%         0.0%      |   9.7%         3.6%         3.4%         3.0%      |
|TERMINAL (d)           |  0/14 (0%)    0/22 (0%)    0/14 (0%)    0/16 (0%)  |  3/31 (10%)   1/28 (4%)    1/29 (3%)    0/24 (0%)  |
|FIRST INCIDENCE (DAYS) |   541          ---          703          ---       |   729 (T)      729 (T)      729 (T)      690       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.397N     P=0.469N     P=0.756N     P=0.478N   |  P=0.299N     P=0.341N     P=0.328N     P=0.382N   |
|INCIDENTAL TUMOR       |  P=0.430N     P=0.892N     P=0.717      P=0.638N   |  P=0.285N     P=0.341N     P=0.328N     P=0.355N   |
|LOGISTIC REGRESSION    |  P=0.441N     P=0.691N     P=0.754      P=0.650N   |  P=0.269N     P=0.341N     P=0.328N     P=0.338N   |
|COCHRAN-ARMITAGE       |  P=0.408N                                          |  P=0.242N                                          |
|FISHER EXACT           |               P=0.505N     P=0.752N     P=0.505N   |               P=0.309N     P=0.309N     P=0.309N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/51 (4%)    1/50 (2%)    1/51 (2%)    2/50 (4%)  | 16/50 (32%)  20/50 (40%)  19/50 (38%)  15/50 (30%) |
|ADJUSTED (b)           |  14.3%         4.5%         7.1%         8.9%      |  43.5%        54.6%        55.0%        44.5%      |
|TERMINAL (d)           |  2/14 (14%)   1/22 (5%)    1/14 (7%)    1/16 (6%)  | 11/31 (35%)  12/28 (43%)  14/29 (48%)   7/24 (29%) |
|FIRST INCIDENCE (DAYS) |   729 (T)      729 (T)      729 (T)      656       |   578          626          584          465       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.554      P=0.342N     P=0.500N     P=0.639N   |  P=0.442      P=0.199      P=0.274      P=0.430    |
|INCIDENTAL TUMOR       |  P=0.560      P=0.342N     P=0.500N     P=0.633N   |  P=0.408N     P=0.226      P=0.286      P=0.528N   |
|LOGISTIC REGRESSION    |  P=0.563      P=0.342N     P=0.500N     P=0.652N   |  P=0.418N     P=0.229      P=0.284      P=0.536N   |
|COCHRAN-ARMITAGE       |  P=0.551                                           |  P=0.363N                                          |
|FISHER EXACT           |               P=0.508N     P=0.500N     P=0.684    |               P=0.266      P=0.338      P=0.500N   |
|=================================================================================================================================|
         DATE: 05/07/97                     EXPERIMENT: 05089 TEST: 01                                                 PAGE   9
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.00500%     0.0100%      0.0200%   |   VEHICLE      0.00500%     0.0100%      0.0200%   |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma or Adenoma                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/51 (6%)    1/50 (2%)    1/51 (2%)    2/50 (4%)  | 17/50 (34%)  20/50 (40%)  19/50 (38%)  16/50 (32%) |
|ADJUSTED (b)           |  16.3%         4.5%         7.1%         8.9%      |  46.3%        54.6%        55.0%        46.2%      |
|TERMINAL (d)           |  2/14 (14%)   1/22 (5%)    1/14 (7%)    1/16 (6%)  | 12/31 (39%)  12/28 (43%)  14/29 (48%)   7/24 (29%) |
|FIRST INCIDENCE (DAYS) |   541          729 (T)      729 (T)      656       |   578          626          584          465       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.473N     P=0.182N     P=0.295N     P=0.433N   |  P=0.418      P=0.254      P=0.343      P=0.420    |
|INCIDENTAL TUMOR       |  P=0.498N     P=0.306N     P=0.345N     P=0.498N   |  P=0.428N     P=0.291      P=0.360      P=0.529N   |
|LOGISTIC REGRESSION    |  P=0.456N     P=0.260N     P=0.291N     P=0.467N   |  P=0.440N     P=0.298      P=0.359      P=0.540N   |
|COCHRAN-ARMITAGE       |  P=0.479N                                          |  P=0.383N                                          |
|FISHER EXACT           |               P=0.316N     P=0.309N     P=0.509N   |               P=0.339      P=0.418      P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/51 (6%)    1/50 (2%)    2/51 (4%)    2/50 (4%)  | 19/50 (38%)  21/50 (42%)  19/50 (38%)  16/50 (32%) |
|ADJUSTED (b)           |  16.3%         4.5%        12.3%         8.9%      |  52.0%        57.5%        55.0%        46.2%      |
|TERMINAL (d)           |  2/14 (14%)   1/22 (5%)    1/14 (7%)    1/16 (6%)  | 14/31 (45%)  13/28 (46%)  14/29 (48%)   7/24 (29%) |
|FIRST INCIDENCE (DAYS) |   541          729 (T)      703          656       |   578          626          584          465       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.499N     P=0.182N     P=0.497N     P=0.433N   |  P=0.512N     P=0.310      P=0.493      P=0.554    |
|INCIDENTAL TUMOR       |  P=0.509N     P=0.306N     P=0.536N     P=0.498N   |  P=0.285N     P=0.356      P=0.521      P=0.384N   |
|LOGISTIC REGRESSION    |  P=0.481N     P=0.260N     P=0.483N     P=0.467N   |  P=0.287N     P=0.373      P=0.523      P=0.381N   |
|COCHRAN-ARMITAGE       |  P=0.506N                                          |  P=0.237N                                          |
|FISHER EXACT           |               P=0.316N     P=0.500N     P=0.509N   |               P=0.419      P=0.582N     P=0.338N   |
|=================================================================================================================================|
         DATE: 05/07/97                     EXPERIMENT: 05089 TEST: 01                                                 PAGE  10
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.00500%     0.0100%      0.0200%   |   VEHICLE      0.00500%     0.0100%      0.0200%   |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Papilloma Squamous or Papilloma                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/51 (0%)    0/50 (0%)    2/51 (4%)    0/50 (0%)  |  1/50 (2%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         4.5%         0.0%      |   3.2%         0.0%         3.4%         0.0%      |
|TERMINAL (d)           |  0/14 (0%)    0/22 (0%)    0/14 (0%)    0/16 (0%)  |  1/31 (3%)    0/28 (0%)    1/29 (3%)    0/24 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          447          ---       |   729 (T)      ---          729 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.606        (e)        P=0.247        (e)      |  P=0.451N     P=0.520N     P=0.747      P=0.551N   |
|INCIDENTAL TUMOR       |  P=0.542        (e)        P=0.217        (e)      |  P=0.451N     P=0.520N     P=0.747      P=0.551N   |
|LOGISTIC REGRESSION    |  P=0.386        (e)        P=0.127        (e)      |  P=0.451N     P=0.520N     P=0.747      P=0.551N   |
|COCHRAN-ARMITAGE       |  P=0.592                                           |  P=0.405N                                          |
|FISHER EXACT           |                 (e)        P=0.248        (e)      |               P=0.500N     P=0.753N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/51 (0%)    0/50 (0%)    2/51 (4%)    0/50 (0%)  |  1/50 (2%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         4.5%         0.0%      |   3.2%         0.0%         3.4%         0.0%      |
|TERMINAL (d)           |  0/14 (0%)    0/22 (0%)    0/14 (0%)    0/16 (0%)  |  1/31 (3%)    0/28 (0%)    1/29 (3%)    0/24 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          447          ---       |   729 (T)      ---          729 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.606        (e)        P=0.247        (e)      |  P=0.451N     P=0.520N     P=0.747      P=0.551N   |
|INCIDENTAL TUMOR       |  P=0.542        (e)        P=0.217        (e)      |  P=0.451N     P=0.520N     P=0.747      P=0.551N   |
|LOGISTIC REGRESSION    |  P=0.386        (e)        P=0.127        (e)      |  P=0.451N     P=0.520N     P=0.747      P=0.551N   |
|COCHRAN-ARMITAGE       |  P=0.592                                           |  P=0.405N                                          |
|FISHER EXACT           |                 (e)        P=0.248        (e)      |               P=0.500N     P=0.753N     P=0.500N   |
|=================================================================================================================================|
         DATE: 05/07/97                     EXPERIMENT: 05089 TEST: 01                                                 PAGE  11
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.00500%     0.0100%      0.0200%   |   VEHICLE      0.00500%     0.0100%      0.0200%   |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/51 (8%)    6/50 (12%)   1/51 (2%)    2/50 (4%)  |  0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |  25.6%        27.3%         7.1%        12.5%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  3/14 (21%)   6/22 (27%)   1/14 (7%)    2/16 (13%) |  0/31 (0%)    0/28 (0%)    0/28 (0%)    0/24 (0%)  |
|FIRST INCIDENCE (DAYS) |   710          729 (T)      729 (T)      729 (T)   |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.126N     P=0.626N     P=0.181N     P=0.274N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.121N     P=0.629N     P=0.170N     P=0.260N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.129N     P=0.586      P=0.182N     P=0.286N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.136N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.358      P=0.181N     P=0.348N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 20/50 (40%)  29/50 (58%)  22/51 (43%)  19/50 (38%) | 33/50 (66%)  29/49 (59%)  18/50 (36%)  31/50 (62%) |
|ADJUSTED (b)           |  58.7%        70.2%        69.0%        58.1%      |  78.1%        69.5%        46.0%        78.4%      |
|TERMINAL (d)           |  3/13 (23%)  11/22 (50%)   7/14 (50%)   5/16 (31%) | 22/31 (71%)  15/27 (56%)   9/29 (31%)  16/24 (67%) |
|FIRST INCIDENCE (DAYS) |   451          473          447          577       |   531          540          590          465       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.237N     P=0.502      P=0.493      P=0.321N   |  P=0.393      P=0.489N     P=0.017N*    P=0.331    |
|INCIDENTAL TUMOR       |  P=0.187N     P=0.046 *    P=0.530      P=0.434N   |  P=0.303N     P=0.381N     P=0.003N**   P=0.490N   |
|LOGISTIC REGRESSION    |  P=0.235N     P=0.050 *    P=0.450      P=0.473N   |  P=0.359N     P=0.365N     P=0.003N**   P=0.469N   |
|COCHRAN-ARMITAGE       |  P=0.232N                                          |  P=0.326N                                          |
|FISHER EXACT           |               P=0.055      P=0.453      P=0.500N   |               P=0.311N     P=0.002N**   P=0.418N   |
|=================================================================================================================================|
         DATE: 05/07/97                     EXPERIMENT: 05089 TEST: 01                                                 PAGE  12
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.00500%     0.0100%      0.0200%   |   VEHICLE      0.00500%     0.0100%      0.0200%   |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal                                                       |
|     Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/51 (10%)   7/50 (14%)   4/51 (8%)    4/50 (8%)  |  1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |  25.1%        23.8%        18.2%        21.1%      |   2.9%         3.6%         0.0%         0.0%      |
|TERMINAL (d)           |  2/14 (14%)   3/22 (14%)   1/14 (7%)    2/16 (13%) |  0/31 (0%)    1/28 (4%)    0/29 (0%)    0/24 (0%)  |
|FIRST INCIDENCE (DAYS) |   674          654          583          712       |   702          729 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.314N     P=0.618      P=0.482N     P=0.423N   |  P=0.265N     P=0.749      P=0.512N     P=0.531N   |
|INCIDENTAL TUMOR       |  P=0.245N     P=0.594      P=0.457N     P=0.363N   |  P=0.240N     P=0.749      P=0.536N     P=0.455N   |
|LOGISTIC REGRESSION    |  P=0.284N     P=0.532      P=0.478N     P=0.420N   |  P=0.246N     P=0.757      P=0.506N     P=0.507N   |
|COCHRAN-ARMITAGE       |  P=0.325N                                          |  P=0.236N                                          |
|FISHER EXACT           |               P=0.366      P=0.500N     P=0.513N   |               P=0.753N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/51 (0%)    4/50 (8%)    2/51 (4%)    5/50 (10%) |  2/50 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%        15.0%        11.2%        18.5%      |   5.5%         0.0%         3.4%         0.0%      |
|TERMINAL (d)           |  0/14 (0%)    2/22 (9%)    1/14 (7%)    1/16 (6%)  |  1/31 (3%)    0/28 (0%)    1/29 (3%)    0/24 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          667          690          656       |   666          ---          729 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.054      P=0.123      P=0.245      P=0.053    |  P=0.218N     P=0.265N     P=0.524N     P=0.279N   |
|INCIDENTAL TUMOR       |  P=0.073      P=0.111      P=0.247      P=0.058    |  P=0.203N     P=0.251N     P=0.537N     P=0.242N   |
|LOGISTIC REGRESSION    |  P=0.056      P=0.095      P=0.239      P=0.040 *  |  P=0.195N     P=0.241N     P=0.512N     P=0.242N   |
|COCHRAN-ARMITAGE       |  P=0.050                                           |  P=0.188N                                          |
|FISHER EXACT           |               P=0.056      P=0.248      P=0.027 *  |               P=0.247N     P=0.500N     P=0.247N   |
|=================================================================================================================================|
         DATE: 05/07/97                     EXPERIMENT: 05089 TEST: 01                                                 PAGE  13
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.00500%     0.0100%      0.0200%   |   VEHICLE      0.00500%     0.0100%      0.0200%   |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/51 (2%)    4/50 (8%)    2/51 (4%)    6/50 (12%) |  3/50 (6%)    0/50 (0%)    1/50 (2%)    2/50 (4%)  |
|ADJUSTED (b)           |   2.1%        15.0%        11.2%        20.5%      |   8.0%         0.0%         3.4%         5.7%      |
|TERMINAL (d)           |  0/14 (0%)    2/22 (9%)    1/14 (7%)    1/16 (6%)  |  1/31 (3%)    0/28 (0%)    1/29 (3%)    0/24 (0%)  |
|FIRST INCIDENCE (DAYS) |   465          667          690          619       |   666          ---          729 (T)      662       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.061      P=0.286      P=0.510      P=0.096    |  P=0.599N     P=0.141N     P=0.329N     P=0.551N   |
|INCIDENTAL TUMOR       |  P=0.069      P=0.146      P=0.454      P=0.068    |  P=0.526N     P=0.127N     P=0.351N     P=0.440N   |
|LOGISTIC REGRESSION    |  P=0.057      P=0.161      P=0.488      P=0.044 *  |  P=0.559N     P=0.120N     P=0.313N     P=0.495N   |
|COCHRAN-ARMITAGE       |  P=0.053                                           |  P=0.556N                                          |
|FISHER EXACT           |               P=0.175      P=0.500      P=0.053    |               P=0.121N     P=0.309N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/51 (2%)    0/50 (0%)    0/51 (0%)    1/50 (2%)  |  1/50 (2%)    0/50 (0%)    0/50 (0%)    2/50 (4%)  |
|ADJUSTED (b)           |   2.1%         0.0%         0.0%         2.4%      |   2.6%         0.0%         0.0%         5.7%      |
|TERMINAL (d)           |  0/14 (0%)    0/22 (0%)    0/14 (0%)    0/16 (0%)  |  0/31 (0%)    0/28 (0%)    0/29 (0%)    0/24 (0%)  |
|FIRST INCIDENCE (DAYS) |   465          ---          ---          619       |   668          ---          ---          662       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.617      P=0.488N     P=0.492N     P=0.722N   |  P=0.233      P=0.510N     P=0.505N     P=0.475    |
|INCIDENTAL TUMOR       |  P=0.542      P=0.892N     P=0.594N     P=0.663    |  P=0.303      P=0.500N     P=0.536N     P=0.580    |
|LOGISTIC REGRESSION    |  P=0.435      P=0.835N     P=0.677N     P=0.619    |  P=0.247      P=0.491N     P=0.491N     P=0.511    |
|COCHRAN-ARMITAGE       |  P=0.592                                           |  P=0.246                                           |
|FISHER EXACT           |               P=0.505N     P=0.500N     P=0.748    |               P=0.500N     P=0.500N     P=0.500    |
|=================================================================================================================================|
         DATE: 05/07/97                     EXPERIMENT: 05089 TEST: 01                                                 PAGE  14
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.00500%     0.0100%      0.0200%   |   VEHICLE      0.00500%     0.0100%      0.0200%   |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/51 (6%)    3/50 (6%)    2/51 (4%)    2/50 (4%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |  15.6%        10.6%         7.5%        11.2%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/14 (7%)    1/22 (5%)    0/14 (0%)    1/16 (6%)  |  0/31 (0%)    0/28 (0%)    0/29 (0%)    0/24 (0%)  |
|FIRST INCIDENCE (DAYS) |   687          662          583          718       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.365N     P=0.506N     P=0.485N     P=0.441N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.314N     P=0.533N     P=0.456N     P=0.398N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.349N     P=0.562N     P=0.483N     P=0.443N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.377N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.652      P=0.500N     P=0.509N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/51 (2%)    3/50 (6%)    1/51 (2%)    1/50 (2%)  |  0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   7.1%        11.5%         4.8%         4.8%      |   0.0%         3.6%         0.0%         0.0%      |
|TERMINAL (d)           |  1/14 (7%)    2/22 (9%)    0/14 (0%)    0/16 (0%)  |  0/31 (0%)    1/28 (4%)    0/29 (0%)    0/24 (0%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      654          698          712       |   ---          729 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.433N     P=0.462      P=0.749N     P=0.722N   |  P=0.603N     P=0.480        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.407N     P=0.450      P=0.753N     P=0.713N   |  P=0.603N     P=0.480        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.431N     P=0.399      P=0.764N     P=0.741N   |  P=0.603N     P=0.480        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.449N                                          |  P=0.567N                                          |
|FISHER EXACT           |               P=0.301      P=0.752N     P=0.748    |               P=0.500        (e)          (e)      |
|=================================================================================================================================|
         DATE: 05/07/97                     EXPERIMENT: 05089 TEST: 01                                                 PAGE  15
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.00500%     0.0100%      0.0200%   |   VEHICLE      0.00500%     0.0100%      0.0200%   |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/51 (10%)   6/50 (12%)   3/51 (6%)    3/50 (6%)  |  1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |  25.1%        21.2%        11.9%        15.4%      |   2.9%         3.6%         0.0%         0.0%      |
|TERMINAL (d)           |  2/14 (14%)   3/22 (14%)   0/14 (0%)    1/16 (6%)  |  0/31 (0%)    1/28 (4%)    0/29 (0%)    0/24 (0%)  |
|FIRST INCIDENCE (DAYS) |   674          654          583          712       |   702          729 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.205N     P=0.516N     P=0.343N     P=0.295N   |  P=0.265N     P=0.749      P=0.512N     P=0.531N   |
|INCIDENTAL TUMOR       |  P=0.152N     P=0.545N     P=0.314N     P=0.236N   |  P=0.240N     P=0.749      P=0.536N     P=0.455N   |
|LOGISTIC REGRESSION    |  P=0.183N     P=0.603N     P=0.335N     P=0.285N   |  P=0.246N     P=0.757      P=0.506N     P=0.507N   |
|COCHRAN-ARMITAGE       |  P=0.214N                                          |  P=0.236N                                          |
|FISHER EXACT           |               P=0.486      P=0.358N     P=0.369N   |               P=0.753N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/51 (8%)    6/50 (12%)   3/51 (6%)    3/50 (6%)  |  0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |  22.1%        21.2%        11.9%        15.4%      |   0.0%         3.6%         0.0%         0.0%      |
|TERMINAL (d)           |  2/14 (14%)   3/22 (14%)   0/14 (0%)    1/16 (6%)  |  0/31 (0%)    1/28 (4%)    0/29 (0%)    0/24 (0%)  |
|FIRST INCIDENCE (DAYS) |   687          654          583          712       |   ---          729 (T)      ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.290N     P=0.602      P=0.479N     P=0.423N   |  P=0.603N     P=0.480        (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.236N     P=0.577      P=0.458N     P=0.380N   |  P=0.603N     P=0.480        (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.271N     P=0.521      P=0.480N     P=0.432N   |  P=0.603N     P=0.480        (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.306N                                          |  P=0.567N                                          |
|FISHER EXACT           |               P=0.358      P=0.500N     P=0.511N   |               P=0.500        (e)          (e)      |
|=================================================================================================================================|
         DATE: 05/07/97                     EXPERIMENT: 05089 TEST: 01                                                 PAGE  16
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.00500%     0.0100%      0.0200%   |   VEHICLE      0.00500%     0.0100%      0.0200%   |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 33/51 (65%)  44/50 (88%)  38/51 (75%)  43/50 (86%) |                                                    |
|ADJUSTED (b)           |  96.7%       100.0%       100.0%        97.6%      |                                                    |
|TERMINAL (d)           | 13/14 (93%)  22/22 (100%) 14/14 (100%) 15/16 (94%) |                                                    |
|FIRST INCIDENCE (DAYS) |   446          579          533          524       |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.175      P=0.420N     P=0.302      P=0.295    |                                                    |
|INCIDENTAL TUMOR       |  P=0.082      P=0.146      P=0.334      P=0.058    |                                                    |
|LOGISTIC REGRESSION    |  P=0.098      P=0.125      P=0.296      P=0.059    |                                                    |
|COCHRAN-ARMITAGE       |  P=0.035 *                                         |                                                    |
|FISHER EXACT           |               P=0.005 **   P=0.195      P=0.012 *  |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  6/51 (12%)   2/50 (4%)    3/51 (6%)    3/50 (6%)  |  4/50 (8%)    4/50 (8%)    4/50 (8%)    3/50 (6%)  |
|ADJUSTED (b)           |  23.2%         5.2%         7.5%        10.6%      |  10.6%        14.3%        13.8%         8.6%      |
|TERMINAL (d)           |  1/14 (7%)    0/22 (0%)    0/14 (0%)    1/16 (6%)  |  2/31 (6%)    4/28 (14%)   4/29 (14%)   1/24 (4%)  |
|FIRST INCIDENCE (DAYS) |   541          627          586          530       |   620          729 (T)      729 (T)      589       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.238N     P=0.073N     P=0.237N     P=0.193N   |  P=0.521N     P=0.594      P=0.600      P=0.580N   |
|INCIDENTAL TUMOR       |  P=0.273N     P=0.190N     P=0.185N     P=0.302N   |  P=0.434N     P=0.632N     P=0.597N     P=0.380N   |
|LOGISTIC REGRESSION    |  P=0.320N     P=0.170N     P=0.260N     P=0.284N   |  P=0.424N     P=0.631      P=0.628      P=0.471N   |
|COCHRAN-ARMITAGE       |  P=0.262N                                          |  P=0.410N                                          |
|FISHER EXACT           |               P=0.141N     P=0.244N     P=0.254N   |               P=0.643N     P=0.643N     P=0.500N   |
|=================================================================================================================================|
         DATE: 05/07/97                     EXPERIMENT: 05089 TEST: 01                                                 PAGE  17
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.00500%     0.0100%      0.0200%   |   VEHICLE      0.00500%     0.0100%      0.0200%   |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/51 (2%)    2/50 (4%)    1/51 (2%)    0/50 (0%)  |  1/50 (2%)    2/50 (4%)    2/50 (4%)    0/50 (0%)  |
|ADJUSTED (b)           |   2.7%         8.7%         2.9%         0.0%      |   3.2%         7.1%         6.9%         0.0%      |
|TERMINAL (d)           |  0/14 (0%)    1/22 (5%)    0/14 (0%)    0/16 (0%)  |  1/31 (3%)    2/28 (7%)    2/29 (7%)    0/24 (0%)  |
|FIRST INCIDENCE (DAYS) |   598          718          618          ---       |   729 (T)      729 (T)      729 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.240N     P=0.620      P=0.760N     P=0.480N   |  P=0.361N     P=0.464      P=0.477      P=0.551N   |
|INCIDENTAL TUMOR       |  P=0.237N     P=0.540      P=0.698N     P=0.536N   |  P=0.361N     P=0.464      P=0.477      P=0.551N   |
|LOGISTIC REGRESSION    |  P=0.246N     P=0.541      P=0.746      P=0.565N   |  P=0.361N     P=0.464      P=0.477      P=0.551N   |
|COCHRAN-ARMITAGE       |  P=0.250N                                          |  P=0.296N                                          |
|FISHER EXACT           |               P=0.492      P=0.752N     P=0.505N   |               P=0.500      P=0.500      P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  7/51 (14%)   4/50 (8%)    4/51 (8%)    3/50 (6%)  |  5/50 (10%)   6/50 (12%)   6/50 (12%)   3/50 (6%)  |
|ADJUSTED (b)           |  25.2%        13.5%        10.2%        10.6%      |  13.7%        21.4%        20.7%         8.6%      |
|TERMINAL (d)           |  1/14 (7%)    1/22 (5%)    0/14 (0%)    1/16 (6%)  |  3/31 (10%)   6/28 (21%)   6/29 (21%)   1/24 (4%)  |
|FIRST INCIDENCE (DAYS) |   541          627          586          530       |   620          729 (T)      729 (T)      589       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.130N     P=0.136N     P=0.258N     P=0.124N   |  P=0.382N     P=0.436      P=0.448      P=0.450N   |
|INCIDENTAL TUMOR       |  P=0.143N     P=0.315N     P=0.175N     P=0.211N   |  P=0.308N     P=0.493      P=0.532      P=0.264N   |
|LOGISTIC REGRESSION    |  P=0.175N     P=0.293N     P=0.286N     P=0.200N   |  P=0.285N     P=0.482      P=0.475      P=0.336N   |
|COCHRAN-ARMITAGE       |  P=0.144N                                          |  P=0.262N                                          |
|FISHER EXACT           |               P=0.274N     P=0.263N     P=0.167N   |               P=0.500      P=0.500      P=0.357N   |
|=================================================================================================================================|
         DATE: 05/07/97                     EXPERIMENT: 05089 TEST: 01                                                 PAGE  18
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.00500%     0.0100%      0.0200%   |   VEHICLE      0.00500%     0.0100%      0.0200%   |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/51 (0%)    0/50 (0%)    0/51 (0%)    0/50 (0%)  |  3/50 (6%)    1/50 (2%)    2/50 (4%)    1/50 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   8.4%         3.6%         4.4%         2.7%      |
|TERMINAL (d)           |  0/14 (0%)    0/22 (0%)    0/14 (0%)    0/16 (0%)  |  1/31 (3%)    1/28 (4%)    0/29 (0%)    0/24 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   667          729 (T)      560          687       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.313N     P=0.333N     P=0.517N     P=0.342N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.229N     P=0.324N     P=0.438N     P=0.266N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.273N     P=0.313N     P=0.458N     P=0.312N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.279N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.309N     P=0.500N     P=0.309N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/51 (0%)    0/50 (0%)    0/51 (0%)    0/50 (0%)  |  3/50 (6%)    2/50 (4%)    2/50 (4%)    1/50 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   8.4%         7.1%         4.4%         2.7%      |
|TERMINAL (d)           |  0/14 (0%)    0/22 (0%)    0/14 (0%)    0/16 (0%)  |  1/31 (3%)    2/28 (7%)    0/29 (0%)    0/24 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   667          729 (T)      560          687       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.271N     P=0.535N     P=0.517N     P=0.342N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.198N     P=0.528N     P=0.438N     P=0.266N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.229N     P=0.512N     P=0.458N     P=0.312N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.232N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.500N     P=0.500N     P=0.309N   |
|=================================================================================================================================|
         DATE: 05/07/97                     EXPERIMENT: 05089 TEST: 01                                                 PAGE  19
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.00500%     0.0100%      0.0200%   |   VEHICLE      0.00500%     0.0100%      0.0200%   |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    | 10/50 (20%)   9/50 (18%)  12/50 (24%)  11/50 (22%) |
|ADJUSTED (b)           |                                                    |  24.7%        27.4%        34.4%        34.3%      |
|TERMINAL (d)           |                                                    |  4/31 (13%)   6/28 (21%)   7/29 (24%)   6/24 (25%) |
|FIRST INCIDENCE (DAYS) |                                                    |   508          626          605          591       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.240      P=0.558N     P=0.366      P=0.363    |
|INCIDENTAL TUMOR       |                                                    |  P=0.409      P=0.491N     P=0.422      P=0.578    |
|LOGISTIC REGRESSION    |                                                    |  P=0.371      P=0.494N     P=0.397      P=0.526    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.385                                           |
|FISHER EXACT           |                                                    |               P=0.500N     P=0.405      P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  0/50 (0%)    1/50 (2%)    3/50 (6%)    1/50 (2%)  |
|ADJUSTED (b)           |                                                    |   0.0%         3.6%         8.3%         4.2%      |
|TERMINAL (d)           |                                                    |  0/31 (0%)    1/28 (4%)    1/29 (3%)    1/24 (4%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   ---          729 (T)      620          729 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.301      P=0.480      P=0.113      P=0.449    |
|INCIDENTAL TUMOR       |                                                    |  P=0.351      P=0.480      P=0.139      P=0.449    |
|LOGISTIC REGRESSION    |                                                    |  P=0.346      P=0.480      P=0.124      P=0.449    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.351                                           |
|FISHER EXACT           |                                                    |               P=0.500      P=0.121      P=0.500    |
|=================================================================================================================================|
         DATE: 05/07/97                     EXPERIMENT: 05089 TEST: 01                                                 PAGE  20
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.00500%     0.0100%      0.0200%   |   VEHICLE      0.00500%     0.0100%      0.0200%   |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    | 10/50 (20%)  10/50 (20%)  15/50 (30%)  11/50 (22%) |
|ADJUSTED (b)           |                                                    |  24.7%        30.7%        40.5%        34.3%      |
|TERMINAL (d)           |                                                    |  4/31 (13%)   7/28 (25%)   8/29 (28%)   6/24 (25%) |
|FIRST INCIDENCE (DAYS) |                                                    |   508          626          605          591       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.239      P=0.532      P=0.166      P=0.363    |
|INCIDENTAL TUMOR       |                                                    |  P=0.417      P=0.595N     P=0.197      P=0.578    |
|LOGISTIC REGRESSION    |                                                    |  P=0.374      P=0.597N     P=0.175      P=0.526    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.388                                           |
|FISHER EXACT           |                                                    |               P=0.598N     P=0.178      P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 25/51 (49%)  26/50 (52%)  29/51 (57%)  30/50 (60%) |  8/50 (16%)  11/50 (22%)  15/50 (30%)  16/50 (32%) |
|ADJUSTED (b)           |  73.1%        65.5%        89.1%        80.8%      |  20.8%        29.0%        39.3%        41.4%      |
|TERMINAL (d)           |  6/14 (43%)  10/22 (45%)  11/14 (79%)  10/16 (63%) |  4/31 (13%)   4/28 (14%)   8/29 (28%)   4/24 (17%) |
|FIRST INCIDENCE (DAYS) |   315          581          429          495       |   472          540          465          592       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.244      P=0.186N     P=0.337      P=0.464    |  P=0.021 *    P=0.280      P=0.077      P=0.036 *  |
|INCIDENTAL TUMOR       |  P=0.132      P=0.540      P=0.233      P=0.188    |  P=0.062      P=0.269      P=0.075      P=0.096    |
|LOGISTIC REGRESSION    |  P=0.164      P=0.503      P=0.223      P=0.213    |  P=0.035 *    P=0.322      P=0.087      P=0.058    |
|COCHRAN-ARMITAGE       |  P=0.139                                           |  P=0.034 *                                         |
|FISHER EXACT           |               P=0.460      P=0.276      P=0.182    |               P=0.306      P=0.077      P=0.050    |
|=================================================================================================================================|
         DATE: 05/07/97                     EXPERIMENT: 05089 TEST: 01                                                 PAGE  21
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.00500%     0.0100%      0.0200%   |   VEHICLE      0.00500%     0.0100%      0.0200%   |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Benign, Malignant, NOS                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/51 (2%)    0/50 (0%)    2/51 (4%)    1/50 (2%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   5.3%         0.0%        11.8%         2.2%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/14 (0%)    0/22 (0%)    1/14 (7%)    0/16 (0%)  |  0/31 (0%)    0/28 (0%)    0/29 (0%)    0/24 (0%)  |
|FIRST INCIDENCE (DAYS) |   710          ---          701          587       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.507      P=0.453N     P=0.493      P=0.730N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.530      P=0.464N     P=0.515      P=0.750N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.511      P=0.449N     P=0.502      P=0.758    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.496                                           |    (e)                                             |
|FISHER EXACT           |               P=0.505N     P=0.500      P=0.748    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 47/51 (92%)  50/50 (100%) 50/51 (98%)  49/50 (98%) | 45/50 (90%)  42/50 (84%)  37/50 (74%)  44/50 (88%) |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%      |  95.7%        91.3%        84.0%        93.5%      |
|TERMINAL (d)           | 14/14 (100%) 22/22 (100%) 14/14 (100%) 16/16 (100%)| 29/31 (94%)  24/28 (86%)  22/29 (76%)  21/24 (88%) |
|FIRST INCIDENCE (DAYS) |   446          473          447          524       |   508          540          560          465       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.504      P=0.066N     P=0.455      P=0.334N   |  P=0.184      P=0.551      P=0.220N     P=0.203    |
|INCIDENTAL TUMOR       |  P=0.637N     P=0.748      P=0.674      P=0.751    |  P=0.418N     P=0.436N     P=0.040N*    P=0.532N   |
|LOGISTIC REGRESSION    |  P=0.544N     P=0.543      P=0.523      P=0.667N   |  P=0.432N     P=0.400N     P=0.054N     P=0.540N   |
|COCHRAN-ARMITAGE       |  P=0.166                                           |  P=0.448N                                          |
|FISHER EXACT           |               P=0.061      P=0.181      P=0.187    |               P=0.277N     P=0.033N*    P=0.500N   |
|=================================================================================================================================|
         DATE: 05/07/97                     EXPERIMENT: 05089 TEST: 01                                                 PAGE  22
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   VEHICLE      0.00500%     0.0100%      0.0200%   |   VEHICLE      0.00500%     0.0100%      0.0200%   |
|                       |   CONTROL                                          |   CONTROL                                          |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 31/51 (61%)  28/50 (56%)  37/51 (73%)  36/50 (72%) | 16/50 (32%)  15/50 (30%)  22/50 (44%)  19/50 (38%) |
|ADJUSTED (b)           |  79.7%        71.3%        91.1%        86.3%      |  40.6%        39.2%        52.8%        48.9%      |
|TERMINAL (d)           |  7/14 (50%)  12/22 (55%)  11/14 (79%)  11/16 (69%) |  9/31 (29%)   7/28 (25%)  11/29 (38%)   6/24 (25%) |
|FIRST INCIDENCE (DAYS) |   315          581          429          495       |   472          452          465          592       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.204      P=0.057N     P=0.278      P=0.507    |  P=0.117      P=0.571N     P=0.146      P=0.201    |
|INCIDENTAL TUMOR       |  P=0.057      P=0.365N     P=0.144      P=0.149    |  P=0.297      P=0.585      P=0.155      P=0.428    |
|LOGISTIC REGRESSION    |  P=0.060      P=0.392N     P=0.146      P=0.148    |  P=0.216      P=0.491N     P=0.162      P=0.339    |
|COCHRAN-ARMITAGE       |  P=0.067                                           |  P=0.213                                           |
|FISHER EXACT           |               P=0.388N     P=0.147      P=0.163    |               P=0.500N     P=0.151      P=0.338    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 50/51 (98%)  50/50 (100%) 51/51 (100%) 50/50 (100%)| 48/50 (96%)  45/50 (90%)  44/50 (88%)  47/50 (94%) |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%      |  96.0%        93.7%        93.6%        95.9%      |
|TERMINAL (d)           | 14/14 (100%) 22/22 (100%) 14/14 (100%) 16/16 (100%)| 29/31 (94%)  25/28 (89%)  26/29 (90%)  22/24 (92%) |
|FIRST INCIDENCE (DAYS) |   315          473          429          495       |   472          299          465          465       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.477N     P=0.032N*    P=0.541N     P=0.253N   |  P=0.154      P=0.540      P=0.468N     P=0.198    |
|INCIDENTAL TUMOR       |  P=0.375      P=0.892      P=0.594      P=0.638    |  P=0.418N     P=0.328N     P=0.193N     P=0.433N   |
|LOGISTIC REGRESSION    |  P=0.432      P=0.736      P=0.603      P=0.694    |  P=0.525N     P=0.249N     P=0.209N     P=0.504N   |
|COCHRAN-ARMITAGE       |  P=0.307                                           |  P=0.500N                                          |
|FISHER EXACT           |               P=0.505      P=0.500      P=0.505    |               P=0.218N     P=0.134N     P=0.500N   |
|=================================================================================================================================|
         DATE: 05/07/97                     EXPERIMENT: 05089 TEST: 01                                                 PAGE  23
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER 344) -- CHLORAMINE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
                                                                           
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).

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