National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2252

TR 393 Mouse Pathology Tables

NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97
Route: DOSED WATER                                                                                                Time: 18:55:53




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  7681-49-4

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 4| 1| 7| 6| 7| 1| 4| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 5| 3| 3| 2| 5| 5| 3| 3| 3| 3| 3| 5| 6| 2| 7| 3| 6| 5| 3| 3| 3| 2| 3| 5|             
                                           | 0| 9| 0| 0| 2| 7| 9| 1| 1| 1| 1| 1| 8| 6| 9| 0| 1| 5| 9| 1| 1| 2| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
     0 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Lymphoid Tissue, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     | X                                                                        |             
      Eosinophilic Focus                   |       X  X                    X     X     X              X  X        X   |             
      Hematopoietic Cell Proliferation     | 2                                                        2               |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Bile Duct, Cyst                      |                               X                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                   +  +           +  +  +      |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Necrotizing            |          4                                   4  4           4  4         |             
      Mineralization                       |          2                                                  2  2         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           | 2                                                                        |             
      Diverticulum                         |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Hyperplasia                          |          2                                                               |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Dentine, Incisor, Dysplasia          | 1     1  1  1        2        1  1  1           1           1  1     1   |             
      Incisor, Ameloblast, Atrophy         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 4| 1| 7| 6| 7| 1| 4| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 5| 3| 3| 2| 5| 5| 3| 3| 3| 3| 3| 5| 6| 2| 7| 3| 6| 5| 3| 3| 3| 2| 3| 5|             
                                           | 0| 9| 0| 0| 2| 7| 9| 1| 1| 1| 1| 1| 8| 6| 9| 0| 1| 5| 9| 1| 1| 2| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
     0 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Degeneration, Fatty                  |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                                                       2                  |             
      Hypertrophy                          | 2                          1                                             |             
      Capsule, Spindle Cell, Hyperplasia   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                             2            |             
      Hypertrophy                          |                                                          2               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |       X                       X           X                          X   |             
      Pars Distalis, Hyperplasia           |                               2           2  2                           |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Ultimobranchial Cyst                 |                                                                          |             
      Follicular Cell, Hyperplasia         |       1                    2  2  2                          1  2         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
      Pigmentation, Melanin                |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4     4  2  4        2  2  2  2  2        3  4  3        3  2  2  2  4   |             
      Cyst                                 | X     X  X                                   X           X               |             
      Mineralization                       |                                              3                           |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Dilatation                           |       4                 4        3                          4            |             
      Hyperplasia, Cystic, Glandular       |    3  2  2  2     3  3  2     2  3  4     2  1  3     3  2  3  2  2  2  2|             
      Inflammation, Necrotizing            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 4| 1| 7| 6| 7| 1| 4| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 5| 3| 3| 2| 5| 5| 3| 3| 3| 3| 3| 5| 6| 2| 7| 3| 6| 5| 3| 3| 3| 2| 3| 5|             
                                           | 0| 9| 0| 0| 2| 7| 9| 1| 1| 1| 1| 1| 8| 6| 9| 0| 1| 5| 9| 1| 1| 2| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
     0 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hyperplasia, Mast Cell      |                                                                          |             
      Femoral, Myelofibrosis               |                         1     1           1     2                 1  1   |             
      Humerus, Myelofibrosis               |             2        1  1     1                 1                       1|             
      Mandible, Myelofibrosis              |                                                                          |             
      Maxilla, Hyperplasia, Mast Cell      |                                                                          |             
      Maxilla, Myelofibrosis               |    1                    1     1  2              2                 1      |             
      Thoracic, Vertebra, Myelofibrosis    |    1  2        1     1  1     3  2  2     3     2     1  1     1  2  2  1|             
      Tibia, Myelofibrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                            3                 2           3           2   |             
      Hyperplasia, Lymphoid                |          2                       2              2                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
      Hair Follicle, Cyst                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +|             
      Humerus, Osteosclerosis              |                                                                2         |             
      Intervertebral Disc, Degeneration    |       3                          2                          3  2         |             
      Periosteum, Tibia, Proliferation,    |                                                                          |             
           Focal                           |                                                                          |             
      Rib, Cartilage, Necrosis             |                                                                          |             
      Thoracic, Vertebra, Osteosclerosis   |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                        +           +                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 4| 1| 7| 6| 7| 1| 4| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 5| 3| 3| 2| 5| 5| 3| 3| 3| 3| 3| 5| 6| 2| 7| 3| 6| 5| 3| 3| 3| 2| 3| 5|             
                                           | 0| 9| 0| 0| 2| 7| 9| 1| 1| 1| 1| 1| 8| 6| 9| 0| 1| 5| 9| 1| 1| 2| 9| 2| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
     0 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Compression                          |                X                                                         |             
      Hydrocephalus                        |                3                                                         |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                      2        1                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                          2               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                          +               |             
      Inflammation, Chronic Active         |                                                          2               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | I  M  M  M  +  M  +  M  M  M  +  +  +  +  M  +  M  +  +  +  +  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Hypertrophy                          |                                                                          |             
      Mineralization                       |       1  1     1     1  1  1  1  1        1  1  1        1  1  1     1   |             
      Nephropathy, Chronic                 | 1        1           1  1     1  1        1  1  1        1  1  1     1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 7| 6| 6| 1| 7| 7| 1| 5| 6| 7| 5| 7| 7| 7| 7| 7| 6| 1| 7| 1| 7| 6| 5|             
                             DAY ON TEST   | 6| 2| 2| 3| 4| 6| 3| 3| 6| 1| 3| 3| 9| 3| 3| 3| 2| 3| 7| 6| 3| 6| 2| 5| 2|             
                                           | 5| 2| 9| 7| 4| 6| 2| 2| 5| 8| 2| 2| 2| 2| 2| 2| 9| 3| 6| 6| 3| 6| 9| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
     0 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                              4                           |             
      Lymphoid Tissue, Hyperplasia         |                                              4                           |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                                         X|             
      Eosinophilic Focus                   |             X     X              X     X  X                 X            |             
      Hematopoietic Cell Proliferation     |                                        2  2                 2            |             
      Inflammation, Chronic Active         |             2                                                            |             
      Necrosis, Coagulative                |          3                 3                                             |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Bile Duct, Cyst                      |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +  +     +                    +              +  +              +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Necrotizing            |    4  4     4                    4              4  4              4     4|             
      Mineralization                       |                                  2              3                 2      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                       2                  |             
      Acinus, Atrophy                      |                                  1                    4                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                        3                    2            |             
      Diverticulum                         |                                                                         2|             
      Inflammation, Chronic Active         |                                        3                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                               2                                          |             
      Hyperplasia                          |                                        2                                 |             
                                            __________________________________________________________________________|             
   Tooth                                   |    +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +|             
      Dentine, Incisor, Dysplasia          |                   1        1  1              1  3  1        1            |             
      Incisor, Ameloblast, Atrophy         |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 7| 6| 6| 1| 7| 7| 1| 5| 6| 7| 5| 7| 7| 7| 7| 7| 6| 1| 7| 1| 7| 6| 5|             
                             DAY ON TEST   | 6| 2| 2| 3| 4| 6| 3| 3| 6| 1| 3| 3| 9| 3| 3| 3| 2| 3| 7| 6| 3| 6| 2| 5| 2|             
                                           | 5| 2| 9| 7| 4| 6| 2| 2| 5| 8| 2| 2| 2| 2| 2| 2| 9| 3| 6| 6| 3| 6| 9| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
     0 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Degeneration, Fatty                  |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |                                                                          |             
      Capsule, Spindle Cell, Hyperplasia   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |       X                                                                  |             
      Pars Distalis, Hyperplasia           |                      2                       3                           |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Ultimobranchial Cyst                 |                                                                          |             
      Follicular Cell, Hyperplasia         |    2        4        2                             2              2  2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                              +                           |             
      Pigmentation, Melanin                |                                              2                           |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       3  3        2  2     3     3     2  2  3  3  2  4     2     3      |             
      Cyst                                 |       X  X                                   X  X           X     X  X   |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Dilatation                           |                      4                    4     3                        |             
      Hyperplasia, Cystic, Glandular       |       2  2  2     3  3     3  2  4  2  2  2  2  2  4        3     2  2  3|             
      Inflammation, Necrotizing            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 7| 6| 6| 1| 7| 7| 1| 5| 6| 7| 5| 7| 7| 7| 7| 7| 6| 1| 7| 1| 7| 6| 5|             
                             DAY ON TEST   | 6| 2| 2| 3| 4| 6| 3| 3| 6| 1| 3| 3| 9| 3| 3| 3| 2| 3| 7| 6| 3| 6| 2| 5| 2|             
                                           | 5| 2| 9| 7| 4| 6| 2| 2| 5| 8| 2| 2| 2| 2| 2| 2| 9| 3| 6| 6| 3| 6| 9| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
     0 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |             +                                                            |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hyperplasia, Mast Cell      |                                                                          |             
      Femoral, Myelofibrosis               |    1                          1        1     2              1     1      |             
      Humerus, Myelofibrosis               |       2                          1     1     1                           |             
      Mandible, Myelofibrosis              |                                                                          |             
      Maxilla, Hyperplasia, Mast Cell      |                                                                          |             
      Maxilla, Myelofibrosis               |          1  1                                               1            |             
      Thoracic, Vertebra, Myelofibrosis    |    1  2           2  1     1           2     2  2           2     2      |             
      Tibia, Myelofibrosis                 |       2           3                       3                       3      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             |                                              3                           |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    3     3                 3        3                                    |             
      Hyperplasia, Lymphoid                |                                  2                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                       2           2      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |       2                                                                  |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic Active         |       2  4                                                               |             
      Mineralization                       |                                                                          |             
      Hair Follicle, Cyst                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +     +     +  +  +|             
      Humerus, Osteosclerosis              |                   2                                                      |             
      Intervertebral Disc, Degeneration    |       3     2     2                       3                              |             
      Periosteum, Tibia, Proliferation,    |                                                                          |             
           Focal                           |                                                                          |             
      Rib, Cartilage, Necrosis             |                                                       3                  |             
      Thoracic, Vertebra, Osteosclerosis   |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +              +        +                                +     +         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 7| 6| 6| 1| 7| 7| 1| 5| 6| 7| 5| 7| 7| 7| 7| 7| 6| 1| 7| 1| 7| 6| 5|             
                             DAY ON TEST   | 6| 2| 2| 3| 4| 6| 3| 3| 6| 1| 3| 3| 9| 3| 3| 3| 2| 3| 7| 6| 3| 6| 2| 5| 2|             
                                           | 5| 2| 9| 7| 4| 6| 2| 2| 5| 8| 2| 2| 2| 2| 2| 2| 9| 3| 6| 6| 3| 6| 9| 2| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
     0 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Compression                          |             X                                         X                  |             
      Hydrocephalus                        |             3                                         3                  |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |          +                                                               |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |             1                                2                           |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  M  +  M  M  M  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Hypertrophy                          |                                                                          |             
      Mineralization                       |    1  1  1           1        1  1        1     1  1  1     1            |             
      Nephropathy, Chronic                 |       1           1              1     1  1  1     1  1     1     1      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 8| 0| 3| 2| 5| 3| 2| 2| 1| 3| 2| 3| 5| 3| 3| 6| 3| 9| 2| 1| 3| 0| 1| 3|             
                                           | 3| 9| 2| 3| 9| 8| 3| 2| 9| 0| 3| 9| 3| 8| 3| 6| 2| 6| 1| 9| 5| 6| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
     0 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                           2                              |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Lymphoid Tissue, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   | X        X                       X                       X  X        X   |             
      Hematopoietic Cell Proliferation     |                                                             2            |             
      Inflammation, Chronic Active         |                      3                                                   |             
      Necrosis, Coagulative                |                      4                          3  2                     |             
      Vacuolization Cytoplasmic            |    3        2  1                                                         |             
      Bile Duct, Cyst                      |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                      +  +           +  +  +   |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Necrotizing            |          4                                         4              4  4   |             
      Mineralization                       |          2                                                           4   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      |                                                                2         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |          3                                                               |             
      Diverticulum                         |                                                                          |             
      Inflammation, Chronic Active         |          3                                            4                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dentine, Incisor, Dysplasia          |       1  1                 1                 1                 1  1     1|             
      Incisor, Ameloblast, Atrophy         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 8| 0| 3| 2| 5| 3| 2| 2| 1| 3| 2| 3| 5| 3| 3| 6| 3| 9| 2| 1| 3| 0| 1| 3|             
                                           | 3| 9| 2| 3| 9| 8| 3| 2| 9| 0| 3| 9| 3| 8| 3| 6| 2| 6| 1| 9| 5| 6| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
     0 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              |                               1                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |          X                       X                             X         |             
      Degeneration, Fatty                  |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                                                          2               |             
      Hypertrophy                          |                                              1           2               |             
      Capsule, Spindle Cell, Hyperplasia   |                            3                                             |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  M  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |          2     2  2     3                          2     2               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |          2                                                               |             
      Ultimobranchial Cyst                 |                                                                          |             
      Follicular Cell, Hyperplasia         |          2              2        1  1     2  2           2        2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
      Pigmentation, Melanin                |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3     4  3  2     3  3     4  3  3  3     2  2  3        2  4     3  3  2|             
      Cyst                                 |       X                    X     X                 X     X     X  X      |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Dilatation                           |                                  3  4                                    |             
      Hyperplasia, Cystic, Glandular       | 2     2  4  2  3  3  3  3  2  2  4  2  2  2  3     3  2  3  2  4  3  3  4|             
      Inflammation, Necrotizing            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 8| 0| 3| 2| 5| 3| 2| 2| 1| 3| 2| 3| 5| 3| 3| 6| 3| 9| 2| 1| 3| 0| 1| 3|             
                                           | 3| 9| 2| 3| 9| 8| 3| 2| 9| 0| 3| 9| 3| 8| 3| 6| 2| 6| 1| 9| 5| 6| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
     0 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                   +      |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hyperplasia, Mast Cell      |                               2                                          |             
      Femoral, Myelofibrosis               | 1        2  1  1  1  2     1     1        1        1     1           1   |             
      Humerus, Myelofibrosis               | 1           3     1     1     2              1                       2   |             
      Mandible, Myelofibrosis              |                                                                          |             
      Maxilla, Hyperplasia, Mast Cell      |                               1                                          |             
      Maxilla, Myelofibrosis               |             2     2     1           1                 1  1               |             
      Thoracic, Vertebra, Myelofibrosis    | 2        2  4     2  2  2  1  2  1  2  1  3  3     1  2  1  1  1     2   |             
      Tibia, Myelofibrosis                 | 1                    1                    1  1                 1     1   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Sinus, Ectasia                       |                   4                                                      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |             2        4     3        2           3           4            |             
      Hyperplasia, Lymphoid                |    2              2     2                          2                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                  2                          2            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
      Hair Follicle, Cyst                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Humerus, Osteosclerosis              |                                                                          |             
      Intervertebral Disc, Degeneration    | 3        1                    1  1                 3     2               |             
      Periosteum, Tibia, Proliferation,    |                                                                          |             
           Focal                           |                                                                          |             
      Rib, Cartilage, Necrosis             |                                                                          |             
      Thoracic, Vertebra, Osteosclerosis   |       1                                                                  |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 7| 7| 4| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 8| 0| 3| 2| 5| 3| 2| 2| 1| 3| 2| 3| 5| 3| 3| 6| 3| 9| 2| 1| 3| 0| 1| 3|             
                                           | 3| 9| 2| 3| 9| 8| 3| 2| 9| 0| 3| 9| 3| 8| 3| 6| 2| 6| 1| 9| 5| 6| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
     0 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Compression                          |                                                                          |             
      Hydrocephalus                        |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |          3                                                               |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  M  +  +  M  +  M  M  +  M  +  +  +  +  +  M  +  M  M  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                 3                        |             
      Hypertrophy                          |                                                 4                        |             
      Mineralization                       | 1     1  1  1     1  1  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1|             
      Nephropathy, Chronic                 |          1  2     1     1     1     1  1        2  1     1     1  2  1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 5| 4| 1| 7| 7| 7| 6| 1| 7| 7| 3| 7| 7| 7| 4| 7| 7| 1| 4| 7| 6| 7|            |
                             DAY ON TEST   | 2| 3| 3| 9| 5| 6| 3| 3| 2| 6| 6| 3| 3| 5| 3| 3| 3| 5| 3| 3| 6| 5| 1| 2| 3|            |
                                           | 0| 6| 6| 2| 8| 6| 6| 6| 9| 2| 6| 7| 7| 8| 7| 7| 7| 8| 7| 7| 6| 8| 3| 0| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|      A     |
     0 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
      Mineralization                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  98        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Lymphoid Tissue, Hyperplasia         |                                  4                       3               |      3  3.7|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Basophilic Focus                     |                                     X                             X      |      2     |
      Clear Cell Focus                     |                                  X                                       |      3     |
      Eosinophilic Focus                   |       X           X                                      X               |     23     |
      Hematopoietic Cell Proliferation     |                                                                          |      6  2.0|
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
      Necrosis, Coagulative                | 2                                                                 2      |      7  2.7|
      Vacuolization Cytoplasmic            | 2                                                     2        2         |      6  2.0|
      Bile Duct, Cyst                      |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +     +                                +     +        +  +           +   |  28        |
      Hemorrhage                           |                                                       2                  |      1  2.0|
      Inflammation, Necrotizing            | 4     4                                4     4        4  4           4   |     24  4.0|
      Mineralization                       |       2                                      2           2               |     11  2.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Acinus, Atrophy                      |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Acanthosis                           |                                           3                              |      5  2.6|
      Diverticulum                         |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      3  3.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Erosion                              |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +|  90        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 5| 4| 1| 7| 7| 7| 6| 1| 7| 7| 3| 7| 7| 7| 4| 7| 7| 1| 4| 7| 6| 7|            |
                             DAY ON TEST   | 2| 3| 3| 9| 5| 6| 3| 3| 2| 6| 6| 3| 3| 5| 3| 3| 3| 5| 3| 3| 6| 5| 1| 2| 3|            |
                                           | 0| 6| 6| 2| 8| 6| 6| 6| 9| 2| 6| 7| 7| 8| 7| 7| 7| 8| 7| 7| 6| 8| 3| 0| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|      A     |
     0 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Dentine, Incisor, Dysplasia          |    1              1  1  1  1                    1     1                 1|     34  1.1|
      Incisor, Ameloblast, Atrophy         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
      Cardiomyopathy, Chronic              |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                         2|      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      3     |
      Degeneration, Fatty                  |                                                 1     2                  |      2  1.5|
      Hematopoietic Cell Proliferation     |                                                                   2      |      1  2.0|
      Hyperplasia                          |                                                       2                  |      3  2.0|
      Hypertrophy                          |                                                 2     2                  |      6  1.7|
      Capsule, Spindle Cell, Hyperplasia   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  96        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Hypertrophy                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +|  92        |
      Cyst                                 |                                     X                                    |      1     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Pars Distalis, Cyst                  |                                                                          |      5     |
      Pars Distalis, Hyperplasia           |       2           3              2           2                       2   |     16  2.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Ultimobranchial Cyst                 |                                                                      X   |      1     |
      Follicular Cell, Hyperplasia         |    1              2  3  1        2  2        2        2  2              2|     30  1.9|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                          +               |   2        |
      Pigmentation, Melanin                |                                                                          |      1  2.0|
      Duct, Dilatation                     |                                                          2               |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 5| 4| 1| 7| 7| 7| 6| 1| 7| 7| 3| 7| 7| 7| 4| 7| 7| 1| 4| 7| 6| 7|            |
                             DAY ON TEST   | 2| 3| 3| 9| 5| 6| 3| 3| 2| 6| 6| 3| 3| 5| 3| 3| 3| 5| 3| 3| 6| 5| 1| 2| 3|            |
                                           | 0| 6| 6| 2| 8| 6| 6| 6| 9| 2| 6| 7| 7| 8| 7| 7| 7| 8| 7| 7| 6| 8| 3| 0| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|      A     |
     0 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  98        |
      Atrophy                              |       2           2  2  2  3     2  2     1  2  2     2  2        3     2|     63  2.6|
      Cyst                                 |    X  X           X                                   X              X   |     24     |
      Mineralization                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Angiectasis                          |       2                                                                  |      1  2.0|
      Dilatation                           |       4                             4                             4     3|     13  3.7|
      Hyperplasia, Cystic, Glandular       | 2  4     2  2     3  2  3  1     2  4  1  4  4  4  3  3  2     3     4  3|     81  2.6|
      Inflammation, Necrotizing            |                                                                   4      |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Femoral, Hyperplasia, Mast Cell      |                                                                          |      1  2.0|
      Femoral, Myelofibrosis               |       1  1        1  2     1              1  1  1  1  1                  |     34  1.1|
      Humerus, Myelofibrosis               | 1     1  1        1     1  1              2  1              1     2  1   |     28  1.3|
      Mandible, Myelofibrosis              | 3                                                                        |      1  3.0|
      Maxilla, Hyperplasia, Mast Cell      |                                                                          |      1  1.0|
      Maxilla, Myelofibrosis               |       2           1  4                          1                        |     19  1.4|
      Thoracic, Vertebra, Myelofibrosis    | 1  3  2  3        1  1  2  2     1  2     2  2  2     2        2        1|     61  1.8|
      Tibia, Myelofibrosis                 |             1           1                 4     1                        |     14  1.7|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  96        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
      Sinus, Ectasia                       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
      Hematopoietic Cell Proliferation     | 4                 3              3                    2  2        4      |     20  2.9|
      Hyperplasia, Lymphoid                |                            2                             2               |     10  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  96        |
      Cyst                                 | X                                                  X                     |      4     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  98        |
      Hyperplasia, Cystic                  |                   1                                      1        1     1|      8  1.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Acanthosis                           |                                                                          |      1  2.0|
      Hyperkeratosis                       |       2                                                                  |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 5| 4| 1| 7| 7| 7| 6| 1| 7| 7| 3| 7| 7| 7| 4| 7| 7| 1| 4| 7| 6| 7|            |
                             DAY ON TEST   | 2| 3| 3| 9| 5| 6| 3| 3| 2| 6| 6| 3| 3| 5| 3| 3| 3| 5| 3| 3| 6| 5| 1| 2| 3|            |
                                           | 0| 6| 6| 2| 8| 6| 6| 6| 9| 2| 6| 7| 7| 8| 7| 7| 7| 8| 7| 7| 6| 8| 3| 0| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|      A     |
     0 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |       2                                                                  |      1  2.0|
      Hair Follicle, Cyst                  |                                              X                           |      1     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +|  90        |
      Humerus, Osteosclerosis              |                                                                          |      2  2.0|
      Intervertebral Disc, Degeneration    |                                                                          |     14  2.2|
      Periosteum, Tibia, Proliferation,    |                                                                          |            |
           Focal                           |       3                                                                  |      1  3.0|
      Rib, Cartilage, Necrosis             |                                                                          |      1  3.0|
      Thoracic, Vertebra, Osteosclerosis   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +              +              +                             +            |  12        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Compression                          |                                                                          |      3     |
      Hydrocephalus                        |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Inflammation, Chronic Active         |                                                                          |      3  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                        I                                 |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  I  +  +  +  M  +  M  +  M  M  +  +  M  +  +  +  +  +  M|  66        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Hydronephrosis                       |                                                                          |      1  3.0|
      Hypertrophy                          |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 5| 4| 1| 7| 7| 7| 6| 1| 7| 7| 3| 7| 7| 7| 4| 7| 7| 1| 4| 7| 6| 7|            |
                             DAY ON TEST   | 2| 3| 3| 9| 5| 6| 3| 3| 2| 6| 6| 3| 3| 5| 3| 3| 3| 5| 3| 3| 6| 5| 1| 2| 3|            |
                                           | 0| 6| 6| 2| 8| 6| 6| 6| 9| 2| 6| 7| 7| 8| 7| 7| 7| 8| 7| 7| 6| 8| 3| 0| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|      A     |
     0 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |    1  1           1  1  1  1     1  1     1  1  1     1  1        1     1|     63  1.0|
      Nephropathy, Chronic                 |    1  1           1  1  1  1        1     1  1  1  1     1        1  1  1|     52  1.1|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Inflammation, Necrotizing            |                                                                   4      |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 6| 3| 7| 6| 6| 6| 7| 5| 4| 7| 7| 3| 2| 3| 7| 5| 3| 5| 7| 1| 6| 6| 2|             
                             DAY ON TEST   | 7| 5| 5| 4| 3| 9| 0| 9| 3| 0| 3| 0| 1| 1| 5| 7| 3| 5| 9| 6| 3| 9| 6| 7| 4|             
                                           | 9| 6| 2| 9| 0| 8| 3| 1| 0| 0| 3| 6| 3| 3| 9| 9| 0| 2| 5| 6| 1| 8| 6| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
    SPECIAL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +     +  +  +     +  +  +  +  +  +  M     +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
      Lymphoid Tissue, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
      Basophilic Focus                     | X  X              X                                X                     |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |                                     X              X                     |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Leukocytosis                         |                                                                          |             
      Necrosis, Coagulative                |                                     2                                    |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Vacuolization Cytoplasmic            |    2                                                                     |             
      Bile Duct, Cyst                      |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +     +                                   +   |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Necrotizing            |                            2                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +        +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
      Erosion                              |                                                                      2   |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
      Dentine, Incisor, Dysplasia          |                                                                          |             
      Incisor, Lower, Dysplasia            |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +        +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 6| 3| 7| 6| 6| 6| 7| 5| 4| 7| 7| 3| 2| 3| 7| 5| 3| 5| 7| 1| 6| 6| 2|             
                             DAY ON TEST   | 7| 5| 5| 4| 3| 9| 0| 9| 3| 0| 3| 0| 1| 1| 5| 7| 3| 5| 9| 6| 3| 9| 6| 7| 4|             
                                           | 9| 6| 2| 9| 0| 8| 3| 1| 0| 0| 3| 6| 3| 3| 9| 9| 0| 2| 5| 6| 1| 8| 6| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
    SPECIAL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +        +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +     M  +  +     +  M  +  +  +  +  +     +  +  +     +  +  +  +|             
      Hyperplasia                          |       2                                                                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  M  +|             
      Pars Distalis, Cyst                  |                X                                                         |             
      Pars Distalis, Hyperplasia           |                      2                                                   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
      Inflammation, Chronic Active         |                                                                   2      |             
      Follicular Cell, Hyperplasia         |                3                 2  2              1                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
      Atrophy                              |       2        4  3  3           4  3                             4  4   |             
      Cyst                                 |    X              X  X     X     X                             X  X      |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis, Coagulative                |                4                                                         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
      Dilatation                           |       4  4        4           3                          4        4      |             
      Hyperplasia, Cystic, Glandular       |    2  2  3     3  4  2     2     2  3  2     2     4  3  3     2     3  1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                      +                                                   |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
      Femoral, Myelofibrosis               |    1           1                    1                                    |             
      Humerus, Myelofibrosis               |                      1     1        1                                    |             
      Maxilla, Myelofibrosis               |                2                                   1                     |             
      Thoracic, Vertebra, Myelofibrosis    |       2        2     2     1        2  1              1  1        1      |             
      Tibia, Myelofibrosis                 | 1                                1                                       |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +     +  +  +  +  +  M  +     +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
      Hematopoietic Cell Proliferation     |                   3              3  2                             3      |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
      Cyst                                 |       X                                                                 X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 6| 3| 7| 6| 6| 6| 7| 5| 4| 7| 7| 3| 2| 3| 7| 5| 3| 5| 7| 1| 6| 6| 2|             
                             DAY ON TEST   | 7| 5| 5| 4| 3| 9| 0| 9| 3| 0| 3| 0| 1| 1| 5| 7| 3| 5| 9| 6| 3| 9| 6| 7| 4|             
                                           | 9| 6| 2| 9| 0| 8| 3| 1| 0| 0| 3| 6| 3| 3| 9| 9| 0| 2| 5| 6| 1| 8| 6| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
    SPECIAL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Ectopic Parathyroid Gland            |                   X                                                      |             
      Thymocyte, Necrosis                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  M  +     +  +  +  +|             
      Hyperplasia, Cystic                  |    1                             1                       1        2      |             
      Inflammation, Chronic Active         |                            2                                             |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
      Intervertebral Disc, Degeneration    |                      1              1                                    |             
      Mandible, Inflammation, Suppurative  |                                                                          |             
      Tibia, Osteosclerosis                |                   2                                                      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
      Inflammation, Chronic Active         |                                  2                                       |             
      Leukocytosis                         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                      3                                                   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  M  +     +  +  M     +  +  +  +  +  +  +     +  +  I     +  +  +  +|             
      Hyperplasia                          |                            2                                             |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
      Cyst                                 |                                                                   X      |             
      Mineralization                       | 1                    1     2     1           1     1  1  1        1  1   |             
      Necrosis, Coagulative                |                                                                          |             
      Nephropathy, Chronic                 |       1              1                 1     1     1  1                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 5| 3| 1| 6| 7| 6| 6| 7| 2| 4| 5| 6| 7| 3| 5| 4| 2| 6| 5| 7| 5| 5| 4|            |
                             DAY ON TEST   | 1| 7| 8| 4| 3| 3| 3| 1| 8| 3| 8| 2| 3| 1| 3| 6| 7| 3| 7| 4| 7| 3| 6| 2| 7|            |
                                           | 1| 7| 7| 9| 5| 1| 2| 7| 0| 3| 6| 0| 4| 1| 6| 1| 1| 7| 8| 8| 9| 7| 8| 7| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    SPECIAL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  42        |
      Inflammation, Chronic Active         |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +     +  +     +  +  +  +     +  +  M  +  +  +     +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  42        |
      Lymphoid Tissue, Hyperplasia         |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  42        |
      Basophilic Focus                     |                      X                 X                                 |      6     |
      Clear Cell Focus                     |       X                 X                                                |      2     |
      Eosinophilic Focus                   |                      X  X                                                |      4     |
      Hematopoietic Cell Proliferation     |          2                                                  2            |      2  2.0|
      Hepatodiaphragmatic Nodule           |       X                                                                  |      1     |
      Leukocytosis                         |          X                                         X                     |      2     |
      Necrosis, Coagulative                |       1                                         4  1                     |      4  2.0|
      Pigmentation, Hemosiderin            |       2                                                                  |      1  2.0|
      Vacuolization Cytoplasmic            |                      2           3                 2     2               |      5  2.2|
      Bile Duct, Cyst                      |                                                             X            |      1     |
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +           +                 +                                 |   6        |
      Inflammation, Chronic Active         |          4                                                               |      1  4.0|
      Inflammation, Necrotizing            |                      4                 4                                 |      3  3.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  42        |
      Inflammation, Chronic Active         |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  41        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  42        |
      Diverticulum                         |                                                                   3      |      1  3.0|
      Inflammation, Chronic Active         |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  42        |
      Erosion                              |                                                 2                        |      2  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  42        |
      Dentine, Incisor, Dysplasia          |       1                                                                  |      1  1.0|
      Incisor, Lower, Dysplasia            |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 5| 3| 1| 6| 7| 6| 6| 7| 2| 4| 5| 6| 7| 3| 5| 4| 2| 6| 5| 7| 5| 5| 4|            |
                             DAY ON TEST   | 1| 7| 8| 4| 3| 3| 3| 1| 8| 3| 8| 2| 3| 1| 3| 6| 7| 3| 7| 4| 7| 3| 6| 2| 7|            |
                                           | 1| 7| 7| 9| 5| 1| 2| 7| 0| 3| 6| 0| 4| 1| 6| 1| 1| 7| 8| 8| 9| 7| 8| 7| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    SPECIAL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  41        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  42        |
      Hyperplasia                          |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  41        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +     +  M     +  +  +  +     +  +  +  +  +  M     +  +  +|  37        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  41        |
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  42        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Follicular Cell, Hyperplasia         |                         2           2  2           2                     |      8  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |          M                                                               |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  M  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  41        |
      Atrophy                              |       2        4     3  3                       3           4            |     14  3.3|
      Cyst                                 | X     X              X                                      X     X      |     12     |
      Inflammation, Chronic Active         |                                                    3                     |      1  3.0|
      Necrosis, Coagulative                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  42        |
      Dilatation                           |    4                             4                       4           4  4|     11  3.9|
      Hyperplasia, Cystic, Glandular       | 1  4  4  2     3     3  3     2  3  3  4     3  3  2     1        3  2   |     34  2.6|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  42        |
      Femoral, Myelofibrosis               |                                     1  1                                 |      5  1.0|
      Humerus, Myelofibrosis               |                      1              3  2                             1   |      7  1.4|
      Maxilla, Myelofibrosis               |                                                                   2      |      3  1.7|
      Thoracic, Vertebra, Myelofibrosis    | 1     1     1        2  2     1     3  2     1                    2  2   |     20  1.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 5| 3| 1| 6| 7| 6| 6| 7| 2| 4| 5| 6| 7| 3| 5| 4| 2| 6| 5| 7| 5| 5| 4|            |
                             DAY ON TEST   | 1| 7| 8| 4| 3| 3| 3| 1| 8| 3| 8| 2| 3| 1| 3| 6| 7| 3| 7| 4| 7| 3| 6| 2| 7|            |
                                           | 1| 7| 7| 9| 5| 1| 2| 7| 0| 3| 6| 0| 4| 1| 6| 1| 1| 7| 8| 8| 9| 7| 8| 7| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    SPECIAL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Tibia, Myelofibrosis                 |    2                                                                     |      3  1.3|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  42        |
      Mediastinal, Hyperplasia, Plasma Cell|          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +     +  +     +  +  +  +     +  M  +  +  +  +     +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  42        |
      Hematopoietic Cell Proliferation     |          4           2                 2        4  4        2            |     10  2.9|
      Hyperplasia, Lymphoid                |                3                                                     2  2|      3  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  42        |
      Cyst                                 | X                                                                        |      3     |
      Ectopic Parathyroid Gland            |                                                                          |      1     |
      Thymocyte, Necrosis                  |          3                                                               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  41        |
      Hyperplasia, Cystic                  |                                              1                    1     1|      7  1.1|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  42        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  42        |
      Intervertebral Disc, Degeneration    |                                                                          |      2  1.0|
      Mandible, Inflammation, Suppurative  |                                                             3            |      1  3.0|
      Tibia, Osteosclerosis                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |          +                                                               |   1        |
      Inflammation, Chronic Active         |          4                                                               |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  42        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  42        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Leukocytosis                         |          X                                         X                     |      2     |
      Alveolar Epithelium, Hyperplasia     | 2                                                                        |      2  2.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  42        |
      Inflammation, Chronic Active         |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  42        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 5| 3| 1| 6| 7| 6| 6| 7| 2| 4| 5| 6| 7| 3| 5| 4| 2| 6| 5| 7| 5| 5| 4|            |
                             DAY ON TEST   | 1| 7| 8| 4| 3| 3| 3| 1| 8| 3| 8| 2| 3| 1| 3| 6| 7| 3| 7| 4| 7| 3| 6| 2| 7|            |
                                           | 1| 7| 7| 9| 5| 1| 2| 7| 0| 3| 6| 0| 4| 1| 6| 1| 1| 7| 8| 8| 9| 7| 8| 7| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|      A     |
    SPECIAL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                              +                           |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +     +  +     +  +  +  M     +  +  M  M  +  +     +  +  +|  36        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                             2            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  42        |
      Cyst                                 |                                                                          |      1     |
      Mineralization                       | 1  1  1  1     1        1        1  1  1        1  1     1               |     22  1.0|
      Necrosis, Coagulative                |                                                 3                        |      1  3.0|
      Nephropathy, Chronic                 |    2     1           1                 1                    2     1      |     12  1.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +     +  +     +  +  +  +     +  +  +  +  +  +     +  +  +|  42        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 7| 7| 7| 7| 7| 5| 7| 7| 7| 1| 7| 7| 1| 4| 7| 7| 7| 7| 1| 6| 7| 4| 6|             
                             DAY ON TEST   | 6| 5| 3| 3| 3| 3| 3| 8| 3| 3| 3| 6| 3| 2| 9| 5| 2| 3| 3| 2| 6| 7| 3| 5| 4|             
                                           | 5| 9| 1| 1| 1| 0| 1| 4| 1| 1| 0| 6| 2| 9| 8| 8| 9| 2| 2| 9| 6| 8| 0| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
     25 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  M  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
      Cyst                                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |          X                                                               |             
      Eosinophilic Focus                   |                X           X  X     X  X              X                  |             
      Hematopoietic Cell Proliferation     |                                        2                                 |             
      Hepatodiaphragmatic Nodule           |                                                 X                        |             
      Necrosis, Coagulative                |             4        3                                         4         |             
      Vacuolization Cytoplasmic            |    3                                                                     |             
      Bile Duct, Cyst                      |                               X                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +     +        +  +  +  +     +                                    |             
      Inflammation, Necrotizing            |       4     4           4  4  4     4                                    |             
      Mineralization                       |       2     1                 3     1                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |       2                                                                  |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
      Acanthosis                           |       2                                               3                  |             
      Diverticulum                         |                                                    2                     |             
      Inflammation, Chronic Active         |                            4                          3                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |                                                          2               |             
      Mineralization                       |                         1                                                |             
                                            __________________________________________________________________________|             
   Tooth                                   |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
      Dentine, Incisor, Dysplasia          |             1           1  1        1                    1        1  1   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
      Cardiomyopathy, Chronic              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 7| 7| 7| 7| 7| 5| 7| 7| 7| 1| 7| 7| 1| 4| 7| 7| 7| 7| 1| 6| 7| 4| 6|             
                             DAY ON TEST   | 6| 5| 3| 3| 3| 3| 3| 8| 3| 3| 3| 6| 3| 2| 9| 5| 2| 3| 3| 2| 6| 7| 3| 5| 4|             
                                           | 5| 9| 1| 1| 1| 0| 1| 4| 1| 1| 0| 6| 2| 9| 8| 8| 9| 2| 2| 9| 6| 8| 0| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
     25 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
      Degeneration, Fatty                  |                         3     2                                          |             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |                               2                                          |             
      Capsule, Spindle Cell, Hyperplasia   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
      Hyperplasia                          |                               3                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
      Pars Distalis, Hyperplasia           |       2        2                       2           2  3  2              2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
      Inflammation, Chronic Active         |       1                                                                  |             
      Ultimobranchial Cyst                 |                                                                          |             
      Follicular Cell, Hyperplasia         |       2     1  2  2     3     1     2              3  2  2               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
      Atrophy                              |       2  2     2  2  3  1  2        2  2        3  2  3  2     3  2     4|             
      Cyst                                 |    X        X     X  X     X        X  X     X        X              X  X|             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                                                       X                  |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
      Dilatation                           |                               4                                         4|             
      Hyperplasia, Cystic, Glandular       |    4  4  4  2  2  3  2  2  4  4        4  1  2  3  3  4  3     2  2  3  2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Myelofibrosis               |       2  1  1  2  2  1  2  2        1  1     1  1  1  1  2        2      |             
      Humerus, Myelofibrosis               |    1  1                    1        1           2  1  2        1  1      |             
      Maxilla, Myelofibrosis               |       1  1  2     2  2  2     2        1        1     2  1        1      |             
      Thoracic, Vertebra, Myelofibrosis    | 1  1  1  2  1  1  3     2  1  3     2  2     1  3  3  1  3  1  2  2     1|             
      Tibia, Myelofibrosis                 |       2     2              1                       1  2  1     1        1|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  M  +  +  M  +  +  +  +  +     +  +  +  +  M  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 7| 7| 7| 7| 7| 5| 7| 7| 7| 1| 7| 7| 1| 4| 7| 7| 7| 7| 1| 6| 7| 4| 6|             
                             DAY ON TEST   | 6| 5| 3| 3| 3| 3| 3| 8| 3| 3| 3| 6| 3| 2| 9| 5| 2| 3| 3| 2| 6| 7| 3| 5| 4|             
                                           | 5| 9| 1| 1| 1| 0| 1| 4| 1| 1| 0| 6| 2| 9| 8| 8| 9| 2| 2| 9| 6| 8| 0| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
     25 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
      Hematopoietic Cell Proliferation     |       3     3  2        2                          2                    4|             
      Hyperplasia, Lymphoid                |          3        4                                      3               |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  M  +  M  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
      Cyst                                 |       X                       X                 X                        |             
      Hyperplasia, Lymphoid                |       2                                         2                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
      Hyperplasia, Cystic                  |             2                       1           2     2                  |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
      Cyst Epithelial Inclusion            |                X                                                         |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
      Humerus, Periosteum, Proliferation,  |                                                                          |             
           Focal                           |                                                                          |             
      Intervertebral Disc, Degeneration    |                      2              1           2  1                    2|             
      Periosteum, Maxilla, Proliferation,  |                                                                          |             
           Focal                           |                                                                         2|             
      Rib, Cartilage, Degeneration         |                                                                          |             
      Thoracic, Vertebra, Osteosclerosis   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
      Compression                          |                                                                          |             
      Hydrocephalus                        |                                                                          |             
      Neuron, Necrosis                     |                                                                          |             
      White Matter, Degeneration           |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
      Sciatic, Degeneration                |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
      Inflammation, Chronic Active         |                                     2                                    |             
      Mineralization                       |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 7| 7| 7| 7| 7| 5| 7| 7| 7| 1| 7| 7| 1| 4| 7| 7| 7| 7| 1| 6| 7| 4| 6|             
                             DAY ON TEST   | 6| 5| 3| 3| 3| 3| 3| 8| 3| 3| 3| 6| 3| 2| 9| 5| 2| 3| 3| 2| 6| 7| 3| 5| 4|             
                                           | 5| 9| 1| 1| 1| 0| 1| 4| 1| 1| 0| 6| 2| 9| 8| 8| 9| 2| 2| 9| 6| 8| 0| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
     25 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                     +                                    |             
      Phthisis Bulbi                       |                                                                          |             
      Lens, Cataract                       |                                     3                                    |             
      Retina, Atrophy                      |                                     3                                    |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +  M  M  +  +  +  +  +  +  +     +  M  +  +  M  +  +  +     +  +  +  +|             
      Hyperplasia                          |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
      Cyst                                 |          X                                                               |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |          1        1        1  1        1        1  1  1  1     1         |             
      Nephropathy, Chronic                 |       2  2  2  1  1        1        1  1  1     1  1  3  1     2  1  1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 7| 7| 7| 1| 6| 6| 7| 7| 7| 7| 1| 1| 7| 6| 7| 4| 7| 7| 7| 7| 1|             
                             DAY ON TEST   | 5| 3| 3| 3| 2| 3| 3| 6| 2| 5| 3| 2| 3| 3| 6| 6| 3| 1| 2| 5| 3| 3| 3| 3| 6|             
                                           | 9| 6| 2| 2| 9| 2| 3| 6| 4| 2| 3| 9| 3| 3| 6| 5| 3| 7| 9| 8| 3| 6| 6| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
     25 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
      Basophilic Focus                     |                                  X                                       |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |       X     X     X           X  X     X        X           X  X         |             
      Hematopoietic Cell Proliferation     |                                  2                                       |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Vacuolization Cytoplasmic            |    1                                                                     |             
      Bile Duct, Cyst                      |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +     +     +                                   +                        |             
      Inflammation, Necrotizing            | 4     4     4                                   4                        |             
      Mineralization                       |       2                                         2                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
      Acanthosis                           |          2                                         2                     |             
      Diverticulum                         |                                                                          |             
      Inflammation, Chronic Active         |          2                                         2                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
      Cyst                                 |                                                             X            |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
      Dentine, Incisor, Dysplasia          |       1     1  1              1                       1  1  1     1      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
      Cardiomyopathy, Chronic              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 7| 7| 7| 1| 6| 6| 7| 7| 7| 7| 1| 1| 7| 6| 7| 4| 7| 7| 7| 7| 1|             
                             DAY ON TEST   | 5| 3| 3| 3| 2| 3| 3| 6| 2| 5| 3| 2| 3| 3| 6| 6| 3| 1| 2| 5| 3| 3| 3| 3| 6|             
                                           | 9| 6| 2| 2| 9| 2| 3| 6| 4| 2| 3| 9| 3| 3| 6| 5| 3| 7| 9| 8| 3| 6| 6| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
     25 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
      Degeneration, Fatty                  |                                                    2                     |             
      Fibrosis                             |                                                                      2   |             
      Hyperplasia                          |                                        2                                 |             
      Hypertrophy                          |                                                                          |             
      Capsule, Spindle Cell, Hyperplasia   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +     +  +  +  +  +  M        +  +  +  +  +  +  +  +   |             
      Cyst                                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  M  +  +   |             
      Pars Distalis, Hyperplasia           |    3  2     3                 3  2  3           2                 2      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic Active         |                                                                          |             
      Ultimobranchial Cyst                 |                                                             X            |             
      Follicular Cell, Hyperplasia         |    3  2     2  2  2        1  2                 1     2     1     2  2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | I  +  +  +  I  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
      Atrophy                              |       2  2     2  2           2  2  2  2        3     2     2  2  2  2   |             
      Cyst                                 |       X  X     X  X        X  X  X  X              X              X  X   |             
      Mineralization                       |          3                                                               |             
      Thrombosis                           |          X                                                               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
      Dilatation                           |                   4     4                       4     4              4   |             
      Hyperplasia, Cystic, Glandular       | 3  4  2  4  2  2  4           4  4  2  2        2  2     3  4  2  3  3   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
      Femoral, Myelofibrosis               | 2        2  2  1  1              1  1           1     1     1        2   |             
      Humerus, Myelofibrosis               |       2  2              2  2  1     2           2     1     1     1  1   |             
      Maxilla, Myelofibrosis               |          3                          1                 2     1     2  2   |             
      Thoracic, Vertebra, Myelofibrosis    |    1  2  3  2  2  1     2  1  2  2  2           2  1  3  1  2  2  3  3   |             
      Tibia, Myelofibrosis                 | 1  1     2                          1                 1     1        1   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 7| 7| 7| 1| 6| 6| 7| 7| 7| 7| 1| 1| 7| 6| 7| 4| 7| 7| 7| 7| 1|             
                             DAY ON TEST   | 5| 3| 3| 3| 2| 3| 3| 6| 2| 5| 3| 2| 3| 3| 6| 6| 3| 1| 2| 5| 3| 3| 3| 3| 6|             
                                           | 9| 6| 2| 2| 9| 2| 3| 6| 4| 2| 3| 9| 3| 3| 6| 5| 3| 7| 9| 8| 3| 6| 6| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
     25 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
      Hematopoietic Cell Proliferation     |          2  3              3                                         3   |             
      Hyperplasia, Lymphoid                |                                     3  3                          3  3   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
      Cyst                                 |    X     X                             X                                 |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
      Hyperplasia, Cystic                  |                2                       1        1                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Inflammation, Chronic Active         |                            4                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
      Humerus, Periosteum, Proliferation,  |                                                                          |             
           Focal                           |                               2                                          |             
      Intervertebral Disc, Degeneration    |             2  2                 2                    2              2   |             
      Periosteum, Maxilla, Proliferation,  |                                                                          |             
           Focal                           |                                                                          |             
      Rib, Cartilage, Degeneration         |                                                                          |             
      Thoracic, Vertebra, Osteosclerosis   |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
      Compression                          |                                                                          |             
      Hydrocephalus                        |                                                                          |             
      Neuron, Necrosis                     |                                                                          |             
      White Matter, Degeneration           |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |    +                                                                     |             
      Sciatic, Degeneration                |    3                                                                     |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic Active         |          2                                            2                  |             
      Mineralization                       |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                       2           2  2   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 7| 7| 7| 1| 6| 6| 7| 7| 7| 7| 1| 1| 7| 6| 7| 4| 7| 7| 7| 7| 1|             
                             DAY ON TEST   | 5| 3| 3| 3| 2| 3| 3| 6| 2| 5| 3| 2| 3| 3| 6| 6| 3| 1| 2| 5| 3| 3| 3| 3| 6|             
                                           | 9| 6| 2| 2| 9| 2| 3| 6| 4| 2| 3| 9| 3| 3| 6| 5| 3| 7| 9| 8| 3| 6| 6| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
     25 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                   +      |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Phthisis Bulbi                       |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | M  M  M  +  M  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
      Hyperplasia                          |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
      Cyst                                 |                                                 X                        |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |    1  1  1  1     1           1  1  1  1        1  1  1     1  1  1      |             
      Nephropathy, Chronic                 | 1     2     1  1           1  1  1  1  1           1  1  2  1  1     1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +     +  +  +  +  +  +        +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 6| 5| 4| 6| 7| 1| 5| 3| 7| 1| 7| 5| 7| 4| 7| 1| 7| 7|              |            |
                             DAY ON TEST   | 3| 5| 7| 3| 5| 9| 3| 6| 8| 9| 3| 6| 3| 3| 3| 5| 3| 6| 3| 2|              |            |
                                           | 6| 8| 0| 4| 8| 8| 6| 5| 7| 5| 7| 6| 7| 4| 7| 9| 7| 5| 7| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|              |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|              |      A     |
     25 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  59        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  60        |
      Basophilic Focus                     |                                                                          |      1     |
      Clear Cell Focus                     |                                                          X               |      2     |
      Eosinophilic Focus                   | X           X     X     X           X  X              X                  |     22     |
      Hematopoietic Cell Proliferation     |                                                       2                  |      3  2.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Necrosis, Coagulative                |                         1                                                |      4  3.0|
      Vacuolization Cytoplasmic            |       4                       2                                          |      4  2.5|
      Bile Duct, Cyst                      |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Mesentery                               | M              +        +  +        +                    +               |  16        |
      Inflammation, Necrotizing            |                4        3           4                                    |     13  3.9|
      Mineralization                       |                                     2                                    |      7  1.9|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  60        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  60        |
      Acanthosis                           |       3                                               3                  |      6  2.5|
      Diverticulum                         |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |       2                                                                  |      5  2.6|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  60        |
      Cyst                                 |                                                                          |      1     |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  60        |
      Dentine, Incisor, Dysplasia          | 1     1        1  1           1                          1               |     21  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 6| 5| 4| 6| 7| 1| 5| 3| 7| 1| 7| 5| 7| 4| 7| 1| 7| 7|              |            |
                             DAY ON TEST   | 3| 5| 7| 3| 5| 9| 3| 6| 8| 9| 3| 6| 3| 3| 3| 5| 3| 6| 3| 2|              |            |
                                           | 6| 8| 0| 4| 8| 8| 6| 5| 7| 5| 7| 6| 7| 4| 7| 9| 7| 5| 7| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|              |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|              |      A     |
     25 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  60        |
      Cardiomyopathy, Chronic              |                                                       2                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  60        |
      Degeneration, Fatty                  |                                                                          |      3  2.3|
      Fibrosis                             |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Hypertrophy                          |                                                                          |      1  2.0|
      Capsule, Spindle Cell, Hyperplasia   |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  60        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  59        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  59        |
      Pars Distalis, Hyperplasia           |                   3                 2     2     2        2               |     20  2.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  60        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Ultimobranchial Cyst                 |                                                                          |      1     |
      Follicular Cell, Hyperplasia         | 2                 1                 2     1           1                  |     27  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +                       +                                                |   2        |
      Duct, Dilatation                     |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +     +  +  +     +  +  +  +  M     +  +               |  57        |
      Atrophy                              | 1     2           2           4     3     3           2  2               |     38  2.2|
      Cyst                                 |          X              X                 X                              |     25     |
      Mineralization                       |                                                                          |      1  3.0|
      Thrombosis                           |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  60        |
      Dilatation                           | 4     3  3  4     4     3                       4                        |     14  3.8|
      Hyperplasia, Cystic, Glandular       | 2  4  2     3  2  3     4  3  3     2     4  3  3     3  3               |     54  2.9|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 6| 5| 4| 6| 7| 1| 5| 3| 7| 1| 7| 5| 7| 4| 7| 1| 7| 7|              |            |
                             DAY ON TEST   | 3| 5| 7| 3| 5| 9| 3| 6| 8| 9| 3| 6| 3| 3| 3| 5| 3| 6| 3| 2|              |            |
                                           | 6| 8| 0| 4| 8| 8| 6| 5| 7| 5| 7| 6| 7| 4| 7| 9| 7| 5| 7| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|              |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|              |      A     |
     25 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  62        |
      Femoral, Myelofibrosis               | 1        1        1                 2     2     1     2                  |     34  1.4|
      Humerus, Myelofibrosis               | 1     1           2                 1     1     2        2               |     27  1.4|
      Maxilla, Myelofibrosis               |                                              1           1               |     20  1.6|
      Thoracic, Vertebra, Myelofibrosis    | 3  2  1  3        1                 2     2  2  2        2               |     50  1.9|
      Tibia, Myelofibrosis                 |          1                                                               |     16  1.3|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  57        |
      Sinus, Ectasia                       |                                                 4                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  60        |
      Hematopoietic Cell Proliferation     |                2           3  3                 3        3               |     15  2.7|
      Hyperplasia, Lymphoid                |                                                                          |      7  3.1|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  +     +  I  +     +  +  +  +  +     +  +               |  56        |
      Cyst                                 |                                                                          |      6     |
      Hyperplasia, Lymphoid                |                   2                                                      |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +     +  M  +     +  +  +  +  +     +  +               |  59        |
      Hyperplasia, Cystic                  |                                        2                                 |      8  1.6|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  60        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Inflammation, Chronic Active         |                         4                                                |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  60        |
      Humerus, Periosteum, Proliferation,  |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Intervertebral Disc, Degeneration    |                                        2        2     2                  |     13  1.8|
      Periosteum, Maxilla, Proliferation,  |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Rib, Cartilage, Degeneration         | 3                                                                        |      1  3.0|
      Thoracic, Vertebra, Osteosclerosis   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  60        |
      Compression                          |                X                       X                                 |      2     |
      Hydrocephalus                        |                                        3                                 |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 6| 5| 4| 6| 7| 1| 5| 3| 7| 1| 7| 5| 7| 4| 7| 1| 7| 7|              |            |
                             DAY ON TEST   | 3| 5| 7| 3| 5| 9| 3| 6| 8| 9| 3| 6| 3| 3| 3| 5| 3| 6| 3| 2|              |            |
                                           | 6| 8| 0| 4| 8| 8| 6| 5| 7| 5| 7| 6| 7| 4| 7| 9| 7| 5| 7| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|              |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|              |      A     |
     25 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Neuron, Necrosis                     |       2                                                                  |      1  2.0|
      White Matter, Degeneration           |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
      Sciatic, Degeneration                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  60        |
      Inflammation, Chronic Active         |                   2                                                      |      4  2.0|
      Mineralization                       |                                     1                                    |      1  1.0|
      Pigmentation, Hemosiderin            |                   2                                                      |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  60        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +     +  +  M     +  +  +  +  +     +  +               |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                            +                                             |   2        |
      Phthisis Bulbi                       |                            X                                             |      1     |
      Lens, Cataract                       |                                                                          |      1  3.0|
      Retina, Atrophy                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  M  M  +  +  M  +     +  M  +     +  +  +  +  +     +  +               |  48        |
      Hyperplasia                          |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  60        |
      Cyst                                 |                                                                          |      2     |
      Metaplasia, Osseous                  |                               2                                          |      1  2.0|
      Mineralization                       | 1     1           1     1     1     1     1     1     1                  |     34  1.0|
      Nephropathy, Chronic                 | 1  1  1     1     1           3     1  1  1     1     3  1               |     43  1.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +     +  +  +     +  +  +  +  +     +  +               |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 4| 1| 7| 7| 6| 1| 7| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 1|             
                             DAY ON TEST   | 5| 8| 5| 6| 3| 3| 5| 6| 3| 1| 5| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 6|             
                                           | 8| 7| 9| 5| 1| 1| 3| 5| 1| 3| 9| 1| 4| 0| 2| 0| 2| 0| 0| 2| 2| 1| 0| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
     100 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  A   |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +  +  +     +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  A   |             
      Inflammation, Chronic Active         |    4                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                             X            |             
      Eosinophilic Focus                   |                               X        X                                 |             
      Hematopoietic Cell Proliferation     |                                                                   2      |             
      Inflammation, Chronic Active         |                         2                                                |             
      Mineralization                       |                                                                          |             
      Necrosis, Coagulative                |                   2                 3                                    |             
      Pigmentation, Hemosiderin            |                         2                                                |             
      Vacuolization Cytoplasmic            | 2                 3                                                      |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +           +              +     +           +        +               |             
      Inflammation, Necrotizing            | 3  4           3              4                 4        4               |             
      Mineralization                       |                3                                                         |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A   |             
      Acinus, Atrophy                      |                         3        1                                       |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A   |             
      Acanthosis                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A   |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Dentine, Incisor, Dysplasia          |             1           1        1  1  1        1        1  1     1      |             
      Dentine, Incisor, Necrosis           |                                                                          |             
      Incisor, Ameloblast, Atrophy         |                                                                          |             
      Incisor, Ameloblast, Degeneration    |                                                                          |             
      Peridontal Tissue, Incisor,          |                                                                          |             
          Inflammation, Suppurative        |    4                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 4| 1| 7| 7| 6| 1| 7| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 1|             
                             DAY ON TEST   | 5| 8| 5| 6| 3| 3| 5| 6| 3| 1| 5| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 6|             
                                           | 8| 7| 9| 5| 1| 1| 3| 5| 1| 3| 9| 1| 4| 0| 2| 0| 2| 0| 0| 2| 2| 1| 0| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
     100 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Cardiomyopathy, Chronic              |                                                                          |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Cyst                                 |                                                                          |             
      Degeneration, Fatty                  |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hypertrophy                          |                                                                          |             
      Capsule, Spindle Cell, Hyperplasia   |                   3                                                      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +     +  +  +     M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Craniopharyngeal Duct, Pars Distalis,|                                                                          |             
           Cyst                            |                                                                          |             
      Craniopharyngeal Duct, Pars Distalis,|                                                                          |             
           Inflammation, Suppurative       |                                                                          |             
      Pars Distalis, Cyst                  |                                  X                                       |             
      Pars Distalis, Hyperplasia           |             4  3                          2  2     2  2  2  2     2      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic Active         |                         1                                                |             
      Ultimobranchial Cyst                 |                                                                          |             
      Follicular Cell, Hyperplasia         |                1                       2  2     2  2     2  2     2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Atrophy                              |             3  2  3              2     2  3  2  2  2  3  2  2  3  2      |             
      Cyst                                 |                         X        X     X  X        X     X  X     X  X   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Dilatation                           |                         4                                      3         |             
      Hyperplasia, Cystic, Glandular       | 2  2  2     2  2  2     2  3  4  3  2  4  4  2  4  3  1  3  4  2  2  2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 4| 1| 7| 7| 6| 1| 7| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 1|             
                             DAY ON TEST   | 5| 8| 5| 6| 3| 3| 5| 6| 3| 1| 5| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 6|             
                                           | 8| 7| 9| 5| 1| 1| 3| 5| 1| 3| 9| 1| 4| 0| 2| 0| 2| 0| 0| 2| 2| 1| 0| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
     100 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Femoral, Myelofibrosis               |             2  1  2  1  1        1     1  1  1  1  1  1  1        1  1   |             
      Humerus, Myelofibrosis               | 3     1                       2  1           1  3     2  1  2            |             
      Maxilla, Myelofibrosis               |                1                          2     1  1  1  3        1      |             
      Thoracic, Vertebra, Myelofibrosis    | 1     1     2  2        1  1  2  2     2  2  3  2  2  2  2  2  1  2      |             
      Tibia, Myelofibrosis                 |                                                          2               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Renal, Sinus, Ectasia                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +     +  +  +     +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Sinus, Ectasia                       |                         4                                                |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +     +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Depletion Lymphoid                   |                         2                                                |             
      Fibrosis                             |                         3                                                |             
      Hematopoietic Cell Proliferation     |    4              3     2                       2           2        4   |             
      Hyperplasia, Lymphoid                |                                        4              3           3      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Cyst                                 | X                             X                                          |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hyperplasia, Cystic                  |    1           1  2                       2              1               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Alopecia                             |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Intervertebral Disc, Degeneration    |                   3                                                      |             
      Rib, Cartilage, Degeneration         |                3                                                         |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Compression                          |                                                                          |             
      Hydrocephalus                        |                                                                          |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
      Sciatic, Degeneration                |                                                                          |             
      Spinal, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      White Matter, Degeneration           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 4| 1| 7| 7| 6| 1| 7| 3| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 4| 1|             
                             DAY ON TEST   | 5| 8| 5| 6| 3| 3| 5| 6| 3| 1| 5| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 1| 6|             
                                           | 8| 7| 9| 5| 1| 1| 3| 5| 1| 3| 9| 1| 4| 0| 2| 0| 2| 0| 0| 2| 2| 1| 0| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
     100 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic Active         |                                                                          |             
      Leukocytosis                         |                                                                          |             
      Mineralization                       |                                                          2               |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic Active         |    2                                                                     |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                           2                              |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Middle Ear, Inflammation, Suppurative|                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  M  +     +  +  M     +  +  +  +  +  +  +  M  +  +  +  +  M  M  +  +   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hydronephrosis                       |                                                                          |             
      Metaplasia, Osseous                  |                2                                                         |             
      Mineralization                       |             1     1     1           1  1  1  1  1  1        1            |             
      Nephropathy, Chronic                 | 1           1           1        1     1     1        1  1  1     1      |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 1| 7| 1| 1| 1| 6| 7| 3| 7| 7| 7| 6| 6| 4| 7| 7| 7| 4| 4| 4| 7| 1| 7|             
                             DAY ON TEST   | 3| 2| 6| 3| 6| 6| 6| 5| 2| 7| 3| 3| 3| 1| 9| 5| 3| 3| 3| 5| 5| 5| 3| 6| 3|             
                                           | 0| 7| 5| 2| 6| 5| 5| 7| 4| 9| 3| 3| 3| 7| 2| 8| 3| 3| 6| 8| 9| 9| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
                               ANIMAL ID   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
     100 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Inflammation, Chronic Active         |                                        3                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                                                         X|             
      Clear Cell Focus                     |                      X                                                   |             
      Eosinophilic Focus                   |                                     X        X  X  X                     |             
      Hematopoietic Cell Proliferation     |                                                                   3      |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis, Coagulative                |                      4  4  2           3                          2      |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Vacuolization Cytoplasmic            |                      2                 4           2                     |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +                 +        +  +                  |             
      Inflammation, Necrotizing            |                         3                 4        4  4                  |             
      Mineralization                       |                                                                          |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Acinus, Atrophy                      |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Acanthosis                           |    3                                   2                                 |             
      Inflammation, Chronic Active         |    2                                   4                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Dentine, Incisor, Dysplasia          | 2        1              1  1              1  1  1     1                 1|             
      Dentine, Incisor, Necrosis           | 2                                                                        |             
      Incisor, Ameloblast, Atrophy         |                                                                          |             
      Incisor, Ameloblast, Degeneration    |                      2                                                   |             
      Peridontal Tissue, Incisor,          |                                                                          |             
          Inflammation, Suppurative        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 1| 7| 1| 1| 1| 6| 7| 3| 7| 7| 7| 6| 6| 4| 7| 7| 7| 4| 4| 4| 7| 1| 7|             
                             DAY ON TEST   | 3| 2| 6| 3| 6| 6| 6| 5| 2| 7| 3| 3| 3| 1| 9| 5| 3| 3| 3| 5| 5| 5| 3| 6| 3|             
                                           | 0| 7| 5| 2| 6| 5| 5| 7| 4| 9| 3| 3| 3| 7| 2| 8| 3| 3| 6| 8| 9| 9| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
                               ANIMAL ID   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
     100 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Cardiomyopathy, Chronic              |                            2                                             |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Cyst                                 |                                                                          |             
      Degeneration, Fatty                  |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                   2      |             
      Hypertrophy                          |                               2                                          |             
      Capsule, Spindle Cell, Hyperplasia   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +     +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Craniopharyngeal Duct, Pars Distalis,|                                                                          |             
           Cyst                            |    X                                                                     |             
      Craniopharyngeal Duct, Pars Distalis,|                                                                          |             
           Inflammation, Suppurative       |    4                                                                     |             
      Pars Distalis, Cyst                  |          X                    X                                          |             
      Pars Distalis, Hyperplasia           |          2                                            2           2     2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Inflammation, Chronic Active         |                                                       2                  |             
      Ultimobranchial Cyst                 |                                                             X            |             
      Follicular Cell, Hyperplasia         | 2                             2  2     2        2  2  2           2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +     +|             
      Atrophy                              | 2  3     2           3  3     3  2  3           2  2  2           4     2|             
      Cyst                                 |                      X        X     X  X                                 |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Dilatation                           |                               4     4                                   4|             
      Hyperplasia, Cystic, Glandular       | 3  1     2           3  2  4  2  2  3  2     3  3  2  2     2  2        2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 1| 7| 1| 1| 1| 6| 7| 3| 7| 7| 7| 6| 6| 4| 7| 7| 7| 4| 4| 4| 7| 1| 7|             
                             DAY ON TEST   | 3| 2| 6| 3| 6| 6| 6| 5| 2| 7| 3| 3| 3| 1| 9| 5| 3| 3| 3| 5| 5| 5| 3| 6| 3|             
                                           | 0| 7| 5| 2| 6| 5| 5| 7| 4| 9| 3| 3| 3| 7| 2| 8| 3| 3| 6| 8| 9| 9| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
                               ANIMAL ID   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
     100 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Femoral, Myelofibrosis               | 1        1           1  1     1  1  1           1  1  1  1               |             
      Humerus, Myelofibrosis               | 2        2              2     1              1  3  1  2     2           2|             
      Maxilla, Myelofibrosis               | 1        1           2  1  1        2     1     2                       2|             
      Thoracic, Vertebra, Myelofibrosis    | 3        3           1  3     2  3  3  2     1  2  1  3  1     1        2|             
      Tibia, Myelofibrosis                 |          1              1     1     1           1                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Renal, Sinus, Ectasia                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +     M           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +           +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +     +|             
      Sinus, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Depletion Lymphoid                   |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |    2                                2                             4      |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +     +           +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M     +|             
      Cyst                                 |                                                                          |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Hyperplasia, Cystic                  |    1                    2                                                |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Alopecia                             |                                                                          |             
      Inflammation, Chronic Active         |                                           3                              |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Intervertebral Disc, Degeneration    |    2     2                    3                 1                 2      |             
      Rib, Cartilage, Degeneration         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Compression                          |    X                                                                     |             
      Hydrocephalus                        |    3                                                                     |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                      +                                                   |             
      Sciatic, Degeneration                |                                                                          |             
      Spinal, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                      +                                                   |             
      White Matter, Degeneration           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 1| 7| 1| 1| 1| 6| 7| 3| 7| 7| 7| 6| 6| 4| 7| 7| 7| 4| 4| 4| 7| 1| 7|             
                             DAY ON TEST   | 3| 2| 6| 3| 6| 6| 6| 5| 2| 7| 3| 3| 3| 1| 9| 5| 3| 3| 3| 5| 5| 5| 3| 6| 3|             
                                           | 0| 7| 5| 2| 6| 5| 5| 7| 4| 9| 3| 3| 3| 7| 2| 8| 3| 3| 6| 8| 9| 9| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
                               ANIMAL ID   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
     100 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Inflammation, Chronic Active         |                                        1                                 |             
      Leukocytosis                         |                                                                   X      |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Inflammation, Chronic Active         |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |    +                       I                                             |             
      Middle Ear, Inflammation, Suppurative|    4                                                                     |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                       +              +   |             
      Cornea, Inflammation, Chronic Active |                                                       3                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +     +           +  +  M  +  +  +  +  M  +  +  M  +  +  M  +  M     +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Hydronephrosis                       |                                           4                              |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       | 1                    1  1              1              1           1     1|             
      Nephropathy, Chronic                 | 1        1           2  3     1  1  1  3              1                 1|             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +           +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 4| 7| 7| 7| 6| 7| 7| 4| 6| 4| 7| 7| 7| 1| 7| 5| 1| 7|              |            |
                             DAY ON TEST   | 7| 3| 5| 3| 3| 3| 8| 3| 3| 5| 3| 5| 3| 3| 3| 6| 3| 5| 6| 3|              |            |
                                           | 8| 6| 8| 6| 0| 6| 4| 0| 0| 9| 4| 9| 7| 7| 7| 6| 0| 2| 5| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|              |      A     |
     100 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  60        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  58        |
      Artery, Necrosis, Fibrinoid          |                                                    4                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  58        |
      Inflammation, Chronic Active         |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  59        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  60        |
      Angiectasis                          |                                                 2                        |      1  2.0|
      Basophilic Focus                     |    X              X                                                      |      3     |
      Clear Cell Focus                     |                                                                          |      2     |
      Eosinophilic Focus                   |          X     X        X        X     X                                 |     11     |
      Hematopoietic Cell Proliferation     |                         1                                                |      3  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Mineralization                       |          3                                                               |      1  3.0|
      Necrosis, Coagulative                |          4  4                                                            |      9  3.1|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |       2                          3                                       |      7  2.6|
      Artery, Necrosis, Fibrinoid          |                                                    4                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +           +  +        +        +     +  +                     |  18        |
      Inflammation, Necrotizing            |          4           4  4                       4                        |     14  3.8|
      Mineralization                       |          2           2  3                       2                        |      5  2.4|
      Artery, Necrosis, Fibrinoid          |                                                    4                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  59        |
      Acinus, Atrophy                      |                      2                    2                              |      4  2.0|
      Duct, Ectasia                        |                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  60        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  59        |
      Acanthosis                           |                   2                       3              3               |      5  2.6|
      Inflammation, Chronic Active         |                                                          2               |      3  2.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  59        |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  60        |
      Dentine, Incisor, Dysplasia          | 1                    2  1                          1     1               |     23  1.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 4| 7| 7| 7| 6| 7| 7| 4| 6| 4| 7| 7| 7| 1| 7| 5| 1| 7|              |            |
                             DAY ON TEST   | 7| 3| 5| 3| 3| 3| 8| 3| 3| 5| 3| 5| 3| 3| 3| 6| 3| 5| 6| 3|              |            |
                                           | 8| 6| 8| 6| 0| 6| 4| 0| 0| 9| 4| 9| 7| 7| 7| 6| 0| 2| 5| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|              |      A     |
     100 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Dentine, Incisor, Necrosis           |                      2                                                   |      2  2.0|
      Incisor, Ameloblast, Atrophy         |                   4                                                      |      1  4.0|
      Incisor, Ameloblast, Degeneration    |                                                                          |      1  2.0|
      Peridontal Tissue, Incisor,          |                                                                          |            |
          Inflammation, Suppurative        |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                    +                     |   1        |
      Artery, Necrosis, Fibrinoid          |                                                    4                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  60        |
      Cardiomyopathy, Chronic              |                                                                          |      1  2.0|
      Artery, Necrosis, Fibrinoid          |                                                    4                     |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  60        |
      Cyst                                 |                         X                                                |      1     |
      Degeneration, Fatty                  |                                                          3               |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hypertrophy                          |    2     2  2                                                            |      4  2.0|
      Capsule, Spindle Cell, Hyperplasia   |                      3        3                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  60        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  59        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +     +  +     +               |  57        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  61        |
      Craniopharyngeal Duct, Pars Distalis,|                                                                          |            |
           Cyst                            |                                                                          |      1     |
      Craniopharyngeal Duct, Pars Distalis,|                                                                          |            |
           Inflammation, Suppurative       |                                                                          |      1  4.0|
      Pars Distalis, Cyst                  |             X                                                            |      4     |
      Pars Distalis, Hyperplasia           |    2        2           2                                                |     16  2.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  60        |
      Inflammation, Chronic Active         |                                                                          |      2  1.5|
      Ultimobranchial Cyst                 |                                                                          |      1     |
      Follicular Cell, Hyperplasia         |    2        2        2  2           2  1        2        4               |     24  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 4| 7| 7| 7| 6| 7| 7| 4| 6| 4| 7| 7| 7| 1| 7| 5| 1| 7|              |            |
                             DAY ON TEST   | 7| 3| 5| 3| 3| 3| 8| 3| 3| 5| 3| 5| 3| 3| 3| 6| 3| 5| 6| 3|              |            |
                                           | 8| 6| 8| 6| 0| 6| 4| 0| 0| 9| 4| 9| 7| 7| 7| 6| 0| 2| 5| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|              |      A     |
     100 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +     +  +     +               |  58        |
      Atrophy                              |    2     4  2  4  4  3  2           2  2  2     2        2               |     39  2.5|
      Cyst                                 |             X                 X                          X               |     16     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  60        |
      Dilatation                           |                   4                                                      |      6  3.8|
      Hyperplasia, Cystic, Glandular       | 1  4  2  2  3  2  3  2  3  4  3  2  3  2  3     2        3               |     56  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  61        |
      Femoral, Myelofibrosis               |       2     1  1     1        1        2        1        2               |     34  1.1|
      Humerus, Myelofibrosis               |    2     1  2              2           2        2  1                     |     26  1.8|
      Maxilla, Myelofibrosis               |                      2              1  2  2              2               |     21  1.5|
      Thoracic, Vertebra, Myelofibrosis    | 1  3  1  1  3  1     2  1  1  3     2  3  2     2  1     2               |     49  1.9|
      Tibia, Myelofibrosis                 |    1        2                                   1                        |      9  1.2|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  60        |
      Renal, Sinus, Ectasia                |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  M     +  +     +               |  56        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  57        |
      Sinus, Ectasia                       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  59        |
      Depletion Lymphoid                   |                                                                          |      1  2.0|
      Fibrosis                             |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |          3                          2  2        2  2     2               |     15  2.5|
      Hyperplasia, Lymphoid                |             3           3              3        2                        |      7  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  M  +  +  +  +  +  +  +  +     +  +     +               |  55        |
      Cyst                                 |       X                       X                                          |      4     |
      Artery, Necrosis, Fibrinoid          |                                                    4                     |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  60        |
      Hyperplasia, Cystic                  |                                                          1               |      8  1.4|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  60        |
      Alopecia                             |                                                    X                     |      1     |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Artery, Necrosis, Fibrinoid          |                                                    4                     |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 4| 7| 7| 7| 6| 7| 7| 4| 6| 4| 7| 7| 7| 1| 7| 5| 1| 7|              |            |
                             DAY ON TEST   | 7| 3| 5| 3| 3| 3| 8| 3| 3| 5| 3| 5| 3| 3| 3| 6| 3| 5| 6| 3|              |            |
                                           | 8| 6| 8| 6| 0| 6| 4| 0| 0| 9| 4| 9| 7| 7| 7| 6| 0| 2| 5| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|              |      A     |
     100 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Intervertebral Disc, Degeneration    |                2                    2                                    |      8  2.1|
      Rib, Cartilage, Degeneration         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  60        |
      Compression                          |                X                                                         |      2     |
      Hydrocephalus                        |                                                                          |      1  3.0|
      Artery, Necrosis, Fibrinoid          |                                                    4                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        | +                                                  +                     |   3        |
      Sciatic, Degeneration                | 3                                                                        |      1  3.0|
      Spinal, Degeneration                 |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +                                                  +                     |   3        |
      White Matter, Degeneration           | 3                                                                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  60        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Leukocytosis                         |                                                                          |      1     |
      Mineralization                       |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                 1                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  60        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |             2     2                                                      |      3  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
      Middle Ear, Inflammation, Suppurative|                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |             +                                                            |   3        |
      Cornea, Inflammation, Chronic Active |             2                                                            |      2  2.5|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  M  +  +  +  M  M  +  +  +  +  +  +  M     I  +     +               |  45        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  60        |
      Hydronephrosis                       |                                                                          |      1  4.0|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
      Mineralization                       |    1        1  1     1  1     1     1     1     1                        |     26  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 4| 7| 7| 7| 6| 7| 7| 4| 6| 4| 7| 7| 7| 1| 7| 5| 1| 7|              |            |
                             DAY ON TEST   | 7| 3| 5| 3| 3| 3| 8| 3| 3| 5| 3| 5| 3| 3| 3| 6| 3| 5| 6| 3|              |            |
                                           | 8| 6| 8| 6| 0| 6| 4| 0| 0| 9| 4| 9| 7| 7| 7| 6| 0| 2| 5| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|              |      A     |
     100 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Nephropathy, Chronic                 |    1     2  2  1     1  1     1  1  2                                    |     29  1.3|
      Artery, Necrosis, Fibrinoid          |                                                    4                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +               |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 4| 7| 7| 1| 7| 7| 7| 1| 4| 7| 7| 7| 7| 6| 4| 1| 7| 7| 1| 1| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 5| 0| 3| 6| 3| 3| 3| 7| 5| 3| 3| 3| 3| 1| 3| 6| 3| 3| 3| 6| 3| 3|             
                                           | 1| 9| 1| 8| 9| 1| 6| 6| 1| 1| 9| 8| 1| 1| 1| 1| 0| 3| 6| 0| 2| 5| 5| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
     175 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                                              X                           |             
      Eosinophilic Focus                   |    X                                                     X               |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Chronic Active         |             3                                                            |             
      Necrosis, Coagulative                |             3                                                            |             
      Vacuolization Cytoplasmic            |          2                                                               |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                   +        +  +        +  +            |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Necrotizing            | 4                                   4        4           4  4            |             
      Mineralization                       |                                              1           1               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                          4               |             
      Acinus, Hyperplasia                  |                                                                          |             
      Duct, Ectasia                        |                                                          4               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                 2                        |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +|             
      Dentine, Incisor, Dysplasia          | 1  1                 1     1                 1              1        1   |             
      Dentine, Incisor, Necrosis           |                                                                          |             
      Incisor, Ameloblast, Atrophy         |                                                                          |             
      Peridontal Tissue, Incisor, Necrosis |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 4| 7| 7| 1| 7| 7| 7| 1| 4| 7| 7| 7| 7| 6| 4| 1| 7| 7| 1| 1| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 5| 0| 3| 6| 3| 3| 3| 7| 5| 3| 3| 3| 3| 1| 3| 6| 3| 3| 3| 6| 3| 3|             
                                           | 1| 9| 1| 8| 9| 1| 6| 6| 1| 1| 9| 8| 1| 1| 1| 1| 0| 3| 6| 0| 2| 5| 5| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
     175 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Cyst                                 |                                                                          |             
      Cytoplasmic Alteration               |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Capsule, Spindle Cell, Hyperplasia   |                                                             2            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M|             
      Cyst                                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                      2     2        2  3                 2              2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Ultimobranchial Cyst                 |                                                                      X   |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         | 2     2                             1     2  2           2  2           2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                      +                    +                              |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2     2     2  4     2  2  2        1  2  2  2  3        2  2        2  2|             
      Cyst                                 | X  X                                X           X  X        X            |             
      Necrosis, Coagulative                |                                                                          |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                2                                                         |             
      Dilatation                           |       4  4                                4        3                     |             
      Hyperplasia, Cystic, Glandular       | 2  2     2  2  2     4  3  4     2  2  3     1  2  4     2  3        2  3|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Myelofibrosis               |    2  1  1           1  1  1     1  1  2  1        2        2        1  1|             
      Humerus, Myelofibrosis               |          1           1  2  2           2  1  1     1        2        2  2|             
      Mandible, Myelofibrosis              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 4| 7| 7| 1| 7| 7| 7| 1| 4| 7| 7| 7| 7| 6| 4| 1| 7| 7| 1| 1| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 5| 0| 3| 6| 3| 3| 3| 7| 5| 3| 3| 3| 3| 1| 3| 6| 3| 3| 3| 6| 3| 3|             
                                           | 1| 9| 1| 8| 9| 1| 6| 6| 1| 1| 9| 8| 1| 1| 1| 1| 0| 3| 6| 0| 2| 5| 5| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
     175 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Maxilla, Myelofibrosis               |             1        1  1  1     1     2     1           2           2  2|             
      Thoracic, Vertebra, Myelofibrosis    |    1  3  2  2        3  3  3     2  4  3  2  2  1  1     3  3        3  3|             
      Tibia, Myelofibrosis                 |       2              1     2     1                                1  2  2|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2                    2                       2  4                        |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |             2                                                            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X  X                                   X                                 |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                3                                                         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +     +  +|             
      Femur, Osteosclerosis                |                                                                          |             
      Humerus, Osteosclerosis              |                1                                                         |             
      Intervertebral Disc, Degeneration    |                         1                    1                           |             
      Rib, Cartilage, Degeneration         |                                     3                                    |             
      Thoracic, Vertebra, Osteosclerosis   |                                           3                              |             
      Tibia, Osteosclerosis                |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                   +                                   +           +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      White Matter, Degeneration           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 4| 7| 7| 1| 7| 7| 7| 1| 4| 7| 7| 7| 7| 6| 4| 1| 7| 7| 1| 1| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 5| 0| 3| 6| 3| 3| 3| 7| 5| 3| 3| 3| 3| 1| 3| 6| 3| 3| 3| 6| 3| 3|             
                                           | 1| 9| 1| 8| 9| 1| 6| 6| 1| 1| 9| 8| 1| 1| 1| 1| 0| 3| 6| 0| 2| 5| 5| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
     175 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Suppurative                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                    I                     |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | M  +  M  +  +  +  +  M  +  +  +  M  I  +  M  M  M  +  +  M  M  M  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |                                                                          |             
      Cyst                                 |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       | 1           1              1              1              1           1  1|             
      Nephropathy, Chronic                 |                               1        2  1  2                       1   |             
      Perivascular, Hyperplasia, Lymphoid  |                                                                          |             
      Renal Tubule, Necrosis               |                                        2                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | M  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 5| 2| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 1| 6| 3| 3| 3| 3| 3| 3| 8| 4| 1| 8| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3|             
                                           | 0| 7| 2| 2| 5| 2| 2| 2| 0| 2| 2| 4| 1| 9| 8| 3| 0| 3| 3| 6| 3| 0| 3| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                               ANIMAL ID   | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|             
     175 PPM                               | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                                           X                              |             
      Eosinophilic Focus                   |                            X                                            X|             
      Hematopoietic Cell Proliferation     |          2                                                  2  2         |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Vacuolization Cytoplasmic            | 2                             2                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +     +  +        +  +     +  +  +  +           +        +      |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Necrotizing            |                4           4  4              4           4               |             
      Mineralization                       |                                              1                           |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                          3               |             
      Acinus, Hyperplasia                  |                      2                                         1         |             
      Duct, Ectasia                        |                                                          4               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                           2                              |             
      Inflammation, Chronic Active         |                                           2                              |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                          2               |             
      Mineralization                       |                   1        1  1                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dentine, Incisor, Dysplasia          |    2  1        2     1           1     2     1  1  1                     |             
      Dentine, Incisor, Necrosis           |    3                                                                     |             
      Incisor, Ameloblast, Atrophy         |    3                                   4                                 |             
      Peridontal Tissue, Incisor, Necrosis |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 5| 2| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 1| 6| 3| 3| 3| 3| 3| 3| 8| 4| 1| 8| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3|             
                                           | 0| 7| 2| 2| 5| 2| 2| 2| 0| 2| 2| 4| 1| 9| 8| 3| 0| 3| 3| 6| 3| 0| 3| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                               ANIMAL ID   | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|             
     175 PPM                               | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                X                                                         |             
      Cyst                                 |                                                                X         |             
      Cytoplasmic Alteration               |                               3                                          |             
      Hematopoietic Cell Proliferation     |          2                                                               |             
      Hyperplasia                          |                                                                          |             
      Capsule, Spindle Cell, Hyperplasia   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           | 2                    2  2  3                    3  3           2  2  1  2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Ultimobranchial Cyst                 | X                                                                    X   |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         | 2     1        1  1  1  1     3              1     2  2     2     1  2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2  4  3           2  3     2  2  3        3  2  2  2  2  3  2  1  2  4  2|             
      Cyst                                 |    X           X  X        X     X        X  X        X           X  X   |             
      Necrosis, Coagulative                |                                  4                                       |             
      Thrombosis                           |                                  X                                       |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Dilatation                           |    4     3        4                          4                           |             
      Hyperplasia, Cystic, Glandular       | 2     2  3     3  3  3  3  3  4  2  2     3  2  3  2  4  3  2  3  2  4  3|             
      Inflammation, Suppurative            |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Myelofibrosis               | 2  1  1              1  1  1  1              1  1  2  1  1  1  1  1     2|             
      Humerus, Myelofibrosis               | 2  3           2     2     2                 2  2     1  2  2  1  2     3|             
      Mandible, Myelofibrosis              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 5| 2| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 1| 6| 3| 3| 3| 3| 3| 3| 8| 4| 1| 8| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3|             
                                           | 0| 7| 2| 2| 5| 2| 2| 2| 0| 2| 2| 4| 1| 9| 8| 3| 0| 3| 3| 6| 3| 0| 3| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                               ANIMAL ID   | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|             
     175 PPM                               | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Maxilla, Myelofibrosis               | 2     2  1              1  2              2  1  2  2  3  1     1  2  1  1|             
      Thoracic, Vertebra, Myelofibrosis    | 2  2  2  2     3  2  3  2  4  2           2  3  2  2  3  2  3  3  3  2  4|             
      Tibia, Myelofibrosis                 | 2  2     2        1  1  1                 1  1     1           2  2  3   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                      3                                3                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |       3  4     3     2           4                                       |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                         2  2                 2  2     2        2         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                |                         2                             3                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |       2                                                              1   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |          4        4                                                      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Osteosclerosis                |                                        3                                 |             
      Humerus, Osteosclerosis              |                                        4                                 |             
      Intervertebral Disc, Degeneration    | 3  2                 3                             3           2  2      |             
      Rib, Cartilage, Degeneration         |                                                                          |             
      Thoracic, Vertebra, Osteosclerosis   |                                        4                                 |             
      Tibia, Osteosclerosis                |                                        4                             1   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |             +                                   +                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      White Matter, Degeneration           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                2         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 5| 2| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 1| 6| 3| 3| 3| 3| 3| 3| 8| 4| 1| 8| 3| 3| 3| 3| 6| 3| 3| 3| 3| 3|             
                                           | 0| 7| 2| 2| 5| 2| 2| 2| 0| 2| 2| 4| 1| 9| 8| 3| 0| 3| 3| 6| 3| 0| 3| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                               ANIMAL ID   | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|             
     175 PPM                               | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Suppurative                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | M  M  M  +  +  +  M  M  +  M  M  M  M  M  M  M  M  M  M  +  +  M  M  M  M|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |                                                                          |             
      Cyst                                 |                                                    X                     |             
      Metaplasia, Osseous                  |                                                                      1   |             
      Mineralization                       |                1     1  1     1              1  1        2  1           1|             
      Nephropathy, Chronic                 |    3                 1                             1           1        1|             
      Perivascular, Hyperplasia, Lymphoid  |                                              2                           |             
      Renal Tubule, Necrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 4| 4| 5| 7| 7| 7| 3| 7| 7| 7| 4| 7| 4| 7| 6| 7| 7| 6| 5| 4| 7| 4| 1|             
                             DAY ON TEST   | 6| 3| 5| 7| 0| 3| 3| 3| 6| 3| 3| 3| 5| 3| 5| 3| 0| 3| 3| 8| 7| 5| 3| 5| 6|             
                                           | 6| 2| 9| 7| 0| 0| 3| 3| 1| 6| 6| 6| 9| 0| 8| 6| 6| 6| 6| 4| 3| 9| 6| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
     175 PPM                               | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                 4                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                            X                                             |             
      Eosinophilic Focus                   |          X                    X  X                                X      |             
      Hematopoietic Cell Proliferation     |                   2              2                                       |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Chronic Active         |                               2                                          |             
      Necrosis, Coagulative                |                                                          4               |             
      Vacuolization Cytoplasmic            |                               2                                1     1   |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +     +        +  +                    +           +            |             
      Inflammation, Chronic Active         |                                                 2                        |             
      Inflammation, Necrotizing            |          4     4           4                                             |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                          |             
      Acinus, Hyperplasia                  |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                      2                                                   |             
      Inflammation, Chronic Active         |          4           2                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                 3                        |             
      Mineralization                       |                   1                                                      |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Dentine, Incisor, Dysplasia          |                   3  1     1                       1  1                  |             
      Dentine, Incisor, Necrosis           |                   3                                                      |             
      Incisor, Ameloblast, Atrophy         |                   3                                                      |             
      Peridontal Tissue, Incisor, Necrosis |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 4| 4| 5| 7| 7| 7| 3| 7| 7| 7| 4| 7| 4| 7| 6| 7| 7| 6| 5| 4| 7| 4| 1|             
                             DAY ON TEST   | 6| 3| 5| 7| 0| 3| 3| 3| 6| 3| 3| 3| 5| 3| 5| 3| 0| 3| 3| 8| 7| 5| 3| 5| 6|             
                                           | 6| 2| 9| 7| 0| 0| 3| 3| 1| 6| 6| 6| 9| 0| 8| 6| 6| 6| 6| 4| 3| 9| 6| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
     175 PPM                               | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Cyst                                 |                                                                          |             
      Cytoplasmic Alteration               |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                 2                        |             
      Hyperplasia                          |                                  2                                       |             
      Capsule, Spindle Cell, Hyperplasia   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  M  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                        X                                 |             
      Pars Distalis, Hyperplasia           |                                        2     2     2  2                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                               2                                          |             
      Ultimobranchial Cyst                 |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                   1        1  2  2                 2              1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                        +                                 |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    3           2  1  2     2  3  1     2     1  3  1  2           2      |             
      Cyst                                 | X              X     X              X                                    |             
      Necrosis, Coagulative                |                                                                          |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Dilatation                           |    4                    3                                                |             
      Hyperplasia, Cystic, Glandular       | 4  2  2     2  2  2  2  1  2  2  3  3  4  2  2  2  2  2  2  3  3  2  2   |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Myelofibrosis               |       1        1           1  1  2  2  2  1  1     2              1  1   |             
      Humerus, Myelofibrosis               |       1     2  1     2     1     1        2        2     3           1  1|             
      Mandible, Myelofibrosis              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 4| 4| 5| 7| 7| 7| 3| 7| 7| 7| 4| 7| 4| 7| 6| 7| 7| 6| 5| 4| 7| 4| 1|             
                             DAY ON TEST   | 6| 3| 5| 7| 0| 3| 3| 3| 6| 3| 3| 3| 5| 3| 5| 3| 0| 3| 3| 8| 7| 5| 3| 5| 6|             
                                           | 6| 2| 9| 7| 0| 0| 3| 3| 1| 6| 6| 6| 9| 0| 8| 6| 6| 6| 6| 4| 3| 9| 6| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
     175 PPM                               | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Maxilla, Myelofibrosis               |                   2  2     1  1  1     1           2  1           1  2   |             
      Thoracic, Vertebra, Myelofibrosis    | 2     2     2  3  2  2     2  2  3  2  2  1  3     4  2  2  1  1  2  1   |             
      Tibia, Myelofibrosis                 | 1     1                                      1     1  2                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 3  4     2                    3        3        4     3                  |             
      Hemorrhage                           |                                                 4                        |             
      Hyperplasia, Lymphoid                |                   2              3                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Cyst                                 |                                     X              X  X                  |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                        1              3           1      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Femur, Osteosclerosis                |                                                                          |             
      Humerus, Osteosclerosis              |                                                                          |             
      Intervertebral Disc, Degeneration    |                3                 2     3     2  2                 2      |             
      Rib, Cartilage, Degeneration         |                                                                          |             
      Thoracic, Vertebra, Osteosclerosis   |                                                                          |             
      Tibia, Osteosclerosis                |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      White Matter, Degeneration           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                     2        2                           |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 4| 4| 5| 7| 7| 7| 3| 7| 7| 7| 4| 7| 4| 7| 6| 7| 7| 6| 5| 4| 7| 4| 1|             
                             DAY ON TEST   | 6| 3| 5| 7| 0| 3| 3| 3| 6| 3| 3| 3| 5| 3| 5| 3| 0| 3| 3| 8| 7| 5| 3| 5| 6|             
                                           | 6| 2| 9| 7| 0| 0| 3| 3| 1| 6| 6| 6| 9| 0| 8| 6| 6| 6| 6| 4| 3| 9| 6| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5|             
     175 PPM                               | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Suppurative                     |                                                 2                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | M  +  +  +  +  M  M  +  +  M  M  M  +  +  +  +  M  M  M  M  M  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular                      |    X                                                                     |             
      Cyst                                 |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       | 1              1     1     1  1                             1            |             
      Nephropathy, Chronic                 |    1     1        1  2        1        2     1  2  1           1  1      |             
      Perivascular, Hyperplasia, Lymphoid  |                                                                          |             
      Renal Tubule, Necrosis               |                                                    2                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 2| 2| 5| 7| 7| 1| 7| 7| 5| 7| 1| 1| 3| 7| 3| 7| 7| 7| 1| 7| 7| 1|  |            |
                             DAY ON TEST   | 5| 3| 7| 8| 6| 3| 3| 6| 3| 3| 7| 0| 6| 6| 4| 3| 1| 3| 3| 1| 6| 3| 3| 6|  |            |
                                           | 8| 6| 8| 6| 8| 7| 7| 5| 7| 1| 9| 5| 5| 6| 9| 7| 4| 7| 7| 5| 6| 7| 0| 6|  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   B6C3F1 MICE FEMALE                      | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|  |      T     |
                               ANIMAL ID   | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|  |      A     |
     175 PPM                               | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|  |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|  |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  98        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  98        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  97        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  98        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  98        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  98        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  98        |
      Inflammation, Chronic Active         |                               2                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  97        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  97        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
      Clear Cell Focus                     |                                                                          |      3     |
      Eosinophilic Focus                   | X           X                                                  X  X      |     12     |
      Hematopoietic Cell Proliferation     |                                                       2                  |      6  2.0|
      Hepatodiaphragmatic Nodule           |    X                                                                     |      1     |
      Inflammation, Chronic Active         |                                  3                                       |      3  2.7|
      Necrosis, Coagulative                |                                  3                                       |      3  3.3|
      Vacuolization Cytoplasmic            |                                                                          |      6  1.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                                         +        +  +        +      |  28        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Inflammation, Necrotizing            |                                              4        4                  |     15  4.0|
      Mineralization                       |                                              1                           |      4  1.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  98        |
      Acinus, Atrophy                      |                                                                          |      2  3.5|
      Acinus, Hyperplasia                  |                                                                          |      2  1.5|
      Duct, Ectasia                        |             2                                                            |      3  3.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
      Duct, Ectasia                        |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  98        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  98        |
      Acanthosis                           |                               2                                          |      3  2.0|
      Inflammation, Chronic Active         |             3                 2                                          |      5  2.6|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  98        |
      Erosion                              |                                                                          |      3  2.3|
      Mineralization                       |                                                                          |      4  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +     +  +  +  +        +  +  +  +  +  +     +  +      |  89        |
      Dentine, Incisor, Dysplasia          |                   1     1                                         1      |     24  1.2|
      Dentine, Incisor, Necrosis           |                                                                          |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 2| 2| 5| 7| 7| 1| 7| 7| 5| 7| 1| 1| 3| 7| 3| 7| 7| 7| 1| 7| 7| 1|  |            |
                             DAY ON TEST   | 5| 3| 7| 8| 6| 3| 3| 6| 3| 3| 7| 0| 6| 6| 4| 3| 1| 3| 3| 1| 6| 3| 3| 6|  |            |
                                           | 8| 6| 8| 6| 8| 7| 7| 5| 7| 1| 9| 5| 5| 6| 9| 7| 4| 7| 7| 5| 6| 7| 0| 6|  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   B6C3F1 MICE FEMALE                      | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|  |      T     |
                               ANIMAL ID   | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|  |      A     |
     175 PPM                               | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|  |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|  |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Incisor, Ameloblast, Atrophy         |                                                                          |      3  3.3|
      Peridontal Tissue, Incisor, Necrosis |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1     |
      Cyst                                 |                                                                          |      1     |
      Cytoplasmic Alteration               |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
      Hyperplasia                          |                1                                                         |      2  1.5|
      Capsule, Spindle Cell, Hyperplasia   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  98        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  92        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  97        |
      Pars Distalis, Cyst                  |                   X                                                      |      2     |
      Pars Distalis, Hyperplasia           |    2           2  2     2                                         3      |     25  2.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
      Inflammation, Chronic Active         |                                                          2               |      2  2.0|
      Ultimobranchial Cyst                 |                                                                          |      3     |
      Follicle, Cyst                       |                X                                                         |      1     |
      Follicular Cell, Hyperplasia         |    2           2  2     2                             1        1         |     33  1.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                          M               |   3        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  98        |
      Atrophy                              |    2           2  2     2  3     4           2     2  1        2  3      |     59  2.2|
      Cyst                                 |                   X        X     X           X        X                  |     25     |
      Necrosis, Coagulative                |                                                                          |      1  4.0|
      Thrombosis                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 2| 2| 5| 7| 7| 1| 7| 7| 5| 7| 1| 1| 3| 7| 3| 7| 7| 7| 1| 7| 7| 1|  |            |
                             DAY ON TEST   | 5| 3| 7| 8| 6| 3| 3| 6| 3| 3| 7| 0| 6| 6| 4| 3| 1| 3| 3| 1| 6| 3| 3| 6|  |            |
                                           | 8| 6| 8| 6| 8| 7| 7| 5| 7| 1| 9| 5| 5| 6| 9| 7| 4| 7| 7| 5| 6| 7| 0| 6|  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   B6C3F1 MICE FEMALE                      | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|  |      T     |
                               ANIMAL ID   | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|  |      A     |
     175 PPM                               | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|  |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|  |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Angiectasis                          |                                                                          |      1  2.0|
      Dilatation                           |    4           4              3                                3         |     14  3.6|
      Hyperplasia, Cystic, Glandular       | 2     2  2  2  3  3     1  2  3  2        1  3  3  3  3  2     2  2      |     81  2.5|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
      Femoral, Myelofibrosis               | 1              1  1     1     1              1     1  1  1     1  1      |     53  1.2|
      Humerus, Myelofibrosis               | 1  2           2  1           1     1     4  2     1  2        2  1      |     47  1.7|
      Mandible, Myelofibrosis              |                                           4                              |      1  4.0|
      Maxilla, Myelofibrosis               |             3  2  1                       4  2     1     1     2  1      |     44  1.6|
      Thoracic, Vertebra, Myelofibrosis    | 2  2        1  3  3     3  2  2           3  2     2  2  3     2  2      |     74  2.3|
      Tibia, Myelofibrosis                 |    2                                      3                              |     26  1.6|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  98        |
      Hyperplasia, Lymphoid                |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  94        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
      Hematopoietic Cell Proliferation     |                   3              3           3     3                     |     20  3.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                2                                                  2      |     11  2.1|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  92        |
      Cyst                                 |                                                                          |      6     |
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
      Hyperplasia, Cystic                  |    1                                                                     |      7  1.7|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
      Inflammation, Chronic Active         |                                                                          |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +     +  +  +  +        +  +  +  +  +  +     +  +      |  89        |
      Femur, Osteosclerosis                |                                                                          |      1  3.0|
      Humerus, Osteosclerosis              |                                                                          |      2  2.5|
      Intervertebral Disc, Degeneration    |                                                          2        2      |     16  2.2|
      Rib, Cartilage, Degeneration         |                                                                          |      1  3.0|
      Thoracic, Vertebra, Osteosclerosis   |                                                                   3      |      3  3.3|
      Tibia, Osteosclerosis                |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 2| 2| 5| 7| 7| 1| 7| 7| 5| 7| 1| 1| 3| 7| 3| 7| 7| 7| 1| 7| 7| 1|  |            |
                             DAY ON TEST   | 5| 3| 7| 8| 6| 3| 3| 6| 3| 3| 7| 0| 6| 6| 4| 3| 1| 3| 3| 1| 6| 3| 3| 6|  |            |
                                           | 8| 6| 8| 6| 8| 7| 7| 5| 7| 1| 9| 5| 5| 6| 9| 7| 4| 7| 7| 5| 6| 7| 0| 6|  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   B6C3F1 MICE FEMALE                      | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|  |      T     |
                               ANIMAL ID   | 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|  |      A     |
     175 PPM                               | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|  |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|  |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                      +              +  +                    +        +   |  11        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
      Compression                          |                            X                                             |      1     |
      Inflammation, Chronic Active         |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |       +                                                                  |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |       +                                                                  |   1        |
      White Matter, Degeneration           |       2                                                                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
      Inflammation, Chronic Active         |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |             +                                                            |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                        +                                 |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  M  +  +  +  +  M  +   |  52        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
      Atypia Cellular                      |                                                                          |      1     |
      Cyst                                 |                                                                          |      1     |
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Mineralization                       |                1              1              1  1     1        1         |     28  1.0|
      Nephropathy, Chronic                 |    2           1                          3           1           1      |     26  1.4|
      Perivascular, Hyperplasia, Lymphoid  |                                                    2                     |      2  2.0|
      Renal Tubule, Necrosis               |                2                                                         |      3  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  97        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 6| 1| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 1| 6| 7| 6| 7| 1| 7|             
                             DAY ON TEST   | 5| 9| 4| 6| 3| 3| 3| 2| 3| 3| 4| 3| 3| 5| 3| 3| 3| 3| 6| 6| 3| 2| 2| 6| 3|             
                                           | 8| 6| 5| 5| 0| 0| 0| 9| 0| 0| 1| 0| 0| 9| 0| 1| 1| 1| 5| 2| 1| 6| 1| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     0 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                   X                                                      |             
      Clear Cell Focus                     | X           X     X     X                          X        X            |             
      Cytologic Alterations                |                                                                          |             
      Eosinophilic Focus                   | X           X                             X                              |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |                                     2                                    |             
      Necrosis, Coagulative                |                                     1                                    |             
      Vacuolization Cytoplasmic            | 2                 2              1     3  1                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                       +                                   +         |             
      Inflammation, Necrotizing            |    4                                                           4         |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      |                                                    1                     |             
      Acinus, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                               2                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Dentine, Incisor, Dysplasia          | 2                 2  4  3  3  3  2  3     4  3  4  3     4  2  3  3  1  2|             
      Dentine, Incisor, Necrosis           |                            3     2                                       |             
      Incisor, Lower, Dysplasia            |                                                                          |             
      Incisor, Ameloblast, Atrophy         |                      4  4     3     3     4  3  4  3     4     3  4      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Mesenteric Artery, Inflammation,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 6| 1| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 1| 6| 7| 6| 7| 1| 7|             
                             DAY ON TEST   | 5| 9| 4| 6| 3| 3| 3| 2| 3| 3| 4| 3| 3| 5| 3| 3| 3| 3| 6| 6| 3| 2| 2| 6| 3|             
                                           | 8| 6| 5| 5| 0| 0| 0| 9| 0| 0| 1| 0| 0| 9| 0| 1| 1| 1| 5| 2| 1| 6| 1| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     0 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
           Chronic Active                  |                                                                          |             
      Mesenteric Artery, Necrosis,         |                                                                          |             
          Fibrinoid                        |                                                                          |             
      Renal Artery, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                   X                                                      |             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |             2     1                                      2     1        1|             
      Bilateral, Capsule, Spindle Cell,    |                                                                          |             
           Hyperplasia                     |                                                                          |             
      Capsule, Spindle Cell, Hyperplasia   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +     +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2                                   2  2                           |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +|             
      Cyst                                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  I  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Follicular Cell, Hyperplasia         |                2           2                                             |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aspermia                             |                                                                          |             
      Granuloma Sperm                      |                         4                                                |             
      Inflammation, Chronic Active         |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +        +     +  +  +  +  +  +  +  +  +  +  +     +  +  +        +|             
      Atrophy                              |       4        4     4  3  4  4  3  3     3  2  3  3        3  4        3|             
      Inflammation, Chronic Active         |       3        2     2  2     3     4           2              2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 6| 1| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 1| 6| 7| 6| 7| 1| 7|             
                             DAY ON TEST   | 5| 9| 4| 6| 3| 3| 3| 2| 3| 3| 4| 3| 3| 5| 3| 3| 3| 3| 6| 6| 3| 2| 2| 6| 3|             
                                           | 8| 6| 5| 5| 0| 0| 0| 9| 0| 0| 1| 0| 0| 9| 0| 1| 1| 1| 5| 2| 1| 6| 1| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     0 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Duct, Dilatation                     |       3        4     3  3  4  4  4  3  4  3     2        4  4  3        4|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                   4      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                          +               |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Myelofibrosis               |                                                                          |             
      Maxilla, Myelofibrosis               |    1                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    4  2                                                                  |             
      Hyperplasia, Lymphoid                |                         3                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  M  M  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Cyst                                 |    X                                                                    X|             
      Inflammation, Chronic Active         |                               4                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Inflammation, Chronic Active         |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +|             
      Intervertebral Disc, Degeneration    |                                           3        2                     |             
      Thoracic, Vertebra, Osteosclerosis   |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +                                            +              +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Leukocytosis                         |                               X                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     | 2                                                                        |             
      Mediastinum, Mineralization          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 6| 1| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 1| 6| 7| 6| 7| 1| 7|             
                             DAY ON TEST   | 5| 9| 4| 6| 3| 3| 3| 2| 3| 3| 4| 3| 3| 5| 3| 3| 3| 3| 6| 6| 3| 2| 2| 6| 3|             
                                           | 8| 6| 5| 5| 0| 0| 0| 9| 0| 0| 1| 0| 0| 9| 0| 1| 1| 1| 5| 2| 1| 6| 1| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
     0 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                2                                                         |             
      Nasolacrimal Duct, Hyperplasia,      |                                                                          |             
          Squamous                         |                                                                         2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                               2     2                                    |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                         +|             
      Phthisis Bulbi                       |                                                                         X|             
      Cornea, Inflammation, Chronic Active |                                                                          |             
      Cornea, Mineralization               |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  M  +  +  M  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                X        X        X              X                        |             
      Inflammation, Chronic Active         |                                                                   2      |             
      Mineralization                       |    1        1  2  1  1  1  1  1  1  1     1  1  1  1     1  1  1        1|             
      Necrosis, Coagulative                |                4                                                         |             
      Nephropathy, Chronic                 | 2           2  1  1  1  2  1  1  2  2  2  2  2  2  2     1  2     1     1|             
      Artery, Necrosis, Fibrinoid          |                2                                                         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 1| 7| 7| 6| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 5| 2| 2| 3| 9| 3| 3| 3| 3| 3| 2| 2| 2| 7| 2| 6| 3| 3| 8| 3| 3| 3| 2| 6|             
                                           | 1| 9| 9| 9| 1| 1| 1| 2| 2| 2| 2| 9| 0| 9| 1| 1| 5| 2| 2| 4| 2| 2| 3| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
     0 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                        X     X     X                     |             
      Clear Cell Focus                     |    X        X        X     X        X              X        X     X      |             
      Cytologic Alterations                |                                                                          |             
      Eosinophilic Focus                   |                               X                                      X   |             
      Hyperplasia                          |                                              2                           |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis, Coagulative                |                                                                         4|             
      Vacuolization Cytoplasmic            |    2        2                                      2           1  2      |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                         +                           |             
      Inflammation, Necrotizing            |    4                                                                     |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    2                                                                     |             
      Acinus, Atrophy                      |    3                                                                     |             
      Acinus, Inflammation, Chronic Active |                2                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Chronic Active         |                                                                         3|             
      Mineralization                       |                      1              2                                    |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Dentine, Incisor, Dysplasia          | 4  3  1  4  3  1  4  2  2  1  4  3  3  1  1        2  4     3  1  3  3  4|             
      Dentine, Incisor, Necrosis           |                                                                          |             
      Incisor, Lower, Dysplasia            | 3        4                    4     3                                3   |             
      Incisor, Ameloblast, Atrophy         | 4        4  3     4           4  4  3  4              4     3     3  3  4|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                     +  +                                 |             
      Mesenteric Artery, Inflammation,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 1| 7| 7| 6| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 5| 2| 2| 3| 9| 3| 3| 3| 3| 3| 2| 2| 2| 7| 2| 6| 3| 3| 8| 3| 3| 3| 2| 6|             
                                           | 1| 9| 9| 9| 1| 1| 1| 2| 2| 2| 2| 9| 0| 9| 1| 1| 5| 2| 2| 4| 2| 2| 3| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
     0 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
           Chronic Active                  |                                        3                                 |             
      Mesenteric Artery, Necrosis,         |                                                                          |             
          Fibrinoid                        |                                        3                                 |             
      Renal Artery, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              |       1                                                                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                              X                           |             
      Cyst                                 |                            X                                             |             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          | 1        1  2     2  2  2                          2  1     1  2  2      |             
      Bilateral, Capsule, Spindle Cell,    |                                                                          |             
           Hyperplasia                     |                                                                          |             
      Capsule, Spindle Cell, Hyperplasia   |       2           4        4                       3                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               2  3     2                    2           2|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  M  +  M  +  +  +  +  +  +  +  +  M  +  M|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  I  M  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                                  2                                       |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X                                                                        |             
      Inflammation, Chronic Active         |          1                                                               |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aspermia                             |                                                                          |             
      Granuloma Sperm                      |          3                                                               |             
      Inflammation, Chronic Active         |                                                                          |             
      Duct, Dilatation                     |                   2                                                      |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +  +  +  +  +  +        +        +     +     +  +  +  +  +  +  +   |             
      Atrophy                              | 3     3  3  3  4  3  2        3        4     4     3  4  4  2  3  2  3   |             
      Inflammation, Chronic Active         | 2        2                                         4  2  4           4   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 1| 7| 7| 6| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 5| 2| 2| 3| 9| 3| 3| 3| 3| 3| 2| 2| 2| 7| 2| 6| 3| 3| 8| 3| 3| 3| 2| 6|             
                                           | 1| 9| 9| 9| 1| 1| 1| 2| 2| 2| 2| 9| 0| 9| 1| 1| 5| 2| 2| 4| 2| 2| 3| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
     0 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Duct, Dilatation                     | 4     4  2  3  3  3  4        4        3     3     3  4     3  3  2  2   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                    3                     |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                              +                           |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Myelofibrosis               |                                                                          |             
      Maxilla, Myelofibrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                          3               |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                   X        X                                             |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M  M  M  +  M  M  +  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Intervertebral Disc, Degeneration    |                                  3                                       |             
      Thoracic, Vertebra, Osteosclerosis   |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                              +  +                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                            2                                             |             
      Leukocytosis                         |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |             2                                                            |             
      Mediastinum, Mineralization          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 1| 7| 7| 6| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 5| 2| 2| 3| 9| 3| 3| 3| 3| 3| 2| 2| 2| 7| 2| 6| 3| 3| 8| 3| 3| 3| 2| 6|             
                                           | 1| 9| 9| 9| 1| 1| 1| 2| 2| 2| 2| 9| 0| 9| 1| 1| 5| 2| 2| 4| 2| 2| 3| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
     0 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Nasolacrimal Duct, Hyperplasia,      |                                                                          |             
          Squamous                         |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                              2           3               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Phthisis Bulbi                       |                                                                          |             
      Cornea, Inflammation, Chronic Active |                                                                          |             
      Cornea, Mineralization               |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | M  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  M  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          X  X        X     X        X                                   X|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       | 1     1  1  1  1  1  1  1  1  1  1  2  1  1  1     1  1     1  1  1  1  1|             
      Necrosis, Coagulative                |                                                                          |             
      Nephropathy, Chronic                 | 2  2  2  1  1     2  2  1  2  2  2  2  2           2  1  2  1  2  2  2   |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 6| 7| 4| 7| 1| 7| 7| 7| 7| 7| 1| 4| 5| 6| 7| 7| 7| 7| 4| 7| 6|             
                             DAY ON TEST   | 3| 3| 6| 3| 9| 3| 5| 3| 6| 0| 2| 3| 3| 3| 6| 2| 7| 9| 3| 3| 3| 3| 5| 3| 9|             
                                           | 3| 3| 6| 3| 1| 3| 8| 3| 6| 4| 9| 3| 3| 6| 5| 0| 8| 8| 6| 6| 6| 6| 8| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|             
     0 PPM                                 | 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                         X|             
      Clear Cell Focus                     | X        X     X     X        X     X  X        X        X  X  X  X      |             
      Cytologic Alterations                |                                                                          |             
      Eosinophilic Focus                   | X                 X                                            X         |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |                                                       2                  |             
      Necrosis, Coagulative                |                                                                          |             
      Vacuolization Cytoplasmic            |                      2        2     2        2           2        3      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                         +            |             
      Inflammation, Necrotizing            |                   3                                         4            |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
      Acinus, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +     +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Dentine, Incisor, Dysplasia          | 1           4  1  2  2     4  2  2  3  2     2  3  4  2     3  4  2  4   |             
      Dentine, Incisor, Necrosis           |                                                                          |             
      Incisor, Lower, Dysplasia            |                                                                      3   |             
      Incisor, Ameloblast, Atrophy         |             4              4        3  1     3  4  4        3  4     4   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Mesenteric Artery, Inflammation,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 6| 7| 4| 7| 1| 7| 7| 7| 7| 7| 1| 4| 5| 6| 7| 7| 7| 7| 4| 7| 6|             
                             DAY ON TEST   | 3| 3| 6| 3| 9| 3| 5| 3| 6| 0| 2| 3| 3| 3| 6| 2| 7| 9| 3| 3| 3| 3| 5| 3| 9|             
                                           | 3| 3| 6| 3| 1| 3| 8| 3| 6| 4| 9| 3| 3| 6| 5| 0| 8| 8| 6| 6| 6| 6| 8| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|             
     0 PPM                                 | 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
           Chronic Active                  |                                                                          |             
      Mesenteric Artery, Necrosis,         |                                                                          |             
          Fibrinoid                        |                                                                          |             
      Renal Artery, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Cyst                                 |                            X                                             |             
      Hyperplasia                          |                                                          2               |             
      Hypertrophy                          | 2        2     2     1           2  1  2              2  2  2           1|             
      Bilateral, Capsule, Spindle Cell,    |                                                                          |             
           Hyperplasia                     |                   3                                                      |             
      Capsule, Spindle Cell, Hyperplasia   |                      3           3  3                    4               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            3                    2  2                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                       X                  |             
      Pars Distalis, Hyperplasia           |                               3        1                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Follicular Cell, Hyperplasia         |                      1                 2              2                 2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aspermia                             |                            X                                             |             
      Granuloma Sperm                      |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +           +  +           +     +  +  +              +  +  +  +  +  +  +|             
      Atrophy                              | 3           4              4     4  3  3                 3     2     3   |             
      Inflammation, Chronic Active         |             4  4                                      2              4   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 6| 7| 4| 7| 1| 7| 7| 7| 7| 7| 1| 4| 5| 6| 7| 7| 7| 7| 4| 7| 6|             
                             DAY ON TEST   | 3| 3| 6| 3| 9| 3| 5| 3| 6| 0| 2| 3| 3| 3| 6| 2| 7| 9| 3| 3| 3| 3| 5| 3| 9|             
                                           | 3| 3| 6| 3| 1| 3| 8| 3| 6| 4| 9| 3| 3| 6| 5| 0| 8| 8| 6| 6| 6| 6| 8| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|             
     0 PPM                                 | 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Duct, Dilatation                     | 4           3  4           3     3  4  4              3  4     3  4     3|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                            2                                             |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                            3                                             |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Myelofibrosis               |                                                    1                     |             
      Maxilla, Myelofibrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                            3                                            2|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M|             
      Cyst                                 |                               X     X                             X      |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  +  M  +  M  +  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                         4|             
      Inflammation, Chronic Active         |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Intervertebral Disc, Degeneration    |                                                    3                     |             
      Thoracic, Vertebra, Osteosclerosis   |          3                             3                                 |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |       +                 +                 +                              |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                      2                                                   |             
      Leukocytosis                         |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                          2               |             
      Mediastinum, Mineralization          |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 6| 7| 4| 7| 1| 7| 7| 7| 7| 7| 1| 4| 5| 6| 7| 7| 7| 7| 4| 7| 6|             
                             DAY ON TEST   | 3| 3| 6| 3| 9| 3| 5| 3| 6| 0| 2| 3| 3| 3| 6| 2| 7| 9| 3| 3| 3| 3| 5| 3| 9|             
                                           | 3| 3| 6| 3| 1| 3| 8| 3| 6| 4| 9| 3| 3| 6| 5| 0| 8| 8| 6| 6| 6| 6| 8| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|             
     0 PPM                                 | 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Nasolacrimal Duct, Hyperplasia,      |                                                                          |             
          Squamous                         |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |             2                                                            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                      +                                                   |             
                                            __________________________________________________________________________|             
   Eye                                     |                                           +        +                     |             
      Phthisis Bulbi                       |                                                                          |             
      Cornea, Inflammation, Chronic Active |                                                    3                     |             
      Cornea, Mineralization               |                                           3                              |             
      Lens, Cataract                       |                                           4                              |             
      Retina, Atrophy                      |                                           4                              |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                            X  X        X           X        X        X   |             
      Inflammation, Chronic Active         |                                                       4                  |             
      Mineralization                       | 1  1     1  1  1     1     1  1  1  1  1        1  2  1  1  1  1     1  1|             
      Necrosis, Coagulative                |                                                                          |             
      Nephropathy, Chronic                 | 2  2     2     2  2  2     2  2  2  2  2           3  1  2  2  2  2  1   |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 1| 7| 7| 7| 7| 7| 6| 4| 4| 7| 7| 4| 7| 7| 7| 1| 7| 4| 7| 7| 1| 4|  |            |
                             DAY ON TEST   | 3| 3| 6| 3| 1| 2| 3| 2| 2| 5| 5| 2| 3| 5| 3| 3| 0| 6| 3| 5| 3| 3| 6| 5|  |            |
                                           | 6| 6| 6| 7| 5| 9| 7| 9| 5| 9| 8| 9| 7| 9| 7| 7| 1| 6| 0| 8| 7| 7| 5| 8|  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|  |      T     |
                               ANIMAL ID   | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|  |      A     |
     0 PPM                                 | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|  |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|  |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +   |  96        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  98        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  98        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
      Basophilic Focus                     |                   X  X  X                 X                              |      9     |
      Clear Cell Focus                     | X        X        X     X     X  X           X           X     X     X   |     36     |
      Cytologic Alterations                |                         X                                                |      1     |
      Eosinophilic Focus                   |          X                                                               |      9     |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
      Necrosis, Coagulative                |                               2                       4                  |      4  2.8|
      Vacuolization Cytoplasmic            |                   2     2  2           2     2           3     2     3   |     24  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +     +                          +                              |  10        |
      Inflammation, Necrotizing            |          4     4                          4                              |      8  3.9|
      Mineralization                       |                4                                                         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  98        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Acinus, Atrophy                      |                                                                      2   |      3  2.0|
      Acinus, Inflammation, Chronic Active |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  98        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
      Acanthosis                           |                                           3  2                           |      2  2.5|
      Inflammation, Chronic Active         |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
      Erosion                              |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +   |  90        |
      Dentine, Incisor, Dysplasia          | 3        3     3     3  2  1              1  1        4  2     3         |     69  2.6|
      Dentine, Incisor, Necrosis           |                                                                          |      2  2.5|
      Incisor, Lower, Dysplasia            |          4                          2                                    |      8  3.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  79                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 1| 7| 7| 7| 7| 7| 6| 4| 4| 7| 7| 4| 7| 7| 7| 1| 7| 4| 7| 7| 1| 4|  |            |
                             DAY ON TEST   | 3| 3| 6| 3| 1| 2| 3| 2| 2| 5| 5| 2| 3| 5| 3| 3| 0| 6| 3| 5| 3| 3| 6| 5|  |            |
                                           | 6| 6| 6| 7| 5| 9| 7| 9| 5| 9| 8| 9| 7| 9| 7| 7| 1| 6| 0| 8| 7| 7| 5| 8|  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|  |      T     |
                               ANIMAL ID   | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|  |      A     |
     0 PPM                                 | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|  |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|  |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Incisor, Ameloblast, Atrophy         | 3        3     3     3  2                 2           4        3         |     42  3.4|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                           +                              |   3        |
      Mesenteric Artery, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                          |      1  3.0|
      Mesenteric Artery, Necrosis,         |                                                                          |            |
          Fibrinoid                        |                                                                          |      1  3.0|
      Renal Artery, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
      Cardiomyopathy, Chronic              |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      2     |
      Cyst                                 |                                                                          |      2     |
      Hyperplasia                          |                                  2                          1            |      3  1.7|
      Hypertrophy                          | 2        1  2     2                          2              1  2         |     34  1.6|
      Bilateral, Capsule, Spindle Cell,    |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  3.0|
      Capsule, Spindle Cell, Hyperplasia   |                4                          3           4                  |     11  3.4|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  96        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  98        |
      Hyperplasia                          |                      2                                3                  |     13  2.2|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +   |  88        |
      Cyst                                 |          X                                                               |      2     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  91        |
      Pars Distalis, Cyst                  |                                           X                              |      2     |
      Pars Distalis, Hyperplasia           |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
      Cyst                                 |                                                                          |      1     |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Follicular Cell, Hyperplasia         |                                                                          |      6  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  80                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 1| 7| 7| 7| 7| 7| 6| 4| 4| 7| 7| 4| 7| 7| 7| 1| 7| 4| 7| 7| 1| 4|  |            |
                             DAY ON TEST   | 3| 3| 6| 3| 1| 2| 3| 2| 2| 5| 5| 2| 3| 5| 3| 3| 0| 6| 3| 5| 3| 3| 6| 5|  |            |
                                           | 6| 6| 6| 7| 5| 9| 7| 9| 5| 9| 8| 9| 7| 9| 7| 7| 1| 6| 0| 8| 7| 7| 5| 8|  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|  |      T     |
                               ANIMAL ID   | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|  |      A     |
     0 PPM                                 | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|  |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|  |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
      Aspermia                             |                                                                          |      1     |
      Granuloma Sperm                      |                                                                          |      2  3.5|
      Inflammation, Chronic Active         |             3                                                  3         |      2  3.0|
      Duct, Dilatation                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                             +            |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |             +  +     +           +  +     +  +  +              +         |  57        |
      Atrophy                              |             4        3           3  3     3  3  4                        |     48  3.2|
      Inflammation, Chronic Active         |                4                 3              2              3         |     22  2.9|
      Duct, Dilatation                     |             3        4           3  2     3  4  4              2         |     51  3.3|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
      Inflammation, Chronic Active         |                                                       3                  |      3  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  98        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
      Femoral, Myelofibrosis               |                                                                          |      1  1.0|
      Maxilla, Myelofibrosis               |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  98        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  94        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
      Hematopoietic Cell Proliferation     |    3                                            2           2            |      8  2.6|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +   |  87        |
      Cyst                                 | X                       X        X        X                              |     11     |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  M  M  M  +  +  M  M  +  M  M  M  +  M  M  M  M  M  M  M  M  M  M   |  14        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
      Autolysis                            |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  81                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 1| 7| 7| 7| 7| 7| 6| 4| 4| 7| 7| 4| 7| 7| 7| 1| 7| 4| 7| 7| 1| 4|  |            |
                             DAY ON TEST   | 3| 3| 6| 3| 1| 2| 3| 2| 2| 5| 5| 2| 3| 5| 3| 3| 0| 6| 3| 5| 3| 3| 6| 5|  |            |
                                           | 6| 6| 6| 7| 5| 9| 7| 9| 5| 9| 8| 9| 7| 9| 7| 7| 1| 6| 0| 8| 7| 7| 5| 8|  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|  |      T     |
                               ANIMAL ID   | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|  |      A     |
     0 PPM                                 | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|  |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|  |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +   |  89        |
      Intervertebral Disc, Degeneration    |                                           3  2                           |      6  2.7|
      Thoracic, Vertebra, Osteosclerosis   |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |       +                                            +              +      |  11        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
      Inflammation, Chronic Active         |                                  2                       1               |      4  1.8|
      Leukocytosis                         |                                                                          |      1     |
      Pigmentation, Hemosiderin            |                                  2                                       |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                              3                           |      4  2.3|
      Mediastinum, Mineralization          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Nasolacrimal Duct, Hyperplasia,      |                                                                          |            |
          Squamous                         |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                      2              2                                    |      7  2.1|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                  +  +                                    |   5        |
      Phthisis Bulbi                       |                                                                          |      1     |
      Cornea, Inflammation, Chronic Active |                                  4                                       |      2  3.5|
      Cornea, Mineralization               |                                                                          |      1  3.0|
      Lens, Cataract                       |                                     3                                    |      2  3.5|
      Retina, Atrophy                      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  85        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  99        |
      Cyst                                 |                                                                X         |     17     |
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
      Mineralization                       | 1  1     1  1  1  1  1  1        1  1     1  1  1     1     1  1         |     75  1.0|
      Necrosis, Coagulative                |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  82                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 1| 7| 7| 7| 7| 7| 6| 4| 4| 7| 7| 4| 7| 7| 7| 1| 7| 4| 7| 7| 1| 4|  |            |
                             DAY ON TEST   | 3| 3| 6| 3| 1| 2| 3| 2| 2| 5| 5| 2| 3| 5| 3| 3| 0| 6| 3| 5| 3| 3| 6| 5|  |            |
                                           | 6| 6| 6| 7| 5| 9| 7| 9| 5| 9| 8| 9| 7| 9| 7| 7| 1| 6| 0| 8| 7| 7| 5| 8|  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|  |      T     |
                               ANIMAL ID   | 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|  |      A     |
     0 PPM                                 | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|  |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|  |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Nephropathy, Chronic                 | 2  1     2  1  2  2  2  2  2  2  2  2  2  3  2           2  2  2     2   |     76  1.8|
      Artery, Necrosis, Fibrinoid          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  98        |
      Inflammation, Chronic Active         |                         2                                                |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  83                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 4| 6| 5| 6| 2| 6| 2| 5| 5| 0| 6| 7| 6|             
                             DAY ON TEST   | 3| 5| 1| 3| 4| 3| 0| 3| 8| 1| 3| 3| 2| 9| 0| 6| 7| 0| 4| 1| 9| 1| 5| 3| 8|             
                                           | 0| 1| 9| 0| 0| 0| 6| 1| 4| 3| 1| 1| 0| 8| 5| 0| 3| 9| 1| 9| 9| 7| 7| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    SPECIAL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
      Cyst                                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +     +     +     +  +        +  +  M  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
      Basophilic Focus                     |                                           X                              |             
      Clear Cell Focus                     |    X                                   X     X                          X|             
      Clear Cell Focus, Multiple           |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Inflammation, Chronic Active         |                                     2                                    |             
      Necrosis, Coagulative                |                                                                          |             
      Vacuolization Cytoplasmic            |    1        2                             2  2  3     3                 2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                          +               |             
      Inflammation, Necrotizing            |                                                          4               |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
      Diverticulum                         |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Tooth                                   |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
      Dentine, Incisor, Dysplasia          |    4  1     3              3        3  4  3  3              4     3     3|             
      Incisor, Lower, Dysplasia            |    2                    3           3                       4            |             
      Incisor, Ameloblast, Atrophy         |    4        3              3           4  4  3              4     3     3|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
      Mineralization                       |                            1                                             |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
      Hyperplasia                          |                         2                                                |             
      Hypertrophy                          |    2              1     2              1                    1            |             
      Bilateral, Capsule, Spindle Cell,    |                                                                          |             
           Hyperplasia                     |    4                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 4| 6| 5| 6| 2| 6| 2| 5| 5| 0| 6| 7| 6|             
                             DAY ON TEST   | 3| 5| 1| 3| 4| 3| 0| 3| 8| 1| 3| 3| 2| 9| 0| 6| 7| 0| 4| 1| 9| 1| 5| 3| 8|             
                                           | 0| 1| 9| 0| 0| 0| 6| 1| 4| 3| 1| 1| 0| 8| 5| 0| 3| 9| 1| 9| 9| 7| 7| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    SPECIAL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Capsule, Spindle Cell, Hyperplasia   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
      Hyperplasia                          |    3                                      2                 3     2     3|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  M     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
      Ultimobranchial Cyst                 |                                           X                              |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +           +     +  +           +           +     +  +           +|             
      Atrophy                              |    4  4           4     4  4           4           3     3  4           4|             
      Inflammation, Chronic Active         |                         2                          2        3           2|             
      Duct, Dilatation                     |    4  3           3     3  3           3           3     3  4           2|             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |       +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
      Mineralization                       |                                              1                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +     +     M     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  M     +     M     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
      Cyst                                 |                                              X  X                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  M     M     +     M  M        M  M  +  M  M  M  M  M  +  M  +     +|             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +     +     +     +  +        +  +  +  +  +  +  +  M  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
      Intervertebral Disc, Degeneration    |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 4| 6| 5| 6| 2| 6| 2| 5| 5| 0| 6| 7| 6|             
                             DAY ON TEST   | 3| 5| 1| 3| 4| 3| 0| 3| 8| 1| 3| 3| 2| 9| 0| 6| 7| 0| 4| 1| 9| 1| 5| 3| 8|             
                                           | 0| 1| 9| 0| 0| 0| 6| 1| 4| 3| 1| 1| 0| 8| 5| 0| 3| 9| 1| 9| 9| 7| 7| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    SPECIAL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Thoracic, Vertebra, Osteosclerosis   |                                                                          |             
      Tibia, Fracture Healed               |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukocytosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
      Inflammation, Chronic Active         |                            3                                             |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                             +            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +  +     +     +     +  M        +  +  +  M  +  +  +  +  +  +  M     +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
      Cyst                                 |                   X        X                       X                     |             
      Hydronephrosis                       |                         3                                                |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |    1  1     1           1  1        1  1  1  1  1  1  1  1  1     1     1|             
      Nephropathy, Chronic                 |    1  3     1     2     2           2  1  1  1  1  2  1  2  1     2      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +     +     +     +  +        +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 4| 5| 3| 5| 7| 7| 6| 4| 7| 2| 7| 3| 4| 7| 7| 7| 7| 7| 5| 5| 5|            |
                             DAY ON TEST   | 3| 3| 3| 6| 3| 6| 8| 2| 3| 3| 2| 8| 3| 0| 3| 5| 2| 3| 3| 3| 3| 3| 7| 9| 2|            |
                                           | 2| 2| 0| 4| 3| 8| 6| 3| 3| 3| 3| 8| 3| 8| 6| 9| 0| 6| 6| 7| 7| 7| 9| 3| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    SPECIAL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  32        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  32        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  32        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  32        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  32        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  31        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  32        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  32        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  32        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  32        |
                                            __________________________________________________________________________|____________|
   Liver                                   |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  32        |
      Basophilic Focus                     |                                                                          |      1     |
      Clear Cell Focus                     |                X              X  X                                       |      7     |
      Clear Cell Focus, Multiple           |                                                                         X|      1     |
      Eosinophilic Focus                   |                                                                   X  X   |      2     |
      Inflammation, Chronic Active         |                                              4                           |      2  3.0|
      Necrosis, Coagulative                |       2  2                                                              1|      3  1.7|
      Vacuolization Cytoplasmic            |       2        2  3              2     3        2                        |     13  2.2|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                              +                           |   2        |
      Inflammation, Necrotizing            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  32        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  32        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  32        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  32        |
      Diverticulum                         |       2                                                                  |      1  2.0|
      Mineralization                       |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  32        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  32        |
      Dentine, Incisor, Dysplasia          |          4                    3  3           3                       4  3|     17  3.2|
      Incisor, Lower, Dysplasia            |             3                                2                           |      6  2.8|
      Incisor, Ameloblast, Atrophy         |          3                    3  3           3                       4  3|     15  3.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  32        |
      Mineralization                       |                                                 2                        |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  32        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  87                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 4| 5| 3| 5| 7| 7| 6| 4| 7| 2| 7| 3| 4| 7| 7| 7| 7| 7| 5| 5| 5|            |
                             DAY ON TEST   | 3| 3| 3| 6| 3| 6| 8| 2| 3| 3| 2| 8| 3| 0| 3| 5| 2| 3| 3| 3| 3| 3| 7| 9| 2|            |
                                           | 2| 2| 0| 4| 3| 8| 6| 3| 3| 3| 3| 8| 3| 8| 6| 9| 0| 6| 6| 7| 7| 7| 9| 3| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    SPECIAL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  32        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Hypertrophy                          |                2                                                     2   |      7  1.6|
      Bilateral, Capsule, Spindle Cell,    |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  4.0|
      Capsule, Spindle Cell, Hyperplasia   |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  32        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  32        |
      Hyperplasia                          |          2                       2                                       |      7  2.4|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +  +  +  M  +  +        +  +     +     +  +                 +  +  +|  30        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  32        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  32        |
      Ultimobranchial Cyst                 |                                                                          |      1     |
      Follicular Cell, Hyperplasia         |                               1                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  32        |
      Inflammation, Chronic Active         |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |             +                                                        +   |  12        |
      Atrophy                              |                                                                      3   |     11  3.7|
      Inflammation, Chronic Active         |             4                                                            |      5  2.6|
      Duct, Dilatation                     |                                                                      2   |     11  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  32        |
      Inflammation, Chronic Active         |                                              4                           |      1  4.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  32        |
      Inflammation, Chronic Active         |                                              4                           |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  31        |
      Mineralization                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  32        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  32        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  31        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +  +  +  +  +  +        +  +     +     M  +                 +  +  +|  31        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  32        |
      Hematopoietic Cell Proliferation     |       3  4                                   4                           |      3  3.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  88                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 5| 4| 5| 3| 5| 7| 7| 6| 4| 7| 2| 7| 3| 4| 7| 7| 7| 7| 7| 5| 5| 5|            |
                             DAY ON TEST   | 3| 3| 3| 6| 3| 6| 8| 2| 3| 3| 2| 8| 3| 0| 3| 5| 2| 3| 3| 3| 3| 3| 7| 9| 2|            |
                                           | 2| 2| 0| 4| 3| 8| 6| 3| 3| 3| 3| 8| 3| 8| 6| 9| 0| 6| 6| 7| 7| 7| 9| 3| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    SPECIAL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +  +  M  +  +  +        M  +     +     +  +                 +  +  +|  28        |
      Cyst                                 |                                                                         X|      3     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       M  M  M  M  M  M        M  M     +     M  M                 M  M  M|   7        |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  31        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  32        |
      Intervertebral Disc, Degeneration    |                2                                                         |      2  2.0|
      Thoracic, Vertebra, Osteosclerosis   |                1                                                         |      1  1.0|
      Tibia, Fracture Healed               |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  32        |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  32        |
      Leukocytosis                         |                                              X                           |      1     |
                                            __________________________________________________________________________|____________|
   Nose                                    |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  32        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  32        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |       +  +  +  +  M  +        +  M     +     +  +                 +  +  +|  27        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  32        |
      Cyst                                 |                                              X                           |      4     |
      Hydronephrosis                       |                                              4                           |      2  3.5|
      Inflammation, Chronic Active         |                                              4                           |      1  4.0|
      Mineralization                       |       1  1  1  1  1  1        1  1           1  1                    1  1|     28  1.0|
      Nephropathy, Chronic                 |       2  2  1  1  2  1        1  1              1                 3  2  1|     27  1.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +  +  +  +  +  +        +  +     +     +  +                 +  +  +|  32        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  89                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 1| 2| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 1| 1| 4| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 5| 3| 6| 0| 3| 5| 3| 3| 3| 3| 2| 0| 2| 3| 6| 6| 5| 5| 3| 3| 2| 3|             
                                           | 9| 0| 0| 9| 0| 6| 8| 0| 8| 0| 1| 1| 1| 9| 9| 9| 1| 6| 5| 8| 8| 1| 2| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
     25 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  M     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Erosion                              |                                           3                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Lymphoid Tissue, Hyperplasia         |                                                 3                        |             
      Peyer's Patch, Hyperplasia, Lymphoid |                         3                                   4            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Basophilic Focus                     |                               X                                          |             
      Clear Cell Focus                     |          X  X              X     X  X  X     X  X        X           X   |             
      Cytologic Alterations                |                                     X                                    |             
      Eosinophilic Focus                   |                         X                                               X|             
      Fibrosis                             |                                           2                              |             
      Hyperplasia                          |                                           4                              |             
      Inflammation, Chronic Active         |                               2  2  1     2                              |             
      Mineralization                       |                                  2                                       |             
      Necrosis, Coagulative                |                               3           4                              |             
      Vacuolization Cytoplasmic            | 3        2  2     3     2  2                 2              2            |             
      Bile Duct, Hyperplasia               |                                           2                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                               |             
      Inflammation, Necrotizing            |          3                                                               |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                   1      |             
      Acinus, Inflammation, Chronic Active |                                                                          |             
      Acinus, Necrosis, Coagulative        |                               2                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Mineralization                       |                                                                1         |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Dentine, Incisor, Degeneration       |                                                                          |             
      Dentine, Incisor, Dysplasia          | 2  2  4  1  3        3     3  3  4  3  3        1        4  3  2  1  3  4|             
      Gingiva, Incisor, Inflammation,      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 1| 2| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 1| 1| 4| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 5| 3| 6| 0| 3| 5| 3| 3| 3| 3| 2| 0| 2| 3| 6| 6| 5| 5| 3| 3| 2| 3|             
                                           | 9| 0| 0| 9| 0| 6| 8| 0| 8| 0| 1| 1| 1| 9| 9| 9| 1| 6| 5| 8| 8| 1| 2| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
     25 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
          Suppurative                      |                                                                          |             
      Incisor, Lower, Dysplasia            |       4              1     4     3     4                                4|             
      Incisor, Ameloblast, Atrophy         |       4     3        3     3  3  3  3  3                       2     3  4|             
      Peridontal Tissue, Incisor,          |                                                                          |             
          Inflammation, Suppurative        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                                                   X      |             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |    2                 1     1        2                             2  2   |             
      Capsule, Spindle Cell, Hyperplasia   |                         2                    4           3               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Hyperplasia                          |                                                                   2      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  M  +|             
      Pars Distalis, Cyst                  |                                  X              X                        |             
      Pars Distalis, Hyperplasia           |                                                                          |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Follicular Cell, Hyperplasia         |    1        2              2                    2                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                   4      |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +     +        +           +  +  +  +     +           +  +  +  +  +|             
      Atrophy                              |    3  3                             2     4     2              2     3  3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  91                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 1| 2| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 1| 1| 4| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 5| 3| 6| 0| 3| 5| 3| 3| 3| 3| 2| 0| 2| 3| 6| 6| 5| 5| 3| 3| 2| 3|             
                                           | 9| 0| 0| 9| 0| 6| 8| 0| 8| 0| 1| 1| 1| 9| 9| 9| 1| 6| 5| 8| 8| 1| 2| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
     25 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |    4  2                          2  3  2  2     2                        |             
      Duct, Dilatation                     | 4  3  2     3        2           2  2  2  3     2           4  3     2  2|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Cyst                                 |                                              X                           |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Seminiferous Tubule, Degeneration    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Femoral, Myelofibrosis               |                                                                          |             
      Humerus, Myelofibrosis               |                                  1                                       |             
      Maxilla, Myelofibrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Renal, Sinus, Ectasia                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  M  +  +|             
      Hyperplasia, Lymphoid                |                         3                       2           3            |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    3                 3                                         3         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 | X     X                       X        X     X                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  +  M     M  M  M  M  +  M  M  M  M  M  M        M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Humerus, Osteosclerosis              |                                                                          |             
      Intervertebral Disc, Degeneration    |       1                                      2                 3     2  3|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  92                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 1| 2| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 1| 1| 4| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 3| 3| 5| 3| 6| 0| 3| 5| 3| 3| 3| 3| 2| 0| 2| 3| 6| 6| 5| 5| 3| 3| 2| 3|             
                                           | 9| 0| 0| 9| 0| 6| 8| 0| 8| 0| 1| 1| 1| 9| 9| 9| 1| 6| 5| 8| 8| 1| 2| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
     25 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                         2|             
      Alveolar Epithelium, Hyperplasia     |                                                                2         |             
      Bronchus, Dilatation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                            1                             2               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +     +  +  +  +  +  +  +  M  M  +  +        +  M  +  +  M  +|             
      Hyperplasia                          |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Cyst                                 |                                  X                          X        X   |             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Chronic Active         |                                                                3         |             
      Mineralization                       |    1  1     1        1     1  1  1  1  1  1  1  1              1  1  1  1|             
      Nephropathy, Chronic                 | 2  2  2  2  2        2  2  2  1  2  2  2  2  2  2        2  2  1  2  2  3|             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Calculus Gross Observation           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 1| 1| 7| 6| 4| 4| 7| 1| 7| 7| 1| 7| 6| 7| 7| 7| 6| 7| 7| 1| 4|             
                             DAY ON TEST   | 2| 3| 0| 2| 6| 6| 2| 2| 5| 5| 3| 6| 2| 3| 6| 2| 2| 2| 3| 3| 5| 3| 2| 6| 5|             
                                           | 9| 2| 7| 9| 5| 6| 8| 9| 8| 9| 2| 6| 9| 3| 5| 9| 4| 9| 3| 3| 7| 3| 9| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
     25 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  M        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
      Erosion                              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
      Lymphoid Tissue, Hyperplasia         |                                                                          |             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
      Basophilic Focus                     |                   X                                X        X            |             
      Clear Cell Focus                     |                         X  X        X        X  X  X           X  X     X|             
      Cytologic Alterations                |                                                                          |             
      Eosinophilic Focus                   |                            X  X              X        X        X         |             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          |          4                                                               |             
      Inflammation, Chronic Active         | 2                             2                                   2      |             
      Mineralization                       |                                                                          |             
      Necrosis, Coagulative                |                      3                                      2            |             
      Vacuolization Cytoplasmic            |                         3  2        2        1  2                 2     2|             
      Bile Duct, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +                                          |             
      Inflammation, Necrotizing            |                               4                                          |             
      Mineralization                       |                               2                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
      Acinus, Atrophy                      |                                                                          |             
      Acinus, Inflammation, Chronic Active |                               2                                          |             
      Acinus, Necrosis, Coagulative        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
      Acanthosis                           |                                                    3                     |             
      Inflammation, Chronic Active         |                                                    3                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
      Erosion                              |                      2                                                   |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
      Dentine, Incisor, Degeneration       |                                                                          |             
      Dentine, Incisor, Dysplasia          | 1  3     2        3  1     1  3     1  2     2  4  3  3  1  4  3  1     2|             
      Gingiva, Incisor, Inflammation,      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  94                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 1| 1| 7| 6| 4| 4| 7| 1| 7| 7| 1| 7| 6| 7| 7| 7| 6| 7| 7| 1| 4|             
                             DAY ON TEST   | 2| 3| 0| 2| 6| 6| 2| 2| 5| 5| 3| 6| 2| 3| 6| 2| 2| 2| 3| 3| 5| 3| 2| 6| 5|             
                                           | 9| 2| 7| 9| 5| 6| 8| 9| 8| 9| 2| 6| 9| 3| 5| 9| 4| 9| 3| 3| 7| 3| 9| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
     25 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
          Suppurative                      |    2                                                                     |             
      Incisor, Lower, Dysplasia            |                   3                                4                     |             
      Incisor, Ameloblast, Atrophy         |    3              3           4                 4  3  3     4  3         |             
      Peridontal Tissue, Incisor,          |                                                                          |             
          Inflammation, Suppurative        |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                       +                  |             
      Inflammation, Chronic Active         |                                                       3                  |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
      Cardiomyopathy, Chronic              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
      Accessory Adrenal Cortical Nodule    |                                                          X               |             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |    2              2                    2     2     1           2         |             
      Capsule, Spindle Cell, Hyperplasia   | 3                    4        4     4                                    |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
      Hyperplasia                          |                                                          2               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
      Hyperplasia                          |                   2                             2           2            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +        M  +  +  +  +     +  +     +  +  +  M  +  +  M  +     +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
      Pars Distalis, Cyst                  |    X                                                                     |             
      Pars Distalis, Hyperplasia           |                               2                                          |             
      Pars Intermedia, Cyst                |       X                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
      Inflammation, Chronic Active         |                                              2                           |             
      Follicular Cell, Hyperplasia         |                                                          2        2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
      Granuloma Sperm                      |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +     +        +           +     +  +     +     +  +  +     +         |             
      Atrophy                              | 2  2              4           3     2  1     3     4  2  3     2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 1| 1| 7| 6| 4| 4| 7| 1| 7| 7| 1| 7| 6| 7| 7| 7| 6| 7| 7| 1| 4|             
                             DAY ON TEST   | 2| 3| 0| 2| 6| 6| 2| 2| 5| 5| 3| 6| 2| 3| 6| 2| 2| 2| 3| 3| 5| 3| 2| 6| 5|             
                                           | 9| 2| 7| 9| 5| 6| 8| 9| 8| 9| 2| 6| 9| 3| 5| 9| 4| 9| 3| 3| 7| 3| 9| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
     25 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |    2                          2                    2  2        2         |             
      Duct, Dilatation                     | 2                 3           3     2  2     3     3  2  2     3         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
      Inflammation, Chronic Active         |                               2                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |          2                    4                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
      Seminiferous Tubule, Degeneration    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
      Femoral, Myelofibrosis               |                                                                          |             
      Humerus, Myelofibrosis               |                                                                          |             
      Maxilla, Myelofibrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
      Renal, Sinus, Ectasia                |                               3                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
      Hyperplasia, Lymphoid                |                                                                2         |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
      Hematopoietic Cell Proliferation     |    2     2                                            2                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +        +  +  +  +  +     +  M     +  +  +  +  +  +  M  +     +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                         X  X        X                 X                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M        M  M  M  M  M     M  M     M  M  M  M  M  M  M  M     M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
      Humerus, Osteosclerosis              |       2                                                                  |             
      Intervertebral Disc, Degeneration    |       2  2                                                        2      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
      Infiltration Cellular, Lymphocyte    |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  96                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 1| 1| 7| 6| 4| 4| 7| 1| 7| 7| 1| 7| 6| 7| 7| 7| 6| 7| 7| 1| 4|             
                             DAY ON TEST   | 2| 3| 0| 2| 6| 6| 2| 2| 5| 5| 3| 6| 2| 3| 6| 2| 2| 2| 3| 3| 5| 3| 2| 6| 5|             
                                           | 9| 2| 7| 9| 5| 6| 8| 9| 8| 9| 2| 6| 9| 3| 5| 9| 4| 9| 3| 3| 7| 3| 9| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
     25 PPM                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                                                          2               |             
      Alveolar Epithelium, Hyperplasia     |                         3                                2     2         |             
      Bronchus, Dilatation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                               2                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  M  +  +        +  +  M  +  +     +  +     +  M  M  +  +  +  +  +     +|             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
      Cyst                                 |    X     X                    X     X                    X               |             
      Hydronephrosis                       |                                                          4               |             
      Inflammation, Chronic Active         |                               3                                          |             
      Mineralization                       | 1  1  1  1        1  1        1     1  1     1  1  1  1     1  1  1      |             
      Nephropathy, Chronic                 | 2  2     2        1     2  2  2     2  1     2     2  2  1  2  2  2     2|             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                          +               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +        +  +  +  +  +     +  +     +  +  +  +  +  +  +  +     +|             
      Calculus Gross Observation           |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  97                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 6| 7| 7| 7| 7| 1| 7| 4| 5| 1| 7| 6| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 1| 5| 5| 3| 3| 3| 2| 6| 3| 5| 4| 6| 3| 8| 3| 3| 3| 3|              |            |
                                           | 3| 6| 9| 8| 6| 6| 6| 6| 9| 5| 6| 8| 0| 5| 7| 4| 7| 7| 7| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|              |      A     |
     25 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
      Erosion                              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
      Lymphoid Tissue, Hyperplasia         |                                                          3               |      2  3.0|
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
      Basophilic Focus                     |                X                                   X                     |      6     |
      Clear Cell Focus                     |    X     X     X        X     X  X                 X     X               |     27     |
      Cytologic Alterations                |                                                                          |      1     |
      Eosinophilic Focus                   |                   X                                   X                  |      9     |
      Fibrosis                             |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      2  4.0|
      Inflammation, Chronic Active         |                                                                          |      7  1.9|
      Mineralization                       |                                                                          |      1  2.0|
      Necrosis, Coagulative                |                                              2                           |      5  2.8|
      Vacuolization Cytoplasmic            |          2              2        2                                       |     18  2.1|
      Bile Duct, Hyperplasia               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                    +                    +                           |   5        |
      Inflammation, Necrotizing            |    4                    4                                                |      4  3.8|
      Mineralization                       |                         1                                                |      2  1.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
      Acinus, Atrophy                      |                                                                          |      1  1.0|
      Acinus, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Acinus, Necrosis, Coagulative        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
      Acanthosis                           |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
      Erosion                              |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  98                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 6| 7| 7| 7| 7| 1| 7| 4| 5| 1| 7| 6| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 1| 5| 5| 3| 3| 3| 2| 6| 3| 5| 4| 6| 3| 8| 3| 3| 3| 3|              |            |
                                           | 3| 6| 9| 8| 6| 6| 6| 6| 9| 5| 6| 8| 0| 5| 7| 4| 7| 7| 7| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|              |      A     |
     25 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                                                    1                     |      2  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
      Dentine, Incisor, Degeneration       |                                                    3                     |      1  3.0|
      Dentine, Incisor, Dysplasia          | 3     4  3     2  3  1  2     1  2  3     4  3  1  2  4  3               |     52  2.5|
      Gingiva, Incisor, Inflammation,      |                                                                          |            |
          Suppurative                      |                                                                          |      1  2.0|
      Incisor, Lower, Dysplasia            | 2     2        1  2                 2                 3                  |     14  2.8|
      Incisor, Ameloblast, Atrophy         | 3     4        3  3  3              3     4  3        4  3               |     29  3.2|
      Peridontal Tissue, Incisor,          |                                                                          |            |
          Inflammation, Suppurative        |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
      Cardiomyopathy, Chronic              |    2                                                                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1     |
      Atrophy                              | 3                                                                        |      1  3.0|
      Cyst                                 |                                                          X               |      2     |
      Hyperplasia                          |                                                    2                     |      1  2.0|
      Hypertrophy                          |    2        1           2                                2               |     16  1.8|
      Capsule, Spindle Cell, Hyperplasia   |                3                                                         |      8  3.4|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
      Hyperplasia                          |                   2                 3     2                              |      7  2.1|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  M  +  +  +     +  +  +     +  +  +  +  +  +               |  55        |
      Cyst                                 |                   X                                                      |      1     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  59        |
      Pars Distalis, Cyst                  |    X                 X                          X                        |      6     |
      Pars Distalis, Hyperplasia           |                                                                          |      1  2.0|
      Pars Intermedia, Cyst                |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Follicular Cell, Hyperplasia         |       2              2                          2  2                     |     10  1.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  99                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 6| 7| 7| 7| 7| 1| 7| 4| 5| 1| 7| 6| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 1| 5| 5| 3| 3| 3| 2| 6| 3| 5| 4| 6| 3| 8| 3| 3| 3| 3|              |            |
                                           | 3| 6| 9| 8| 6| 6| 6| 6| 9| 5| 6| 8| 0| 5| 7| 4| 7| 7| 7| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|              |      A     |
     25 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
      Granuloma Sperm                      |                                                    2                     |      2  3.0|
      Mineralization                       |                                              1                           |      1  1.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +  +     +  +  +  +              +     +  +  +  +  +  +               |  40        |
      Atrophy                              |    2        4  2  4  4              3     4  4  3  3  2                  |     30  2.8|
      Inflammation, Chronic Active         |    2              2  1                    2  2     2                     |     18  2.1|
      Duct, Dilatation                     |    2  3     3  3  2  2              3     2  4  3  2  3                  |     36  2.6|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
      Cyst                                 |                                                                          |      1     |
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
      Seminiferous Tubule, Degeneration    |                   1  2                                                   |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
      Femoral, Myelofibrosis               |                1                                                         |      1  1.0|
      Humerus, Myelofibrosis               |                                                                          |      1  1.0|
      Maxilla, Myelofibrosis               |                      1              2                                    |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
      Renal, Sinus, Ectasia                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  59        |
      Hyperplasia, Lymphoid                |                                                                          |      4  2.5|
      Thrombosis                           |                      X                                                   |      1     |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
      Hematopoietic Cell Proliferation     |                      2              3        4     2                     |     10  2.6|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  M  +     +  +  M     M  M  +  +  +  +               |  52        |
      Atrophy                              |                   2                                   2                  |      2  2.0|
      Cyst                                 |          X     X  X              X                                       |     13     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  +  M  M  M  M  +  M     M  M  M     M  M  M  M  M  M               |   4        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 100                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 4| 6| 7| 7| 7| 7| 1| 7| 4| 5| 1| 7| 6| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 1| 5| 5| 3| 3| 3| 2| 6| 3| 5| 4| 6| 3| 8| 3| 3| 3| 3|              |            |
                                           | 3| 6| 9| 8| 6| 6| 6| 6| 9| 5| 6| 8| 0| 5| 7| 4| 7| 7| 7| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|              |      A     |
     25 PPM                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
      Humerus, Osteosclerosis              |                                                                          |      1  2.0|
      Intervertebral Disc, Degeneration    |                1     2                                                   |     10  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |       +                                                                  |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      4  2.3|
      Bronchus, Dilatation                 |             4                                                            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                   1                 3                                    |      5  1.8|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  M  +  M  +  +  +  +     +  M  +     +  +  +  +  +  +               |  49        |
      Hyperplasia                          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
      Cyst                                 |    X                                            X                        |     10     |
      Hydronephrosis                       |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
      Mineralization                       | 1  1  1     1  1  1     1     1     1     1  1  1  1  1  1               |     47  1.0|
      Nephropathy, Chronic                 | 2  2  1  2  1  2  2  3  2     2  2  1     2  1  2  1  2  2               |     56  1.9|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +               |  60        |
      Calculus Gross Observation           |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 101                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 5| 4| 4| 4| 7| 2| 7| 5| 7| 4| 6| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 5| 2| 3| 2| 0| 5| 5| 5| 3| 4| 2| 2| 3| 5| 2| 3| 9| 5| 3| 3| 3| 2| 3| 6| 2|             
                                           | 8| 9| 0| 9| 5| 8| 9| 9| 0| 1| 9| 8| 0| 9| 6| 0| 8| 1| 0| 0| 0| 9| 1| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
     100 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Intussusception                      |                                                       X                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                         X                                                |             
      Clear Cell Focus                     |    X  X  X              X        X  X        X        X  X  X  X         |             
      Eosinophilic Focus                   |          X                    X  X                          X            |             
      Inflammation, Chronic Active         |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Coagulative                |                                                 4        1               |             
      Vacuolization Cytoplasmic            | 2  2  2        3  3  1  2           2  2                                 |             
      Bile Duct, Cyst                      |    X                                                                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                       +              +           +               |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Necrotizing            |       4                                      4           4               |             
      Mineralization                       |       3                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Amyloid Deposition           |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Cyst Epithelial Inclusion            |                                                                X         |             
      Diverticulum                         |                                                       2                  |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Mineralization                       |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                            4                                             |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dentine, Incisor, Dysplasia          |    3  3  3  3     1  3        4  4  1     4  1     1  1  4  1  1  1  4  4|             
      Incisor, Lower, Dysplasia            |    2        4                 3  4        3                    2     2  2|             
      Incisor, Ameloblast, Atrophy         |    3  3  3  3                 4  4        4              4        3  4  4|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 102                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 5| 4| 4| 4| 7| 2| 7| 5| 7| 4| 6| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 5| 2| 3| 2| 0| 5| 5| 5| 3| 4| 2| 2| 3| 5| 2| 3| 9| 5| 3| 3| 3| 2| 3| 6| 2|             
                                           | 8| 9| 0| 9| 5| 8| 9| 9| 0| 1| 9| 8| 0| 9| 6| 0| 8| 1| 0| 0| 0| 9| 1| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
     100 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Pulp, Incisor, Inflammation,         |                                                                          |             
          Suppurative                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                            +                                             |             
      Aorta, Inflammation, Chronic Active  |                            4                                             |             
      Mesenteric Artery, Inflammation,     |                                                                          |             
           Chronic Active                  |                            4                                             |             
      Thoracic, Artery, Inflammation,      |                                                                          |             
          Chronic Active                   |                            4                                             |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                            4                                             |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |          2                                                               |             
      Hypertrophy                          |    1  2                             2  2  2           1  2  2  2         |             
      Bilateral, Capsule, Spindle Cell,    |                                                                          |             
           Hyperplasia                     |                                                                          |             
      Capsule, Spindle Cell, Hyperplasia   |                      2  3        3                             3         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      2        2  2        2                       2  3  2|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Pars Distalis, Cyst                  |    X                                                           X         |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                            4                                             |             
      Ultimobranchial Cyst                 |       X                                                                  |             
      Follicular Cell, Hyperplasia         |                                                                   1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                       1        2         |             
                                            __________________________________________________________________________|             
   Penis                                   |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 103                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 5| 4| 4| 4| 7| 2| 7| 5| 7| 4| 6| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 5| 2| 3| 2| 0| 5| 5| 5| 3| 4| 2| 2| 3| 5| 2| 3| 9| 5| 3| 3| 3| 2| 3| 6| 2|             
                                           | 8| 9| 0| 9| 5| 8| 9| 9| 0| 1| 9| 8| 0| 9| 6| 0| 8| 1| 0| 0| 0| 9| 1| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
     100 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +     +        +           +  +     +     +        +  +        +  +   |             
      Atrophy                              |    2                          2  3           2        2  2        2  4   |             
      Inflammation, Chronic Active         |          4                    2              2        3              2   |             
      Duct, Dilatation                     |    4     4        4           2  4     4     2        4  2        4  4   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                          X               |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                               3     2                                    |             
      Necrosis, Coagulative                |                               4                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Myelofibrosis               |                                                                          |             
      Humerus, Myelofibrosis               |                                                                          |             
      Tibia, Myelofibrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             |                                           2              3               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                         3|             
      Hematopoietic Cell Proliferation     |          3                                            3                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  I  M  +  +  +  +  +  +  M  +  +  M  +  +  +  M|             
      Cyst                                 |                                           X  X                    X      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calvarium, Osteosclerosis, Focal     |                                                                          |             
      Intervertebral Disc, Degeneration    |                               3     1                                    |             
      Rib, Cartilage, Degeneration         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                            2                                      2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 104                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 5| 4| 4| 4| 7| 2| 7| 5| 7| 4| 6| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 5| 2| 3| 2| 0| 5| 5| 5| 3| 4| 2| 2| 3| 5| 2| 3| 9| 5| 3| 3| 3| 2| 3| 6| 2|             
                                           | 8| 9| 0| 9| 5| 8| 9| 9| 0| 1| 9| 8| 0| 9| 6| 0| 8| 1| 0| 0| 0| 9| 1| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
     100 PPM                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |    2           2                 3                                       |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |             1                                                            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                            +                                      +      |             
      Middle Ear, Inflammation, Suppurative|                            3                                             |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  M  +  +|             
      Inflammation, Chronic Active         |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                               X                       X     X            |             
      Inflammation, Necrotizing            |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |    1  1  1  1           1        1  1     1  1  1  1  1  1  1  1  1  1  1|             
      Nephropathy, Chronic                 | 1  2  2  2     1  1  1  2     1     2     1  1  2  1  2  2  2  1  2  2   |             
      Renal Tubule, Epithelium, Hyperplasia|                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                      X   |             
      Inflammation, Chronic Active         |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 105                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 1| 1| 7| 1| 4| 7| 6| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 6| 5| 7| 1|             
                             DAY ON TEST   | 3| 6| 3| 3| 6| 6| 3| 6| 5| 3| 1| 3| 2| 3| 3| 3| 2| 6| 2| 3| 3| 9| 7| 3| 6|             
                                           | 1| 0| 1| 1| 6| 5| 2| 6| 9| 2| 9| 2| 9| 2| 3| 3| 9| 5| 9| 3| 3| 2| 9| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
     100 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +        +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +        +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +        +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +        +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +        +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +        +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +        +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +        +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +   |             
      Intussusception                      |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +        +     +  +  +  +  +  +  +  +  +     +  +  +  M  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +        +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +   |             
      Lymphoid Tissue, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +        +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     | X  X  X  X        X        X        X  X              X  X     X     X   |             
      Eosinophilic Focus                   |          X              X        X        X                              |             
      Inflammation, Chronic Active         |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Coagulative                |    4                                                                     |             
      Vacuolization Cytoplasmic            | 2                       3              2                                 |             
      Bile Duct, Cyst                      |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                 +                                               +   |             
      Inflammation, Chronic Active         |                      3                                                   |             
      Inflammation, Necrotizing            |    4                                                                 4   |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +        +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +   |             
      Acinus, Amyloid Deposition           |                                  1                                       |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +        +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +        +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +        +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +   |             
      Acanthosis                           |                                                             3            |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Diverticulum                         |                                                                          |             
      Inflammation, Chronic Active         |                                                             2            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +        +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +   |             
      Erosion                              |    2                                                                     |             
      Mineralization                       |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +        +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +   |             
      Dentine, Incisor, Dysplasia          | 1  1     4        4     1  1  3  4  3  2  4  1  1     1  3  4        1   |             
      Incisor, Lower, Dysplasia            |                   3              4        3     3                        |             
      Incisor, Ameloblast, Atrophy         |    2     4        4           4  4  3     4              3  4            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 106                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 1| 1| 7| 1| 4| 7| 6| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 6| 5| 7| 1|             
                             DAY ON TEST   | 3| 6| 3| 3| 6| 6| 3| 6| 5| 3| 1| 3| 2| 3| 3| 3| 2| 6| 2| 3| 3| 9| 7| 3| 6|             
                                           | 1| 0| 1| 1| 6| 5| 2| 6| 9| 2| 9| 2| 9| 2| 3| 3| 9| 5| 9| 3| 3| 2| 9| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
     100 PPM                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Pulp, Incisor, Inflammation,         |                                                                          |             
          Suppurative                      |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Inflammation, Chronic Active  |                                                                          |             
      Mesenteric Artery, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
      Thoracic, Artery, Inflammation,      |                                                                          |             
          Chronic Active                   |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +        +     +  +  +  +  +  +     +  +     +  +  +  +  +  +   |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +        +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +        +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +   |             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                               1                                          |             
      Hypertrophy                          | 2        2                       2           2  1     2  1  2        2   |             
      Bilateral, Capsule, Spindle Cell,    |                                                                          |             
           Hyperplasia                     |                                                                          |             
      Capsule, Spindle Cell, Hyperplasia   |    3                                         2              3        3   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +        +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +        +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +   |             
      Hyperplasia                          | 1                 2           2  2  1     2                 2            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +        +     +  +  +  +  +  +  +  +  +     M  +  +  M  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  +  +        +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +   |             
      Pars Distalis, Cyst                  | X                 X                                      X               |             
      Pars Distalis, Hyperplasia           |       2                                      2                           |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +        +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +   |             
      Inflammation, Chronic Active         |                                                                          |             
      Ultimobranchial Cyst                 |                                                                          |             
      Follicular Cell, Hyperplasia         |       1                          1           2                 1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +        +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +   |             
      Inflammation, Chronic Active         |                            2                                             |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 107                                                               
NTP Experiment-Test: 05131-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:53  
                                                                                                                                    
 _____________________________________________________________________________________________________________________