National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2264

TR 393 Rat Pathology Tables

NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97
Route: DOSED WATER                                                                                                Time: 18:55:37




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  7681-49-4

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 1| 5| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6| 1| 7| 7| 1| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 2| 8| 0| 3| 3| 3| 3| 6| 3| 3| 8| 1| 3| 3| 7| 8| 3| 3| 8| 3| 3| 3| 2| 3|             
                                           | 0| 9| 4| 9| 0| 0| 0| 0| 0| 0| 0| 3| 9| 0| 0| 7| 4| 0| 0| 5| 0| 0| 1| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
     0 PPM                                 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |    X        X  X  X  X        X           X        X  X     X     X     X|             
      Clear Cell Focus                     |                                                    X           X        X|             
      Congestion                           |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |                X  X                                                      |             
      Hyperplasia                          |                                              3                           |             
      Inflammation, Chronic Active         |                2  3     1     2        2           3  1        1        2|             
      Vacuolization Cytoplasmic            |                            2     4        1                 1            |             
      Bile Duct, Hyperplasia               | 1                    1           3  2        3                    2      |             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +                           |             
      Inflammation, Chronic Active         |                                                                          |             
      Fat, Inflammation, Chronic Active    |                                              4                           |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |             1  1           2                                1            |             
      Artery, Inflammation, Chronic Active |                   2                                                      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Cytomegaly                   |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                      2   |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Mineralization                       |          3                                                               |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dentine, Dentine, Incisor, Incisor,  |                                                                          |             
           Necrosis, Multifocal, Multifocal|                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 1| 5| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6| 1| 7| 7| 1| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 2| 8| 0| 3| 3| 3| 3| 6| 3| 3| 8| 1| 3| 3| 7| 8| 3| 3| 8| 3| 3| 3| 2| 3|             
                                           | 0| 9| 4| 9| 0| 0| 0| 0| 0| 0| 0| 3| 9| 0| 0| 7| 4| 0| 0| 5| 0| 0| 1| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
     0 PPM                                 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Dentine, Incisor, Necrosis, Focal    |                            1           1  1                              |             
      Dentine, Incisor, Necrosis,          |                                                                          |             
          Multifocal                       |    1        1  1  1  1        1  2  1        1     2  1     1  1  1  1  1|             
      Peridontal Tissue, Incisor,          |                                                                          |             
          Inflammation, Necrotizing        |                                                                          |             
      Peridontal Tissue, Molar,            |                                                                          |             
          Inflammation, Suppurative        |                                     4                                    |             
      Peridontal Tissue, Molar, Lower,     |                                                                          |             
           Inflammation, Chronic,          |                                                                          |             
          Suppurative                      |                                                                          |             
      Peridontal Tissue, Molar, Lower,     |                                                                          |             
           Inflammation, Chronic,          |                                                                          |             
          Suppurative                      |    4     2                             3                    2           3|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Chronic                | 1              2  1  1  1     2  2  2  2  1        2  2     2  2  2  2  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                   X                                                      |             
      Congestion                           |                                                                          |             
      Degeneration, Cystic                 |                                     3                                    |             
      Hyperplasia                          |             2                          2              2                  |             
      Hypertrophy                          |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Bilateral, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Congestion            |                   1           4                    3                     |             
      Pars Distalis, Cyst                  |                      X              X                                   X|             
      Pars Distalis, Hemorrhage            |                3                                                         |             
      Pars Distalis, Hyperplasia           |       2                       3                                          |             
      Pars Intermedia, Cyst                |                                     X                                    |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
      Rathke's Cleft, Cyst                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 1| 5| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6| 1| 7| 7| 1| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 2| 8| 0| 3| 3| 3| 3| 6| 3| 3| 8| 1| 3| 3| 7| 8| 3| 3| 8| 3| 3| 3| 2| 3|             
                                           | 0| 9| 4| 9| 0| 0| 0| 0| 0| 0| 0| 3| 9| 0| 0| 7| 4| 0| 0| 5| 0| 0| 1| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
     0 PPM                                 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Glandular               |                                        2                                 |             
      Inflammation, Chronic Active         |                                                             2            |             
      Duct, Cyst                           |                                        X                                 |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                                                          |             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cervix, Cyst                         |                                                                          |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       | 2           2           3                                            3   |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Exudate                              |                                                                          |             
      Prolapse                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Congestion              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid, Nodular       |                                                                3         |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
      Infiltration Cellular, Lipocyte      |                                                                3         |             
      Necrosis                             |                                              3                           |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |    4        3  2  3  4     3     3  2  3  2        4  4     3  3  3  2  2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |    3     2  2  4  4  3     3  3  3  2  2     2     3  3     4  1  3  3  3|             
      Mineralization                       |          2                                                               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Humerus, Osteosclerosis              |                      1                                                   |             
      Mandible, Fibrous Osteodystrophy     | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 1| 5| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 6| 1| 7| 7| 1| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 2| 8| 0| 3| 3| 3| 3| 6| 3| 3| 8| 1| 3| 3| 7| 8| 3| 3| 8| 3| 3| 3| 2| 3|             
                                           | 0| 9| 4| 9| 0| 0| 0| 0| 0| 0| 0| 3| 9| 0| 0| 7| 4| 0| 0| 5| 0| 0| 1| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
     0 PPM                                 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Thoracic, Vertebra, Fibrous          |                                                                          |             
          Osteodystrophy                   |                                                                          |             
      Thoracic, Vertebra, Osteosclerosis   |                      1                             3                     |             
      Tibia, Fibrous Osteodystrophy        |                                                                          |             
      Tibia, Osteosclerosis                |                      1                             3                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Myelin, Degeneration                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                  2                                       |             
      Inflammation, Chronic Active         |                                  2                                       |             
      Alveolar Epithelium, Hyperplasia     |             2                                                            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Squamous                 |                                                                          |             
      Mucosa, Inflammation, Acute          |          2                                                               |             
      Mucosa, Inflammation, Chronic Active |                                  3        3                              |             
      Mucosa, Ulcer                        |          2                                                               |             
      Sinus, Foreign Body                  |                                  2        3                              |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                     +                                    |             
                                            __________________________________________________________________________|             
   Eye                                     |                +     +     +  +  +  +                                    |             
      Anterior Chamber, Hemorrhage         |                                                                          |             
      Lens, Cataract                       |                3     3     3  3  4  3                                    |             
      Retina, Atrophy                      |                4     4     4  4  4  4                                    |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 1     1     3  2  2  1  1  3  2     2  2  1        2  2     2  1  3  1  3|             
      Cortex, Cyst                         |                                                                         X|             
      Renal Tubule, Mineralization         |       2                                         2        2               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1| 6| 6| 6| 3| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 3| 9| 3| 3| 3| 6| 2| 3| 4| 2| 3| 3| 2| 3| 3| 8| 7| 3| 8| 7| 3| 3| 4| 2|             
                                           | 9| 1| 1| 1| 1| 1| 0| 9| 1| 3| 9| 1| 1| 9| 1| 1| 4| 4| 4| 2| 6| 2| 2| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
     0 PPM                                 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                   1      |             
      Basophilic Focus                     | X              X  X     X     X  X  X  X  X  X        X        X  X     X|             
      Clear Cell Focus                     |                                        X  X                       X     X|             
      Congestion                           |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                   X  X   |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |                1              2           2                 1  3     2   |             
      Vacuolization Cytoplasmic            |       2                    4                       3                     |             
      Bile Duct, Hyperplasia               |    1     3  4        2     3  2              2              2     2      |             
      Centrilobular, Necrosis              |                                                       3                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Fat, Inflammation, Chronic Active    |                                                                          |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                    +                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                2              1        1        2           2            |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Cytomegaly                   |                2                                                         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                 3                        |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                            2                                             |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dentine, Dentine, Incisor, Incisor,  |                                                                          |             
           Necrosis, Multifocal, Multifocal|                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1| 6| 6| 6| 3| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 3| 9| 3| 3| 3| 6| 2| 3| 4| 2| 3| 3| 2| 3| 3| 8| 7| 3| 8| 7| 3| 3| 4| 2|             
                                           | 9| 1| 1| 1| 1| 1| 0| 9| 1| 3| 9| 1| 1| 9| 1| 1| 4| 4| 4| 2| 6| 2| 2| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
     0 PPM                                 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Dentine, Incisor, Necrosis, Focal    |                                                                          |             
      Dentine, Incisor, Necrosis,          |                                                                          |             
          Multifocal                       | 1  1  1     1  1     1  1  1  1  1     1  1  1     1  1  1     1  1  1  1|             
      Peridontal Tissue, Incisor,          |                                                                          |             
          Inflammation, Necrotizing        |                                                    3                     |             
      Peridontal Tissue, Molar,            |                                                                          |             
          Inflammation, Suppurative        |             2                                                            |             
      Peridontal Tissue, Molar, Lower,     |                                                                          |             
           Inflammation, Chronic,          |                                                                          |             
          Suppurative                      |                                                                          |             
      Peridontal Tissue, Molar, Lower,     |                                                                          |             
           Inflammation, Chronic,          |                                                                          |             
          Suppurative                      | 3  3                                         3                    2     3|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Chronic                |    1  2     1  1     2  1  3  2     1  1  1  2        1  3  1  1  2     1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Congestion                           |                                                                          |             
      Degeneration, Cystic                 |       2                                                                  |             
      Hyperplasia                          |                         2     2     2        2                 2  2      |             
      Hypertrophy                          |                                  2                                       |             
      Vacuolization Cytoplasmic, Focal     |          2                                            2                  |             
      Bilateral, Hyperplasia               |                                                       4                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                            4                                             |             
      Hyperplasia                          |                               2        2                                 |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Congestion            | 2                       2        3  3  3  3  4                 4  2     4|             
      Pars Distalis, Cyst                  |             X     X                          X     X              X  X   |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           |                   2                       3                    3  2     2|             
      Pars Intermedia, Cyst                |                                                                          |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
      Rathke's Cleft, Cyst                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                2     2        2              2                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1| 6| 6| 6| 3| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 3| 9| 3| 3| 3| 6| 2| 3| 4| 2| 3| 3| 2| 3| 3| 8| 7| 3| 8| 7| 3| 3| 4| 2|             
                                           | 9| 1| 1| 1| 1| 1| 0| 9| 1| 3| 9| 1| 1| 9| 1| 1| 4| 4| 4| 2| 6| 2| 2| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
     0 PPM                                 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Glandular               |                               2     2                                    |             
      Inflammation, Chronic Active         |                                  2  2                                    |             
      Duct, Cyst                           |                                                          X               |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                                       X                  |             
      Periovarian Tissue, Cyst             |                                                                      X   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cervix, Cyst                         |                                                                   X      |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |                                                                   3      |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                       +        +         |             
      Exudate                              |                                                                          |             
      Prolapse                             |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Congestion              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                                                                      3   |             
      Inflammation, Chronic Active         |                                                       3                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                               2                                          |             
      Hematopoietic Cell Proliferation     |                                                       4                  |             
      Hyperplasia, Lymphoid, Nodular       |                                                                          |             
      Hyperplasia, Reticulum Cell          |                                           2                              |             
      Infiltration Cellular, Lipocyte      |                                                                          |             
      Necrosis                             |                            3                                             |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  M  +  M  +|             
      Depletion Lymphoid                   | 3  3  3     3  3     1  2     2  2  3  3     2     3     3        2     2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 3  3  4  4  3  4     3  3  4  2  2  3  3  3  3  2  4  4  3     4  2  3  3|             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Humerus, Osteosclerosis              |                                                                          |             
      Mandible, Fibrous Osteodystrophy     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 1| 6| 6| 6| 3| 7| 7| 6| 7|             
                             DAY ON TEST   | 2| 3| 9| 3| 3| 3| 6| 2| 3| 4| 2| 3| 3| 2| 3| 3| 8| 7| 3| 8| 7| 3| 3| 4| 2|             
                                           | 9| 1| 1| 1| 1| 1| 0| 9| 1| 3| 9| 1| 1| 9| 1| 1| 4| 4| 4| 2| 6| 2| 2| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
     0 PPM                                 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Thoracic, Vertebra, Fibrous          |                                                                          |             
          Osteodystrophy                   |                                                                          |             
      Thoracic, Vertebra, Osteosclerosis   |                                                                          |             
      Tibia, Fibrous Osteodystrophy        |                                                                          |             
      Tibia, Osteosclerosis                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |       X                                                                  |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |       2                                                                  |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Myelin, Degeneration                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Squamous                 |                                                                          |             
      Mucosa, Inflammation, Acute          |                                                                          |             
      Mucosa, Inflammation, Chronic Active |                                              2                    3     3|             
      Mucosa, Ulcer                        |                                                                          |             
      Sinus, Foreign Body                  |                                                                         3|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                        +                             +   |             
                                            __________________________________________________________________________|             
   Eye                                     |       +        +     +  +                          +                     |             
      Anterior Chamber, Hemorrhage         |                                                    3                     |             
      Lens, Cataract                       |       4        3     3  3                                                |             
      Retina, Atrophy                      |       4        4     4  4                                                |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 3  3  3  2  1  3  1  1  2  2  1  1  2  2     1     2  3  3  3  2  2     1|             
      Cortex, Cyst                         |                                                                          |             
      Renal Tubule, Mineralization         |                                                 1                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 6| 2| 4| 7| 1| 7| 7| 7| 7| 4| 7| 7| 6| 7| 1| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 8| 2| 3| 6| 5| 3| 8| 2| 3| 3| 3| 6| 3| 3| 6| 2| 8| 3| 3| 3| 4| 3| 3|             
                                           | 2| 2| 5| 9| 0| 0| 9| 2| 4| 9| 2| 2| 2| 3| 2| 2| 3| 9| 4| 2| 3| 3| 6| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
     0 PPM                                 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | X  X     X                 X  X  X  X     X  X     X     X  X  X  X  X  X|             
      Clear Cell Focus                     |                                           X                              |             
      Congestion                           |                                        3                                 |             
      Eosinophilic Focus                   |                                                             X        X   |             
      Hepatodiaphragmatic Nodule           |                                                                   X  X   |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |                            2                                             |             
      Vacuolization Cytoplasmic            |                                        3        4                        |             
      Bile Duct, Hyperplasia               |    2        2                                                  2  1     1|             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +              +        +                  |             
      Inflammation, Chronic Active         |                                                       2                  |             
      Fat, Inflammation, Chronic Active    |                               3              3                           |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 1  1     2     1  2  2              1                       1  1     3   |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Cytomegaly                   |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                        3                                 |             
      Ulcer                                |                                                 3                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                               X                                          |             
      Hyperplasia                          |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                 1                        |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             
      Dentine, Dentine, Incisor, Incisor,  |                                                                          |             
           Necrosis, Multifocal, Multifocal|                                              1                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 6| 2| 4| 7| 1| 7| 7| 7| 7| 4| 7| 7| 6| 7| 1| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 8| 2| 3| 6| 5| 3| 8| 2| 3| 3| 3| 6| 3| 3| 6| 2| 8| 3| 3| 3| 4| 3| 3|             
                                           | 2| 2| 5| 9| 0| 0| 9| 2| 4| 9| 2| 2| 2| 3| 2| 2| 3| 9| 4| 2| 3| 3| 6| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
     0 PPM                                 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Dentine, Incisor, Necrosis, Focal    |          1                                                               |             
      Dentine, Incisor, Necrosis,          |                                                                          |             
          Multifocal                       | 1           1        3     1  1  1  1              1     1  1  1        1|             
      Peridontal Tissue, Incisor,          |                                                                          |             
          Inflammation, Necrotizing        |                                                                          |             
      Peridontal Tissue, Molar,            |                                                                          |             
          Inflammation, Suppurative        |                                                                          |             
      Peridontal Tissue, Molar, Lower,     |                                                                          |             
           Inflammation, Chronic,          |                                                                          |             
          Suppurative                      |                                                          2               |             
      Peridontal Tissue, Molar, Lower,     |                                                                          |             
           Inflammation, Chronic,          |                                                                          |             
          Suppurative                      | 2                    2           1     3                          4      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Chronic                | 1  2     2     1  1  1     1  1  1  1     2  2     1     2  1  1  1  2  1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Congestion                           |             4                                                            |             
      Degeneration, Cystic                 |                                           2        3                     |             
      Hyperplasia                          |          2           2        2     2        2                       2   |             
      Hypertrophy                          |                                                                          |             
      Vacuolization Cytoplasmic, Focal     | 2                          2                                             |             
      Bilateral, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                                                             2            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Pars Distalis, Congestion            |    3                 3     2              4                          3   |             
      Pars Distalis, Cyst                  | X                             X                    X     X        X      |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           | 2        3           3           2           2                       2  2|             
      Pars Intermedia, Cyst                |                      X                                                   |             
      Pars Intermedia, Hyperplasia         |                                                             2            |             
      Rathke's Cleft, Cyst                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |          2                                   2                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 6| 2| 4| 7| 1| 7| 7| 7| 7| 4| 7| 7| 6| 7| 1| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 8| 2| 3| 6| 5| 3| 8| 2| 3| 3| 3| 6| 3| 3| 6| 2| 8| 3| 3| 3| 4| 3| 3|             
                                           | 2| 2| 5| 9| 0| 0| 9| 2| 4| 9| 2| 2| 2| 3| 2| 2| 3| 9| 4| 2| 3| 3| 6| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
     0 PPM                                 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Glandular               |                                                    2                     |             
      Inflammation, Chronic Active         |                            2  2     2              2           2        2|             
      Duct, Cyst                           |                                  X                 X     X              X|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                                                          |             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cervix, Cyst                         |                                                                          |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |          3                                   3           3  2           2|             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                 +                        |             
      Exudate                              |                                                 X                        |             
      Prolapse                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Congestion              | 3                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                 3                        |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid, Nodular       |                                                                          |             
      Hyperplasia, Reticulum Cell          |    3                                                                     |             
      Infiltration Cellular, Lipocyte      |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  M  +  +|             
      Depletion Lymphoid                   | 2  3     4  3  3     2     3  2  2  3     4  2     4     2  2        2  2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2  2  2  3        2  2     2  2  4  3     3  3  3  3     3  3  3  2  3  3|             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Humerus, Osteosclerosis              |                                                          3              3|             
      Mandible, Fibrous Osteodystrophy     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 6| 2| 4| 7| 1| 7| 7| 7| 7| 4| 7| 7| 6| 7| 1| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 8| 2| 3| 6| 5| 3| 8| 2| 3| 3| 3| 6| 3| 3| 6| 2| 8| 3| 3| 3| 4| 3| 3|             
                                           | 2| 2| 5| 9| 0| 0| 9| 2| 4| 9| 2| 2| 2| 3| 2| 2| 3| 9| 4| 2| 3| 3| 6| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
     0 PPM                                 | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Thoracic, Vertebra, Fibrous          |                                                                          |             
          Osteodystrophy                   |                                                       1                  |             
      Thoracic, Vertebra, Osteosclerosis   |                                                          1              3|             
      Tibia, Fibrous Osteodystrophy        |                                                       1                  |             
      Tibia, Osteosclerosis                |                                                          2              3|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |    X                       X                                         X   |             
      Hemorrhage                           |                                                 3                        |             
      Hydrocephalus                        |                            2                                         2   |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Myelin, Degeneration                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Squamous                 |                2                                                         |             
      Mucosa, Inflammation, Acute          |                                        3                                 |             
      Mucosa, Inflammation, Chronic Active | 2  1           2              2              3                       2   |             
      Mucosa, Ulcer                        |                                        2                                 |             
      Sinus, Foreign Body                  | 3  1                                         3                           |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +        +           +     +                                +        +   |             
      Anterior Chamber, Hemorrhage         |                                                                          |             
      Lens, Cataract                       | 3        3           3     3                                3        3   |             
      Retina, Atrophy                      | 4        4           4     4                                4        4   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 1  2     3  1     1  1  2  3  1  1  1  2  2  1  2  2  1  2  1  1  2  2  4|             
      Cortex, Cyst                         |                                                                          |             
      Renal Tubule, Mineralization         |       2                                               3                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 1| 7| 6| 7| 7| 4| 7| 7| 6| 7| 4| 4| 4| 7| 7| 1| 7| 4| 1| 4|            |
                             DAY ON TEST   | 5| 3| 3| 3| 3| 8| 3| 2| 3| 1| 0| 1| 3| 8| 3| 5| 6| 6| 3| 3| 8| 3| 5| 8| 5|            |
                                           | 9| 3| 3| 3| 3| 4| 3| 0| 3| 0| 0| 9| 3| 3| 3| 9| 0| 0| 0| 0| 4| 0| 9| 5| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      A     |
     0 PPM                                 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Angiectasis                          |                                                                          |      1  1.0|
      Basophilic Focus                     | X     X  X  X     X     X  X        X     X           X  X     X        X|     55     |
      Clear Cell Focus                     |             X     X                       X           X        X         |     13     |
      Congestion                           |                                                                          |      1  3.0|
      Eosinophilic Focus                   |             X                                         X                  |      4     |
      Hepatodiaphragmatic Nodule           |                      X                             X                     |      8     |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Chronic Active         | 1  2                       2        1        2                    2     2|     23  1.8|
      Vacuolization Cytoplasmic            |                               2        3                                 |     11  2.6|
      Bile Duct, Hyperplasia               |          1              2        2        2                    2         |     25  2.0|
      Centrilobular, Necrosis              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Fat, Inflammation, Chronic Active    |                                                                          |      3  3.3|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Acinus, Atrophy                      |             2                    2                                       |     21  1.5|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Acinus, Cytomegaly                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Acanthosis                           |                               3                                          |      4  2.8|
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Hyperplasia                          |                      2                                                   |      1  2.0|
      Mineralization                       |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 1| 7| 6| 7| 7| 4| 7| 7| 6| 7| 4| 4| 4| 7| 7| 1| 7| 4| 1| 4|            |
                             DAY ON TEST   | 5| 3| 3| 3| 3| 8| 3| 2| 3| 1| 0| 1| 3| 8| 3| 5| 6| 6| 3| 3| 8| 3| 5| 8| 5|            |
                                           | 9| 3| 3| 3| 3| 4| 3| 0| 3| 0| 0| 9| 3| 3| 3| 9| 0| 0| 0| 0| 4| 0| 9| 5| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      A     |
     0 PPM                                 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                   +                                                      |   1        |
      Hyperplasia, Squamous                |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  98        |
      Dentine, Dentine, Incisor, Incisor,  |                                                                          |            |
           Necrosis, Multifocal, Multifocal|                                                                          |      1  1.0|
      Dentine, Incisor, Necrosis, Focal    |    1                                                                     |      5  1.0|
      Dentine, Incisor, Necrosis,          |                                                                          |            |
          Multifocal                       |             1        1  1        1  1                    1               |     54  1.1|
      Peridontal Tissue, Incisor,          |                                                                          |            |
          Inflammation, Necrotizing        |                                                                          |      1  3.0|
      Peridontal Tissue, Molar,            |                                                                          |            |
          Inflammation, Suppurative        |                                                                         4|      3  3.3|
      Peridontal Tissue, Molar, Lower,     |                                                                          |            |
           Inflammation, Chronic,          |                                                                          |            |
          Suppurative                      |                                                                          |      1  2.5|
      Peridontal Tissue, Molar, Lower,     |                                                                          |            |
           Inflammation, Chronic,          |                                                                          |            |
          Suppurative                      |    4  3     2                    3                                       |     19  2.7|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Degeneration, Chronic                | 1     1  2  1     2        2     1  2  3  2  2  1     3  2     2         |     69  1.6|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1     |
      Congestion                           |                                                                          |      1  4.0|
      Degeneration, Cystic                 |                                     2                                    |      5  2.4|
      Hyperplasia                          |          2                                                     2         |     17  2.0|
      Hypertrophy                          | 2  2                                                                     |      3  2.0|
      Vacuolization Cytoplasmic, Focal     |                   2  2                                   2               |      7  2.0|
      Bilateral, Hyperplasia               |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia                          |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 1| 7| 6| 7| 7| 4| 7| 7| 6| 7| 4| 4| 4| 7| 7| 1| 7| 4| 1| 4|            |
                             DAY ON TEST   | 5| 3| 3| 3| 3| 8| 3| 2| 3| 1| 0| 1| 3| 8| 3| 5| 6| 6| 3| 3| 8| 3| 5| 8| 5|            |
                                           | 9| 3| 3| 3| 3| 4| 3| 0| 3| 0| 0| 9| 3| 3| 3| 9| 0| 0| 0| 0| 4| 0| 9| 5| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      A     |
     0 PPM                                 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Congestion            |    4                                                     3     3         |     21  3.0|
      Pars Distalis, Cyst                  | X     X  X              X                    X        X                  |     20     |
      Pars Distalis, Hemorrhage            |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia           | 2                                   2        3  2  2  3        2         |     21  2.3|
      Pars Intermedia, Cyst                |                                                                          |      2     |
      Pars Intermedia, Hyperplasia         |                                                                          |      1  2.0|
      Rathke's Cleft, Cyst                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      C-Cell, Hyperplasia                  |                                           2                       2      |      9  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  98        |
      Hyperplasia, Glandular               |                                                                          |      4  2.0|
      Inflammation, Chronic Active         |    2              2                 1        1        2                  |     14  1.9|
      Duct, Cyst                           |                   X                                            X         |      8     |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Follicle, Cyst                       |                                                                          |      1     |
      Periovarian Tissue, Cyst             |                                                                X         |      2     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Cervix, Cyst                         |                                                                X         |      2     |
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       |                                              2                          2|     12  2.5|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   3        |
      Exudate                              |                                                                          |      1     |
      Prolapse                             |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  99        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Mediastinal, Congestion              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Fibrosis                             |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 1| 7| 6| 7| 7| 4| 7| 7| 6| 7| 4| 4| 4| 7| 7| 1| 7| 4| 1| 4|            |
                             DAY ON TEST   | 5| 3| 3| 3| 3| 8| 3| 2| 3| 1| 0| 1| 3| 8| 3| 5| 6| 6| 3| 3| 8| 3| 5| 8| 5|            |
                                           | 9| 3| 3| 3| 3| 4| 3| 0| 3| 0| 0| 9| 3| 3| 3| 9| 0| 0| 0| 0| 4| 0| 9| 5| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      A     |
     0 PPM                                 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid, Nodular       |                                                                          |      1  3.0|
      Hyperplasia, Reticulum Cell          |                                                                          |      2  2.5|
      Infiltration Cellular, Lipocyte      |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +|  90        |
      Depletion Lymphoid                   |    2  3  3  4     3  3  3  3     3  4     2           3                  |     62  2.8|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
      Hyperplasia, Cystic                  | 2  3  2  3  2     3  3  3  3     3  2  3  2           2  4  2  3  2     2|     81  2.8|
      Mineralization                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
      Ulcer                                |                            3                                             |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Humerus, Osteosclerosis              |                   3                                                      |      4  2.5|
      Mandible, Fibrous Osteodystrophy     |                                                                          |      1  2.0|
      Thoracic, Vertebra, Fibrous          |                                                                          |            |
          Osteodystrophy                   |                                                                          |      1  1.0|
      Thoracic, Vertebra, Osteosclerosis   |                   2                                                      |      5  2.0|
      Tibia, Fibrous Osteodystrophy        |                                                                          |      1  1.0|
      Tibia, Osteosclerosis                |                   2                                            2         |      6  2.2|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Compression                          |    X                                                     X               |      6     |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hydrocephalus                        |    2                                                     2               |      5  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                            +                                             |   1        |
      Myelin, Degeneration                 |                            3                                             |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Foreign Body                         |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |    2              2                                                      |      3  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 1| 7| 6| 7| 7| 4| 7| 7| 6| 7| 4| 4| 4| 7| 7| 1| 7| 4| 1| 4|            |
                             DAY ON TEST   | 5| 3| 3| 3| 3| 8| 3| 2| 3| 1| 0| 1| 3| 8| 3| 5| 6| 6| 3| 3| 8| 3| 5| 8| 5|            |
                                           | 9| 3| 3| 3| 3| 4| 3| 0| 3| 0| 0| 9| 3| 3| 3| 9| 0| 0| 0| 0| 4| 0| 9| 5| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      A     |
     0 PPM                                 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                                              2                           |      1  2.0|
      Metaplasia, Squamous                 |                                                                          |      1  2.0|
      Mucosa, Inflammation, Acute          |                                                                          |      2  2.5|
      Mucosa, Inflammation, Chronic Active |                                           2                              |     12  2.3|
      Mucosa, Ulcer                        |                                                                          |      2  2.0|
      Sinus, Foreign Body                  |                                                                          |      6  2.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                   +     +  +                       +                     |  21        |
      Anterior Chamber, Hemorrhage         |                                                                          |      1  3.0|
      Lens, Cataract                       |                   3     3  3                                             |     19  3.1|
      Retina, Atrophy                      |                   4     4  4                                             |     19  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Nephropathy, Chronic                 | 2  3  2  1  3     3  2  1  2     1  2  1  3  1  2  1  2  1     3  2      |     84  1.9|
      Cortex, Cyst                         |                                                                          |      1     |
      Renal Tubule, Mineralization         |                2                                            2        1   |      9  1.9|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 4| 5| 7| 6| 7| 6| 7| 7| 7| 6| 5| 6| 7| 5| 7| 6| 6| 7| 5| 5| 6| 6| 5|             
                             DAY ON TEST   | 3| 3| 1| 7| 1| 4| 0| 6| 3| 3| 3| 1| 6| 0| 3| 1| 3| 7| 2| 3| 9| 8| 7| 2| 6|             
                                           | 8| 0| 5| 9| 6| 1| 5| 1| 0| 0| 0| 4| 1| 9| 1| 5| 1| 7| 0| 1| 9| 4| 0| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    SPECIAL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
      Basophilic Focus                     |             X  X  X  X           X                                   X   |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |                                                                      X   |             
      Hepatodiaphragmatic Nodule           |                      X                       X                           |             
      Inflammation, Chronic Active         |       1        2     3           2                 3  2                  |             
      Vacuolization Cytoplasmic            |                                        4                    4     3      |             
      Bile Duct, Hyperplasia               | 1              2     2                 2                    2  2  4  2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
      Acinus, Atrophy                      |                      2              2              2        1  1         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
      Acanthosis                           |                                        3                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
      Necrosis                             |                                                                          |             
      Ulcer                                |                                        2                                 |             
                                            __________________________________________________________________________|             
   Tooth                                   | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
      Dentine, Incisor, Dysplasia          |          1                                                               |             
      Dentine, Incisor, Necrosis,          |                                                                          |             
          Multifocal                       |             1  1                    1  1     1     1  1           1  1  1|             
      Peridontal Tissue, Molar, Lower,     |                                                                          |             
           Inflammation, Chronic,          |                                                                          |             
          Suppurative                      |          3  3  2                                                         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
      Degeneration, Chronic                | 1        1     1  1  3              2              2        1  1     1   |             
      Thrombosis                           |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  M  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
      Hyperplasia                          |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 4| 5| 7| 6| 7| 6| 7| 7| 7| 6| 5| 6| 7| 5| 7| 6| 6| 7| 5| 5| 6| 6| 5|             
                             DAY ON TEST   | 3| 3| 1| 7| 1| 4| 0| 6| 3| 3| 3| 1| 6| 0| 3| 1| 3| 7| 2| 3| 9| 8| 7| 2| 6|             
                                           | 8| 0| 5| 9| 6| 1| 5| 1| 0| 0| 0| 4| 1| 9| 1| 5| 1| 7| 0| 1| 9| 4| 0| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    SPECIAL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hypertrophy                          |             2                                                            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
      Pars Distalis, Congestion            |                                                                          |             
      Pars Distalis, Cyst                  |          X                                                        X  X   |             
      Pars Distalis, Hemorrhage            |             3                                                            |             
      Pars Distalis, Hyperplasia           |                                        2     2     3                 2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Cyst                       |                                              X                           |             
      Follicular Cell, Hyperplasia         |          1                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
      Hyperplasia, Glandular               |                                                                          |             
      Inflammation, Chronic Active         |                                                                1  1      |             
                                            __________________________________________________________________________|             
   Ovary                                   | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
      Follicle, Cyst                       |                                                             X            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
      Cervix, Cyst                         |                      X                                                   |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |          2     2                                            2            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
      Mediastinal, Angiectasis             |                      3                                                   |             
      Renal, Angiectasis                   |                                  2                                       |             
      Renal, Pigmentation, Hemosiderin     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  M  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
      Fibrosis                             |                                                                   3      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +  +  +  M  +  +           +  +  I     +     +  +     +  +  +  +  +|             
      Depletion Lymphoid                   |          2        2                                   3           2  3   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
      Hyperplasia, Cystic                  |          3  2  4  2  2           2     3     2     3  3     3  1  3  3  3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 4| 5| 7| 6| 7| 6| 7| 7| 7| 6| 5| 6| 7| 5| 7| 6| 6| 7| 5| 5| 6| 6| 5|             
                             DAY ON TEST   | 3| 3| 1| 7| 1| 4| 0| 6| 3| 3| 3| 1| 6| 0| 3| 1| 3| 7| 2| 3| 9| 8| 7| 2| 6|             
                                           | 8| 0| 5| 9| 6| 1| 5| 1| 0| 0| 0| 4| 1| 9| 1| 5| 1| 7| 0| 1| 9| 4| 0| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    SPECIAL                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
      Humerus, Osteosclerosis              |                                        2     3                    1      |             
      Maxilla, Fibrous Osteodystrophy      |                                                    1                     |             
      Thoracic, Vertebra, Osteosclerosis   |                                              3                           |             
      Tibia, Osteosclerosis                |                                        1     4                           |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
      Compression                          |                                                       X                  |             
      Hydrocephalus                        |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                      2                                                   |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
      Mucosa, Inflammation, Acute          |                                                                         2|             
      Mucosa, Inflammation, Chronic Active |                                                             2            |             
      Sinus, Foreign Body                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +  +                                                      |             
      Lens, Cataract                       |                3  3                                                      |             
      Retina, Atrophy                      |                4  4                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
      Nephropathy, Chronic                 |       1  2  3  2  2  2           2     2     2     1  2     2  1  1  1  1|             
      Cortex, Cyst                         |                                                                         X|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +  +  +  +           +  +  +     +     +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 6| 7| 6| 7| 6| 3| 7| 7| 7| 7| 4| 7| 4| 7| 5| 7| 4| 3| 6| 7| 7|            |
                             DAY ON TEST   | 4| 3| 3| 4| 3| 3| 9| 3| 3| 7| 3| 3| 3| 3| 5| 3| 0| 1| 5| 2| 6| 2| 4| 3| 3|            |
                                           | 3| 1| 1| 6| 3| 2| 8| 2| 2| 9| 2| 2| 3| 3| 1| 3| 2| 0| 7| 6| 3| 0| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    SPECIAL                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +        +  +     +     +  +              +     +  M  +  +  +  +  +      |  31        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  32        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  32        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  32        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  32        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  32        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  32        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  32        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  32        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  32        |
      Basophilic Focus                     |          X        X        X              X        X     X        X      |     13     |
      Clear Cell Focus                     |                                                          X               |      1     |
      Eosinophilic Focus                   |                                                                          |      1     |
      Hepatodiaphragmatic Nodule           |          X                                            X  X               |      5     |
      Inflammation, Chronic Active         |          2                                      1  2  2        2         |     11  2.0|
      Vacuolization Cytoplasmic            |             4           4                                      3         |      6  3.7|
      Bile Duct, Hyperplasia               | 1           2           3                                   1            |     12  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +                                                            |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  32        |
      Acinus, Atrophy                      |                                                             2            |      6  1.7|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  32        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  32        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  32        |
      Acanthosis                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  32        |
      Necrosis                             |             2           2                                                |      2  2.0|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +        +  +     +     +  +              +     +  +  +  +  +  +  I      |  31        |
      Dentine, Incisor, Dysplasia          |                         1                                                |      2  1.0|
      Dentine, Incisor, Necrosis,          |                                                                          |            |
          Multifocal                       | 1        1  1     1     1                          1                     |     16  1.0|
      Peridontal Tissue, Molar, Lower,     |                                                                          |            |
           Inflammation, Chronic,          |                                                                          |            |
          Suppurative                      |          3                                               3               |      5  2.8|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  32        |
      Degeneration, Chronic                | 1                 1                       1     1  1  2  2        3      |     18  1.4|
      Thrombosis                           |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 6| 7| 6| 7| 6| 3| 7| 7| 7| 7| 4| 7| 4| 7| 5| 7| 4| 3| 6| 7| 7|            |
                             DAY ON TEST   | 4| 3| 3| 4| 3| 3| 9| 3| 3| 7| 3| 3| 3| 3| 5| 3| 0| 1| 5| 2| 6| 2| 4| 3| 3|            |
                                           | 3| 1| 1| 6| 3| 2| 8| 2| 2| 9| 2| 2| 3| 3| 1| 3| 2| 0| 7| 6| 3| 0| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    SPECIAL                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  31        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  32        |
      Hyperplasia                          |                                                          2               |      2  2.0|
      Hypertrophy                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  32        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  32        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  32        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  32        |
      Pars Distalis, Congestion            |                   2                                                      |      1  2.0|
      Pars Distalis, Cyst                  |          X              X                 X                              |      6     |
      Pars Distalis, Hemorrhage            |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia           |                                                       2  2  2            |      7  2.1|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  32        |
      C-Cell, Hyperplasia                  |          2                                                               |      1  2.0|
      Follicle, Cyst                       |                                                                          |      1     |
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  32        |
      Hyperplasia, Glandular               |                                                                   3      |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  32        |
      Follicle, Cyst                       |                                                       X                  |      2     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  32        |
      Cervix, Cyst                         |                                                                          |      1     |
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       |                                           3                              |      4  2.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  32        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  32        |
      Mediastinal, Angiectasis             |                                                                          |      1  3.0|
      Renal, Angiectasis                   |                                                                          |      1  2.0|
      Renal, Pigmentation, Hemosiderin     |                                                             2            |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 6| 7| 6| 7| 6| 3| 7| 7| 7| 7| 4| 7| 4| 7| 5| 7| 4| 3| 6| 7| 7|            |
                             DAY ON TEST   | 4| 3| 3| 4| 3| 3| 9| 3| 3| 7| 3| 3| 3| 3| 5| 3| 0| 1| 5| 2| 6| 2| 4| 3| 3|            |
                                           | 3| 1| 1| 6| 3| 2| 8| 2| 2| 9| 2| 2| 3| 3| 1| 3| 2| 0| 7| 6| 3| 0| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    SPECIAL                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  32        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  31        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  32        |
      Fibrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +        +  +     +     +  +              +     +  M  +  +  +  +  +      |  29        |
      Depletion Lymphoid                   |          2  3     2     3                                2               |     10  2.4|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  31        |
      Hyperplasia, Cystic                  | 1           3     3     3  2                       3  2  2        3      |     24  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  32        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  32        |
      Humerus, Osteosclerosis              |             3                                                            |      4  2.3|
      Maxilla, Fibrous Osteodystrophy      |                                                                          |      1  1.0|
      Thoracic, Vertebra, Osteosclerosis   |                                                                          |      1  3.0|
      Tibia, Osteosclerosis                |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  32        |
      Compression                          |                                                                X         |      2     |
      Hydrocephalus                        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  32        |
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  32        |
      Mucosa, Inflammation, Acute          |                                                                          |      1  2.0|
      Mucosa, Inflammation, Chronic Active | 2                                               2                 2      |      4  2.0|
      Sinus, Foreign Body                  | 3                                                                 2      |      2  2.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  32        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +                                                  +  +      |   5        |
      Lens, Cataract                       |             3                                                  3  3      |      5  3.0|
      Retina, Atrophy                      |             4                                                  4  4      |      5  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 6| 7| 6| 7| 6| 3| 7| 7| 7| 7| 4| 7| 4| 7| 5| 7| 4| 3| 6| 7| 7|            |
                             DAY ON TEST   | 4| 3| 3| 4| 3| 3| 9| 3| 3| 7| 3| 3| 3| 3| 5| 3| 0| 1| 5| 2| 6| 2| 4| 3| 3|            |
                                           | 3| 1| 1| 6| 3| 2| 8| 2| 2| 9| 2| 2| 3| 3| 1| 3| 2| 0| 7| 6| 3| 0| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      A     |
    SPECIAL                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  32        |
      Nephropathy, Chronic                 | 1                 2     1  2              1        2  1  2  2  1  1      |     27  1.6|
      Cortex, Cyst                         |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +        +  +     +     +  +              +     +  +  +  +  +  +  +      |  32        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 6| 4| 7| 7| 1| 4| 7| 7| 4| 1| 7| 7| 7| 1| 7| 1| 4| 5| 7|             
                             DAY ON TEST   | 6| 3| 3| 6| 3| 3| 1| 5| 2| 3| 8| 5| 3| 0| 5| 8| 2| 2| 2| 8| 1| 8| 5| 8| 3|             
                                           | 0| 0| 0| 0| 0| 0| 8| 9| 9| 0| 4| 9| 1| 9| 9| 5| 9| 9| 9| 5| 8| 4| 1| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
     25 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     M     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     M     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     M     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     M     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     +     +  +  +|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     +     +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     +     +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X     X  X              X  X                 X|             
      Clear Cell Focus                     |    X        X  X                                X                        |             
      Congestion                           |                                                                          |             
      Eosinophilic Focus                   |       X                 X  X        X                 X                  |             
      Hepatodiaphragmatic Nodule           |       X  X                                      X                 X      |             
      Hyperplasia                          |                   3                                                      |             
      Inflammation, Chronic Active         |          2           2  2                       3  2                     |             
      Vacuolization Cytoplasmic            |                                                             2           2|             
      Bile Duct, Hyperplasia               |                                  1                          3     2      |             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                                    |             
      Fat, Inflammation, Chronic Active    |                                     2                                    |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     +     +  +  +|             
      Acinus, Atrophy                      |       1              1              2  1                                 |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     +     +  +  +|             
      Acanthosis                           |                                                                         3|             
      Ulcer                                |                                                                         3|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     +     +  +  +|             
      Erosion                              |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            |                                                             2            |             
      Pigmentation                         |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dentine, Incisor, Dysplasia          |             2                                                            |             
      Dentine, Incisor, Necrosis,          |                                                                          |             
          Multifocal                       |       1     1  1           1        1  1           1  1     1            |             
      Peridontal Tissue, Incisor, Lower,   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 6| 4| 7| 7| 1| 4| 7| 7| 4| 1| 7| 7| 7| 1| 7| 1| 4| 5| 7|             
                             DAY ON TEST   | 6| 3| 3| 6| 3| 3| 1| 5| 2| 3| 8| 5| 3| 0| 5| 8| 2| 2| 2| 8| 1| 8| 5| 8| 3|             
                                           | 0| 0| 0| 0| 0| 0| 8| 9| 9| 0| 4| 9| 1| 9| 9| 5| 9| 9| 9| 5| 8| 4| 1| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
     25 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
           Inflammation, Chronic,          |                                                                          |             
          Suppurative                      |                                                                          |             
      Peridontal Tissue, Molar,            |                                                                          |             
          Inflammation, Suppurative        |          2                                                               |             
      Peridontal Tissue, Molar, Lower,     |                                                                          |             
           Inflammation, Chronic,          |                                                                          |             
          Suppurative                      |    3                                   3                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     +     +  +  +|             
      Degeneration, Chronic                | 1  1  2     1  1        1  2        2           2  1  1           1  1   |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     +     +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     +     +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Angiectasis                          |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia                          | 2  2                       2                                         2   |             
      Hypertrophy                          |                                                    2                     |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     +     +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |                                     3                       3            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     +     +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     +     +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     +     +  +  +|             
      Pars Distalis, Congestion            |    2  3                    4                          2                 3|             
      Pars Distalis, Cyst                  |                                     X     X     X  X                     |             
      Pars Distalis, Hemorrhage            |                                                             2            |             
      Pars Distalis, Hyperplasia           |    2                             2     2                    2     2      |             
      Pars Intermedia, Congestion          |                                     3                                    |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     +     +  +  +|             
      C-Cell, Hyperplasia                  |       1                    1                    1                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     M     +  +  +|             
      Hyperplasia, Glandular               |    2                    2                       2  2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 6| 4| 7| 7| 1| 4| 7| 7| 4| 1| 7| 7| 7| 1| 7| 1| 4| 5| 7|             
                             DAY ON TEST   | 6| 3| 3| 6| 3| 3| 1| 5| 2| 3| 8| 5| 3| 0| 5| 8| 2| 2| 2| 8| 1| 8| 5| 8| 3|             
                                           | 0| 0| 0| 0| 0| 0| 8| 9| 9| 0| 4| 9| 1| 9| 9| 5| 9| 9| 9| 5| 8| 4| 1| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
     25 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |       1  2                          1                                    |             
      Duct, Cyst                           |       X                                                                  |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     +     +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Periovarian Tissue, Cyst             |             X                                   X                       X|             
      Periovarian Tissue, Hemorrhage       |                                                 3                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     +     +  +  +|             
      Cervix, Cyst                         |                                                                          |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |                                           2     2                        |             
                                            __________________________________________________________________________|             
   Vagina                                  |                   +                                                      |             
      Exudate                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     +     +  +  +|             
      Femoral, Myelofibrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     +     +  +  +|             
      Mediastinal, Congestion              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     +     +  +  +|             
      Congestion                           |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     +     +  +  +|             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     +     +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Reticulum Cell          |    3                                                                     |             
      Capsule, Fibrosis                    |                                                                          |             
      Red Pulp, Atrophy                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     +     +  +  +|             
      Depletion Lymphoid                   |       3     3  2        3  4        3  2        3  2  4              2  3|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     +     +  +  +|             
      Hyperplasia, Cystic                  | 2  2  3     2  3        2  4     1  2  3  2     3  2  3     3        3  3|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     +     +  +  +|             
      Ulcer                                |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Humerus, Fibrous Osteodystrophy      |                                     1                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 7| 6| 4| 7| 7| 1| 4| 7| 7| 4| 1| 7| 7| 7| 1| 7| 1| 4| 5| 7|             
                             DAY ON TEST   | 6| 3| 3| 6| 3| 3| 1| 5| 2| 3| 8| 5| 3| 0| 5| 8| 2| 2| 2| 8| 1| 8| 5| 8| 3|             
                                           | 0| 0| 0| 0| 0| 0| 8| 9| 9| 0| 4| 9| 1| 9| 9| 5| 9| 9| 9| 5| 8| 4| 1| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
     25 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Humerus, Osteosclerosis              |                                                                          |             
      Thoracic, Vertebra, Osteosclerosis   |                                                                          |             
      Tibia, Osteosclerosis                |          1              3                                                |             
      Vertebra, Osteosclerosis             |          1                                                               |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     +     +  +  +|             
      Compression                          |                                                                      X   |             
      Hydrocephalus                        |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     +     +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                   4                                                      |             
      Alveolar Epithelium, Hyperplasia     |                                                                         2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     +     +  +  +|             
      Inflammation, Chronic Active         |                                           2                              |             
      Metaplasia, Squamous                 |                                           2                       2      |             
      Mucosa, Inflammation, Chronic Active |                            3                          2           2      |             
      Sinus, Foreign Body                  |                            3                          2                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +  +                       +                     |             
      Lens, Cataract                       |                         3  3                       3                     |             
      Retina, Atrophy                      |                         4  4                       4                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     +     +  +  +|             
      Inflammation, Acute, Focal           |                                                                          |             
      Nephropathy, Chronic                 | 1  2  2  2  1  3     2  3  2     1  2  2  1     3  3  3     1     3  2  4|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +     M     +  +  +|             
      Dilatation                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 1| 1| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 8| 8| 2| 1| 3| 7| 5| 3| 2| 3| 3| 6| 1| 1| 1| 3| 6| 2| 5| 3| 7| 3|             
                                           | 1| 1| 9| 4| 4| 9| 5| 1| 7| 9| 1| 9| 2| 2| 0| 9| 9| 9| 2| 5| 9| 9| 2| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
     25 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                      2   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                      2                                                   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |    X           X     X        X  X  X  X        X     X     X     X     X|             
      Clear Cell Focus                     |                                  X  X  X              X                  |             
      Congestion                           |                                  2                                       |             
      Eosinophilic Focus                   |                                                                         X|             
      Hepatodiaphragmatic Nodule           |                                                    X     X               |             
      Hyperplasia                          |                                                                      2   |             
      Inflammation, Chronic Active         |                               1        2     1  2  2        2     2      |             
      Vacuolization Cytoplasmic            |                   3  3  3                                            3   |             
      Bile Duct, Hyperplasia               |    2  3                    2        2                    1           2   |             
      Centrilobular, Necrosis              |                   3                                                      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +                                                |             
      Fat, Inflammation, Chronic Active    |                         3                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                2           1        2                 2                  |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                         3                                                |             
      Ulcer                                |       3                                                                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Pigmentation                         |                   2                                                      |             
      Ulcer                                |                   2                                                      |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dentine, Incisor, Dysplasia          |                                  1                             1     2   |             
      Dentine, Incisor, Necrosis,          |                                                                          |             
          Multifocal                       | 1  1  1        1     2  2        1  1  1     1  1     1  1  1     1     1|             
      Peridontal Tissue, Incisor, Lower,   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 1| 1| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 8| 8| 2| 1| 3| 7| 5| 3| 2| 3| 3| 6| 1| 1| 1| 3| 6| 2| 5| 3| 7| 3|             
                                           | 1| 1| 9| 4| 4| 9| 5| 1| 7| 9| 1| 9| 2| 2| 0| 9| 9| 9| 2| 5| 9| 9| 2| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
     25 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
           Inflammation, Chronic,          |                                                                          |             
          Suppurative                      |                                                          3               |             
      Peridontal Tissue, Molar,            |                                                                          |             
          Inflammation, Suppurative        |                                                                          |             
      Peridontal Tissue, Molar, Lower,     |                                                                          |             
           Inflammation, Chronic,          |                                                                          |             
          Suppurative                      |    4           2                       2                                2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Chronic                | 1  2           1  1  3  2  1  1  1  1  1  1     2     1  1  1  1  2  2  1|             
      Thrombosis                           |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Angiectasis                          |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia                          |    2           2                       2                             3  1|             
      Hypertrophy                          |                               2                       2     1            |             
      Necrosis                             |                   3                                                      |             
      Vacuolization Cytoplasmic, Focal     |                      3                                                   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |                                        2                                 |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Congestion            |                3                    4              3                     |             
      Pars Distalis, Cyst                  | X  X           X        X  X     X     X     X     X  X           X  X  X|             
      Pars Distalis, Hemorrhage            |                                                       3                  |             
      Pars Distalis, Hyperplasia           |                   2                          2  2                        |             
      Pars Intermedia, Congestion          |                                                                          |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    2                 2                             2                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Glandular               |                                     3           2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 1| 1| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 8| 8| 2| 1| 3| 7| 5| 3| 2| 3| 3| 6| 1| 1| 1| 3| 6| 2| 5| 3| 7| 3|             
                                           | 1| 1| 9| 4| 4| 9| 5| 1| 7| 9| 1| 9| 2| 2| 0| 9| 9| 9| 2| 5| 9| 9| 2| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
     25 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |       2                       1           2                 2            |             
      Duct, Cyst                           |                               X                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Periovarian Tissue, Cyst             |                                                                         X|             
      Periovarian Tissue, Hemorrhage       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cervix, Cyst                         |                                                                          |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       | 2  3                             2                                       |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Exudate                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Myelofibrosis               |                   3                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Congestion              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                3              2                                          |             
      Necrosis                             |                   3                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |                   2                                                      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                   3                                                      |             
      Fibrosis                             |    2                                                                     |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
      Capsule, Fibrosis                    |                                                                          |             
      Red Pulp, Atrophy                    |                   4                                                      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   | 3  2           3  4  3  3     3  3  3  2     2  2  2  3     4  2  2     3|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |    3  4        3  3     4  2  3  3  3  4     2  3  3  3  2  3  3  3  3  3|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                 3                        |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                 4                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Humerus, Fibrous Osteodystrophy      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 1| 1| 7| 7| 6| 6| 4| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 3| 8| 8| 2| 1| 3| 7| 5| 3| 2| 3| 3| 6| 1| 1| 1| 3| 6| 2| 5| 3| 7| 3|             
                                           | 1| 1| 9| 4| 4| 9| 5| 1| 7| 9| 1| 9| 2| 2| 0| 9| 9| 9| 2| 5| 9| 9| 2| 7| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
     25 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Humerus, Osteosclerosis              |       3           3                                         1        1   |             
      Thoracic, Vertebra, Osteosclerosis   |       1           3           3                                   1  2   |             
      Tibia, Osteosclerosis                |       1        2  3           3                                   2  2   |             
      Vertebra, Osteosclerosis             |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                      X              X                          X         |             
      Hydrocephalus                        |                      3              2                                    |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                 2     1                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Squamous                 |                                                                          |             
      Mucosa, Inflammation, Chronic Active |                                  3           2                           |             
      Sinus, Foreign Body                  |                                  3                                       |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +     +  +                                                |             
      Lens, Cataract                       |                3     3  3                                                |             
      Retina, Atrophy                      |                4     4  4                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Focal           |                                                                      3   |             
      Nephropathy, Chronic                 | 3  3  2        2  1  4  3  3  3  2  3  1  1  2  1  2  1  2  3  2  1  1  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 4| 1| 6| 7| 7| 1| 1| 7| 7| 7| 7| 7| 4| 7| 1| 4| 7|              |            |
                             DAY ON TEST   | 2| 2| 3| 6| 8| 9| 2| 3| 8| 8| 2| 0| 0| 3| 3| 5| 3| 8| 5| 3|              |            |
                                           | 9| 0| 2| 0| 5| 6| 9| 3| 5| 5| 9| 2| 4| 3| 3| 9| 3| 5| 9| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
     25 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  60        |
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  60        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  60        |
      Angiectasis                          |                               2                                          |      1  2.0|
      Basophilic Focus                     | X     X           X  X        X  X     X  X  X        X  X               |     38     |
      Clear Cell Focus                     |                                                                          |      8     |
      Congestion                           |                                                                          |      1  2.0|
      Eosinophilic Focus                   |                                                                          |      6     |
      Hepatodiaphragmatic Nodule           |                X                    X                                    |      8     |
      Hyperplasia                          |                                                                          |      2  2.5|
      Inflammation, Chronic Active         |       2  2        2                             4     1                  |     17  2.0|
      Vacuolization Cytoplasmic            |    4                 4                                                   |      8  3.0|
      Bile Duct, Hyperplasia               | 2  3     1                          3        2                           |     14  2.1|
      Centrilobular, Necrosis              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                     +                                    |   3        |
      Fat, Inflammation, Chronic Active    |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  60        |
      Acinus, Atrophy                      |    3                                                  1                  |     10  1.6|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                        +                                 |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  60        |
      Acanthosis                           |    3                                                                     |      3  3.0|
      Ulcer                                |                                     3                                    |      3  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  60        |
      Erosion                              |                      2                                                   |      1  2.0|
      Necrosis                             |                                  2                                       |      1  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 4| 1| 6| 7| 7| 1| 1| 7| 7| 7| 7| 7| 4| 7| 1| 4| 7|              |            |
                             DAY ON TEST   | 2| 2| 3| 6| 8| 9| 2| 3| 8| 8| 2| 0| 0| 3| 3| 5| 3| 8| 5| 3|              |            |
                                           | 9| 0| 2| 0| 5| 6| 9| 3| 5| 5| 9| 2| 4| 3| 3| 9| 3| 5| 9| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
     25 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Dentine, Incisor, Dysplasia          |    1           1  1  1                                                   |      8  1.3|
      Dentine, Incisor, Necrosis,          |                                                                          |            |
          Multifocal                       | 1  1           1     1           1  1     1     1        1               |     34  1.1|
      Peridontal Tissue, Incisor, Lower,   |                                                                          |            |
           Inflammation, Chronic,          |                                                                          |            |
          Suppurative                      |                                                                          |      1  3.0|
      Peridontal Tissue, Molar,            |                                                                          |            |
          Inflammation, Suppurative        |                                              3                           |      2  2.5|
      Peridontal Tissue, Molar, Lower,     |                                                                          |            |
           Inflammation, Chronic,          |                                                                          |            |
          Suppurative                      |                      2                                                   |      7  2.6|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  60        |
      Degeneration, Chronic                | 1  2  1        3  2           2  2  1  2  2  1  2        2               |     46  1.5|
      Thrombosis                           |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  60        |
      Accessory Adrenal Cortical Nodule    |                X                                                         |      1     |
      Angiectasis                          |          3                                                               |      1  3.0|
      Degeneration, Cystic                 |                                     2                                    |      1  2.0|
      Hyperplasia                          |                2              2                 2        2               |     13  2.0|
      Hypertrophy                          |    2                                                                     |      5  1.8|
      Necrosis                             |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +        +  +        +  +  +  +  +  +  +     +  +               |  59        |
      Angiectasis                          |          3                                                               |      1  3.0|
      Hyperplasia                          |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +     +  +  +        +  M  M  +  +  +  +     +  +               |  56        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  60        |
      Pars Distalis, Congestion            | 3                                      2  4     4                        |     12  3.1|
      Pars Distalis, Cyst                  | X  X                 X                 X     X        X                  |     23     |
      Pars Distalis, Hemorrhage            |                                                                          |      2  2.5|
      Pars Distalis, Hyperplasia           |                   3           2        2     2           2               |     13  2.1|
      Pars Intermedia, Congestion          |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 4| 1| 6| 7| 7| 1| 1| 7| 7| 7| 7| 7| 4| 7| 1| 4| 7|              |            |
                             DAY ON TEST   | 2| 2| 3| 6| 8| 9| 2| 3| 8| 8| 2| 0| 0| 3| 3| 5| 3| 8| 5| 3|              |            |
                                           | 9| 0| 2| 0| 5| 6| 9| 3| 5| 5| 9| 2| 4| 3| 3| 9| 3| 5| 9| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
     25 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Intermedia, Cyst                |                      X                                                   |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  60        |
      C-Cell, Hyperplasia                  |                                                                          |      6  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  M  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  58        |
      Hyperplasia, Glandular               | 2                                                                        |      7  2.1|
      Inflammation, Chronic Active         |                2     1                                   1               |     10  1.5|
      Duct, Cyst                           |                   X                                                      |      3     |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  60        |
      Infiltration Cellular, Lymphocyte    |                                        3                                 |      1  3.0|
      Periovarian Tissue, Cyst             |                                     X  X                                 |      6     |
      Periovarian Tissue, Hemorrhage       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  60        |
      Cervix, Cyst                         |       X                                                                  |      1     |
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       | 2  3              2  1                    2  3        2  2               |     13  2.2|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                     +                                    |   2        |
      Exudate                              |                                     X                                    |      1     |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  60        |
      Femoral, Myelofibrosis               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  60        |
      Mediastinal, Congestion              |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  60        |
      Congestion                           |                3                                                         |      3  2.7|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  60        |
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  60        |
      Depletion Lymphoid                   |                                                                          |      1  3.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                  4                                       |      1  4.0|
      Hyperplasia, Reticulum Cell          |                                                                          |      1  3.0|
      Capsule, Fibrosis                    |    2                                                                     |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 4| 1| 6| 7| 7| 1| 1| 7| 7| 7| 7| 7| 4| 7| 1| 4| 7|              |            |
                             DAY ON TEST   | 2| 2| 3| 6| 8| 9| 2| 3| 8| 8| 2| 0| 0| 3| 3| 5| 3| 8| 5| 3|              |            |
                                           | 9| 0| 2| 0| 5| 6| 9| 3| 5| 5| 9| 2| 4| 3| 3| 9| 3| 5| 9| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
     25 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Red Pulp, Atrophy                    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +     +  +  +        +  +  +  +  +  +  M     +  +               |  58        |
      Depletion Lymphoid                   | 3  3  4        2  2  4        4  3  4  3  3              3               |     42  2.9|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  60        |
      Hyperplasia, Cystic                  | 3  3  3        3  3  4        3  2  2  3  4  3  4        2               |     51  2.8|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  60        |
      Ulcer                                |                                                                          |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Humerus, Fibrous Osteodystrophy      |                                                                          |      1  1.0|
      Humerus, Osteosclerosis              |    1                                                                     |      5  1.8|
      Thoracic, Vertebra, Osteosclerosis   |       1                                1                                 |      7  1.7|
      Tibia, Osteosclerosis                |    2              2                    2                                 |     11  2.1|
      Vertebra, Osteosclerosis             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                     +                                    |   1        |
      Necrosis                             |                                     4                                    |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  60        |
      Compression                          |                                                                          |      4     |
      Hydrocephalus                        |                                                                          |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  60        |
      Inflammation, Chronic Active         |                      2                                                   |      1  2.0|
      Mineralization                       |                                                                          |      1  4.0|
      Alveolar Epithelium, Hyperplasia     |                      2                                                   |      4  1.8|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  60        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Metaplasia, Squamous                 |                                                                          |      2  2.0|
      Mucosa, Inflammation, Chronic Active |                               3        2                                 |      7  2.4|
      Sinus, Foreign Body                  |                               3        2                                 |      5  2.6|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 4| 1| 6| 7| 7| 1| 1| 7| 7| 7| 7| 7| 4| 7| 1| 4| 7|              |            |
                             DAY ON TEST   | 2| 2| 3| 6| 8| 9| 2| 3| 8| 8| 2| 0| 0| 3| 3| 5| 3| 8| 5| 3|              |            |
                                           | 9| 0| 2| 0| 5| 6| 9| 3| 5| 5| 9| 2| 4| 3| 3| 9| 3| 5| 9| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
     25 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +     +  +                                +                              |  10        |
      Lens, Cataract                       | 3     3  2                                3                              |     10  2.9|
      Retina, Atrophy                      | 4     4  4                                4                              |     10  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  60        |
      Inflammation, Acute, Focal           |                                                                          |      1  3.0|
      Nephropathy, Chronic                 | 2  1  2  1     2  2  3        2  1     2  2  1  3     1  2               |     58  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +     +  +  +        +  +  +  +  +  +  +     +  +               |  59        |
      Dilatation                           |    4                                                                     |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 6| 4| 6| 6| 4| 7| 1| 5| 7| 7| 7| 4| 7| 4| 1| 7| 1| 7| 1| 7| 4| 5| 7|             
                             DAY ON TEST   | 8| 6| 6| 6| 6| 4| 6| 3| 8| 6| 3| 3| 3| 5| 3| 6| 8| 3| 8| 3| 8| 3| 6| 6| 3|             
                                           | 4| 0| 2| 0| 3| 7| 0| 1| 5| 8| 1| 1| 1| 9| 0| 0| 4| 1| 5| 1| 4| 0| 0| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
     100 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
      Basophilic Focus                     |       X        X     X        X     X     X        X     X        X     X|             
      Clear Cell Focus                     |                               X                                          |             
      Congestion                           |       2              2                                                   |             
      Eosinophilic Focus                   |                                                          X               |             
      Hepatodiaphragmatic Nodule           |                   X           X  X  X        X                           |             
      Hepatodiaphragmatic Nodule, Multiple |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |    2  2           3                          1     2              1     2|             
      Mixed Cell Focus                     |                                                                          |             
      Vacuolization Cytoplasmic            |             3                    3                                   2   |             
      Bile Duct, Hyperplasia               |                                              2                    2     2|             
      Centrilobular, Necrosis              |                                  3                                       |             
      Hepatocyte, Degeneration, Cystic     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                                                  +         |             
      Fat, Congestion, Acute               |                                                                3         |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
      Acinus, Atrophy                      |       2                    2                                             |             
      Acinus, Cytomegaly, Focal            |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                           +                              |             
      Hyperplasia, Squamous                |                                           2                              |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
      Acinus, Atrophy                      |                                  2                                       |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
      Acanthosis                           |                                  2                                       |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |             3                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
      Necrosis                             |             2                                                            |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 6| 4| 6| 6| 4| 7| 1| 5| 7| 7| 7| 4| 7| 4| 1| 7| 1| 7| 1| 7| 4| 5| 7|             
                             DAY ON TEST   | 8| 6| 6| 6| 6| 4| 6| 3| 8| 6| 3| 3| 3| 5| 3| 6| 8| 3| 8| 3| 8| 3| 6| 6| 3|             
                                           | 4| 0| 2| 0| 3| 7| 0| 1| 5| 8| 1| 1| 1| 9| 0| 0| 4| 1| 5| 1| 4| 0| 0| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
     100 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Dentine, Incisor, Dysplasia          |                                                                1         |             
      Dentine, Incisor, Necrosis, Focal    |                                                                          |             
      Dentine, Incisor, Necrosis,          |                                                                          |             
          Multifocal                       |                      1     1  1  1        1              1     1        1|             
      Incisor, Ameloblast, Degeneration    |                                                          2               |             
      Peridontal Tissue, Molar, Lower,     |                                                                          |             
           Inflammation, Chronic,          |                                                                          |             
          Suppurative                      |                      3                                               3   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
      Degeneration, Chronic                |       2        1  1  1        2        1  2        2     1     2  1     2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
      Degeneration, Cystic                 |                                                    2                     |             
      Hyperplasia                          |       2              2        2                    2           2        2|             
      Hypertrophy                          |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Bilateral, Degeneration, Cystic      |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
      Hyperplasia                          |                2                 2                       2               |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
      Pars Distalis, Congestion            |                      2        3  4        3        3     3               |             
      Pars Distalis, Cyst                  |       X           X                 X     X                              |             
      Pars Distalis, Hyperplasia           |          2        2           3           3                              |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
      Hyperplasia, Glandular               |       2                                                        3         |             
      Inflammation, Chronic Active         |                                                                2     2   |             
      Duct, Cyst                           |    X                                                                     |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 6| 4| 6| 6| 4| 7| 1| 5| 7| 7| 7| 4| 7| 4| 1| 7| 1| 7| 1| 7| 4| 5| 7|             
                             DAY ON TEST   | 8| 6| 6| 6| 6| 4| 6| 3| 8| 6| 3| 3| 3| 5| 3| 6| 8| 3| 8| 3| 8| 3| 6| 6| 3|             
                                           | 4| 0| 2| 0| 3| 7| 0| 1| 5| 8| 1| 1| 1| 9| 0| 0| 4| 1| 5| 1| 4| 0| 0| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
     100 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Periovarian Tissue, Cyst             |                                                                      X   |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
      Infarct, Chronic                     |                                                                          |             
      Cervix, Cyst                         |                                                                          |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |                2                                                  1     2|             
      Lumen, Hemorrhage                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
      Femoral, Atrophy                     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Fibrosis                             |                                           2                              |             
      Necrosis                             |                                                                          |             
      Red Pulp, Atrophy                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    M  +  +  +  +  +  +     +  +  M  +  +  +  +     +     +     +  +  +  +|             
      Depletion Lymphoid                   |       2     3  2     2     2  3     2     2        3     3     2     2  2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
      Hyperplasia, Cystic                  |    2  2     3  4     3     3  3  4        2  2     3     4     3  2  2  3|             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Osteosclerosis              |                                                                          |             
      Femur, Osteosclerosis                |                                                                   2      |             
      Humerus, Osteosclerosis              |                                     2                    2        2      |             
      Joint, Cartilage, Tibia, Degeneration|                                                                          |             
      Maxilla, Osteosclerosis              |                                     1                             2      |             
      Thoracic, Vertebra, Osteosclerosis   |                                     2                    2        1      |             
      Tibia, Osteosclerosis                |          1                          3                    3        2      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
      Compression                          |                            X     X                                       |             
      Hydrocephalus                        |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 6| 4| 6| 6| 4| 7| 1| 5| 7| 7| 7| 4| 7| 4| 1| 7| 1| 7| 1| 7| 4| 5| 7|             
                             DAY ON TEST   | 8| 6| 6| 6| 6| 4| 6| 3| 8| 6| 3| 3| 3| 5| 3| 6| 8| 3| 8| 3| 8| 3| 6| 6| 3|             
                                           | 4| 0| 2| 0| 3| 7| 0| 1| 5| 8| 1| 1| 1| 9| 0| 0| 4| 1| 5| 1| 4| 0| 0| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
     100 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
      Inflammation, Chronic Active         |                      2                                                   |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                  2                                       |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Squamous                 |                                                                          |             
      Mucosa, Inflammation, Acute          |                                                                      2   |             
      Mucosa, Inflammation, Chronic Active |                                     2                    2               |             
      Sinus, Foreign Body                  |                                     2                    2               |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +     +  +                                                  +|             
      Lens, Cataract                       |             3     3  3                                                  3|             
      Retina, Atrophy                      |             4     4  4                                                  4|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                                                                  |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
      Nephropathy, Chronic                 |    1  1     2  1  2  1     3  2  2  2  2  2  1     3     4     2  2     2|             
      Renal Tubule, Atrophy                |                                                                          |             
      Renal Tubule, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +  +  +     +  +  +  +  +  +  +     +     +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 4| 7| 4| 6| 7| 4| 7| 1| 7| 5| 5| 1| 7| 6| 7| 7| 6| 7| 7| 7| 1|             
                             DAY ON TEST   | 2| 3| 8| 3| 5| 3| 6| 4| 3| 6| 0| 8| 3| 7| 7| 8| 3| 4| 3| 3| 7| 3| 3| 3| 8|             
                                           | 9| 0| 5| 1| 9| 2| 0| 7| 2| 0| 8| 5| 0| 1| 5| 4| 2| 6| 0| 2| 0| 2| 2| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
     100 PPM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
      Basophilic Focus                     | X  X     X     X     X                          X  X  X           X  X   |             
      Clear Cell Focus                     | X                                               X     X              X   |             
      Congestion                           |                                                                          |             
      Eosinophilic Focus                   |                                                 X     X        X         |             
      Hepatodiaphragmatic Nodule           |                         X     X     X              X                     |             
      Hepatodiaphragmatic Nodule, Multiple | X                                                                        |             
      Hyperplasia                          |                                     3                    3  3            |             
      Inflammation, Chronic Active         |    2        2  3                                2     2        2         |             
      Mixed Cell Focus                     |                                                                          |             
      Vacuolization Cytoplasmic            |                         2     3        4  1                              |             
      Bile Duct, Hyperplasia               |                            2        3  2  1           2  2  3  2  3      |             
      Centrilobular, Necrosis              |                                                                          |             
      Hepatocyte, Degeneration, Cystic     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Congestion, Acute               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
      Acinus, Atrophy                      |    2                                                     2               |             
      Acinus, Cytomegaly, Focal            |                                                                      2   |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                +         |             
      Hyperplasia, Squamous                |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
      Acanthosis                           |                                                                          |             
      Inflammation, Chronic Active         |                                           3                              |             
      Ulcer                                |                                           2                 2            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            |                               2                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 4| 7| 4| 6| 7| 4| 7| 1| 7| 5| 5| 1| 7| 6| 7| 7| 6| 7| 7| 7| 1|             
                             DAY ON TEST   | 2| 3| 8| 3| 5| 3| 6| 4| 3| 6| 0| 8| 3| 7| 7| 8| 3| 4| 3| 3| 7| 3| 3| 3| 8|             
                                           | 9| 0| 5| 1| 9| 2| 0| 7| 2| 0| 8| 5| 0| 1| 5| 4| 2| 6| 0| 2| 0| 2| 2| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
     100 PPM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Dentine, Incisor, Dysplasia          |                                           1                              |             
      Dentine, Incisor, Necrosis, Focal    |                                                          1               |             
      Dentine, Incisor, Necrosis,          |                                                                          |             
          Multifocal                       | 1  1     1              1     1        1  1     1              1  1      |             
      Incisor, Ameloblast, Degeneration    |                                                                          |             
      Peridontal Tissue, Molar, Lower,     |                                                                          |             
           Inflammation, Chronic,          |                                                                          |             
          Suppurative                      |          3              2     3                    3                 2   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
      Degeneration, Chronic                | 1  1     2  1  1     1  2     3     3  2        1  2  2  2     2  1  1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia                          | 2  2     2              2                       2                    2   |             
      Hypertrophy                          |                      2                                   2     2         |             
      Vacuolization Cytoplasmic, Focal     |    2                          3                                          |             
      Bilateral, Degeneration, Cystic      |                                                       3                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
      Hyperplasia                          |          2                                                        2      |             
      Hypertrophy                          |                                                             2            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +  +  M  +  M  +  +     +  +  +     +  +  +  +  +  M  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
      Pars Distalis, Congestion            | 3  3           4        4           4                    3               |             
      Pars Distalis, Cyst                  |                   X  X              X           X  X     X  X            |             
      Pars Distalis, Hyperplasia           |          2        3                                   3                  |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
      C-Cell, Hyperplasia                  | 2  2     2                                                           3   |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  M     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
      Hyperplasia, Glandular               |                                     2                 2                  |             
      Inflammation, Chronic Active         |          2                                      2        2     2  1      |             
      Duct, Cyst                           |                                                             X            |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 4| 7| 4| 6| 7| 4| 7| 1| 7| 5| 5| 1| 7| 6| 7| 7| 6| 7| 7| 7| 1|             
                             DAY ON TEST   | 2| 3| 8| 3| 5| 3| 6| 4| 3| 6| 0| 8| 3| 7| 7| 8| 3| 4| 3| 3| 7| 3| 3| 3| 8|             
                                           | 9| 0| 5| 1| 9| 2| 0| 7| 2| 0| 8| 5| 0| 1| 5| 4| 2| 6| 0| 2| 0| 2| 2| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
     100 PPM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Follicle, Cyst                       |                                                       X                  |             
      Periovarian Tissue, Cyst             |                            X                                             |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
      Infarct, Chronic                     |                                                                          |             
      Cervix, Cyst                         |                                                                          |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |          2  1     1        2                       2  3                  |             
      Lumen, Hemorrhage                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
      Femoral, Atrophy                     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +  +  +  +  +  +  +     +  M  +     +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
      Depletion Lymphoid                   |                                                                          |             
      Fibrosis                             |                                                                      2   |             
      Necrosis                             |                               3                                          |             
      Red Pulp, Atrophy                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  M  +   |             
      Depletion Lymphoid                   | 4  2     2     3     3  2              3        3  2  3  3     3     3   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
      Hyperplasia, Cystic                  | 4  3     3     4  2  2  3     2     3  4  3     3  3  3  3  3  2  2  2   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +  +  +  M  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Osteosclerosis              |                                                    4                     |             
      Femur, Osteosclerosis                |                                                                          |             
      Humerus, Osteosclerosis              |                                                    4                     |             
      Joint, Cartilage, Tibia, Degeneration|                                                                          |             
      Maxilla, Osteosclerosis              |                                                                          |             
      Thoracic, Vertebra, Osteosclerosis   |                                                    4           1         |             
      Tibia, Osteosclerosis                |                                                    4     1     1         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
      Compression                          | X                       X           X     X                              |             
      Hydrocephalus                        | 3                       2                 3                              |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 7| 4| 7| 4| 6| 7| 4| 7| 1| 7| 5| 5| 1| 7| 6| 7| 7| 6| 7| 7| 7| 1|             
                             DAY ON TEST   | 2| 3| 8| 3| 5| 3| 6| 4| 3| 6| 0| 8| 3| 7| 7| 8| 3| 4| 3| 3| 7| 3| 3| 3| 8|             
                                           | 9| 0| 5| 1| 9| 2| 0| 7| 2| 0| 8| 5| 0| 1| 5| 4| 2| 6| 0| 2| 0| 2| 2| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
     100 PPM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic Active         |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                   2                                                      |             
      Alveolar Epithelium, Hyperplasia     |                                     2                                    |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic Active         |                   3                                                      |             
      Metaplasia, Squamous                 |                   2                                                      |             
      Mucosa, Inflammation, Acute          |                                                                          |             
      Mucosa, Inflammation, Chronic Active |                         2                                            2   |             
      Sinus, Foreign Body                  |                         2                                            2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +     +     +  +              +                                 |             
      Lens, Cataract                       |          3     3     3  3              3                                 |             
      Retina, Atrophy                      |          4     4     4  4              4                                 |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
      Nephropathy, Chronic                 | 3  3     4  2  3  1  1  4  2  3     2     3     3  2  2  3  1  3  3  2   |             
      Renal Tubule, Atrophy                |                                                                          |             
      Renal Tubule, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7|              |            |
                             DAY ON TEST   | 3| 3| 6| 3| 4| 4| 3| 1| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 8| 3|              |            |
                                           | 2| 2| 0| 3| 3| 7| 3| 5| 3| 0| 3| 6| 6| 0| 3| 3| 3| 0| 5| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |      A     |
     100 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  60        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  60        |
      Basophilic Focus                     | X  X     X     X  X     X     X  X     X     X  X  X     X               |     33     |
      Clear Cell Focus                     |    X                                   X  X     X                        |      9     |
      Congestion                           |                                                                          |      2  2.0|
      Eosinophilic Focus                   |                X                          X  X                           |      7     |
      Hepatodiaphragmatic Nodule           |                         X                                                |     10     |
      Hepatodiaphragmatic Nodule, Multiple |                                                                          |      1     |
      Hyperplasia                          |                                                                          |      3  3.0|
      Inflammation, Chronic Active         |                                     1           3        1               |     16  1.9|
      Mixed Cell Focus                     |                                                 X                        |      1     |
      Vacuolization Cytoplasmic            |                                                                          |      7  2.6|
      Bile Duct, Hyperplasia               |       1  1  3           1        2     2                                 |     18  2.0|
      Centrilobular, Necrosis              |                                                                          |      1  3.0|
      Hepatocyte, Degeneration, Cystic     |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Fat, Congestion, Acute               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  60        |
      Acinus, Atrophy                      |                1        3        2                                       |      7  2.0|
      Acinus, Cytomegaly, Focal            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   2        |
      Hyperplasia, Squamous                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  59        |
      Acinus, Atrophy                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  60        |
      Acanthosis                           |                                                    3                     |      2  2.5|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  60        |
      Necrosis                             |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7|              |            |
                             DAY ON TEST   | 3| 3| 6| 3| 4| 4| 3| 1| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 8| 3|              |            |
                                           | 2| 2| 0| 3| 3| 7| 3| 5| 3| 0| 3| 6| 6| 0| 3| 3| 3| 0| 5| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |      A     |
     100 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Ulcer                                |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                      +                                                   |   1        |
      Hyperplasia, Squamous                |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Dentine, Incisor, Dysplasia          |             1                 2                                          |      4  1.3|
      Dentine, Incisor, Necrosis, Focal    |                1                       1  1                              |      4  1.0|
      Dentine, Incisor, Necrosis,          |                                                                          |            |
          Multifocal                       | 1        1  1     1        1  4     1        1                           |     26  1.1|
      Incisor, Ameloblast, Degeneration    |                                                                          |      1  2.0|
      Peridontal Tissue, Molar, Lower,     |                                                                          |            |
           Inflammation, Chronic,          |                                                                          |            |
          Suppurative                      | 2           3  3                                                         |     10  2.7|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  60        |
      Degeneration, Chronic                | 2  1  1  1        1     3  1  1     2  2     2  1  2     1               |     43  1.6|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  60        |
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Hyperplasia                          | 2  2           2           3           2     2                           |     18  2.1|
      Hypertrophy                          | 3        2                                                               |      5  2.2|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      2  2.5|
      Bilateral, Degeneration, Cystic      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  60        |
      Hyperplasia                          | 2                       2  2                                             |      8  2.0|
      Hypertrophy                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  60        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  55        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  60        |
      Pars Distalis, Congestion            |    2              3                    3  2        3                     |     17  3.1|
      Pars Distalis, Cyst                  | X  X                 X  X        X                       X               |     17     |
      Pars Distalis, Hyperplasia           |    3                 3  2                                                |     10  2.6|
      Pars Intermedia, Hyperplasia         |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  60        |
      C-Cell, Hyperplasia                  | 2        2              2  2                    2                        |      9  2.1|
      Follicular Cell, Hyperplasia         | 3                                                                        |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7|              |            |
                             DAY ON TEST   | 3| 3| 6| 3| 4| 4| 3| 1| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 8| 3|              |            |
                                           | 2| 2| 0| 3| 3| 7| 3| 5| 3| 0| 3| 6| 6| 0| 3| 3| 3| 0| 5| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |      A     |
     100 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  59        |
      Hyperplasia, Glandular               | 3                       2                                                |      6  2.3|
      Inflammation, Chronic Active         |                   2  2     1        3                                    |     11  1.9|
      Duct, Cyst                           |                                                 X                        |      3     |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  60        |
      Follicle, Cyst                       |                                                                          |      1     |
      Periovarian Tissue, Cyst             |                               X                                          |      3     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  60        |
      Infarct, Chronic                     |                                                    3                     |      1  3.0|
      Cervix, Cyst                         | X        X                                                               |      2     |
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       |          2     2                                                         |     11  1.8|
      Lumen, Hemorrhage                    |                                              4  4                        |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  60        |
      Femoral, Atrophy                     |                      4                                                   |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  60        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  59        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  59        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  60        |
      Depletion Lymphoid                   |                      2                                                   |      1  2.0|
      Fibrosis                             |                                                                          |      2  2.0|
      Necrosis                             |                                                                          |      1  3.0|
      Red Pulp, Atrophy                    |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  56        |
      Depletion Lymphoid                   | 3  2  2  2     3  2  4  2     2  3  3  3  4  4  4  2     2               |     43  2.6|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  60        |
      Hyperplasia, Cystic                  | 2     2     3  3  4  2  2  3  2  2  2  2  3  2  3  3     2               |     52  2.7|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  59        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Cranium, Osteosclerosis              |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7|              |            |
                             DAY ON TEST   | 3| 3| 6| 3| 4| 4| 3| 1| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 8| 3|              |            |
                                           | 2| 2| 0| 3| 3| 7| 3| 5| 3| 0| 3| 6| 6| 0| 3| 3| 3| 0| 5| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |      A     |
     100 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Femur, Osteosclerosis                |                                                                          |      1  2.0|
      Humerus, Osteosclerosis              |                                                                          |      4  2.5|
      Joint, Cartilage, Tibia, Degeneration|             1                                                            |      1  1.0|
      Maxilla, Osteosclerosis              |                                                                          |      2  1.5|
      Thoracic, Vertebra, Osteosclerosis   |                                                                          |      5  2.0|
      Tibia, Osteosclerosis                |                      3              2                                    |      9  2.2|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  60        |
      Compression                          |                X                                                         |      7     |
      Hydrocephalus                        |                3                                                         |      5  2.8|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  60        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  60        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Metaplasia, Squamous                 |                                                                          |      1  2.0|
      Mucosa, Inflammation, Acute          |                                                                          |      1  2.0|
      Mucosa, Inflammation, Chronic Active |                                                          2               |      5  2.0|
      Sinus, Foreign Body                  |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +     +                                +                              |  13        |
      Lens, Cataract                       | 3  3     3                                3                              |     13  3.0|
      Retina, Atrophy                      | 4  4     4                                4                              |     13  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  60        |
      Nephropathy, Chronic                 | 3  3  3  1     1  3     1  2  2  1  3  3  2  4  1  3     2               |     55  2.2|
      Renal Tubule, Atrophy                |                   4                                                      |      1  4.0|
      Renal Tubule, Inflammation, Chronic  |                                                                          |            |
          Active                           |                   4                                                      |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7|              |            |
                             DAY ON TEST   | 3| 3| 6| 3| 4| 4| 3| 1| 3| 3| 3| 1| 1| 3| 3| 3| 3| 3| 8| 3|              |            |
                                           | 2| 2| 0| 3| 3| 7| 3| 5| 3| 0| 3| 6| 6| 0| 3| 3| 3| 0| 5| 3|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |      A     |
     100 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +               |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 4| 4| 7| 7| 7| 6| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 5| 6| 5| 7| 7| 7| 4|             
                             DAY ON TEST   | 8| 6| 1| 5| 3| 3| 3| 4| 3| 3| 3| 3| 5| 3| 0| 3| 3| 3| 7| 4| 6| 0| 3| 3| 6|             
                                           | 5| 0| 5| 9| 1| 1| 1| 7| 1| 1| 1| 1| 9| 1| 9| 1| 1| 1| 1| 6| 1| 5| 1| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
     175 PPM                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X     X  X     X        X  X  X     X     X  X  X     X     X  X  X  X|             
      Clear Cell Focus                     |                                                    X                     |             
      Eosinophilic Focus                   |             X                                                            |             
      Hepatodiaphragmatic Nodule           | X                                                           X           X|             
      Hepatodiaphragmatic Nodule, Multiple |                                                                          |             
      Inflammation, Chronic Active         |                2              1     1  2              2        3     2  1|             
      Mixed Cell Focus                     |                                                                          |             
      Vacuolization Cytoplasmic            |       2                 3                 4           1                  |             
      Bile Duct, Hyperplasia               |          2              3                 4                    2  3      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Inflammation, Chronic Active    |                                                                          |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |          2        1           2              1  2     1        2         |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |             3                                                            |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                           2                              |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                2         |             
      Pigmentation, Hemosiderin            |                         2                                                |             
      Ulcer                                |                                           2                              |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dentine, Incisor, Dysplasia          |                   1                                1                     |             
      Dentine, Incisor, Necrosis, Focal    |                                                                      1   |             
      Dentine, Incisor, Necrosis,          |                                                                          |             
          Multifocal                       |                         1  1  1  1        1  1  1     1  1  1  1         |             
      Incisor, Odontoblast, Degeneration   |                                                                          |             
      Incisor, Ameloblast, Degeneration    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 4| 4| 7| 7| 7| 6| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 5| 6| 5| 7| 7| 7| 4|             
                             DAY ON TEST   | 8| 6| 1| 5| 3| 3| 3| 4| 3| 3| 3| 3| 5| 3| 0| 3| 3| 3| 7| 4| 6| 0| 3| 3| 6|             
                                           | 5| 0| 5| 9| 1| 1| 1| 7| 1| 1| 1| 1| 9| 1| 9| 1| 1| 1| 1| 6| 1| 5| 1| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
     175 PPM                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Peridontal Tissue, Molar,            |                                                                          |             
          Inflammation, Suppurative        |          2                                                               |             
      Peridontal Tissue, Molar, Lower,     |                                                                          |             
           Inflammation, Chronic,          |                                                                          |             
          Suppurative                      |             3           2                    3  2  3                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Chronic                |    2  1     1  2  2  2     2     1  1  2  1  2  1  2     2     2  2  2   |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Degeneration, Cystic                 |                3                                                  2      |             
      Hyperplasia                          |                                        2        2                    2   |             
      Hypertrophy                          |                         2                                               1|             
      Vacuolization Cytoplasmic, Focal     |       2                 2                                                |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |             2                             2  2     2                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Congestion            |                2           3           3           3              2  3   |             
      Pars Distalis, Cyst                  |    X        X  X  X  X           X                       X               |             
      Pars Distalis, Hemorrhage            |                3                                            4            |             
      Pars Distalis, Hyperplasia           |    1  2                    2                 2  3        2           3   |             
      Pars Intermedia, Cyst                |                X                             X                           |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                                                      2   |             
      Follicle, Cyst                       |                                  X                 X                     |             
      Follicular Cell, Hyperplasia         |                                  2                 2           3         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +|             
      Hyperplasia, Glandular               |                               2              2                           |             
      Hyperplasia                          |          2                                                               |             
      Inflammation, Chronic Active         |             1              3  2     1                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 4| 4| 7| 7| 7| 6| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 5| 6| 5| 7| 7| 7| 4|             
                             DAY ON TEST   | 8| 6| 1| 5| 3| 3| 3| 4| 3| 3| 3| 3| 5| 3| 0| 3| 3| 3| 7| 4| 6| 0| 3| 3| 6|             
                                           | 5| 0| 5| 9| 1| 1| 1| 7| 1| 1| 1| 1| 9| 1| 9| 1| 1| 1| 1| 6| 1| 5| 1| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
     175 PPM                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Duct, Cyst                           |                                                                X         |             
      Duct, Hyperplasia, Squamous          |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Periovarian Tissue, Cyst  |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Cervix, Cyst                         |                                        X                       X         |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |                   2     2        2                                      2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Myelofibrosis               |                         3                                                |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Granulomatous          |                                                                4         |             
      Thrombosis                           |                                                                          |             
      Capsule, Fibrosis                    |                                           2                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Depletion Lymphoid                   |             2  3  2  2  4  3  2  2     3  3  3  3  4     3        3  2   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |          2  3     3  3  3  1  3  3  1  3  3  2  4  3  3     3  4  3  3   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Fibrous Osteodystrophy        |                                                                          |             
      Humerus, Osteosclerosis              |                   2                                4                     |             
      Maxilla, Osteosclerosis              |                                                    2                     |             
      Thoracic, Vertebra, Osteosclerosis   |                   2                                3                     |             
      Tibia, Osteosclerosis                |                   2                                4                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                       X     X  X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 4| 4| 7| 7| 7| 6| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 5| 6| 5| 7| 7| 7| 4|             
                             DAY ON TEST   | 8| 6| 1| 5| 3| 3| 3| 4| 3| 3| 3| 3| 5| 3| 0| 3| 3| 3| 7| 4| 6| 0| 3| 3| 6|             
                                           | 5| 0| 5| 9| 1| 1| 1| 7| 1| 1| 1| 1| 9| 1| 9| 1| 1| 1| 1| 6| 1| 5| 1| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
     175 PPM                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                                2         |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                         2                                                |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                         2|             
      Mucosa, Inflammation, Acute          |                                                                          |             
      Mucosa, Inflammation, Chronic Active |       2        2        3                       2              3  3      |             
      Mucosa, Ulcer                        |                                                                          |             
      Sinus, Foreign Body                  |                2        2                       2              3  2      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                           +                              |             
      Pinna, Inflammation, Chronic Active  |                                           3                              |             
                                            __________________________________________________________________________|             
   Eye                                     |                +  +     +  +                                             |             
      Anterior Chamber, Hemorrhage         |                                                                          |             
      Cornea, Inflammation, Acute          |                                                                          |             
      Lens, Cataract                       |                3  3     3  3                                             |             
      Retina, Atrophy                      |                4  4     4  4                                             |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Nephropathy, Chronic                 |       2  1  2  1  1     1  2  2  1  1  2  3  2  2  3  3  1     2  2  1  1|             
      Cortex, Infarct, Chronic, Multifocal |                   3                                                      |             
      Renal Tubule, Mineralization         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 5| 7| 7| 7| 5| 7| 7| 6| 5| 7| 7| 3| 6| 7| 7| 7| 6| 1| 7| 1| 7| 4|             
                             DAY ON TEST   | 3| 3| 8| 5| 3| 2| 3| 1| 3| 3| 2| 7| 3| 3| 3| 3| 3| 3| 3| 1| 8| 3| 8| 3| 6|             
                                           | 0| 1| 4| 7| 1| 2| 1| 5| 1| 2| 8| 8| 2| 0| 8| 1| 2| 0| 2| 3| 5| 2| 5| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
     175 PPM                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X        X           X           X           X     X        X     X   |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |                X                 X                 X  X                  |             
      Hepatodiaphragmatic Nodule, Multiple |                         X                                                |             
      Inflammation, Chronic Active         | 2  2              2                                      2           2   |             
      Mixed Cell Focus                     |                   X                             X                        |             
      Vacuolization Cytoplasmic            |          4  2     1  2     3  2     2                    2               |             
      Bile Duct, Hyperplasia               |    2     2              1  3        2        2     2  2                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                                    |             
      Fat, Inflammation, Chronic Active    |                                     3                                    |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                               +                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |          1     2                                      2                  |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Inflammation, Chronic Active         |                      2                                   3               |             
      Ulcer                                |          3           3              3                    3               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |          2                 2                                             |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dentine, Incisor, Dysplasia          |                                     1        2                           |             
      Dentine, Incisor, Necrosis, Focal    |                         1                       1                        |             
      Dentine, Incisor, Necrosis,          |                                                                          |             
          Multifocal                       |             1  1     1        1  1  1              1  1  1     1     1   |             
      Incisor, Odontoblast, Degeneration   |                                                                          |             
      Incisor, Ameloblast, Degeneration    |                            1  1                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 5| 7| 7| 7| 5| 7| 7| 6| 5| 7| 7| 3| 6| 7| 7| 7| 6| 1| 7| 1| 7| 4|             
                             DAY ON TEST   | 3| 3| 8| 5| 3| 2| 3| 1| 3| 3| 2| 7| 3| 3| 3| 3| 3| 3| 3| 1| 8| 3| 8| 3| 6|             
                                           | 0| 1| 4| 7| 1| 2| 1| 5| 1| 2| 8| 8| 2| 0| 8| 1| 2| 0| 2| 3| 5| 2| 5| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
     175 PPM                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Peridontal Tissue, Molar,            |                                                                          |             
          Inflammation, Suppurative        |                                                                4         |             
      Peridontal Tissue, Molar, Lower,     |                                                                          |             
           Inflammation, Chronic,          |                                                                          |             
          Suppurative                      |                3  3                 2                                    |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Chronic                | 2  2  1  1  1  2  2  2  1     1  2  1  1  2  2  2  2  2        2     2   |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia                          | 2  2                                   2        2  2                     |             
      Hypertrophy                          |                            2                                   2         |             
      Vacuolization Cytoplasmic, Focal     |                            2                    2                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                                2         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Congestion            | 3                                   4           3                    3   |             
      Pars Distalis, Cyst                  |    X        X     X     X  X                    X  X  X  X     X         |             
      Pars Distalis, Hemorrhage            |                3                                                         |             
      Pars Distalis, Hyperplasia           |                                                    2  2                 2|             
      Pars Intermedia, Cyst                |                            X                                             |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                         2     2                                2         |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                         1                                                |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Glandular               |                2                                                         |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |                         1                                      4         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 5| 7| 7| 7| 5| 7| 7| 6| 5| 7| 7| 3| 6| 7| 7| 7| 6| 1| 7| 1| 7| 4|             
                             DAY ON TEST   | 3| 3| 8| 5| 3| 2| 3| 1| 3| 3| 2| 7| 3| 3| 3| 3| 3| 3| 3| 1| 8| 3| 8| 3| 6|             
                                           | 0| 1| 4| 7| 1| 2| 1| 5| 1| 2| 8| 8| 2| 0| 8| 1| 2| 0| 2| 3| 5| 2| 5| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
     175 PPM                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Duct, Cyst                           |             X                 X                                          |             
      Duct, Hyperplasia, Squamous          |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Periovarian Tissue, Cyst  |                                                    X                     |             
      Follicle, Cyst                       |                                                                          |             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Cervix, Cyst                         |                                                                          |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Myelofibrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                2                                                         |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Thrombosis                           |          X                                                               |             
      Capsule, Fibrosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Depletion Lymphoid                   | 3  3        4  2  3  2  3  3  2  2  3  3  3  2  3  3  2  3           1   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2  3     3  4  3  2  2  3  3  2  2  4  2     3  3  2  3        2     3   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Fibrous Osteodystrophy        |                                                                          |             
      Humerus, Osteosclerosis              |             3                    2                 1                     |             
      Maxilla, Osteosclerosis              |                                                                          |             
      Thoracic, Vertebra, Osteosclerosis   |             3                    2                 1                     |             
      Tibia, Osteosclerosis                | 1           4                                                            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                X                    X                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 1| 5| 7| 7| 7| 5| 7| 7| 6| 5| 7| 7| 3| 6| 7| 7| 7| 6| 1| 7| 1| 7| 4|             
                             DAY ON TEST   | 3| 3| 8| 5| 3| 2| 3| 1| 3| 3| 2| 7| 3| 3| 3| 3| 3| 3| 3| 1| 8| 3| 8| 3| 6|             
                                           | 0| 1| 4| 7| 1| 2| 1| 5| 1| 2| 8| 8| 2| 0| 8| 1| 2| 0| 2| 3| 5| 2| 5| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
     175 PPM                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |                                              2                           |             
      Hydrocephalus                        |                                     3                                    |             
      Necrosis                             |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                                                                      2   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mucosa, Inflammation, Acute          |                      2                                                   |             
      Mucosa, Inflammation, Chronic Active |    3              3                       2                          3   |             
      Mucosa, Ulcer                        |                      2                                                   |             
      Sinus, Foreign Body                  |    2              2                                                  2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Pinna, Inflammation, Chronic Active  |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +              +     +  +  +                          +               |             
      Anterior Chamber, Hemorrhage         |                                                          3               |             
      Cornea, Inflammation, Acute          |                                                          3               |             
      Lens, Cataract                       |    3              3     3  3  3                                          |             
      Retina, Atrophy                      |    4              4     4  4  4                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +                                                            |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                           3                              |             
      Nephropathy, Chronic                 | 2  2     1  2  2  2  1  1  1  2     4  2  2     3  2     1     2     3   |             
      Cortex, Infarct, Chronic, Multifocal |                                                                          |             
      Renal Tubule, Mineralization         |                                                                   1      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 1| 6| 4| 4| 7| 1| 7| 7| 1| 7| 6| 7| 7| 7| 4| 7| 1| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 1| 3| 4| 8| 4| 5| 5| 1| 8| 1| 1| 8| 3| 3| 3| 3| 3| 5| 3| 8| 3| 3|             
                                           | 2| 6| 2| 6| 2| 7| 5| 7| 9| 9| 9| 5| 9| 9| 4| 0| 9| 2| 0| 2| 9| 0| 4| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
     175 PPM                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X     X                 X     X  X     X  X  X  X        X         |             
      Clear Cell Focus                     |       X                                                                  |             
      Eosinophilic Focus                   |       X                                      X     X     X               |             
      Hepatodiaphragmatic Nodule           |    X     X                                   X                 X         |             
      Hepatodiaphragmatic Nodule, Multiple |                                                                          |             
      Inflammation, Chronic Active         |                         2  2                                1        2   |             
      Mixed Cell Focus                     |                                                                          |             
      Vacuolization Cytoplasmic            |          2     4                                         1              4|             
      Bile Duct, Hyperplasia               |                      2                             2     1           2  3|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Inflammation, Chronic Active    |                                                                          |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                               +                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |          2                                         1           1        2|             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                 +                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                               2                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                 2                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Ulcer                                |                2     3                                                   |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dentine, Incisor, Dysplasia          |                1     2                          1                        |             
      Dentine, Incisor, Necrosis, Focal    |                                                    1                     |             
      Dentine, Incisor, Necrosis,          |                                                                          |             
          Multifocal                       |       1  1  1  1     1        2     1        1        1        1     1   |             
      Incisor, Odontoblast, Degeneration   |                      1                                                   |             
      Incisor, Ameloblast, Degeneration    |          1  2        4                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 1| 6| 4| 4| 7| 1| 7| 7| 1| 7| 6| 7| 7| 7| 4| 7| 1| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 1| 3| 4| 8| 4| 5| 5| 1| 8| 1| 1| 8| 3| 3| 3| 3| 3| 5| 3| 8| 3| 3|             
                                           | 2| 6| 2| 6| 2| 7| 5| 7| 9| 9| 9| 5| 9| 9| 4| 0| 9| 2| 0| 2| 9| 0| 4| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
     175 PPM                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Peridontal Tissue, Molar,            |                                                                          |             
          Inflammation, Suppurative        |                         4  2                                             |             
      Peridontal Tissue, Molar, Lower,     |                                                                          |             
           Inflammation, Chronic,          |                                                                          |             
          Suppurative                      | 2     3  3                             2                 3               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Chronic                | 2  1        1  1        1  1        2  1     1  2  2  2  3     2     1  2|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia                          |          2                                      2        2               |             
      Hypertrophy                          | 2                                                     2              2   |             
      Vacuolization Cytoplasmic, Focal     |    2                 3                                               2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                          2               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Congestion            | 3        3                                   4           3              3|             
      Pars Distalis, Cyst                  |             X                                         X        X     X   |             
      Pars Distalis, Hemorrhage            |                                        4                                 |             
      Pars Distalis, Hyperplasia           |       3     2                                                  2         |             
      Pars Intermedia, Cyst                |             X                                                            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                                    2        2  2         |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Glandular               |    3                                                                     |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |          2           2              2        1           2              1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 1| 6| 4| 4| 7| 1| 7| 7| 1| 7| 6| 7| 7| 7| 4| 7| 1| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 1| 3| 4| 8| 4| 5| 5| 1| 8| 1| 1| 8| 3| 3| 3| 3| 3| 5| 3| 8| 3| 3|             
                                           | 2| 6| 2| 6| 2| 7| 5| 7| 9| 9| 9| 5| 9| 9| 4| 0| 9| 2| 0| 2| 9| 0| 4| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
     175 PPM                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Duct, Cyst                           |                                                                          |             
      Duct, Hyperplasia, Squamous          |                                        3                                 |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Periovarian Tissue, Cyst  |                                                                          |             
      Follicle, Cyst                       |                                        X                                 |             
      Periovarian Tissue, Cyst             |                                  X                             X         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Cervix, Cyst                         |                                                                          |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |                            1                       3  3                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Myelofibrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                4         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                 3                        |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Thrombosis                           |                                                                          |             
      Capsule, Fibrosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Depletion Lymphoid                   | 2  2     3  3  3     3        3     3  2     3  3  4  4  4     3     4   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2  3  3  4  3  4     3        2     3  3  2  2  2  2  3  3              3|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Fibrous Osteodystrophy        | 2                                                                        |             
      Humerus, Osteosclerosis              |                                                    1                     |             
      Maxilla, Osteosclerosis              |                                                                          |             
      Thoracic, Vertebra, Osteosclerosis   |                                                    2                     |             
      Tibia, Osteosclerosis                |       3                                            3                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |          X     X     X                                   X               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 1| 6| 4| 4| 7| 1| 7| 7| 1| 7| 6| 7| 7| 7| 4| 7| 1| 7| 7|             
                             DAY ON TEST   | 3| 1| 3| 1| 3| 4| 8| 4| 5| 5| 1| 8| 1| 1| 8| 3| 3| 3| 3| 3| 5| 3| 8| 3| 3|             
                                           | 2| 6| 2| 6| 2| 7| 5| 7| 9| 9| 9| 5| 9| 9| 4| 0| 9| 2| 0| 2| 9| 0| 4| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
     175 PPM                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |          2     3     3                                   3               |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |       2                                                        2         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mucosa, Inflammation, Acute          |                                                                          |             
      Mucosa, Inflammation, Chronic Active |          2           3                 3                             2   |             
      Mucosa, Ulcer                        |                      2                                                   |             
      Sinus, Foreign Body                  |          2           3                 3                             3   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                      +                                                   |             
      Pinna, Inflammation, Chronic Active  |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +        +  +  +     +              +           +                    +   |             
      Anterior Chamber, Hemorrhage         |                                                                          |             
      Cornea, Inflammation, Acute          |                                                                          |             
      Lens, Cataract                       | 3        3  3  3     3              3           4                    3   |             
      Retina, Atrophy                      | 4        4  4  4     4              4           4                    4   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Nephropathy, Chronic                 | 2  1  2  3  3  3     2  1     3     2  2     2  2  3  2  2  1  2     2  3|             
      Cortex, Infarct, Chronic, Multifocal |                                                                          |             
      Renal Tubule, Mineralization         |                   1                                                      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 7| 1| 8| 3| 1| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3|            |
                                           | 2| 2| 8| 4| 5| 2| 6| 0| 3| 3| 3| 3| 3| 4| 3| 0| 3| 3| 3| 9| 3| 3| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
     175 PPM                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  98        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Basophilic Focus                     | X  X           X  X        X  X  X  X     X  X  X  X        X  X  X      |     52     |
      Clear Cell Focus                     |                         X     X     X              X           X        X|      8     |
      Eosinophilic Focus                   |                               X  X  X                             X      |      9     |
      Hepatodiaphragmatic Nodule           |       X              X                                      X  X         |     15     |
      Hepatodiaphragmatic Nodule, Multiple |                                                                          |      1     |
      Inflammation, Chronic Active         | 2                          1  2              1                 2     2  2|     24  1.8|
      Mixed Cell Focus                     |                                                                          |      2     |
      Vacuolization Cytoplasmic            |       3           2                                   3                  |     19  2.5|
      Bile Duct, Hyperplasia               |       2              4                                2        2        3|     23  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                       +                  |   2        |
      Fat, Inflammation, Chronic Active    |                                                       3                  |      2  3.0|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
      Acinus, Atrophy                      |       3           2     1        1              1        1     2         |     21  1.6|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  97        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Acanthosis                           |                                                       3                  |      3  2.7|
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
      Ulcer                                |                                                                          |      6  2.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Necrosis                             |                                                                          |      3  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                  +                                       |   1        |
      Hyperplasia, Squamous                |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Dentine, Incisor, Dysplasia          |    1  3                                                        2         |     10  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 7| 1| 8| 3| 1| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3|            |
                                           | 2| 2| 8| 4| 5| 2| 6| 0| 3| 3| 3| 3| 3| 4| 3| 0| 3| 3| 3| 9| 3| 3| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
     175 PPM                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Dentine, Incisor, Necrosis, Focal    |                                                                          |      4  1.0|
      Dentine, Incisor, Necrosis,          |                                                                          |            |
          Multifocal                       | 1  1  1  1     1  1  1  1  1  1  1  1        1  1  1  1        1  1  1  1|     53  1.0|
      Incisor, Odontoblast, Degeneration   |       1                                                                  |      2  1.0|
      Incisor, Ameloblast, Degeneration    |       4                                                        3         |      7  2.3|
      Peridontal Tissue, Molar,            |                                                                          |            |
          Inflammation, Suppurative        |                                                                          |      4  3.0|
      Peridontal Tissue, Molar, Lower,     |                                                                          |            |
           Inflammation, Chronic,          |                                                                          |            |
          Suppurative                      | 2  3  3                 3  2        2                             2  2   |     21  2.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Degeneration, Chronic                | 2  1  3  2  1  1        1  1  2  1        1     1  1        1        1   |     69  1.6|
      Inflammation, Chronic Active         |                                                                         4|      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Accessory Adrenal Cortical Nodule    |                                                                X         |      1     |
      Degeneration, Cystic                 |                                                                   2      |      3  2.3|
      Hyperplasia                          |    2                             2                          2     2      |     15  2.0|
      Hypertrophy                          |                                                    2              2  2   |     10  1.9|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      7  2.1|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Cyst                                 |                                                                      X   |      1     |
      Hyperplasia                          |                                                                          |      6  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
      Hyperplasia                          |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  97        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Pars Distalis, Congestion            |    3           4           2     3           3        3              3   |     22  3.0|
      Pars Distalis, Cyst                  | X  X     X                 X                    X  X           X  X     X|     30     |
      Pars Distalis, Hemorrhage            |                   3                                                      |      5  3.4|
      Pars Distalis, Hyperplasia           |    2                                2     2                 2  2        3|     19  2.2|
      Pars Intermedia, Cyst                |                                                                          |      4     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      C-Cell, Hyperplasia                  |                                                                2         |      8  2.0|
      Follicle, Cyst                       |                                                                          |      2     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 7| 1| 8| 3| 1| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3|            |
                                           | 2| 2| 8| 4| 5| 2| 6| 0| 3| 3| 3| 3| 3| 4| 3| 0| 3| 3| 3| 9| 3| 3| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
     175 PPM                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Follicular Cell, Hyperplasia         |                                                                          |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  98        |
      Hyperplasia, Glandular               | 3                       2                                                |      6  2.3|
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                1           2              3  2     3              2      |     18  1.9|
      Duct, Cyst                           |                   X                                X                     |      5     |
      Duct, Hyperplasia, Squamous          |                                                                      3   |      2  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Bilateral, Periovarian Tissue, Cyst  |                                                                          |      1     |
      Follicle, Cyst                       |                                                                          |      1     |
      Periovarian Tissue, Cyst             |                      X     X                                             |      4     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Hemorrhage                           |       2                                                                  |      1  2.0|
      Cervix, Cyst                         |                   X                                               X      |      4     |
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       |    3  4              3                                   1        2     2|     13  2.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Femoral, Myelofibrosis               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Angiectasis                          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Depletion Lymphoid                   |                                                                          |      2  2.5|
      Hematopoietic Cell Proliferation     |          3                                                               |      1  3.0|
      Inflammation, Granulomatous          |                                                                          |      1  4.0|
      Thrombosis                           |                                                                          |      1     |
      Capsule, Fibrosis                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  95        |
      Depletion Lymphoid                   | 3  3  3  3     3  3  4  2  2  2  2  2     3  3  2  2  3     3  4  3  3  2|     73  2.8|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 7| 1| 8| 3| 1| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3|            |
                                           | 2| 2| 8| 4| 5| 2| 6| 0| 3| 3| 3| 3| 3| 4| 3| 0| 3| 3| 3| 9| 3| 3| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
     175 PPM                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
      Hyperplasia, Cystic                  | 2  3  4  3     4  3  2  2  3  4  3  3     2  3  2  2  3     2  2  3  2  2|     77  2.7|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Femur, Fibrous Osteodystrophy        |                                                                          |      1  2.0|
      Humerus, Osteosclerosis              |                   2  1  2                       2                    2   |     11  2.0|
      Maxilla, Osteosclerosis              |                                                    1                 2   |      3  1.7|
      Thoracic, Vertebra, Osteosclerosis   |    1              2  2  1                    2  2  1              1  2   |     15  1.8|
      Tibia, Osteosclerosis                |                   1  2  3                    2  2  3              1  3  1|     15  2.3|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Compression                          |                X                                                         |     10     |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hydrocephalus                        |                                                                          |      6  2.7|
      Necrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Alveolar Epithelium, Hyperplasia     |    2                                                                     |      5  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Mucosa, Inflammation, Acute          |                                                                          |      1  2.0|
      Mucosa, Inflammation, Chronic Active |    3     4     2                                                  3      |     18  2.7|
      Mucosa, Ulcer                        |                                                                          |      2  2.0|
      Sinus, Foreign Body                  |    2     3                                                        3      |     15  2.4|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  98        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
      Pinna, Inflammation, Chronic Active  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |    +     +     +  +  +  +  +                                         +   |  26        |
      Anterior Chamber, Hemorrhage         |                                                                          |      1  3.0|
      Cornea, Inflammation, Acute          |                                                                          |      1  3.0|
      Lens, Cataract                       |    3     3     3  3  3  3  3                                         3   |     25  3.0|
      Retina, Atrophy                      |    4     4     4  4  4  4  4                                         4   |     25  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  67                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 7| 1| 8| 3| 1| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3|            |
                                           | 2| 2| 8| 4| 5| 2| 6| 0| 3| 3| 3| 3| 3| 4| 3| 0| 3| 3| 3| 9| 3| 3| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
     175 PPM                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
      Hydronephrosis                       |                                                                          |      1  3.0|
      Nephropathy, Chronic                 | 1  3  3  2     2  2  2  1  2  3  2  2     1  3  2  3  1  1  2  3  1  2  1|     82  1.9|
      Cortex, Infarct, Chronic, Multifocal |                                                                          |      1  3.0|
      Renal Tubule, Mineralization         |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +| 100        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  68                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 4| 7| 7| 5| 0| 0| 7| 1| 7| 7| 7| 7| 4| 7| 1| 4| 1| 6| 6| 1|             
                             DAY ON TEST   | 1| 2| 1| 3| 3| 6| 2| 3| 4| 5| 5| 3| 8| 1| 3| 3| 2| 6| 3| 8| 5| 8| 5| 6| 8|             
                                           | 8| 9| 7| 0| 0| 0| 9| 0| 3| 9| 9| 0| 4| 2| 0| 0| 9| 0| 0| 4| 9| 5| 6| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
     0 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  M     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                      X                          X  X        X            |             
      Clear Cell Focus                     |    X              X  X                       X  X     X     X            |             
      Eosinophilic Focus                   |             X                                                            |             
      Hepatodiaphragmatic Nodule           |                                              X        X              X   |             
      Hyperplasia                          |          3                                                               |             
      Inflammation, Chronic Active         |       1        1                                   1                     |             
      Vacuolization Cytoplasmic            |                3  2     3                                   2            |             
      Bile Duct, Hyperplasia               | 3        4  2  2  2  2           2     2  3  3  2  2  2     2     4  3   |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                                                                          |             
      Hepatocyte, Degeneration, Cystic     | 4                                2           2                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                    +                                         +      |             
      Fat, Inflammation, Chronic Active    |    3                    3                                         3      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  A     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 3        3     2        2              3                 2  2            |             
      Acinus, Hyperplasia                  |             2                                                            |             
      Artery, Inflammation, Chronic Active |                                                 3                        |             
      Vein, Thrombosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  A     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  A     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           | 3                       2                                                |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                         2                                                |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                                                      3   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  A     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dysplasia                            |    2                                                                     |             
      Hyperplasia                          |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                                          |             
      Ulcer                                | 3                                                                 2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 4| 7| 7| 5| 0| 0| 7| 1| 7| 7| 7| 7| 4| 7| 1| 4| 1| 6| 6| 1|             
                             DAY ON TEST   | 1| 2| 1| 3| 3| 6| 2| 3| 4| 5| 5| 3| 8| 1| 3| 3| 2| 6| 3| 8| 5| 8| 5| 6| 8|             
                                           | 8| 9| 7| 0| 0| 0| 9| 0| 3| 9| 9| 0| 4| 2| 0| 0| 9| 0| 0| 4| 9| 5| 6| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
     0 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dentine, Incisor, Dysplasia          | 1        1                                                               |             
      Dentine, Incisor, Necrosis,          |                                                                          |             
          Multifocal                       | 2  1     1  1     2  1  1        1     1  1  1  1     1           1  1   |             
      Peridontal Tissue, Molar,            |                                                                          |             
          Inflammation, Chronic,           |                                                                          |             
          Suppurative                      |                                                                          |             
      Peridontal Tissue, Molar,            |                                                                          |             
          Inflammation, Suppurative        |                                                    4        4            |             
      Peridontal Tissue, Molar, Lower,     |                                                                          |             
           Inflammation, Chronic,          |                                                                          |             
          Suppurative                      |                                           3           2                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Chronic                | 2  3  2     2  2  3  3  2        2  2  3  2  2  2  3  2  2  2  1  2  2  1|             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |    3                             2                    3           2      |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |          2              2                    2                    3  2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  A     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Congestion            |                                                                          |             
      Pars Distalis, Cyst                  |                      X           X                                       |             
      Pars Distalis, Hemorrhage            |    3              3                                   3                  |             
      Pars Distalis, Hyperplasia           |    3              3              3           2  2     3                  |             
      Pars Distalis, Inflammation, Chronic |                                                                          |             
          Active                           |                                                                          |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 4| 7| 7| 5| 0| 0| 7| 1| 7| 7| 7| 7| 4| 7| 1| 4| 1| 6| 6| 1|             
                             DAY ON TEST   | 1| 2| 1| 3| 3| 6| 2| 3| 4| 5| 5| 3| 8| 1| 3| 3| 2| 6| 3| 8| 5| 8| 5| 6| 8|             
                                           | 8| 9| 7| 0| 0| 0| 9| 0| 3| 9| 9| 0| 4| 2| 0| 0| 9| 0| 0| 4| 9| 5| 6| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
     0 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |             3     3                                                      |             
                                            __________________________________________________________________________|             
   Penis                                   |                            +                                             |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         | 2        3  2  2  2  2           2              2     3     2     2      |             
      Duct, Cyst                           |                                           X                              |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  M     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                           4  3                           |             
      Inflammation, Chronic Active         | 3                    3  2        2     2                             2   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +  +  +  +  +  +  +  M     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    3                                                                     |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       | 2              2        2                 2        2        2     2      |             
      Seminiferous Tubule, Atrophy         | 3                       2              2                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                    +                     |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  A     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Myelofibrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  A     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  A     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  M     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  A     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Fibrosis                             |             1                          3                             3   |             
      Red Pulp, Atrophy                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  A     +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   | 4  3        3        2           2        3  2  2     3           4  4   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  M     +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |    3  2  2  1  2  2  3  2        2        3     2  2  2  2  2  2  3  3  1|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 4| 7| 7| 5| 0| 0| 7| 1| 7| 7| 7| 7| 4| 7| 1| 4| 1| 6| 6| 1|             
                             DAY ON TEST   | 1| 2| 1| 3| 3| 6| 2| 3| 4| 5| 5| 3| 8| 1| 3| 3| 2| 6| 3| 8| 5| 8| 5| 6| 8|             
                                           | 8| 9| 7| 0| 0| 0| 9| 0| 3| 9| 9| 0| 4| 2| 0| 0| 9| 0| 0| 4| 9| 5| 6| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
     0 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Humerus, Fibrous Osteodystrophy      |                                                                      1   |             
      Humerus, Osteosclerosis              |                                                                          |             
      Humerus, Joint, Cartilage,           |                                                                          |             
          Degeneration, Focal              |                                                                          |             
      Humerus, Joint, Cartilage,           |                                                                          |             
          Degeneration                     |                                                                          |             
      Humerus, Joint, Cartilage, Necrosis, |                                                                          |             
           Focal                           |                      3                                                   |             
      Humerus, Ligament, Metaplasia,       |                                                                          |             
          Cartilagenous, Focal             |                                                                          |             
      Joint, Cartilage, Tibia, Necrosis,   |                                                                          |             
           Focal                           |                                                                          |             
      Mandible, Fibrous Osteodystrophy     |                                                                          |             
      Maxilla, Fibrous Osteodystrophy      |                                                                      3   |             
      Thoracic, Periosteum, Vertebra,      |                                                                          |             
          Hyperostosis                     |                                        3                                 |             
      Thoracic, Vertebra, Fibrous          |                                                                          |             
          Osteodystrophy                   |                   1                                                      |             
      Thoracic, Vertebra, Intervertebral   |                                                                          |             
          Disc, Degeneration               |                                        3                                 |             
      Tibia, Fibrous Osteodystrophy        |                      1                                               3   |             
      Tibia, Osteosclerosis                |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |       X                                                                  |             
      Degeneration                         |                                                                          |             
      Hydrocephalus                        |       2                                                                  |             
      Necrosis, Subacute                   |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                      2                                                   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                    2                     |             
      Metaplasia, Squamous                 |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 4| 7| 7| 5| 0| 0| 7| 1| 7| 7| 7| 7| 4| 7| 1| 4| 1| 6| 6| 1|             
                             DAY ON TEST   | 1| 2| 1| 3| 3| 6| 2| 3| 4| 5| 5| 3| 8| 1| 3| 3| 2| 6| 3| 8| 5| 8| 5| 6| 8|             
                                           | 8| 9| 7| 0| 0| 0| 9| 0| 3| 9| 9| 0| 4| 2| 0| 0| 9| 0| 0| 4| 9| 5| 6| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
     0 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Mucosa, Inflammation, Chronic Active | 3        3  2                          2  3  3                       2   |             
      Mucosa, Ulcer                        |                                                                      2   |             
      Sinus, Foreign Body                  | 3        3  2                          2  3  3                       2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  A     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Pinna, Acanthosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +     +  +  +  +  +                                                   |             
      Lens, Cataract                       | 4  3     3  3  2  3  3                                                   |             
      Retina, Atrophy                      | 4  4     4  4  3  4  4                                                   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  A     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 4  4  2  3  3  3  4  4  2        4     3  4  4  3  3  4  1  3  1  4  4  1|             
      Cortex, Cyst                         |                                  X           X                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  A     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 6| 7| 7| 1| 7| 7| 1| 7| 1| 7| 4| 7| 7| 1| 6| 6| 5| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 5| 8| 2| 3| 8| 2| 3| 8| 3| 8| 2| 6| 2| 2| 8| 7| 9| 7| 1| 3|             
                                           | 8| 0| 1| 1| 1| 9| 6| 9| 1| 5| 9| 1| 4| 1| 5| 9| 0| 6| 9| 4| 6| 2| 1| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
     0 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Congestion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                        X     X  X                        |             
      Clear Cell Focus                     |    X                             X     X     X        X                  |             
      Eosinophilic Focus                   |             X                                                            |             
      Hepatodiaphragmatic Nodule           |          X                    X                                          |             
      Hyperplasia                          |                         3                                                |             
      Inflammation, Chronic Active         |                2                                1        2               |             
      Vacuolization Cytoplasmic            |                3        3     1                 2           3     4  2   |             
      Bile Duct, Hyperplasia               | 3     2  3  2     3  3        2  3     4     3  2  2  3     3  2     4   |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                                                                          |             
      Hepatocyte, Degeneration, Cystic     |                                                    2        3           2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                                  +   |             
      Fat, Inflammation, Chronic Active    |                   3                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |          3     2     2           3  1     1           3  2               |             
      Acinus, Hyperplasia                  |                                                                          |             
      Artery, Inflammation, Chronic Active |                                        3           3                     |             
      Vein, Thrombosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                   2                                               3      |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         | 4                                                                        |             
      Mineralization                       |                                                    4                     |             
      Ulcer                                | 3                       2                                            3   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dysplasia                            |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Mineralization                       |                         3                          3                     |             
      Necrosis                             | 3                 2                                                      |             
      Ulcer                                |                         3                                      3         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 6| 7| 7| 1| 7| 7| 1| 7| 1| 7| 4| 7| 7| 1| 6| 6| 5| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 5| 8| 2| 3| 8| 2| 3| 8| 3| 8| 2| 6| 2| 2| 8| 7| 9| 7| 1| 3|             
                                           | 8| 0| 1| 1| 1| 9| 6| 9| 1| 5| 9| 1| 4| 1| 5| 9| 0| 6| 9| 4| 6| 2| 1| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
     0 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dentine, Incisor, Dysplasia          |                                                    2                     |             
      Dentine, Incisor, Necrosis,          |                                                                          |             
          Multifocal                       | 1  1  2  1  1     1  1  1     1  1     1     1     1  1     1  1  1  1  1|             
      Peridontal Tissue, Molar,            |                                                                          |             
          Inflammation, Chronic,           |                                                                          |             
          Suppurative                      |                                                                          |             
      Peridontal Tissue, Molar,            |                                                                          |             
          Inflammation, Suppurative        |                4                                                         |             
      Peridontal Tissue, Molar, Lower,     |                                                                          |             
           Inflammation, Chronic,          |                                                                          |             
          Suppurative                      |    3     3        4           2  3                                2      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                    +                     |             
      Aorta, Mineralization                |                                                    3                     |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Chronic                | 2  2  1  2  3  2  3  2  2     2  2  1  1  1  3  1  3  3  1  3  2     2  3|             
      Mineralization                       |                                                    3                     |             
      Thrombosis                           |                                                       X     X            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                               2        2     2                          2|             
      Vacuolization Cytoplasmic, Focal     |                   2     3                                      2         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |             2                          2     2     3  2           2  1  1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   2                                                      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Congestion            |                                                                          |             
      Pars Distalis, Cyst                  |                X                          X                              |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                 1                 3      |             
      Pars Distalis, Inflammation, Chronic |                                                                          |             
          Active                           |                                                                4         |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 6| 7| 7| 1| 7| 7| 1| 7| 1| 7| 4| 7| 7| 1| 6| 6| 5| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 5| 8| 2| 3| 8| 2| 3| 8| 3| 8| 2| 6| 2| 2| 8| 7| 9| 7| 1| 3|             
                                           | 8| 0| 1| 1| 1| 9| 6| 9| 1| 5| 9| 1| 4| 1| 5| 9| 0| 6| 9| 4| 6| 2| 1| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
     0 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         | 2  2  2  2  2  1  3  2        2  2     2     2  2  2  2              2  2|             
      Duct, Cyst                           |                   X                                                      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                        3                                 |             
      Inflammation, Chronic Active         |          2              2     1  1           1                 2        2|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       | 2              2              2                 2  2        2  2         |             
      Seminiferous Tubule, Atrophy         | 3        2                                         3              4  3   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Myelofibrosis               |                                                    3                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              3                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Fibrosis                             |          3           2           2                                       |             
      Red Pulp, Atrophy                    |                                                             3            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  M  +  +  +|             
      Depletion Lymphoid                   | 3  3  2  3  2           3     2  2     2     2              3           4|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2  2  2  3  2  2  2  2  3  2  2  2  1  2  1  2  3  3  2  2  2  4  2  3  2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 6| 7| 7| 1| 7| 7| 1| 7| 1| 7| 4| 7| 7| 1| 6| 6| 5| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 5| 8| 2| 3| 8| 2| 3| 8| 3| 8| 2| 6| 2| 2| 8| 7| 9| 7| 1| 3|             
                                           | 8| 0| 1| 1| 1| 9| 6| 9| 1| 5| 9| 1| 4| 1| 5| 9| 0| 6| 9| 4| 6| 2| 1| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
     0 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Humerus, Fibrous Osteodystrophy      | 2                                                  3                     |             
      Humerus, Osteosclerosis              |                                        3                             2   |             
      Humerus, Joint, Cartilage,           |                                                                          |             
          Degeneration, Focal              |                                                                          |             
      Humerus, Joint, Cartilage,           |                                                                          |             
          Degeneration                     |             3                                                            |             
      Humerus, Joint, Cartilage, Necrosis, |                                                                          |             
           Focal                           |                                                                          |             
      Humerus, Ligament, Metaplasia,       |                                                                          |             
          Cartilagenous, Focal             |                                                 2                        |             
      Joint, Cartilage, Tibia, Necrosis,   |                                                                          |             
           Focal                           |                                                                      4   |             
      Mandible, Fibrous Osteodystrophy     |                                                                          |             
      Maxilla, Fibrous Osteodystrophy      |                                                    3                     |             
      Thoracic, Periosteum, Vertebra,      |                                                                          |             
          Hyperostosis                     |                                                                          |             
      Thoracic, Vertebra, Fibrous          |                                                                          |             
          Osteodystrophy                   |                                                    2                     |             
      Thoracic, Vertebra, Intervertebral   |                                                                          |             
          Disc, Degeneration               |                                                                          |             
      Tibia, Fibrous Osteodystrophy        | 2                                                  3                     |             
      Tibia, Osteosclerosis                |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Degeneration                         |                                                                   2      |             
      Hydrocephalus                        |                                                                2         |             
      Necrosis, Subacute                   |                                                                      2   |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                    2                     |             
      Alveolar Epithelium, Hyperplasia     |                                                 2                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                2                                2                        |             
      Metaplasia, Squamous                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 6| 7| 7| 1| 7| 7| 1| 7| 1| 7| 4| 7| 7| 1| 6| 6| 5| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 5| 8| 2| 3| 8| 2| 3| 8| 3| 8| 2| 6| 2| 2| 8| 7| 9| 7| 1| 3|             
                                           | 8| 0| 1| 1| 1| 9| 6| 9| 1| 5| 9| 1| 4| 1| 5| 9| 0| 6| 9| 4| 6| 2| 1| 8| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
     0 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Mucosa, Inflammation, Chronic Active | 3  3                 1                 2     2                 2         |             
      Mucosa, Ulcer                        |                                                                          |             
      Sinus, Foreign Body                  | 3  3                 2                       2                 2         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |    +                                                                     |             
      Pinna, Acanthosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +     +  +  +                          +              +      |             
      Lens, Cataract                       |             3     3  3  3                          3                     |             
      Retina, Atrophy                      |             4     4  4  4                          4                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                       +                  |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                      M   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 4  4  4  3  4  2  3  4  4  1  4  4  1  4  1  4  2  4  4  1  2  3  2  2  4|             
      Cortex, Cyst                         |                                                    X                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 3| 6| 6| 7| 7| 6| 6| 7| 5| 7| 7| 1| 7| 5| 7| 6| 4| 7| 7| 6| 6| 7|             
                             DAY ON TEST   | 2| 3| 3| 2| 4| 9| 3| 3| 1| 4| 3| 9| 3| 1| 8| 3| 4| 1| 9| 4| 3| 3| 6| 4| 3|             
                                           | 9| 1| 2| 5| 4| 7| 2| 2| 3| 5| 2| 9| 2| 9| 4| 2| 3| 9| 0| 1| 2| 2| 5| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
     0 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X     X                    X              X              X  X         |             
      Clear Cell Focus                     | X  X  X           X                                         X           X|             
      Eosinophilic Focus                   |                   X                                                      |             
      Hepatodiaphragmatic Nodule           | X                                                              X         |             
      Hyperplasia                          |                      3              3                                    |             
      Inflammation, Chronic Active         |          1                                2                    2         |             
      Vacuolization Cytoplasmic            | 1        2  4     2        4           3        2     2     2     4  4   |             
      Bile Duct, Hyperplasia               | 1  2  3  2  2  2  2  2  4  2  2  3     2     3     2  2     3  2  2  3  2|             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                                           2                              |             
      Hepatocyte, Degeneration, Cystic     |                   2  2                                      2            |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                    +  +                                   +  +      |             
      Fat, Inflammation, Chronic Active    |    3                    3  3                                   3  3      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      | 2              2        2  2        2        2           3     3         |             
      Acinus, Hyperplasia                  |                                                                          |             
      Artery, Inflammation, Chronic Active |                   2                                                      |             
      Vein, Thrombosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           | 3                                                                        |             
      Inflammation, Acute                  |                                                                   2      |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
      Ulcer                                |             3                                         2              2   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dysplasia                            |                                                                          |             
      Hyperplasia                          |    2                                                                     |             
      Mineralization                       |                                              3                           |             
      Necrosis                             |                            2                                             |             
      Ulcer                                |             3                                         2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 3| 6| 6| 7| 7| 6| 6| 7| 5| 7| 7| 1| 7| 5| 7| 6| 4| 7| 7| 6| 6| 7|             
                             DAY ON TEST   | 2| 3| 3| 2| 4| 9| 3| 3| 1| 4| 3| 9| 3| 1| 8| 3| 4| 1| 9| 4| 3| 3| 6| 4| 3|             
                                           | 9| 1| 2| 5| 4| 7| 2| 2| 3| 5| 2| 9| 2| 9| 4| 2| 3| 9| 0| 1| 2| 2| 5| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
     0 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dentine, Incisor, Dysplasia          |                                                                          |             
      Dentine, Incisor, Necrosis,          |                                                                          |             
          Multifocal                       | 1  1  1     1  1  1  1  1  1  2  1  2  1     1  1  1  1     1  1  1  1  1|             
      Peridontal Tissue, Molar,            |                                                                          |             
          Inflammation, Chronic,           |                                                                          |             
          Suppurative                      |                                                                          |             
      Peridontal Tissue, Molar,            |                                                                          |             
          Inflammation, Suppurative        |                                                                          |             
      Peridontal Tissue, Molar, Lower,     |                                                                          |             
           Inflammation, Chronic,          |                                                                          |             
          Suppurative                      |       2     2  3     2           3  2                                   3|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Chronic                | 2  2  2  3  3  3  2  2  3  3  1  3  2  2  2        3  2  3  2  2  2  3  2|             
      Mineralization                       |                                                                          |             
      Thrombosis                           |             X                                         X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |    X                                                                     |             
      Hemorrhage                           |                         3                                                |             
      Hyperplasia                          |    2                                                                     |             
      Vacuolization Cytoplasmic, Focal     |                                                                2         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |    2                 2        2     3              2     2  1  3  3  3   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                              3                           |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Congestion            |                   3                                                     3|             
      Pars Distalis, Cyst                  |                               X                                          |             
      Pars Distalis, Hemorrhage            |                                                                          |             
      Pars Distalis, Hyperplasia           | 2                          2        2              2           2         |             
      Pars Distalis, Inflammation, Chronic |                                                                          |             
          Active                           |                                                                          |             
      Pars Intermedia, Cyst                |                            X                                             |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 3| 6| 6| 7| 7| 6| 6| 7| 5| 7| 7| 1| 7| 5| 7| 6| 4| 7| 7| 6| 6| 7|             
                             DAY ON TEST   | 2| 3| 3| 2| 4| 9| 3| 3| 1| 4| 3| 9| 3| 1| 8| 3| 4| 1| 9| 4| 3| 3| 6| 4| 3|             
                                           | 9| 1| 2| 5| 4| 7| 2| 2| 3| 5| 2| 9| 2| 9| 4| 2| 3| 9| 0| 1| 2| 2| 5| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
     0 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Hyperplasia                  |                                                 1           2  2         |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         | 2  2        3  2     2  2  2  2     3        3     2              2      |             
      Duct, Cyst                           |                                                    X                     |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 3                                                                        |             
      Inflammation, Chronic Active         |    1  2        2  2  3        2              2  1                       3|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       | 2        1           2  2  2  2  2           2  2     2  1               |             
      Seminiferous Tubule, Atrophy         |             3  2              2     3        2                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Myelofibrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                          3               |             
      Fibrosis                             |                                                             2        2  2|             
      Red Pulp, Atrophy                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Depletion Lymphoid                   | 2  3  3     3  3  3  4     3  2  2  3        3     3  3  3  2  4  3  3   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  | 2  2  2     3     3  3  2  3  2  3  2  2  2  3  3     3  3     2  3     3|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 3| 6| 6| 7| 7| 6| 6| 7| 5| 7| 7| 1| 7| 5| 7| 6| 4| 7| 7| 6| 6| 7|             
                             DAY ON TEST   | 2| 3| 3| 2| 4| 9| 3| 3| 1| 4| 3| 9| 3| 1| 8| 3| 4| 1| 9| 4| 3| 3| 6| 4| 3|             
                                           | 9| 1| 2| 5| 4| 7| 2| 2| 3| 5| 2| 9| 2| 9| 4| 2| 3| 9| 0| 1| 2| 2| 5| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
     0 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Humerus, Fibrous Osteodystrophy      |                                     1                                    |             
      Humerus, Osteosclerosis              |                         1                                                |             
      Humerus, Joint, Cartilage,           |                                                                          |             
          Degeneration, Focal              |                                                                          |             
      Humerus, Joint, Cartilage,           |                                                                          |             
          Degeneration                     |                                                                          |             
      Humerus, Joint, Cartilage, Necrosis, |                                                                          |             
           Focal                           |                                                                          |             
      Humerus, Ligament, Metaplasia,       |                                                                          |             
          Cartilagenous, Focal             |                                                                          |             
      Joint, Cartilage, Tibia, Necrosis,   |                                                                          |             
           Focal                           |                                                                          |             
      Mandible, Fibrous Osteodystrophy     |                                                                          |             
      Maxilla, Fibrous Osteodystrophy      |                                              1                           |             
      Thoracic, Periosteum, Vertebra,      |                                                                          |             
          Hyperostosis                     |                                                                          |             
      Thoracic, Vertebra, Fibrous          |                                                                          |             
          Osteodystrophy                   |                                              1                           |             
      Thoracic, Vertebra, Intervertebral   |                                                                          |             
          Disc, Degeneration               |                                                                          |             
      Tibia, Fibrous Osteodystrophy        | 1                                            1                           |             
      Tibia, Osteosclerosis                |                      2  1                                                |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Degeneration                         |                                                                          |             
      Hydrocephalus                        |                                                                          |             
      Necrosis, Subacute                   |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |          +                                                               |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                         2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Squamous                 |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 3| 6| 6| 7| 7| 6| 6| 7| 5| 7| 7| 1| 7| 5| 7| 6| 4| 7| 7| 6| 6| 7|             
                             DAY ON TEST   | 2| 3| 3| 2| 4| 9| 3| 3| 1| 4| 3| 9| 3| 1| 8| 3| 4| 1| 9| 4| 3| 3| 6| 4| 3|             
                                           | 9| 1| 2| 5| 4| 7| 2| 2| 3| 5| 2| 9| 2| 9| 4| 2| 3| 9| 0| 1| 2| 2| 5| 8| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
     0 PPM                                 | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Mucosa, Inflammation, Chronic Active | 3                             3                       3  4           2  3|             
      Mucosa, Ulcer                        |                                                                          |             
      Sinus, Foreign Body                  | 3                             3                       3                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                              +                           |             
      Pinna, Acanthosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                 +  +                                                   |             
      Lens, Cataract                       | 3                 3  3                                                   |             
      Retina, Atrophy                      | 4                 4  4                                                   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 4  3  4  2  3  3  3  3  2  4  2  3  4  3  1  4  2  4  2  2  3  4  3  2  4|             
      Cortex, Cyst                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 5| 7| 6| 7| 7| 7| 6| 5| 7| 5| 7| 7| 4| 7| 7| 4| 4| 6| 5| 5| 6| 7| 1| 4|            |
                             DAY ON TEST   | 4| 7| 3| 7| 3| 3| 2| 4| 7| 1| 3| 3| 3| 5| 3| 2| 5| 5| 8| 4| 4| 9| 3| 8| 5|            |
                                           | 5| 0| 3| 7| 3| 3| 9| 6| 0| 6| 3| 3| 3| 9| 3| 9| 9| 9| 4| 9| 3| 4| 3| 5| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
     0 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  98        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  98        |
      Congestion                           |                         4                                                |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  98        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  98        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  98        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
      Basophilic Focus                     |       X        X                    X     X  X                           |     18     |
      Clear Cell Focus                     |             X  X                    X     X  X                           |     23     |
      Eosinophilic Focus                   |                X                                               X         |      5     |
      Hepatodiaphragmatic Nodule           |                                                                          |      7     |
      Hyperplasia                          |                                                                          |      4  3.0|
      Inflammation, Chronic Active         |                                        1        2  1                    1|     13  1.4|
      Vacuolization Cytoplasmic            |                         2  3  2        2        2  3  3  3  3           2|     32  2.6|
      Bile Duct, Hyperplasia               |       3  3  4  2  4  2  3  4  2  3  2  2  3  3  2  2  3     2     3     2|     73  2.5|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |                                                                          |      1  2.0|
      Hepatocyte, Degeneration, Cystic     |       2     2                                                  2  2      |     13  2.2|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                    +                       +                  |  13        |
      Fat, Inflammation, Chronic Active    |          4                    3                       3                  |     12  3.1|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  98        |
      Acinus, Atrophy                      |    2  3     2  1        2  2     2                 1  2        2        4|     34  2.2|
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic Active |                                     3                                    |      5  2.8|
      Vein, Thrombosis                     |                            X                                             |      1     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  98        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  98        |
      Acanthosis                           |    3        3                 3                                3         |      9  2.8|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |    3                                                                     |      3  3.0|
      Mineralization                       |                                                                          |      1  4.0|
      Ulcer                                |    3                                                                     |      8  2.6|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  98        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  84                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 5| 7| 6| 7| 7| 7| 6| 5| 7| 5| 7| 7| 4| 7| 7| 4| 4| 6| 5| 5| 6| 7| 1| 4|            |
                             DAY ON TEST   | 4| 7| 3| 7| 3| 3| 2| 4| 7| 1| 3| 3| 3| 5| 3| 2| 5| 5| 8| 4| 4| 9| 3| 8| 5|            |
                                           | 5| 0| 3| 7| 3| 3| 9| 6| 0| 6| 3| 3| 3| 9| 3| 9| 9| 9| 4| 9| 3| 4| 3| 5| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
     0 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Dysplasia                            | 2                                                                        |      2  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      3  3.0|
      Necrosis                             |          2                                                               |      4  2.3|
      Ulcer                                |                         2                                                |      7  2.6|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
      Dentine, Incisor, Dysplasia          |                1                                                         |      4  1.3|
      Dentine, Incisor, Necrosis,          |                                                                          |            |
          Multifocal                       |    2  1  1  1  1  1  1  1  1  1  2  1     1  1        1  1  1  1  1      |     75  1.1|
      Peridontal Tissue, Molar,            |                                                                          |            |
          Inflammation, Chronic,           |                                                                          |            |
          Suppurative                      |          3                                                               |      1  3.0|
      Peridontal Tissue, Molar,            |                                                                          |            |
          Inflammation, Suppurative        |                                        4                                 |      4  4.0|
      Peridontal Tissue, Molar, Lower,     |                                                                          |            |
           Inflammation, Chronic,          |                                                                          |            |
          Suppurative                      |       2     2  4  3  2     3  3  4        3           3  3     3         |     27  2.7|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Aorta, Mineralization                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
      Degeneration, Chronic                |    2  2  1  2  2  3  2  3  2  2  2  2  2  3  3  3  2  2     3  2  2  2  3|     91  2.2|
      Mineralization                       |                                                             3            |      2  3.0|
      Thrombosis                           |             X              X                                             |      6     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1     |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia                          |                                  2                                       |     10  2.2|
      Vacuolization Cytoplasmic, Focal     |                      3                                   2               |      6  2.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  98        |
      Hemorrhage                           |                         3                                                |      1  3.0|
      Hyperplasia                          |    1  2  2  2  2        2  2     2                    2           1      |     33  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  98        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  96        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  85                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 5| 7| 6| 7| 7| 7| 6| 5| 7| 5| 7| 7| 4| 7| 7| 4| 4| 6| 5| 5| 6| 7| 1| 4|            |
                             DAY ON TEST   | 4| 7| 3| 7| 3| 3| 2| 4| 7| 1| 3| 3| 3| 5| 3| 2| 5| 5| 8| 4| 4| 9| 3| 8| 5|            |
                                           | 5| 0| 3| 7| 3| 3| 9| 6| 0| 6| 3| 3| 3| 9| 3| 9| 9| 9| 4| 9| 3| 4| 3| 5| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
     0 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
      Pars Distalis, Congestion            |                                                                          |      2  3.0|
      Pars Distalis, Cyst                  |                                           X                              |      6     |
      Pars Distalis, Hemorrhage            |                                                                          |      3  3.0|
      Pars Distalis, Hyperplasia           |                2                       1  2                             2|     17  2.2|
      Pars Distalis, Inflammation, Chronic |                                                                          |            |
          Active                           |                                                                          |      1  4.0|
      Pars Intermedia, Cyst                |             X     X                                                      |      3     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
      C-Cell, Hyperplasia                  |                   2                          2                           |      5  1.8|
      Follicle, Cyst                       |                            X                                      X      |      2     |
      Follicular Cell, Hyperplasia         |                            2                                   2         |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                      +   |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
      Dilatation                           |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
      Hyperplasia                          |                                                 3                        |      1  3.0|
      Inflammation, Chronic Active         |    2  2     2     2        2  2  2        1  2     1  2        2  2     2|     54  2.1|
      Duct, Cyst                           |                                                       X                  |      4     |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  98        |
      Dilatation                           |                                                                          |      4  3.3|
      Inflammation, Chronic Active         |       2  3  1           2     2           1                       2      |     29  1.9|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  97        |
      Atrophy                              |                                                             3            |      2  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
      Interstitial Cell, Hyperplasia       |    2  2     2        2  2     2        2        2  2  2  1  2  2        2|     39  1.9|
      Seminiferous Tubule, Atrophy         |          3              3  2  2                       2     3  3         |     20  2.6|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  98        |
      Femoral, Myelofibrosis               |    2                                                                     |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  98        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  86                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 5| 7| 6| 7| 7| 7| 6| 5| 7| 5| 7| 7| 4| 7| 7| 4| 4| 6| 5| 5| 6| 7| 1| 4|            |
                             DAY ON TEST   | 4| 7| 3| 7| 3| 3| 2| 4| 7| 1| 3| 3| 3| 5| 3| 2| 5| 5| 8| 4| 4| 9| 3| 8| 5|            |
                                           | 5| 0| 3| 7| 3| 3| 9| 6| 0| 6| 3| 3| 3| 9| 3| 9| 9| 9| 4| 9| 3| 4| 3| 5| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
     0 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  98        |
      Angiectasis                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  97        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  98        |
      Depletion Lymphoid                   |                                                                          |      1  3.0|
      Fibrosis                             |                                  2                                       |     10  2.2|
      Red Pulp, Atrophy                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  88        |
      Depletion Lymphoid                   |    3  4  3  3  3  2              4  3     4  3        3        3         |     54  2.9|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  92        |
      Hyperplasia, Cystic                  | 2  2  3  3  2  2  2  3     3  3  2  2  2  3  2  2  2  2  4  2  3  2  2   |     87  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
      Acanthosis                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
      Humerus, Fibrous Osteodystrophy      |    3                                      1                 1  3         |      8  1.9|
      Humerus, Osteosclerosis              |       1                                                                  |      4  1.8|
      Humerus, Joint, Cartilage,           |                                                                          |            |
          Degeneration, Focal              |                                  3                                       |      1  3.0|
      Humerus, Joint, Cartilage,           |                                                                          |            |
          Degeneration                     |                                                                          |      1  3.0|
      Humerus, Joint, Cartilage, Necrosis, |                                                                          |            |
           Focal                           |                                                                          |      1  3.0|
      Humerus, Ligament, Metaplasia,       |                                                                          |            |
          Cartilagenous, Focal             |                                                                          |      1  2.0|
      Joint, Cartilage, Tibia, Necrosis,   |                                                                          |            |
           Focal                           |                                                                          |      1  4.0|
      Mandible, Fibrous Osteodystrophy     |                                                                3         |      1  3.0|
      Maxilla, Fibrous Osteodystrophy      |    2                                      1                 2  2         |      7  2.0|
      Thoracic, Periosteum, Vertebra,      |                                                                          |            |
          Hyperostosis                     |                                                                          |      1  3.0|
      Thoracic, Vertebra, Fibrous          |                                                                          |            |
          Osteodystrophy                   |    1                                      1                 1  2         |      7  1.3|
      Thoracic, Vertebra, Intervertebral   |                                                                          |            |
          Disc, Degeneration               |                                                                          |      1  3.0|
      Tibia, Fibrous Osteodystrophy        |    2                                      1                 1  3         |     10  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  87                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 5| 7| 6| 7| 7| 7| 6| 5| 7| 5| 7| 7| 4| 7| 7| 4| 4| 6| 5| 5| 6| 7| 1| 4|            |
                             DAY ON TEST   | 4| 7| 3| 7| 3| 3| 2| 4| 7| 1| 3| 3| 3| 5| 3| 2| 5| 5| 8| 4| 4| 9| 3| 8| 5|            |
                                           | 5| 0| 3| 7| 3| 3| 9| 6| 0| 6| 3| 3| 3| 9| 3| 9| 9| 9| 4| 9| 3| 4| 3| 5| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
     0 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Tibia, Osteosclerosis                |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
      Compression                          |                                                          X               |      2     |
      Degeneration                         |                                                                          |      1  2.0|
      Hydrocephalus                        |                                                                          |      2  2.0|
      Necrosis, Subacute                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
      Inflammation, Chronic Active         |                         3                                                |      1  3.0|
      Mineralization                       |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  99        |
      Inflammation, Chronic Active         |                                                    2                     |      4  2.0|
      Metaplasia, Squamous                 | 2                                                  2                     |      4  2.0|
      Mucosa, Inflammation, Chronic Active | 3     3                          3        2                    3  3      |     25  2.6|
      Mucosa, Ulcer                        |                                                                          |      1  2.0|
      Sinus, Foreign Body                  | 3     2                          3                             3  3      |     20  2.7|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  98        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                           +                              |   3        |
      Pinna, Acanthosis                    |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |       +     +  +  +     +                    +                    +      |  23        |
      Lens, Cataract                       |       3     3  3  3                          3                    3      |     21  3.0|
      Retina, Atrophy                      |       4     4  4  4     2                    4                    4      |     22  3.9|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  98        |
      Nephropathy, Chronic                 | 1  4  3  2  4  3  3  3  3  3  2  3  3  2  4  2  2  2  4  3  4  4  4  1  3|     97  3.0|
      Cortex, Cyst                         |                                                                          |      3     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  88                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 5| 7| 6| 7| 7| 7| 6| 5| 7| 5| 7| 7| 4| 7| 7| 4| 4| 6| 5| 5| 6| 7| 1| 4|            |
                             DAY ON TEST   | 4| 7| 3| 7| 3| 3| 2| 4| 7| 1| 3| 3| 3| 5| 3| 2| 5| 5| 8| 4| 4| 9| 3| 8| 5|            |
                                           | 5| 0| 3| 7| 3| 3| 9| 6| 0| 6| 3| 3| 3| 9| 3| 9| 9| 9| 4| 9| 3| 4| 3| 5| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
     0 PPM                                 | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  98        |
      Calculus Micro Observation Only      |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  89                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 6| 7| 4| 5| 7| 6| 5| 5| 5| 1| 6| 5| 5| 7| 7| 7| 6| 5| 3| 6| 7| 6|             
                             DAY ON TEST   | 6| 7| 2| 2| 3| 0| 4| 1| 7| 9| 5| 3| 8| 2| 8| 6| 3| 3| 1| 5| 3| 8| 0| 3| 8|             
                                           | 4| 7| 6| 0| 0| 4| 4| 6| 0| 1| 5| 7| 0| 7| 4| 1| 1| 2| 0| 5| 3| 8| 2| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    SPECIAL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Ulcer                                |                                                                         2|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Ulcer                                |                                        3                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Angiectasis                          |    4                    3                                                |             
      Basophilic Focus                     |                      X                 X                       X         |             
      Clear Cell Focus                     |                                                       X                  |             
      Eosinophilic Focus                   |                      X                                                   |             
      Hepatodiaphragmatic Nodule           |                   X              X     X                 X               |             
      Hyperplasia                          |       3                                                                  |             
      Inflammation, Chronic Active         |                   2                                            1         |             
      Vacuolization Cytoplasmic            | 2              3  2        2              3  2           2     3  3     2|             
      Bile Duct, Hyperplasia               | 2  4  3  3     1  2     3  1  2  2     2  3  2        2  2  2  1  3     4|             
      Hepatocyte, Degeneration, Cystic     |       2                                                                 2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                   +     +|             
      Fat, Hemorrhage                      |                                                                          |             
      Fat, Inflammation, Chronic Active    |                                                                   2     3|             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Acinus, Atrophy                      | 2  3  4  1           2  2        3     3              1        1         |             
      Acinus, Hyperplasia                  |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                          3               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Acanthosis                           |    3                                                                     |             
      Inflammation, Chronic Active         |                                  2                                       |             
      Ulcer                                |                                  2                                      3|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                  2                                      3|             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Dentine, Incisor, Necrosis,          |                                                                          |             
          Multifocal                       | 1  1  1  1        1  1  1  1  1  1     3  1  1        1  1        1     1|             
      Peridontal Tissue, Molar, Lower,     |                                                                          |             
           Inflammation, Chronic,          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 6| 7| 4| 5| 7| 6| 5| 5| 5| 1| 6| 5| 5| 7| 7| 7| 6| 5| 3| 6| 7| 6|             
                             DAY ON TEST   | 6| 7| 2| 2| 3| 0| 4| 1| 7| 9| 5| 3| 8| 2| 8| 6| 3| 3| 1| 5| 3| 8| 0| 3| 8|             
                                           | 4| 7| 6| 0| 0| 4| 4| 6| 0| 1| 5| 7| 0| 7| 4| 1| 1| 2| 0| 5| 3| 8| 2| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    SPECIAL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
          Suppurative                      |       3  3        3  3  2     4  3     3              3     2            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Degeneration, Chronic                | 1  3  3  3     3     3  2     3     2  2  3  3        1  2  2  2  3     3|             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Hyperplasia                          |                                                                   2      |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Hyperplasia                          |    2     2     1        3        1                    1                 2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +     +  +  +  +  +  +  +  +  +  +  M        +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Pars Distalis, Cyst                  |                                              X                           |             
      Pars Distalis, Hyperplasia           |          3           2                 2                 2               |             
      Pars Intermedia, Cyst                |       X                             X                                    |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      C-Cell, Hyperplasia                  |          2        2                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ductus Deferens                         |                         +                                                |             
      Hemorrhage                           |                         4                                                |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Hemorrhage                           |                         4                                                |             
      Inflammation, Chronic Active         |                         3                                                |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Hyperplasia, Glandular               |    2                                                                     |             
      Inflammation, Chronic Active         | 2     2        1  2  2  2  2  2     2  3  2           2  2  1  2  2      |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Inflammation, Chronic Active         |          2        1        1     1     2  2  2                          3|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Interstitial Cell, Hyperplasia       | 2     2  2     2  2        2     2     2  2  2              2  2  2     2|             
      Seminiferous Tubule, Atrophy         |       2              3  3              3                                 |             
      Serosa, Inflammation, Chronic Active |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  91                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 6| 7| 4| 5| 7| 6| 5| 5| 5| 1| 6| 5| 5| 7| 7| 7| 6| 5| 3| 6| 7| 6|             
                             DAY ON TEST   | 6| 7| 2| 2| 3| 0| 4| 1| 7| 9| 5| 3| 8| 2| 8| 6| 3| 3| 1| 5| 3| 8| 0| 3| 8|             
                                           | 4| 7| 6| 0| 0| 4| 4| 6| 0| 1| 5| 7| 0| 7| 4| 1| 1| 2| 0| 5| 3| 8| 2| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    SPECIAL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Mediastinal, Depletion Lymphoid      |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                                       3                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Infiltration Cellular, Histiocyte    |                                                       3                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Infiltration Cellular, Histiocyte    |                                                       3                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Depletion Lymphoid                   |                                                                          |             
      Fibrosis                             |       2                                                                  |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
      Capsule, Cyst, Multiple              |    X                                                                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Depletion Lymphoid                   |    3  3  2           2     2           3              3  3        2     4|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Hyperplasia, Cystic                  | 2  1  2  2     2  3     3  3     3  3  3  2  1        1     2  2  2     3|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Hyperkeratosis                       |                                                                         4|             
      Subcutaneous Tissue, Foreign Body    |                                                                         4|             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                         4|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Humerus, Fibrous Osteodystrophy      |    2                                                                     |             
      Humerus, Osteosclerosis              |                                                                          |             
      Mandible, Fibrous Osteodystrophy     |    2                                                                     |             
      Maxilla, Fibrous Osteodystrophy      |    2                                                                     |             
      Thoracic, Vertebra, Fibrous          |                                                                          |             
          Osteodystrophy                   |    3                                                                     |             
      Tibia, Fibrous Osteodystrophy        |    3  2                                                                  |             
      Tibia, Osteosclerosis                |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Compression                          |                               X                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  92                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 6| 7| 4| 5| 7| 6| 5| 5| 5| 1| 6| 5| 5| 7| 7| 7| 6| 5| 3| 6| 7| 6|             
                             DAY ON TEST   | 6| 7| 2| 2| 3| 0| 4| 1| 7| 9| 5| 3| 8| 2| 8| 6| 3| 3| 1| 5| 3| 8| 0| 3| 8|             
                                           | 4| 7| 6| 0| 0| 4| 4| 6| 0| 1| 5| 7| 0| 7| 4| 1| 1| 2| 0| 5| 3| 8| 2| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    SPECIAL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Sciatic, Degeneration                |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                                     4  3                                 |             
      Alveolar Epithelium, Hyperplasia     |                                              2                           |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Metaplasia, Squamous                 |                                                                          |             
      Mucosa, Inflammation, Acute          |                   3           3  2     3     2                           |             
      Mucosa, Inflammation, Chronic Active |                                                       2  2              2|             
      Mucosa, Ulcer                        |                   2           3                                          |             
      Sinus, Foreign Body                  |                                                       2  2              3|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                       +                  |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +  +  +                                             |             
      Lens, Cataract                       |                      3  2  2                                             |             
      Retina, Atrophy                      |                      4  4  4                                             |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                         +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
      Nephropathy, Chronic                 | 2  4  3  2     3  2  3  3  4  2  2  1  3  2  3        2  3  1  2  4     4|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 4| 5| 7| 3| 6| 4| 6| 6| 5| 6| 6| 6| 4| 7| 6| 2| 3| 5| 3| 5| 5| 6| 6|            |
                             DAY ON TEST   | 1| 7| 2| 2| 3| 1| 3| 1| 4| 6| 7| 9| 0| 1| 4| 0| 4| 8| 8| 3| 8| 2| 0| 4| 9|            |
                                           | 3| 5| 2| 2| 3| 7| 4| 4| 5| 0| 0| 5| 7| 4| 1| 5| 4| 2| 2| 7| 9| 6| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    SPECIAL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Angiectasis                          |                                                                          |      2  3.5|
      Basophilic Focus                     |                                              X                       X   |      5     |
      Clear Cell Focus                     |                                                          X               |      2     |
      Eosinophilic Focus                   |                                                                          |      1     |
      Hepatodiaphragmatic Nodule           | X        X                                                               |      6     |
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                    1                     |      3  1.3|
      Vacuolization Cytoplasmic            | 4  2  3  2     2     2     3  2  4     2  3     2  3  3        3  3  1  2|     28  2.5|
      Bile Duct, Hyperplasia               | 4  2  3           3     3     2  3  3  2  2  2  3     2  2  2  2  2     2|     37  2.4|
      Hepatocyte, Degeneration, Cystic     |                                              2                           |      3  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                       +     +     +                     |   6        |
      Fat, Hemorrhage                      |                3                                                         |      1  3.0|
      Fat, Inflammation, Chronic Active    |                                              3     3                     |      4  2.8|
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Acinus, Atrophy                      |    2  2  2                          1              1           2  1     2|     18  1.9|
      Acinus, Hyperplasia                  |                                              3                           |      1  3.0|
      Artery, Inflammation, Chronic Active |                                              3                           |      2  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Acanthosis                           |                                  3                                       |      2  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Ulcer                                |                                  3                                       |      3  2.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Mineralization                       |                      4                                                   |      1  4.0|
      Ulcer                                |                                  3                                       |      3  2.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  94                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 4| 5| 7| 3| 6| 4| 6| 6| 5| 6| 6| 6| 4| 7| 6| 2| 3| 5| 3| 5| 5| 6| 6|            |
                             DAY ON TEST   | 1| 7| 2| 2| 3| 1| 3| 1| 4| 6| 7| 9| 0| 1| 4| 0| 4| 8| 8| 3| 8| 2| 0| 4| 9|            |
                                           | 3| 5| 2| 2| 3| 7| 4| 4| 5| 0| 0| 5| 7| 4| 1| 5| 4| 2| 2| 7| 9| 6| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    SPECIAL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Dentine, Incisor, Necrosis,          |                                                                          |            |
          Multifocal                       | 1  1     1        1     1     1  1  1  1     1  1        1     1  1  1  1|     33  1.1|
      Peridontal Tissue, Molar, Lower,     |                                                                          |            |
           Inflammation, Chronic,          |                                                                          |            |
          Suppurative                      |          3        3        4  3  3  4  3  4  4  4              3  3      |     22  3.2|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Degeneration, Chronic                |    2  3  2     2     4     2  3  2        2  2  2  2  2  3  1     3  2   |     35  2.4|
      Mineralization                       |                      4                                                   |      1  4.0|
      Thrombosis                           |                                        X                                 |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Hyperplasia                          |                                                       2                 2|      3  2.0|
      Vacuolization Cytoplasmic, Focal     |                                                                2         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Hyperplasia                          |                   2              2     2                 2               |     11  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +     M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +     +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Pars Distalis, Cyst                  |                               X                                          |      2     |
      Pars Distalis, Hyperplasia           |                            2                    3                        |      6  2.3|
      Pars Intermedia, Cyst                |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      C-Cell, Hyperplasia                  |                                           2                              |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ductus Deferens                         |                                                                          |   1        |
      Hemorrhage                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                  3                                       |      2  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  95                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 4| 5| 7| 3| 6| 4| 6| 6| 5| 6| 6| 6| 4| 7| 6| 2| 3| 5| 3| 5| 5| 6| 6|            |
                             DAY ON TEST   | 1| 7| 2| 2| 3| 1| 3| 1| 4| 6| 7| 9| 0| 1| 4| 0| 4| 8| 8| 3| 8| 2| 0| 4| 9|            |
                                           | 3| 5| 2| 2| 3| 7| 4| 4| 5| 0| 0| 5| 7| 4| 1| 5| 4| 2| 2| 7| 9| 6| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    SPECIAL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Glandular               |                                                                          |      1  2.0|
      Inflammation, Chronic Active         | 2              1        2     2  2  2  2        2  2  2     1     3  2  2|     30  1.9|
      Duct, Cyst                           |                                              X                           |      1     |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Inflammation, Chronic Active         |    2              1        2                                             |     11  1.7|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Interstitial Cell, Hyperplasia       |    2  2  2        2  2  2  2  2           2           2  2  1  2  2  2  2|     30  2.0|
      Seminiferous Tubule, Atrophy         | 3                                                                        |      5  2.8|
      Serosa, Inflammation, Chronic Active |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Mediastinal, Depletion Lymphoid      |                                  3                                       |      1  3.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Depletion Lymphoid                   |                      2                                                   |      1  2.0|
      Fibrosis                             |                                        3                                 |      2  2.5|
      Hyperplasia, Reticulum Cell          |                               4                                          |      1  4.0|
      Capsule, Cyst, Multiple              |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +     M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  43        |
      Depletion Lymphoid                   | 3  2              4        3     3  3        2           2              3|     19  2.7|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  +     M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
      Hyperplasia, Cystic                  |       3  2        2     2  2  2  4  3  2  2     2  2  2  2  3  2  2  1  2|     37  2.2|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Hyperkeratosis                       |                                                                          |      1  4.0|
      Subcutaneous Tissue, Foreign Body    |                                                                          |      1  4.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  96                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 4| 5| 7| 3| 6| 4| 6| 6| 5| 6| 6| 6| 4| 7| 6| 2| 3| 5| 3| 5| 5| 6| 6|            |
                             DAY ON TEST   | 1| 7| 2| 2| 3| 1| 3| 1| 4| 6| 7| 9| 0| 1| 4| 0| 4| 8| 8| 3| 8| 2| 0| 4| 9|            |
                                           | 3| 5| 2| 2| 3| 7| 4| 4| 5| 0| 0| 5| 7| 4| 1| 5| 4| 2| 2| 7| 9| 6| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    SPECIAL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Humerus, Fibrous Osteodystrophy      |                                  2                                       |      2  2.0|
      Humerus, Osteosclerosis              | 1                                                                        |      1  1.0|
      Mandible, Fibrous Osteodystrophy     |                                  2                                       |      2  2.0|
      Maxilla, Fibrous Osteodystrophy      |                                  2                                       |      2  2.0|
      Thoracic, Vertebra, Fibrous          |                                                                          |            |
          Osteodystrophy                   |                                                                          |      1  3.0|
      Tibia, Fibrous Osteodystrophy        |                                  2                                       |      3  2.3|
      Tibia, Osteosclerosis                | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                             +            |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Compression                          |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                         +                                                |   1        |
      Sciatic, Degeneration                |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                         +                                   +            |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Hemorrhage                           |                                                             3            |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      2  3.5|
      Alveolar Epithelium, Hyperplasia     |                                  3                                       |      2  2.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Metaplasia, Squamous                 |                                                             2            |      1  2.0|
      Mucosa, Inflammation, Acute          |    2                                   2                                 |      7  2.4|
      Mucosa, Inflammation, Chronic Active |                      2                                      2        2   |      6  2.0|
      Mucosa, Ulcer                        |                                        2                                 |      3  2.3|
      Sinus, Foreign Body                  |                                                                      3   |      4  2.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
      Lens, Cataract                       |                                                                          |      3  2.3|
      Retina, Atrophy                      |                                                                          |      3  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                  +                                       |   2        |
      Hyperplasia                          |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  97                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 4| 5| 7| 3| 6| 4| 6| 6| 5| 6| 6| 6| 4| 7| 6| 2| 3| 5| 3| 5| 5| 6| 6|            |
                             DAY ON TEST   | 1| 7| 2| 2| 3| 1| 3| 1| 4| 6| 7| 9| 0| 1| 4| 0| 4| 8| 8| 3| 8| 2| 0| 4| 9|            |
                                           | 3| 5| 2| 2| 3| 7| 4| 4| 5| 0| 0| 5| 7| 4| 1| 5| 4| 2| 2| 7| 9| 6| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    SPECIAL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Nephropathy, Chronic                 | 2  3  2  2        2  2  3  3  3  4  3  2  2  4  4  1  3  2  3  2  2  4  4|     44  2.7|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +     +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  44        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  98                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 1| 7| 7| 1| 7| 6| 6| 7| 7| 7| 7| 1| 6| 7| 7| 7| 7| 1| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 5| 8| 2| 3| 8| 2| 6| 5| 3| 3| 3| 2| 8| 6| 3| 3| 3| 1| 8| 2| 7| 4| 7| 2| 2|             
                                           | 9| 5| 9| 0| 4| 9| 8| 4| 0| 0| 0| 9| 5| 3| 1| 1| 1| 1| 4| 9| 0| 7| 6| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
     25 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
      Ulcer                                |                                                                   3      |             
      Serosa, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
      Inflammation, Chronic Active,        |                                                                          |             
          Granulomatous                    |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
      Basophilic Focus                     |       X  X     X        X  X  X  X        X  X           X        X  X  X|             
      Clear Cell Focus                     |       X        X                 X        X  X                       X  X|             
      Eosinophilic Focus                   |       X  X                                                              X|             
      Hepatodiaphragmatic Nodule           | X                       X                                                |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         | 1     2                                                                  |             
      Mixed Cell Focus                     |                                                                          |             
      Vacuolization Cytoplasmic            | 2        2        3                    4                    2     2      |             
      Bile Duct, Hyperplasia               | 2     2  1     2  3     2  1  2        2  2  2  4  2     4  4  3  3  3  2|             
      Hepatocyte, Cytomegaly, Focal        |                                                                          |             
      Hepatocyte, Degeneration, Cystic     |       2                       2  2              2                        |             
      Subserosa, Congestion                |                                                    2                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                    +     +                 +  +   |             
      Fat, Inflammation, Chronic Active    |                      3                    3     3                 2  3   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +     +  +  A  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                  1        2  2     2     2               |             
      Artery, Inflammation, Chronic Active |                2           2                                            2|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
      Acanthosis                           |                      3                                                   |             
      Ulcer                                |                   3                    3                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                   X      |             
      Necrosis                             |                                        2                                 |             
      Pigmentation, Hemosiderin            |                      2                                                   |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                      +   |             
      Mucosa, Hyperplasia, Squamous        |                                                                      4   |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  99                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 1| 7| 7| 1| 7| 6| 6| 7| 7| 7| 7| 1| 6| 7| 7| 7| 7| 1| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 5| 8| 2| 3| 8| 2| 6| 5| 3| 3| 3| 2| 8| 6| 3| 3| 3| 1| 8| 2| 7| 4| 7| 2| 2|             
                                           | 9| 5| 9| 0| 4| 9| 8| 4| 0| 0| 0| 9| 5| 3| 1| 1| 1| 1| 4| 9| 0| 7| 6| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
     25 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Dentine, Incisor, Dysplasia          |                                                 1                 1      |             
      Dentine, Incisor, Necrosis, Focal    |                                                                          |             
      Dentine, Incisor, Necrosis,          |                                                                          |             
          Multifocal                       |       1  1     1  1  1  1  1  2  1     1  1  1  1  1     1     1  1  1  1|             
      Incisor, Odontoblast, Degeneration   |                                                                          |             
      Incisor, Ameloblast, Degeneration    |                                                                          |             
      Peridontal Tissue, Molar, Lower,     |                                                                          |             
           Inflammation, Chronic,          |                                                                          |             
          Suppurative                      |          3     3     2        3           3     4        3        3      |             
      Pulp, Incisor, Inflammation, Chronic,|                                                                          |             
           Necrotizing                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
      Degeneration, Chronic                | 1     2  2     2  2  3  3  3  2  3        3  2  2  3     2     3  3  3  3|             
      Thrombosis                           |                                                                          |             
      Atrium, Dilatation                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
      Capsule, Spindle Cell, Hyperplasia   |       2                                                                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
      Hyperplasia                          |          2           2  2     1                                      2   |             
      Hypertrophy                          |                                  2                                       |             
      Vacuolization Cytoplasmic, Focal     |                                              3                           |             
      Bilateral, Degeneration, Cystic,     |                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
      Hyperplasia                          |       1                    2           1  1        1     1     4     2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +     +  +  A  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
      Hyperplasia                          |          2              2                                                |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
      Pars Distalis, Congestion            |                                  3                                       |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           | 2                                         3        3                     |             
      Pars Distalis, Vacuolization         |                                                                          |             
          Cytoplasmic, Focal               |                                                             2            |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                            2                                             |             
      Follicle, Cyst                       |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 100                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 1| 7| 7| 1| 7| 6| 6| 7| 7| 7| 7| 1| 6| 7| 7| 7| 7| 1| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 5| 8| 2| 3| 8| 2| 6| 5| 3| 3| 3| 2| 8| 6| 3| 3| 3| 1| 8| 2| 7| 4| 7| 2| 2|             
                                           | 9| 5| 9| 0| 4| 9| 8| 4| 0| 0| 0| 9| 5| 3| 1| 1| 1| 1| 4| 9| 0| 7| 6| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
     25 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
      Hyperplasia, Glandular               |       2                                                                  |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         | 2     2  2     3  2  2  2  2  2  3     2  2     2  2     2  2     2     2|             
      Duct, Cyst                           |       X           X              X                                   X   |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +  +     +  +  +  +  M  +  +     +  +  +  +  +     +  +  +  +  +  +|             
      Dilatation                           |                                                                      3   |             
      Inflammation, Chronic Active         |       2                                   1     1                 2  2   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       | 2                 2                    2        2  2                     |             
      Seminiferous Tubule, Atrophy         |       3                                3        3                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
      Femoral, Atrophy                     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Congestion                           |                                                                   3      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Inflammation, Chronic Active         |                      2                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                   3      |             
      Fibrosis                             |                               3           2     3                        |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Red Pulp, Atrophy                    |                                                    3                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +  +     +  +  +  +  +  +  +     M  +  +  +  +     +  +  +  +  +  +|             
      Depletion Lymphoid                   |       3  3     2  3  3  3  3  2  3        3  3  3  3     3  3  3  3  4  2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +  +     +  M  +  +  +  +  M     +  +  +  +  +     +  +  M  +  +  +|             
      Hyperplasia, Cystic                  | 2     1  2     2     2  2  2  2        3  1  2  2  2     2        3  3  2|             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Ulcer                                |                                                                          |             
      Sebaceous Gland, Cyst                |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 101                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 1| 7| 7| 1| 7| 6| 6| 7| 7| 7| 7| 1| 6| 7| 7| 7| 7| 1| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 5| 8| 2| 3| 8| 2| 6| 5| 3| 3| 3| 2| 8| 6| 3| 3| 3| 1| 8| 2| 7| 4| 7| 2| 2|             
                                           | 9| 5| 9| 0| 4| 9| 8| 4| 0| 0| 0| 9| 5| 3| 1| 1| 1| 1| 4| 9| 0| 7| 6| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
     25 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epiphysis, Tibia, Cyst               |                                                                      X   |             
      Epiphysis, Tibia, Cyst, Multifocal   |                                                                          |             
      Humerus, Fibrous Osteodystrophy      |                                                    1                     |             
      Humerus, Osteoporosis                |                                                                          |             
      Humerus, Osteosclerosis              |                            1                                             |             
      Humerus, Joint, Cartilage, Necrosis, |                                                                          |             
           Focal                           |                                                                      2   |             
      Humerus, Epiphysis, Cyst             |                                                                          |             
      Joint, Cartilage, Tibia, Degeneration|                                                                          |             
      Mandible, Fibrous Osteodystrophy     |                                                                          |             
      Maxilla, Fibrous Osteodystrophy      |                                                                          |             
      Thoracic, Vertebra, Fibrous          |                                                                          |             
          Osteodystrophy                   |                                                                          |             
      Tibia, Fibrous Osteodystrophy        |                                                                          |             
      Tibia, Osteoporosis                  |                                                                          |             
      Tibia, Osteosclerosis                |                                                                          |             
      Tibia, Thrombosis, Chronic, Focal    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Hydrocephalus                        |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                   3                                                      |             
      Pleura, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mucosa, Inflammation, Acute          |                                                                          |             
      Mucosa, Inflammation, Chronic Active |                      2  3  3     3        3        2     3        4      |             
      Sinus, Foreign Body                  |                      2  3  3     3        3        3     3        4      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                 +  +                                             |             
      Cornea, Hyperplasia, Squamous        |                                                                          |             
      Cornea, Inflammation, Chronic Active |                                                                          |             
      Lens, Cataract                       |       3                 3  3                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 102                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 1| 7| 7| 1| 7| 6| 6| 7| 7| 7| 7| 1| 6| 7| 7| 7| 7| 1| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 5| 8| 2| 3| 8| 2| 6| 5| 3| 3| 3| 2| 8| 6| 3| 3| 3| 1| 8| 2| 7| 4| 7| 2| 2|             
                                           | 9| 5| 9| 0| 4| 9| 8| 4| 0| 0| 0| 9| 5| 3| 1| 1| 1| 1| 4| 9| 0| 7| 6| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
     25 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Retina, Atrophy                      |       4                 4  4                                             |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                           +                              |             
      Cyst, Multiple                       |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 2     4  4     4  2  2  4  3  4  4     4  4  4  4  3     4  3  2  3  4  4|             
      Cortex, Cyst                         |                                                                      X   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +     +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 103                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 6| 7| 1| 5| 7| 1| 6| 6| 6| 7| 4| 7| 6| 5| 7| 4| 7| 7| 4| 7| 4| 6| 4| 1|             
                             DAY ON TEST   | 8| 0| 3| 8| 8| 1| 8| 6| 7| 3| 1| 5| 3| 9| 3| 2| 5| 3| 0| 5| 3| 2| 9| 5| 8|             
                                           | 5| 7| 1| 4| 4| 0| 4| 9| 1| 8| 8| 9| 2| 1| 3| 9| 9| 2| 6| 9| 2| 2| 7| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
     25 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    M  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Ulcer                                |                                                                          |             
      Serosa, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic Active,        |                                                                          |             
          Granulomatous                    |                                     4                                    |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Basophilic Focus                     |       X                       X     X           X  X                     |             
      Clear Cell Focus                     |       X        X     X              X                                    |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |                X        X                                                |             
      Hyperplasia                          |                         2                    3                    3      |             
      Inflammation, Chronic Active         |                                  2              2        1           2   |             
      Mixed Cell Focus                     |       X                                                                  |             
      Vacuolization Cytoplasmic            |    4           2        4        3     3                 2        2      |             
      Bile Duct, Hyperplasia               |    3        3        2  4        2     2  3  4  2  2     2  3  3  3  2   |             
      Hepatocyte, Cytomegaly, Focal        |                                                                          |             
      Hepatocyte, Degeneration, Cystic     |                               2     2                                    |             
      Subserosa, Congestion                |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +        +                                 |             
      Fat, Inflammation, Chronic Active    |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Acinus, Atrophy                      |    2                    2        1           2  1                        |             
      Artery, Inflammation, Chronic Active |       1                                                                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Acanthosis                           |    3                                                                     |             
      Ulcer                                |                            3                                      3      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Necrosis                             |                            2                                             |             
      Pigmentation, Hemosiderin            |                               2        2                                 |             
      Ulcer                                |             2                                                            |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Mucosa, Hyperplasia, Squamous        |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 104                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 6| 7| 1| 5| 7| 1| 6| 6| 6| 7| 4| 7| 6| 5| 7| 4| 7| 7| 4| 7| 4| 6| 4| 1|             
                             DAY ON TEST   | 8| 0| 3| 8| 8| 1| 8| 6| 7| 3| 1| 5| 3| 9| 3| 2| 5| 3| 0| 5| 3| 2| 9| 5| 8|             
                                           | 5| 7| 1| 4| 4| 0| 4| 9| 1| 8| 8| 9| 2| 1| 3| 9| 9| 2| 6| 9| 2| 2| 7| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
     25 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Dentine, Incisor, Dysplasia          |       1                                                        1         |             
      Dentine, Incisor, Necrosis, Focal    |                                                       1                  |             
      Dentine, Incisor, Necrosis,          |                                                                          |             
          Multifocal                       |       1     1  1     1  1           1  1  1  1     1        1            |             
      Incisor, Odontoblast, Degeneration   |                                                                          |             
      Incisor, Ameloblast, Degeneration    |                                                                          |             
      Peridontal Tissue, Molar, Lower,     |                                                                          |             
           Inflammation, Chronic,          |                                                                          |             
          Suppurative                      |             2        4  3  2  3     3     2  3                           |             
      Pulp, Incisor, Inflammation, Chronic,|                                                                          |             
           Necrotizing                     |    4                                                                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Degeneration, Chronic                |       3     2  2     2  3  2  3  2  3  3  2  3  2  3  2  2  3     3  1   |             
      Thrombosis                           |                         X                                         X      |             
      Atrium, Dilatation                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Capsule, Spindle Cell, Hyperplasia   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hyperplasia                          |       2                    2                       2                     |             
      Hypertrophy                          |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                2                                                         |             
      Bilateral, Degeneration, Cystic,     |                                                                          |             
           Focal                           |                                     2                                    |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hyperplasia                          |       1                 3           2        2     2  2     2            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +     +  +     +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +     +  +     +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +   |             
      Pars Distalis, Congestion            |                                                             2            |             
      Pars Distalis, Cyst                  |                                              X           X               |             
      Pars Distalis, Hyperplasia           |                3           3     2  3                    2               |             
      Pars Distalis, Vacuolization         |                                                                          |             
          Cytoplasmic, Focal               |                                                                          |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 105                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 6| 7| 1| 5| 7| 1| 6| 6| 6| 7| 4| 7| 6| 5| 7| 4| 7| 7| 4| 7| 4| 6| 4| 1|             
                             DAY ON TEST   | 8| 0| 3| 8| 8| 1| 8| 6| 7| 3| 1| 5| 3| 9| 3| 2| 5| 3| 0| 5| 3| 2| 9| 5| 8|             
                                           | 5| 7| 1| 4| 4| 0| 4| 9| 1| 8| 8| 9| 2| 1| 3| 9| 9| 2| 6| 9| 2| 2| 7| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
     25 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hyperplasia, Glandular               |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |    2  3     2  2     2  2     2     2        2        1     1     2  2   |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Dilatation                           |                                                                          |             
      Inflammation, Chronic Active         |       2                 3  2        2        2        3     2            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Interstitial Cell, Hyperplasia       |             2              2     2        2     2     2  2     2  2  2   |             
      Seminiferous Tubule, Atrophy         |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Femoral, Atrophy                     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Angiectasis                          |                                                                          |             
      Congestion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Angiectasis                          |                                     4                                    |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Depletion Lymphoid                   |                                                                          |             
      Fibrosis                             |       3                                      2                           |             
      Hematopoietic Cell Proliferation     |                                                    3                     |             
      Red Pulp, Atrophy                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +     +  +     +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Depletion Lymphoid                   |       3     3  3              4     3  3  3  3     3  4     3            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hyperplasia, Cystic                  |    3  1     3  2     2  3  2  2  2  3  2  2  2  1  2  4  2  2  2  3  1   |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Cyst Epithelial Inclusion            |                                        X                          X      |             
      Hyperkeratosis                       |                                                                          |             
      Ulcer                                |                                        3                                 |             
      Sebaceous Gland, Cyst                |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 106                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 6| 7| 1| 5| 7| 1| 6| 6| 6| 7| 4| 7| 6| 5| 7| 4| 7| 7| 4| 7| 4| 6| 4| 1|             
                             DAY ON TEST   | 8| 0| 3| 8| 8| 1| 8| 6| 7| 3| 1| 5| 3| 9| 3| 2| 5| 3| 0| 5| 3| 2| 9| 5| 8|             
                                           | 5| 7| 1| 4| 4| 0| 4| 9| 1| 8| 8| 9| 2| 1| 3| 9| 9| 2| 6| 9| 2| 2| 7| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
     25 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
           Chronic Active                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epiphysis, Tibia, Cyst               |                                                                          |             
      Epiphysis, Tibia, Cyst, Multifocal   |                                                                          |             
      Humerus, Fibrous Osteodystrophy      |                               3                             3            |             
      Humerus, Osteoporosis                |                                                                          |             
      Humerus, Osteosclerosis              |                                                                          |             
      Humerus, Joint, Cartilage, Necrosis, |                                                                          |             
           Focal                           |                                                                          |             
      Humerus, Epiphysis, Cyst             |                                                                          |             
      Joint, Cartilage, Tibia, Degeneration|             1                                                            |             
      Mandible, Fibrous Osteodystrophy     |                               3                                          |             
      Maxilla, Fibrous Osteodystrophy      |                               3                             3            |             
      Thoracic, Vertebra, Fibrous          |                                                                          |             
          Osteodystrophy                   |                               2                             1            |             
      Tibia, Fibrous Osteodystrophy        |                               3                             3            |             
      Tibia, Osteoporosis                  |                                                                          |             
      Tibia, Osteosclerosis                |                                                                          |             
      Tibia, Thrombosis, Chronic, Focal    |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Compression                          |                            X                                             |             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Pleura, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Inflammation, Chronic Active         |                                  2                                       |             
      Mucosa, Inflammation, Acute          |                                                                          |             
      Mucosa, Inflammation, Chronic Active |       1                                2                          3      |             
      Sinus, Foreign Body                  |       1                                2                          3      |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                 +                        |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                       +     +            |             
      Cornea, Hyperplasia, Squamous        |                                                       2                  |             
      Cornea, Inflammation, Chronic Active |                                                                          |             
      Lens, Cataract                       |                                                       2     3            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 107                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 6| 7| 1| 5| 7| 1| 6| 6| 6| 7| 4| 7| 6| 5| 7| 4| 7| 7| 4| 7| 4| 6| 4| 1|             
                             DAY ON TEST   | 8| 0| 3| 8| 8| 1| 8| 6| 7| 3| 1| 5| 3| 9| 3| 2| 5| 3| 0| 5| 3| 2| 9| 5| 8|             
                                           | 5| 7| 1| 4| 4| 0| 4| 9| 1| 8| 8| 9| 2| 1| 3| 9| 9| 2| 6| 9| 2| 2| 7| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
     25 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Retina, Atrophy                      |                                                             4            |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                       +                  |             
      Cyst, Multiple                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Nephropathy, Chronic                 |    2  4     3  2     3  3  2  4  2  3  3  3  3  2  4  4  2  4  2  3  2   |             
      Cortex, Cyst                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 108                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 4| 4| 7| 7| 4| 4| 1| 6| 7| 7| 1| 6| 7| 6| 7| 7| 7| 6|              |            |
                             DAY ON TEST   | 6| 3| 6| 2| 1| 2| 6| 5| 8| 2| 3| 3| 8| 7| 3| 9| 2| 2| 3| 3|              |            |
                                           | 0| 2| 0| 4| 7| 9| 0| 9| 5| 3| 3| 3| 4| 3| 3| 9| 7| 9| 0| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
     25 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +               |  60        |
      Ulcer                                |                                                                          |      1  3.0|
      Serosa, Inflammation, Chronic Active |                                                          3               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +               |  60        |
      Inflammation, Chronic Active,        |                                                                          |            |
          Granulomatous                    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +               |  60        |
      Basophilic Focus                     |    X                             X        X        X  X                  |     23     |
      Clear Cell Focus                     |    X        X  X           X  X  X                 X  X                  |     19     |
      Eosinophilic Focus                   |                                                                          |      3     |
      Hepatodiaphragmatic Nodule           |                            X                                             |      5     |
      Hyperplasia                          |                                                                          |      3  2.7|
      Inflammation, Chronic Active         | 1     1           2  2                                2                  |     11  1.6|
      Mixed Cell Focus                     |                X                                      X                  |      3     |
      Vacuolization Cytoplasmic            | 2     2     4     2  2     2           3  2  2  2  2     3               |     25  2.5|
      Bile Duct, Hyperplasia               | 2  2  2  3  3  3  2  2     2     2     3  2     3        4               |     48  2.5|
      Hepatocyte, Cytomegaly, Focal        |                               2                                          |      1  2.0|
      Hepatocyte, Degeneration, Cystic     |                               2              2                           |      8  2.0|
      Subserosa, Congestion                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                  +        +                              |   9        |
      Fat, Inflammation, Chronic Active    |                                  3        3                              |      7  2.9|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +               |  59        |
      Acinus, Atrophy                      |             1     2        2     2        1     2     3  2               |     18  1.8|
      Artery, Inflammation, Chronic Active |                                                       3                  |      5  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +     +  +  +     +  +  M  +  +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +               |  60        |
      Acanthosis                           |                            3                                             |      3  3.0|
      Ulcer                                |             3                          2     3  2                        |      8  2.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +     +  +  +     +  +  +  +  +  +  +               |  60        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Necrosis                             |                                        2                                 |      3  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 109                                                               
NTP Experiment-Test: 05131-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 04/29/97  
Route: DOSED WATER                                                                                                Time: 18:55:37  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 4| 4| 7| 7| 4| 4| 1| 6| 7| 7| 1| 6| 7| 6| 7| 7| 7| 6|              |            |
                             DAY ON TEST   | 6| 3| 6| 2| 1| 2| 6| 5| 8| 2| 3| 3| 8| 7| 3| 9| 2| 2| 3| 3|              |            |
                                           | 0| 2| 0| 4| 7| 9| 0| 9| 5| 3| 3| 3| 4| 3| 3| 9| 7| 9| 0| 4|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
     25 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Pigmentation, Hemosiderin            |                                                                          |      3  2.0|
      Ulcer                                |             2                                2                           |      3  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                               +                                          |   2        |
      Mucosa, Hyperplasia, Squamous        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  70        |
      Dentine, Incisor, Dysplasia          |             2  1                       1                                 |      7  1.1|
      Dentine, Incisor, Necrosis, F