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TR 395 Rat Pathology Tables

NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97
Route: GAVAGE                                                                                                     Time: 09:45:07




       Facility:  TSI Mason Research

       Chemical CAS #:  57-66-9

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 2| 9| 1| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 9| 9| 3| 3| 2| 5| 3|             
                                           | 5| 5| 2| 2| 0| 5| 6| 5| 4| 5| 5| 5| 5| 5| 5| 5| 6| 2| 3| 5| 5| 6| 9| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X  X     X        X        X        X                           |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                          X               |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                         +     +        +      |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                          X               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                                      X   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X  X              X        X                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma, Metastatic                |                                                                      X   |             
      Leukemia Mononuclear                 |          X  X              X        X                                    |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Leukemia Mononuclear                 |          X  X              X                                             |             
      Pheochromocytoma Benign              |                            X                                             |             
      Bilateral, Pheochromocytoma Benign   |                   X                                                      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  M  +  M  +  M  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |                X     X     X  X  X     X     X        X     X     X     X|             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 2| 9| 1| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 9| 9| 3| 3| 2| 5| 3|             
                                           | 5| 5| 2| 2| 0| 5| 6| 5| 4| 5| 5| 5| 5| 5| 5| 5| 6| 2| 3| 5| 5| 6| 9| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                            X                       X        X     X      |             
      C-Cell, Carcinoma                    |                                  X                                   X   |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  M  +  +  M  M  +  M  +  +  +  M  +  +  M  +  +  +  +  +  M|             
      Adenoma                              |                                                                X         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Benign          |                                                                          |             
      Leukemia Mononuclear                 |          X  X                                                            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Deciduoma NOS                        |                                                                          |             
      Leukemia Mononuclear                 |             X                                                            |             
      Polyp Stromal                        |                      X                                                   |             
      Sarcoma Stromal                      |                                                                          |             
      Bilateral, Polyp Stromal             |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +           +  +  +           +  +  +  +  +  +  +        +            |             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Lumbar, Leukemia Mononuclear         |                                                                          |             
      Mandibular, Carcinoma, Metastatic,   |                                                                          |             
           Thyroid Gland                   |                                                                      X   |             
      Mandibular, Leukemia Mononuclear     |             X                       X                                    |             
      Mediastinal, Leukemia Mononuclear    |          X  X              X        X                                    |             
      Pancreatic, Leukemia Mononuclear     |          X                          X                                    |             
      Renal, Leukemia Mononuclear          |          X                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                       X                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X  X     X        X        X        X                           |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 2| 9| 1| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 9| 9| 3| 3| 2| 5| 3|             
                                           | 5| 5| 2| 2| 0| 5| 6| 5| 4| 5| 5| 5| 5| 5| 5| 5| 6| 2| 3| 5| 5| 6| 9| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Adenocarcinoma                       |                                                                          |             
      Fibroadenoma                         |       X        X                    X     X           X                 X|             
      Fibroadenoma, Multiple               | X                       X        X     X        X  X                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Neurofibroma                         |                                                                          |             
      Sarcoma                              |                               X                                          |             
      Squamous Cell Carcinoma              |                                                                X         |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
      Cerebrum, Oligodendroglioma Malignant|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Carcinoma, Metastatic, Thyroid Gland |                                  X                                   X   |             
      Leukemia Mononuclear                 |          X  X              X        X        X                           |             
      Sarcoma, Metastatic, Uncertain       |                                                                          |             
          Primary Site                     |                                                          X               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma, Metastatic, Thyroid Gland |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |             +                                         +                  |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                 +                       +                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                               +           +                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X  X              X        X                                    |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X  X     X        X        X        X                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 6| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 3|            |
                             DAY ON TEST   | 3| 3| 7| 5| 3| 3| 3| 0| 6| 4| 3| 6| 7| 5| 7| 3| 3| 2| 2| 2| 3| 3| 4| 2| 5|            |
                                           | 5| 6| 5| 2| 6| 5| 5| 4| 3| 4| 5| 3| 7| 2| 9| 5| 6| 0| 0| 9| 5| 5| 9| 2| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X                    X              X     X  X        X  X        X      |         15 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +                       +                        |   6        |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                      X              X     X  X        X  X               |         10 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |                                              X                           |          1 |
      Carcinoma, Metastatic                |                                                                          |          1 |
      Leukemia Mononuclear                 |                                     X        X           X               |          7 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  48        |
      Leukemia Mononuclear                 |                                     X        X           X               |          6 |
      Pheochromocytoma Benign              |                                                                          |          1 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   5                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 6| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 3|            |
                             DAY ON TEST   | 3| 3| 7| 5| 3| 3| 3| 0| 6| 4| 3| 6| 7| 5| 7| 3| 3| 2| 2| 2| 3| 3| 4| 2| 5|            |
                                           | 5| 6| 5| 2| 6| 5| 5| 4| 3| 4| 5| 3| 7| 2| 9| 5| 6| 0| 0| 9| 5| 5| 9| 2| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  M  +  M  +  +  +  +  M|  38        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
      Pars Distalis, Adenoma               |       X  X     X     X  X  X           X        X  X                     |         20 |
      Pars Distalis, Adenoma, Multiple     |                                                                X     X   |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Adenoma                      |       X  X           X                          X  X                     |          9 |
      C-Cell, Carcinoma                    |                                                             X            |          3 |
      Follicular Cell, Adenoma             |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  M  +  M  M|  36        |
      Adenoma                              |                                  X                                X      |          3 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granulosa Cell Tumor Benign          |                   X  X                                                   |          2 |
      Leukemia Mononuclear                 |                                     X     X              X               |          5 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Deciduoma NOS                        |                                                                         X|          1 |
      Leukemia Mononuclear                 |                                     X                                    |          2 |
      Polyp Stromal                        |             X                       X        X     X              X      |          6 |
      Sarcoma Stromal                      |                            X                                             |          1 |
      Bilateral, Polyp Stromal             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +           +              +  +  +        +  +              +     +   |  23        |
      Leukemia Mononuclear                 | X                                   X                                    |          3 |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Axillary, Leukemia Mononuclear       |                      X              X                                    |          2 |
      Lumbar, Leukemia Mononuclear         |                                     X                                    |          1 |
      Mandibular, Carcinoma, Metastatic,   |                                                                          |            |
           Thyroid Gland                   |                                                                          |          1 |
      Mandibular, Leukemia Mononuclear     |                      X              X     X           X  X               |          7 |
      Mediastinal, Leukemia Mononuclear    |                      X              X     X           X  X               |          9 |
      Pancreatic, Leukemia Mononuclear     |                                     X                                    |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   6                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 6| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 3|            |
                             DAY ON TEST   | 3| 3| 7| 5| 3| 3| 3| 0| 6| 4| 3| 6| 7| 5| 7| 3| 3| 2| 2| 2| 3| 3| 4| 2| 5|            |
                                           | 5| 6| 5| 2| 6| 5| 5| 4| 3| 4| 5| 3| 7| 2| 9| 5| 6| 0| 0| 9| 5| 5| 9| 2| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Renal, Leukemia Mononuclear          |                                     X                                    |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                      X              X     X           X  X               |          7 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X                    X              X     X  X        X  X        X      |         15 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                      X              X     X           X                  |          5 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  47        |
      Adenocarcinoma                       |       X  X     X                                                         |          3 |
      Fibroadenoma                         |    X  X     X        X        X        X                       X     X   |         14 |
      Fibroadenoma, Multiple               |          X     X  X                                X                     |         10 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Neurofibroma                         |                                           X                              |          1 |
      Sarcoma                              |                         X                                                |          2 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                X         |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                           X                              |          2 |
      Cerebrum, Oligodendroglioma Malignant|             X                                                            |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                X              X                                          |          2 |
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |          2 |
      Leukemia Mononuclear                 | X                    X              X     X  X        X  X               |         12 |
      Sarcoma, Metastatic, Uncertain       |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   7                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 6| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 3|            |
                             DAY ON TEST   | 3| 3| 7| 5| 3| 3| 3| 0| 6| 4| 3| 6| 7| 5| 7| 3| 3| 2| 2| 2| 3| 3| 4| 2| 5|            |
                                           | 5| 6| 5| 2| 6| 5| 5| 4| 3| 4| 5| 3| 7| 2| 9| 5| 6| 0| 0| 9| 5| 5| 9| 2| 4|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                            +                          +  +              +|   6        |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +              +     +  +                 +  +  +           +|  11        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                               +     +                 +  +               |   6        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                      X              X     X              X               |          8 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X                    X              X     X  X        X  X        X      |         15 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   8                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 2| 2| 0| 3| 3| 3| 3| 3| 2| 3| 3| 0| 5| 3| 3| 3| 3| 3|             
                                           | 4| 4| 4| 4| 3| 4| 4| 2| 2| 8| 4| 4| 4| 3| 7| 9| 4| 4| 3| 1| 4| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    .1 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     LF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |             +                             +           +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +                             +           +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |             +                             +           +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |             +                             +           +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small                         |             +              +              +           +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |             +                             +           +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |             +                             +           +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |             +              +              +           +  +               |             
                                            __________________________________________________________________________|             
   Liver                                   |    +        +  +  +  +     +  +        +  +  +     +  +  +        +     +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |    X              X        X           X     X     X              X     X|             
      Neoplastic Nodule                    |    X                                                                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                            +         |             
                                            __________________________________________________________________________|             
   Pancreas                                |             +              +           +  +           +  +               |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +           +                             +           +  +               |             
                                            __________________________________________________________________________|             
   Stomach                                 |             +                             +           +  +               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |             +                             +           +  +               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |             +                             +           +  +               |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |             +                             +           +  +               |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |             +     +        +           +  +           +  +               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |             +     +        +           +  +           +  +               |             
      Leukemia Mononuclear                 |                   X        X           X                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |             +     +        +           +  +           +  +               |             
      Leukemia Mononuclear                 |                   X        X           X                                 |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |             +              +              +           +  +               |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +  +  +  +  +  +  +  +     +  M     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X        X           X                                 |             
      Pars Distalis, Adenoma               | X  X              X  X  X  X  X  X  X           X     X        X  X  X  X|             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                   X                                                      |             
      C-Cell, Carcinoma                    |                                              X                           |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 2| 2| 0| 3| 3| 3| 3| 3| 2| 3| 3| 0| 5| 3| 3| 3| 3| 3|             
                                           | 4| 4| 4| 4| 3| 4| 4| 2| 2| 8| 4| 4| 4| 3| 7| 9| 4| 4| 3| 1| 4| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    .1 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     LF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |             +  +                          M     +     +  M              +|             
      Adenoma                              |             X  X                                X                       X|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |             +        +                    +           +  +        +      |             
      Granulosa Cell Tumor Benign          |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |             +              +     +        +           +  +           +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Stromal                        |             X              X     X                    X  X           X  X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +                             +           +  +               |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +  +  +  +  +  +  +        +  +           +  +     +         |             
      Axillary, Leukemia Mononuclear       |                   X                                                      |             
      Inguinal, Leukemia Mononuclear       |                            X                                             |             
      Lumbar, Leukemia Mononuclear         |                   X        X           X                                 |             
      Mandibular, Leukemia Mononuclear     |                            X                                             |             
      Mediastinal, Leukemia Mononuclear    |                   X        X           X                                 |             
      Pancreatic, Leukemia Mononuclear     |                            X           X                                 |             
      Renal, Leukemia Mononuclear          |                            X           X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |             +  +     +  +  +  +        +  +           +  +     +         |             
      Leukemia Mononuclear                 |                            X           X                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  |             +  +  +        +           +  +        +  +  +     +        +|             
      Leukemia Mononuclear                 |                   X        X           X           X                    X|             
                                            __________________________________________________________________________|             
   Thymus                                  |             +                          +  +           +  +               |             
      Leukemia Mononuclear                 |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |             +        +  +  +  +     +     +           +  +  +           +|             
      Adenocarcinoma                       |                                                                          |             
      Fibroadenoma                         |             X           X  X                             X  X           X|             
      Fibroadenoma, Multiple               |                      X        X           X                              |             
                                            __________________________________________________________________________|             
   Skin                                    |             +                       +     +           +  +               |             
      Basal Cell Carcinoma                 |                                                                          |             
      Sarcoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |             +                             +           +  +               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 2| 2| 0| 3| 3| 3| 3| 3| 2| 3| 3| 0| 5| 3| 3| 3| 3| 3|             
                                           | 4| 4| 4| 4| 3| 4| 4| 2| 2| 8| 4| 4| 4| 3| 7| 9| 4| 4| 3| 1| 4| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    .1 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     LF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |             +                             +           +  +               |             
      Astrocytoma Benign                   |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +  +  +     +  +                    +     +  +  +  +           +   |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Leukemia Mononuclear                 |                   X                                X                     |             
                                            __________________________________________________________________________|             
   Nose                                    |             +                             +           +  +               |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                            +                                      +      |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                       +  +        +                    +     +     +|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                        +                                 |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X        X                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |             +                             M           +  +               |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |    X              X        X           X     X     X              X     X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 6| 0| 7| 7| 6| 5| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 7| 3| 3| 9| 9| 3| 3| 9| 9| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|            |
                                           | 2| 4| 4| 9| 7| 4| 4| 1| 2| 5| 4| 4| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    .1 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     LF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +           +           +  +                                            +|   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +           +           +  +                                            +|   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +           +           +  +                                            +|   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +           +           +  M                                            +|   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +           +           +  +                                         +  +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +           +           +  +                                            +|   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +           +           +  +                                         +  +|  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +           +           +  +                                         +  +|  11        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +     +        +  +  +           +  +     +  +     +  +  +        +|  30        |
      Histiocytic Sarcoma                  |                                                                X         |          1 |
      Leukemia Mononuclear                 | X           X        X                          X  X     X  X           X|         16 |
      Neoplastic Nodule                    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +           +        +  +  +              +                       +     +|  14        |
      Leukemia Mononuclear                 | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +           +           +  +                                            +|  10        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +           +           +  +                                            +|   9        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +           +           +  +                                            +|   9        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +           +           +  +                                            +|   9        |
      Leukemia Mononuclear                 | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +           +           +  +                                            +|   9        |
      Leukemia Mononuclear                 | X           X                                                           X|          3 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +           +           +  +                          +                 +|  13        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +           +           +  +                          +                 +|  13        |
      Leukemia Mononuclear                 | X           X                                                            |          5 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +           +           +  +                          +                 +|  13        |
      Leukemia Mononuclear                 | X           X                                                            |          5 |
      Pheochromocytoma Benign              |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +           +           +  +                                      +     +|  11        |
      Adenoma                              |                                                                   X      |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  M  +  +  +     +  +  +  +  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X                                                  X                     |          5 |
      Pars Distalis, Adenoma               |    X  X           X     X        X                    X     X     X  X  X|         25 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  12                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 6| 0| 7| 7| 6| 5| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 7| 3| 3| 9| 9| 3| 3| 9| 9| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|            |
                                           | 2| 4| 4| 9| 7| 4| 4| 1| 2| 5| 4| 4| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    .1 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     LF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Adenoma, Multiple     |                                                                X         |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Adenoma                      |                                           X                 X            |          3 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
      Follicular Cell, Adenoma             |                                  X                                       |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +        +  M        +  M  +     +        +        +        +  +     +  +|  16        |
      Adenoma                              |                                  X                             X        X|          7 |
      Carcinoma                            |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +           +  +        +  +     +           +                 +     +  +|  16        |
      Granulosa Cell Tumor Benign          |                X                                                         |          1 |
      Histiocytic Sarcoma                  |                                                                X         |          1 |
      Leukemia Mononuclear                 | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +           +        +  +  +           +              +                 +|  16        |
      Leukemia Mononuclear                 | X                                                                        |          1 |
      Polyp Stromal                        |                      X                 X              X                  |         10 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | M           +           +  +                                            +|   8        |
      Leukemia Mononuclear                 |             X                                                            |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +           +        +  +  +              +        +                 +  +|  21        |
      Axillary, Leukemia Mononuclear       | X                                                  X                     |          3 |
      Inguinal, Leukemia Mononuclear       |                                                                          |          1 |
      Lumbar, Leukemia Mononuclear         |                                                    X                     |          4 |
      Mandibular, Leukemia Mononuclear     | X           X                                      X                     |          4 |
      Mediastinal, Leukemia Mononuclear    | X           X        X                             X                     |          7 |
      Pancreatic, Leukemia Mononuclear     |                      X                             X                     |          4 |
      Renal, Leukemia Mononuclear          |                      X                             X                     |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +           +        +  +  +              +        +                 +  +|  20        |
      Leukemia Mononuclear                 | X           X        X                             X                    X|          7 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +           +        +  +  +           +        +  +  +  +  +           +|  23        |
      Leukemia Mononuclear                 | X           X        X                 X        X  X     X  X           X|         14 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +           +           +  +                                            +|  10        |
      Leukemia Mononuclear                 | X           X                                                           X|          4 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  13                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 6| 0| 7| 7| 6| 5| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 7| 3| 3| 9| 9| 3| 3| 9| 9| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|            |
                                           | 2| 4| 4| 9| 7| 4| 4| 1| 2| 5| 4| 4| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|     A      |
    .1 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     LF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +        +  +  +     +  +     +  +     +  +        +     +  +|  28        |
      Adenocarcinoma                       |                                                                      X   |          1 |
      Fibroadenoma                         | X  X     X           X  X        X  X     X  X        X                 X|         17 |
      Fibroadenoma, Multiple               |       X                                                        X     X   |          6 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +        +  +        +  +                                            +|  12        |
      Basal Cell Carcinoma                 |                X                                                         |          1 |
      Sarcoma                              |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | M           +           +  +                                            +|   8        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +           +           +  +              +                             +|  10        |
      Astrocytoma Benign                   |                                           X                              |          1 |
      Leukemia Mononuclear                 | X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +     +     +     +  +  +     +  +  +     +  +  +  +              +|  26        |
      Alveolar/Bronchiolar Adenoma         |       X                                   X                              |          2 |
      Leukemia Mononuclear                 | X           X                                                           X|          5 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +           +           +  +                                            +|   9        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                      +                    +                              |   4        |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                 +  +                 +        +                 +   |  13        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +                 +  +                          +                     |   5        |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                    +                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X           X        X                             X        X            |          7 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +           +           +  +                                            +|   8        |
      Leukemia Mononuclear                 | X                                                                        |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                                                                X         |          1 |
      Leukemia Mononuclear                 | X           X        X                 X        X  X     X  X           X|         17 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  14                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 1| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 6| 4| 2| 7| 7| 6| 2| 2|             
                             DAY ON TEST   | 3| 9| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 7| 5| 2| 3| 3| 2| 9| 1| 3| 3| 9| 8| 6|             
                                           | 3| 5| 7| 3| 5| 4| 4| 3| 2| 9| 4| 4| 7| 7| 6| 4| 4| 4| 5| 6| 4| 4| 8| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .4 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                X  X  X        X     X        X        X     X     X      |             
      Lymphoma Malignant Histiocytic       |                                  X                                       |             
      Neoplastic Nodule                    |                                                 X                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +     +                                                         |             
      Histiocytic Sarcoma                  |                                                                          |             
      Sarcoma Stromal, Metastatic          |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                                              X                           |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                       +                  |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                                              X        X                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                                              X        X                  |             
      Pheochromocytoma Benign              |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 1| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 6| 4| 2| 7| 7| 6| 2| 2|             
                             DAY ON TEST   | 3| 9| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 7| 5| 2| 3| 3| 2| 9| 1| 3| 3| 9| 8| 6|             
                                           | 3| 5| 7| 3| 5| 4| 4| 3| 2| 9| 4| 4| 7| 7| 6| 4| 4| 4| 5| 6| 4| 4| 8| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .4 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                      X                                                   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  M  +  +  M  M  M  +  +  +  +  +  +  M  +  +  +  M  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
      Pars Distalis, Adenoma               | X     X        X  X     X  X           X     X                    X      |             
      Pars Distalis, Adenoma, Multiple     |                      X                                                   |             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
      Pars Intermedia, Adenoma             |                                              X                           |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, C-Cell, Carcinoma         |                         X                                                |             
      C-Cell, Adenoma                      |                                                                          |             
      C-Cell, Carcinoma                    |                                                                   X      |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Arrhenoblastoma Benign               |                                                                          |             
      Granulosa Cell Tumor Benign          |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Adenoma                              |                                                                          |             
      Leiomyosarcoma                       |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Polyp Stromal                        |                                  X           X     X  X                  |             
      Sarcoma Stromal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +              +  +  +        +  +           +  +           +  +         |             
      Leukemia Mononuclear                 |                                              X                           |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Leukemia Mononuclear       |                                              X                           |             
      Mandibular, Carcinoma, Metastatic,   |                                                                          |             
           Thyroid Gland                   |                         X                                                |             
      Mandibular, Leukemia Mononuclear     |                               X              X                           |             
      Mandibular, Lymphoma Malignant       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 1| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 6| 4| 2| 7| 7| 6| 2| 2|             
                             DAY ON TEST   | 3| 9| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 7| 5| 2| 3| 3| 2| 9| 1| 3| 3| 9| 8| 6|             
                                           | 3| 5| 7| 3| 5| 4| 4| 3| 2| 9| 4| 4| 7| 7| 6| 4| 4| 4| 5| 6| 4| 4| 8| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .4 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Undifferentiated Cell Type       |    X                                                                     |             
      Mediastinal, Leukemia Mononuclear    |                                              X        X           X      |             
      Pancreatic, Leukemia Mononuclear     |                               X                                          |             
      Renal, Leukemia Mononuclear          |                                              X                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X              X                           |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X  X  X        X     X        X        X     X  X  X      |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                          X                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  M  +  M  M|             
      Fibroadenoma                         |       X                                X           X        X            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |    X                                                                     |             
      Carcinoma, Metastatic, Thyroid Gland |                         X                                                |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                X                             X        X           X      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                         +|             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                               +              +      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                                               +              +      |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X        X        X                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 1| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 6| 4| 2| 7| 7| 6| 2| 2|             
                             DAY ON TEST   | 3| 9| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 7| 5| 2| 3| 3| 2| 9| 1| 3| 3| 9| 8| 6|             
                                           | 3| 5| 7| 3| 5| 4| 4| 3| 2| 9| 4| 4| 7| 7| 6| 4| 4| 4| 5| 6| 4| 4| 8| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .4 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  M  +  +  +  +  A  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                X  X  X        X     X        X        X     X  X  X      |             
      Lymphoma Malignant Histiocytic       |                                  X                                       |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 0| 7| 6| 6| 5| 5| 7| 7| 5| 2| 2| 7| 7| 7| 6| 6| 7| 7| 7| 6| 2|            |
                             DAY ON TEST   | 2| 0| 5| 9| 9| 3| 4| 0| 9| 1| 3| 3| 6| 7| 6| 3| 3| 3| 7| 0| 3| 3| 3| 5| 0|            |
                                           | 1| 5| 2| 2| 4| 2| 9| 5| 2| 2| 4| 4| 1| 0| 6| 4| 4| 4| 0| 4| 4| 4| 4| 8| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    .4 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  A  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +|  44        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                                                       X                  |          1 |
      Leukemia Mononuclear                 | X  X     X        X                 X                          X     X   |         16 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Neoplastic Nodule                    | X                                                                        |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +        +                                      +                 +|   6        |
      Histiocytic Sarcoma                  |                                                       X                  |          1 |
      Sarcoma Stromal, Metastatic          |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                                                       X                  |          1 |
      Leukemia Mononuclear                 |                                                                      X   |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Leukemia Mononuclear                 |          X                                                           X   |          2 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Histiocytic Sarcoma                  |                                                       X                  |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Histiocytic Sarcoma                  |                                                       X                  |          1 |
      Leukemia Mononuclear                 |    X                                                                     |          2 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X     X        X                 X                                X   |          6 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |                   X                                                      |          1 |
      Histiocytic Sarcoma                  |                                                       X                  |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  19                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 0| 7| 6| 6| 5| 5| 7| 7| 5| 2| 2| 7| 7| 7| 6| 6| 7| 7| 7| 6| 2|            |
                             DAY ON TEST   | 2| 0| 5| 9| 9| 3| 4| 0| 9| 1| 3| 3| 6| 7| 6| 3| 3| 3| 7| 0| 3| 3| 3| 5| 0|            |
                                           | 1| 5| 2| 2| 4| 2| 9| 5| 2| 2| 4| 4| 1| 0| 6| 4| 4| 4| 0| 4| 4| 4| 4| 8| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    .4 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |          X        X                                                  X   |          5 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  45        |
      Histiocytic Sarcoma                  |                                                       X                  |          1 |
      Leukemia Mononuclear                 |          X                                                           X   |          4 |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |    X                                                                     |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  M  M  +  +  M  +  M  +  +  +  +  +  +  +  M  M  M|  34        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                   X                                                      |          2 |
      Pars Distalis, Adenoma               |    X           X                             X  X     X           X      |         15 |
      Pars Distalis, Adenoma, Multiple     |                                                                          |          1 |
      Pars Distalis, Leukemia Mononuclear  |                                                                      X   |          1 |
      Pars Intermedia, Adenoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  47        |
      Bilateral, C-Cell, Carcinoma         |                                                                          |          1 |
      C-Cell, Adenoma                      |                                              X                           |          1 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
      Follicular Cell, Adenoma             |                                                             X            |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  M  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  45        |
      Adenoma                              |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Arrhenoblastoma Benign               |                                              X                           |          1 |
      Granulosa Cell Tumor Benign          |          X                                                               |          1 |
      Histiocytic Sarcoma                  |                                                       X                  |          1 |
      Leukemia Mononuclear                 |    X              X                                                  X   |          4 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |                                                             X            |          1 |
      Leiomyosarcoma                       | X                                                                        |          1 |
      Leukemia Mononuclear                 |                   X                                                  X   |          2 |
      Polyp Stromal                        |                         X                    X        X     X  X         |          9 |
      Sarcoma Stromal                      |       X              X                                                   |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  20                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 0| 7| 6| 6| 5| 5| 7| 7| 5| 2| 2| 7| 7| 7| 6| 6| 7| 7| 7| 6| 2|            |
                             DAY ON TEST   | 2| 0| 5| 9| 9| 3| 4| 0| 9| 1| 3| 3| 6| 7| 6| 3| 3| 3| 7| 0| 3| 3| 3| 5| 0|            |
                                           | 1| 5| 2| 2| 4| 2| 9| 5| 2| 2| 4| 4| 1| 0| 6| 4| 4| 4| 0| 4| 4| 4| 4| 8| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    .4 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                +              +  +           +  +  +        +  +         |  18        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Axillary, Leukemia Mononuclear       |                                                                          |          1 |
      Mandibular, Carcinoma, Metastatic,   |                                                                          |            |
           Thyroid Gland                   |                                                                          |          1 |
      Mandibular, Leukemia Mononuclear     |    X     X        X                 X                                X   |          7 |
      Mandibular, Lymphoma Malignant       |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |    X     X        X                 X                                X   |          8 |
      Pancreatic, Leukemia Mononuclear     |                   X                 X                                    |          3 |
      Renal, Leukemia Mononuclear          |    X                                                                 X   |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X  X     X        X                 X                                X   |          8 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X  X     X        X                 X                          X     X   |         17 |
      Sarcoma                              |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Leukemia Mononuclear                 | X  X              X                 X                                X   |          7 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  M  +  M  +  +  +  M  +  +  M  M  +  +  +  +  M  M  +  +  +  +|  36        |
      Fibroadenoma                         |                            X                                             |          5 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Histiocytic Sarcoma                  |                                                       X                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                      X   |          2 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  21                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 0| 7| 6| 6| 5| 5| 7| 7| 5| 2| 2| 7| 7| 7| 6| 6| 7| 7| 7| 6| 2|            |
                             DAY ON TEST   | 2| 0| 5| 9| 9| 3| 4| 0| 9| 1| 3| 3| 6| 7| 6| 3| 3| 3| 7| 0| 3| 3| 3| 5| 0|            |
                                           | 1| 5| 2| 2| 4| 2| 9| 5| 2| 2| 4| 4| 1| 0| 6| 4| 4| 4| 0| 4| 4| 4| 4| 8| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|     A      |
    .4 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Carcinoma, Metastatic, Thyroid Gland |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                       X                  |          1 |
      Leukemia Mononuclear                 |    X     X        X                 X                          X     X   |         10 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                     +                                    |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                             +  +                                    |   6        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +                             +  +                 +                  |   7        |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                       +                  |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                      X   |          4 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Leukemia Mononuclear                 |          X        X                                                      |          3 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Histiocytic Sarcoma                  |                                                       X                  |          1 |
      Leukemia Mononuclear                 | X  X     X        X                 X                          X     X   |         17 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  22                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 4| 0| 1| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 4| 0| 9| 3| 3| 3| 3| 9|             
                                           | 7| 0| 7| 0| 7| 8| 7| 7| 7| 7| 8| 8| 7| 0| 6| 8| 8| 0| 8| 3| 8| 8| 8| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                             X            |             
      Neoplastic Nodule                    |                   X                                                      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +     +  +           +     +         |             
      Mesothelioma Benign                  |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Benign                  |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                          +               |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                  X                                       |             
      Leukemia Mononuclear                 |                               X                             X            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                             X            |             
      Pheochromocytoma Malignant           |                         X                                                |             
      Pheochromocytoma Benign              |       X           X                                         X            |             
      Bilateral, Pheochromocytoma Benign   |                                  X           X                    X      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                     X                                    |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  M  M  +  +  +  +  +  +  +  +  M  +  +  +  M  M  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 4| 0| 1| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 4| 0| 9| 3| 3| 3| 3| 9|             
                                           | 7| 0| 7| 0| 7| 8| 7| 7| 7| 7| 8| 8| 7| 0| 6| 8| 8| 0| 8| 3| 8| 8| 8| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               | X     X  X              X              X  X  X        X     X            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      | X                                               X  X           X         |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                              X        X                 X|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X     X  X  X  X  X  X  X  X  X     X  X  X  X     X  X     X  X|             
      Interstitial Cell, Adenoma           |                                                                   X      |             
      Tunic, Mesothelioma Benign           |                                                                          |             
      Tunic, Mesothelioma Malignant        |       X                                                           X      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +              +  +  +  +  +  +  +        +     +        +  +  +  +   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Bronchial, Mediastinal, Fibrosarcoma,|                                                                          |             
           Metastatic, Skin                |             X                                                            |             
      Lumbar, Leukemia Mononuclear         |                                                                          |             
      Mandibular, Leukemia Mononuclear     |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                             X            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 4| 0| 1| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 4| 0| 9| 3| 3| 3| 3| 9|             
                                           | 7| 0| 7| 0| 7| 8| 7| 7| 7| 7| 8| 8| 7| 0| 6| 8| 8| 0| 8| 3| 8| 8| 8| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Epithelial Cell, Thymoma Benign      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  M  M  M  +  M  M  M  +  +  +  +  M  +  +  M  +  M  M  +  +|             
      Fibroadenoma                         |    X                                                  X                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Adenoma                   |                                                                          |             
      Keratoacanthoma                      |                                                 X                        |             
      Leukemia Mononuclear                 |                                                                          |             
      Trichoepithelioma                    |                                                                          |             
      Subcutaneous Tissue, Fibroma         |          X              X                       X           X            |             
      Subcutaneous Tissue, Fibrosarcoma    |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |             +                                                            |             
      Fibrosarcoma, Metastatic, Skin       |             X                                                            |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                    X                     |             
      Fibrosarcoma, Metastatic, Skin       |             X                                                            |             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basosquamous Tumor Benign            |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Fibrosarcoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                          +  +                              |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                        +  +                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosarcoma, Metastatic, Skin       |             X                                                            |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 4| 0| 1| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 4| 0| 9| 3| 3| 3| 3| 9|             
                                           | 7| 0| 7| 0| 7| 8| 7| 7| 7| 7| 8| 8| 7| 0| 6| 8| 8| 0| 8| 3| 8| 8| 8| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                             X            |             
      Mesothelioma Benign                  |                                                                          |             
      Mesothelioma Malignant               |       X                                                           X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 4| 5| 3| 3| 3| 4| 5| 3| 3| 3| 3| 7|            |
                                           | 8| 0| 7| 7| 7| 8| 8| 7| 7| 3| 8| 8| 8| 0| 1| 8| 8| 8| 0| 8| 8| 8| 0| 0| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  M  +  +  A  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +  +  +  +     +  +  +  +  +  A  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X        X                                            X  X   |          6 |
      Neoplastic Nodule                    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +              +  +  +                                             |   9        |
      Mesothelioma Benign                  |                      X                                                   |          1 |
      Mesothelioma Malignant               |                         X  X                                             |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                      X   |          1 |
      Mesothelioma Benign                  |                      X                                                   |          1 |
      Mesothelioma Malignant               |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |                                                                      X   |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X        X                                            X  X   |          4 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |       X                                                                  |          2 |
      Leukemia Mononuclear                 |             X        X                                            X  X   |          6 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |             X        X                                               X   |          5 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  27                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 4| 5| 3| 3| 3| 4| 5| 3| 3| 3| 3| 7|            |
                                           | 8| 0| 7| 7| 7| 8| 8| 7| 7| 3| 8| 8| 8| 0| 1| 8| 8| 8| 0| 8| 8| 8| 0| 0| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pheochromocytoma Benign              | X  X              X     X           X  X           X  X     X  X     X   |         14 |
      Bilateral, Pheochromocytoma Benign   |             X  X                                                         |          5 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |                                              X                           |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                      X   |          1 |
      Pars Distalis, Adenoma               | X  X  X                                      X  X              X         |         15 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      C-Cell, Adenoma                      |    X  X                                X        X  X                     |          9 |
      C-Cell, Carcinoma                    |                                                 X                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mesothelioma Malignant               |                         X  X                                             |          2 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |                                           X     X           X            |          6 |
      Leukemia Mononuclear                 |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X     X  X  X  X  X  X  X  X  X  X  X        X     X  X  X  X  X|         42 |
      Interstitial Cell, Adenoma           |                                                 X  X                     |          3 |
      Tunic, Mesothelioma Benign           |                      X                                                   |          1 |
      Tunic, Mesothelioma Malignant        |                         X  X                                             |          4 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +     +  +  +  +  +  +        +  +  +  +     +  +  +        +  +         |  31        |
      Leukemia Mononuclear                 |             X        X                                                   |          2 |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Axillary, Leukemia Mononuclear       |                                                                      X   |          1 |
      Bronchial, Mediastinal, Fibrosarcoma,|                                                                          |            |
           Metastatic, Skin                |                                                                          |          1 |
      Lumbar, Leukemia Mononuclear         |                                                                      X   |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  28                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 4| 5| 3| 3| 3| 4| 5| 3| 3| 3| 3| 7|            |
                                           | 8| 0| 7| 7| 7| 8| 8| 7| 7| 3| 8| 8| 8| 0| 1| 8| 8| 8| 0| 8| 8| 8| 0| 0| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mandibular, Leukemia Mononuclear     |             X        X                                               X   |          3 |
      Mediastinal, Leukemia Mononuclear    |             X                                                        X   |          2 |
      Pancreatic, Leukemia Mononuclear     |                                                                      X   |          1 |
      Renal, Leukemia Mononuclear          |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X        X                                               X   |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X        X                                            X  X   |          6 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +|  46        |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
      Leukemia Mononuclear                 |             X                                                            |          1 |
      Epithelial Cell, Thymoma Benign      |                                                    X                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  M  M  +  M  M  +  M  +  +  M  M  M  M  M  M  +  M  +  M  +  +  +|  26        |
      Fibroadenoma                         |                X                                                         |          3 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basal Cell Adenoma                   | X                                                                        |          1 |
      Keratoacanthoma                      |                               X                                          |          2 |
      Leukemia Mononuclear                 |                                                                      X   |          1 |
      Trichoepithelioma                    |                                                                      X   |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                         X|          5 |
      Subcutaneous Tissue, Fibrosarcoma    |                                           X                              |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                         +                                                |   2        |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
      Mesothelioma Malignant               |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X                                                            |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                   X     X|          3 |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
      Leukemia Mononuclear                 |             X        X                                            X  X   |          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  29                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 4| 5| 3| 3| 3| 4| 5| 3| 3| 3| 3| 7|            |
                                           | 8| 0| 7| 7| 7| 8| 8| 7| 7| 3| 8| 8| 8| 0| 1| 8| 8| 8| 0| 8| 8| 8| 0| 0| 1|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|     A      |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      Basosquamous Tumor Benign            |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                    +                     |   1        |
      Fibrosarcoma                         |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Eye                                     |                         +                                         +      |   5        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                         +                                         +      |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosarcoma, Metastatic, Skin       |                                                                          |          1 |
      Leukemia Mononuclear                 |             X        X                                            X  X   |          4 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Mesothelioma Malignant               |                         X                                                |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |             X        X                                            X  X   |          6 |
      Mesothelioma Benign                  |                      X                                                   |          1 |
      Mesothelioma Malignant               |                         X  X                                             |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  30                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 2| 6| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 5| 9|             
                                           | 5| 5| 3| 7| 4| 5| 5| 5| 5| 2| 6| 6| 5| 5| 1| 6| 6| 6| 0| 6| 6| 6| 6| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .1 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    LM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                            +           +  +              +              +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +                    +              +              +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                            A              +              +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                            +              +              +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +                    +              +              +              +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |          +                 +              +              +              +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |          +                 +              +              +              +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                            +              +              +              +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |          +                 +              +              +              +|             
      Adenocarcinoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Skin                            |                                           X                              |             
      Hepatocellular Carcinoma             |                X                                                         |             
      Leukemia Mononuclear                 |          X                                X                             X|             
      Neoplastic Nodule                    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                         +               |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                X                                                         |             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                          X               |             
                                            __________________________________________________________________________|             
   Pancreas                                |          +     +  +        +  +  +        +  +     +  +  +        +     +|             
      Mesothelioma Malignant               |                                                          X               |             
                                            __________________________________________________________________________|             
   Pharynx                                 |       +                                                                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |          +     +  +        +  +  +        +     +        +              +|             
                                            __________________________________________________________________________|             
   Stomach                                 |                            +              +              +              +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                            +              +              +              +|             
      Mesothelioma Malignant               |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                            +              +              +              +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                            +              +              +              +|             
      Leukemia Mononuclear                 |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                              X|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                              X|             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              | X                    X           X  X     X  X        X     X  X         |             
      Bilateral, Pheochromocytoma Benign   |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 2| 6| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 5| 9|             
                                           | 5| 5| 3| 7| 4| 5| 5| 5| 5| 2| 6| 6| 5| 5| 1| 6| 6| 6| 0| 6| 6| 6| 6| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .1 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    LM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |          +     +  +        +     +        +  +     +  +  +        +     +|             
      Adenoma                              |                                                       X                  |             
      Carcinoma                            |                                                    X                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                   +        +           +  +              +              +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +           +  +  +  +     +              +     +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |                X  X  X                    X     X  X  X        X     X   |             
      Pars Distalis, Adenoma, Multiple     |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                   +        +           +  +              +              +|             
      C-Cell, Adenoma                      |                   X                    X                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |             +              +  +     +  +  +        +     +              +|             
      Mesothelioma Malignant               |                                                          X               |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +     +  +     +     +     +                       +              +|             
      Adenoma                              |                                  X                                       |             
      Carcinoma                            |                      X                                                   |             
      Bilateral, Adenoma                   |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |                            +              +  +           +              +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |       +  +                 +     +        +  +  +  +  +  +        +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +     +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma| X     X  X  X     X     X     X     X        X  X     X  X  X  X  X  X   |             
      Bilateral, Interstitial Tissue,      |                                                                          |             
          Adenoma                          |                                  X                                       |             
      Interstitial Cell, Adenoma           |                                        X           X                     |             
      Tunic, Mesothelioma Malignant        |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                            +              +              +              +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +  +  +  +        +  +  +     +  +        +     +        +     +|             
      Mediastinal, Fibrous Histiocytoma,   |                                                                          |             
           Metastatic, Skin                |                                           X                              |             
      Mediastinal, Leukemia Mononuclear    |                                                                         X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +  +  +  +           +           +  +        +     +        +     +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mandibular, Leukemia Mononuclear     |                                                                         X|             
      Mediastinal, Hepatocellular          |                                                                          |             
          Carcinoma, Metastatic, Liver     |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 2| 6| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 5| 9|             
                                           | 5| 5| 3| 7| 4| 5| 5| 5| 5| 2| 6| 6| 5| 5| 1| 6| 6| 6| 0| 6| 6| 6| 6| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .1 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    LM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |          +                 +              +  +           +              +|             
      Leukemia Mononuclear                 |          X                                X                             X|             
      Mesothelioma Malignant               |                                                          X               |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +     +  +           +              +              +              +|             
      Leukemia Mononuclear                 |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                            M              M        +     M           +  +|             
      Fibroadenoma                         |                                                    X                 X   |             
                                            __________________________________________________________________________|             
   Skin                                    |       +     +              +     +        +     +        +              +|             
      Basal Cell Adenoma                   |                                  X                                       |             
      Basal Cell Carcinoma                 |                                                                          |             
      Fibrous Histiocytoma                 |                                           X                              |             
      Keratoacanthoma                      |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
      Trichoepithelioma                    |                                  X                                       |             
      Subcutaneous Tissue, Fibroma         |       X                                         X                        |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |             X                                                            |             
      Subcutaneous Tissue, Schwannoma      |                                                                          |             
          Malignant                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                            +              +              +              +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                           +                              |             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Skin                            |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                            +              +              +              +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |             +  +     +     +              +           +  +              +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Skin                            |                                           X                              |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                X                                                         |             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Nose                                    |                            +              +              +              +|             
                                            __________________________________________________________________________|             
   Trachea                                 |             +  +  +  +     +           +  +           +  +              +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 2| 6| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 5| 9|             
                                           | 5| 5| 3| 7| 4| 5| 5| 5| 5| 2| 6| 6| 5| 5| 1| 6| 6| 6| 0| 6| 6| 6| 6| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .1 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    LM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     | +                                                        +               |             
      Fibrosarcoma                         | X                                                                        |             
                                            __________________________________________________________________________|             
   Eye                                     |          +     +                          +              +               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +     +                          +              +               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                              X|             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                +           +              +  +           +              +|             
      Fibrous Histiocytoma, Metastatic,    |                                                                          |             
           Skin                            |                                           X                              |             
      Leukemia Mononuclear                 |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                X                             X|             
      Mesothelioma Malignant               |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 5| 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 8| 6| 3| 3| 3| 9| 9| 3| 3| 3| 3| 7|            |
                                           | 7| 1| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 2| 2| 7| 7| 7| 9| 4| 7| 7| 7| 0| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    .1 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    LM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +     +                 +           +  +  +                          +|  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |          +                 +           +  +                              |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +                 +           +  +                              |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +                 +           +  +                              |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +                 +           +  +                              |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |          +                 +           +  +                              |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          +                 +           +  +                              |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          +                 +           +  +                              |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +                 M           +  +                              |   8        |
      Adenocarcinoma                       |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +        +     +  +  +|  41        |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Skin                            |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Leukemia Mononuclear                 | X           X     X        X              X                             X|          9 |
      Neoplastic Nodule                    | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                               +                       +                  |   4        |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                       X                  |          1 |
      Mesothelioma Malignant               |                               X                                          |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |          +                 +  +        +  +     +     +                  |  20        |
      Mesothelioma Malignant               |                               X                                          |          2 |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +           +     +           +  +                          +   |  16        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |          +                 +  +  +     +  +           +  +               |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +                 +  +  +     +  +           +  +               |  12        |
      Mesothelioma Malignant               |                               X                                          |          1 |
      Squamous Cell Papilloma              |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +                 +     +     +  +           +  +               |  11        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +                 +           +  +                              |   8        |
      Leukemia Mononuclear                 |                            X              X                              |          3 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                   X        X              X           X                 X|          7 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  35                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 5| 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 8| 6| 3| 3| 3| 9| 9| 3| 3| 3| 3| 7|            |
                                           | 7| 1| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 2| 2| 7| 7| 7| 9| 4| 7| 7| 7| 0| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    .1 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    LM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                   X        X              X                              |          5 |
      Pheochromocytoma Malignant           |                                                                      X   |          1 |
      Pheochromocytoma Benign              |    X  X     X                 X  X                    X                 X|         16 |
      Bilateral, Pheochromocytoma Benign   |                                              X                           |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +                 +           +  +     +     +  +               |  19        |
      Adenoma                              |                                                       X                  |          2 |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          +                 M           +  +  +                          +|  11        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +     +  +        +     +           +  +     +  +  +     +     +      |  26        |
      Leukemia Mononuclear                 |                                           X           X                  |          2 |
      Pars Distalis, Adenoma               |    X                 X                    X                              |         12 |
      Pars Distalis, Adenoma, Multiple     |             X                                               X            |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |          +                 +           +  +  +                          +|  12        |
      C-Cell, Adenoma                      |                                              X                           |          3 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +        +     +  +  +  +  +  +  +  +  +  +        +     +     +  +  +   |  26        |
      Mesothelioma Malignant               |                               X                                          |          2 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +        +           +     +           +  +  +                           |  15        |
      Adenoma                              |                      X                                                   |          2 |
      Carcinoma                            |                                              X                           |          2 |
      Bilateral, Adenoma                   |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                |          +                 +           +  +           +                  |  10        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +     +     +     +  +  +  +  +     +  +  +  +  +     +     +     +   |  30        |
      Mesothelioma Malignant               |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|  44        |
      Leukemia Mononuclear                 |                            X              X                              |          2 |
      Bilateral, Interstitial Cell, Adenoma| X  X  X        X  X  X  X     X     X           X  X     X  X  X  X  X  X|         33 |
      Bilateral, Interstitial Tissue,      |                                                                          |            |
          Adenoma                          |                                                                          |          1 |
      Interstitial Cell, Adenoma           |                            X     X     X                                 |          5 |
      Tunic, Mesothelioma Malignant        |                               X                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                               +                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  36                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 5| 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 8| 6| 3| 3| 3| 9| 9| 3| 3| 3| 3| 7|            |
                                           | 7| 1| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 2| 2| 7| 7| 7| 9| 4| 7| 7| 7| 0| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    .1 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    LM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +                 +           +  +                              |   8        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +        +           +     +  +     +  +  +     +     +     +        +  +|  27        |
      Mediastinal, Fibrous Histiocytoma,   |                                                                          |            |
           Metastatic, Skin                |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                            X              X                              |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +        +                 +  +        +  +           +     +        +   |  20        |
      Leukemia Mononuclear                 |                                           X                              |          1 |
      Mandibular, Leukemia Mononuclear     |                                                                          |          1 |
      Mediastinal, Hepatocellular          |                                                                          |            |
          Carcinoma, Metastatic, Liver     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +        +  +     +        +  +  +     +  +  +        +           +     +|  19        |
      Leukemia Mononuclear                 | X           X     X        X              X           X                 X|         10 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |          +           +     +           +  +           +  +               |  14        |
      Leukemia Mononuclear                 |                            X                                             |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          +           +     M           +  +           +     +            |   9        |
      Fibroadenoma                         |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +        +           +  +  +  +  +     +  +              +  +  +         |  20        |
      Basal Cell Adenoma                   |                                                                          |          1 |
      Basal Cell Carcinoma                 |                                                             X            |          1 |
      Fibrous Histiocytoma                 |                                                                          |          1 |
      Keratoacanthoma                      |                                                          X               |          1 |
      Squamous Cell Carcinoma              | X                                                                        |          1 |
      Squamous Cell Papilloma              |                               X                                          |          1 |
      Trichoepithelioma                    |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                         X                                                |          3 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                X         |          1 |
      Subcutaneous Tissue, Sarcoma         |                                                                          |          1 |
      Subcutaneous Tissue, Schwannoma      |                                                                          |            |
          Malignant                        |                                                          X               |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |          +                 +           +  +                              |   8        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Skin                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  37                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 5| 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 8| 6| 3| 3| 3| 9| 9| 3| 3| 3| 3| 7|            |
                                           | 7| 1| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 2| 2| 7| 7| 7| 9| 4| 7| 7| 7| 0| 2|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|     A      |
    .1 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
    LM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +                 +           +  +                              |   8        |
      Leukemia Mononuclear                 |                            X              X                              |          2 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +     +     +  +        +     +     +  +           +                  |  18        |
      Alveolar/Bronchiolar Adenoma         |                X                          X                              |          2 |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Skin                            |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Leukemia Mononuclear                 | X                          X              X           X                  |          5 |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +     +                 +           +  +                              |   9        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +        +     +  +        +           +  +           +                  |  18        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                           +                              |   3        |
      Fibrosarcoma                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                     +  +  +           +                  |   8        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                     +  +              +                  |   7        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                   X        X              X                              |          5 |
      Renal Tubule, Adenoma                |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          +                 +           +  +                              |  10        |
      Fibrous Histiocytoma, Metastatic,    |                                                                          |            |
           Skin                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 | X           X     X        X              X           X                 X|         10 |
      Mesothelioma Malignant               |                               X                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  38                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 0| 9| 8| 3| 3| 2| 1| 5| 3| 2| 6| 0| 9| 3| 3| 3| 0| 0| 3| 1| 0| 0| 9|             
                                           | 0| 0| 8| 5| 8| 0| 0| 7| 1| 7| 0| 3| 6| 0| 1| 5| 5| 0| 6| 3| 0| 3| 4| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .4 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |       X                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leiomyoma                            |                                                                X         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X                 X     X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                         X|             
                                            __________________________________________________________________________|             
   Mesentery                               |    +  +                       +                                +     +   |             
      Mesothelioma Malignant               |       X                                                              X   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |       X                                                              X   |             
      Acinus, Adenoma                      |                                              X                           |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X                       X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                         X|             
      Mesothelioma Malignant, Metastatic   |                                                                          |             
      Schwannoma Malignant                 |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X                 X     X      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X                 X     X      |             
      Pheochromocytoma Benign              |                X                                                         |             
      Bilateral, Pheochromocytoma Benign   |                                  X                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                               X                          X           X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 0| 9| 8| 3| 3| 2| 1| 5| 3| 2| 6| 0| 9| 3| 3| 3| 0| 0| 3| 1| 0| 0| 9|             
                                           | 0| 0| 8| 5| 8| 0| 0| 7| 1| 7| 0| 3| 6| 0| 1| 5| 5| 0| 6| 3| 0| 3| 4| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .4 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Carcinoma                            |                                                                      X   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  M  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X  X                       X  X                                X  X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                              X                           |             
      C-Cell, Adenoma                      | X           X                                                  X     X   |             
      Follicular Cell, Adenoma             |                X                                                         |             
      Follicular Cell, Carcinoma           |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +|             
      Mesothelioma Malignant               |       X                                                                  |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                     X     X  X        X                  |             
      Carcinoma                            |                      X                                                   |             
      Bilateral, Adenoma                   |                X                       X                                 |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |       X                                                                  |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X  X  X  X  X  X     X  X  X  X        X     X  X  X  X     X   |             
      Interstitial Cell, Adenoma           |                                              X     X              X     X|             
      Tunic, Mesothelioma Malignant        |       X                                X                             X   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +           +  +           +              +  +  +        +            |             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mandibular, Leukemia Mononuclear     |                                           X                              |             
      Mediastinal, Leukemia Mononuclear    |                                           X                              |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Undifferentiated Cell Type       |                                                                         X|             
      Pancreatic, Leukemia Mononuclear     |                                           X                              |             
      Renal, Leukemia Mononuclear          |                                           X                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Leukemia Mononuclear                 |                                           X                       X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X                 X     X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 0| 9| 8| 3| 3| 2| 1| 5| 3| 2| 6| 0| 9| 3| 3| 3| 0| 0| 3| 1| 0| 0| 9|             
                                           | 0| 0| 8| 5| 8| 0| 0| 7| 1| 7| 0| 3| 6| 0| 1| 5| 5| 0| 6| 3| 0| 3| 4| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .4 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X                       X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  +  M  M  +  +  M  M  +  +  +  +  M  M  M  +  +  M  +  M  +  M  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |                                                                          |             
      Squamous Cell Papilloma              |                                  X                                       |             
      Subcutaneous Tissue, Fibroma         |                   X              X                                       |             
      Subcutaneous Tissue, Sarcoma         |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |       +                                                        +        +|             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                         X|             
      Mesothelioma Malignant               |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |                                                                          |             
      Granular Cell Tumor Benign           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                X                    X        X                           |             
      Leukemia Mononuclear                 |                                           X                 X     X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                         X|             
      Pleura, Mesothelioma Malignant       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |             +                             +                              |             
                                            __________________________________________________________________________|             
   Eye                                     |                +  +     +  +              +           +           +  +   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +           +                             +                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 0| 9| 8| 3| 3| 2| 1| 5| 3| 2| 6| 0| 9| 3| 3| 3| 0| 0| 3| 1| 0| 0| 9|             
                                           | 0| 0| 8| 5| 8| 0| 0| 7| 1| 7| 0| 3| 6| 0| 1| 5| 5| 0| 6| 3| 0| 3| 4| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .4 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X                 X     X      |             
      Lymphoma Malignant Undifferentiated  |                                                                          |             
          Cell Type                        |                                                                         X|             
      Mesothelioma Malignant               |       X                                X                             X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 6| 6| 3| 5| 7| 6| 5| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 0| 3| 3| 0| 6| 5| 7| 8| 3| 7| 6| 1|            |
                                           | 5| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 0| 0| 6| 5| 7| 0| 2| 2| 0| 5| 0| 2| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    .4 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenocarcinoma                       |                                                                      X   |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  47        |
      Leiomyoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X                       X                                X           X|          7 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   5        |
      Mesothelioma Malignant               |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mesothelioma Malignant               |                                                                          |          2 |
      Acinus, Adenoma                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                            X                                            X|          4 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Mesothelioma Malignant, Metastatic   |    X                                                                     |          1 |
      Schwannoma Malignant                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X                       X                                             |          5 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  43                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 6| 6| 3| 5| 7| 6| 5| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 0| 3| 3| 0| 6| 5| 7| 8| 3| 7| 6| 1|            |
                                           | 5| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 0| 0| 6| 5| 7| 0| 2| 2| 0| 5| 0| 2| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    .4 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |    X                       X                                             |          5 |
      Pheochromocytoma Benign              |                   X           X              X                 X     X   |          6 |
      Bilateral, Pheochromocytoma Benign   |    X                                                                     |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Adenoma                              |                                                                          |          3 |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Adenoma               |       X     X  X  X                 X           X  X        X  X     X  X|         17 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Carcinoma                            |                                                                          |          1 |
      C-Cell, Adenoma                      | X  X        X  X        X     X                                          |         10 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Adenoma                              |             X           X  X                                             |          7 |
      Carcinoma                            |                                                                          |          1 |
      Bilateral, Adenoma                   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                            X                                             |          2 |
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X     X  X     X  X  X  X     X     X  X  X  X        X  X  X   |         37 |
      Interstitial Cell, Adenoma           |                      X                                      X           X|          7 |
      Tunic, Mesothelioma Malignant        |                                                       X                  |          4 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +  +  +     +  +  +        +  +  +        +                 +         |  21        |
      Leukemia Mononuclear                 |    X                                                                     |          2 |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  48        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  44                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 6| 6| 3| 5| 7| 6| 5| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 0| 3| 3| 0| 6| 5| 7| 8| 3| 7| 6| 1|            |
                                           | 5| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 0| 0| 6| 5| 7| 0| 2| 2| 0| 5| 0| 2| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    .4 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mandibular, Leukemia Mononuclear     |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Undifferentiated Cell Type       |                                                                          |          1 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          1 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  47        |
      Leukemia Mononuclear                 |                                                                         X|          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukemia Mononuclear                 |    X                                                        X           X|          6 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +|  46        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  M  +  M  M  M  +  M  M  M  +  +  M  +  +  +  M  +  +  +  M  +  M|  27        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basal Cell Carcinoma                 |                X                                                         |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                   X      |          3 |
      Subcutaneous Tissue, Sarcoma         |                                        X                                 |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   3        |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Astrocytoma Malignant                |                                                          X               |          1 |
      Granular Cell Tumor Benign           |                                                    X                     |          1 |
      Leukemia Mononuclear                 |                            X                                             |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar/Bronchiolar Adenoma         | X  X                                                        X            |          6 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  45                                                               
NTP Experiment-Test: 05030-01                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 09:45:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 6| 6| 3| 5| 7| 6| 5| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 0| 3| 3| 0| 6| 5| 7| 8| 3| 7| 6| 1|            |
                                           | 5| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 0| 0| 6| 5| 7| 0| 2| 2| 0| 5| 0| 2| 3|            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|     A      |
    .4 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|     L      |
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |    X                       X                                X           X|          7 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Pleura, Mesothelioma Malignant       |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                              +                           |   3        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                          +           +  +|  11        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                      +   |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |                            X                                             |          2 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  47        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Leukemia Mononuclear                 |    X                       X                                X           X|          7 |
      Lymphoma Malignant Undifferentiated  |                                                                          |            |
          Cell Type                        |                                                                          |          1 |
      Mesothelioma Malignant               |    X                                                  X                  |          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  46                                                               
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