National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/4599

TR 396 Mouse Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: IRDC                                                      DATE: 09/18/94   
EXP: 05705                  MONOCHLOROACETIC ACID              TIME: 19:59:13   
TEST: 01              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 60231    
CONT: 05700-05                                                 CAS: 79-11-8     
PATHOLOGIST: D. GOODMAN                      S. EUSTIS                          
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


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NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: IRDC                                                      DATE: 09/18/94  
EXP: 05705                  MONOCHLOROACETIC ACID              TIME: 19:59:13  
TEST: 01              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 60231   
CONT: 05700-05                                                 CAS: 79-11-8    
PATHOLOGIST: D. GOODMAN                      S. EUSTIS                         

                               MONOCHLOROACETIC ACID


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 12     CENSORED DEATHS 2    TERMINAL 46        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      157   455   517   566   627   637   639   652   657   689                 |
 |      702   716                                                                 |
 |  CENSORED DEATHS                                                               |
 |      59    361                                                                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 50 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 21     CENSORED DEATHS 0    TERMINAL 39        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      6     6     11    66    66    126   136   434   542   566                 |
 |      573   581   614   639   659   670   673   674   687   714                 |
 |      716                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 100MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 34     CENSORED DEATHS 5    TERMINAL 21        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      4     63    104   135   149   268   367   424   428   431                 |
 |      434   443   447   447   467   468   495   497   504   528                 |
 |      541   545   553   581   588   594   599   623   645   669                 |
 |      679   695   711   726                                                     |
 |  CENSORED DEATHS                                                               |
 |      18    59    62    190   324                                               |
 |                                                                                |
 ==================================================================================

                               MONOCHLOROACETIC ACID


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0  98.3  98.3  98.3  98.3  96.6  94.9  93.1  84.5  79.3      |
 |           |                                                                    |
 |           |                                                                    |
 |50 MG/KG   |    91.7  88.3  88.3  88.3  88.3  86.7  85.0  80.0  75.0  65.0      |
 |           |                                                                    |
 |           |                                                                    |
 |100MG/KG   |    96.6  91.3  89.5  89.5  85.9  71.2  60.3  51.2  47.5  38.4      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          50 MG/KG         100MG/KG      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       79.3%            65.0%            38.4%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P<0.001          P=0.096          P<0.001       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       584.5            436.1            466.2         |
 |NATURAL DEATHS (C)      |       (44.7)           (61.5)           (32.5)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       682.8            626.5            530.2         |
 |(STANDARD ERROR)        |       (16.6)           (27.9)           (29.2)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                               MONOCHLOROACETIC ACID


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 17     CENSORED DEATHS 1    TERMINAL 42        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      463   511   513   625   627   636   657   671   679   682                 |
 |      683   687   708   709   717   722   724                                   |
 |  CENSORED DEATHS                                                               |
 |      153                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 50 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 20     CENSORED DEATHS 0    TERMINAL 40        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      253   310   390   503   545   545   587   590   591   614                 |
 |      636   640   647   651   656   675   697   701   703   709                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 100MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 13     CENSORED DEATHS 3    TERMINAL 44        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      100   137   182   182   191   584   640   645   664   672                 |
 |      717   723   725                                                           |
 |  CENSORED DEATHS                                                               |
 |      32    66    182                                                           |
 |                                                                                |
 ==================================================================================

                               MONOCHLOROACETIC ACID


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0 100.0 100.0  98.3  94.9  94.9  88.1  71.2      |
 |           |                                                                    |
 |           |                                                                    |
 |50 MG/KG   |   100.0 100.0  98.3  96.7  95.0  95.0  90.0  85.0  75.0  66.7      |
 |           |                                                                    |
 |           |                                                                    |
 |100MG/KG   |   100.0  96.6  91.3  91.3  91.3  91.3  91.3  89.6  84.3  77.3      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          50 MG/KG         100MG/KG      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       71.2%            66.7%            77.3%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.649N         P=0.565          P=0.659N      |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       647.9            582.2            474.0         |
 |NATURAL DEATHS (C)      |       (19.3)           (28.9)           (73.0)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       696.4            680.1            642.0         |
 |(STANDARD ERROR)        |       (11.7)           (13.1)           (26.3)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                       MONOCHLOROACETIC ACID
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        50 MG/KG         = 2
                                                        100MG/KG         = 3

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

         |
         |
  102.31 +
         |12                       1
         | 3        3              1                                              1
         | 22       3      3                                                      1        1
   95.00 +  2        2     3    3                                                          1       1
         |                      3 3                                                                1         1
         |           2        2   3                  3                                                       11
         |                    2 2                    3              3                                         11
   87.69 +                      2                                   3        32                                1 1
         |                                                                   32                 2  2
P        |                                                                                         22            1     1
E        |                                                                                          22                 1 1
R  80.38 +                                                                    3 3                    2     2             1 1
C        |                                                                                                 2   2           1  1
E        |                                                                                                     2   2
N        |                                                                      3   3                              22
T  73.08 +                                                                                                          22
         |                                                                          3   3
S        |                                                                                                           2 2
U        |                                                                              33                             2  2
R  65.77 +                                                                               3    3                           22  2
V        |                                                                                    3 3
I        |
V        |                                                                                      33
A  58.46 +                                                                                       3   3
L        |                                                                                           33
         |                                                                                            3 3
         |                                                                                              33
   51.15 +                                                                                               3  3
         |                                                                                                  3   3
         |                                                                                                      3   3
         |                                                                                                          33
   43.85 +                                                                                                           3  3
         |                                                                                                              3 3
         |                                                                                                                3 3
         |                                                                                                                  3 3
   36.54 +
         |
         -+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+
          0         10         20         30         40         50         60         70         80         90         100       110

                                                                     WEEK

NOTE: 6 obs hidden.

                                                       MONOCHLOROACETIC ACID
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        50 MG/KG         = 2
                                                        100MG/KG         = 3

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                3                       2                                1
      |                  3    3                  2        2                       1     1
      |
      |                       3      3                    2           2                 11
   95 +                                                               2                2 1                 1
      |                                                                                2      2
P     |                              3 3
E     |                                3                                                            3      11
R  90 +                                                                                       2     2       13 1
C     |                                                                                             2 2        1  1
E     |                                                                                                      33
N     |                                                                                                       3  311
T  85 +                                                                                               2  2         11
      |                                                                                                  2  2    33
S     |                                                                                                           3      3
U     |                                                                                                     22      11   33
R  80 +                                                                                                      22      1  1
V     |
I     |                                                                                                                   3 3
V     |                                                                                                       22        11
A  75 +                                                                                                        2   2     11
L     |                                                                                                            2  2
      |
      |                                                                                                               22  1 1
   70 +
      |                                                                                                                22
      |
      |                                                                                                                 2   2
   65 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 3 obs hidden.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.