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TR 396 Rat Pathology Tables

NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97
Route: GAVAGE                                                                                                     Time: 10:11:11




       Facility:  International Research and Development Corp.

       Chemical CAS #:  79-11-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 1| 7| 7| 7| 7| 1| 6| 7| 7| 7| 1| 4| 7| 6| 7| 2| 7| 7| 7| 5|             
                             DAY ON TEST   | 5| 3| 3| 3| 2| 8| 3| 3| 2| 3| 8| 7| 2| 3| 3| 8| 5| 3| 5| 3| 1| 2| 2| 3| 9|             
                                           | 6| 2| 2| 1| 9| 3| 1| 0| 9| 0| 3| 5| 9| 1| 0| 3| 6| 1| 3| 1| 5| 9| 9| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X        X  X                 X|             
      Neoplastic Nodule                    |                                                                X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                       +                  |             
      Fat, Leukemia Mononuclear            |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  M  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                         +|             
      Squamous Cell Papilloma              |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +     +  +  +  +     +  +  +  +        +  M  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Benign              |             X                       X                                    |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  M  +  +     +  +  +  +     +  M  +  +        +  +  +  M  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |    X     X        X     X  X     X  X     X        X  X        X  X  X   |             
      Pars Distalis, Carcinoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 1| 7| 7| 7| 7| 1| 6| 7| 7| 7| 1| 4| 7| 6| 7| 2| 7| 7| 7| 5|             
                             DAY ON TEST   | 5| 3| 3| 3| 2| 8| 3| 3| 2| 3| 8| 7| 2| 3| 3| 8| 5| 3| 5| 3| 1| 2| 2| 3| 9|             
                                           | 6| 2| 2| 1| 9| 3| 1| 0| 9| 0| 3| 5| 9| 1| 0| 3| 6| 1| 3| 1| 5| 9| 9| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Bilateral, C-Cell, Adenoma           |                   X                                                      |             
      C-Cell, Adenoma                      |                                                                          |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |    +  +  +  +     +  M  +  +     M  M  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Adenoma                              |    X                                                                     |             
      Granulosa Cell Tumor Benign          |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Sarcoma Stromal                      |                                                                          |             
      Endometrium, Polyp Stromal           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                                                          |             
      Mandibular, Leukemia Mononuclear     |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
      Mediastinal, Sarcoma                 |                                                             X            |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  M  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X        X  X                 X|             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  +     +  +  +  I     +  +  +  +        +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
      Sarcoma                              |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Fibroadenoma                         |    X  X  X  X     X  X     X     X     X  X                       X      |             
      Fibroadenoma, Multiple               |                                                                      X   |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Fibroma         |                                     X                                    |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 1| 7| 7| 7| 7| 1| 6| 7| 7| 7| 1| 4| 7| 6| 7| 2| 7| 7| 7| 5|             
                             DAY ON TEST   | 5| 3| 3| 3| 2| 8| 3| 3| 2| 3| 8| 7| 2| 3| 3| 8| 5| 3| 5| 3| 1| 2| 2| 3| 9|             
                                           | 6| 2| 2| 1| 9| 3| 1| 0| 9| 0| 3| 5| 9| 1| 0| 3| 6| 1| 3| 1| 5| 9| 9| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |                                                                          |             
      Carcinoma, Early Invasion,           |                                                                          |             
          Metastatic, Pituitary Gland      |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                 X|             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Vomeronasal Organ, Leukemia          |                                                                          |             
          Mononuclear                      |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                        +                                 |             
      Carcinoma                            |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Transitional Epithelium, Carcinoma   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X        X  X                 X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 5| 7| 7| 1| 1| 7| 7| 7| 4| 4| 4| 7| 6| 5| 5| 7| 6| 7| 1| 3| 7| 6| 6|             
                             DAY ON TEST   | 8| 5| 6| 3| 2| 8| 8| 3| 3| 3| 5| 5| 5| 3| 2| 2| 5| 2| 3| 3| 8| 4| 2| 9| 9|             
                                           | 3| 6| 5| 1| 9| 3| 3| 0| 0| 0| 6| 6| 6| 2| 6| 0| 8| 9| 7| 1| 3| 4| 9| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +  +  +        +  +  +           +  +  +  +  +  I  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                        X     X  X  X              X  X  X|             
      Neoplastic Nodule                    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                 +     +                  |             
      Fat, Leukemia Mononuclear            |                                                 X                        |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                 X                       X|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                 X                        |             
                                            __________________________________________________________________________|             
   Stomach                                 |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +  +  +        +  +  +           +  +  M  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                 X                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                 X                        |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |       +  +  +        +  +  +           +  +  +     +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                 X                    X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X  X   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       M  M  +        +  +  +           +  +  M  +  +  +  +     M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
      Pars Distalis, Adenoma               |                      X     X           X           X  X  X        X      |             
      Pars Distalis, Carcinoma             |       X     X                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 5| 7| 7| 1| 1| 7| 7| 7| 4| 4| 4| 7| 6| 5| 5| 7| 6| 7| 1| 3| 7| 6| 6|             
                             DAY ON TEST   | 8| 5| 6| 3| 2| 8| 8| 3| 3| 3| 5| 5| 5| 3| 2| 2| 5| 2| 3| 3| 8| 4| 2| 9| 9|             
                                           | 3| 6| 5| 1| 9| 3| 3| 0| 0| 0| 6| 6| 6| 2| 6| 0| 8| 9| 7| 1| 3| 4| 9| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Bilateral, C-Cell, Adenoma           |                                                                          |             
      C-Cell, Adenoma                      |             X                                   X     X                  |             
      C-Cell, Carcinoma                    |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |       +  +  +        +  +  M           +  I  +  I  +  I  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Adenoma                              |                                                                          |             
      Granulosa Cell Tumor Benign          |                      X                                                   |             
      Leukemia Mononuclear                 |                                                 X                 X      |             
                                            __________________________________________________________________________|             
   Uterus                                  |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Sarcoma Stromal                      |                                                                         X|             
      Endometrium, Polyp Stromal           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X  X|             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                                                          |             
      Mandibular, Leukemia Mononuclear     |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
      Mediastinal, Sarcoma                 |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                 X                 X      |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                        X     X  X  X              X  X  X|             
                                            __________________________________________________________________________|             
   Thymus                                  |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                 X                 X      |             
      Sarcoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Carcinoma                            |       X                                                                  |             
      Fibroadenoma                         |          X              X  X              X        X                     |             
      Fibroadenoma, Multiple               |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 5| 7| 7| 1| 1| 7| 7| 7| 4| 4| 4| 7| 6| 5| 5| 7| 6| 7| 1| 3| 7| 6| 6|             
                             DAY ON TEST   | 8| 5| 6| 3| 2| 8| 8| 3| 3| 3| 5| 5| 5| 3| 2| 2| 5| 2| 3| 3| 8| 4| 2| 9| 9|             
                                           | 3| 6| 5| 1| 9| 3| 3| 0| 0| 0| 6| 6| 6| 2| 6| 0| 8| 9| 7| 1| 3| 4| 9| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Astrocytoma Malignant                |                                                                          |             
      Carcinoma, Early Invasion,           |                                                                          |             
          Metastatic, Pituitary Gland      |       X                                                                  |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                 +                        |             
      Leukemia Mononuclear                 |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                              X  X                 X  X   |             
                                            __________________________________________________________________________|             
   Nose                                    |       +  +  +        +  M  +           +  +  +  +  +  +  +     +  +  +  +|             
      Vomeronasal Organ, Leukemia          |                                                                          |             
          Mononuclear                      |                                                 X                        |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +                                                   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +  +  +        +  +  +           +  +  M  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                 X                        |             
      Transitional Epithelium, Carcinoma   |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                        X     X  X  X              X  X  X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 7| 6| 7| 1| 7| 7| 6| 7| 1| 7| 7| 7| 7| 1| 6| 7| 7| 7|              |            |
                             DAY ON TEST   | 5| 2| 2| 9| 3| 8| 2| 3| 7| 3| 8| 3| 3| 3| 3| 8| 9| 3| 3| 3|              |            |
                                           | 6| 9| 9| 3| 1| 3| 9| 0| 2| 1| 3| 2| 2| 0| 2| 3| 0| 2| 2| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     A      |
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |     L      |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Leukemia Mononuclear                 |    X     X              X        X              X                        |         16 |
      Neoplastic Nodule                    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                       +                  |   4        |
      Fat, Leukemia Mononuclear            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Leukemia Mononuclear                 |                                                 X                        |          2 |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  51        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Squamous Cell Papilloma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |    +  +  +  +        +  +  +     +  +  +  +     +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Leukemia Mononuclear                 |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Leukemia Mononuclear                 |                                                 X                        |          3 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  52        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Pheochromocytoma Benign              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   8                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 7| 6| 7| 1| 7| 7| 6| 7| 1| 7| 7| 7| 7| 1| 6| 7| 7| 7|              |            |
                             DAY ON TEST   | 5| 2| 2| 9| 3| 8| 2| 3| 7| 3| 8| 3| 3| 3| 3| 8| 9| 3| 3| 3|              |            |
                                           | 6| 9| 9| 3| 1| 3| 9| 0| 2| 1| 3| 2| 2| 0| 2| 3| 0| 2| 2| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     A      |
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |     L      |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  +  +  +     M  +  +  +     +  +  M  +     +  +  +  +               |  43        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Leukemia Mononuclear                 |                                                 X                        |          2 |
      Pars Distalis, Adenoma               |          X        X                 X              X  X  X               |         26 |
      Pars Distalis, Carcinoma             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Bilateral, C-Cell, Adenoma           |                                                                          |          1 |
      C-Cell, Adenoma                      |             X                                   X                        |          5 |
      C-Cell, Carcinoma                    |                                           X                              |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |    +  +  +  +     +  +  +  M     +  +  +  +     M  +  +  +               |  44        |
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Adenoma                              |                                                                          |          1 |
      Granulosa Cell Tumor Benign          |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Sarcoma Stromal                      |                                                                          |          1 |
      Endometrium, Polyp Stromal           |                            X                                             |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Axillary, Leukemia Mononuclear       |                                                 X                        |          1 |
      Iliac, Leukemia Mononuclear          |                         X                                                |          1 |
      Mandibular, Leukemia Mononuclear     |                                                 X                        |          1 |
      Mediastinal, Leukemia Mononuclear    |                                                 X                        |          1 |
      Mediastinal, Sarcoma                 |                                                                          |          1 |
      Renal, Leukemia Mononuclear          |                         X                                                |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  52        |
      Leukemia Mononuclear                 |                                                 X                        |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Leukemia Mononuclear                 |    X     X              X        X              X                        |         16 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +  +  +     +  M  +  +     +  +  +  +     +  +  +  +               |  51        |
      Leukemia Mononuclear                 |                                                 X                        |          4 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   9                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 7| 6| 7| 1| 7| 7| 6| 7| 1| 7| 7| 7| 7| 1| 6| 7| 7| 7|              |            |
                             DAY ON TEST   | 5| 2| 2| 9| 3| 8| 2| 3| 7| 3| 8| 3| 3| 3| 3| 8| 9| 3| 3| 3|              |            |
                                           | 6| 9| 9| 3| 1| 3| 9| 0| 2| 1| 3| 2| 2| 0| 2| 3| 0| 2| 2| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     A      |
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |     L      |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Sarcoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Carcinoma                            |             X                                                            |          2 |
      Fibroadenoma                         |          X  X     X  X  X  X           X  X     X        X               |         26 |
      Fibroadenoma, Multiple               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Astrocytoma Malignant                |                   X        X                                             |          2 |
      Carcinoma, Early Invasion,           |                                                                          |            |
          Metastatic, Pituitary Gland      |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                 X                        |          1 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Leukemia Mononuclear                 |                         X                       X                        |          8 |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  52        |
      Vomeronasal Organ, Leukemia          |                                                                          |            |
          Mononuclear                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +              +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  10                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 7| 6| 7| 1| 7| 7| 6| 7| 1| 7| 7| 7| 7| 1| 6| 7| 7| 7|              |            |
                             DAY ON TEST   | 5| 2| 2| 9| 3| 8| 2| 3| 7| 3| 8| 3| 3| 3| 3| 8| 9| 3| 3| 3|              |            |
                                           | 6| 9| 9| 3| 1| 3| 9| 0| 2| 1| 3| 2| 2| 0| 2| 3| 0| 2| 2| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     A      |
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |     L      |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  52        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Transitional Epithelium, Carcinoma   |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Leukemia Mononuclear                 |    X     X              X        X              X                        |         16 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  11                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 4| 7| 7| 6| 1| 1| 5| 6| 7| 1| 1| 4| 7| 6| 5| 7| 6| 7| 7| 2| 4| 4| 4| 7|             
                             DAY ON TEST   | 4| 5| 0| 3| 6| 8| 8| 6| 3| 3| 8| 8| 5| 3| 1| 3| 3| 3| 3| 0| 9| 5| 5| 5| 2|             
                                           | 3| 6| 2| 0| 2| 3| 3| 8| 9| 1| 3| 3| 6| 0| 0| 5| 1| 7| 1| 6| 9| 6| 6| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    15 MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | M     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Leukemia Mononuclear                 |       X  X  X        X                                   X               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Leukemia Mononuclear                 |       X  X                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Leukemia Mononuclear                 |                      X                                                   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | M     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Leukemia Mononuclear                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M     +  +  +        M  +  M           +  +  M  +  +  M  +  +           +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Leukemia Mononuclear                 |       X  X                                                               |             
      Pars Distalis, Adenoma               |                                        X     X  X  X        X            |             
      Pars Distalis, Carcinoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | M     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      C-Cell, Adenoma                      |                      X                             X                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 4| 7| 7| 6| 1| 1| 5| 6| 7| 1| 1| 4| 7| 6| 5| 7| 6| 7| 7| 2| 4| 4| 4| 7|             
                             DAY ON TEST   | 4| 5| 0| 3| 6| 8| 8| 6| 3| 3| 8| 8| 5| 3| 1| 3| 3| 3| 3| 0| 9| 5| 5| 5| 2|             
                                           | 3| 6| 2| 0| 2| 3| 3| 8| 9| 1| 3| 3| 6| 0| 0| 5| 1| 7| 1| 6| 9| 6| 6| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    15 MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +     +  +  +        +  M  +           +  M  +  +  +  +  M  +           M|             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Ovary                                   | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Granulosa Cell Tumor Malignant       |                      X                                                   |             
      Leukemia Mononuclear                 |       X  X                                                               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Leukemia Mononuclear                 |          X                                                               |             
      Endometrium, Polyp Stromal           |          X                                   X           X               |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Leukemia Mononuclear                 |          X  X        X                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Axillary, Leukemia Mononuclear       |          X                                                               |             
      Deep Cervical, Leukemia Mononuclear  |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Leukemia Mononuclear                 |       X              X                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Leukemia Mononuclear                 |       X  X  X        X                                   X               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +  +  +        +  +  +           +  +  +  +  +  I  +  +           +|             
      Leukemia Mononuclear                 |       X  X                                                               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Carcinoma                            |                                                 X                        |             
      Fibroadenoma                         |          X                                X  X           X               |             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Carcinoma                            |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Astrocytoma Malignant                |                                                                          |             
      Carcinoma, Early Invasion,           |                                                                          |             
          Metastatic, Pituitary Gland      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 4| 7| 7| 6| 1| 1| 5| 6| 7| 1| 1| 4| 7| 6| 5| 7| 6| 7| 7| 2| 4| 4| 4| 7|             
                             DAY ON TEST   | 4| 5| 0| 3| 6| 8| 8| 6| 3| 3| 8| 8| 5| 3| 1| 3| 3| 3| 3| 0| 9| 5| 5| 5| 2|             
                                           | 3| 6| 2| 0| 2| 3| 3| 8| 9| 1| 3| 3| 6| 0| 0| 5| 1| 7| 1| 6| 9| 6| 6| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    15 MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Leukemia Mononuclear                 |       X  X           X                                                   |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                                                                        |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                         +                                                |             
      Carcinoma                            |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Hemangiosarcoma                      |                                                       X                  |             
      Leukemia Mononuclear                 |          X                                               X               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +        +  M  +           +  +  +  +  +  +  +  +           +|             
      Leukemia Mononuclear                 |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Leukemia Mononuclear                 |       X  X  X        X                                   X               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 7| 5| 7| 1| 4| 7| 7| 7| 1| 6| 6| 7| 7| 0| 1| 7| 6| 7| 2| 5| 5| 6| 6|             
                             DAY ON TEST   | 8| 2| 3| 8| 3| 8| 5| 2| 3| 3| 8| 7| 7| 3| 3| 0| 8| 3| 7| 3| 4| 0| 7| 3| 5|             
                                           | 3| 7| 2| 4| 0| 3| 6| 9| 2| 2| 3| 4| 7| 1| 2| 3| 3| 0| 9| 1| 3| 4| 5| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    15 MG/KG                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +        +  +  +     +  +  +  +  M     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X  X                             X                    X  X      |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +  +        +  M  +     +  +  +  +  +     +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |       X     X        X  X  X     X                 X                 X  X|             
      Pars Distalis, Carcinoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 7| 5| 7| 1| 4| 7| 7| 7| 1| 6| 6| 7| 7| 0| 1| 7| 6| 7| 2| 5| 5| 6| 6|             
                             DAY ON TEST   | 8| 2| 3| 8| 3| 8| 5| 2| 3| 3| 8| 7| 7| 3| 3| 0| 8| 3| 7| 3| 4| 0| 7| 3| 5|             
                                           | 3| 7| 2| 4| 0| 3| 6| 9| 2| 2| 3| 4| 7| 1| 2| 3| 3| 0| 9| 1| 3| 4| 5| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    15 MG/KG                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |    M  +  +  +        +  +  M     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Granulosa Cell Tumor Malignant       |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Endometrium, Polyp Stromal           |                         X                          X  X        X         |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  M  +|             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Deep Cervical, Leukemia Mononuclear  |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |          X                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  M  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X  X                             X                    X  X      |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                  X                                       |             
      Fibroadenoma                         |    X        X           X  X           X           X  X              X   |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                         X|             
      Subcutaneous Tissue, Fibrosarcoma    |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                |                                                                          |             
      Carcinoma, Early Invasion,           |                                                                          |             
          Metastatic, Pituitary Gland      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 7| 5| 7| 1| 4| 7| 7| 7| 1| 6| 6| 7| 7| 0| 1| 7| 6| 7| 2| 5| 5| 6| 6|             
                             DAY ON TEST   | 8| 2| 3| 8| 3| 8| 5| 2| 3| 3| 8| 7| 7| 3| 3| 0| 8| 3| 7| 3| 4| 0| 7| 3| 5|             
                                           | 3| 7| 2| 4| 0| 3| 6| 9| 2| 2| 3| 4| 7| 1| 2| 3| 3| 0| 9| 1| 3| 4| 5| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    15 MG/KG                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X                                                        X      |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                           X                              |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            M                                             |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X  X                             X                    X  X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 4| 6| 6| 5| 1| 4| 7| 7| 6| 5| 6| 6| 5| 6| 5| 6| 7| 7| 7|              |            |
                             DAY ON TEST   | 8| 9| 4| 0| 9| 8| 5| 2| 2| 3| 3| 4| 4| 8| 7| 5| 2| 2| 2| 3|              |            |
                                           | 3| 4| 7| 0| 6| 3| 6| 9| 5| 0| 9| 4| 4| 8| 2| 0| 4| 9| 9| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |     A      |
    15 MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     L      |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +  +  +        +  +  +  M  +  +  +  +  +  +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 |       X  X                                   X           X               |         14 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +  +  +        +  +  +  +  +  +  M  +  +  +  +  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  52        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  +  +  +        +  +  +  M  +  +  M  +  +  +  +  M  +               |  43        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 |          X                                               X               |          4 |
      Pars Distalis, Adenoma               |    X        X        X  X                 X                              |         19 |
      Pars Distalis, Carcinoma             |                                  X  X                                    |          2 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  52        |
      C-Cell, Adenoma                      |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  18                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 4| 6| 6| 5| 1| 4| 7| 7| 6| 5| 6| 6| 5| 6| 5| 6| 7| 7| 7|              |            |
                             DAY ON TEST   | 8| 9| 4| 0| 9| 8| 5| 2| 2| 3| 3| 4| 4| 8| 7| 5| 2| 2| 2| 3|              |            |
                                           | 3| 4| 7| 0| 6| 3| 6| 9| 5| 0| 9| 4| 4| 8| 2| 0| 4| 9| 9| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |     A      |
    15 MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     L      |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |    M  +  +  +        +  +  +  +  +  +  +  M  +  +  +  +  +               |  45        |
      Carcinoma                            |                      X                                                   |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Granulosa Cell Tumor Malignant       |                                                                          |          1 |
      Leukemia Mononuclear                 |       X                                                                  |          3 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Endometrium, Polyp Stromal           |                                                                          |          7 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 |          X                                                               |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  52        |
      Axillary, Leukemia Mononuclear       |                                              X                           |          2 |
      Deep Cervical, Leukemia Mononuclear  |                                              X                           |          1 |
      Iliac, Leukemia Mononuclear          |                                              X                           |          1 |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  52        |
      Leukemia Mononuclear                 |                                              X                           |          4 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 |       X  X                                   X           X               |         14 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +  +  I        +  +  +  +  +  +  +  +  +  +  +  +  +               |  51        |
      Leukemia Mononuclear                 |                                              X                           |          4 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Carcinoma                            |                                     X                                    |          3 |
      Fibroadenoma                         |    X        X           X     X  X  X  X  X        X  X  X               |         23 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +  +  +        +  +  +  +  +  +  I  +  +  +  +  +  +               |  52        |
      Carcinoma                            |                                                       X                  |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  19                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 4| 6| 6| 5| 1| 4| 7| 7| 6| 5| 6| 6| 5| 6| 5| 6| 7| 7| 7|              |            |
                             DAY ON TEST   | 8| 9| 4| 0| 9| 8| 5| 2| 2| 3| 3| 4| 4| 8| 7| 5| 2| 2| 2| 3|              |            |
                                           | 3| 4| 7| 0| 6| 3| 6| 9| 5| 0| 9| 4| 4| 8| 2| 0| 4| 9| 9| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |     A      |
    15 MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |     L      |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Astrocytoma Malignant                |                            X                                             |          1 |
      Carcinoma, Early Invasion,           |                                                                          |            |
          Metastatic, Pituitary Gland      |                                  X                                       |          1 |
      Leukemia Mononuclear                 |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 |                                              X           X               |          7 |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                                   +           +               |   4        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Leukemia Mononuclear                 |       X                                                                  |          4 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  52        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 |       X  X                                   X           X               |         14 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  20                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 6| 7| 7| 1| 1| 2| 5| 7| 1| 3| 7| 7| 7| 1| 4| 7| 5| 6| 1| 4| 4| 6| 7|             
                             DAY ON TEST   | 8| 5| 1| 3| 3| 8| 8| 8| 9| 2| 8| 4| 3| 3| 3| 8| 5| 0| 9| 4| 8| 5| 5| 7| 3|             
                                           | 3| 6| 6| 1| 1| 3| 3| 3| 9| 9| 3| 0| 1| 1| 0| 3| 6| 3| 7| 7| 3| 6| 6| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    30 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +  +  +        +  I  +     +  +  +  +        +  +  +           +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +  +  +        I  M  +     +  +  +  +        +  +  +           +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Leukemia Mononuclear                 |       X                                            X     X           X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                      +   |             
      Squamous Cell Papilloma              |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
                                            __________________________________________________________________________|             
   Heart                                   |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Leukemia Mononuclear                 |       X                                                              X   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Carcinoma                            |                                           X                              |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +  +  +        +  +  +     M  +  +  +        +  +  I           +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |                                        X           X  X  X               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 6| 7| 7| 1| 1| 2| 5| 7| 1| 3| 7| 7| 7| 1| 4| 7| 5| 6| 1| 4| 4| 6| 7|             
                             DAY ON TEST   | 8| 5| 1| 3| 3| 8| 8| 8| 9| 2| 8| 4| 3| 3| 3| 8| 5| 0| 9| 4| 8| 5| 5| 7| 3|             
                                           | 3| 6| 6| 1| 1| 3| 3| 3| 9| 9| 3| 0| 1| 1| 0| 3| 6| 3| 7| 7| 3| 6| 6| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    30 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Adenoma                      |                                                                          |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Sarcoma                              |       X                                                                  |             
                                            __________________________________________________________________________|             
   Ovary                                   |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Endometrium, Polyp Stromal           |          X              X                          X     X               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                                    X                     |             
      Mandibular, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Leukemia Mononuclear                 |       X                                            X     X           X   |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +  +  +        +  I  I     +  +  M  +        +  +  +           +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Carcinoma                            |                                                                          |             
      Fibroadenoma                         |                            X        X     X              X              X|             
      Fibroadenoma, Multiple               |                                                                      X   |             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Keratoacanthoma                      |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 6| 7| 7| 1| 1| 2| 5| 7| 1| 3| 7| 7| 7| 1| 4| 7| 5| 6| 1| 4| 4| 6| 7|             
                             DAY ON TEST   | 8| 5| 1| 3| 3| 8| 8| 8| 9| 2| 8| 4| 3| 3| 3| 8| 5| 0| 9| 4| 8| 5| 5| 7| 3|             
                                           | 3| 6| 6| 1| 1| 3| 3| 3| 9| 9| 3| 0| 1| 1| 0| 3| 6| 3| 7| 7| 3| 6| 6| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    30 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Nose                                    |       +  +  +        +  A  +     +  +  +  +        +  +  +           +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                                             |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +  +  +        +  +  +     +  +  +  +        +  +  +           M  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Leukemia Mononuclear                 |       X                                            X     X           X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 2| 7| 7| 7| 4| 7| 7| 5| 7| 2| 2| 4| 5| 7| 4| 7| 7| 7| 7| 3| 3| 5| 6| 7|             
                             DAY ON TEST   | 8| 7| 2| 3| 3| 5| 3| 2| 9| 3| 5| 5| 5| 3| 3| 5| 3| 3| 3| 3| 3| 5| 1| 6| 1|             
                                           | 3| 0| 9| 2| 0| 6| 0| 9| 3| 2| 3| 7| 6| 9| 0| 6| 1| 2| 2| 0| 1| 1| 2| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    30 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +     +  +  +  +  M  +     +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +     +  +  +  +  A  +     +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +     +  +  +  +  A  +     +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +     +  +  +  +  A  +     +  +     +  +  +  +  A  A  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +     +  +  +  +  A  +     +  +     +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X           X  X              X              X                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X  X                                                |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +  +     M  M  +  +  +  +     M  +     +  +  +  +  +  +  M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
      Pars Distalis, Adenoma               |       X  X        X  X                 X                 X           X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 2| 7| 7| 7| 4| 7| 7| 5| 7| 2| 2| 4| 5| 7| 4| 7| 7| 7| 7| 3| 3| 5| 6| 7|             
                             DAY ON TEST   | 8| 7| 2| 3| 3| 5| 3| 2| 9| 3| 5| 5| 5| 3| 3| 5| 3| 3| 3| 3| 3| 5| 1| 6| 1|             
                                           | 3| 0| 9| 2| 0| 6| 0| 9| 3| 2| 3| 7| 6| 9| 0| 6| 1| 2| 2| 0| 1| 1| 2| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    30 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Adenoma                      |                      X                                                   |             
      C-Cell, Carcinoma                    |                   X                                                  X   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X  X                                                |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Endometrium, Polyp Stromal           |                      X                                            X      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                                                          |             
      Mandibular, Leukemia Mononuclear     |                      X                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X           X  X              X              X                  |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  I  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X  X                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +     +  +  +  +  +  +     +  M     +  +  +  +  +  I  +  +  +|             
      Carcinoma                            |                                                 X                        |             
      Fibroadenoma                         |       X     X     X     X                          X                 X   |             
      Fibroadenoma, Multiple               |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                                                          X               |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 2| 7| 7| 7| 4| 7| 7| 5| 7| 2| 2| 4| 5| 7| 4| 7| 7| 7| 7| 3| 3| 5| 6| 7|             
                             DAY ON TEST   | 8| 7| 2| 3| 3| 5| 3| 2| 9| 3| 5| 5| 5| 3| 3| 5| 3| 3| 3| 3| 3| 5| 1| 6| 1|             
                                           | 3| 0| 9| 2| 0| 6| 0| 9| 3| 2| 3| 7| 6| 9| 0| 6| 1| 2| 2| 0| 1| 1| 2| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    30 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X              X                                 |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  M     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +     +  +  +  +  M  +     +  +     M  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X  X                                                |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |          X           X  X              X              X                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 5| 5| 6| 2| 4| 7| 7| 7| 1| 4| 6| 7| 7| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 8| 8| 6| 8| 8| 9| 9| 2| 2| 2| 8| 5| 8| 2| 2| 3| 3| 3| 3| 3|              |            |
                                           | 3| 3| 8| 2| 2| 4| 7| 9| 2| 9| 3| 8| 2| 9| 4| 1| 2| 1| 0| 1|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |     A      |
    30 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +               |  51        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |       +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       A  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +               |  48        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       A  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 |             X                       X        X           X               |         13 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                    +                     |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +  +  +  M  +  +  I  +     +  +  +  +  +  +  +  +  +               |  51        |
      Leukemia Mononuclear                 |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 |                                              X                           |          2 |
                                            __________________________________________________________________________|____________|
   Stomach                                 |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |       +                                         +                        |   3        |
      Squamous Cell Papilloma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 |             X                                X                           |          6 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |       +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +               |  52        |
      Adenoma                              |             X                                                            |          1 |
      Leukemia Mononuclear                 |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +  +  +  M  +  +  I  +     +  +  +  +  +  +  +  +  +               |  51        |
      Carcinoma                            |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  27                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 5| 5| 6| 2| 4| 7| 7| 7| 1| 4| 6| 7| 7| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 8| 8| 6| 8| 8| 9| 9| 2| 2| 2| 8| 5| 8| 2| 2| 3| 3| 3| 3| 3|              |            |
                                           | 3| 3| 8| 2| 2| 4| 7| 9| 2| 9| 3| 8| 2| 9| 4| 1| 2| 1| 0| 1|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |     A      |
    30 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +  +  +  M  +  +  +  M     M  +  +  M  +  +  +  +  +               |  42        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 |                                              X           X               |          3 |
      Pars Distalis, Adenoma               |          X              X              X  X     X        X               |         17 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +  +  +  +  +  +  +  +     M  +  +  +  +  +  +  +  +               |  52        |
      C-Cell, Adenoma                      |                      X                          X                        |          3 |
      C-Cell, Carcinoma                    |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |       +  +  M  +  M  +  +  +     M  +  +  +  M  +  +  M  +               |  48        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 |                                              X                           |          3 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 |                                     X                                    |          1 |
      Endometrium, Polyp Stromal           |             X        X                 X                                 |          9 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 |             X                                            X               |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Axillary, Leukemia Mononuclear       |                                              X                           |          1 |
      Iliac, Leukemia Mononuclear          |                                                                          |          1 |
      Mandibular, Leukemia Mononuclear     |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 |                                              X           X               |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 |             X                       X        X           X               |         13 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |       I  +  +  +  +  +  +  I     +  +  M  I  +  +  +  +  M               |  44        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  51        |
      Carcinoma                            |             X                                                            |          2 |
      Fibroadenoma                         |          X              X  X     X  X  X     X  X  X  X                  |         21 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  28                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 5| 5| 6| 2| 4| 7| 7| 7| 1| 4| 6| 7| 7| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 8| 8| 6| 8| 8| 9| 9| 2| 2| 2| 8| 5| 8| 2| 2| 3| 3| 3| 3| 3|              |            |
                                           | 3| 3| 8| 2| 2| 4| 7| 9| 2| 9| 3| 8| 2| 9| 4| 1| 2| 1| 0| 1|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |     A      |
    30 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Fibroadenoma, Multiple               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +  +  +  +  +  +  M  +     +  +  +  +  +  +  +  +  +               |  52        |
      Keratoacanthoma                      |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                       X                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 |                                              X                           |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 |             X                                X                           |          5 |
                                            __________________________________________________________________________|____________|
   Nose                                    |       A  +  +  A  A  +  +  +     +  +  +  +  +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                    +                     |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +               |  52        |
      Leukemia Mononuclear                 |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +  +  +  +  +  +  I  +     +  +  +  +  +  +  +  +  +               |  49        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 |             X                       X        X           X               |         13 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  29                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 7| 7| 1| 1| 2| 7| 5| 3| 5| 7| 7| 6| 7| 7| 7| 6| 7| 1| 4| 4| 7| 5|             
                             DAY ON TEST   | 5| 5| 3| 3| 0| 8| 8| 9| 2| 8| 5| 1| 3| 3| 9| 1| 3| 2| 7| 3| 8| 4| 5| 3| 8|             
                                           | 6| 6| 2| 2| 5| 3| 3| 1| 9| 4| 0| 2| 1| 2| 3| 8| 2| 9| 4| 0| 3| 7| 6| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +  +  +        A  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |       X     X              X     X        X  X     X                    X|             
      Neoplastic Nodule                    |                                        X                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Adenoma                              |                                        X                                 |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Heart                                   |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |                                  X           X                           |             
      Pheochromocytoma Malignant           |                                           X                              |             
      Pheochromocytoma Benign              |                         X           X              X     X              X|             
      Bilateral, Pheochromocytoma Benign   |       X                                                                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Adenoma                              |             X                          X           X                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |                                  X           X                           |             
      Pars Distalis, Adenoma               |                                     X              X  X              X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 7| 7| 1| 1| 2| 7| 5| 3| 5| 7| 7| 6| 7| 7| 7| 6| 7| 1| 4| 4| 7| 5|             
                             DAY ON TEST   | 5| 5| 3| 3| 0| 8| 8| 9| 2| 8| 5| 1| 3| 3| 9| 1| 3| 2| 7| 3| 8| 4| 5| 3| 8|             
                                           | 6| 6| 2| 2| 5| 3| 3| 1| 9| 4| 0| 2| 1| 2| 3| 8| 2| 9| 4| 0| 3| 7| 6| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Adenoma                      |          X                       X              X                        |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Mesothelioma Benign                  |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     M  +|             
      Squamous Cell Papilloma              |                                     X                                    |             
                                            __________________________________________________________________________|             
   Prostate                                |       +  +  +        +  +  +  +  +  +  +  +  +  M  +  +  +     +     M  I|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |       M  M  M        M  M  M  M  M  M  M  M  M  M  M  M  M     M     M  M|             
                                            __________________________________________________________________________|             
   Testes                                  |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Mesothelioma Malignant               |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma|       X  X  X           X           X  X  X  X  X     X              X   |             
      Interstitial Cell, Adenoma           |                            X     X                       X     X        X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |                                  X           X                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Inguinal, Leukemia Mononuclear       |                                                                          |             
      Mandibular, Leukemia Mononuclear     |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |       X     X              X     X        X  X     X                    X|             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |             X                                                            |             
                                            __________________________________________________________________________|             
   Thymus                                  |       I  I  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Adenoma                              |                                                                          |             
      Fibroadenoma                         |                                        X                             X   |             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Keratoacanthoma                      |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 7| 7| 1| 1| 2| 7| 5| 3| 5| 7| 7| 6| 7| 7| 7| 6| 7| 1| 4| 4| 7| 5|             
                             DAY ON TEST   | 5| 5| 3| 3| 0| 8| 8| 9| 2| 8| 5| 1| 3| 3| 9| 1| 3| 2| 7| 3| 8| 4| 5| 3| 8|             
                                           | 6| 6| 2| 2| 5| 3| 3| 1| 9| 4| 0| 2| 1| 2| 3| 8| 2| 9| 4| 0| 3| 7| 6| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Astrocytoma Malignant                |                                                          X               |             
      Leukemia Mononuclear                 |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Carcinoma, Metastatic, Zymbal's Gland|             X                                                            |             
      Leukemia Mononuclear                 |       X     X              X                 X                           |             
      Liposarcoma                          |                                                                X         |             
                                            __________________________________________________________________________|             
   Nose                                    |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Carcinoma              |                               X                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                          +                  |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |             +                                                            |             
      Carcinoma                            |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |                                              X     X                     |             
      Renal Tubule, Adenoma                |             X                                                            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |       X     X              X     X        X  X     X                    X|             
      Mesothelioma Benign                  |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 1| 7| 6| 6| 1| 4| 7| 7| 7| 1| 1| 5| 7| 6| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 8| 2| 5| 9| 8| 5| 1| 1| 3| 8| 8| 3| 3| 2| 3| 3| 2| 2| 3| 8| 2| 2| 3| 3|             
                                           | 3| 3| 9| 6| 1| 3| 6| 4| 5| 1| 3| 3| 8| 2| 1| 1| 2| 9| 9| 1| 3| 9| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +  +  +        +  +  +        +  +  M  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |             X        X     X           X     X        X        X        X|             
      Neoplastic Nodule                    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                               |             
      Mesothelioma Malignant               |          X                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                      X                                                   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +  +  +        +  M  +        +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   |       +  +  +        +  +  +        +  +  +  +  +  +  M  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +  +  M        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                            X                       X              X      |             
      Bilateral, Pheochromocytoma Benign   |                         X                                                |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +  +  +        +  +  +        +  +  +  +  M  +  +  +     +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                  X|             
      Pars Distalis, Adenoma               |             X                             X     X        X        X      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 1| 7| 6| 6| 1| 4| 7| 7| 7| 1| 1| 5| 7| 6| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 8| 2| 5| 9| 8| 5| 1| 1| 3| 8| 8| 3| 3| 2| 3| 3| 2| 2| 3| 8| 2| 2| 3| 3|             
                                           | 3| 3| 9| 6| 1| 3| 6| 4| 5| 1| 3| 3| 8| 2| 1| 1| 2| 9| 9| 1| 3| 9| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Adenoma                      |                                                    X                 X   |             
      C-Cell, Carcinoma                    |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Mesothelioma Benign                  |                                                                          |             
      Mesothelioma Malignant               |          X                                                               |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  M  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |       M  M  M        M  M  M        +  M  M  M  M  M  M  M     M  M  M  M|             
                                            __________________________________________________________________________|             
   Testes                                  |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Mesothelioma Malignant               |          X                                                               |             
      Bilateral, Interstitial Cell, Adenoma|       X  X  X           X  X        X  X     X  X  X     X     X  X  X  X|             
      Interstitial Cell, Adenoma           |                      X                    X           X                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                      X                       X                          X|             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Inguinal, Leukemia Mononuclear       |                                                                          |             
      Mandibular, Leukemia Mononuclear     |                                                                         X|             
      Mediastinal, Leukemia Mononuclear    |                                                                         X|             
      Pancreatic, Leukemia Mononuclear     |                                                                         X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |             X        X     X           X     X     X           X        X|             
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |             
          Primary Site                     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |       I  I  +        +  +  +        +  +  +  +  +  +  +  +     +  I  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Adenoma                              |                                                                          |             
      Fibroadenoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Keratoacanthoma                      |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 1| 7| 6| 6| 1| 4| 7| 7| 7| 1| 1| 5| 7| 6| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 8| 2| 5| 9| 8| 5| 1| 1| 3| 8| 8| 3| 3| 2| 3| 3| 2| 2| 3| 8| 2| 2| 3| 3|             
                                           | 3| 3| 9| 6| 1| 3| 6| 4| 5| 1| 3| 3| 8| 2| 1| 1| 2| 9| 9| 1| 3| 9| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Astrocytoma Malignant                |                                                                          |             
      Leukemia Mononuclear                 |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |             
      Leukemia Mononuclear                 |             X              X                 X                          X|             
      Liposarcoma                          |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  M  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Carcinoma              |          X                                                               |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                    +                     |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Leukemia Mononuclear                 |             X        X     X           X     X     X  X        X        X|             
      Mesothelioma Benign                  |                                                                          |             
      Mesothelioma Malignant               |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 1| 5| 5| 7| 6| 4| 6| 6| 7| 5| 4| 4| 7| 6| 7|              |            |
                             DAY ON TEST   | 5| 3| 3| 3| 2| 8| 0| 7| 3| 2| 5| 3| 9| 2| 8| 3| 5| 3| 7| 3|              |            |
                                           | 6| 0| 1| 0| 8| 3| 6| 5| 0| 9| 6| 1| 1| 5| 4| 6| 6| 0| 9| 0|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +  +  +     +  +  +  A     +  +  +  +  +     +  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +  +  +     +  +  +  A     +  +  +  +  +     +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
      Leukemia Mononuclear                 |          X  X     X  X  X           X  X  X  X     X     X               |         27 |
      Neoplastic Nodule                    |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                                                   |   2        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +     +  +  +  +     +  +  M  +  +     +  +  +               |  52        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |                                              X                           |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +  +  +     +  +  +  +     +  +  +  +  +     +     +               |  52        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  52        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  52        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  51        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |    X        X        X                                   X               |         12 |
      Bilateral, Pheochromocytoma Benign   |                         X           X  X                                 |          5 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +  +     +  +  +  +     +  +  M  +  +     +  +  +               |  52        |
      Adenoma                              |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  36                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 1| 5| 5| 7| 6| 4| 6| 6| 7| 5| 4| 4| 7| 6| 7|              |            |
                             DAY ON TEST   | 5| 3| 3| 3| 2| 8| 0| 7| 3| 2| 5| 3| 9| 2| 8| 3| 5| 3| 7| 3|              |            |
                                           | 6| 0| 1| 0| 8| 3| 6| 5| 0| 9| 6| 1| 1| 5| 4| 6| 6| 0| 9| 0|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  +  M  +     +  +  +  +     +  +  +  M  +     +  M  +               |  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
      Leukemia Mononuclear                 |                                     X                                    |          5 |
      Pars Distalis, Adenoma               |          X  X           X                             X                  |         13 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
      C-Cell, Adenoma                      |                                                                          |          5 |
      C-Cell, Carcinoma                    |    X                                                                     |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +  +  +  +     +  +  +  +     +  +  +  +  M     +  +  +               |  52        |
      Mesothelioma Benign                  |                                                    X                     |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  51        |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                |    +  I  +  M     +  +  +  +     +  +  +  +  +     +  +  +               |  48        |
      Leukemia Mononuclear                 |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    M  M  M  M     M  M  M  M     M  M  M  M  M     M  M  M               |   1        |
                                            __________________________________________________________________________|____________|
   Testes                                  |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
      Mesothelioma Malignant               |                                                                          |          1 |
      Bilateral, Interstitial Cell, Adenoma|    X  X     X           X        X  X  X           X     X               |         35 |
      Interstitial Cell, Adenoma           |          X        X  X     X              X  X                           |         14 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
      Leukemia Mononuclear                 |             X        X              X  X     X     X                     |         11 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
      Inguinal, Leukemia Mononuclear       |                         X                                                |          1 |
      Mandibular, Leukemia Mononuclear     |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                   X                                                      |          2 |
      Pancreatic, Leukemia Mononuclear     |                                              X           X               |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
      Leukemia Mononuclear                 |                   X                 X                                    |          4 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
      Leukemia Mononuclear                 |          X  X     X  X  X           X  X  X  X     X     X               |         27 |
      Osteosarcoma, Metastatic, Uncertain  |                                                                          |            |
          Primary Site                     |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  37                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 1| 5| 5| 7| 6| 4| 6| 6| 7| 5| 4| 4| 7| 6| 7|              |            |
                             DAY ON TEST   | 5| 3| 3| 3| 2| 8| 0| 7| 3| 2| 5| 3| 9| 2| 8| 3| 5| 3| 7| 3|              |            |
                                           | 6| 0| 1| 0| 8| 3| 6| 5| 0| 9| 6| 1| 1| 5| 4| 6| 6| 0| 9| 0|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  I  +               |  47        |
      Leukemia Mononuclear                 |             X                       X                                    |          4 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
      Adenoma                              |                         X                                                |          1 |
      Fibroadenoma                         |                                                    X                     |          3 |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
      Keratoacanthoma                      |       X                 X                          X                     |          3 |
      Subcutaneous Tissue, Fibroma         |                            X                                             |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                  +                                       |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
      Astrocytoma Malignant                |                                                                          |          1 |
      Leukemia Mononuclear                 |                                              X                           |          3 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
      Carcinoma, Metastatic, Zymbal's Gland|                                                                          |          1 |
      Leukemia Mononuclear                 |             X     X  X              X  X           X                     |         14 |
      Liposarcoma                          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  52        |
      Leukemia Mononuclear                 |                   X                                                      |          1 |
      Squamous Cell Carcinoma              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                           +                              |   4        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Carcinoma                            |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
      Leukemia Mononuclear                 |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  38                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 1| 5| 5| 7| 6| 4| 6| 6| 7| 5| 4| 4| 7| 6| 7|              |            |
                             DAY ON TEST   | 5| 3| 3| 3| 2| 8| 0| 7| 3| 2| 5| 3| 9| 2| 8| 3| 5| 3| 7| 3|              |            |
                                           | 6| 0| 1| 0| 8| 3| 6| 5| 0| 9| 6| 1| 1| 5| 4| 6| 6| 0| 9| 0|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     A      |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |     L      |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Renal Tubule, Adenoma                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +  +  M     +  +  +  +     M  +  +  +  +     +  +  +               |  51        |
      Leukemia Mononuclear                 |                                     X                                    |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
      Leukemia Mononuclear                 |          X  X     X  X  X           X  X  X  X     X     X               |         28 |
      Mesothelioma Benign                  |                                                    X                     |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  39                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 5| 7| 7| 1| 1| 5| 6| 7| 4| 4| 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 6| 5| 5| 2| 3| 8| 8| 6| 4| 3| 4| 5| 0| 3| 3| 5| 3| 3| 8| 1| 0| 3| 2| 3| 3|             
                                           | 4| 6| 7| 9| 2| 3| 3| 9| 4| 1| 8| 6| 6| 2| 0| 6| 0| 3| 6| 8| 6| 2| 5| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    15 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +        +  +  +  M     +  +  +     +  +  +  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Hepatocellular Carcinoma             |                                                       X                  |             
      Leukemia Mononuclear                 |       X  X                    X     X           X  X  X     X     X  X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                         X                                                |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                    X                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                    X                     |             
      Pheochromocytoma Malignant           |                                                       X                  |             
      Pheochromocytoma Benign              |          X              X                 X                 X        X   |             
      Bilateral, Pheochromocytoma Benign   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M     +  +  +        +  +  +  +     +  +  M     +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |                                        X                                X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 5| 7| 7| 1| 1| 5| 6| 7| 4| 4| 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 6| 5| 5| 2| 3| 8| 8| 6| 4| 3| 4| 5| 0| 3| 3| 5| 3| 3| 8| 1| 0| 3| 2| 3| 3|             
                                           | 4| 6| 7| 9| 2| 3| 3| 9| 4| 1| 8| 6| 6| 2| 0| 6| 0| 3| 6| 8| 6| 2| 5| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    15 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |             X                                                            |             
      C-Cell, Carcinoma                    |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                               +                                          |             
      Leukemia Mononuclear                 |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +  +  +        M  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Mesothelioma Benign                  |                                        X                                 |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                               X                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | M     M  M  M        M  M  M  M     M  M  M     M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Testes                                  | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Benign                  |                                        X                                 |             
      Bilateral, Interstitial Cell, Adenoma|       X  X           X  X  X  X        X  X     X     X  X  X  X  X  X  X|             
      Interstitial Cell, Adenoma           |             X                       X              X                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                       X     X                 X           X      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Axillary, Leukemia Mononuclear       |       X                                                                  |             
      Bronchial, Leukemia Mononuclear      |       X                                                                  |             
      Deep Cervical, Leukemia Mononuclear  |       X                                                                  |             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                       X                    X        X            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X                    X     X           X  X  X     X     X  X   |             
      Mesothelioma Benign                  |                                        X                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +  +  +        +  +  +  I     +  +  +     +  +  +  I  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Fibroadenoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Keratoacanthoma                      |                         X                          X                     |             
      Squamous Cell Carcinoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 5| 7| 7| 1| 1| 5| 6| 7| 4| 4| 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 6| 5| 5| 2| 3| 8| 8| 6| 4| 3| 4| 5| 0| 3| 3| 5| 3| 3| 8| 1| 0| 3| 2| 3| 3|             
                                           | 4| 6| 7| 9| 2| 3| 3| 9| 4| 1| 8| 6| 6| 2| 0| 6| 0| 3| 6| 8| 6| 2| 5| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    15 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                        X                                 |             
      Subcutaneous Tissue,                 |                                                                          |             
          Trichoepithelioma                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Astrocytoma Malignant                | X                                                                        |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                         X                                                |             
      Leukemia Mononuclear                 |       X                       X     X           X     X     X     X  X   |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Carcinoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Benign                  |                                        X                                 |             
      Transitional Epithelium, Papilloma   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X                    X     X           X  X  X     X     X  X   |             
      Mesothelioma Benign                  |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 7| 7| 1| 1| 5| 7| 7| 1| 7| 6| 7| 6| 1| 4| 4| 7| 7| 1| 1| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 1| 3| 3| 8| 8| 8| 2| 2| 8| 2| 1| 3| 8| 8| 5| 5| 2| 2| 8| 8| 3| 3| 3|             
                                           | 6| 6| 8| 0| 1| 3| 3| 8| 8| 5| 3| 9| 1| 0| 7| 3| 6| 6| 9| 9| 3| 3| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    15 MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    M  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Leukemia Mononuclear                 |       X                    X     X  X  X  X           X  X        X  X  X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Leukemia Mononuclear                 |                                           X                             X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +        M  +  +     +  +  +  +           +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +        M  +  +     +  +  +  +           +  +        +  +  +|             
      Leukemia Mononuclear                 |                                           X                              |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    M  +  +  +        M  +  +     +  +  +  +           +  +        +  +  +|             
      Leukemia Mononuclear                 |                                           X                              |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                         X  X              X                             X|             
      Bilateral, Pheochromocytoma Benign   |                                                          X               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    M  +  +  +        +  +  +     +  +  +  +           +  +        +  M  M|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +        M  +  +     +  +  +  +           +  +        +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 7| 7| 1| 1| 5| 7| 7| 1| 7| 6| 7| 6| 1| 4| 4| 7| 7| 1| 1| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 1| 3| 3| 8| 8| 8| 2| 2| 8| 2| 1| 3| 8| 8| 5| 5| 2| 2| 8| 8| 3| 3| 3|             
                                           | 6| 6| 8| 0| 1| 3| 3| 8| 8| 5| 3| 9| 1| 0| 7| 3| 6| 6| 9| 9| 3| 3| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    15 MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      C-Cell, Adenoma                      |                                                                   X      |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Mesothelioma Benign                  |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    M  M  M  M        M  M  M     M  M  M  M           M  M        M  M  M|             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Leukemia Mononuclear                 |                                                                         X|             
      Mesothelioma Benign                  |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma|       X  X  X        X     X     X     X  X           X  X        X  X   |             
      Interstitial Cell, Adenoma           |                         X           X                                   X|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Leukemia Mononuclear                 |                            X              X           X           X      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +        M  +  +     +  +  +  +           +  +        +  +  +|             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Bronchial, Leukemia Mononuclear      |                                                                          |             
      Deep Cervical, Leukemia Mononuclear  |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                            X                                             |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +        M  +  +     +  +  +  +           +  +        +  +  +|             
      Leukemia Mononuclear                 |                                           X           X                  |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Leukemia Mononuclear                 |       X                    X     X  X  X  X           X  X        X  X  X|             
      Mesothelioma Benign                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  I  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Leukemia Mononuclear                 |                                                       X                 X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +        +  +  +     +  +  +  +           M  +        +  +  +|             
      Fibroadenoma                         |          X                                                        X      |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +        +  +  +     +  +  +  +           M  +        +  +  +|             
      Keratoacanthoma                      |                            X                                             |             
      Squamous Cell Carcinoma              |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 7| 7| 1| 1| 5| 7| 7| 1| 7| 6| 7| 6| 1| 4| 4| 7| 7| 1| 1| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 1| 3| 3| 8| 8| 8| 2| 2| 8| 2| 1| 3| 8| 8| 5| 5| 2| 2| 8| 8| 3| 3| 3|             
                                           | 6| 6| 8| 0| 1| 3| 3| 8| 8| 5| 3| 9| 1| 0| 7| 3| 6| 6| 9| 9| 3| 3| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    15 MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Fibroma         |       X     X                                                            |             
      Subcutaneous Tissue,                 |                                                                          |             
          Trichoepithelioma                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Astrocytoma Malignant                |                                                                          |             
      Leukemia Mononuclear                 |                            X              X                              |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Leukemia Mononuclear                 |                            X        X     X           X  X        X  X  X|             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Leukemia Mononuclear                 |                                                       X                 X|             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Carcinoma                       |                                        X                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Leukemia Mononuclear                 |                                                       X                 X|             
      Mesothelioma Benign                  |                                                                          |             
      Transitional Epithelium, Papilloma   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Leukemia Mononuclear                 |       X                    X     X  X  X  X           X  X        X  X  X|             
      Mesothelioma Benign                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 7| 7| 6| 1| 5| 7| 7| 6| 4| 4| 6| 6| 6| 4| 7| 6| 5| 6|              |            |
                             DAY ON TEST   | 8| 8| 3| 2| 9| 8| 5| 3| 3| 0| 1| 2| 4| 4| 3| 5| 1| 4| 9| 6|              |            |
                                           | 3| 4| 1| 8| 6| 3| 7| 2| 1| 2| 1| 7| 7| 7| 3| 6| 8| 7| 9| 8|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |     A      |
    15 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |     L      |
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +  +  +     +  +  +  +  M  +  +  +  +     +  +  +  +               |  52        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +  +  M     +  +  +  +  +  +  +  +  +     +  +  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  52        |
      Carcinoma                            |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Leukemia Mononuclear                 |          X  X        X  X  X           X        X  X     X               |         30 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                        +                                 |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  +  +        +  +  +  +  +  +  +  +  +     +  +  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +  +        +  +  +  +  +  +  +  +  +     +  +  +  +               |  52        |
      Leukemia Mononuclear                 |                                                          X               |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +  +        +  +  +  +  +  +  +  +  +     +  +  +  +               |  52        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
      Leukemia Mononuclear                 |                            X           X           X                     |          6 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +  +  +     M  +  +  +  +  +  +  +  +     +  +  +  +               |  51        |
      Leukemia Mononuclear                 |          X                 X                                             |          5 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +  +  +     M  +  +  +  +  +  +  +  +     +  +  +  +               |  50        |
      Leukemia Mononuclear                 |                            X                                             |          3 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |       X              X                                                   |         11 |
      Bilateral, Pheochromocytoma Benign   |             X                                                            |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
      Adenoma                              |       X                                                                  |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  46                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 7| 7| 6| 1| 5| 7| 7| 6| 4| 4| 6| 6| 6| 4| 7| 6| 5| 6|              |            |
                             DAY ON TEST   | 8| 8| 3| 2| 9| 8| 5| 3| 3| 0| 1| 2| 4| 4| 3| 5| 1| 4| 9| 6|              |            |
                                           | 3| 4| 1| 8| 6| 3| 7| 2| 1| 2| 1| 7| 7| 7| 3| 6| 8| 7| 9| 8|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |     A      |
    15 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |     L      |
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  +  +  +     +  +  +  +  +  M  +  +  +     +  +  +  +               |  47        |
      Adenoma                              |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  52        |
      Leukemia Mononuclear                 |                            X                                             |          1 |
      Pars Distalis, Adenoma               |       X           X  X                                                   |          6 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
      C-Cell, Adenoma                      |                                                                          |          2 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    M  +  +  M     +  +  +  +  +  +  +  +  +     +  +  +  +               |  50        |
      Mesothelioma Benign                  |                         X                                                |          2 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +  +  +  M     +  +  +  +  +  +  +  +  +     +  +  +  +               |  52        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                |    +  +  +  M     +  +  +  +  +  +  +  +  +     +  +  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    M  M  M  M     M  M  M  M  M  M  M  M  M     M  M  M  M               |            |
                                            __________________________________________________________________________|____________|
   Testes                                  |    M  +  +  M     +  +  +  +  +  +  +  +  +     +  +  +  +               |  51        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Benign                  |                                        X                                 |          2 |
      Bilateral, Interstitial Cell, Adenoma|       X  X           X  X           X  X        X  X  X  X               |         38 |
      Interstitial Cell, Adenoma           |                            X     X        X                              |          9 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +  +  +     M  +  +  +  +  +  +  +  +     +  +  +  +               |  52        |
      Leukemia Mononuclear                 |             X           X  X                             X               |         13 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  52        |
      Axillary, Leukemia Mononuclear       |                                                                          |          1 |
      Bronchial, Leukemia Mononuclear      |                                                                          |          1 |
      Deep Cervical, Leukemia Mononuclear  |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          1 |
      Renal, Leukemia Mononuclear          |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  52        |
      Leukemia Mononuclear                 |                      X     X           X           X     X               |         11 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
      Leukemia Mononuclear                 |          X  X        X  X  X           X           X     X               |         29 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  47                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 7| 7| 6| 1| 5| 7| 7| 6| 4| 4| 6| 6| 6| 4| 7| 6| 5| 6|              |            |
                             DAY ON TEST   | 8| 8| 3| 2| 9| 8| 5| 3| 3| 0| 1| 2| 4| 4| 3| 5| 1| 4| 9| 6|              |            |
                                           | 3| 4| 1| 8| 6| 3| 7| 2| 1| 2| 1| 7| 7| 7| 3| 6| 8| 7| 9| 8|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |     A      |
    15 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |     L      |
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mesothelioma Benign                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +  +  +     +  I  +  +  +  +  I  +  +     +  +  +  +               |  48        |
      Leukemia Mononuclear                 |                                                          X               |          4 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  52        |
      Fibroadenoma                         |                                           X                              |          3 |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +  +  +     +  +  +  +  M  +  +  +  +     +  +  +  +               |  51        |
      Keratoacanthoma                      |                                                                          |          3 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          3 |
      Subcutaneous Tissue,                 |                                                                          |            |
          Trichoepithelioma                |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +  +  +     M  +  +  +  +  +  +  +  +     +  +  +  +               |  52        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
      Astrocytoma Malignant                |                                                                          |          1 |
      Leukemia Mononuclear                 |             X              X                       X     X               |          6 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          1 |
      Leukemia Mononuclear                 |          X  X        X  X  X                       X     X               |         23 |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
      Leukemia Mononuclear                 |                            X                                             |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                        +                                 |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
      Leukemia Mononuclear                 |                            X                       X     X               |          6 |
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Carcinoma                       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  48                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 7| 7| 6| 1| 5| 7| 7| 6| 4| 4| 6| 6| 6| 4| 7| 6| 5| 6|              |            |
                             DAY ON TEST   | 8| 8| 3| 2| 9| 8| 5| 3| 3| 0| 1| 2| 4| 4| 3| 5| 1| 4| 9| 6|              |            |
                                           | 3| 4| 1| 8| 6| 3| 7| 2| 1| 2| 1| 7| 7| 7| 3| 6| 8| 7| 9| 8|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |     A      |
    15 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |     L      |
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +  +  M     +  +  +  +  +  +  +  +  +     +  +  +  +               |  52        |
      Leukemia Mononuclear                 |                                                    X                     |          3 |
      Mesothelioma Benign                  |                         X                                                |          2 |
      Transitional Epithelium, Papilloma   |       X                                                                  |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
      Leukemia Mononuclear                 |          X  X        X  X  X           X        X  X     X               |         30 |
      Mesothelioma Benign                  |                         X              X                                 |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  49                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 5| 6| 1| 1| 4| 5| 6| 7| 1| 4| 4| 4| 6| 1| 1| 1| 6| 6| 5| 3| 7| 7| 6|             
                             DAY ON TEST   | 5| 5| 6| 2| 8| 8| 7| 2| 3| 3| 8| 5| 5| 8| 4| 8| 8| 8| 5| 9| 5| 5| 2| 1| 3|             
                                           | 6| 6| 4| 4| 3| 3| 7| 2| 2| 2| 3| 6| 6| 6| 2| 3| 3| 3| 7| 0| 6| 1| 9| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    30 MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +  +        +  +  +  +           +  +           M  +  +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                             X  X        X  X  X|             
      Neoplastic Nodule                    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Mesothelioma Benign                  |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Serosa, Leukemia Mononuclear         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                             X           X     X|             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                                |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 5| 6| 1| 1| 4| 5| 6| 7| 1| 4| 4| 4| 6| 1| 1| 1| 6| 6| 5| 3| 7| 7| 6|             
                             DAY ON TEST   | 5| 5| 6| 2| 8| 8| 7| 2| 3| 3| 8| 5| 5| 8| 4| 8| 8| 8| 5| 9| 5| 5| 2| 1| 3|             
                                           | 6| 6| 4| 4| 3| 3| 7| 2| 2| 2| 3| 6| 6| 6| 2| 3| 3| 3| 7| 0| 6| 1| 9| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    30 MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma Malignant           |                                                          X               |             
      Pheochromocytoma Benign              |                            X                                      X      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +  M        +  +  +  M           +  +           +  +  M  +  M  I  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
      Pars Distalis, Adenoma               |                            X                                             |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                                                          |             
      Follicle, Adenoma                    |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Benign                  |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |       +  M        M  +  M  M           M  M           M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Testes                                  |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Mesothelioma Benign                  |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma|       X           X  X     X              X           X  X  X     X  X  X|             
      Interstitial Cell, Adenoma           |          X              X              X                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +  +        +  +  +  +           +  +           +  +  +  +  M  +  +|             
      Leukemia Mononuclear                 |                         X                             X                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                                                          |             
      Mandibular, Leukemia Mononuclear     |                         X                                                |             
      Mediastinal, Leukemia Mononuclear    |                         X                                            X   |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                                         X      |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                             X  X        X  X  X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 5| 6| 1| 1| 4| 5| 6| 7| 1| 4| 4| 4| 6| 1| 1| 1| 6| 6| 5| 3| 7| 7| 6|             
                             DAY ON TEST   | 5| 5| 6| 2| 8| 8| 7| 2| 3| 3| 8| 5| 5| 8| 4| 8| 8| 8| 5| 9| 5| 5| 2| 1| 3|             
                                           | 6| 6| 4| 4| 3| 3| 7| 2| 2| 2| 3| 6| 6| 6| 2| 3| 3| 3| 7| 0| 6| 1| 9| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    30 MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                             X  X        X  X   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Fibroadenoma                         |                                                                          |             
      Fibroadenoma, Multiple               |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Carcinoma              |                                        X                                 |             
      Face, Basal Cell Carcinoma           |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +        +  +  +  +           +  +           +  +  +  +  M  +  +|             
      Osteosarcoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                             X                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Leukemia Mononuclear                 |                         X                             X              X  X|             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +                                 |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
      Papilloma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 5| 6| 1| 1| 4| 5| 6| 7| 1| 4| 4| 4| 6| 1| 1| 1| 6| 6| 5| 3| 7| 7| 6|             
                             DAY ON TEST   | 5| 5| 6| 2| 8| 8| 7| 2| 3| 3| 8| 5| 5| 8| 4| 8| 8| 8| 5| 9| 5| 5| 2| 1| 3|             
                                           | 6| 6| 4| 4| 3| 3| 7| 2| 2| 2| 3| 6| 6| 6| 2| 3| 3| 3| 7| 0| 6| 1| 9| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    30 MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                         X                             X  X        X  X  X|             
      Mesothelioma Benign                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 5| 6| 7| 6| 3| 4| 6| 5| 7| 5| 7| 6| 6| 7| 1| 3| 4| 7| 7| 1| 4| 4| 6| 7|             
                             DAY ON TEST   | 8| 2| 9| 2| 3| 3| 5| 5| 7| 3| 1| 3| 6| 8| 3| 8| 6| 5| 3| 1| 8| 1| 5| 7| 3|             
                                           | 3| 8| 8| 9| 8| 9| 6| 3| 7| 0| 9| 1| 9| 2| 0| 3| 6| 7| 2| 8| 3| 7| 6| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    30 MG/KG                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +  +     +  +  +  +  +  +  +  +     I  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     A     +  +|             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     A     +  +|             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |          X  X        X  X  X  X     X  X              X              X   |             
      Neoplastic Nodule                    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Mesothelioma Benign                  |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Serosa, Leukemia Mononuclear         |          X                                            X                  |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |          X                                            X                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |          X                                            X                  |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +  +  +  +  M     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |          X  X        X  X                                                |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |          X  X        X                                X                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 5| 6| 7| 6| 3| 4| 6| 5| 7| 5| 7| 6| 6| 7| 1| 3| 4| 7| 7| 1| 4| 4| 6| 7|             
                             DAY ON TEST   | 8| 2| 9| 2| 3| 3| 5| 5| 7| 3| 1| 3| 6| 8| 3| 8| 6| 5| 3| 1| 8| 1| 5| 7| 3|             
                                           | 3| 8| 8| 9| 8| 9| 6| 3| 7| 0| 9| 1| 9| 2| 0| 3| 6| 7| 2| 8| 3| 7| 6| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    30 MG/KG                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |                         X  X     X                                      X|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Adenoma                              |       X                                                                  |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +  +  +     +  M  +  +  +  +  +  M     +  +  M  +     M     M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |             X           X                                                |             
      Pars Distalis, Adenoma               |       X                             X     X                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      C-Cell, Adenoma                      |                      X                                                   |             
      Follicle, Adenoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +  +  +     +  M  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
      Mesothelioma Benign                  |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |                         +                                                |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  M  +  +     +     +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    M  M  M  M  M     M  M  M  M  M  M  M  M     M  M  M  M     M     M  M|             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +  +  +  +     +  M  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Mesothelioma Benign                  |                                                                          |             
      Bilateral, Interstitial Cell, Adenoma|    X  X  X  X        X           X  X  X  X           X  X           X  X|             
      Interstitial Cell, Adenoma           |                            X  X                    X                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |          X           X        X                       X                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Axillary, Leukemia Mononuclear       |          X                                                               |             
      Iliac, Leukemia Mononuclear          |          X                                                               |             
      Mandibular, Leukemia Mononuclear     |          X                                                               |             
      Mediastinal, Leukemia Mononuclear    |          X                    X                                          |             
      Pancreatic, Leukemia Mononuclear     |                      X                                                   |             
      Renal, Leukemia Mononuclear          |          X                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |          X  X        X  X  X  X     X  X              X              X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 5| 6| 7| 6| 3| 4| 6| 5| 7| 5| 7| 6| 6| 7| 1| 3| 4| 7| 7| 1| 4| 4| 6| 7|             
                             DAY ON TEST   | 8| 2| 9| 2| 3| 3| 5| 5| 7| 3| 1| 3| 6| 8| 3| 8| 6| 5| 3| 1| 8| 1| 5| 7| 3|             
                                           | 3| 8| 8| 9| 8| 9| 6| 3| 7| 0| 9| 1| 9| 2| 0| 3| 6| 7| 2| 8| 3| 7| 6| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    30 MG/KG                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  I     +     +  +|             
      Leukemia Mononuclear                 |          X              X           X                                    |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Fibroadenoma                         |                                        X  X           X                  |             
      Fibroadenoma, Multiple               |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
      Face, Basal Cell Carcinoma           |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Osteosarcoma                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |                      X  X                                                |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Leukemia Mononuclear                 |          X  X        X  X     X                       X                  |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +                                       |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Carcinoma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |          X                                                               |             
      Osteosarcoma, Metastatic, Bone       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Papilloma                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 5| 6| 7| 6| 3| 4| 6| 5| 7| 5| 7| 6| 6| 7| 1| 3| 4| 7| 7| 1| 4| 4| 6| 7|             
                             DAY ON TEST   | 8| 2| 9| 2| 3| 3| 5| 5| 7| 3| 1| 3| 6| 8| 3| 8| 6| 5| 3| 1| 8| 1| 5| 7| 3|             
                                           | 3| 8| 8| 9| 8| 9| 6| 3| 7| 0| 9| 1| 9| 2| 0| 3| 6| 7| 2| 8| 3| 7| 6| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    30 MG/KG                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Leukemia Mononuclear                 |          X  X        X  X  X  X     X  X              X              X   |             
      Mesothelioma Benign                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 3| 4| 5| 7| 7| 7| 1| 4| 5| 7| 7| 3| 3| 5| 5| 7|              |            |
                             DAY ON TEST   | 9| 3| 2| 6| 4| 5| 6| 3| 3| 3| 8| 5| 3| 3| 3| 3| 5| 1| 3| 2|              |            |
                                           | 2| 2| 9| 6| 4| 6| 4| 0| 2| 1| 3| 0| 5| 1| 0| 6| 9| 3| 2| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |     A      |
    30 MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 | X                                                                        |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  51        |
      Carcinoma                            |                                                    X                     |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  52        |
      Sarcoma                              |                                        X                                 |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 | X                 X  X     X                                             |         20 |
      Neoplastic Nodule                    |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                  +     +                                 |   2        |
      Mesothelioma Benign                  |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +     +  +  +  +     I  +  +  +  +  +  +  +  +               |  52        |
      Leukemia Mononuclear                 | X                                                                        |          3 |
      Osteosarcoma, Metastatic, Bone       |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 | X                                                                        |          2 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Serosa, Leukemia Mononuclear         |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 | X                                                                        |          3 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                   +                             +                        |   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 | X                                                                        |          9 |
      Osteosarcoma, Metastatic, Bone       |                                     X                                    |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  58                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 3| 4| 5| 7| 7| 7| 1| 4| 5| 7| 7| 3| 3| 5| 5| 7|              |            |
                             DAY ON TEST   | 9| 3| 2| 6| 4| 5| 6| 3| 3| 3| 8| 5| 3| 3| 3| 3| 5| 1| 3| 2|              |            |
                                           | 2| 2| 9| 6| 4| 6| 4| 0| 2| 1| 3| 0| 5| 1| 0| 6| 9| 3| 2| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |     A      |
    30 MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Osteosarcoma, Metastatic, Bone       |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 |                                                                          |          4 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |       X                                   X                              |          8 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +     +  +  +  +     I  +  +  +  +  +  +  +  +               |  52        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  M  +     +  +  +  +     +  M  +  +  +  M  M  +  +               |  37        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Pars Distalis, Adenoma               |                                                    X                     |          5 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      C-Cell, Adenoma                      |                                                                          |          1 |
      Follicle, Adenoma                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  52        |
      Leukemia Mononuclear                 | X                                                                        |          2 |
      Mesothelioma Benign                  |                                  X                                       |          1 |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  52        |
      Leukemia Mononuclear                 | X                                                                        |          2 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 | X                                                                        |          2 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | M  M  M  M  M     M  M  M  M     M  +  M  M  M  M  M  M  M               |   3        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  52        |
      Mesothelioma Benign                  |                                  X                                       |          1 |
      Bilateral, Interstitial Cell, Adenoma| X  X  X  X        X  X  X  X     X  X  X  X        X  X  X               |         39 |
      Interstitial Cell, Adenoma           |                                                                          |          6 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  52        |
      Leukemia Mononuclear                 | X                    X                                                   |          8 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  59                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 3| 4| 5| 7| 7| 7| 1| 4| 5| 7| 7| 3| 3| 5| 5| 7|              |            |
                             DAY ON TEST   | 9| 3| 2| 6| 4| 5| 6| 3| 3| 3| 8| 5| 3| 3| 3| 3| 5| 1| 3| 2|              |            |
                                           | 2| 2| 9| 6| 4| 6| 4| 0| 2| 1| 3| 0| 5| 1| 0| 6| 9| 3| 2| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |     A      |
    30 MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Axillary, Leukemia Mononuclear       |                                                                          |          1 |
      Iliac, Leukemia Mononuclear          |                                                                          |          1 |
      Mandibular, Leukemia Mononuclear     | X                                                                        |          3 |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          4 |
      Pancreatic, Leukemia Mononuclear     |                      X                                                   |          2 |
      Renal, Leukemia Mononuclear          | X                                                                        |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 | X                    X                                                   |          5 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 | X                 X  X     X                                             |         20 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +     I  +  +  +     +  +  +  +  +  I  +  +  +               |  50        |
      Leukemia Mononuclear                 | X                                                                        |          9 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Fibroadenoma                         |                                                                          |          3 |
      Fibroadenoma, Multiple               |    X                                                                     |          1 |
      Leukemia Mononuclear                 | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 | X                                                                        |          1 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Face, Basal Cell Carcinoma           |                      X                                                   |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  52        |
      Osteosarcoma                         |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                  +                                       |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 | X                    X                                                   |          6 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Alveolar/Bronchiolar Carcinoma       |                                        X                                 |          1 |
      Leukemia Mononuclear                 | X                 X                                                      |         12 |
      Osteosarcoma, Metastatic, Bone       |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  60                                                               
NTP Experiment-Test: 05705-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/10/97  
Route: GAVAGE                                                                                                     Time: 10:11:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 3| 4| 5| 7| 7| 7| 1| 4| 5| 7| 7| 3| 3| 5| 5| 7|              |            |
                             DAY ON TEST   | 9| 3| 2| 6| 4| 5| 6| 3| 3| 3| 8| 5| 3| 3| 3| 3| 5| 1| 3| 2|              |            |
                                           | 2| 2| 9| 6| 4| 6| 4| 0| 2| 1| 3| 0| 5| 1| 0| 6| 9| 3| 2| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |     A      |
    30 MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |     L      |
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 | X                                                                        |          2 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                           +                              |   3        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                    +                     |   1        |
      Carcinoma                            |                                                    X                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 | X                    X     X                                             |          5 |
      Osteosarcoma, Metastatic, Bone       |                                     X                                    |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Papilloma                            |                            X                                             |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Leukemia Mononuclear                 | X                 X  X     X                                             |         20 |
      Mesothelioma Benign                  |                                  X                                       |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  61                                                               
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                                  ----------              END OF REPORT             ----------                                      
                                  ------------------------------------------------------------