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P05 - Incidence Rates of Neoplasms by Anatomic Site (systemic lesions abridged) (Mice)

NTP Experiment-Test: 60946-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03

Route: GAVAGE                                                                                                     Time: 08:01:07



                                                           FINAL/MICE









       Facility:  Battelle Columbus Laboratory



       Chemical CAS #:  140-67-0



       Lock Date:  05/28/02



       Cage Range:  All



       Reasons For Removal:    All



       Removal Date Range:     All



       Treatment Groups:       Include All





































































a  Number of animals examined microscopically at site and number of animals with lesion



                                                              Page   1





NTP Experiment-Test: 60946-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03  

Route: GAVAGE                                                                                                     Time: 08:01:07  

____________________________________________________________________________________________________________________________________

                                                                                                                                    

         B6C3F1 MICE FEMALE                        0 MG/KG      37.5         75           150          300          600             

                                                                MG/KG        MG/KG        MG/KG        MG/KG        MG/KG           

____________________________________________________________________________________________________________________________________

                                                                                                                                    

DISPOSITION SUMMARY                                                                                                                 

                                                                                                                                    

  Animals Initially in Study                          10           10           10           10           10           10           

  Early Deaths                                                                                                                      

    Natural Death                                                                                                       8           

    Moribund Sacrifice                                                                                                  2           

  Survivors                                                                                                                         

    Terminal Sacrifice                                10           10           10           10           10                        

                                                                                                                                    

  Animals Examined Microscopically                    10           10           10           10           10           10           

                                                                                                                                    

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 ALIMENTARY SYSTEM                                                                                                                  

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 CARDIOVASCULAR SYSTEM                                                                                                              

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 ENDOCRINE SYSTEM                                                                                                                   

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 GENERAL BODY SYSTEM                                                                                                                

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 GENITAL SYSTEM                                                                                                                     

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 HEMATOPOIETIC SYSTEM                                                                                                               

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page   2                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03  

Route: GAVAGE                                                                                                     Time: 08:01:07  

____________________________________________________________________________________________________________________________________

                                                                                                                                    

         B6C3F1 MICE FEMALE                        0 MG/KG      37.5         75           150          300          600             

                                                                MG/KG        MG/KG        MG/KG        MG/KG        MG/KG           

____________________________________________________________________________________________________________________________________

                                                                                                                                    

                                                                                                                                    

 INTEGUMENTARY SYSTEM                                                                                                               

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 MUSCULOSKELETAL SYSTEM                                                                                                             

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 NERVOUS SYSTEM                                                                                                                     

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 RESPIRATORY SYSTEM                                                                                                                 

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 SPECIAL SENSES SYSTEM                                                                                                              

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 URINARY SYSTEM                                                                                                                     

                                                                                                                                    

   None                                                                                                                             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page   3                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03  

Route: GAVAGE                                                                                                     Time: 08:01:07  

____________________________________________________________________________________________________________________________________

                                                                                                                                    

         B6C3F1 MICE MALE                          0 MG/KG      37.5         75           150          300          600             

                                                                MG/KG        MG/KG        MG/KG        MG/KG        MG/KG           

____________________________________________________________________________________________________________________________________

                                                                                                                                    

DISPOSITION SUMMARY                                                                                                                 

                                                                                                                                    

  Animals Initially in Study                          10           10           10           10           10           10           

  Early Deaths                                                                                                                      

    Moribund Sacrifice                                                                                                  1           

  Survivors                                                                                                                         

    Terminal Sacrifice                                10           10           10           10           10            9           

                                                                                                                                    

  Animals Examined Microscopically                    10           10           10           10           10           10           

                                                                                                                                    

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 ALIMENTARY SYSTEM                                                                                                                  

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 CARDIOVASCULAR SYSTEM                                                                                                              

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 ENDOCRINE SYSTEM                                                                                                                   

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 GENERAL BODY SYSTEM                                                                                                                

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 GENITAL SYSTEM                                                                                                                     

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 HEMATOPOIETIC SYSTEM                                                                                                               

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page   4                                                               

                                                                                                                                   

NTP Experiment-Test: 60946-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05

Study Type: SUBCHRON 90-DAY                                     ESTRAGOLE                                         Date: 10/08/03  

Route: GAVAGE                                                                                                     Time: 08:01:07  

____________________________________________________________________________________________________________________________________

                                                                                                                                    

         B6C3F1 MICE MALE                          0 MG/KG      37.5         75           150          300          600             

                                                                MG/KG        MG/KG        MG/KG        MG/KG        MG/KG           

____________________________________________________________________________________________________________________________________

                                                                                                                                    

                                                                                                                                    

 INTEGUMENTARY SYSTEM                                                                                                               

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 MUSCULOSKELETAL SYSTEM                                                                                                             

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 NERVOUS SYSTEM                                                                                                                     

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 RESPIRATORY SYSTEM                                                                                                                 

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 SPECIAL SENSES SYSTEM                                                                                                              

                                                                                                                                    

   None                                                                                                                             

____________________________________________________________________________________________________________________________________

                                                                                                                                    

 URINARY SYSTEM                                                                                                                     

                                                                                                                                    

   None                                                                                                                             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page   5                                                               

                                                                                                                                   

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