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TDMS Study 99035-01 Pathology Tables

NTP  EXP/TEST: 99035-01                    TRANSGENIC MODEL EVALUATION II (GLYCIDOL)                              PAGE: 1
TEST TYPE: 26-39 WEEKS                          INITIAL AND CURRENT BODY WEIGHT                                   DATE: 03/31/04
ROUTE: GAVAGE                                                                                                     TIME: 13:02:16

                                                         EIS REPORT 03
                                                            FINAL #1


       FACILITY:  Battelle Columbus Laboratory

       NTP C#:  C99035

       CONTRACT NUMBER:  N01-ES-65406

       CAS NUMBER:  556-52-5

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL

NTP  EXP/TEST: 99035-01                    TRANSGENIC MODEL EVALUATION II (GLYCIDOL)                              PAGE: 2
TEST TYPE: 26-39 WEEKS                          INITIAL AND CURRENT BODY WEIGHT                                   DATE: 03/31/04
ROUTE: GAVAGE                                               EISRPT03                                              TIME: 13:02:16
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 SPECIES-STRAIN: TG:P16-INK4A-MICE          SEX: FEMALE      WEEK ON DOSE: 41     FIRST DOSE: 02/03/00
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                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 0 MG/KG            15     21.3    1.1        13     41.8    7.3                     13     20.4    6.7

 25 MG/KG           15     21.5    1.0        14     39.4    4.6        94.2         14     18.1    4.6

 50 MG/KG           15     21.4    0.8        12     37.4    5.0        89.4         12     15.9    4.6

 100     MG/KG      15     21.5    1.0        14     34.5    4.2        82.5         14     13.0    3.8

 200     MG/KG      15     21.6    0.9         9     31.1    3.4        74.4          9      9.2    3.4




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 SPECIES-STRAIN: TG:P16-INK4A-MICE          SEX: MALE        WEEK ON DOSE: 41     FIRST DOSE: 02/03/00
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                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 0 MG/KG            15     27.4    1.4        13     48.7    2.6                     13     21.5    2.1

 25 MG/KG           15     27.0    1.3        14     47.9    4.1        98.3         14     20.9    3.3

 50 MG/KG           15     27.3    1.6        13     48.3    1.8        99.1         13     21.2    1.5

 100     MG/KG      15     27.1    1.3        14     47.5    3.4        97.5         14     20.3    3.0

 200     MG/KG      15     27.5    1.8         7     39.8    5.8        81.7          7     12.5    5.3

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