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https://ntp.niehs.nih.gov/go/17435

TDMS Study 99036-01 Pathology Tables

NTP  EXP/TEST: 99036-01                 TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)                          PAGE: 1
TEST TYPE: SUBCHRON 26-WEEK                     INITIAL AND CURRENT BODY WEIGHT                                   DATE: 04/21/04
ROUTE: DOSED FEED                                                                                                 TIME: 08:28:43

                                                         EIS REPORT 03


       FACILITY:  Battelle Columbus Laboratory

       NTP C#:  C99036

       CONTRACT NUMBER:  N01-ES-65406

       CAS NUMBER:  77-09-08

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL

NTP  EXP/TEST: 99036-01                 TRANSGENIC MODEL EVALUATION II (PHENOLPHTHALEIN)                          PAGE: 2
TEST TYPE: SUBCHRON 26-WEEK                     INITIAL AND CURRENT BODY WEIGHT                                   DATE: 04/21/04
ROUTE: DOSED FEED                                           EISRPT03                                              TIME: 08:28:43
----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: TG:P16-INK4A-MICE          SEX: FEMALE      WEEK ON DOSE: 27     FIRST DOSE: 12/08/99
----------------------------------------------------------------------------------------------------------------------------------
                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 0 PPM              15     16.4    0.6        15     25.3    1.8                     15      8.9    1.8

 200 PPM            15     16.4    1.1        13     25.5    1.0       100.7         13      9.1    0.7

 375 PPM            15     16.4    0.8        14     26.5    2.7       104.7         14     10.2    2.3

 750 PPM            15     16.5    0.8        15     25.1    1.5        99.2         15      8.6    1.7

 3000 PPM           15     16.5    1.0        14     25.1    1.2        99.2         14      8.7    1.4

 12,000  PPM        15     16.5    1.0        15     25.4    1.1       100.3         15      8.8    1.1




----------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: TG:P16-INK4A-MICE          SEX: MALE        WEEK ON DOSE: 27     FIRST DOSE: 12/08/99
----------------------------------------------------------------------------------------------------------------------------------
                     -----INITIAL-----         ------------CURRENT-------------       -----CHANGE------
TREATMENT            N   MEAN(G)    SD         N   MEAN(G)    SD    % REL CNTRL       N   MEAN(G)    SD

 0 PPM              15     20.1    0.7        13     34.3    4.0                     13     14.0    4.1

 200 PPM            15     20.0    0.8        15     36.0    3.7       104.9         15     16.0    3.4

 375 PPM            15     19.9    0.8        15     35.4    3.3       103.2         15     15.5    2.8

 750 PPM            15     20.0    0.9        13     35.9    2.4       104.6         13     15.7    2.1

 3000 PPM           15     19.9    0.9        15     33.6    3.1        97.9         15     13.8    2.8

 12,000  PPM        15     19.6    0.7        14     30.3    2.0        88.3         14     10.7    2.0

                                               -----------------------------------
                                               ---------- END-OF-REPORT ----------
                                               -----------------------------------