National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/17799

TDMS Study 92012-03 Pathology Tables

NTP Experiment-Test: 92012-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                 2-METHYLIMIDAZOLE                                     Date: 08/06/96
Route: DOSED FEED                                                                                                 Time: 20:23:41

                                                       90-DAY SUBCHRONIC




       Facility:  Microbiological Associates

       Chemical CAS #:  693-98-1

       Lock Date:  08/31/94

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 92012-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                 2-METHYLIMIDAZOLE                                     Date: 08/06/96  
Route: DOSED FEED                                                                                                 Time: 20:23:41  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   UNTREAT      625          1250         2500         5000         10000           
                                                   CONTROL      PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Accidently Killed                                  3                                      3            2            5           
    Terminal Sacrifice                                 7           10           10            7            8            5           

  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (10)         (1)                       (1)          (1)          (10)         
      Hepatodiaphragmatic Nodule                                    1 (100%)                  1 (100%)                  1 (10%)     
      Inflammation, Focal                              2 (20%)                                1 (100%)     1 (100%)     4 (40%)     
   Mesentery                                          (1)          (1)          (1)                                                 
      Fat, Necrosis                                    1 (100%)     1 (100%)     1 (100%)                                           
   Pancreas                                           (10)                                                (1)          (10)         
      Acinus, Degeneration, Focal                      2 (20%)                                             1 (100%)     1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)                                                (1)          (10)         
      Cardiomyopathy                                   1 (10%)                                             1 (100%)     1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (10)         (1)          (1)                       (10)         (10)         
      Necrosis, Acute                                               1 (100%)     1 (100%)                               2 (20%)     
   Thyroid Gland                                      (10)         (9)          (10)         (10)         (10)         (10)         
      Follicular Cell, Hyperplasia, Diffuse                                                  10 (100%)    10 (100%)    10 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (10)                                   (1)          (1)          (10)         
      Inflammation, Focal                              1 (10%)                                1 (100%)     1 (100%)     3 (30%)     
   Ovary                                              (10)         (2)          (1)          (1)          (1)          (10)         
      Cyst                                                          1 (50%)      1 (100%)     1 (100%)     1 (100%)     1 (10%)     
      Bilateral, Cyst                                               1 (50%)                                                         

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 92012-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                 2-METHYLIMIDAZOLE                                     Date: 08/06/96  
Route: DOSED FEED                                                                                                 Time: 20:23:41  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   UNTREAT      625          1250         2500         5000         10000           
                                                   CONTROL      PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
   Uterus                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Hydrometra                                                                 1 (10%)                                            
      Bilateral, Hydrometra                                         2 (20%)      1 (10%)      2 (20%)      1 (10%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (10)                                                             (10)         
      Hyperplasia                                                                                                       1 (10%)     
      Infiltration Cellular, Histiocyte                1 (10%)                                                                      
   Lymph Node, Mandibular                             (10)                                                             (10)         
      Hemorrhage                                       2 (20%)                                                          1 (10%)     
      Infiltration Cellular, Plasma Cell                                                                                1 (10%)     
   Lymph Node, Mesenteric                             (10)         (10)         (10)         (10)         (10)         (10)         
      Infiltration Cellular, Histiocyte                8 (80%)      4 (40%)      9 (90%)      5 (50%)     10 (100%)    10 (100%)    
   Spleen                                             (10)                                                             (10)         
      Lymphoid Follicle, Necrosis                      3 (30%)                                                          1 (10%)     
   Thymus                                             (10)                                   (1)                       (10)         
      Hemorrhage                                                                              1 (100%)                  1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)                                                (1)          (10)         
      Inflammation, Focal                              1 (10%)                                             1 (100%)     4 (40%)     
   Nose                                               (10)                                                             (10)         
      Respiratory Epithelium, Inflammation,                                                                                         

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 92012-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                 2-METHYLIMIDAZOLE                                     Date: 08/06/96  
Route: DOSED FEED                                                                                                 Time: 20:23:41  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   UNTREAT      625          1250         2500         5000         10000           
                                                   CONTROL      PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
          Suppurative                                  2 (20%)                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 92012-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                 2-METHYLIMIDAZOLE                                     Date: 08/06/96  
Route: DOSED FEED                                                                                                 Time: 20:23:41  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREAT      625          1250         2500         5000         10000           
                                                   CONTROL      PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10           10           

  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Ileum                             (10)                                                             (10)         
      Inflammation, Chronic, Focal                     1 (10%)                                                                      
   Liver                                              (10)                      (1)                                    (10)         
      Hepatodiaphragmatic Nodule                                                 1 (100%)                                           
      Inflammation, Focal                              1 (10%)                                                          1 (10%)     
   Pancreas                                           (10)                                                             (10)         
      Acinus, Degeneration, Focal                      1 (10%)                                                          1 (10%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Cardiomyopathy                                   7 (70%)      7 (70%)      8 (80%)      8 (80%)      4 (40%)      4 (40%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Thyroid Gland                                      (10)         (10)         (10)         (10)         (10)         (10)         
      Follicular Cell, Cyst                                                                                             1 (10%)     
      Follicular Cell, Hyperplasia, Diffuse            2 (20%)                   8 (80%)     10 (100%)    10 (100%)    10 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (10)                                                             (10)         
      Inflammation, Focal                              1 (10%)                                                          1 (10%)     
   Testes                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Degeneration                                     2 (20%)      2 (20%)      1 (10%)      2 (20%)      2 (20%)      9 (90%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 92012-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                 2-METHYLIMIDAZOLE                                     Date: 08/06/96  
Route: DOSED FEED                                                                                                 Time: 20:23:41  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     UNTREAT      625          1250         2500         5000         10000           
                                                   CONTROL      PPM          PPM          PPM          PPM          PPM             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node, Mandibular                             (9)                                                              (9)          
      Hemorrhage                                       1 (11%)                                                                      
   Lymph Node, Mesenteric                             (10)         (10)         (10)         (10)         (10)         (10)         
      Hemorrhage                                                                                           1 (10%)                  
      Infiltration Cellular, Histiocyte                1 (10%)      1 (10%)      4 (40%)      3 (30%)      4 (40%)      4 (40%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (10)                                                             (10)         
      Inflammation, Focal                              3 (30%)                                                          1 (10%)     
      Alveolus, Infiltration Cellular, Histiocyte      1 (10%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (10)                                                (1)          (10)         
      Nephropathy                                      6 (60%)                                                          3 (30%)     
      Renal Tubule, Dilatation, Focal                                                                                   1 (10%)     
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

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