National Toxicology Program

National Toxicology Program
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TDMS Study 96018-04 Pathology Tables

                                                                                                                                   
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: Southern Research Inst           WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                          DATE: 03/25/03  
EXPERIMENT: 96018 TEST: 04                                                                                        TIME: 11:01:46    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: DOSED WATER                                            NTP:  C96018      
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                           FINAL #1/MICE                                                            
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: SOUTHERN RESEARCH INSTITUTE                      WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)        DATE: 03/25/03    
EXPERIMENT: 96018 TEST: 04                                                                                        TIME: 11:06:27    
SPECIES: MICE, B6C3F1                                                                                                               
TEST TYPE: TWO YEAR                                 ROUTE: DOSED WATER                                            NTP:  C96018      
CONT: N01-ES-85420                                                                                                CAS: 75-27-4      
                                                                                                                                   
                                                                                                                                    
                             MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE MICE IN THE                                                   
            TWO YEAR DOSED WATER STUDY OF WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE)                                      
==========================================================================================================                          
WEEK     0 MG/L                 175 MG/L                 350 MG/L                 700 MG/L                                          
         ----------------       ----------------         ----------------         ----------------                                  
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.                               
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)                              
=========================================================================================================                           
  B        18.6       50        18.4     98.9    50      18.6    100.0    50      18.5     99.5    50                               
  1        18.6       50        18.4     98.9    50      18.6    100.0    50      18.5     99.5    50                               
  4        21.7       50        20.8     95.9    50      20.1     92.6    50      20.1     92.6    50                               
  8        26.4       50        24.2     91.7    50      24.6     93.2    50      24.4     92.4    50                               
 12        32.1       50        27.2     84.7    50      28.2     87.9    50      27.3     85.0    50                               
 16        37.9       50        31.8     83.9    50      33.3     87.9    50      31.7     83.6    50                               
 20        42.6       50        34.8     81.7    50      37.2     87.3    50      35.5     83.3    50                               
 24        45.9       50        37.8     82.4    50      38.5     83.9    50      37.3     81.3    50                               
 28        50.0       50        40.1     80.2    50      41.4     82.8    50      40.4     80.8    50                               
 32        51.8       50        43.8     84.6    49      45.4     87.6    50      43.7     84.4    50                               
 36        54.8       50        46.6     85.0    49      48.2     88.0    50      47.4     86.5    50                               
 40        58.1       50        50.6     87.1    49      52.8     90.9    50      51.3     88.3    50                               
 44        59.4       50        54.6     91.9    49      55.7     93.8    50      54.3     91.4    50                               
 48        60.2       50        57.0     94.7    48      58.4     97.0    49      56.4     93.7    50                               
 52        61.2       49        58.1     94.9    48      58.1     94.9    49      55.6     90.8    50                               
 56        62.3       49        57.3     92.0    48      58.8     94.4    49      56.3     90.4    50                               
 60        64.4       49        58.3     90.5    48      61.2     95.0    49      58.3     90.5    50                               
 64        64.7       48        60.0     92.7    48      60.5     93.5    49      59.9     92.6    49                               
 68        65.4       48        60.8     93.0    48      61.4     93.9    47      60.3     92.2    49                               
 72        66.6       48        62.2     93.4    48      62.7     94.1    46      61.4     92.2    48                               
 76        66.6       48        61.3     92.0    46      61.7     92.6    46      60.1     90.2    47                               
 80        65.1       48        59.2     90.9    45      60.1     92.3    45      59.1     90.8    46                               
 84        65.4       46        59.9     91.6    44      60.7     92.8    45      59.3     90.7    46                               
 88        66.1       44        61.2     92.6    43      60.9     92.1    43      60.9     92.1    45                               
 92        64.0       44        59.8     93.4    42      59.4     92.8    43      59.6     93.1    44                               
 96        62.2       43        56.5     90.8    39      55.8     89.7    38      57.3     92.1    43                               
100        60.4       41        54.7     90.6    37      52.4     86.8    36      56.5     93.5    40                               
104        56.9       38        53.8     94.6    36      51.8     91.0    33      55.3     97.2    39                               
TERM. SAC.            36                         36                       33                       39                               
==========================================================================================================                          
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
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