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TDMS Study 05004-04 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                               FURAN


NTP Experiment-Test: 05004-04                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/03/94
Route: GAVAGE                                                                                                     Time: 02:49:48




       Facility:  Southern Research Institute

       Chemical CAS #:  110-00-9

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05004-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               FURAN                                           Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 02:49:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      8. MG/KG     15.                                                    
                                                   CONTROL                   MG/KG                                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          16           16           35                                                  
    Natural Death                                      1            1                                                               
    Dead                                               4            8           11                                                  
    Dosing Accident                                                              1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           25            2                                                  
    Dead                                               1                                                                            
  Other                                                                          1                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)                                                
      Perforation                                                                1 (2%)                                             
   Gallbladder                                        (49)         (49)         (43)                                                
      Infarct                                                                    1 (2%)                                             
   Intestine Large, Cecum                             (49)         (49)         (46)                                                
      Edema                                                         1 (2%)                                                          
   Intestine Large, Rectum                            (49)         (49)         (48)                                                
      Inflammation, Chronic                                                      1 (2%)                                             
   Intestine Small, Duodenum                          (49)         (47)         (45)                                                
      Congestion                                                                 1 (2%)                                             
      Inflammation, Chronic                                         1 (2%)                                                          
      Mucosa, Hyperplasia, Adenomatous                                           1 (2%)                                             
      Mucosa, Ulcer                                                 1 (2%)       1 (2%)                                             
   Intestine Small, Ileum                             (48)         (47)         (44)                                                
      Lymphoid Tissue, Mineralization                  1 (2%)                                                                       
   Intestine Small, Jejunum                           (49)         (47)         (44)                                                
      Mucosa, Amyloid Deposition                                    1 (2%)                                                          
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis                                                   2 (4%)       3 (6%)                                             
      Basophilic Focus                                              1 (2%)                                                          
      Clear Cell Focus                                                           1 (2%)                                             
      Congestion                                       2 (4%)       1 (2%)                                                          
      Cyst                                                          1 (2%)       1 (2%)                                             
      Eosinophilic Focus                                            1 (2%)       1 (2%)                                             
      Granuloma                                                                  1 (2%)                                             
      Hematopoietic Cell Proliferation                11 (22%)      9 (18%)      2 (4%)                                             
      Hemorrhage                                                    1 (2%)       1 (2%)                                             
      Hyperplasia, Lymphoid                           27 (54%)     33 (66%)     42 (84%)                                            
      Hyperplasia, Multifocal                                      48 (96%)     48 (96%)                                            
      Infarct                                                       7 (14%)     11 (22%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05004-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               FURAN                                           Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 02:49:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      8. MG/KG     15.                                                    
                                                   CONTROL                   MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Infiltration Cellular, Mixed Cell                8 (16%)     23 (46%)     32 (64%)                                            
      Inflammation, Multifocal                        27 (54%)     13 (26%)                                                         
      Mineralization                                                1 (2%)       2 (4%)                                             
      Mixed Cell Focus                                 1 (2%)       5 (10%)      3 (6%)                                             
      Necrosis, Multifocal                             3 (6%)       1 (2%)       3 (6%)                                             
      Thrombosis                                                                 3 (6%)                                             
      Vacuolization Cytoplasmic                        6 (12%)     29 (58%)     36 (72%)                                            
      Bile Duct, Dilatation                                         1 (2%)      11 (22%)                                            
      Biliary Tract, Fibrosis                                      47 (94%)     50 (100%)                                           
      Biliary Tract, Granuloma                                                   1 (2%)                                             
      Biliary Tract, Hyperplasia                                   47 (94%)     50 (100%)                                           
      Biliary Tract, Inflammation, Chronic             2 (4%)      48 (96%)     50 (100%)                                           
      Hepatocyte, Cytomegaly                                       48 (96%)     50 (100%)                                           
      Hepatocyte, Degeneration                                     47 (94%)     48 (96%)                                            
      Hepatocyte, Necrosis                                         44 (88%)     47 (94%)                                            
      Kupffer Cell, Pigmentation                       5 (10%)     48 (96%)     50 (100%)                                           
      Parenchyma, Atrophy, Focal                                    1 (2%)                                                          
      Parenchyma, Atrophy, Multifocal                              47 (94%)     50 (100%)                                           
   Mesentery                                          (24)         (27)         (4)                                                 
      Edema                                            1 (4%)                                                                       
      Inflammation, Chronic                                         1 (4%)       1 (25%)                                            
      Inflammation, Suppurative                        8 (33%)      7 (26%)      3 (75%)                                            
      Fat, Necrosis                                    4 (17%)      7 (26%)      1 (25%)                                            
   Pancreas                                           (50)         (49)         (50)                                                
      Atrophy, Focal                                   1 (2%)                    2 (4%)                                             
      Fibrosis, Focal                                                            1 (2%)                                             
      Hyperplasia, Lymphoid                                         5 (10%)                                                         
      Infarct                                          1 (2%)                                                                       
      Inflammation, Chronic                                         1 (2%)       1 (2%)                                             
      Inflammation, Suppurative                        1 (2%)                                                                       
      Acinar Cell, Hyperplasia                                      1 (2%)                                                          
      Acinus, Hypoplasia                                                         1 (2%)                                             
      Artery, Inflammation, Chronic                                              2 (4%)                                             
      Duct, Cyst                                                                 2 (4%)                                             
      Duct, Dilatation                                                           1 (2%)                                             
   Salivary Glands                                    (50)         (50)         (50)                                                
      Hyperplasia, Lymphoid                            2 (4%)       4 (8%)                                                          
   Stomach, Forestomach                               (50)         (49)         (49)                                                
      Edema                                                         1 (2%)                                                          
      Erosion                                                                    1 (2%)                                             
      Hyperplasia                                      1 (2%)                    2 (4%)                                             
      Hyperplasia, Papillary                                        1 (2%)                                                          
      Hyperplasia, Squamous                                                      2 (4%)                                             
      Inflammation, Focal                             10 (20%)      7 (14%)      9 (18%)                                            
      Mineralization                                   1 (2%)                                                                       
      Ulcer                                                                      1 (2%)                                             
      Mucosa, Cyst                                                               1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05004-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               FURAN                                           Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 02:49:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      8. MG/KG     15.                                                    
                                                   CONTROL                   MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Mucosa, Erosion                                  1 (2%)       2 (4%)       1 (2%)                                             
      Mucosa, Hyperplasia, Papillary                  10 (20%)     10 (20%)      8 (16%)                                            
      Mucosa, Ulcer                                    2 (4%)                    2 (4%)                                             
   Stomach, Glandular                                 (49)         (49)         (50)                                                
      Edema                                                         1 (2%)                                                          
      Hyperplasia, Lymphoid                            1 (2%)       2 (4%)                                                          
      Inflammation, Focal                              1 (2%)                                                                       
      Mineralization                                   1 (2%)       3 (6%)                                                          
      Epithelium, Degeneration, Hyaline                2 (4%)       5 (10%)      2 (4%)                                             
      Epithelium, Metaplasia, Squamous                 2 (4%)       1 (2%)                                                          
      Epithelium, Vacuolization Cytoplasmic,                                                                                        
          Multifocal                                                1 (2%)                                                          
      Mucosa, Cyst                                    11 (22%)     12 (24%)     10 (20%)                                            
      Mucosa, Dysplasia, Focal                                                   1 (2%)                                             
      Mucosa, Erosion                                  1 (2%)       2 (4%)       2 (4%)                                             
      Mucosa, Hemorrhage                                                         2 (4%)                                             
      Mucosa, Hyperplasia                              3 (6%)       5 (10%)      3 (6%)                                             
      Mucosa, Mineralization                                        1 (2%)       2 (4%)                                             
      Mucosa, Necrosis, Focal                                                    1 (2%)                                             
      Mucosa, Necrosis, Multifocal                                               1 (2%)                                             
      Mucosa, Pigmentation                                                       1 (2%)                                             
      Serosa, Inflammation, Chronic                                 1 (2%)                                                          
   Tongue                                                          (2)          (1)                                                 
      Angiectasis                                                   1 (50%)                                                         
      Hemorrhage                                                                 1 (100%)                                           
      Necrosis                                                                   1 (100%)                                           
   Tooth                                              (2)          (1)          (3)                                                 
      Incisor, Dysplasia                               2 (100%)     1 (100%)     3 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (2)          (2)          (3)                                                 
      Abdominal, Inflammation, Chronic                                           1 (33%)                                            
      Mesenteric Artery, Inflammation, Chronic         1 (50%)      1 (50%)      2 (67%)                                            
      Pulmonary Artery, Inflammation, Chronic                       1 (50%)                                                         
      Pulmonary Artery, Mineralization                 1 (50%)                                                                      
   Heart                                              (50)         (50)         (50)                                                
      Artery, Inflammation, Chronic                                              1 (2%)                                             
      Atrium, Inflammation, Chronic                                 1 (2%)                                                          
      Atrium, Thrombosis                               1 (2%)                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05004-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               FURAN                                           Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 02:49:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      8. MG/KG     15.                                                    
                                                   CONTROL                   MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Accessory Adrenal Cortical Nodule                             2 (4%)       1 (2%)                                             
      Cyst                                             1 (2%)                                                                       
      Cytologic Alterations, Focal                                  1 (2%)                                                          
      Developmental Malformation                                    1 (2%)                                                          
      Hyperplasia, Focal                                                         1 (2%)                                             
      Vacuolization Cytoplasmic, Focal                              1 (2%)                                                          
      Extra Adrenal Tissue, Accessory Adrenal                                                                                       
          Cortical Nodule                                           2 (4%)                                                          
      Subcapsular, Hyperplasia, Focal                  4 (8%)       1 (2%)                                                          
   Adrenal Gland, Medulla                             (50)         (50)         (50)                                                
      Ectopic Tissue                                                1 (2%)                                                          
      Hyperplasia                                                                1 (2%)                                             
      Hyperplasia, Focal                               2 (4%)       1 (2%)       8 (16%)                                            
   Parathyroid Gland                                  (50)         (50)         (50)                                                
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
   Pituitary Gland                                    (49)         (47)         (46)                                                
      Pars Distalis, Angiectasis                       3 (6%)       2 (4%)       4 (9%)                                             
      Pars Distalis, Cyst                              1 (2%)       1 (2%)       2 (4%)                                             
      Pars Distalis, Focal Cellular Change                          1 (2%)                                                          
      Pars Distalis, Hyperplasia                       1 (2%)                    1 (2%)                                             
      Pars Distalis, Hyperplasia, Focal                8 (16%)      8 (17%)      5 (11%)                                            
      Pars Intermedia, Vacuolization Cytoplasmic                    1 (2%)                                                          
      Pars Nervosa, Hyperplasia, Focal                              1 (2%)                                                          
      Rathke's Cleft, Hemorrhage                                    1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (50)                                                
      Degeneration, Cystic                             4 (8%)       4 (8%)       7 (14%)                                            
      Follicle, Cyst                                                1 (2%)                                                          
      Follicular Cell, Hyperplasia                    14 (28%)     11 (22%)      8 (16%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                                               (1)                                                 
      Inflammation, Suppurative                                                  1 (100%)                                           
   Ovary                                              (49)         (49)         (50)                                                
      Angiectasis                                      2 (4%)       2 (4%)                                                          
      Cyst                                                                       1 (2%)                                             
      Ectopic Tissue                                                             1 (2%)                                             
      Fibrosis                                                                   1 (2%)                                             
      Inflammation, Chronic                                         1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05004-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               FURAN                                           Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 02:49:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      8. MG/KG     15.                                                    
                                                   CONTROL                   MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Inflammation, Suppurative                        7 (14%)     10 (20%)      3 (6%)                                             
      Mineralization                                                             1 (2%)                                             
      Pigmentation                                                               1 (2%)                                             
      Artery, Inflammation, Chronic                                              1 (2%)                                             
      Corpus Luteum, Degeneration                                   1 (2%)       1 (2%)                                             
      Corpus Luteum, Granuloma                                      1 (2%)       1 (2%)                                             
      Follicle, Cyst                                  19 (39%)     15 (31%)     21 (42%)                                            
   Oviduct                                            (4)          (4)          (1)                                                 
      Ectopic Tissue                                                             1 (100%)                                           
      Inflammation, Suppurative                        3 (75%)      2 (50%)                                                         
   Uterus                                             (50)         (50)         (50)                                                
      Angiectasis                                                   1 (2%)       3 (6%)                                             
      Hydrometra                                       8 (16%)      7 (14%)      7 (14%)                                            
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Inflammation, Suppurative                        8 (16%)      9 (18%)      5 (10%)                                            
      Thrombosis                                       1 (2%)                                                                       
      Endometrium, Hyperplasia, Cystic                48 (96%)     47 (94%)     42 (84%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
      Angiectasis                                                   1 (2%)                                                          
      Hyperplasia                                                   1 (2%)                                                          
      Hyperplasia, Neutrophil                          2 (4%)       1 (2%)                                                          
      Myelofibrosis                                                 1 (2%)                                                          
   Lymph Node                                         (50)         (50)         (50)                                                
      Iliac, Hyperplasia                               2 (4%)       1 (2%)                                                          
      Iliac, Hyperplasia, Lymphoid                     1 (2%)                                                                       
      Inguinal, Hyperplasia                                         2 (4%)                                                          
      Inguinal, Hyperplasia, Lymphoid                  3 (6%)       2 (4%)                                                          
      Lumbar, Hyperplasia, Lymphoid                                 1 (2%)                                                          
      Pancreatic, Hyperplasia, Lymphoid                             1 (2%)                                                          
      Pancreatic, Inflammation, Suppurative                         1 (2%)                                                          
      Popliteal, Hyperplasia, Lymphoid                              1 (2%)                                                          
      Renal, Hyperplasia                               5 (10%)      2 (4%)       1 (2%)                                             
      Renal, Hyperplasia, Lymphoid                     1 (2%)                                                                       
   Lymph Node, Bronchial                              (21)         (29)         (21)                                                
      Hyperplasia                                      1 (5%)       4 (14%)      1 (5%)                                             
      Hyperplasia, Lymphoid                            4 (19%)      4 (14%)                                                         
   Lymph Node, Mandibular                             (47)         (46)         (48)                                                
      Angiectasis                                                   1 (2%)                                                          
      Cyst                                             1 (2%)                                                                       
      Hyperplasia                                      1 (2%)       1 (2%)       3 (6%)                                             
      Hyperplasia, Lymphoid                            1 (2%)       4 (9%)                                                          
   Lymph Node, Mediastinal                            (41)         (45)         (43)                                                
      Angiectasis                                                                2 (5%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05004-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               FURAN                                           Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 02:49:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      8. MG/KG     15.                                                    
                                                   CONTROL                   MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia                                      7 (17%)      6 (13%)      2 (5%)                                             
      Hyperplasia, Lymphoid                            1 (2%)       6 (13%)      2 (5%)                                             
      Inflammation, Suppurative                        2 (5%)       2 (4%)       1 (2%)                                             
      Artery, Inflammation, Chronic                                              1 (2%)                                             
   Lymph Node, Mesenteric                             (49)         (49)         (49)                                                
      Angiectasis                                                   3 (6%)       1 (2%)                                             
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hyperplasia                                                   2 (4%)                                                          
      Hyperplasia, Lymphoid                            7 (14%)      5 (10%)      5 (10%)                                            
      Inflammation, Suppurative                        1 (2%)                                                                       
   Spleen                                             (50)         (50)         (50)                                                
      Hematopoietic Cell Proliferation                17 (34%)     17 (34%)     34 (68%)                                            
      Hyperplasia, Lymphoid                            8 (16%)     14 (28%)      7 (14%)                                            
   Thymus                                             (46)         (46)         (45)                                                
      Angiectasis                                                   1 (2%)                                                          
      Depletion Lymphoid                               4 (9%)       1 (2%)       1 (2%)                                             
      Hyperplasia, Lymphoid                                         2 (4%)                                                          
      Infiltration Cellular, Mixed Cell                             1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (50)         (48)                                                
      Dilatation                                      19 (39%)     17 (34%)     18 (38%)                                            
      Hyperplasia, Cystic                              1 (2%)                                                                       
      Inflammation                                     1 (2%)                                                                       
   Skin                                               (50)         (50)         (50)                                                
      Inflammation, Chronic                            5 (10%)      5 (10%)      2 (4%)                                             
      Ulcer                                            1 (2%)       1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Hemorrhage                                            2 (4%)                                             
      Subcutaneous Tissue, Hyperplasia, Lymphoid                                 1 (2%)                                             
      Subcutaneous Tissue, Infiltration Cellular,                                                                                   
           Mixed Cell                                               1 (2%)                                                          
      Subcutaneous Tissue, Inflammation, Chronic                    1 (2%)                                                          
      Subcutaneous Tissue, Inflammation,                                                                                            
          Suppurative                                               2 (4%)       1 (2%)                                             
      Subcutaneous Tissue, Fat, Necrosis                            1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Distal, Joint, Femur, Arthrosis                               1 (2%)                                                          
      Femur, Fracture                                                            1 (2%)                                             
      Trabecula, Cranium, Hyperostosis                              1 (2%)                                                          
   Skeletal Muscle                                    (3)          (2)                                                              
      Necrosis, Multifocal                             1 (33%)                                                                      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05004-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               FURAN                                           Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 02:49:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      8. MG/KG     15.                                                    
                                                   CONTROL                   MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
MUSCULOSKELETAL SYSTEM - CONT                                                                                                       
      Hindlimb, Inflammation, Suppurative                           1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Compression                                      1 (2%)       1 (2%)                                                          
      Hemorrhage, Focal                                1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Congestion                                                                 4 (8%)                                             
      Hemorrhage                                       2 (4%)                                                                       
      Hyperplasia, Lymphoid                           22 (44%)     27 (54%)     28 (56%)                                            
      Hyperplasia, Macrophage                          1 (2%)       2 (4%)       2 (4%)                                             
      Infiltration Cellular, Mixed Cell                2 (4%)       7 (14%)      2 (4%)                                             
      Inflammation, Suppurative                        1 (2%)       2 (4%)                                                          
      Alveolar Epithelium, Hyperplasia                 1 (2%)                                                                       
      Fat, Mediastinum, Necrosis                                    1 (2%)                                                          
      Mediastinum, Foreign Body                                                  1 (2%)                                             
      Mediastinum, Hemorrhage                                                    1 (2%)                                             
      Mediastinum, Hyperplasia, Lymphoid               1 (2%)       1 (2%)       2 (4%)                                             
      Mediastinum, Inflammation, Suppurative           3 (6%)       5 (10%)      1 (2%)                                             
      Pleura, Fibrosis                                                           1 (2%)                                             
      Pleura, Inflammation, Suppurative                                          1 (2%)                                             
   Nose                                               (50)         (50)         (50)                                                
      Lumen, Exudate                                  23 (46%)     18 (36%)     20 (40%)                                            
      Lumen, Foreign Body                             27 (54%)     26 (52%)     26 (52%)                                            
      Lumen, Hemorrhage                                                          1 (2%)                                             
      Lumen, Inflammation, Suppurative                                           1 (2%)                                             
      Mucosa, Cyst                                     1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation, Suppurative                               2 (4%)                                             
   Trachea                                            (50)         (50)         (50)                                                
      Artery, Peritracheal Tissue, Inflammation,                                                                                    
           Chronic                                     2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (4)          (6)          (4)                                                 
      Acinus, Dilatation                                            1 (17%)      1 (25%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05004-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               FURAN                                           Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 02:49:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      8. MG/KG     15.                                                    
                                                   CONTROL                   MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)                                                
      Atrophy                                          1 (2%)                                                                       
      Cyst                                                          1 (2%)                                                          
      Fibrosis                                         2 (4%)       4 (8%)                                                          
      Hydronephrosis                                                             1 (2%)                                             
      Infiltration Cellular, Polymorphonuclear                                   1 (2%)                                             
      Infiltration Cellular, Mixed Cell                1 (2%)       3 (6%)                                                          
      Metaplasia, Osseous                              1 (2%)       2 (4%)                                                          
      Mineralization                                   2 (4%)       2 (4%)       4 (8%)                                             
      Nephropathy                                     16 (32%)     21 (42%)     22 (45%)                                            
      Artery, Inflammation, Chronic                                              2 (4%)                                             
      Capsule, Fibrosis, Focal                         1 (2%)                                                                       
      Interstitial Tissue, Pigmentation                                          2 (4%)                                             
      Renal Tubule, Bacterium                                       1 (2%)                                                          
      Renal Tubule, Casts                                                        1 (2%)                                             
      Renal Tubule, Degeneration, Hyaline              1 (2%)       1 (2%)                                                          
      Renal Tubule, Dilatation                         2 (4%)       1 (2%)       4 (8%)                                             
      Renal Tubule, Necrosis                                                     4 (8%)                                             
      Renal Tubule, Pigmentation                       1 (2%)       1 (2%)                                                          
      Renal Tubule, Vacuolization Cytoplasmic                       1 (2%)                                                          
      Renal Tubule, Epithelium, Depletion Cellular     1 (2%)                                                                       
   Urinary Bladder                                    (50)         (50)         (50)                                                
      Hyperplasia, Lymphoid                            3 (6%)       6 (12%)      2 (4%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05004-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               FURAN                                           Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 02:49:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      8. MG/KG     15.                                                    
                                                   CONTROL                   MG/KG                                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          16           24           24                                                  
    Dead                                               1            5            8                                                  
    Natural Death                                                   1            1                                                  
    Dosing Accident                                                 2                                                               
    Accident                                                        1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           17           16                                                  
  Other                                                                          1                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)                                                
      Perforation                                                   2 (4%)                                                          
   Intestine Large, Cecum                             (50)         (50)         (49)                                                
      Mucosa, Epithelium, Metaplasia, Squamous                                   1 (2%)                                             
   Intestine Large, Colon                             (50)         (50)         (49)                                                
      Mucosa, Cyst                                     1 (2%)                                                                       
   Intestine Small, Duodenum                          (49)         (49)         (48)                                                
      Angiectasis                                                   1 (2%)                                                          
      Inflammation, Chronic                                                      2 (4%)                                             
      Mucosa, Hyperplasia, Papillary                                1 (2%)                                                          
      Mucosa, Ulcer                                                              1 (2%)                                             
   Intestine Small, Ileum                             (50)         (49)         (48)                                                
      Lymphoid Tissue, Hyperplasia, Lymphoid           1 (2%)       1 (2%)                                                          
   Intestine Small, Jejunum                           (50)         (49)         (48)                                                
      Lymphoid Tissue, Hyperplasia, Lymphoid                                     1 (2%)                                             
      Mucosa, Hyperplasia, Papillary                                             1 (2%)                                             
   Liver                                              (50)         (50)         (50)                                                
      Angiectasis                                                   1 (2%)       3 (6%)                                             
      Basophilic Focus                                              1 (2%)                                                          
      Basophilic Focus, Multiple, Two                                            1 (2%)                                             
      Clear Cell Focus                                              1 (2%)       1 (2%)                                             
      Clear Cell Focus, Multiple, Three                                          1 (2%)                                             
      Congestion                                                    1 (2%)                                                          
      Cyst                                             1 (2%)       1 (2%)       1 (2%)                                             
      Cyst, Multiple                                                1 (2%)                                                          
      Cytoplasmic Alteration, Focal                                              1 (2%)                                             
      Degeneration, Cystic                                          1 (2%)                                                          
      Depletion Glycogen                               2 (4%)       1 (2%)                                                          
      Eosinophilic Focus                               1 (2%)       1 (2%)       1 (2%)                                             
      Fibrosis, Focal                                  3 (6%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05004-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               FURAN                                           Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 02:49:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      8. MG/KG     15.                                                    
                                                   CONTROL                   MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hematopoietic Cell Proliferation                 4 (8%)                    2 (4%)                                             
      Hemorrhage                                                                 2 (4%)                                             
      Hyperplasia, Lymphoid                           26 (52%)     24 (48%)     22 (44%)                                            
      Hyperplasia, Multifocal                          1 (2%)      44 (88%)     49 (98%)                                            
      Infarct                                          1 (2%)      13 (26%)     11 (22%)                                            
      Infarct, Multiple, Two                                                     1 (2%)                                             
      Infiltration Cellular, Mixed Cell                2 (4%)      23 (46%)     29 (58%)                                            
      Inflammation, Multifocal                        17 (34%)      7 (14%)      2 (4%)                                             
      Mineralization                                                             3 (6%)                                             
      Mixed Cell Focus                                              5 (10%)      1 (2%)                                             
      Necrosis, Multifocal                             1 (2%)       2 (4%)       3 (6%)                                             
      Thrombosis                                                    4 (8%)       1 (2%)                                             
      Vacuolization Cytoplasmic                        8 (16%)     24 (48%)     36 (72%)                                            
      Artery, Inflammation, Chronic                                              1 (2%)                                             
      Bile Duct, Dilatation                                                      6 (12%)                                            
      Biliary Tract, Fibrosis                                      45 (90%)     49 (98%)                                            
      Biliary Tract, Hyperplasia                                   46 (92%)     49 (98%)                                            
      Biliary Tract, Inflammation, Chronic                         44 (88%)     49 (98%)                                            
      Centrilobular, Necrosis                          1 (2%)       3 (6%)       1 (2%)                                             
      Hepatocyte, Cytomegaly                           8 (16%)     45 (90%)     50 (100%)                                           
      Hepatocyte, Degeneration                                     43 (86%)     43 (86%)                                            
      Hepatocyte, Mitotic Alteration                   1 (2%)       1 (2%)                                                          
      Hepatocyte, Necrosis                             2 (4%)      39 (78%)     41 (82%)                                            
      Hepatocyte, Pigmentation                                                   1 (2%)                                             
      Kupffer Cell, Pigmentation                       2 (4%)      43 (86%)     50 (100%)                                           
      Parenchyma, Atrophy, Focal                       1 (2%)                                                                       
      Parenchyma, Atrophy, Multifocal                              45 (90%)     50 (100%)                                           
      Serosa, Fibrosis, Focal                                       1 (2%)                                                          
      Serosa, Pigmentation, Focal                                   1 (2%)                                                          
   Mesentery                                          (6)          (10)         (3)                                                 
      Fibrosis                                         1 (17%)                   1 (33%)                                            
      Hyperplasia, Lymphoid                                         1 (10%)                                                         
      Infarct                                                       1 (10%)                                                         
      Inflammation, Chronic                            1 (17%)                   1 (33%)                                            
      Mineralization                                                1 (10%)      1 (33%)                                            
      Necrosis                                                                   1 (33%)                                            
      Fat, Necrosis                                    3 (50%)                                                                      
   Pancreas                                           (50)         (50)         (50)                                                
      Atrophy, Focal                                                1 (2%)                                                          
      Atypia Cellular, Focal                                                     1 (2%)                                             
      Hyperplasia, Lymphoid                                         3 (6%)                                                          
      Duct, Dilatation                                                           1 (2%)                                             
   Salivary Glands                                    (50)         (50)         (48)                                                
      Depletion Cellular                               1 (2%)                                                                       
      Hyperplasia, Lymphoid                                         4 (8%)       4 (8%)                                             
      Adventitia, Inflammation, Chronic                             1 (2%)                                                          
   Stomach, Forestomach                               (49)         (50)         (50)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05004-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               FURAN                                           Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 02:49:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      8. MG/KG     15.                                                    
                                                   CONTROL                   MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Inflammation, Focal                              9 (18%)     13 (26%)     21 (42%)                                            
      Mineralization, Focal                                         1 (2%)                                                          
      Mucosa, Edema                                                 1 (2%)                                                          
      Mucosa, Erosion                                  2 (4%)       5 (10%)      6 (12%)                                            
      Mucosa, Hyperplasia, Papillary                   7 (14%)     14 (28%)     23 (46%)                                            
      Mucosa, Inflammation, Focal                                                1 (2%)                                             
      Mucosa, Mineralization                                                     2 (4%)                                             
      Mucosa, Ulcer                                    3 (6%)       3 (6%)       3 (6%)                                             
      Mucosa, Ulcer, Multiple, Two                                               1 (2%)                                             
   Stomach, Glandular                                 (49)         (50)         (50)                                                
      Inflammation, Focal                              1 (2%)       6 (12%)      4 (8%)                                             
      Mineralization                                                3 (6%)                                                          
      Epithelium, Degeneration, Hyaline                1 (2%)       2 (4%)                                                          
      Epithelium, Metaplasia, Squamous                              1 (2%)                                                          
      Mucosa, Cyst                                     1 (2%)       1 (2%)       1 (2%)                                             
      Mucosa, Cyst, Multiple                                        1 (2%)                                                          
      Mucosa, Dysplasia                                                          1 (2%)                                             
      Mucosa, Erosion                                               1 (2%)       1 (2%)                                             
      Mucosa, Hyperplasia                                           1 (2%)                                                          
      Mucosa, Hyperplasia, Papillary                                             1 (2%)                                             
      Mucosa, Mineralization                           1 (2%)                    1 (2%)                                             
   Tongue                                                          (1)          (1)                                                 
      Hemorrhage                                                                 1 (100%)                                           
   Tooth                                              (43)         (36)         (32)                                                
      Incisor, Dysplasia                              43 (100%)    35 (97%)     32 (100%)                                           
      Incisor, Inflammation, Suppurative               4 (9%)       3 (8%)       5 (16%)                                            
      Molar, Inflammation, Suppurative                                           1 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (2)          (2)          (4)                                                 
      Abdominal, Inflammation, Chronic                                           1 (25%)                                            
      Abdominal, Thrombosis                            1 (50%)                                                                      
      Abdominal, Adventitia, Thrombosis                                          1 (25%)                                            
      Aorta, Mineralization                                         1 (50%)                                                         
      Aorta, Media, Mineralization                                               2 (50%)                                            
      Mesenteric Artery, Inflammation, Chronic                      1 (50%)      2 (50%)                                            
      Mesenteric Artery, Media, Mineralization                                   1 (25%)                                            
      Renal Artery, Mineralization                                  1 (50%)                                                         
      Thoracic, Artery, Mineralization                 1 (50%)                                                                      
   Heart                                              (50)         (50)         (50)                                                
      Inflammation, Chronic                                                      1 (2%)                                             
      Mineralization                                                1 (2%)                                                          
      Coronary Artery, Mineralization                                            1 (2%)                                             
      Myocardium, Mineralization                                                 1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05004-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               FURAN                                           Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 02:49:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      8. MG/KG     15.                                                    
                                                   CONTROL                   MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Depletion Cellular                               1 (2%)                                                                       
      Focal Cellular Change                                         1 (2%)                                                          
      Hyperplasia                                                   1 (2%)                                                          
      Hyperplasia, Focal                               2 (4%)                    2 (4%)                                             
      Vacuolization Cytoplasmic, Focal                 1 (2%)                                                                       
      Subcapsular, Hyperplasia                                      2 (4%)                                                          
      Subcapsular, Hyperplasia, Focal                  7 (14%)      2 (4%)       1 (2%)                                             
   Adrenal Gland, Medulla                             (49)         (50)         (50)                                                
      Hyperplasia                                      2 (4%)       3 (6%)       3 (6%)                                             
      Hyperplasia, Focal                                            3 (6%)       9 (18%)                                            
      Extra Adrenal Tissue, Ectopic Tissue                                       1 (2%)                                             
   Parathyroid Gland                                  (49)         (48)         (50)                                                
      Cyst                                             1 (2%)                                                                       
      Cyst, Multiple                                                1 (2%)                                                          
      Hyperplasia                                                   1 (2%)                                                          
   Pituitary Gland                                    (50)         (44)         (48)                                                
      Cyst                                                                       1 (2%)                                             
      Pars Distalis, Angiectasis                                    1 (2%)                                                          
      Pars Distalis, Cyst                              6 (12%)      1 (2%)       3 (6%)                                             
      Pars Distalis, Focal Cellular Change                                       1 (2%)                                             
      Pars Distalis, Hyperplasia, Focal                2 (4%)       1 (2%)       1 (2%)                                             
      Pars Nervosa, Angiectasis                                     1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (50)                                                
      Degeneration                                                  1 (2%)                                                          
      Degeneration, Cystic                             6 (12%)      7 (14%)      4 (8%)                                             
      Follicle, Cyst                                                             1 (2%)                                             
      Follicular Cell, Hyperplasia                     4 (8%)       4 (8%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (1)          (1)                                                              
      Dilatation                                       1 (100%)     1 (100%)                                                        
      Hyperplasia, Adenomatous                                      1 (100%)                                                        
   Epididymis                                         (50)         (50)         (50)                                                
      Granuloma                                                     1 (2%)                                                          
      Granuloma Sperm                                               1 (2%)                                                          
      Hyperplasia, Lymphoid                            2 (4%)                    2 (4%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05004-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               FURAN                                           Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 02:49:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      8. MG/KG     15.                                                    
                                                   CONTROL                   MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
   Preputial Gland                                    (6)          (6)          (5)                                                 
      Degeneration, Cystic                             1 (17%)      4 (67%)      4 (80%)                                            
      Fibrosis                                                      1 (17%)                                                         
      Inflammation, Suppurative                        5 (83%)      3 (50%)      3 (60%)                                            
   Prostate                                           (49)         (50)         (50)                                                
      Degeneration, Cystic                             1 (2%)       1 (2%)                                                          
      Dilatation                                       1 (2%)       1 (2%)       2 (4%)                                             
      Edema                                                         2 (4%)       2 (4%)                                             
      Granuloma                                        1 (2%)                                                                       
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Inflammation, Chronic                            2 (4%)                                                                       
      Artery, Media, Hyperplasia                       1 (2%)                                                                       
   Seminal Vesicle                                    (50)         (50)         (50)                                                
      Dilatation                                       2 (4%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
   Testes                                             (50)         (50)         (50)                                                
      Granuloma Sperm                                  1 (2%)                                                                       
      Mineralization                                   1 (2%)       4 (8%)       1 (2%)                                             
      Germinal Epithelium, Degeneration                3 (6%)       2 (4%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Metaplasia, Focal, Osseous                                                 1 (2%)                                             
   Lymph Node                                         (50)         (50)         (49)                                                
      Iliac, Hyperplasia                               1 (2%)                                                                       
      Inguinal, Angiectasis                            2 (4%)                    1 (2%)                                             
      Inguinal, Congestion                             1 (2%)                                                                       
      Inguinal, Hyperplasia                            4 (8%)                    1 (2%)                                             
      Pancreatic, Hyperplasia, Lymphoid                             1 (2%)                                                          
      Pancreatic, Inflammation, Chronic, Focal         1 (2%)                                                                       
      Renal, Hyperplasia                               1 (2%)                                                                       
   Lymph Node, Bronchial                              (14)         (27)         (26)                                                
      Hyperplasia, Lymphoid                                         2 (7%)                                                          
   Lymph Node, Mandibular                             (49)         (48)         (43)                                                
      Hyperplasia                                      2 (4%)       1 (2%)                                                          
      Hyperplasia, Lymphoid                                         4 (8%)                                                          
      Pigmentation                                                  1 (2%)                                                          
   Lymph Node, Mediastinal                            (38)         (45)         (41)                                                
      Depletion Lymphoid                                                         1 (2%)                                             
      Hyperplasia                                                   1 (2%)       2 (5%)                                             
      Hyperplasia, Lymphoid                            1 (3%)       5 (11%)                                                         
   Lymph Node, Mesenteric                             (50)         (50)         (48)                                                
      Angiectasis                                     21 (42%)      7 (14%)      6 (13%)                                            
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05004-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               FURAN                                           Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 02:49:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      8. MG/KG     15.                                                    
                                                   CONTROL                   MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia                                                                1 (2%)                                             
      Hyperplasia, Lymphoid                                         2 (4%)       1 (2%)                                             
      Inflammation, Suppurative                                                  1 (2%)                                             
   Spleen                                             (50)         (50)         (49)                                                
      Depletion Cellular                               2 (4%)                                                                       
      Depletion Lymphoid                                            1 (2%)                                                          
      Hematopoietic Cell Proliferation                 5 (10%)     11 (22%)     15 (31%)                                            
      Hyperplasia, Lymphoid                            2 (4%)       7 (14%)                                                         
      Artery, Degeneration, Hyaline                                              1 (2%)                                             
      Red Pulp, Depletion Cellular                                  2 (4%)                                                          
   Thymus                                             (42)         (44)         (42)                                                
      Cyst                                             1 (2%)                                                                       
      Depletion Lymphoid                               3 (7%)       4 (9%)       1 (2%)                                             
      Hyperplasia, Lymphoid                                         3 (7%)                                                          
      Epithelial Cell, Hyperplasia                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)                                                
      Erosion                                          1 (2%)                                                                       
      Exudate                                          1 (2%)                    1 (2%)                                             
      Inflammation, Chronic                           10 (20%)      6 (12%)      7 (14%)                                            
      Ulcer                                            4 (8%)       2 (4%)       4 (8%)                                             
      Hair Follicle, Atrophy                                                     1 (2%)                                             
      Prepuce, Fibrosis                                             1 (2%)       1 (2%)                                             
      Prepuce, Inflammation, Chronic                   1 (2%)                    1 (2%)                                             
      Prepuce, Ulcer                                   1 (2%)                                                                       
      Subcutaneous Tissue, Congestion                               1 (2%)                                                          
      Subcutaneous Tissue, Edema                       1 (2%)       2 (4%)                                                          
      Subcutaneous Tissue, Inflammation, Chronic                    1 (2%)                                                          
      Subcutaneous Tissue, Inflammation,                                                                                            
          Suppurative                                  1 (2%)       1 (2%)                                                          
      Subcutaneous Tissue, Thrombosis                  1 (2%)                                                                       
      Subcutaneous Tissue, Fat, Necrosis               1 (2%)                                                                       
      Subcutaneous Tissue, Head, Hyperplasia, Mast                                                                                  
          Cell                                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Cranium, Hyperostosis                            1 (2%)                                                                       
      Distal, Joint, Femur, Arthrosis                               5 (10%)                                                         
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05004-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               FURAN                                           Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 02:49:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      8. MG/KG     15.                                                    
                                                   CONTROL                   MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Congestion                                       1 (2%)       4 (8%)       4 (8%)                                             
      Granuloma                                                                  2 (4%)                                             
      Hyperplasia, Lymphoid                           23 (46%)     20 (40%)     23 (46%)                                            
      Hyperplasia, Macrophage                         15 (30%)     12 (24%)     17 (34%)                                            
      Infiltration Cellular, Polymorphonuclear                                   1 (2%)                                             
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      Inflammation, Focal                                                        1 (2%)                                             
      Inflammation, Focal, Granulomatous                                         1 (2%)                                             
      Inflammation, Suppurative                        1 (2%)                                                                       
      Pigmentation                                                               1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 2 (4%)       3 (6%)       2 (4%)                                             
      Bronchiole, Hyperplasia                                                    1 (2%)                                             
      Bronchus, Epithelium, Hyperplasia, Papillary     1 (2%)                                                                       
      Mediastinum, Foreign Body                                     2 (4%)                                                          
      Mediastinum, Hemorrhage                                                    1 (2%)                                             
      Mediastinum, Inflammation, Suppurative                        2 (4%)                                                          
      Pleura, Inflammation, Suppurative                             1 (2%)                                                          
   Nose                                               (50)         (50)         (50)                                                
      Lumen, Exudate                                  16 (32%)      9 (18%)      1 (2%)                                             
      Lumen, Foreign Body                             16 (32%)     13 (26%)      6 (12%)                                            
      Lumen, Hemorrhage                                2 (4%)                                                                       
      Lumen, Inflammation, Suppurative                 2 (4%)       2 (4%)       3 (6%)                                             
      Mucosa, Inflammation, Suppurative                1 (2%)                    1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Suppurative     1 (2%)       2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Atrophy                                                       1 (2%)       1 (2%)                                             
      Congestion                                                    3 (6%)       1 (2%)                                             
      Cyst                                                          1 (2%)                                                          
      Fibrosis                                         2 (4%)       2 (4%)       1 (2%)                                             
      Fibrosis, Focal                                  1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
NTP Experiment-Test: 05004-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                               FURAN                                           Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 02:49:48  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      8. MG/KG     15.                                                    
                                                   CONTROL                   MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Hydronephrosis                                   1 (2%)       3 (6%)       4 (8%)                                             
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)                                                          
      Infarct                                                       2 (4%)                                                          
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Suppurative                                     1 (2%)                                                          
      Metaplasia, Osseous                              1 (2%)       1 (2%)                                                          
      Mineralization                                  36 (72%)     34 (68%)     41 (82%)                                            
      Nephropathy                                     41 (82%)     36 (72%)     38 (76%)                                            
      Thrombosis                                                    1 (2%)                                                          
      Capsule, Fibrosis                                                          1 (2%)                                             
      Papilla, Necrosis                                1 (2%)                                                                       
      Pelvis, Dilatation                               1 (2%)                                                                       
      Renal Tubule, Cyst                               3 (6%)                                                                       
      Renal Tubule, Dilatation                         3 (6%)       2 (4%)                                                          
      Renal Tubule, Necrosis                           1 (2%)                                                                       
      Renal Tubule, Pigmentation                       1 (2%)                                                                       
      Renal Tubule, Vacuolization Cytoplasmic          6 (12%)      2 (4%)                                                          
   Ureter                                             (1)          (2)          (2)                                                 
      Mineralization                                                1 (50%)                                                         
      Necrosis                                                      1 (50%)                                                         
      Serosa, Hyperplasia, Lymphoid                                 1 (50%)      2 (100%)                                           
   Urinary Bladder                                    (50)         (49)         (50)                                                
      Hemorrhage                                       1 (2%)                    1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)                    2 (4%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
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