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TDMS Study 05004-04 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                               FURAN


NTP Experiment-Test: 05004-04                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/03/94
Route: GAVAGE                                                                                                     Time: 02:49:52




       Facility:  Southern Research Institute

       Chemical CAS #:  110-00-9

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05004-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               FURAN                                           Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 02:49:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      8. MG/KG     15.                                                    
                                                   CONTROL                   MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          16           16           35                                                  
    Natural Death                                      1            1                                                               
    Dead                                               4            8           11                                                  
    Dosing Accident                                                              1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           25            2                                                  
    Dead                                               1                                                                            
  Other                                                                          1                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)                                                
      Squamous Cell Papilloma                          1 (2%)                                                                       
   Gallbladder                                        (49)         (49)         (43)                                                
   Intestine Small, Duodenum                          (49)         (47)         (45)                                                
      Polyp Adenomatous                                1 (2%)                                                                       
   Intestine Small, Ileum                             (48)         (47)         (44)                                                
   Liver                                              (50)         (50)         (50)                                                
      Carcinoma                                                     1 (2%)                                                          
      Hemangiosarcoma                                                            1 (2%)                                             
      Hepatocellular Carcinoma                         2 (4%)       6 (12%)     22 (44%)                                            
      Hepatocellular Carcinoma, Multiple, Two                                    4 (8%)                                             
      Hepatocellular Carcinoma, Multiple, Three                                  1 (2%)                                             
      Hepatocellular Adenoma                           5 (10%)     17 (34%)      8 (16%)                                            
      Hepatocellular Adenoma, Multiple, Two                         8 (16%)      4 (8%)                                             
      Hepatocellular Adenoma, Multiple, Three                       4 (8%)      10 (20%)                                            
      Hepatocellular Adenoma, Multiple, Four                        2 (4%)       4 (8%)                                             
      Hepatocellular Adenoma, Multiple, Five                                     8 (16%)                                            
      Hepatocellular Adenoma, Multiple, Greater                                                                                     
          Than Five                                                             14 (28%)                                            
      Sarcoma, Metastatic                                           1 (2%)                                                          
      Sarcoma Stromal, Metastatic, Uterus              1 (2%)                                                                       
   Mesentery                                          (24)         (27)         (4)                                                 
      Carcinoma, Metastatic, Liver                                  1 (4%)                                                          
      Hemangiosarcoma                                               1 (4%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (25%)                                            
      Sarcoma, Metastatic                              1 (4%)       1 (4%)                                                          
      Sarcoma Stromal, Metastatic, Uterus              1 (4%)                                                                       
   Pancreas                                           (50)         (49)         (50)                                                
      Carcinoma, Metastatic, Liver                                  1 (2%)                                                          
                                                             Page   2                                                               
NTP Experiment-Test: 05004-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               FURAN                                           Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 02:49:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      8. MG/KG     15.                                                    
                                                   CONTROL                   MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Sarcoma, Metastatic                              1 (2%)       1 (2%)                                                          
      Sarcoma Stromal, Metastatic, Uterus              1 (2%)                                                                       
   Salivary Glands                                    (50)         (50)         (50)                                                
      Adventitia, Hemangioma                           1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (49)         (49)                                                
      Mucosa, Squamous Cell Papilloma                  2 (4%)       6 (12%)      3 (6%)                                             
   Stomach, Glandular                                 (49)         (49)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Extra Adrenal Tissue, Carcinoma, Metastatic,                                                                                  
           Liver                                                    1 (2%)                                                          
      Subcapsular, Adenoma                                                       1 (2%)                                             
   Adrenal Gland, Medulla                             (50)         (50)         (50)                                                
      Pheochromocytoma Benign                          2 (4%)       1 (2%)       3 (6%)                                             
      Pheochromocytoma Benign, Multiple                                          3 (6%)                                             
   Islets, Pancreatic                                 (50)         (50)         (50)                                                
      Carcinoma                                                     1 (2%)                                                          
   Pituitary Gland                                    (49)         (47)         (46)                                                
      Adenoma                                                       1 (2%)                                                          
      Pars Distalis, Adenoma                          25 (51%)     18 (38%)      9 (20%)                                            
      Pars Distalis, Carcinoma                         1 (2%)                                                                       
      Pars Intermedia, Adenoma                                                   1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (50)                                                
      Follicular Cell, Adenoma                         2 (4%)       3 (6%)       1 (2%)                                             
      Follicular Cell, Adenoma, Multiple, Two                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (1)                                                              
      Abdominal, Sarcoma                               1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (49)         (49)         (50)                                                
      Cystadenoma, Papillary                                                     1 (2%)                                             
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
      Granulosa-Theca Tumor Benign                     1 (2%)                                                                       
                                                             Page   3                                                               
NTP Experiment-Test: 05004-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               FURAN                                           Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 02:49:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      8. MG/KG     15.                                                    
                                                   CONTROL                   MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Periovarian Tissue, Carcinoma, Metastatic,                                                                                    
           Liver                                                    1 (2%)                                                          
   Oviduct                                            (4)          (4)          (1)                                                 
      Carcinoma, Metastatic, Liver                                  1 (25%)                                                         
   Uterus                                             (50)         (50)         (50)                                                
      Hemangiosarcoma                                  1 (2%)                                                                       
      Sarcoma Stromal                                  2 (4%)                                                                       
      Endometrium, Polyp Stromal                       1 (2%)                    4 (8%)                                             
      Endometrium, Polyp Stromal, Multiple             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (1)          (1)                                                              
   Bone Marrow                                        (50)         (50)         (50)                                                
      Hemangiosarcoma                                  1 (2%)                                                                       
   Lymph Node                                         (50)         (50)         (50)                                                
   Lymph Node, Bronchial                              (21)         (29)         (21)                                                
   Lymph Node, Mandibular                             (47)         (46)         (48)                                                
   Lymph Node, Mediastinal                            (41)         (45)         (43)                                                
   Lymph Node, Mesenteric                             (49)         (49)         (49)                                                
   Spleen                                             (50)         (50)         (50)                                                
      Hemangiosarcoma                                  1 (2%)                    2 (4%)                                             
   Thymus                                             (46)         (46)         (45)                                                
      Epithelial Cell, Thymoma Benign                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (50)         (48)                                                
      Adenocarcinoma                                   2 (4%)       1 (2%)       3 (6%)                                             
      Carcinoma                                        1 (2%)                                                                       
   Skin                                               (50)         (50)         (50)                                                
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Head, Sebaceous Gland, Adenoma                                1 (2%)                                                          
      Sebaceous Gland, Adenoma                                      1 (2%)                                                          
      Subcutaneous Tissue, Hemangiosarcoma                                       1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                                  1 (2%)                                                          
      Subcutaneous Tissue, Sarcoma, Metastatic                      1 (2%)                                                          
      Tail, Squamous Cell Papilloma                                              1 (2%)                                             
      Tail, Subcutaneous Tissue, Sarcoma                            1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05004-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               FURAN                                           Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 02:49:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      8. MG/KG     15.                                                    
                                                   CONTROL                   MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (3)          (2)                                                              
      Abdominal, Sarcoma                                            1 (50%)                                                         
      Diaphragm, Sarcoma, Metastatic                                1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Meningioma Benign                                                          1 (2%)                                             
   Peripheral Nerve                                   (1)                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Adenocarcinoma, Multiple, Metastatic,                                                                                         
          Greater Than Five, Mammary Gland                                       1 (2%)                                             
      Alveolar/Bronchiolar Adenoma                     3 (6%)       4 (8%)       3 (6%)                                             
      Alveolar/Bronchiolar Carcinoma                   2 (4%)       2 (4%)       1 (2%)                                             
      Hemangiosarcoma                                               1 (2%)                                                          
      Hepatocellular Carcinoma, Multiple,                                                                                           
          Metastatic, Three, Liver                     1 (2%)                                                                       
      Hepatocellular Carcinoma, Multiple,                                                                                           
          Metastatic, Four, Liver                                                1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)                    1 (2%)                                             
      Sarcoma, Metastatic                                           1 (2%)                                                          
      Parenchyma, Mediastinum, Carcinoma,                                                                                           
          Metastatic, Liver                                         1 (2%)                                                          
   Nose                                               (50)         (50)         (50)                                                
   Trachea                                            (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (4)          (6)          (4)                                                 
      Adenoma                                          2 (50%)      4 (67%)      2 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)                                                
   Urinary Bladder                                    (50)         (50)         (50)                                                
                                                             Page   5                                                               
NTP Experiment-Test: 05004-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               FURAN                                           Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 02:49:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      8. MG/KG     15.                                                    
                                                   CONTROL                   MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Lymphoma Malignant Lymphocytic                   3 (6%)       3 (6%)                                                          
      Lymphoma Malignant Mixed                        17 (34%)     11 (22%)      7 (14%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   6                                                               
NTP Experiment-Test: 05004-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               FURAN                                           Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 02:49:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      8. MG/KG     15.                                                    
                                                   CONTROL                   MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            43          43          50                                                   
     Total Primary Neoplasms                           83         101         124                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 34          38          48                                                   
     Total Benign Neoplasms                            48          71          82                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              30          24          32                                                   
     Total Malignant Neoplasms                         35          30          42                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4           2           3                                                   
     Total Metastatic Neoplasm                          7          12           4                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   7                                                               
NTP Experiment-Test: 05004-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               FURAN                                           Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 02:49:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      8. MG/KG     15.                                                    
                                                   CONTROL                   MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          16           24           24                                                  
    Dead                                               1            5            8                                                  
    Natural Death                                                   1            1                                                  
    Dosing Accident                                                 2                                                               
    Accident                                                        1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           17           16                                                  
  Other                                                                          1                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (50)         (48)         (44)                                                
      Adenocarcinoma, Metastatic, Liver                             1 (2%)                                                          
   Intestine Small, Duodenum                          (49)         (49)         (48)                                                
      Adenocarcinoma, Metastatic, Uncertain                                                                                         
          Primary Site                                              1 (2%)                                                          
      Serosa, Sarcoma, Metastatic, Uncertain                                                                                        
          Primary Site                                              1 (2%)                                                          
   Intestine Small, Jejunum                           (50)         (49)         (48)                                                
      Adenocarcinoma                                   1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)                                                
      Adenocarcinoma, Metastatic, Uncertain                                                                                         
          Primary Site                                              1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
      Carcinoma, Multiple, Metastatic, Harderian                                                                                    
          Gland                                                     1 (2%)                                                          
      Hemangiosarcoma                                  2 (4%)       1 (2%)       2 (4%)                                             
      Hemangiosarcoma, Multiple, Two                                2 (4%)                                                          
      Hemangiosarcoma, Multiple, Three                              1 (2%)                                                          
      Hepatoblastoma                                   1 (2%)                                                                       
      Hepatocellular Carcinoma                         5 (10%)     26 (52%)     27 (54%)                                            
      Hepatocellular Carcinoma, Multiple                            2 (4%)                                                          
      Hepatocellular Carcinoma, Multiple, Two          1 (2%)       3 (6%)       5 (10%)                                            
      Hepatocellular Carcinoma, Multiple, Three                     1 (2%)       1 (2%)                                             
      Hepatocellular Carcinoma, Multiple, Four                                   1 (2%)                                             
      Hepatocellular Carcinoma, Two                    1 (2%)                                                                       
      Hepatocellular Adenoma                          18 (36%)     16 (32%)     12 (24%)                                            
      Hepatocellular Adenoma, Multiple, Two            1 (2%)       8 (16%)     11 (22%)                                            
      Hepatocellular Adenoma, Multiple, Three                       6 (12%)      8 (16%)                                            
                                                             Page   8                                                               
NTP Experiment-Test: 05004-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               FURAN                                           Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 02:49:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      8. MG/KG     15.                                                    
                                                   CONTROL                   MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Hepatocellular Adenoma, Multiple, Four                        1 (2%)       4 (8%)                                             
      Hepatocellular Adenoma, Multiple, Five                        1 (2%)       2 (4%)                                             
      Hepatocellular Adenoma, Multiple, Greater                                                                                     
          Than Five                                                 1 (2%)       3 (6%)                                             
      Hepatocellular Adenoma, Two                      1 (2%)                    2 (4%)                                             
      Hepatocholangiocarcinoma                                      2 (4%)                                                          
      Ito Cell Tumor Benign                                                      1 (2%)                                             
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (2%)                                                          
      Biliary Tract, Adenocarcinoma                                 2 (4%)       2 (4%)                                             
   Mesentery                                          (6)          (10)         (3)                                                 
      Adenocarcinoma, Multiple, Metastatic,                                                                                         
          Uncertain Primary Site                                    1 (10%)                                                         
      Adenocarcinoma, Multiple, Metastatic,                                                                                         
          Greater Than Five, Liver                                               1 (33%)                                            
      Adenocarcinoma, Metastatic, Liver                             2 (20%)                                                         
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (10%)                                                         
      Carcinoma, Metastatic, Harderian Gland                        1 (10%)                                                         
      Hemangiosarcoma                                  1 (17%)                                                                      
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (10%)                                                         
      Hepatocholangiocarcinoma, Multiple,                                                                                           
          Metastatic, Liver                                         1 (10%)                                                         
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (10%)                                                         
   Pancreas                                           (50)         (50)         (50)                                                
      Adenocarcinoma, Metastatic, Liver                             1 (2%)       1 (2%)                                             
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (2%)                                                          
   Salivary Glands                                    (50)         (50)         (48)                                                
   Stomach, Forestomach                               (49)         (50)         (50)                                                
      Mucosa, Squamous Cell Papilloma                               1 (2%)       3 (6%)                                             
   Stomach, Glandular                                 (49)         (50)         (50)                                                
      Carcinoid Tumor Malignant                                     1 (2%)       1 (2%)                                             
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (2%)                                                          
   Tooth                                              (43)         (36)         (32)                                                
      Peridontal Tissue, Carcinoma, Metastatic,                                                                                     
           Harderian Gland                                          1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
      Carcinoma, Multiple, Metastatic, Harderian                                                                                    
          Gland                                                     1 (2%)                                                          
      Hemangiosarcoma                                                            1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver                   3 (6%)                                                          
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)                                                          
                                                             Page   9                                                               
NTP Experiment-Test: 05004-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               FURAN                                           Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 02:49:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      8. MG/KG     15.                                                    
                                                   CONTROL                   MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Adenoma                                          2 (4%)       1 (2%)                                                          
      Carcinoma, Metastatic, Harderian Gland                        1 (2%)                                                          
      Extra Adrenal Tissue, Sarcoma, Metastatic,                                                                                    
           Uncertain Primary Site                                   1 (2%)                                                          
      Subcapsular, Adenoma                             3 (6%)       2 (4%)                                                          
      Subcapsular, Adenoma, Multiple                   1 (2%)                                                                       
   Adrenal Gland, Medulla                             (49)         (50)         (50)                                                
      Pheochromocytoma Benign                                       5 (10%)      7 (14%)                                            
      Pheochromocytoma Benign, Multiple                1 (2%)       1 (2%)       3 (6%)                                             
   Pituitary Gland                                    (50)         (44)         (48)                                                
      Pars Distalis, Adenoma                                                     1 (2%)                                             
      Pars Intermedia, Adenoma                                      1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (50)                                                
      Follicular Cell, Adenoma                         1 (2%)                                                                       
      Follicular Cell, Carcinoma                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ductus Deferens                                    (1)          (2)                                                              
   Epididymis                                         (50)         (50)         (50)                                                
   Preputial Gland                                    (6)          (6)          (5)                                                 
      Adenoma                                          1 (17%)                                                                      
   Prostate                                           (49)         (50)         (50)                                                
   Seminal Vesicle                                    (50)         (50)         (50)                                                
      Adenocarcinoma, Metastatic, Liver                             1 (2%)                                                          
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (2%)                                                          
   Testes                                             (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
      Hemangiosarcoma                                  2 (4%)                    1 (2%)                                             
   Lymph Node                                         (50)         (50)         (49)                                                
   Lymph Node, Bronchial                              (14)         (27)         (26)                                                
   Lymph Node, Mandibular                             (49)         (48)         (43)                                                
   Lymph Node, Mediastinal                            (38)         (45)         (41)                                                
                                                             Page  10                                                               
NTP Experiment-Test: 05004-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               FURAN                                           Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 02:49:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      8. MG/KG     15.                                                    
                                                   CONTROL                   MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Adenocarcinoma, Metastatic, Liver                             1 (2%)       1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)                                                          
      Sarcoma, Metastatic, Uncertain Primary Site                   1 (2%)                                                          
   Lymph Node, Mesenteric                             (50)         (50)         (48)                                                
      Adenocarcinoma, Metastatic, Liver                             1 (2%)                                                          
   Spleen                                             (50)         (50)         (49)                                                
      Adenocarcinoma, Metastatic, Liver                             1 (2%)                                                          
      Hemangiosarcoma                                  3 (6%)                    2 (4%)                                             
   Thymus                                             (42)         (44)         (42)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)                                                
      Fibrosarcoma                                     1 (2%)                                                                       
      Squamous Cell Papilloma                                       1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                     3 (6%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                             3 (6%)       1 (2%)                                             
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
      Subcutaneous Tissue, Neurofibroma                             1 (2%)                                                          
      Subcutaneous Tissue, Sarcoma                                  2 (4%)       2 (4%)                                             
      Subcutaneous Tissue, Sarcoma, Multiple           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Cranium, Carcinoma, Metastatic, Harderian                                                                                     
          Gland                                                     1 (2%)                                                          
      Cranium, Hemangiosarcoma                                      1 (2%)                                                          
   Skeletal Muscle                                    (2)          (3)          (1)                                                 
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (33%)                                                         
      Back, Hemangiosarcoma                            1 (50%)                                                                      
      Diaphragm, Intercostal, Alveolar/Bronchiolar                                                                                  
          Carcinoma, Multiple, Metastatic, Lung                     1 (33%)                                                         
      Head, Carcinoma, Metastatic, Harderian Gland                  1 (33%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (49)                                                
      Adenocarcinoma, Metastatic, Liver                             1 (2%)                                                          
      Carcinoma, Metastatic, Harderian Gland                        1 (2%)                                                          
      Meninges, Hemangiosarcoma                                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                             Page  11                                                               
NTP Experiment-Test: 05004-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               FURAN                                           Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 02:49:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      8. MG/KG     15.                                                    
                                                   CONTROL                   MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Adenocarcinoma, Multiple, Metastatic,                                                                                         
          Uncertain Primary Site                                    1 (2%)                                                          
      Adenocarcinoma, Multiple, Metastatic,                                                                                         
          Greater Than Five, Liver                                               1 (2%)                                             
      Adenocarcinoma, Metastatic, Liver                             1 (2%)                                                          
      Alveolar/Bronchiolar Adenoma                     7 (14%)      6 (12%)     12 (24%)                                            
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)                                                                       
      Alveolar/Bronchiolar Adenoma, Multiple, Two      1 (2%)       1 (2%)       4 (8%)                                             
      Alveolar/Bronchiolar Carcinoma                   3 (6%)       2 (4%)                                                          
      Carcinoma                                        1 (2%)                                                                       
      Hepatocellular Carcinoma, Multifocal,                                                                                         
          Metastatic, Greater Than Five, Liver                                   1 (2%)                                             
      Hepatocellular Carcinoma, Multiple,                                                                                           
          Metastatic, Liver                            1 (2%)       1 (2%)                                                          
      Hepatocellular Carcinoma, Multiple,                                                                                           
          Metastatic, Three, Liver                                  1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic                          1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      2 (4%)       4 (8%)       2 (4%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)                                                          
      Mediastinum, Adenocarcinoma, Metastatic,                                                                                      
           Liver                                                    1 (2%)                                                          
      Mediastinum, Sarcoma, Metastatic, Uncertain                                                                                   
          Primary Site                                              1 (2%)                                                          
      Parenchyma, Mediastinum,                                                                                                      
          Alveolar/Bronchiolar Carcinoma, Multiple                  1 (2%)                                                          
      Parenchyma, Mediastinum, Carcinoma, Multiple,                                                                                 
           Metastatic, Harderian Gland                              1 (2%)                                                          
   Nose                                               (50)         (50)         (50)                                                
      Mucosa, Carcinoma, Metastatic, Harderian                                                                                      
          Gland                                                     1 (2%)                                                          
      Mucosa, Hemangiosarcoma                                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                          (1)                                                 
      Glioma Malignant, Metastatic                                               1 (100%)                                           
   Eye                                                             (1)                                                              
      Carcinoma, Metastatic, Harderian Gland                        1 (100%)                                                        
   Harderian Gland                                    (3)          (5)                                                              
      Adenoma                                          3 (100%)     4 (80%)                                                         
      Carcinoma                                                     1 (20%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  12                                                               
NTP Experiment-Test: 05004-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               FURAN                                           Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 02:49:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      8. MG/KG     15.                                                    
                                                   CONTROL                   MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Adenocarcinoma, Metastatic, Liver                             1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma, Multiple,                                                                                     
           Metastatic, Lung                                         1 (2%)                                                          
      Hepatocellular Carcinoma, Multiple,                                                                                           
          Metastatic, Liver                                         1 (2%)                                                          
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)                                                          
      Adventitia, Adenocarcinoma, Metastatic, Liver                 1 (2%)                                                          
      Capsule, Sarcoma, Metastatic, Uncertain                                                                                       
          Primary Site                                              1 (2%)                                                          
   Urinary Bladder                                    (50)         (49)         (50)                                                
      Transitional Epithelium, Papilloma               1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Lymphoma Malignant Histiocytic                                1 (2%)       1 (2%)                                             
      Lymphoma Malignant Mixed                         5 (10%)     11 (22%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  13                                                               
NTP Experiment-Test: 05004-04  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                               FURAN                                           Date: 09/03/94  
Route: GAVAGE                                                                                                     Time: 02:49:52  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      8. MG/KG     15.                                                    
                                                   CONTROL                   MG/KG                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            43          45          50                                                   
     Total Primary Neoplasms                           75         122         121                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 32          38          46                                                   
     Total Benign Neoplasms                            45          57          73                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              19          41          39                                                   
     Total Malignant Neoplasms                         30          65          48                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3          10           3                                                   
     Total Metastatic Neoplasm                          3          62           8                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           3                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  14                                                               
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