National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2686

TDMS Study 05004-04 Pathology Tables

NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97
Route: GAVAGE                                                                                                     Time: 08:03:20




       Facility:  Southern Research Institute

       Chemical CAS #:  110-00-9

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 9| 2| 3| 3| 8| 5| 1| 3| 3| 8| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3|             
                                           | 4| 8| 4| 6| 6| 5| 7| 8| 6| 6| 0| 8| 8| 8| 8| 6| 7| 8| 8| 8| 4| 9| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Mineralization      |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |       2        2        1                                1  2            |             
      Hyperplasia, Lymphoid                |    1     1  1           1     2  2  1  1  2        2        2            |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Inflammation, Multifocal             |    1     2  1           1  1     2  1  1  1  2  1  1  1  1           1   |             
      Mixed Cell Focus                     |                                                       2                  |             
      Necrosis, Multifocal                 |             1                                                            |             
      Vacuolization Cytoplasmic            |                2                 2                                       |             
      Biliary Tract, Inflammation, Chronic |                                                             2            |             
      Kupffer Cell, Pigmentation           |                                  1           2              1            |             
                                            __________________________________________________________________________|             
   Mesentery                               | +     +     +     +  +     +  +        +        +           +  +  +     +|             
      Edema                                |                               2                                          |             
      Inflammation, Suppurative            |                                                             3            |             
      Fat, Necrosis                        |             2                                                     3      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                          |             
      Infarct                              | 4                                                                        |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1                                                                        |             
      Inflammation, Focal                  |                                     1           1                        |             
      Mineralization                       | 1                                                                        |             
      Mucosa, Erosion                      |                                                                          |             
      Mucosa, Hyperplasia, Papillary       |                                     1     1     2                        |             
      Mucosa, Ulcer                        |                                                 1                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Focal                  |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 9| 2| 3| 3| 8| 5| 1| 3| 3| 8| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3|             
                                           | 4| 8| 4| 6| 6| 5| 7| 8| 6| 6| 0| 8| 8| 8| 8| 6| 7| 8| 8| 8| 4| 9| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Epithelium, Degeneration, Hyaline    |                                                    2              2      |             
      Epithelium, Metaplasia, Squamous     |                                                    2              2      |             
      Mucosa, Cyst                         |                      2  2        1                 2              2     2|             
      Mucosa, Erosion                      |                   2                                                      |             
      Mucosa, Hyperplasia                  |                      2                                            2      |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Incisor, Dysplasia                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +                                                           +            |             
      Mesenteric Artery, Inflammation,     |                                                                          |             
           Chronic                         |                                                             2            |             
      Pulmonary Artery, Mineralization     | 1                                                                        |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium, Thrombosis                   |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Subcapsular, Hyperplasia, Focal      |                                              2                           |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                 2           1            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                  3                 3              2      |             
      Pars Distalis, Cyst                  |                      1                                                   |             
      Pars Distalis, Hyperplasia, Focal    |             1                                                     2      |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |             1                                         1              1   |             
      Follicular Cell, Hyperplasia         |       2  1           1     2              2           2              2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                    2                     |             
      Inflammation, Suppurative            |                                                             4            |             
      Follicle, Cyst                       |    2  3        2        3     4     3     3     2              1        3|             
                                            __________________________________________________________________________|             
   Oviduct                                 |       +                                                     +            |             
      Inflammation, Suppurative            |                                                             4            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 9| 2| 3| 3| 8| 5| 1| 3| 3| 8| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3|             
                                           | 4| 8| 4| 6| 6| 5| 7| 8| 6| 6| 0| 8| 8| 8| 8| 6| 7| 8| 8| 8| 4| 9| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                                     3     3        2              2  2   |             
      Inflammation, Suppurative            |                4                                            3            |             
      Thrombosis                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 3  3  4  4  2  3  2  3  3  4  2     3  3  4  3  3  4  3  3  3  2  4  4  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +                                                                        |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Neutrophil              |                3                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Iliac, Hyperplasia                   |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
      Renal, Hyperplasia                   |                                                             3            |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  M  +  M  +  M  M  M  M  +  M  +  M  M  M  M  +  M  M  +  M  +  +  +  M|             
      Hyperplasia, Lymphoid                |                                  2                                       |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      2                                                   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia                          |             2                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  M  +  M  M  +  M  M  +  M  M  M  +  +  M  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia                          |                                                             1            |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |             2                    2                       2           2   |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 3     3     3  3                                         2  3            |             
      Hyperplasia, Lymphoid                |          2  1  2                                                         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M|             
      Depletion Lymphoid                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |    1  1  1           2        2           2     3                        |             
      Hyperplasia, Cystic                  |                                                 2                        |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |          1  2                                                     1      |             
      Ulcer                                |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 9| 2| 3| 3| 8| 5| 1| 3| 3| 8| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3|             
                                           | 4| 8| 4| 6| 6| 5| 7| 8| 6| 6| 0| 8| 8| 8| 8| 6| 7| 8| 8| 8| 4| 9| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +                 +                                                     +|             
      Necrosis, Multifocal                 | 1                                                                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Hemorrhage, Focal                    |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Peripheral Nerve                        |       +                                                                  |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |    1           1        2        1     1  2  1     2                 2   |             
      Hyperplasia, Macrophage              |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Mediastinum, Hyperplasia, Lymphoid   |                                                             2            |             
      Mediastinum, Inflammation,           |                                                                          |             
          Suppurative                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Exudate                       |       1  1  1     1              2  2  1     1  2  1  1        3        3|             
      Lumen, Foreign Body                  |       1  1  1     1           2  2  2        1  2  1           3        3|             
      Mucosa, Cyst                         | 2                                                                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Peritracheal Tissue,         |                                                                          |             
          Inflammation, Chronic            |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                             +            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +  +        +                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Fibrosis                             |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |                                  1                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 7| 7| 7| 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 9| 2| 3| 3| 8| 5| 1| 3| 3| 8| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 3| 3|             
                                           | 4| 8| 4| 6| 6| 5| 7| 8| 6| 6| 0| 8| 8| 8| 8| 6| 7| 8| 8| 8| 4| 9| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Nephropathy                          |          1              1  2  3           1     2  1  1                  |             
      Capsule, Fibrosis, Focal             |                                                             2            |             
      Renal Tubule, Degeneration, Hyaline  | 3                                                                        |             
      Renal Tubule, Dilatation             |                               3                             1            |             
      Renal Tubule, Pigmentation           |                                                                          |             
      Renal Tubule, Epithelium, Depletion  |                                                                          |             
          Cellular                         | 3                                                                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                             1            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 7| 4| 6| 7| 7| 7|            |
                             DAY ON TEST   | 5| 2| 8| 3| 3| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 9| 2| 3| 1| 4| 3| 3| 3|            |
                                           | 7| 3| 0| 8| 8| 3| 4| 8| 8| 8| 8| 8| 8| 8| 8| 0| 0| 5| 5| 8| 4| 2| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  48        |
      Lymphoid Tissue, Mineralization      |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |    2  3                                                                  |      2  2.5|
      Hematopoietic Cell Proliferation     | 2                                2                 2  2        3  1      |     11  1.8|
      Hyperplasia, Lymphoid                |          2  1  2  1  2  1  1  1  2  1     1           2  1     1     1  1|     27  1.4|
      Infiltration Cellular, Mixed Cell    | 2  2  2                          2           1     2  2        2         |      8  1.9|
      Inflammation, Multifocal             |             1  1  1  2  2     1  2  1  1  1           3  1               |     27  1.3|
      Mixed Cell Focus                     |                                                                          |      1  2.0|
      Necrosis, Multifocal                 |                      1                                      2            |      3  1.3|
      Vacuolization Cytoplasmic            |                1     1  2        2                                       |      6  1.7|
      Biliary Tract, Inflammation, Chronic |                                              1                           |      2  1.5|
      Kupffer Cell, Pigmentation           |                                                       1           2      |      5  1.4|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +  +  +                       +     +        +  +  +           +  +   |  24        |
      Edema                                |                                                                          |      1  2.0|
      Inflammation, Suppurative            | 3  4  4                          4              1  4  4                  |      8  3.4|
      Fat, Necrosis                        |                                                                   3  3   |      4  2.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy, Focal                       |                                                                   3      |      1  3.0|
      Infarct                              |                                                                          |      1  4.0|
      Inflammation, Suppurative            | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |                                                          2              2|      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation, Focal                  |             2           2        2  1           2     2  2     2         |     10  1.7|
      Mineralization                       |                                                                          |      1  1.0|
      Mucosa, Erosion                      |                                                 2                        |      1  2.0|
      Mucosa, Hyperplasia, Papillary       |             2           2        2              2     2  2     2         |     10  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 7| 4| 6| 7| 7| 7|            |
                             DAY ON TEST   | 5| 2| 8| 3| 3| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 9| 2| 3| 1| 4| 3| 3| 3|            |
                                           | 7| 3| 0| 8| 8| 3| 4| 8| 8| 8| 8| 8| 8| 8| 8| 0| 0| 5| 5| 8| 4| 2| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mucosa, Ulcer                        |             2                                                            |      2  1.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Lymphoid                |                      1                                                   |      1  1.0|
      Inflammation, Focal                  |                                  2                                       |      1  2.0|
      Mineralization                       |                                                             1            |      1  1.0|
      Epithelium, Degeneration, Hyaline    |                                                                          |      2  2.0|
      Epithelium, Metaplasia, Squamous     |                                                                          |      2  2.0|
      Mucosa, Cyst                         |                                  2  2           2              2        2|     11  1.9|
      Mucosa, Erosion                      |                                                                          |      1  2.0|
      Mucosa, Hyperplasia                  |                                     2                                    |      3  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                      +                                                  +|   2        |
      Incisor, Dysplasia                   |                      3                                                  1|      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   2        |
      Mesenteric Artery, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|
      Pulmonary Artery, Mineralization     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrium, Thrombosis                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                       2                  |      1  2.0|
      Subcapsular, Hyperplasia, Focal      |                                     4     1                    2         |      4  2.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           |                                                                          |      3  2.7|
      Pars Distalis, Cyst                  |                                                                          |      1  1.0|
      Pars Distalis, Hyperplasia, Focal    |          2  2        1        2                 2  2                     |      8  1.8|
      Pars Distalis, Hyperplasia           |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                               2                                          |      4  1.3|
      Follicular Cell, Hyperplasia         |       2     2                          3                 2        1  1  2|     14  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 7| 4| 6| 7| 7| 7|            |
                             DAY ON TEST   | 5| 2| 8| 3| 3| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 9| 2| 3| 1| 4| 3| 3| 3|            |
                                           | 7| 3| 0| 8| 8| 3| 4| 8| 8| 8| 8| 8| 8| 8| 8| 0| 0| 5| 5| 8| 4| 2| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                      2   |      2  2.0|
      Inflammation, Suppurative            | 4  4  4                          4                 4  4                  |      7  4.0|
      Follicle, Cyst                       |          4  2  2  2           4           3           1  1     2         |     19  2.5|
                                            __________________________________________________________________________|____________|
   Oviduct                                 | +                                +                                       |   4        |
      Inflammation, Suppurative            | 2                                4                                       |      3  3.3|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrometra                           |                               2                       1              2   |      8  2.1|
      Inflammation, Suppurative            | 3  2  2                          3                 4  4                  |      8  3.1|
      Thrombosis                           |                                              2                           |      1  2.0|
      Endometrium, Hyperplasia, Cystic     | 3  2  3  3  4  3  3  2  4  3  4  3  3  4  4  2  3  3  3  3     3  3  4  4|     48  3.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Neutrophil              |                                                                3         |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Iliac, Hyperplasia, Lymphoid         |       3                                                                  |      1  3.0|
      Iliac, Hyperplasia                   | 2                                                     3                  |      2  2.5|
      Inguinal, Hyperplasia, Lymphoid      |             2           1                                2               |      3  1.7|
      Renal, Hyperplasia, Lymphoid         |       3                                                                  |      1  3.0|
      Renal, Hyperplasia                   | 4  3                                               3  3                  |      5  3.2|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  +  +  M  M  +  +  M  +  +  M  M  M  M  M  M  +  +  M  M  M  +  +|  21        |
      Hyperplasia, Lymphoid                |             1                                            3              1|      4  1.8|
      Hyperplasia                          |                                                       3                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +|  47        |
      Cyst                                 |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                          2               |      1  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  41        |
      Hyperplasia, Lymphoid                |             2                                                            |      1  2.0|
      Hyperplasia                          | 3  2  3                       2                    3  3                  |      7  2.4|
      Inflammation, Suppurative            | 3  2                                                                     |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Lymphoid                |             2              2  2                                          |      7  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 7| 4| 6| 7| 7| 7|            |
                             DAY ON TEST   | 5| 2| 8| 3| 3| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 9| 2| 3| 1| 4| 3| 3| 3|            |
                                           | 7| 3| 0| 8| 8| 3| 4| 8| 8| 8| 8| 8| 8| 8| 8| 0| 0| 5| 5| 8| 4| 2| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     | 3  3  3                          3           2  2  4  3     4  4  3      |     17  3.0|
      Hyperplasia, Lymphoid                |       2     3           2                                2              2|      8  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Depletion Lymphoid                   | 2  2                                               2           2         |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Dilatation                           | 1     2  1        1  2        2        1  3     2  2              1     2|     19  1.7|
      Hyperplasia, Cystic                  |                                                                          |      1  2.0|
      Inflammation                         |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |          1     4                                                         |      5  1.8|
      Ulcer                                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   3        |
      Necrosis, Multifocal                 |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                          4               |      1  4.0|
      Hemorrhage, Focal                    |                                                             2            |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                         1|      1  1.0|
                                            __________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           | 1                                               3                        |      2  2.0|
      Hyperplasia, Lymphoid                | 1     1  1  1  1  1  2  1     1     1     1                    2        2|     22  1.3|
      Hyperplasia, Macrophage              |                                                 3                        |      1  3.0|
      Infiltration Cellular, Mixed Cell    |                                                    2  2                  |      2  2.0|
      Inflammation, Suppurative            |    2                                                                     |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                 2                        |      1  2.0|
      Mediastinum, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
      Mediastinum, Inflammation,           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 7| 4| 6| 7| 7| 7|            |
                             DAY ON TEST   | 5| 2| 8| 3| 3| 1| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 9| 2| 3| 1| 4| 3| 3| 3|            |
                                           | 7| 3| 0| 8| 8| 3| 4| 8| 8| 8| 8| 8| 8| 8| 8| 0| 0| 5| 5| 8| 4| 2| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
          Suppurative                      | 2                                                  3  3                  |      3  2.7|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumen, Exudate                       |             2  2  3     2  2     2  3  1                 1           1   |     23  1.7|
      Lumen, Foreign Body                  |       2  1  2  2  3     2  2     2  2  1        2  2  1  1           1   |     27  1.7|
      Mucosa, Cyst                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Artery, Peritracheal Tissue,         |                                                                          |            |
          Inflammation, Chronic            |                                                                   1      |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +                                                               |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                    3                     |      1  3.0|
      Fibrosis                             |       1                                            3                     |      2  2.0|
      Infiltration Cellular, Mixed Cell    |       2                                                                  |      1  2.0|
      Metaplasia, Osseous                  |                                                       1                  |      1  1.0|
      Mineralization                       |                                                                2         |      2  1.5|
      Nephropathy                          |                            2     1  2     1  1     3  1        1         |     16  1.5|
      Capsule, Fibrosis, Focal             |                                                                          |      1  2.0|
      Renal Tubule, Degeneration, Hyaline  |                                                                          |      1  3.0|
      Renal Tubule, Dilatation             |                                                                          |      2  2.0|
      Renal Tubule, Pigmentation           |                                              3                           |      1  3.0|
      Renal Tubule, Epithelium, Depletion  |                                                                          |            |
          Cellular                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |                   1           1                                          |      3  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 5| 5| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 6| 7| 4| 5| 6| 7| 7|             
                             DAY ON TEST   | 0| 7| 1| 2| 2| 1| 4| 6| 3| 3| 7| 5| 1| 1| 1| 1| 5| 5| 8| 0| 7| 4| 9| 1| 1|             
                                           | 1| 6| 5| 3| 5| 7| 1| 2| 1| 3| 7| 9| 6| 7| 7| 4| 2| 2| 5| 1| 5| 2| 5| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    15 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Perforation                          |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +  +  +  +  M  +  +  +  +  A  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |       4                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                         2|             
      Mucosa, Hyperplasia, Adenomatous     |                                                                          |             
      Mucosa, Ulcer                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      4                                                   |             
      Clear Cell Focus                     |                                                                          |             
      Cyst                                 |       3                                                                  |             
      Eosinophilic Focus                   |                                                    2                     |             
      Granuloma                            |                                                                          |             
      Hematopoietic Cell Proliferation     |             2                                                            |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                | 2  2  1  2  1     2  1  1  2        1  1  1  1  1     1  1  1  1  1     1|             
      Hyperplasia, Multifocal              | 3  3  3  3  3  3  3  3  3  3  3  2  3  3  3  3  3  2  3  3  2  2  3  3  3|             
      Infarct                              |       4              2  4     4        4     4        2     4            |             
      Infiltration Cellular, Mixed Cell    | 2     2  2  2  3  2              1  2  2  2     2     2     2     2     2|             
      Mineralization                       |                         3                                                |             
      Mixed Cell Focus                     |                                                                2         |             
      Necrosis, Multifocal                 |                                                                          |             
      Thrombosis                           |                               3                                          |             
      Vacuolization Cytoplasmic            | 2     2  2  2              2     2  2  2  2  1  2        2     2  2  2  2|             
      Bile Duct, Dilatation                |          3              2                 4                              |             
      Biliary Tract, Fibrosis              | 3  3  3  3  3  2  2  2  3  2  2  2  2  2  2  2  2  2  2  2  2  2  3  2  2|             
      Biliary Tract, Granuloma             |                                                                          |             
      Biliary Tract, Hyperplasia           | 3  3  3  3  3  2  2  2  3  2  3  2  2  2  2  2  2  2  2  2  2  2  3  2  2|             
      Biliary Tract, Inflammation, Chronic | 2  2  2  2  2  2  2  2  2  2  2  1  2  2  2  1  2  2  2  2  2  2  2  2  2|             
      Hepatocyte, Cytomegaly               | 2  2  2  2  2  2  2  2  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  2  2|             
      Hepatocyte, Degeneration             | 2  2  2  2  2  2  2  2  2  2  2     2  2  2  2  2  2  2  2  2  1  2  2  2|             
      Hepatocyte, Necrosis                 | 2  2  2  1  2  1  2  1  2  2  4  1  1     1  1  1  2  2  2  3  1  1  1  2|             
      Kupffer Cell, Pigmentation           | 3  2  2  2  2  2  2  2  3  1  2  1  2  2  2  2  2  2  1  2  1  2  2  2  2|             
      Parenchyma, Atrophy, Multifocal      | 3  3  3  3  3  2  3  3  3  3  3  2  3  3  3  3  3  2  3  3  3  2  3  3  3|             
                                            __________________________________________________________________________|             
   Mesentery                               | +              +                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 5| 5| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 6| 7| 4| 5| 6| 7| 7|             
                             DAY ON TEST   | 0| 7| 1| 2| 2| 1| 4| 6| 3| 3| 7| 5| 1| 1| 1| 1| 5| 5| 8| 0| 7| 4| 9| 1| 1|             
                                           | 1| 6| 5| 3| 5| 7| 1| 2| 1| 3| 7| 9| 6| 7| 7| 4| 2| 2| 5| 1| 5| 2| 5| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    15 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            | 3              3                                                         |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                          |             
      Fibrosis, Focal                      |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Hypoplasia                   |                            4                                             |             
      Artery, Inflammation, Chronic        |                                  4                                       |             
      Duct, Cyst                           |                            4                                             |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Focal                  |                1           2  1     2        1        1              2   |             
      Ulcer                                |                                                                          |             
      Mucosa, Cyst                         |                                                                          |             
      Mucosa, Erosion                      |                            2                                             |             
      Mucosa, Hyperplasia, Papillary       |                            2  1     2        1        1              2   |             
      Mucosa, Ulcer                        |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Degeneration, Hyaline    |                                                                         2|             
      Mucosa, Cyst                         |                1           2  2           1                       2     2|             
      Mucosa, Dysplasia, Focal             |                                                                          |             
      Mucosa, Erosion                      |       1                                                                 2|             
      Mucosa, Hemorrhage                   |                                                                         2|             
      Mucosa, Hyperplasia                  |                            2  2                                         2|             
      Mucosa, Mineralization               |                                                          2               |             
      Mucosa, Necrosis, Focal              |                                                                   1      |             
      Mucosa, Necrosis, Multifocal         |                                                                          |             
      Mucosa, Pigmentation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +              +                                                      |             
      Incisor, Dysplasia                   | 1  1              1                                                      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |             +                    +                                       |             
      Abdominal, Inflammation, Chronic     |             2                                                            |             
      Mesenteric Artery, Inflammation,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 5| 5| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 6| 7| 4| 5| 6| 7| 7|             
                             DAY ON TEST   | 0| 7| 1| 2| 2| 1| 4| 6| 3| 3| 7| 5| 1| 1| 1| 1| 5| 5| 8| 0| 7| 4| 9| 1| 1|             
                                           | 1| 6| 5| 3| 5| 7| 1| 2| 1| 3| 7| 9| 6| 7| 7| 4| 2| 2| 5| 1| 5| 2| 5| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    15 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
           Chronic                         |                                  3                                       |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic        |                                                                          |             
      Atrium, Thrombosis                   |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |             3        4     1                                      4  1  3|             
      Hyperplasia                          |                                           3                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                           2                              |             
      Pars Distalis, Cyst                  |                                                                3         |             
      Pars Distalis, Hyperplasia, Focal    |          1                    2        2           1                     |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                     2  1                       1        3|             
      Follicular Cell, Hyperplasia         |             2                    2                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                            4                                             |             
      Ectopic Tissue                       |                                                                          |             
      Fibrosis                             |                                     3                                    |             
      Inflammation, Suppurative            | 4              4                                                         |             
      Mineralization                       |                                                 3                        |             
      Pigmentation                         |                                     3                                    |             
      Artery, Inflammation, Chronic        |                                                                          |             
      Corpus Luteum, Degeneration          |                                     3                                    |             
      Corpus Luteum, Granuloma             |                                     3                                    |             
      Follicle, Cyst                       |    3  3     2     1     3     3     3     3              4  4     3      |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
      Ectopic Tissue                       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 5| 5| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 6| 7| 4| 5| 6| 7| 7|             
                             DAY ON TEST   | 0| 7| 1| 2| 2| 1| 4| 6| 3| 3| 7| 5| 1| 1| 1| 1| 5| 5| 8| 0| 7| 4| 9| 1| 1|             
                                           | 1| 6| 5| 3| 5| 7| 1| 2| 1| 3| 7| 9| 6| 7| 7| 4| 2| 2| 5| 1| 5| 2| 5| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    15 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Angiectasis                          |          4                                                              2|             
      Hydrometra                           |                      1                          2                        |             
      Inflammation, Suppurative            | 3              2  2                                                      |             
      Endometrium, Hyperplasia, Cystic     | 3  3  3        3  2  3  2  3  3     3  3  3  3  3     2     3  3  1  2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Renal, Hyperplasia                   | 3                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  M  +  M  M  M  M  +  M  M  +  M  +  M  +  +  +  +  M  +  M  +  M|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia                          |                                        2              2                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +|             
      Angiectasis                          | 2                                                                        |             
      Hyperplasia, Lymphoid                |             2                                                            |             
      Hyperplasia                          |                               2                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Artery, Inflammation, Chronic        |                                  3                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             3                                                            |             
      Hematopoietic Cell Proliferation     |             2                                                            |             
      Hyperplasia, Lymphoid                |                               2                 2                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 3  2  3  3  3     3     3  2        3  3  3     2  3  3  4        3     3|             
      Hyperplasia, Lymphoid                |                                                 3                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +|             
      Depletion Lymphoid                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                      2        2  2              2     2  2     2         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                    2                     |             
      Ulcer                                |                                                    2                     |             
      Subcutaneous Tissue, Hemorrhage      |                                                                          |             
      Subcutaneous Tissue, Hyperplasia,    |                                                                          |             
           Lymphoid                        |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Suppurative                     |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Fracture                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 5| 5| 7| 7| 5| 6| 7| 7| 7| 5| 6| 6| 6| 7| 4| 5| 6| 7| 7|             
                             DAY ON TEST   | 0| 7| 1| 2| 2| 1| 4| 6| 3| 3| 7| 5| 1| 1| 1| 1| 5| 5| 8| 0| 7| 4| 9| 1| 1|             
                                           | 1| 6| 5| 3| 5| 7| 1| 2| 1| 3| 7| 9| 6| 7| 7| 4| 2| 2| 5| 1| 5| 2| 5| 7| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    15 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                  2  2                                    |             
      Hyperplasia, Lymphoid                | 1  1     2  1     1  3  1  2  2  1  2  1     1  1     1        1     1  1|             
      Hyperplasia, Macrophage              |                                  2                                       |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Mediastinum, Foreign Body            |                                                                          |             
      Mediastinum, Hemorrhage              |                                                                          |             
      Mediastinum, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinum, Inflammation,           |                                                                          |             
          Suppurative                      |                                                                          |             
      Pleura, Fibrosis                     |                                                                          |             
      Pleura, Inflammation, Suppurative    |                3                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Exudate                       |             3                                2              2  3        2|             
      Lumen, Foreign Body                  |       2  2  2                       2        1           2  1  3  2     2|             
      Lumen, Hemorrhage                    |                                                                          |             
      Lumen, Inflammation, Suppurative     |                                     2                                    |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |       2                                         3                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                                            +  +                 +|             
      Acinus, Dilatation                   |       1                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
      Mineralization                       |                               1     1                                    |             
      Nephropathy                          |       3     3     1     1  1     4     1  2  1           1              1|             
      Artery, Inflammation, Chronic        |                                  2                                       |             
      Interstitial Tissue, Pigmentation    |                                                                          |             
      Renal Tubule, Casts                  |                               3                                          |             
      Renal Tubule, Dilatation             |                               3                                1         |             
      Renal Tubule, Necrosis               |                               3                       4                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 6| 7| 7| 4| 5| 5| 5| 7| 5| 5| 6| 6| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 6| 3| 6| 3| 3| 5| 4| 7| 8| 1| 4| 8| 2| 5| 2| 1| 2| 2| 0| 2| 4| 0| 1| 1| 1|            |
                                           | 0| 2| 8| 6| 6| 6| 9| 0| 6| 9| 0| 6| 1| 9| 4| 3| 1| 5| 1| 4| 2| 9| 2| 6| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    15 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Perforation                          |                                                    4                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M|  43        |
      Infarct                              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic                |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | A  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Congestion                           |                                                                          |      1  2.0|
      Mucosa, Hyperplasia, Adenomatous     |    3                                                                     |      1  3.0|
      Mucosa, Ulcer                        |    1                                                                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |    3        4                                                            |      3  3.7|
      Clear Cell Focus                     |          2                                                               |      1  2.0|
      Cyst                                 |                                                                          |      1  3.0|
      Eosinophilic Focus                   |                                                                          |      1  2.0|
      Granuloma                            |                                                                   3      |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                      3   |      2  2.5|
      Hemorrhage                           |                                                                   2      |      1  2.0|
      Hyperplasia, Lymphoid                | 1  1  1  1  1  1  1  2  1  1  1  1  1     2  1     1  1  2  1  1  1  2   |     42  1.2|
      Hyperplasia, Multifocal              |    3     3  3  2  3  3  3  3  3  3  4  2  3  3  3  3  3  3  3  4  3  3  3|     48  2.9|
      Infarct                              |                   4                 4                       3            |     11  3.5|
      Infiltration Cellular, Mixed Cell    | 1  2  2     2  2  2  2  1  2  2  3  1  2           2     2  2     2      |     32  1.9|
      Mineralization                       |                                                                   2      |      2  2.5|
      Mixed Cell Focus                     |       3                             3                                    |      3  2.7|
      Necrosis, Multifocal                 | 1           3     2                                                      |      3  2.0|
      Thrombosis                           |             3                                                     3      |      3  3.0|
      Vacuolization Cytoplasmic            |       2  2  2  1  2     2  2     2  1  2  2  2     2  2  2  2  2  2  2  2|     36  1.9|
      Bile Duct, Dilatation                |       1  3        3        4              2           2  3           3   |     11  2.7|
      Biliary Tract, Fibrosis              | 2  2  3  3  3  1  2  3  2  2  2  2  2  2  3  3  2  2  2  2  2  3  2  2  2|     50  2.3|
      Biliary Tract, Granuloma             |                                                    3                     |      1  3.0|
      Biliary Tract, Hyperplasia           | 2  2  3  3  2  1  2  3  2  3  2  2  2  2  3  2  3  2  2  2  2  3  2  2  2|     50  2.3|
      Biliary Tract, Inflammation, Chronic | 2  2  2  2  2  1  2  2  2  2  2  2  2  2  2  3  2  2  2  2  2  2  2  2  2|     50  2.0|
      Hepatocyte, Cytomegaly               | 1  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|     50  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 6| 7| 7| 4| 5| 5| 5| 7| 5| 5| 6| 6| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 6| 3| 6| 3| 3| 5| 4| 7| 8| 1| 4| 8| 2| 5| 2| 1| 2| 2| 0| 2| 4| 0| 1| 1| 1|            |
                                           | 0| 2| 8| 6| 6| 6| 9| 0| 6| 9| 0| 6| 1| 9| 4| 3| 1| 5| 1| 4| 2| 9| 2| 6| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    15 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hepatocyte, Degeneration             |    2  2  2  2  1  2  2  2  3  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|     48  2.0|
      Hepatocyte, Necrosis                 |    1  1  1  3  1  2  1  2  1  1  2     1  1  1  2  2  2  2  1  1  2  1  1|     47  1.6|
      Kupffer Cell, Pigmentation           | 1  2  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  3  2  2  2  2  3  2  2|     50  2.0|
      Parenchyma, Atrophy, Multifocal      | 3  2  3  3  3  1  2  2  3  3  2  3  3  2  3  3  3  3  3  3  2  3  3  2  3|     50  2.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +        +                                                   |   4        |
      Inflammation, Chronic                |             1                                                            |      1  1.0|
      Inflammation, Suppurative            |                      4                                                   |      3  3.3|
      Fat, Necrosis                        |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy, Focal                       |                               2              3                           |      2  2.5|
      Fibrosis, Focal                      |                                           2                              |      1  2.0|
      Inflammation, Chronic                |                               2                                          |      1  2.0|
      Acinus, Hypoplasia                   |                                                                          |      1  4.0|
      Artery, Inflammation, Chronic        |                                  4                                       |      2  4.0|
      Duct, Cyst                           |                                              3                           |      2  3.5|
      Duct, Dilatation                     |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Erosion                              |                            2                                             |      1  2.0|
      Hyperplasia                          |                               2     2                                    |      2  2.0|
      Hyperplasia, Squamous                |                            2                                3            |      2  2.5|
      Inflammation, Focal                  |                   2                                2                     |      9  1.6|
      Ulcer                                |                                                             2            |      1  2.0|
      Mucosa, Cyst                         |                                                                      2   |      1  2.0|
      Mucosa, Erosion                      |                                                                          |      1  2.0|
      Mucosa, Hyperplasia, Papillary       |                   1                                2                     |      8  1.5|
      Mucosa, Ulcer                        |                   2           2                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Epithelium, Degeneration, Hyaline    |          2                                                               |      2  2.0|
      Mucosa, Cyst                         |       1  2                       2        2                              |     10  1.7|
      Mucosa, Dysplasia, Focal             |                                           1                              |      1  1.0|
      Mucosa, Erosion                      |                                                                          |      2  1.5|
      Mucosa, Hemorrhage                   |          2                                                               |      2  2.0|
      Mucosa, Hyperplasia                  |                                                                          |      3  2.0|
      Mucosa, Mineralization               |                               2                                          |      2  2.0|
      Mucosa, Necrosis, Focal              |                                                                          |      1  1.0|
      Mucosa, Necrosis, Multifocal         |                2                                                         |      1  2.0|
      Mucosa, Pigmentation                 |                2                                                         |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 6| 7| 7| 4| 5| 5| 5| 7| 5| 5| 6| 6| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 6| 3| 6| 3| 3| 5| 4| 7| 8| 1| 4| 8| 2| 5| 2| 1| 2| 2| 0| 2| 4| 0| 1| 1| 1|            |
                                           | 0| 2| 8| 6| 6| 6| 9| 0| 6| 9| 0| 6| 1| 9| 4| 3| 1| 5| 1| 4| 2| 9| 2| 6| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    15 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                    +                     |   1        |
      Hemorrhage                           |                                                    4                     |      1  4.0|
      Necrosis                             |                                                    4                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   3        |
      Incisor, Dysplasia                   |                                                                          |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |       +                                                                  |   3        |
      Abdominal, Inflammation, Chronic     |                                                                          |      1  2.0|
      Mesenteric Artery, Inflammation,     |                                                                          |            |
           Chronic                         |       4                                                                  |      2  3.5|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Artery, Inflammation, Chronic        |       3                                                                  |      1  3.0|
      Atrium, Thrombosis                   |    3                                                                     |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                      2                                                   |      1  2.0|
      Hyperplasia, Focal                   |                                           1                              |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                    3  1                  |      8  2.5|
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | I  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  46        |
      Pars Distalis, Angiectasis           |          2                          3                                3   |      4  2.5|
      Pars Distalis, Cyst                  |                            2                                             |      2  2.5|
      Pars Distalis, Hyperplasia, Focal    |       2                                                                  |      5  1.6|
      Pars Distalis, Hyperplasia           |                                                                2         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |       1                                               1  1               |      7  1.4|
      Follicular Cell, Hyperplasia         |          1                 1           2                    1        3  2|      8  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                   +                                                      |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 6| 7| 7| 4| 5| 5| 5| 7| 5| 5| 6| 6| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 6| 3| 6| 3| 3| 5| 4| 7| 8| 1| 4| 8| 2| 5| 2| 1| 2| 2| 0| 2| 4| 0| 1| 1| 1|            |
                                           | 0| 2| 8| 6| 6| 6| 9| 0| 6| 9| 0| 6| 1| 9| 4| 3| 1| 5| 1| 4| 2| 9| 2| 6| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    15 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                   4                                                      |      1  4.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1  4.0|
      Ectopic Tissue                       | 4                                                                        |      1  4.0|
      Fibrosis                             |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                      4                                                   |      3  4.0|
      Mineralization                       |                                                                          |      1  3.0|
      Pigmentation                         |                                                                          |      1  3.0|
      Artery, Inflammation, Chronic        |    3                                                                     |      1  3.0|
      Corpus Luteum, Degeneration          |                                                                          |      1  3.0|
      Corpus Luteum, Granuloma             |                                                                          |      1  3.0|
      Follicle, Cyst                       | 4     3  3           4     3                          3     2     3  4  2|     21  3.0|
                                            __________________________________________________________________________|____________|
   Oviduct                                 | +                                                                        |   1        |
      Ectopic Tissue                       | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                             3            |      3  3.0|
      Hydrometra                           |             3        1        2  1                             4         |      7  2.0|
      Inflammation, Suppurative            |                      4                                   1               |      5  2.4|
      Endometrium, Hyperplasia, Cystic     | 2     3  3  2  2  3  3  3  3  3  3  2  3  3  3  2  4  2  3  4  2     2  2|     42  2.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Renal, Hyperplasia                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  M  +  M  +  M  M  +  M  +  M  M  +  M  M  +  +  M  M  M  M  M  M  +  M|  21        |
      Hyperplasia                          |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                  2                                       |      3  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  M  +  +  M  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  M  +  +  +|  43        |
      Angiectasis                          |                                                                   3      |      2  2.5|
      Hyperplasia, Lymphoid                |                                                 2                        |      2  2.0|
      Hyperplasia                          |                      3                                                   |      2  2.5|
      Inflammation, Suppurative            |                      3                                                   |      1  3.0|
      Artery, Inflammation, Chronic        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                         2     2                 2                        |      5  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 6| 7| 7| 4| 5| 5| 5| 7| 5| 5| 6| 6| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 6| 3| 6| 3| 3| 5| 4| 7| 8| 1| 4| 8| 2| 5| 2| 1| 2| 2| 0| 2| 4| 0| 1| 1| 1|            |
                                           | 0| 2| 8| 6| 6| 6| 9| 0| 6| 9| 0| 6| 1| 9| 4| 3| 1| 5| 1| 4| 2| 9| 2| 6| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    15 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     |    2  3     2        3     3  3  3  2  3  3     3  3  3  3  3     2  3   |     34  2.8|
      Hyperplasia, Lymphoid                |                               2           2           2  2  2  3         |      7  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +|  45        |
      Depletion Lymphoid                   |                                     3                                    |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Dilatation                           | 2     2  2        2     2        2        2     2              2     3  2|     18  2.1|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                1                                                         |      2  1.5|
      Ulcer                                |                                                                          |      1  2.0|
      Subcutaneous Tissue, Hemorrhage      |       3                                            4                     |      2  3.5|
      Subcutaneous Tissue, Hyperplasia,    |                                                                          |            |
           Lymphoid                        |                         2                                                |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Suppurative                     |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Femur, Fracture                      |       4                                                                  |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |    3                                                              2      |      4  2.3|
      Hyperplasia, Lymphoid                |          2  1  2           2  1           2  1           1     1  1      |     28  1.4|
      Hyperplasia, Macrophage              |                                           2                              |      2  2.0|
      Infiltration Cellular, Mixed Cell    | 2                                   2                                    |      2  2.0|
      Mediastinum, Foreign Body            |                                                    4                     |      1  4.0|
      Mediastinum, Hemorrhage              |       4                                                                  |      1  4.0|
      Mediastinum, Hyperplasia, Lymphoid   |                         2        2                                       |      2  2.0|
      Mediastinum, Inflammation,           |                                                                          |            |
          Suppurative                      |                                                    4                     |      1  4.0|
      Pleura, Fibrosis                     |                                                    3                     |      1  3.0|
      Pleura, Inflammation, Suppurative    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 6| 6| 7| 7| 4| 5| 5| 5| 7| 5| 5| 6| 6| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 6| 3| 6| 3| 3| 5| 4| 7| 8| 1| 4| 8| 2| 5| 2| 1| 2| 2| 0| 2| 4| 0| 1| 1| 1|            |
                                           | 0| 2| 8| 6| 6| 6| 9| 0| 6| 9| 0| 6| 1| 9| 4| 3| 1| 5| 1| 4| 2| 9| 2| 6| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    15 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Lumen, Exudate                       |    2  2     3                          2  2  3  1  1  3  2  1  1  1  3  3|     20  2.1|
      Lumen, Foreign Body                  |    2  2  2  2              2        1  2  2        2  3  2  1  2  1  3  3|     26  2.0|
      Lumen, Hemorrhage                    |          2                                                               |      1  2.0|
      Lumen, Inflammation, Suppurative     |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   4        |
      Acinus, Dilatation                   |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hydronephrosis                       |    2                                                                     |      1  2.0|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                     2                                    |      1  2.0|
      Mineralization                       |                   2                 3                                    |      4  1.8|
      Nephropathy                          |    4                       2  1  1        2     2  2  1     1     2  2   |     22  1.8|
      Artery, Inflammation, Chronic        |       3                                                                  |      2  2.5|
      Interstitial Tissue, Pigmentation    |       2                                                           2      |      2  2.0|
      Renal Tubule, Casts                  |                                                                          |      1  3.0|
      Renal Tubule, Dilatation             |                   2     1                                                |      4  1.8|
      Renal Tubule, Necrosis               |                   1                 2                                    |      4  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |                      3                                                   |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 4| 4| 1| 3| 3| 0| 1| 3| 3| 3| 9| 3| 4| 3| 3|             
                                           | 1| 6| 6| 6| 6| 5| 7| 7| 7| 7| 2| 2| 5| 3| 7| 3| 7| 7| 7| 7| 2| 8| 6| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    8 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Inflammation, Chronic                |                3                                                         |             
      Mucosa, Ulcer                        |                2                                                         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Mucosa, Amyloid Deposition           |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                            3                                             |             
      Basophilic Focus                     |       2                                                                  |             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                       2                  |             
      Eosinophilic Focus                   |                            2                                             |             
      Hematopoietic Cell Proliferation     |                                  4           3              3            |             
      Hemorrhage                           | 3                                                                        |             
      Hyperplasia, Lymphoid                | 1        2  1  2     2  2  2  1                       1  1  1  2     1   |             
      Hyperplasia, Multifocal              | 2  2  2  2  3  2  2  2  2  2  2  1  2  2  2  2  2  2  2  2  3  2  2  2  2|             
      Infarct                              |       4                                         3                    4   |             
      Infiltration Cellular, Mixed Cell    | 2  2  2  2  2           2  2     2           2              3  2         |             
      Inflammation, Multifocal             |             2        2  2  2                                         2   |             
      Mineralization                       |             2                                                            |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Multifocal                 |                                                                      2   |             
      Vacuolization Cytoplasmic            | 2        1        2  1        3  2  3  1     1     1     1        1     1|             
      Bile Duct, Dilatation                |                            3                                             |             
      Biliary Tract, Fibrosis              |    1  3  2  3  2  2  1  2  2  1  1  1  1  2  3  1  1  1  1  2  2  1  2  1|             
      Biliary Tract, Hyperplasia           |    1  2  2  3  2  2  1  1  2  1  1  1  1  2  1  1  1  1  1  2  1  1  1  1|             
      Biliary Tract, Inflammation, Chronic | 1  1  2  1  2  2  2  1  2  2  1  1  1  1  2  2  1  1  1  1  2  2  1  1  1|             
      Hepatocyte, Cytomegaly               | 2  2  2  2  2  2  2  2  2  2  2  1  2  2  2  2  2  2  2  2     2  2  2  2|             
      Hepatocyte, Degeneration             | 2  1  2  2  2  2  2  2  2  2  2  2  3  1  2  2  2  2  2  2     2  2  2  2|             
      Hepatocyte, Necrosis                 | 1  1  2  1  2  1  1  1  2  1  1     1     1  2  2  1  1  1     1  1  3  1|             
      Kupffer Cell, Pigmentation           | 1  1  2  1  3  2  2  1  2  2  1  1  1  1  2  2  1  1  1  1  3  2  2  2  1|             
      Parenchyma, Atrophy, Focal           |                                                             3            |             
      Parenchyma, Atrophy, Multifocal      |    2  2  2  3  3  3  1  1  2  2  1  2  2  2  3  2  1  2  2     2  2  2  2|             
                                            __________________________________________________________________________|             
   Mesentery                               |       +  +     +           +     +  +  +  +  +  +  +        +            |             
      Inflammation, Chronic                |                                  3                                       |             
      Inflammation, Suppurative            |                                                             4            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 4| 4| 1| 3| 3| 0| 1| 3| 3| 3| 9| 3| 4| 3| 3|             
                                           | 1| 6| 6| 6| 6| 5| 7| 7| 7| 7| 2| 2| 5| 3| 7| 3| 7| 7| 7| 7| 2| 8| 6| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    8 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Fat, Necrosis                        |          3     3           1     3           3                           |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic                |                                  3                                       |             
      Acinar Cell, Hyperplasia             |          2                                                               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hyperplasia, Papillary               |                                     3                                    |             
      Inflammation, Focal                  |    1                          1                          1               |             
      Mucosa, Erosion                      |    2                                                                     |             
      Mucosa, Hyperplasia, Papillary       |    1  1                       1        1              2  1               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                      2   |             
      Mineralization                       |                                                                          |             
      Epithelium, Degeneration, Hyaline    |                                        2        2                        |             
      Epithelium, Metaplasia, Squamous     |                                                 2                        |             
      Epithelium, Vacuolization            |                                                                          |             
          Cytoplasmic, Multifocal          |                                                                          |             
      Mucosa, Cyst                         |          2                       2           1     2     1               |             
      Mucosa, Erosion                      |                                                 1                        |             
      Mucosa, Hyperplasia                  |                                                 2                    2   |             
      Mucosa, Mineralization               |                                                                          |             
      Serosa, Inflammation, Chronic        |                                  2                                       |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Angiectasis                          |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                          +               |             
      Incisor, Dysplasia                   |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Mesenteric Artery, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
      Pulmonary Artery, Inflammation,      |                                                                          |             
          Chronic                          |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium, Inflammation, Chronic        |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 4| 4| 1| 3| 3| 0| 1| 3| 3| 3| 9| 3| 4| 3| 3|             
                                           | 1| 6| 6| 6| 6| 5| 7| 7| 7| 7| 2| 2| 5| 3| 7| 3| 7| 7| 7| 7| 2| 8| 6| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    8 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Accessory Adrenal Cortical Nodule    |          2                                                               |             
      Cytologic Alterations, Focal         |          1                                                               |             
      Developmental Malformation           |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                                      2   |             
      Extra Adrenal Tissue, Accessory      |                                                                          |             
          Adrenal Cortical Nodule          |                                                                      1  1|             
      Subcapsular, Hyperplasia, Focal      |                                                                         2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                                                1         |             
      Hyperplasia, Focal                   |                                                                1         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                  2                                       |             
      Pars Distalis, Cyst                  |                                                          1               |             
      Pars Distalis, Focal Cellular Change |                                                          1               |             
      Pars Distalis, Hyperplasia, Focal    |                            1  1  2              1              1        2|             
      Pars Intermedia, Vacuolization       |                                                                          |             
          Cytoplasmic                      |                                     2                                    |             
      Pars Nervosa, Hyperplasia, Focal     |                                                                      2   |             
      Rathke's Cleft, Hemorrhage           |                                                                      3   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |    1           1                             2                 1         |             
      Follicle, Cyst                       |                               3                                          |             
      Follicular Cell, Hyperplasia         | 1           2        2  1     2        1              1                 1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                          2               |             
      Inflammation, Chronic                |                                                                      3   |             
      Inflammation, Suppurative            |                      3                       4              4           4|             
      Corpus Luteum, Degeneration          |                                                                      3   |             
      Corpus Luteum, Granuloma             |                                                                      3   |             
      Follicle, Cyst                       |       2  2           4                             2  1  1     2     3  1|             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                         +|             
      Inflammation, Suppurative            |                                                                         4|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hydrometra                           |       2     2        2              3                                    |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 4| 4| 1| 3| 3| 0| 1| 3| 3| 3| 9| 3| 4| 3| 3|             
                                           | 1| 6| 6| 6| 6| 5| 7| 7| 7| 7| 2| 2| 5| 3| 7| 3| 7| 7| 7| 7| 2| 8| 6| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    8 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                   2  2                       3        2  2  3            |             
      Endometrium, Hyperplasia, Cystic     | 3  3  3  3  3  3  3  3  4  3  3  3  2  3  3  4  1  3  3  4  3  3  3  3  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                         3                                                |             
      Hyperplasia                          |                                                                          |             
      Hyperplasia, Neutrophil              |                                                                          |             
      Myelofibrosis                        |                         3                                                |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Hyperplasia                   |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Inguinal, Hyperplasia                |                                                                          |             
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                3                                                         |             
      Pancreatic, Inflammation, Suppurative|                                                                          |             
      Popliteal, Hyperplasia, Lymphoid     |                                                                          |             
      Renal, Hyperplasia                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  +  +  M  +  M  M  M  +  M  +  +  +  +  M  +  +  +  +  M  +  +  +  +|             
      Hyperplasia, Lymphoid                |          1                 2                                             |             
      Hyperplasia                          | 2                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                3         |             
      Hyperplasia, Lymphoid                |                                                                2         |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |             3                                                            |             
      Hyperplasia                          |                                                             3            |             
      Inflammation, Suppurative            |                                                             3            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia, Lymphoid                |                                              2        2                  |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                3        3        4           4              3  3         |             
      Hyperplasia, Lymphoid                |          2           2     2                             1           2  2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Depletion Lymphoid                   |                                                                          |             
      Hyperplasia, Lymphoid                |                            2                                             |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 4| 4| 1| 3| 3| 0| 1| 3| 3| 3| 9| 3| 4| 3| 3|             
                                           | 1| 6| 6| 6| 6| 5| 7| 7| 7| 7| 2| 2| 5| 3| 7| 3| 7| 7| 7| 7| 2| 8| 6| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    8 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 3     3     3                 1  2  2     2                       2      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                1                                1     2                 1|             
      Ulcer                                |                                                                          |             
      Subcutaneous Tissue, Infiltration    |                                                                          |             
          Cellular, Mixed Cell             |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Suppurative                     |                                  3                                       |             
      Subcutaneous Tissue, Fat, Necrosis   |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Distal, Joint, Femur, Arthrosis      |                                        2                                 |             
      Trabecula, Cranium, Hyperostosis     |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                             +            |             
      Hindlimb, Inflammation, Suppurative  |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |          2  2        2  2  2  2              1        2  1     1     1  2|             
      Hyperplasia, Macrophage              |                         1                                                |             
      Infiltration Cellular, Mixed Cell    |                                              2                 2         |             
      Inflammation, Suppurative            |                                                             3            |             
      Fat, Mediastinum, Necrosis           |                                  2                                       |             
      Mediastinum, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinum, Inflammation,           |                                                                          |             
          Suppurative                      |                                                             3            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Exudate                       | 1        2  2        2     2  2              2        1                 1|             
      Lumen, Foreign Body                  |       1  2  2  2     1     2  2           1  2  2  1  1                 1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |       +                                                                  |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                                             |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                       +                                         +   |             
      Acinus, Dilatation                   |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 4| 4| 1| 3| 3| 0| 1| 3| 3| 3| 9| 3| 4| 3| 3|             
                                           | 1| 6| 6| 6| 6| 5| 7| 7| 7| 7| 2| 2| 5| 3| 7| 3| 7| 7| 7| 7| 2| 8| 6| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    8 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Fibrosis                             |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |       2                       2                                          |             
      Nephropathy                          | 1  2  2        2        2        1                          1        1   |             
      Renal Tubule, Bacterium              |                                                                          |             
      Renal Tubule, Degeneration, Hyaline  |                                                                          |             
      Renal Tubule, Dilatation             |                                                             2            |             
      Renal Tubule, Pigmentation           |                2                                                         |             
      Renal Tubule, Vacuolization          |                                                                          |             
          Cytoplasmic                      |                               2                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 3| 4| 6| 6| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 8| 0| 3| 3| 3| 4| 2| 9| 3| 7| 7| 3| 3| 3| 9| 2| 2| 3| 3| 0| 1| 3| 3| 3|            |
                                           | 6| 8| 1| 7| 7| 0| 6| 7| 5| 7| 9| 3| 7| 7| 7| 9| 4| 8| 7| 7| 2| 6| 7| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    8 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Edema                                |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  47        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Mucosa, Ulcer                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  47        |
      Mucosa, Amyloid Deposition           |                                  4                                       |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                    2                     |      2  2.5|
      Basophilic Focus                     |                                                                          |      1  2.0|
      Congestion                           |                                  4                                       |      1  4.0|
      Cyst                                 |                                                                          |      1  2.0|
      Eosinophilic Focus                   |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     | 3  2                 2  2     2                             2            |      9  2.6|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                | 1  1  1     1        1  2  2  1  2  1  2  2  2     1  2  2     2  1  1  1|     33  1.5|
      Hyperplasia, Multifocal              | 2  2  2  2  2     3  2  2  2  2  2  2  2  2  2     2  2  1  2  2  1  2  2|     48  2.0|
      Infarct                              |                         3        2           2  4                        |      7  3.1|
      Infiltration Cellular, Mixed Cell    | 3  2  1        3     3  2     2  2  1        2     1        1            |     23  2.0|
      Inflammation, Multifocal             |       1  1                          1  2              2  1        1     1|     13  1.5|
      Mineralization                       |                                                                          |      1  2.0|
      Mixed Cell Focus                     |       3     2                 3     3                                2   |      5  2.6|
      Necrosis, Multifocal                 |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |             1     3        1     1  1  1  1     2  1  1  1  2  1  1  1  1|     29  1.4|
      Bile Duct, Dilatation                |                                                                          |      1  3.0|
      Biliary Tract, Fibrosis              | 2  1  1  1  1     3  2  3  1  2  2  1  1  1  1     2  2  1  1  1  1  1  1|     47  1.5|
      Biliary Tract, Hyperplasia           | 2  1  1  1  1     2  1  2  1  2  1  1  1  1  1     1  2  1  1  1  1  1  1|     47  1.3|
      Biliary Tract, Inflammation, Chronic | 1  1  1  1  1     2  2  2  1  2  1  1  1  1  1     1  1  1  1  1  1  1  1|     48  1.3|
      Hepatocyte, Cytomegaly               | 2  2  2  2  2     2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  1  2  2|     48  2.0|
      Hepatocyte, Degeneration             | 2  2  2  2  2     2  2  2  2  2  3  2  2  1  2     2  2  2  2  2  2  2  2|     47  2.0|
      Hepatocyte, Necrosis                 | 1  1  1  1  1     2  1  1  1  1  3     1  1  1     1  2  1  2  1  1  1  1|     44  1.3|
      Kupffer Cell, Pigmentation           | 2  2  2  2  1     2  2  2  2  2  2  2  2  2  1     1  2  1  1  1  1  1  1|     48  1.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 3| 4| 6| 6| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 8| 0| 3| 3| 3| 4| 2| 9| 3| 7| 7| 3| 3| 3| 9| 2| 2| 3| 3| 0| 1| 3| 3| 3|            |
                                           | 6| 8| 1| 7| 7| 0| 6| 7| 5| 7| 9| 3| 7| 7| 7| 9| 4| 8| 7| 7| 2| 6| 7| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    8 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Parenchyma, Atrophy, Focal           |                                                                          |      1  3.0|
      Parenchyma, Atrophy, Multifocal      | 2  2  2  1  1     3  2  2  2  2  2  2  2  1  1  3  2  2  2  2  2  1  2  2|     47  1.9|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +     +     +  +  +  +  +  +     +        +  +        +  +  +         |  27        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Suppurative            | 4  4           3     4        3     4                                    |      7  3.7|
      Fat, Necrosis                        |                                                          3     3         |      7  2.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Lymphoid                |                                        2  1           1  1        1      |      5  1.2|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Acinar Cell, Hyperplasia             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |                                        2           2  2        1         |      4  1.8|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Edema                                |       3                                                                  |      1  3.0|
      Hyperplasia, Papillary               |                                                                          |      1  3.0|
      Inflammation, Focal                  |          1  2                                               1  2         |      7  1.3|
      Mucosa, Erosion                      |             1                                                            |      2  1.5|
      Mucosa, Hyperplasia, Papillary       |          1  2                                               1  2         |     10  1.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Edema                                |       3                                                                  |      1  3.0|
      Hyperplasia, Lymphoid                |                                                          2               |      2  2.0|
      Mineralization                       |                                        1  2                    1         |      3  1.3|
      Epithelium, Degeneration, Hyaline    |                                  2     2                 2               |      5  2.0|
      Epithelium, Metaplasia, Squamous     |                                                                          |      1  2.0|
      Epithelium, Vacuolization            |                                                                          |            |
          Cytoplasmic, Multifocal          |                               3                                          |      1  3.0|
      Mucosa, Cyst                         |          2              2              2     1           2        1     1|     12  1.6|
      Mucosa, Erosion                      |                                  1                                       |      2  1.0|
      Mucosa, Hyperplasia                  |                                        2                 2              1|      5  1.8|
      Mucosa, Mineralization               |       1                                                                  |      1  1.0|
      Serosa, Inflammation, Chronic        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |       +              +                                                   |   2        |
      Angiectasis                          |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Incisor, Dysplasia                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |    +                                                                    +|   2        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 3| 4| 6| 6| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 8| 0| 3| 3| 3| 4| 2| 9| 3| 7| 7| 3| 3| 3| 9| 2| 2| 3| 3| 0| 1| 3| 3| 3|            |
                                           | 6| 8| 1| 7| 7| 0| 6| 7| 5| 7| 9| 3| 7| 7| 7| 9| 4| 8| 7| 7| 2| 6| 7| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    8 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Mesenteric Artery, Inflammation,     |                                                                          |            |
           Chronic                         |    3                                                                     |      1  3.0|
      Pulmonary Artery, Inflammation,      |                                                                          |            |
          Chronic                          |                                                                         1|      1  1.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrium, Inflammation, Chronic        |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |          1                                                               |      2  1.5|
      Cytologic Alterations, Focal         |                                                                          |      1  1.0|
      Developmental Malformation           |                            1                                             |      1  1.0|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      1  2.0|
      Extra Adrenal Tissue, Accessory      |                                                                          |            |
          Adrenal Cortical Nodule          |                                                                          |      2  1.0|
      Subcapsular, Hyperplasia, Focal      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectopic Tissue                       |                                                                          |      1  1.0|
      Hyperplasia, Focal                   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Pars Distalis, Angiectasis           |                                           2                              |      2  2.0|
      Pars Distalis, Cyst                  |                                                                          |      1  1.0|
      Pars Distalis, Focal Cellular Change |                                                                          |      1  1.0|
      Pars Distalis, Hyperplasia, Focal    |                      1                    2                              |      8  1.4|
      Pars Intermedia, Vacuolization       |                                                                          |            |
          Cytoplasmic                      |                                                                          |      1  2.0|
      Pars Nervosa, Hyperplasia, Focal     |                                                                          |      1  2.0|
      Rathke's Cleft, Hemorrhage           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                                                                          |      4  1.3|
      Follicle, Cyst                       |                                                                          |      1  3.0|
      Follicular Cell, Hyperplasia         |                                           2        3  2                  |     11  1.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                   +                                                      |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 3| 4| 6| 6| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 8| 0| 3| 3| 3| 4| 2| 9| 3| 7| 7| 3| 3| 3| 9| 2| 2| 3| 3| 0| 1| 3| 3| 3|            |
                                           | 6| 8| 1| 7| 7| 0| 6| 7| 5| 7| 9| 3| 7| 7| 7| 9| 4| 8| 7| 7| 2| 6| 7| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    8 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |       2                                                                  |      2  2.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Suppurative            | 4  4           4     4  4     4                                          |     10  3.9|
      Corpus Luteum, Degeneration          |                                                                          |      1  3.0|
      Corpus Luteum, Granuloma             |                                                                          |      1  3.0|
      Follicle, Cyst                       |                            2        3     2  2        1              1   |     15  1.9|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                   +  +                       +                           |   4        |
      Inflammation, Suppurative            |                      4                                                   |      2  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                  2                                       |      1  2.0|
      Hydrometra                           |                                                       3        4        3|      7  2.7|
      Hyperplasia, Lymphoid                |             2                                                            |      1  2.0|
      Inflammation, Suppurative            | 3              3                 1                                       |      9  2.3|
      Endometrium, Hyperplasia, Cystic     | 3  3  3     2     3  2     3  3  4  3  3  4  3  3  3  4  3  3  3  3  4  4|     47  3.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Hyperplasia                          |    3                                                                     |      1  3.0|
      Hyperplasia, Neutrophil              |                                                             3            |      1  3.0|
      Myelofibrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Iliac, Hyperplasia                   |                         3                                                |      1  3.0|
      Inguinal, Hyperplasia, Lymphoid      |                            2                                            1|      2  1.5|
      Inguinal, Hyperplasia                | 2                             3                                          |      2  2.5|
      Lumbar, Hyperplasia, Lymphoid        |                                                    2                     |      1  2.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  3.0|
      Pancreatic, Inflammation, Suppurative|                                              3                           |      1  3.0|
      Popliteal, Hyperplasia, Lymphoid     |                                           2                              |      1  2.0|
      Renal, Hyperplasia                   |    3                    4                                                |      2  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  M  M  M  M  M  M  +  M  +  +  M  M  M  M  M  +  +  +  +  M  +|  29        |
      Hyperplasia, Lymphoid                |       2                                                           2      |      4  1.8|
      Hyperplasia                          | 3  2                          1                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  46        |
      Angiectasis                          |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 3| 4| 6| 6| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 8| 0| 3| 3| 3| 4| 2| 9| 3| 7| 7| 3| 3| 3| 9| 2| 2| 3| 3| 0| 1| 3| 3| 3|            |
                                           | 6| 8| 1| 7| 7| 0| 6| 7| 5| 7| 9| 3| 7| 7| 7| 9| 4| 8| 7| 7| 2| 6| 7| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    8 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                |             1              2                       2                     |      4  1.8|
      Hyperplasia                          | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  M  +  +|  45        |
      Hyperplasia, Lymphoid                |       3                    2           2  2           2                  |      6  2.3|
      Hyperplasia                          | 3  4                 2  3     2                                          |      6  2.8|
      Inflammation, Suppurative            |                3                                                         |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          | 2  3                                         2                           |      3  2.3|
      Hyperplasia, Lymphoid                |                            2     3        2                              |      5  2.2|
      Hyperplasia                          | 4  4                                                                     |      2  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     | 4  4  2        3     4  4     3  2           2           3  3            |     17  3.2|
      Hyperplasia, Lymphoid                |    2  2     2              2     2        2        2  2                  |     14  1.9|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  M  +  +  +|  46        |
      Angiectasis                          |                                                          2               |      1  2.0|
      Depletion Lymphoid                   |    2                                                                     |      1  2.0|
      Hyperplasia, Lymphoid                |                            2                                             |      2  2.0|
      Infiltration Cellular, Mixed Cell    |    2                                                                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |          2                 2              2     1  2     1  4  1  2      |     17  2.1|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                             3            |      5  1.6|
      Ulcer                                |                                                             3            |      1  3.0|
      Subcutaneous Tissue, Infiltration    |                                                                          |            |
          Cellular, Mixed Cell             |                               2                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |    2                                                                     |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Suppurative                     |                                                                   3      |      2  3.0|
      Subcutaneous Tissue, Fat, Necrosis   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Distal, Joint, Femur, Arthrosis      |                                                                          |      1  2.0|
      Trabecula, Cranium, Hyperostosis     |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                         +                                                |   2        |
      Hindlimb, Inflammation, Suppurative  |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 3| 4| 6| 6| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 8| 0| 3| 3| 3| 4| 2| 9| 3| 7| 7| 3| 3| 3| 9| 2| 2| 3| 3| 0| 1| 3| 3| 3|            |
                                           | 6| 8| 1| 7| 7| 0| 6| 7| 5| 7| 9| 3| 7| 7| 7| 9| 4| 8| 7| 7| 2| 6| 7| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    8 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                | 1  1        2              2     2  2  2  1        1  2  1     1  1  1  2|     27  1.6|
      Hyperplasia, Macrophage              |       4                                                                  |      2  2.5|
      Infiltration Cellular, Mixed Cell    | 3  3                 2  2     2                                          |      7  2.3|
      Inflammation, Suppurative            |                3                                                         |      2  3.0|
      Fat, Mediastinum, Necrosis           |                                                                          |      1  2.0|
      Mediastinum, Hyperplasia, Lymphoid   |       2                                                                  |      1  2.0|
      Mediastinum, Inflammation,           |                                                                          |            |
          Suppurative                      |    3           4     3        4                                          |      5  3.4|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumen, Exudate                       | 1  2  1  2              2                                   2  3  2     1|     18  1.7|
      Lumen, Foreign Body                  | 1  2  1  2           2  2                 2              1  2  1  2  1  1|     26  1.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                   +              +  +                                    |   6        |
      Acinus, Dilatation                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                         2                                                |      1  2.0|
      Fibrosis                             | 2  2                 2        1                                          |      4  1.8|
      Infiltration Cellular, Mixed Cell    | 2                    2        2                                          |      3  2.0|
      Metaplasia, Osseous                  |                                  2                             2         |      2  2.0|
      Mineralization                       |                                                                          |      2  2.0|
      Nephropathy                          | 2  3  1  2  1        2        1     1     1              1     1  1     1|     21  1.4|
      Renal Tubule, Bacterium              |                      1                                                   |      1  1.0|
      Renal Tubule, Degeneration, Hyaline  |    2                                                                     |      1  2.0|
      Renal Tubule, Dilatation             |                                                                          |      1  2.0|
      Renal Tubule, Pigmentation           |                                                                          |      1  2.0|
      Renal Tubule, Vacuolization          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 3| 4| 6| 6| 7| 4| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 8| 0| 3| 3| 3| 4| 2| 9| 3| 7| 7| 3| 3| 3| 9| 2| 2| 3| 3| 0| 1| 3| 3| 3|            |
                                           | 6| 8| 1| 7| 7| 0| 6| 7| 5| 7| 9| 3| 7| 7| 7| 9| 4| 8| 7| 7| 2| 6| 7| 7| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    8 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
          Cytoplasmic                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |    1        2                       1     2              1               |      6  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 2| 3| 3| 3| 9| 2| 2| 3| 3| 5| 7| 1| 2| 3| 9| 0| 3| 3| 3| 9| 3| 3| 3| 3|             
                                           | 2| 3| 6| 6| 6| 9| 3| 6| 6| 6| 0| 6| 5| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Cyst                         |                2                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                                                          3               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Depletion Glycogen                   |                3                                                         |             
      Eosinophilic Focus                   |                                                                          |             
      Fibrosis, Focal                      |    1                 3                       2                           |             
      Hematopoietic Cell Proliferation     |                                        2                                 |             
      Hyperplasia, Lymphoid                |    1  1  1        1  1  1  1        1  2  1              1  1        1   |             
      Hyperplasia, Multifocal              |                                                                          |             
      Infarct                              |                      2                                                   |             
      Infiltration Cellular, Mixed Cell    |                                                             1            |             
      Inflammation, Multifocal             |    1     1  1     1  1  1                       1  1     1        1      |             
      Necrosis, Multifocal                 |                                                                          |             
      Vacuolization Cytoplasmic            |                2                             2                 1         |             
      Centrilobular, Necrosis              |                               3                                          |             
      Hepatocyte, Cytomegaly               |    1  1                          2     2  1  1  1                        |             
      Hepatocyte, Mitotic Alteration       |                                        2                                 |             
      Hepatocyte, Necrosis                 |    1                                               1                     |             
      Kupffer Cell, Pigmentation           |    1                 2                                                   |             
      Parenchyma, Atrophy, Focal           |                      3                                                   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +     +                                      +|             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Fat, Necrosis                        |                            3                                            3|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Cellular                   |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Inflammation, Focal                  |    2                 1                 2     2        2                  |             
      Mucosa, Erosion                      |                                        2              2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 2| 3| 3| 3| 9| 2| 2| 3| 3| 5| 7| 1| 2| 3| 9| 0| 3| 3| 3| 9| 3| 3| 3| 3|             
                                           | 2| 3| 6| 6| 6| 9| 3| 6| 6| 6| 0| 6| 5| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Mucosa, Hyperplasia, Papillary       |    2                 1                 2              2                  |             
      Mucosa, Ulcer                        |                                              2                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal                  |             2                                                            |             
      Epithelium, Degeneration, Hyaline    |                                                                          |             
      Mucosa, Cyst                         |                                                                          |             
      Mucosa, Mineralization               |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |    +  +  +  +        +     +  +     +  +  +  +        +  +  +  +  +  +  +|             
      Incisor, Dysplasia                   |    1  2  2  2        2     4  1     1  4  4  3        4  2  1  3  3  3  4|             
      Incisor, Inflammation, Suppurative   |                      3     3                             2               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +                                         +                           |             
      Abdominal, Thrombosis                |    X                                                                     |             
      Thoracic, Artery, Mineralization     |                                              3                           |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Cellular                   |                                                                          |             
      Hyperplasia, Focal                   |                            1                                             |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Subcapsular, Hyperplasia, Focal      |          2  1                             1                              |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                   1      |             
      Pars Distalis, Hyperplasia, Focal    |                                                             2            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |          2        1                             1                        |             
      Follicular Cell, Hyperplasia         |                      1                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                         +|             
      Dilatation                           |                                                                         2|             
                                            __________________________________________________________________________|             
   Ductus Deferens                         |                                                       +                  |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 2| 3| 3| 3| 9| 2| 2| 3| 3| 5| 7| 1| 2| 3| 9| 0| 3| 3| 3| 9| 3| 3| 3| 3|             
                                           | 2| 3| 6| 6| 6| 9| 3| 6| 6| 6| 0| 6| 5| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |    2                                                                     |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                   +  +                    +           +                  |             
      Degeneration, Cystic                 |                                                                          |             
      Inflammation, Suppurative            |                   4  3                    4                              |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Dilatation                           |                                                                          |             
      Granuloma                            |                                                                          |             
      Inflammation, Chronic                |                                              1  4                        |             
      Artery, Media, Hyperplasia           |                                           1                              |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                        4                                2|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |          3                                                               |             
      Mineralization                       |                                                                          |             
      Germinal Epithelium, Degeneration    |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Hyperplasia                   |                                                 3                        |             
      Inguinal, Angiectasis                |                         1        2                                       |             
      Inguinal, Congestion                 |                                                                          |             
      Inguinal, Hyperplasia                |                                                 4           2            |             
      Pancreatic, Inflammation, Chronic,   |                                                                          |             
           Focal                           |    2                                                                     |             
      Renal, Hyperplasia                   |                                                 4                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  M  M  M  M  M  M  M  +  M  +  +  +  M  +  M  +  M  M  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +|             
      Hyperplasia, Lymphoid                | 3                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2  2  2  1        2  2              2  2     3  2        1     1  3   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Cellular                   |                                              2                           |             
      Hematopoietic Cell Proliferation     |    2              3  3                                      3            |             
      Hyperplasia, Lymphoid                |       3                                2                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  M  +  +|             
      Cyst                                 |                                                                          |             
      Depletion Lymphoid                   | 2                                            2                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 2| 3| 3| 3| 9| 2| 2| 3| 3| 5| 7| 1| 2| 3| 9| 0| 3| 3| 3| 9| 3| 3| 3| 3|             
                                           | 2| 3| 6| 6| 6| 9| 3| 6| 6| 6| 0| 6| 5| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                   1                                                      |             
      Exudate                              |                                     2                                    |             
      Inflammation, Chronic                |                2  2                 2        2                           |             
      Ulcer                                |                                                                          |             
      Prepuce, Inflammation, Chronic       |                         3                                                |             
      Prepuce, Ulcer                       |                         2                                                |             
      Subcutaneous Tissue, Edema           |                                  3                                       |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Suppurative                     |                                                                          |             
      Subcutaneous Tissue, Thrombosis      |                                  X                                       |             
      Subcutaneous Tissue, Fat, Necrosis   |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Hyperostosis                |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                | 3     1  1  1  1                    2  1  2              2     1  1      |             
      Hyperplasia, Macrophage              | 3           1                       2     2  1  1     2        1     2  3|             
      Inflammation, Suppurative            | 3                                                                        |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Bronchus, Epithelium, Hyperplasia,   |                                                                          |             
           Papillary                       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Exudate                       | 2                 2        2                                2            |             
      Lumen, Foreign Body                  |       2           3                       2                 2            |             
      Lumen, Hemorrhage                    |                   2        2                                             |             
      Lumen, Inflammation, Suppurative     |                            2              2                              |             
      Mucosa, Inflammation, Suppurative    |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                     1                                    |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 2| 3| 3| 3| 9| 2| 2| 3| 3| 5| 7| 1| 2| 3| 9| 0| 3| 3| 3| 9| 3| 3| 3| 3|             
                                           | 2| 3| 6| 6| 6| 9| 3| 6| 6| 6| 0| 6| 5| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Fibrosis                             |    2                                            2                        |             
      Hydronephrosis                       |    3                                                                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Metaplasia, Osseous                  |                                                                         1|             
      Mineralization                       | 1     1  1  1           1  1  1  1  1  1  1  2     1     1     1  1  1  1|             
      Nephropathy                          | 1  3  1  1  1     1  1  1  1           1  1     2  1     1     2  3  2  1|             
      Papilla, Necrosis                    |                                                                          |             
      Pelvis, Dilatation                   |                                                 2                        |             
      Renal Tubule, Cyst                   |                                                                2        2|             
      Renal Tubule, Dilatation             |    3                                         2                           |             
      Renal Tubule, Necrosis               |                                                 2                        |             
      Renal Tubule, Pigmentation           |                                                                          |             
      Renal Tubule, Vacuolization          |                                                                          |             
          Cytoplasmic                      | 2              2              2        1                                 |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 6| 3| 3| 3|            |
                                           | 3| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 4| 0| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mucosa, Cyst                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lymphoid Tissue, Hyperplasia,        |                                                                          |            |
          Lymphoid                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |          1                                                               |      1  1.0|
      Depletion Glycogen                   |                3                                                         |      2  3.0|
      Eosinophilic Focus                   |                               2                                          |      1  2.0|
      Fibrosis, Focal                      |                                                                          |      3  2.0|
      Hematopoietic Cell Proliferation     |                            1                 1                       1   |      4  1.3|
      Hyperplasia, Lymphoid                |    1     1  1        1  1  1     1  1  1  2        1     1              1|     26  1.1|
      Hyperplasia, Multifocal              |                                                             1            |      1  1.0|
      Infarct                              |                                                                          |      1  2.0|
      Infiltration Cellular, Mixed Cell    |                                                                1         |      2  1.0|
      Inflammation, Multifocal             |             1        1     1  1  1  1              1                     |     17  1.0|
      Necrosis, Multifocal                 |                                                                3         |      1  3.0|
      Vacuolization Cytoplasmic            |          1                          1  1  1              2               |      8  1.4|
      Centrilobular, Necrosis              |                                                                          |      1  3.0|
      Hepatocyte, Cytomegaly               |                                                             1            |      8  1.3|
      Hepatocyte, Mitotic Alteration       |                                                                          |      1  2.0|
      Hepatocyte, Necrosis                 |                                                                          |      2  1.0|
      Kupffer Cell, Pigmentation           |                                                                          |      2  1.5|
      Parenchyma, Atrophy, Focal           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                           +                    +     +   |   6        |
      Fibrosis                             |                                                                2         |      1  2.0|
      Inflammation, Chronic                |                                           3                              |      1  3.0|
      Fat, Necrosis                        |                                                                      2   |      3  2.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Depletion Cellular                   |                                                                3         |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 6| 3| 3| 3|            |
                                           | 3| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 4| 0| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
      Cyst Epithelial Inclusion            |                                        1                                 |      1  1.0|
      Inflammation, Focal                  | 1              3     2                                      2            |      9  1.9|
      Mucosa, Erosion                      |                                                                          |      2  2.0|
      Mucosa, Hyperplasia, Papillary       | 1                    2                                      2            |      7  1.7|
      Mucosa, Ulcer                        |                3                                            2            |      3  2.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  49        |
      Inflammation, Focal                  |                                                                          |      1  2.0|
      Epithelium, Degeneration, Hyaline    |       1                                                                  |      1  1.0|
      Mucosa, Cyst                         |          1                                                               |      1  1.0|
      Mucosa, Mineralization               | 1                                                                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
      Incisor, Dysplasia                   | 1  4  3  3  2  1  1  2  3  3  2  2  2  2  2  1  3  2  2  1  1  1  1  2  4|     43  2.3|
      Incisor, Inflammation, Suppurative   |       3                                                                  |      4  2.8|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   2        |
      Abdominal, Thrombosis                |                                                                          |      1     |
      Thoracic, Artery, Mineralization     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Depletion Cellular                   |                3                                                         |      1  3.0|
      Hyperplasia, Focal                   |                                                       1                  |      2  1.0|
      Vacuolization Cytoplasmic, Focal     |                                                          3               |      1  3.0|
      Subcapsular, Hyperplasia, Focal      |                      2        2        1     2                           |      7  1.6|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                          2        1      |      2  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Cyst                  | 2           2                    1  2  2                                 |      6  1.7|
      Pars Distalis, Hyperplasia, Focal    |                                                       1                  |      2  1.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                2           1                    2                        |      6  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 6| 3| 3| 3|            |
                                           | 3| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 4| 0| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Follicular Cell, Hyperplasia         | 1     2                                   1                              |      4  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
      Dilatation                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ductus Deferens                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |                               1                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                            +                                +            |   6        |
      Degeneration, Cystic                 |                            2                                             |      1  2.0|
      Inflammation, Suppurative            |                            4                                3            |      5  3.6|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Degeneration, Cystic                 |                                                                   2      |      1  2.0|
      Dilatation                           | 2                                                                        |      1  2.0|
      Granuloma                            |                                              2                           |      1  2.0|
      Inflammation, Chronic                |                                                                          |      2  2.5|
      Artery, Media, Hyperplasia           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                                                                          |      2  3.0|
      Inflammation, Chronic                |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma Sperm                      |                                                                          |      1  3.0|
      Mineralization                       |                            2                                             |      1  2.0|
      Germinal Epithelium, Degeneration    |                            2                                      3      |      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Iliac, Hyperplasia                   |                                                                          |      1  3.0|
      Inguinal, Angiectasis                |                                                                          |      2  1.5|
      Inguinal, Congestion                 |                                                                2         |      1  2.0|
      Inguinal, Hyperplasia                |                                              3                       1   |      4  2.5|
      Pancreatic, Inflammation, Chronic,   |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Renal, Hyperplasia                   |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  M  +  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|  14        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 6| 3| 3| 3|            |
                                           | 3| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 4| 0| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                3                                                  2      |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  M  M  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  M  M  M|  38        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |             2           2  2  1     1        2                    1     2|     21  1.8|
      Hematopoietic Cell Proliferation     |                                                                4         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Depletion Cellular                   |                2                                                         |      2  2.0|
      Hematopoietic Cell Proliferation     |                                                 3                        |      5  2.8|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  M  M  +  +  +  +  M  +|  42        |
      Cyst                                 |                   1                                                      |      1  1.0|
      Depletion Lymphoid                   |                3                                                         |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                          |      1  1.0|
      Exudate                              |                                                                          |      1  2.0|
      Inflammation, Chronic                |                3     3  2  2                       2                    2|     11  2.2|
      Ulcer                                |                4        1  1                       2                     |      4  2.0|
      Prepuce, Inflammation, Chronic       |                                                                          |      1  3.0|
      Prepuce, Ulcer                       |                                                                          |      1  2.0|
      Subcutaneous Tissue, Edema           |                                                                          |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Suppurative                     |                                              3                           |      1  3.0|
      Subcutaneous Tissue, Thrombosis      |                                                                          |      1     |
      Subcutaneous Tissue, Fat, Necrosis   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cranium, Hyperostosis                |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                              +                           |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 6| 3| 3| 3|            |
                                           | 3| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 4| 0| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |       2                                                                  |      1  2.0|
      Hyperplasia, Lymphoid                |    1  2  1                 2  1  1  1              2  1  1  1           1|     23  1.3|
      Hyperplasia, Macrophage              |    1                       1                       1        1     1      |     15  1.5|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                           3                    2         |      2  2.5|
      Bronchus, Epithelium, Hyperplasia,   |                                                                          |            |
           Papillary                       |                                     1                                    |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumen, Exudate                       | 3  1     1  2           1  2  2     1           1  1                 1  2|     16  1.6|
      Lumen, Foreign Body                  | 3  1     1  2           1     2     1        2  1  1                 1  1|     16  1.6|
      Lumen, Hemorrhage                    |                                                                          |      2  2.0|
      Lumen, Inflammation, Suppurative     |                                                                          |      2  2.0|
      Mucosa, Inflammation, Suppurative    |                            1                                             |      1  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                              +                    +      |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis, Focal                      |                                              2                           |      1  2.0|
      Fibrosis                             |                                                                          |      2  2.0|
      Hydronephrosis                       |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                3         |      1  3.0|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Mineralization                       |    1        1  1  1  1  1  1  1     1  1  1     1  1     1     1  1  1  1|     36  1.0|
      Nephropathy                          | 3  2  1  1  1     1  1     1  2  1  1  1  1  1  2  1  1  1  3  3  1  1  2|     41  1.4|
      Papilla, Necrosis                    |                                                 3                        |      1  3.0|
      Pelvis, Dilatation                   |                                                                          |      1  2.0|
      Renal Tubule, Cyst                   | 2                                                                        |      3  2.0|
      Renal Tubule, Dilatation             |                2                                                         |      3  2.3|
      Renal Tubule, Necrosis               |                                                                          |      1  2.0|
      Renal Tubule, Pigmentation           |                                                                3         |      1  3.0|
      Renal Tubule, Vacuolization          |                                                                          |            |
          Cytoplasmic                      |                2                                               3         |      6  2.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                +         |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| 6| 3| 3| 3|            |
                                           | 3| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 4| 0| 8| 8| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                              2                           |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 5| 2| 3| 3| 4| 1| 3| 3| 3| 2| 3| 3| 3| 3| 4| 4| 9| 3| 3| 8| 1| 2| 2| 3|             
                                           | 3| 6| 2| 1| 6| 2| 6| 3| 6| 6| 6| 6| 6| 6| 6| 1| 9| 1| 6| 6| 9| 8| 4| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    15 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Epithelium, Metaplasia,      |                                                                          |             
          Squamous                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                3                                                         |             
      Mucosa, Ulcer                        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                      3                                                   |             
      Mucosa, Hyperplasia, Papillary       |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       3                       3                                         2|             
      Basophilic Focus, Multiple, Two      |                                                                         2|             
      Clear Cell Focus                     |                                                                          |             
      Clear Cell Focus, Multiple, Three    |                                                                          |             
      Cyst                                 |                            3                                             |             
      Cytoplasmic Alteration, Focal        |                                  2                                       |             
      Eosinophilic Focus                   |                                                                          |             
      Hematopoietic Cell Proliferation     |       2                                                                  |             
      Hemorrhage                           |                                                 4                        |             
      Hyperplasia, Lymphoid                |          1  2     1  1  2     1  1     1  1  1        2  1               |             
      Hyperplasia, Multifocal              | 2  2  4  3  2  3  3  3  3  2  3  2  2  3  3  2  3  3  2  3  3  3  3  3  3|             
      Infarct                              | 2     4  4                                      3                        |             
      Infarct, Multiple, Two               |                                              4                           |             
      Infiltration Cellular, Mixed Cell    | 2  2  3  1        1  1  2     1  2     1     1  1  1     1  1  1  2     1|             
      Inflammation, Multifocal             | 2                                                                        |             
      Mineralization                       |                                                                          |             
      Mixed Cell Focus                     |                                                                      2   |             
      Necrosis, Multifocal                 |       2                                                                  |             
      Thrombosis                           |                                                                          |             
      Vacuolization Cytoplasmic            |          2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  1  2   |             
      Artery, Inflammation, Chronic        |                                                                          |             
      Bile Duct, Dilatation                |          3                                   2                    3      |             
      Biliary Tract, Fibrosis              | 2  3  3  3  3  4  3  3  3  2  3  2  2  3  2  2  2  3  2  3  3  3  3  2  3|             
      Biliary Tract, Hyperplasia           | 2  2  3  3  3  4  3  3  3  3  3  2  2  2  2  2  1  3  2  3  3  3  3  2  3|             
      Biliary Tract, Inflammation, Chronic | 2  2  3  2  2  3  2  2  3  2  2  2  2  2  2  2  2  3  2  2  3  2  3  2  3|             
      Centrilobular, Necrosis              |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 5| 2| 3| 3| 4| 1| 3| 3| 3| 2| 3| 3| 3| 3| 4| 4| 9| 3| 3| 8| 1| 2| 2| 3|             
                                           | 3| 6| 2| 1| 6| 2| 6| 3| 6| 6| 6| 6| 6| 6| 6| 1| 9| 1| 6| 6| 9| 8| 4| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    15 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Hepatocyte, Cytomegaly               | 2  2  3  3  2  3  3  2  3  2  2  2  2  3  2  3  3  3  2  3  3  3  2  3  3|             
      Hepatocyte, Degeneration             | 2  2  3        2  2  2  2  2  2     1  2  1  2  1  2  1  2  2  2  2  2  2|             
      Hepatocyte, Necrosis                 | 2  2  2  1  1  2  1  1  2  2  2  2  1  1  1  1  1  1  1  1  2  1  2  1  2|             
      Hepatocyte, Pigmentation             |                         2                                                |             
      Kupffer Cell, Pigmentation           | 2  1  3  2  2  3  2  2  2  2  3  2  2  2  1  2  2  3  1  2  2  2  2  1  2|             
      Parenchyma, Atrophy, Multifocal      | 3  3  3  3  3  4  3  3  3  4  3  2  2  3  3  2  3  3  2  2  4  2  3  3  3|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atypia Cellular, Focal               |                                                       1                  |             
      Duct, Dilatation                     |          3                                                               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                              1                           |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal                  |          2           2  2           2  2  2        1     2     2     3  2|             
      Mucosa, Erosion                      |                                        1  2                             2|             
      Mucosa, Hyperplasia, Papillary       |          2           3  2  2        2  2  2        2  2        3     3  2|             
      Mucosa, Inflammation, Focal          |                                                                          |             
      Mucosa, Mineralization               |                                                          2               |             
      Mucosa, Ulcer                        |                                                                      3   |             
      Mucosa, Ulcer, Multiple, Two         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal                  |             1        1                                   2               |             
      Mucosa, Cyst                         |                                                                          |             
      Mucosa, Dysplasia                    |                                                                          |             
      Mucosa, Erosion                      |                                                                          |             
      Mucosa, Hyperplasia, Papillary       |                                                                          |             
      Mucosa, Mineralization               |                                                          2               |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |    +  +  +  +  +     +        +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Incisor, Dysplasia                   |    2  2  3  1  3     4        1  1  2  2  1  1  1        2  3  1  2  1  3|             
      Incisor, Inflammation, Suppurative   |                2                                         3              3|             
      Molar, Inflammation, Suppurative     |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                   +                                                      |             
      Abdominal, Inflammation, Chronic     |                   2                                                      |             
      Abdominal, Adventitia, Thrombosis    |                   4                                                      |             
      Aorta, Media, Mineralization         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 5| 2| 3| 3| 4| 1| 3| 3| 3| 2| 3| 3| 3| 3| 4| 4| 9| 3| 3| 8| 1| 2| 2| 3|             
                                           | 3| 6| 2| 1| 6| 2| 6| 3| 6| 6| 6| 6| 6| 6| 6| 1| 9| 1| 6| 6| 9| 8| 4| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    15 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Mesenteric Artery, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
      Mesenteric Artery, Media,            |                                                                          |             
          Mineralization                   |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                1         |             
      Coronary Artery, Mineralization      |                                                                          |             
      Myocardium, Mineralization           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                        1                                 |             
      Subcapsular, Hyperplasia, Focal      |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |             1                 2                                   3      |             
      Hyperplasia                          |          2                                   2     3                     |             
      Extra Adrenal Tissue, Ectopic Tissue |                   2                                                      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Focal Cellular Change |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                       2                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                            2        2                                    |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                1                                   2     1               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                   2                                            2         |             
      Inflammation, Chronic                |                                                                2         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +                       +              +                             +   |             
      Degeneration, Cystic                 | 3                       3              3                             3   |             
      Inflammation, Suppurative            |                         2                                            3   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                      3                                                   |             
      Edema                                |                                                             2            |             
      Hyperplasia, Lymphoid                |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 5| 2| 3| 3| 4| 1| 3| 3| 3| 2| 3| 3| 3| 3| 4| 4| 9| 3| 3| 8| 1| 2| 2| 3|             
                                           | 3| 6| 2| 1| 6| 2| 6| 3| 6| 6| 6| 6| 6| 6| 6| 1| 9| 1| 6| 6| 9| 8| 4| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    15 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                    1                     |             
      Germinal Epithelium, Degeneration    |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Focal, Osseous           |                                                       3                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Angiectasis                |       3                                                                  |             
      Inguinal, Hyperplasia                |       2                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  M  M  +  M  +  +  M  +  +  +  +  +  M  +  M  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  M  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Hyperplasia                          |       2  2                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                             4  3         |             
      Hyperplasia, Lymphoid                |                                                                      3   |             
      Hyperplasia                          |                                                                3         |             
      Inflammation, Suppurative            |       2                                                                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    4  3  2           2                 2           2     2  2            |             
      Artery, Degeneration, Hyaline        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +|             
      Depletion Lymphoid                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                                           1                              |             
      Inflammation, Chronic                |       4                                1  2              2               |             
      Ulcer                                |       4                                1                 2               |             
      Hair Follicle, Atrophy               |                                                             3            |             
      Prepuce, Fibrosis                    |                                     2                                    |             
      Prepuce, Inflammation, Chronic       |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 5| 2| 3| 3| 4| 1| 3| 3| 3| 2| 3| 3| 3| 3| 4| 4| 9| 3| 3| 8| 1| 2| 2| 3|             
                                           | 3| 6| 2| 1| 6| 2| 6| 3| 6| 6| 6| 6| 6| 6| 6| 1| 9| 1| 6| 6| 9| 8| 4| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    15 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                        2                    3            |             
      Granuloma                            |          2                                      1                        |             
      Hyperplasia, Lymphoid                |    1     1  1        1  1  2     1     1  1        1  1  2           1  1|             
      Hyperplasia, Macrophage              | 1        2           2                 1  1        1        1  1  1  1  2|             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             
      Inflammation, Chronic, Focal         |                         1                                                |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Inflammation, Focal                  |                                                                          |             
      Pigmentation                         |                                           1                              |             
      Alveolar Epithelium, Hyperplasia     |             1        1                                                   |             
      Bronchiole, Hyperplasia              |                                  2                                       |             
      Mediastinum, Hemorrhage              |                                                             3            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Exudate                       |                                                                      2   |             
      Lumen, Foreign Body                  |                                                                2     2   |             
      Lumen, Inflammation, Suppurative     |                                        2                       2         |             
      Mucosa, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                    3                     |             
      Congestion                           |                                                             3            |             
      Fibrosis                             |                                                    3                     |             
      Hydronephrosis                       |                   3                                3                     |             
      Mineralization                       | 1  1  1  1  1  1     1     1  1  1  1     1  2  1     1  1  1     1  1  1|             
      Nephropathy                          | 1        3  1  4  4  2  2  2  1  2     2           3  1  3  3  3  2  2  2|             
      Capsule, Fibrosis                    |       2                                                                  |             
                                            __________________________________________________________________________|             
   Ureter                                  |                               +                 +                        |             
      Serosa, Hyperplasia, Lymphoid        |                               3                 2                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                    2     1               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 5| 6| 5| 7| 7| 6| 7| 7| 7| 7| 4| 5| 6| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 1| 1| 1| 3| 3| 5| 1| 7| 2| 3| 2| 1| 2| 3| 3| 9| 9| 6| 3| 3| 2| 6| 2| 2| 3|            |
                                           | 0| 8| 8| 6| 6| 6| 2| 7| 5| 6| 1| 8| 4| 6| 6| 8| 5| 3| 6| 6| 1| 8| 3| 5| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    15 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mucosa, Epithelium, Metaplasia,      |                                                                          |            |
          Squamous                         |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  48        |
      Inflammation, Chronic                |                                                             3            |      2  3.0|
      Mucosa, Ulcer                        |                                                             4            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  48        |
      Lymphoid Tissue, Hyperplasia,        |                                                                          |            |
          Lymphoid                         |                                                                          |      1  3.0|
      Mucosa, Hyperplasia, Papillary       |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      3  2.7|
      Basophilic Focus, Multiple, Two      |                                                                          |      1  2.0|
      Clear Cell Focus                     |                                           2                              |      1  2.0|
      Clear Cell Focus, Multiple, Three    |                                                                      2   |      1  2.0|
      Cyst                                 |                                                                          |      1  3.0|
      Cytoplasmic Alteration, Focal        |                                                                          |      1  2.0|
      Eosinophilic Focus                   |                                           2                              |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                    2                     |      2  2.0|
      Hemorrhage                           | 4                                                                        |      2  4.0|
      Hyperplasia, Lymphoid                |    2  1  1  1              1     1  2                    2        1  2   |     22  1.3|
      Hyperplasia, Multifocal              | 3  3  3  3  2  2     3  2  2  3  3  3  2  3  2  2  3  2  3  3  3  3  3  3|     49  2.7|
      Infarct                              | 4     2        4  4                          2     4                 4   |     11  3.4|
      Infarct, Multiple, Two               |                                                                          |      1  4.0|
      Infiltration Cellular, Mixed Cell    |    1  1                 1     1     1     1  2  1  1     1        1      |     29  1.3|
      Inflammation, Multifocal             |             2                                                            |      2  2.0|
      Mineralization                       |       3           3                 3                                    |      3  3.0|
      Mixed Cell Focus                     |                                                                          |      1  2.0|
      Necrosis, Multifocal                 | 3                 3                                                      |      3  2.7|
      Thrombosis                           |       3                                                                  |      1  3.0|
      Vacuolization Cytoplasmic            |    1     1  2     2     3        2  2     2        2  1  2     2  2  2  2|     36  1.9|
      Artery, Inflammation, Chronic        |                                                             3            |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 5| 6| 5| 7| 7| 6| 7| 7| 7| 7| 4| 5| 6| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 1| 1| 1| 3| 3| 5| 1| 7| 2| 3| 2| 1| 2| 3| 3| 9| 9| 6| 3| 3| 2| 6| 2| 2| 3|            |
                                           | 0| 8| 8| 6| 6| 6| 2| 7| 5| 6| 1| 8| 4| 6| 6| 8| 5| 3| 6| 6| 1| 8| 3| 5| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    15 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Bile Duct, Dilatation                |       3                                2  3                              |      6  2.7|
      Biliary Tract, Fibrosis              | 2  3  3  2  2  2     2  2  2  3  3  3  2  2  2  2  3  2  3  3  3  3  3  3|     49  2.6|
      Biliary Tract, Hyperplasia           | 2  3  3  3  2  2     2  2  2  3  3  3  2  2  2  2  3  2  3  3  3  3  3  3|     49  2.6|
      Biliary Tract, Inflammation, Chronic | 2  2  2  2  2  2     2  2  1  3  3  2  2  2  1  2  2  2  2  2  2  2  2  2|     49  2.1|
      Centrilobular, Necrosis              |                                                                          |      1  2.0|
      Hepatocyte, Cytomegaly               | 2  3  3  3  2  2  2  2  2  2  3  2  2  2  3  2  2  2  2  2  2  3  3  2  2|     50  2.4|
      Hepatocyte, Degeneration             | 2  2  2  2  1  1     2        2  2  2     2  2  2  2  2  2  2  2  2  2  2|     43  1.9|
      Hepatocyte, Necrosis                 |    1     1     1     2           1  1     1  2  1     1  1  1  1  1  1  1|     41  1.3|
      Hepatocyte, Pigmentation             |                                                                          |      1  2.0|
      Kupffer Cell, Pigmentation           | 2  2  2  2  1  2  2  2  2  1  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2|     50  1.9|
      Parenchyma, Atrophy, Multifocal      | 2  4  3  2  3  3  2  3  3  2  3  3  3  3  3  2  2  3  3  3  3  3  3  3  3|     50  2.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                    +        +  +         |   3        |
      Fibrosis                             |                                                                4         |      1  4.0|
      Inflammation, Chronic                |                                                             3            |      1  3.0|
      Mineralization                       |                                                                4         |      1  4.0|
      Necrosis                             |                                                                4         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atypia Cellular, Focal               |                                                                          |      1  1.0|
      Duct, Dilatation                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  48        |
      Hyperplasia, Lymphoid                |             1              1           1                                 |      4  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Focal                  |    2                    2     2  1        2  2  2        1  2        1   |     21  1.9|
      Mucosa, Erosion                      |                         1     2              2                           |      6  1.7|
      Mucosa, Hyperplasia, Papillary       |    1                    2     2  1        2  2  2        1  2  2     2   |     23  2.0|
      Mucosa, Inflammation, Focal          |                                                                2         |      1  2.0|
      Mucosa, Mineralization               |                      2                                                   |      2  2.0|
      Mucosa, Ulcer                        |    2                                            2                        |      3  2.3|
      Mucosa, Ulcer, Multiple, Two         |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Focal                  |    1                                                                     |      4  1.3|
      Mucosa, Cyst                         |                                              2                           |      1  2.0|
      Mucosa, Dysplasia                    |                                                          1               |      1  1.0|
      Mucosa, Erosion                      |    1                                                                     |      1  1.0|
      Mucosa, Hyperplasia, Papillary       |    2                                                                     |      1  2.0|
      Mucosa, Mineralization               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                +         |   1        |
      Hemorrhage                           |                                                                2         |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 5| 6| 5| 7| 7| 6| 7| 7| 7| 7| 4| 5| 6| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 1| 1| 1| 3| 3| 5| 1| 7| 2| 3| 2| 1| 2| 3| 3| 9| 9| 6| 3| 3| 2| 6| 2| 2| 3|            |
                                           | 0| 8| 8| 6| 6| 6| 2| 7| 5| 6| 1| 8| 4| 6| 6| 8| 5| 3| 6| 6| 1| 8| 3| 5| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    15 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tooth                                   |          +  +  +     +     +  +     +  +        +        +  +  +        +|  32        |
      Incisor, Dysplasia                   |          4  2  1     1     1  1     1  2        1        1  1  2        1|     32  1.7|
      Incisor, Inflammation, Suppurative   |             2                                               1            |      5  2.2|
      Molar, Inflammation, Suppurative     |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                               +                             +  +         |   4        |
      Abdominal, Inflammation, Chronic     |                                                                          |      1  2.0|
      Abdominal, Adventitia, Thrombosis    |                                                                          |      1  4.0|
      Aorta, Media, Mineralization         |                               4                             2            |      2  3.0|
      Mesenteric Artery, Inflammation,     |                                                                          |            |
           Chronic                         |                                                             3  2         |      2  2.5|
      Mesenteric Artery, Media,            |                                                                          |            |
          Mineralization                   |                               4                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Coronary Artery, Mineralization      |                                                             3            |      1  3.0|
      Myocardium, Mineralization           |                                                             2            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                      3                                                   |      2  2.0|
      Subcapsular, Hyperplasia, Focal      |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |    1                    1     2  2        1                 2            |      9  1.7|
      Hyperplasia                          |                                                                          |      3  2.3|
      Extra Adrenal Tissue, Ectopic Tissue |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  48        |
      Cyst                                 |                            2                                             |      1  2.0|
      Pars Distalis, Cyst                  |             1                 2                                      2   |      3  1.7|
      Pars Distalis, Focal Cellular Change |                                                    1                     |      1  1.0|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                                                             1     1      |      4  1.5|
      Follicle, Cyst                       |                               2                                          |      1  2.0|
      Follicular Cell, Hyperplasia         |                                                                          |      3  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 5| 6| 5| 7| 7| 6| 7| 7| 7| 7| 4| 5| 6| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 1| 1| 1| 3| 3| 5| 1| 7| 2| 3| 2| 1| 2| 3| 3| 9| 9| 6| 3| 3| 2| 6| 2| 2| 3|            |
                                           | 0| 8| 8| 6| 6| 6| 2| 7| 5| 6| 1| 8| 4| 6| 6| 8| 5| 3| 6| 6| 1| 8| 3| 5| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    15 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                         +|   5        |
      Degeneration, Cystic                 |                                                                          |      4  3.0|
      Inflammation, Suppurative            |                                                                         4|      3  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dilatation                           |                                                                      2   |      2  2.5|
      Edema                                |    2                                                                     |      2  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                          |      1  1.0|
      Germinal Epithelium, Degeneration    |                                                                2         |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Metaplasia, Focal, Osseous           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inguinal, Angiectasis                |                                                                          |      1  3.0|
      Inguinal, Hyperplasia                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  M  +  M  M  M  M  +  M  M  +  M  M  +  M  M  +  +  M  +  M  M  +  M|  26        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | A  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  41        |
      Depletion Lymphoid                   |                                                                2         |      1  2.0|
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | A  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |             2        2                          3           4            |      6  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |    3  2                                2     3     3     2        3      |     15  2.5|
      Artery, Degeneration, Hyaline        |                                                                3         |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 5| 6| 5| 7| 7| 6| 7| 7| 7| 7| 4| 5| 6| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 1| 1| 1| 3| 3| 5| 1| 7| 2| 3| 2| 1| 2| 3| 3| 9| 9| 6| 3| 3| 2| 6| 2| 2| 3|            |
                                           | 0| 8| 8| 6| 6| 6| 2| 7| 5| 6| 1| 8| 4| 6| 6| 8| 5| 3| 6| 6| 1| 8| 3| 5| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    15 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  | A  +  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  M  +  +  +  +|  42        |
      Depletion Lymphoid                   |                                              2                           |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Exudate                              |                                                                          |      1  1.0|
      Inflammation, Chronic                |                         2                 2                          2   |      7  2.1|
      Ulcer                                |                                           1                              |      4  2.0|
      Hair Follicle, Atrophy               |                                                                          |      1  3.0|
      Prepuce, Fibrosis                    |                                                                          |      1  2.0|
      Prepuce, Inflammation, Chronic       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                 2                       3|      4  2.5|
      Granuloma                            |                                                                          |      2  1.5|
      Hyperplasia, Lymphoid                |    2  1     1           1  2           1  2           2        1         |     23  1.3|
      Hyperplasia, Macrophage              |    2                 2                 1  3                 2     1      |     17  1.5|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                2                                                         |      1  2.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  1.0|
      Inflammation, Focal, Granulomatous   |                         1                                                |      1  1.0|
      Inflammation, Focal                  |                                                                   1      |      1  1.0|
      Pigmentation                         |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  1.0|
      Bronchiole, Hyperplasia              |                                                                          |      1  2.0|
      Mediastinum, Hemorrhage              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumen, Exudate                       |                                                                          |      1  2.0|
      Lumen, Foreign Body                  |    2     1  3                                      1                     |      6  1.8|
      Lumen, Inflammation, Suppurative     |             3                                                            |      3  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 5| 6| 5| 7| 7| 6| 7| 7| 7| 7| 4| 5| 6| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 1| 1| 1| 3| 3| 5| 1| 7| 2| 3| 2| 1| 2| 3| 3| 9| 9| 6| 3| 3| 2| 6| 2| 2| 3|            |
                                           | 0| 8| 8| 6| 6| 6| 2| 7| 5| 6| 1| 8| 4| 6| 6| 8| 5| 3| 6| 6| 1| 8| 3| 5| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    15 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Mucosa, Inflammation, Suppurative    |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                  +                                       |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Congestion                           |                                                                          |      1  3.0|
      Fibrosis                             |                                                                          |      1  3.0|
      Hydronephrosis                       |                                              3                 3         |      4  3.0|
      Mineralization                       | 1     1  1  1  1  1  1  1  1  2  1  1  1  2     1     1  1  1     2  1  1|     41  1.1|
      Nephropathy                          |    3  1  1  2     1  1  1  1  2     1  1  1  4        1  2  4  4  3  1   |     38  2.1|
      Capsule, Fibrosis                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   2        |
      Serosa, Hyperplasia, Lymphoid        |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           | 3                                                                        |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 1| 1| 3| 3| 2| 3| 3| 3| 3| 5| 4| 9| 1| 3| 0| 3| 3| 3| 3| 8| 0| 3| 3| 3|             
                                           | 1| 9| 9| 6| 6| 5| 1| 3| 6| 6| 7| 2| 7| 9| 6| 4| 3| 3| 6| 6| 4| 0| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    8 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Perforation                          |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Mucosa, Hyperplasia, Papillary       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |             2                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                2                                                         |             
      Basophilic Focus                     |                2                                                         |             
      Clear Cell Focus                     |                                                                      X   |             
      Congestion                           |                                                                          |             
      Cyst                                 |                         3                                                |             
      Cyst, Multiple                       |                3                                                         |             
      Degeneration, Cystic                 |                                                                          |             
      Depletion Glycogen                   |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Hyperplasia, Lymphoid                |       2  1  1  1        1           2     1  2  1     2           1  2  2|             
      Hyperplasia, Multifocal              | 2  2  1  2  1  2  1  2  1  2  2  2  2  2  2  3  2  2  2  2  2     2  3  2|             
      Infarct                              |       3              4        2     4  3  1  3  4  2        4        1   |             
      Infiltration Cellular, Mixed Cell    |       2        2     2  1     2  2  2  1           2        1            |             
      Inflammation, Multifocal             |       1                                   1                          1   |             
      Mixed Cell Focus                     |             2  2                                                         |             
      Necrosis, Multifocal                 |                                                                          |             
      Thrombosis                           |                      3                       3                           |             
      Vacuolization Cytoplasmic            |          2           1  1  2  2     2        3  2  2     2  2     2     2|             
      Biliary Tract, Fibrosis              | 3  2  1  2  1     2  2  2  2  2  1  2  2  2  3  2  2  1  2  3     1  2  2|             
      Biliary Tract, Hyperplasia           | 2  2  1  2  1  1  2  2  1  2  2  2  2  2  2  3  2  2  1  2  3     1  2  2|             
      Biliary Tract, Inflammation, Chronic | 2  1  1  1  1  1  1  1  1  1  2  1  2  1  2  3  1  2  1  2  2        2  1|             
      Centrilobular, Necrosis              |                                                                          |             
      Hepatocyte, Cytomegaly               | 2  2  1  2  1  2  1  3  2  2  2  2  2  2  2  3  2  2  2  2  2     2  3  2|             
      Hepatocyte, Degeneration             | 1  1  1  1  1  2     2  1  1  1  2  3  2  2  3  2  2  2  2  2     2  2  2|             
      Hepatocyte, Mitotic Alteration       |                      2                                                   |             
      Hepatocyte, Necrosis                 | 1  1  1  1     2     3  1     2  1  1  1  1  3  2  1     1  1  1  1  1  1|             
      Kupffer Cell, Pigmentation           | 1  2  2  1  1  1  1     1  2  2     1  1  1  2  1  1  1  1  2  1  1  2  1|             
      Parenchyma, Atrophy, Multifocal      | 3  2     3  1  2  2  1  3  2  2  1  2  2  1  3  2  3  1  2  3     3  2  3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 1| 1| 3| 3| 2| 3| 3| 3| 3| 5| 4| 9| 1| 3| 0| 3| 3| 3| 3| 8| 0| 3| 3| 3|             
                                           | 1| 9| 9| 6| 6| 5| 1| 3| 6| 6| 7| 2| 7| 9| 6| 4| 3| 3| 6| 6| 4| 0| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    8 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Serosa, Fibrosis, Focal              |                                                                          |             
      Serosa, Pigmentation, Focal          |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                          +  +           +     +        +            |             
      Hyperplasia, Lymphoid                |                                              3                           |             
      Infarct                              |                                                    3                     |             
      Mineralization                       |                                                    3                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                        2                                 |             
      Hyperplasia, Lymphoid                |                                           1                              |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                              3           1               |             
      Adventitia, Inflammation, Chronic    |       3                                                                  |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal                  |                   3  1  1        1              2              2  1  1   |             
      Mineralization, Focal                |                                                                          |             
      Mucosa, Edema                        |                                                                          |             
      Mucosa, Erosion                      |                   3                             2              2     1   |             
      Mucosa, Hyperplasia, Papillary       |                   3  1  2        1     2        2              2  2  1   |             
      Mucosa, Ulcer                        |                   3  1           1                                       |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal                  |                            2              2                              |             
      Mineralization                       |                                                                      2  2|             
      Epithelium, Degeneration, Hyaline    |                            2              1                              |             
      Epithelium, Metaplasia, Squamous     |                                                                          |             
      Mucosa, Cyst                         |                                                                          |             
      Mucosa, Cyst, Multiple               |                                                                          |             
      Mucosa, Erosion                      |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                    +                     |             
                                            __________________________________________________________________________|             
   Tooth                                   |    +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +     +|             
      Incisor, Dysplasia                   |    1  1  1  3  2  2  1  1  1  2  1     1  2  1  4  1  2  3     1  1     2|             
      Incisor, Inflammation, Suppurative   |             4                                                            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                    +                     |             
      Aorta, Mineralization                |                                                    3                     |             
      Mesenteric Artery, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
      Renal Artery, Mineralization         |                                                    2                     |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 1| 1| 3| 3| 2| 3| 3| 3| 3| 5| 4| 9| 1| 3| 0| 3| 3| 3| 3| 8| 0| 3| 3| 3|             
                                           | 1| 9| 9| 6| 6| 5| 1| 3| 6| 6| 7| 2| 7| 9| 6| 4| 3| 3| 6| 6| 4| 0| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    8 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Subcapsular, Hyperplasia, Focal      |       1                                               2                  |             
      Subcapsular, Hyperplasia             |          3                                         3                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   | 2           1        3                                                   |             
      Hyperplasia                          |       2                             3                                    |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Multiple                       |                                                       3                  |             
      Hyperplasia                          |                                                       3                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                             2            |             
      Pars Distalis, Cyst                  |                                                                1         |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
      Pars Nervosa, Angiectasis            |                                                             2            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |             1  2                             2  1                        |             
      Degeneration                         |                                                                          |             
      Follicular Cell, Hyperplasia         |    2                 1                    1                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                            +                                             |             
      Dilatation                           |                            4                                             |             
      Hyperplasia, Adenomatous             |                            2                                             |             
                                            __________________________________________________________________________|             
   Ductus Deferens                         |    +                    +                                                |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma                            |                                                                          |             
      Granuloma Sperm                      |                                                 2                        |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +  +                       +                       +           +   |             
      Degeneration, Cystic                 |       3                          3                       1           3   |             
      Fibrosis                             |                                  4                                       |             
      Inflammation, Suppurative            | 3     3  2                                                               |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                 2                        |             
      Dilatation                           |                2                                                         |             
      Edema                                |                2                                   2                     |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 1| 1| 3| 3| 2| 3| 3| 3| 3| 5| 4| 9| 1| 3| 0| 3| 3| 3| 3| 8| 0| 3| 3| 3|             
                                           | 1| 9| 9| 6| 6| 5| 1| 3| 6| 6| 7| 2| 7| 9| 6| 4| 3| 3| 6| 6| 4| 0| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    8 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                                           2                    2  2      |             
      Germinal Epithelium, Degeneration    |                                           2                       2      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pancreatic, Hyperplasia, Lymphoid    |                                              3                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  M  M  +  M  +  +  +  +  +  M  M  M  M  +  +  M  M  +  +  M  M  +  +  +|             
      Hyperplasia, Lymphoid                |                            2                             2               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                2  2                          3                           |             
      Hyperplasia                          |                                                       3                  |             
      Pigmentation                         |                   2                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                2           2                 3           2               |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2           2                    2        2                        |             
      Hyperplasia, Lymphoid                |                            2                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   | 2                                                                        |             
      Hematopoietic Cell Proliferation     |             2  4     2              2        4                 3         |             
      Hyperplasia, Lymphoid                |                            2              2  3                           |             
      Red Pulp, Depletion Cellular         |                                                    2                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Depletion Lymphoid                   |                                     1  2           2                     |             
      Hyperplasia, Lymphoid                |                2                             3                           |             
      Epithelial Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                        2  1                              |             
      Ulcer                                |                                        2                                 |             
      Prepuce, Fibrosis                    |                               3                                          |             
      Subcutaneous Tissue, Congestion      |                                                                          |             
      Subcutaneous Tissue, Edema           |                                              3                           |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |       3                                                                  |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Suppurative                     |                         4                                                |             
      Subcutaneous Tissue, Head,           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 1| 1| 3| 3| 2| 3| 3| 3| 3| 5| 4| 9| 1| 3| 0| 3| 3| 3| 3| 8| 0| 3| 3| 3|             
                                           | 1| 9| 9| 6| 6| 5| 1| 3| 6| 6| 7| 2| 7| 9| 6| 4| 3| 3| 6| 6| 4| 0| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    8 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
          Hyperplasia, Mast Cell           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Distal, Joint, Femur, Arthrosis      |                                  4                       3               |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                               +                             +            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 2                                                           3            |             
      Hyperplasia, Lymphoid                |       2  2     1     1     1           1  1     1        2           1   |             
      Hyperplasia, Macrophage              | 1           1     1        2  1  2  2                                   2|             
      Alveolar Epithelium, Hyperplasia     |             2     2                                2                     |             
      Mediastinum, Foreign Body            |                                                                          |             
      Mediastinum, Inflammation,           |                                                                          |             
          Suppurative                      |                                                                          |             
      Pleura, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Exudate                       |                                           2  2  2              2         |             
      Lumen, Foreign Body                  | 2     1                             2     2  2  2                        |             
      Lumen, Inflammation, Suppurative     |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                             2            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3                                                                        |             
      Congestion                           | 2                                                           3            |             
      Cyst                                 |                                                                          |             
      Fibrosis                             | 3                                      3                                 |             
      Hydronephrosis                       |                                        3           2                     |             
      Hyperplasia, Lymphoid                |                                              3                           |             
      Infarct                              |                                  4                                       |             
      Inflammation, Chronic                | 3                                                                        |             
      Inflammation, Suppurative            |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 1| 1| 3| 3| 2| 3| 3| 3| 3| 5| 4| 9| 1| 3| 0| 3| 3| 3| 3| 8| 0| 3| 3| 3|             
                                           | 1| 9| 9| 6| 6| 5| 1| 3| 6| 6| 7| 2| 7| 9| 6| 4| 3| 3| 6| 6| 4| 0| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    8 MG/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |    1  1  1  1  2  1  1     1  1     1     1  1  1  3  1  1     1  1  1  1|             
      Nephropathy                          | 4  1     1  1  1  3  1  1  1        1  4  1     2     1  1        1  1  1|             
      Thrombosis                           |                                                                          |             
      Renal Tubule, Dilatation             | 2                                                  3                     |             
      Renal Tubule, Vacuolization          |                                                                          |             
          Cytoplasmic                      |                   3                                                      |             
                                            __________________________________________________________________________|             
   Ureter                                  |       +                                            +                     |             
      Mineralization                       |                                                    3                     |             
      Necrosis                             |                                                    3                     |             
      Serosa, Hyperplasia, Lymphoid        |       3                                                                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 5| 5| 7| 7| 2| 7| 7| 7| 7| 0| 5| 7| 7| 7| 4| 6| 6| 7| 7| 4| 6| 6| 7| 7|            |
                             DAY ON TEST   | 2| 0| 4| 3| 3| 5| 2| 2| 3| 3| 1| 5| 2| 3| 3| 4| 1| 9| 3| 2| 4| 6| 9| 1| 3|            |
                                           | 1| 8| 9| 7| 7| 0| 3| 4| 7| 7| 6| 6| 5| 3| 7| 4| 2| 8| 7| 3| 4| 3| 0| 8| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    8 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Perforation                          | 4                             4                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                   2                                                      |      1  2.0|
      Mucosa, Hyperplasia, Papillary       |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoid Tissue, Hyperplasia,        |                                                                          |            |
          Lymphoid                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     |                                                                          |      1  2.0|
      Clear Cell Focus                     |                                                                          |      1     |
      Congestion                           |                3                                                         |      1  3.0|
      Cyst                                 |                                                                          |      1  3.0|
      Cyst, Multiple                       |                                                                          |      1  3.0|
      Degeneration, Cystic                 |                                  2                                       |      1  2.0|
      Depletion Glycogen                   | 2                                                                        |      1  2.0|
      Eosinophilic Focus                   |                                                          2               |      1  2.0|
      Hyperplasia, Lymphoid                |          2  1     2     2  2        2              1  1  1           2  2|     24  1.5|
      Hyperplasia, Multifocal              |    2  3  2  2     2  2  2  2        2  3  2  2     2  2  2  1  2  2  2  2|     44  2.0|
      Infarct                              |    4                                                           4         |     13  3.0|
      Infiltration Cellular, Mixed Cell    |    1  2           1  1           2  1  2           1  1  1  2  2  2      |     23  1.6|
      Inflammation, Multifocal             |             1           1           1                 1                  |      7  1.0|
      Mixed Cell Focus                     |                         2                          3  2                  |      5  2.2|
      Necrosis, Multifocal                 |                   2                       1                              |      2  1.5|
      Thrombosis                           |                                                                4     4   |      4  3.5|
      Vacuolization Cytoplasmic            |    1     2  2     1     2  2        2  2                       2  1     2|     24  1.8|
      Biliary Tract, Fibrosis              |    2  3  2  1     1  1  2  1     1  2  2  1  2  2  2  2  2  1  2  1  2  1|     45  1.8|
      Biliary Tract, Hyperplasia           |    2  3  2  1     1  1  2  1     1  2  2  1  2  2  2  2  2  1  3  1  2  1|     46  1.8|
      Biliary Tract, Inflammation, Chronic |    1  2  2  1     1  1  1  1     1  1  2  1  2     1  1  1  1  2  1  1  1|     44  1.3|
      Centrilobular, Necrosis              |                                  3     3        3                        |      3  3.0|
      Hepatocyte, Cytomegaly               |    2  2  2  2     2  2  2  2     2  2  2  2  2     2  2  2  1  2  2  2  2|     45  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 5| 5| 7| 7| 2| 7| 7| 7| 7| 0| 5| 7| 7| 7| 4| 6| 6| 7| 7| 4| 6| 6| 7| 7|            |
                             DAY ON TEST   | 2| 0| 4| 3| 3| 5| 2| 2| 3| 3| 1| 5| 2| 3| 3| 4| 1| 9| 3| 2| 4| 6| 9| 1| 3|            |
                                           | 1| 8| 9| 7| 7| 0| 3| 4| 7| 7| 6| 6| 5| 3| 7| 4| 2| 8| 7| 3| 4| 3| 0| 8| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    8 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hepatocyte, Degeneration             |    2  2  2  2     1  2  2  2        2  3  2  2     2  2  2  2  2  2  2  2|     43  1.9|
      Hepatocyte, Mitotic Alteration       |                                                                          |      1  2.0|
      Hepatocyte, Necrosis                 |    3  1  1           1  1  1        1  3  2  2     2  1  2  1  2  2  1  1|     39  1.4|
      Kupffer Cell, Pigmentation           |    1  1  1        1  1  1  1     1  1  2  1  2     1  1  1  1  1  1  2  1|     43  1.2|
      Parenchyma, Atrophy, Multifocal      |    2  3  3  2     2  2  1  2     2  3  3  2  2  2  2  2  2  1  3  2  2  1|     45  2.1|
      Serosa, Fibrosis, Focal              |                2                                                         |      1  2.0|
      Serosa, Pigmentation, Focal          |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                          +                             +     +   |  10        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Infarct                              |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy, Focal                       |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                            1                          2                  |      3  1.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |                                           1                             1|      4  1.5|
      Adventitia, Inflammation, Chronic    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Focal                  |             1                       1     1              1  1            |     13  1.3|
      Mineralization, Focal                |                                              3                           |      1  3.0|
      Mucosa, Edema                        |                                                                2         |      1  2.0|
      Mucosa, Erosion                      |             1                                                            |      5  1.8|
      Mucosa, Hyperplasia, Papillary       |             1                       1     2              1  2            |     14  1.6|
      Mucosa, Ulcer                        |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Focal                  |    1              1        2                 2                           |      6  1.7|
      Mineralization                       |                                        1                                 |      3  1.7|
      Epithelium, Degeneration, Hyaline    |                                                                          |      2  1.5|
      Epithelium, Metaplasia, Squamous     |                                        1                                 |      1  1.0|
      Mucosa, Cyst                         |                                     2                                    |      1  2.0|
      Mucosa, Cyst, Multiple               |                            2                                             |      1  2.0|
      Mucosa, Erosion                      |    1                                                                     |      1  1.0|
      Mucosa, Hyperplasia                  |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |          +  +     +  +     +     +     +  +  +  +  +  +  +        +  +   |  36        |
      Incisor, Dysplasia                   |          1  1     1  3     1           1  1  1  1  1  3  1        2  1   |     35  1.5|
      Incisor, Inflammation, Suppurative   |                      2                                4                  |      3  3.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 5| 5| 7| 7| 2| 7| 7| 7| 7| 0| 5| 7| 7| 7| 4| 6| 6| 7| 7| 4| 6| 6| 7| 7|            |
                             DAY ON TEST   | 2| 0| 4| 3| 3| 5| 2| 2| 3| 3| 1| 5| 2| 3| 3| 4| 1| 9| 3| 2| 4| 6| 9| 1| 3|            |
                                           | 1| 8| 9| 7| 7| 0| 3| 4| 7| 7| 6| 6| 5| 3| 7| 4| 2| 8| 7| 3| 4| 3| 0| 8| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    8 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                           +                              |   2        |
      Aorta, Mineralization                |                                                                          |      1  3.0|
      Mesenteric Artery, Inflammation,     |                                                                          |            |
           Chronic                         |                                           3                              |      1  3.0|
      Renal Artery, Mineralization         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Focal Cellular Change                |                1                                                         |      1  1.0|
      Hyperplasia                          |                            3                                             |      1  3.0|
      Subcapsular, Hyperplasia, Focal      |                                                                          |      2  1.5|
      Subcapsular, Hyperplasia             |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                                          |      3  2.0|
      Hyperplasia                          |             2                                                            |      3  2.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|  48        |
      Cyst, Multiple                       |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  M  +  +  M  I  +  M  +  +|  44        |
      Pars Distalis, Angiectasis           |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |                                                                          |      1  1.0|
      Pars Distalis, Hyperplasia, Focal    | 1                                                                        |      1  1.0|
      Pars Nervosa, Angiectasis            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                         2              1                             2   |      7  1.6|
      Degeneration                         |       2                                                                  |      1  2.0|
      Follicular Cell, Hyperplasia         |                                                                         1|      4  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
      Dilatation                           |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 5| 5| 7| 7| 2| 7| 7| 7| 7| 0| 5| 7| 7| 7| 4| 6| 6| 7| 7| 4| 6| 6| 7| 7|            |
                             DAY ON TEST   | 2| 0| 4| 3| 3| 5| 2| 2| 3| 3| 1| 5| 2| 3| 3| 4| 1| 9| 3| 2| 4| 6| 9| 1| 3|            |
                                           | 1| 8| 9| 7| 7| 0| 3| 4| 7| 7| 6| 6| 5| 3| 7| 4| 2| 8| 7| 3| 4| 3| 0| 8| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    8 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Adenomatous             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ductus Deferens                         |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma                            |                2                                                         |      1  2.0|
      Granuloma Sperm                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   6        |
      Degeneration, Cystic                 |                                                                          |      4  2.5|
      Fibrosis                             |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Dilatation                           |                                                                          |      1  2.0|
      Edema                                |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                        1                                 |      4  1.8|
      Germinal Epithelium, Degeneration    |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                        +              +                  |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  M  M  M  +  +  +  +  +  +  M  M  M  +  +  +  +  M  +  +  +  M  M  +  M|  27        |
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +|  48        |
      Hyperplasia, Lymphoid                |                         2                                                |      4  2.3|
      Hyperplasia                          |                                                                          |      1  3.0|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  M  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Hyperplasia, Lymphoid                |                         2                                                |      5  2.2|
      Hyperplasia                          |                                                 1                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                 2           3  4         |      7  2.4|
      Hyperplasia, Lymphoid                |                         2                                                |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Depletion Lymphoid                   |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                        3        3  3  3  2               |     11  2.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  67                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 5| 5| 7| 7| 2| 7| 7| 7| 7| 0| 5| 7| 7| 7| 4| 6| 6| 7| 7| 4| 6| 6| 7| 7|            |
                             DAY ON TEST   | 2| 0| 4| 3| 3| 5| 2| 2| 3| 3| 1| 5| 2| 3| 3| 4| 1| 9| 3| 2| 4| 6| 9| 1| 3|            |
                                           | 1| 8| 9| 7| 7| 0| 3| 4| 7| 7| 6| 6| 5| 3| 7| 4| 2| 8| 7| 3| 4| 3| 0| 8| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    8 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                |             2     2     2                                2               |      7  2.1|
      Red Pulp, Depletion Cellular         |                                                                1         |      2  1.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  44        |
      Depletion Lymphoid                   |                                        2                                 |      4  1.8|
      Hyperplasia, Lymphoid                |                                        2                                 |      3  2.3|
      Epithelial Cell, Hyperplasia         |                                                       2                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                           2  2        3  2               |      6  2.0|
      Ulcer                                |                                                       3                  |      2  2.5|
      Prepuce, Fibrosis                    |                                                                          |      1  3.0|
      Subcutaneous Tissue, Congestion      |                                                 3                        |      1  3.0|
      Subcutaneous Tissue, Edema           |                                                                3         |      2  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                          |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Suppurative                     |                                                                          |      1  4.0|
      Subcutaneous Tissue, Head,           |                                                                          |            |
          Hyperplasia, Mast Cell           |                                        1                                 |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Distal, Joint, Femur, Arthrosis      |                         2                             2           2      |      5  2.6|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                  +                                       |   3        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                2              2                                          |      4  2.3|
      Hyperplasia, Lymphoid                |             2     1     2  1        1     2        1  2     1           1|     20  1.4|
      Hyperplasia, Macrophage              |                   1              2  1     2                              |     12  1.5|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      3  2.0|
      Mediastinum, Foreign Body            | 4                             2                                          |      2  3.0|
      Mediastinum, Inflammation,           |                                                                          |            |
          Suppurative                      | 4                             4                                          |      2  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  68                                                               
NTP Experiment-Test: 05004-04                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:03:20  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 5| 5| 7| 7| 2| 7| 7| 7| 7| 0| 5| 7| 7| 7| 4| 6| 6| 7| 7| 4| 6| 6| 7| 7|            |
                             DAY ON TEST   | 2| 0| 4| 3| 3| 5| 2| 2| 3| 3| 1| 5| 2| 3| 3| 4| 1| 9| 3| 2| 4| 6| 9| 1| 3|            |
                                           | 1| 8| 9| 7| 7| 0| 3| 4| 7| 7| 6| 6| 5| 3| 7| 4| 2| 8| 7| 3| 4| 3| 0| 8| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    8 MG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Pleura, Inflammation, Suppurative    | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lumen, Exudate                       |             2                       1              1           1  1      |      9  1.6|
      Lumen, Foreign Body                  |             2  2     2              1              1           2  1      |     13  1.7|
      Lumen, Inflammation, Suppurative     |                2                 2                                       |      2  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                 2                        |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                  +                                       |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                  +     +                       +  +      |   5        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Congestion                           |                3                                                         |      3  2.7|
      Cyst                                 |                                                 X                        |      1     |
      Fibrosis                             |                                                                          |      2  3.0|
      Hydronephrosis                       |                                                             2            |      3  2.3|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Infarct                              |                                                 4                        |      2  4.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                 2                        |      1  2.0|
      Metaplasia, Osseous                  |          2                                                               |      1  2.0|
      Mineralization                       |       1  2  1     1  1  1  1     1     1           1  1  1           1  1|     34  1.1|
      Nephropathy                          |    4     2  2     1  1  1  1        3  1  2  1        1  1  4  2  1  1  1|     36  1.6|
      Thrombosis                           |                                                 X                        |      1     |
      Renal Tubule, Dilatation             |                                                                          |      2  2.5|
      Renal Tubule, Vacuolization          |                                                                          |            |
          Cytoplasmic                      |                                  2                                       |      2  2.5|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   2        |
      Mineralization                       |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  3.0|
      Serosa, Hyperplasia, Lymphoid        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.