National Toxicology Program

National Toxicology Program
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TDMS Study 05004-04 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Southern Research Inst                                    DATE: 09/03/94   
EXP: 05004                          FURAN                      TIME: 03:04:09   
TEST: 04              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 56202    
CONT: NO1CP9565101                                             CAS: 110-00-9    
PATHOLOGIST: D. FARNELL                      S. EUSTIS                          
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NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Southern Research Inst                                    DATE: 09/03/94  
EXP: 05004                          FURAN                      TIME: 03:04:09  
TEST: 04              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 56202   
CONT: NO1CP9565101                                             CAS: 110-00-9   
PATHOLOGIST: D. FARNELL                      S. EUSTIS                         

                                       FURAN


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 736 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = VEHICLE CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 17     CENSORED DEATHS 0    TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      499   514   542   550   638   660   676   697   697   704                 |
 |      715   715   723   723   723   726   726                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 8. MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 30     CENSORED DEATHS 3    TERMINAL 17        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      444   444   508   549   556   557   584   600   612   642                 |
 |      663   690   697   698   701   704   718   719   719   719                 |
 |      723   723   724   725   725   731   733   733   733   733                 |
 |  CENSORED DEATHS                                                               |
 |      16    21    250                                                           |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 15.     MG/KG                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 49     UNCENSORED DEATHS 33     CENSORED DEATHS 0    TERMINAL 16        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      423   498   556   556   577   595   610   612   621   621                 |
 |      641   642   649   663   689   691   716   718   718   718                 |
 |      718   722   723   724   724   724   725   725   726   731                 |
 |      731   731   733                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                       FURAN


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 736 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   736 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE    |   100.0 100.0 100.0 100.0 100.0 100.0  94.0  92.0  88.0  66.0      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |8. MG/KG   |   100.0 100.0 100.0 100.0 100.0  95.7  93.6  83.0  76.6  36.2      |
 |           |                                                                    |
 |           |                                                                    |
 |15.        |   100.0 100.0 100.0 100.0  98.0  98.0  95.9  87.8  71.4  32.7      |
 |MG/KG      |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                VEHICLE          8. MG/KG         15.           |
 |                                CONTROL                           MG/KG         |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       66.0%            36.2%            32.7%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.002          P=0.009          P=0.003       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       660.5            660.2            665.2         |
 |NATURAL DEATHS (C)      |       (19.7)           (16.3)           (13.6)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       710.3            652.1            688.3         |
 |(STANDARD ERROR)        |       ( 8.3)           (23.2)           (10.3)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                       FURAN


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 736 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = VEHICLE CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 21     CENSORED DEATHS 0    TERMINAL 29        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      414   430   485   494   534   557   557   623   642   646                 |
 |      680   680   690   695   698   709   713   718   724   724                 |
 |      725                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 8. MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 25     CENSORED DEATHS 0    TERMINAL 25        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      330   446   479   499   592   627   638   642   642   646                 |
 |      673   686   688   695   701   702   703   715   716   717                 |
 |      721   724   725   728   733                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 15.     MG/KG                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 49     UNCENSORED DEATHS 46     CENSORED DEATHS 1    TERMINAL 2         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      360   456   475   513   514   517   540   541   542   549                 |
 |      562   570   577   586   586   601   621   621   632   642                 |
 |      652   652   659   659   676   685   695   701   701   709                 |
 |      712   715   716   716   717   717   717   717   719   719                 |
 |      723   724   724   725   731   733                                         |
 |  CENSORED DEATHS                                                               |
 |      625                                                                       |
 |                                                                                |
 ==================================================================================

                                       FURAN


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 736 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   736 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE    |   100.0 100.0 100.0 100.0  98.0  94.0  90.0  86.0  80.0  58.0      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |8. MG/KG   |   100.0 100.0 100.0  98.0  98.0  94.0  92.0  90.0  80.0  50.0      |
 |           |                                                                    |
 |           |                                                                    |
 |15.        |   100.0 100.0 100.0  98.0  98.0  93.9  81.6  67.3  50.6   4.2      |
 |MG/KG      |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                VEHICLE          8. MG/KG         15.           |
 |                                CONTROL                           MG/KG         |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       58.0%            50.0%             4.2%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P<0.001          P=0.622          P<0.001       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       625.6            646.7            637.4         |
 |NATURAL DEATHS (C)      |       (22.4)           (20.6)           (13.4)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       689.6            691.4            641.1         |
 |(STANDARD ERROR)        |       (12.1)           (12.0)           (12.9)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                               FURAN
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE CONTROL  = 1
                                                        8. MG/KG         = 2
                                                        15.     MG/KG    = 3

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                                                  3  2        1
      |                                                                    3           1 1
      |                                                                       2        321    113
      |                                                                                 2      12  3         1
   90 +                                                                                            3  3      1   1
      |                                                                                         2   2 3  3       1 1
P     |                                                                                             2  2           1  1
E     |                                                                                                2 23           11
R  80 +                                                                                                  23  2         1 1
C     |                                                                                                      2   2   2
E     |                                                                                                      33      22  11
N     |                                                                                                       3  3   3
T  70 +                                                                                                               22
      |                                                                                                              3   3
S     |                                                                                                                2 21  1
U     |
R  60 +
V     |                                                                                                                  22
I     |
V     |
A  50 +
L     |                                                                                                                   2 2
      |
      |
   40 +                                                                                                                   3 3
      |
      |                                                                                                                     22
      |                                                                                                                     33
   30 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 13 obs hidden.

                                                               FURAN
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE CONTROL  = 1
                                                        8. MG/KG         = 2
                                                        15.     MG/KG    = 3

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                                    2   3        1
      |                                                      2   3        1 1 2  3
      |                                                                     1 2  3 32112 3
      |                                                                               12     1        2
   90 +                                                                                      1  1     2    2
      |                                                                                  3    3            2 2
      |                                                                                         1         1  1
      |                                                                                       33             11
   80 +                                                                                        3 3            1    21
      |                                                                                          33                22
      |                                                                                           33                111
      |                                                                                            33                 22
P  70 +                                                                                             3  3              1 1
E     |                                                                                                3  3
R     |                                                                                                                2111
C     |                                                                                                   3 3
E  60 +                                                                                                     33 3
N     |                                                                                                                  21  1
T     |                                                                                                        3 3
      |                                                                                                                   2 2
S  50 +                                                                                                          3 3        22
U     |                                                                                                            33 3
R     |                                                                                                               33
V     |
I  40 +                                                                                                                33
V     |
A     |                                                                                                                 33
L     |
   30 +
      |
      |
      |
   20 +
      |                                                                                                                  33
      |
      |
   10 +
      |                                                                                                                   3 3
      |                                                                                                                     33
      |
    0 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 19 obs hidden.

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