National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3088

TDMS Study 05004-03 Pathology Tables

NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97
Route: GAVAGE                                                                                                     Time: 08:02:07




       Facility:  Southern Research Institute

       Chemical CAS #:  110-00-9

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 5| 2| 2| 2| 8| 2| 2| 2| 2| 0| 8| 2| 3| 3| 7| 8| 1| 3| 3| 9| 3| 3| 3| 3|             
                                           | 8| 6| 9| 9| 9| 4| 9| 9| 9| 9| 5| 8| 9| 0| 0| 0| 8| 4| 0| 0| 5| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                   2      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             2                          2        2                       2|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |       X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     |                                        X                                 |             
      Developmental Malformation           |                            X                       2  X                  |             
      Eosinophilic Focus                   |             X  X                                   X  X     X  X         |             
      Granuloma, Multiple                  |                      1                                               2  1|             
      Necrosis, Focal                      |                2                                                         |             
      Biliary Tract, Proliferation         | 2  2  2  2     2              3        1                    3     1      |             
      Centrilobular, Necrosis              |    2                          2                    2        2            |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                 +                          +     +  +            |             
      Inflammation, Chronic, Diffuse       |                                                                          |             
      Fat, Necrosis, Focal                 |       4                 4                          4                     |             
      Fat, Necrosis, Multifocal            |                                                          4  4            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                   2                                                      |             
      Atrophy, Multifocal                  |             2                                                            |             
      Hyperplasia, Focal                   |                                           2           2              2   |             
      Hyperplasia, Multifocal              |                   3                                                      |             
      Acinus, Atrophy                      |                                                    1                     |             
      Acinus, Hyperplasia                  |                                                    2                     |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema, Diffuse                       |                                                                          |             
      Ulcer                                |                                  3                                       |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 5| 2| 2| 2| 8| 2| 2| 2| 2| 0| 8| 2| 3| 3| 7| 8| 1| 3| 3| 9| 3| 3| 3| 3|             
                                           | 8| 6| 9| 9| 9| 4| 9| 9| 9| 9| 5| 8| 9| 0| 0| 0| 8| 4| 0| 0| 5| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Aorta, Inflammation, Chronic         |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |          1           1     2           1        1     2  2               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Angiectasis                          |                                                          2               |             
      Focal Cellular Change                | X              X        X                          X     X           X   |             
      Hypertrophy, Focal                   |                                                                2         |             
      Necrosis, Diffuse                    |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Vacuolization Cytoplasmic, Multifocal|                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Necrosis, Diffuse                    |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 3  2              2  3        3  3  2  3  3  4  3     3  3  2           2|             
      Pars Distalis, Cyst                  |          X        X     X           X                       X     X     X|             
      Pars Distalis, Hyperplasia, Focal    |       2                    2                             3               |             
      Pars Distalis, Hyperplasia           |                                                                          |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |       2              2                 2  2           2                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia, Focal           |       2                 1                 1           2                  |             
      C-Cell, Hyperplasia, Multifocal      |                                                    1        1           2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          3                       2                                       |             
      Inflammation, Acute, Focal,          |                                                                          |             
          Suppurative                      |                                                                         3|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                X              X                 X     X           X     X|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |          1                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 5| 2| 2| 2| 8| 2| 2| 2| 2| 0| 8| 2| 3| 3| 7| 8| 1| 3| 3| 9| 3| 3| 3| 3|             
                                           | 8| 6| 9| 9| 9| 4| 9| 9| 9| 9| 5| 8| 9| 0| 0| 0| 8| 4| 0| 0| 5| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |                      X                                            X      |             
      Hydrometra                           |                                                                          |             
      Hyperplasia, Cystic                  |                                                                          |             
      Inflammation, Acute                  |                                                    2                     |             
      Inflammation, Acute, Suppurative     |                                                                          |             
      Cervix, Cyst                         |                                                                          |             
      Cervix, Cyst, Multiple               |             X                                                            |             
      Cervix, Hypertrophy                  |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +                                                        +            |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  M  +  M  M  +  M  M  +  +  M  +  M  +  +  +  +  +  M  +  M  +  M  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |             2                                      2                     |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute, Suppurative     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                       2                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Fibrosis, Focal                      |                               2                             3            |             
      Hematopoietic Cell Proliferation     |             3     2     2                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             X                                                            |             
      Fat, Mediastinum, Inflammation,      |                                                                          |             
          Chronic                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Cyst                           | X  X  X  X  X     X  X  X  X  X  X     X  X  X  X  X  X  X  X  X  X     X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Hypertrophy, Focal          |                                                                2         |             
      Femur, Hypertrophy, Focal            |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 4| 6| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 5| 2| 2| 2| 8| 2| 2| 2| 2| 0| 8| 2| 3| 3| 7| 8| 1| 3| 3| 9| 3| 3| 3| 3|             
                                           | 8| 6| 9| 9| 9| 4| 9| 9| 9| 9| 5| 8| 9| 0| 0| 0| 8| 4| 0| 0| 5| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          | 2                                               2                        |             
      Degeneration, Multifocal             |                                                    4                     |             
      Hemorrhage, Multifocal               |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                              2                           |             
      Foreign Body                         |                                                                          |             
      Granuloma, Multiple                  |             1        2     2                       2              1     1|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Histiocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Histiocyte                      |                                                                          |             
      Pigmentation, Focal, Cholesterol     |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                       3                  |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |                                                                          |             
      Fat, Mediastinum, Necrosis,          |                                                                          |             
          Multifocal                       |       2                                                  2               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute, Suppurative              |    2                                                                     |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Subacute                        |                                                                1         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                                                                        |             
      Cataract                             | 3                                                                        |             
      Inflammation, Subacute               |                                                                          |             
      Retina, Degeneration                 | 3                                                                        |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +           +                                                   |             
      Inflammation, Chronic, Focal         |          1           2                                                   |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Multilocular                    |                                                                          |             
      Nephropathy, Chronic                 | 3     2  1                       3        1     1     2                 1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 8| 3| 3| 3| 0| 3| 2| 3| 3| 5| 6| 6| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 0| 0| 0| 0| 0| 9| 7| 0| 0| 1| 5| 7| 9| 1| 1| 5| 5| 6| 1| 1| 1| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  49        |
      Parasite Metazoan                    |          2  2        2                                                   |      3  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                 2                        |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                                                      X   |      5  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X  X  X  X  X  X        X  X  X  X  X  X  X  X        X  X  X  X  X  X  X|     43     |
      Clear Cell Focus                     |                                                                          |      1     |
      Developmental Malformation           |    X                       2        2  2  2                    X         |      9  2.0|
      Eosinophilic Focus                   |       X  X        X                    X  X  X        X     X  X  X  X   |     17     |
      Granuloma, Multiple                  |    2     2  1                 1                          2  2     1      |     10  1.5|
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Biliary Tract, Proliferation         |                   2                                3                     |     11  2.1|
      Centrilobular, Necrosis              |                2  2                             1  2                     |      8  1.9|
      Serosa, Inflammation, Chronic        | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                 +     +                                                |   8        |
      Inflammation, Chronic, Diffuse       | 3                                                                        |      1  3.0|
      Fat, Necrosis, Focal                 | 4                 4     4                                                |      6  4.0|
      Fat, Necrosis, Multifocal            |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy, Focal                       |                               2              2                 2         |      4  2.0|
      Atrophy, Multifocal                  |    2              2                                                      |      3  2.0|
      Hyperplasia, Focal                   |             2                                                            |      4  2.0|
      Hyperplasia, Multifocal              |                                                                          |      1  3.0|
      Acinus, Atrophy                      |                                                                          |      1  1.0|
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                               +                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema, Diffuse                       |                                                 2                        |      1  2.0|
      Ulcer                                |                                                 4                        |      2  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 8| 3| 3| 3| 0| 3| 2| 3| 3| 5| 6| 6| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 0| 0| 0| 0| 0| 9| 7| 0| 0| 1| 5| 7| 9| 1| 1| 5| 5| 6| 1| 1| 1| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                        2                                 |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +                                                                        |   1        |
      Aorta, Inflammation, Chronic         | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |    1     1     1                    1  1     2        1     1  1     1   |     17  1.2|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                            X                                             |      1     |
      Angiectasis                          |                                                             2           2|      3  2.0|
      Focal Cellular Change                |    X                                               X                 X   |      9     |
      Hypertrophy, Focal                   |                                                                          |      1  2.0|
      Necrosis, Diffuse                    |                                  4                                       |      1  4.0|
      Vacuolization Cytoplasmic, Diffuse   |                                                 3                        |      1  3.0|
      Vacuolization Cytoplasmic, Focal     |    2                                                                     |      1  2.0|
      Vacuolization Cytoplasmic, Multifocal|                                                             3            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |          2                                                               |      1  2.0|
      Necrosis, Diffuse                    |                                  4                                       |      1  4.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           | 2  2  3  2  1  3        2  2  3     3  2  2  2           3     3  3      |     31  2.5|
      Pars Distalis, Cyst                  |    X              X  X  X  X           X  X           X  X           X  X|     18     |
      Pars Distalis, Hyperplasia, Focal    |             2     2  2     3           2                                2|      9  2.2|
      Pars Distalis, Hyperplasia           |    2                                      2                              |      2  2.0|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |                      2  1     2                          2     2  2      |     11  1.9|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ultimobranchial Cyst                 |                                                                X         |      1     |
      C-Cell, Hyperplasia, Focal           | 2                                      2                    2            |      7  1.7|
      C-Cell, Hyperplasia, Multifocal      |          2  2                                                            |      5  1.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 8| 3| 3| 3| 0| 3| 2| 3| 3| 5| 6| 6| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 0| 0| 0| 0| 0| 9| 7| 0| 0| 1| 5| 7| 9| 1| 1| 5| 5| 6| 1| 1| 1| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  M  +  M  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  M  +  +  +  +|  43        |
      Hyperplasia                          |       2                                2                                 |      4  2.3|
      Inflammation, Acute, Focal,          |                                                                          |            |
          Suppurative                      |                                                                3         |      2  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 | X  X  X  X           X                                      X            |     12     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |                                                                          |      1  1.0|
      Cyst                                 |                                                                          |      2     |
      Hydrometra                           |                            2           3                                 |      2  2.5|
      Hyperplasia, Cystic                  |                            2                                             |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Acute, Suppurative     |                                                                         1|      1  1.0|
      Cervix, Cyst                         |                   X                                                      |      1     |
      Cervix, Cyst, Multiple               |                                                                          |      1     |
      Cervix, Hypertrophy                  |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |             +                             +                              |   2        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  M  +  +  M  +  +  M  +  +  +  +  +  +  M  M  +  M  M  M  M  +  M  M|  27        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  47        |
      Ectasia                              |                                     3                                    |      3  2.3|
      Hyperplasia                          |                               2                                          |      1  2.0|
      Inflammation, Acute, Suppurative     |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  48        |
      Congestion                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                      1           1                                       |      2  1.0|
      Fibrosis, Focal                      |                                                    2                     |      3  2.3|
      Hematopoietic Cell Proliferation     |    2           3                    2        3                    3      |      8  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Cyst                                 |                                                                          |      1     |
      Fat, Mediastinum, Inflammation,      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 8| 3| 3| 3| 0| 3| 2| 3| 3| 5| 6| 6| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 0| 0| 0| 0| 0| 9| 7| 0| 0| 1| 5| 7| 9| 1| 1| 5| 5| 6| 1| 1| 1| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Chronic                          | 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Duct, Cyst                           | X     X     X  X  X  X  X  X  X     X  X     X  X  X  X  X  X  X  X  X  X|     43     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                               2                                          |      1  2.0|
      Inflammation, Focal, Granulomatous   |                               3                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cranium, Hypertrophy, Focal          |       3                                                                  |      2  2.5|
      Femur, Hypertrophy, Focal            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                          |      2  2.0|
      Degeneration, Multifocal             |                                                                          |      1  4.0|
      Hemorrhage, Multifocal               |                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                 +                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  2.0|
      Foreign Body                         |                                           2                              |      1  2.0|
      Granuloma, Multiple                  |       2                 2  1     1        2           2                  |     12  1.6|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Histiocyte                       |                                                       2                  |      1  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Histiocyte                      |                                           2                              |      1  2.0|
      Pigmentation, Focal, Cholesterol     |                                                       2                  |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |             3           2                             2                  |      4  2.5|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Multifocal                      |                                           3                              |      1  3.0|
      Fat, Mediastinum, Necrosis,          |                                                                          |            |
          Multifocal                       |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 8| 3| 3| 3| 0| 3| 2| 3| 3| 5| 6| 6| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 0| 0| 0| 0| 0| 9| 7| 0| 0| 1| 5| 7| 9| 1| 1| 5| 5| 6| 1| 1| 1| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Acute, Suppurative              |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Subacute                        |                   2           2                 3                        |      4  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                               +                                          |   2        |
      Cataract                             |                                                                          |      1  3.0|
      Inflammation, Subacute               |                               4                                          |      1  4.0|
      Retina, Degeneration                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
      Inflammation, Chronic, Focal         |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                               +                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                     +                                    |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Multilocular                    |          X                                                               |      1     |
      Nephropathy, Chronic                 |    1     2              1     1           1        1        2        1   |     16  1.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 1| 5| 6| 7| 7| 5| 6| 6| 6| 7| 4| 4| 6| 7| 7|             
                             DAY ON TEST   | 9| 4| 3| 3| 3| 9| 1| 6| 3| 3| 4| 3| 8| 3| 3| 2| 9| 9| 9| 3| 2| 5| 6| 1| 3|             
                                           | 6| 4| 0| 0| 0| 8| 3| 5| 1| 1| 3| 2| 9| 1| 1| 1| 6| 7| 8| 1| 4| 7| 4| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    8  MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                    2                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             2        2                    2              2               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             2           2                    2                           |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Multilocular                    |       X  X                 X           X  X     X  X                 X  X|             
      Developmental Malformation           |                         2     X                             2            |             
      Hemorrhage, Focal                    |                                                                         2|             
      Hemorrhage, Multifocal               |    2                                                                     |             
      Hyperplasia, Multifocal, Nodular     |                                                                          |             
      Neovascularization                   |          2        2                                                  2   |             
      Pigmentation, Hematoidin             |                                                                          |             
      Thrombosis                           |                                                                          |             
      Biliary Tract, Cyst, Multiple        | 4  4  4  4  4  4  4  4  4  4     4  4  4     4  4  4  4  4  4  3  4  4  4|             
      Biliary Tract, Fibrosis, Multifocal  | 4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  3  4  4  4  4  3  4  4  4  4|             
      Biliary Tract, Hyperplasia,          |                                                                          |             
          Multifocal                       | 4  4  4  4  4  4  4  4  4  4  2  4  4  4  4  4  4  4  4  4  4  4  4  4  4|             
      Biliary Tract, Inflammation, Chronic,|                                                                          |             
           Multifocal                      | 4  4  4  4  4  4  4  4  4  4  2  4  4  4  4  4  4  4  4  4  4  4  4  4  4|             
      Biliary Tract, Metaplasia            | 4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  3  3  4  4  4|             
      Centrilobular, Necrosis              |       2                       3                                          |             
      Hepatocyte, Cytomegaly               | 4  3  3  3  3  3  2  2  3  3  2  3  3  3  3  3  3  2  3  4  3  3  3  3  2|             
      Hepatocyte, Degeneration, Multifocal | 3  3  3  2  4  2  2  3  3  2     4  2  3  2  3  2  2  3  3  3  2  2  3  2|             
      Hepatocyte, Hyperplasia, Multifocal, |                                                                          |             
           Nodular                         | 4  4  4  4  4  4  4  4  4  4     4  4  4  4  4  4  4  4  4  4  4  4  4  4|             
      Hepatocyte, Necrosis, Multifocal     | 2  2  3  2  4  2  2  4  3  2     4  2  2  2  3  2  2  4  2  3  2  4  2  2|             
      Hepatocyte, Vacuolization Cytoplasmic| 3  3  3  2  4  4  2  2  3  3     3  4  4  4  3  3  2  3  4  3  2  2  3  4|             
      Kupffer Cell, Pigmentation,          |                                                                          |             
          Multifocal                       | 2  2  2  2  2  2  2  2  2  2     2  2  2  2  2  2  2  2  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                       +           +  +     +           +     +      |             
      Mineralization, Focal                |                            2                                             |             
      Fat, Necrosis, Focal                 |                            4           4  4     4           2            |             
      Fat, Necrosis, Multifocal            |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                         1|             
      Atrophy, Multifocal                  |                   1                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 1| 5| 6| 7| 7| 5| 6| 6| 6| 7| 4| 4| 6| 7| 7|             
                             DAY ON TEST   | 9| 4| 3| 3| 3| 9| 1| 6| 3| 3| 4| 3| 8| 3| 3| 2| 9| 9| 9| 3| 2| 5| 6| 1| 3|             
                                           | 6| 4| 0| 0| 0| 8| 3| 5| 1| 1| 3| 2| 9| 1| 1| 1| 6| 7| 8| 1| 4| 7| 4| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    8  MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Focal                   |                2                                                        2|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                        2                                 |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia                          |                                        2  2                              |             
      Hyperplasia, Squamous                |             2                                                            |             
      Inflammation, Subacute               |             2     2                    2  2                              |             
      Ulcer                                |                                        4  2                              |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Erosion, Multiple                    |                                                                   3      |             
      Mineralization, Multifocal           |                                  3                                       |             
      Ulcer                                |                                                                   3      |             
                                            __________________________________________________________________________|             
   Tongue                                  |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Abdominal, Hypertrophy               |                                                                          |             
      Abdominal, Inflammation, Subacute    |                                                                          |             
      Abdominal, Thrombosis                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1  2  2  1  2  1     2        3  1  2  2     1  2  1  1        2     1|             
      Mineralization, Multifocal           |                                  4                                       |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                         X                                                |             
      Focal Cellular Change                |                                                 X                    X   |             
      Hematopoietic Cell Proliferation     |                                                                   2      |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |    2  2                                                                  |             
      Hyperplasia, Multifocal              |          2                                                               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia                          |                         2  2        2     2     1                    2  2|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 2     3     3  2        2           3  3  3  2     3  3  2              1|             
      Pars Distalis, Cyst                  |          X     X        X  X        X           X                 X     X|             
      Pars Distalis, Hyperplasia, Focal    |    2     2  2  3  2  2  2  2        2        2  2              2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 1| 5| 6| 7| 7| 5| 6| 6| 6| 7| 4| 4| 6| 7| 7|             
                             DAY ON TEST   | 9| 4| 3| 3| 3| 9| 1| 6| 3| 3| 4| 3| 8| 3| 3| 2| 9| 9| 9| 3| 2| 5| 6| 1| 3|             
                                           | 6| 4| 0| 0| 0| 8| 3| 5| 1| 1| 3| 2| 9| 1| 1| 1| 6| 7| 8| 1| 4| 7| 4| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    8  MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Hyperplasia           |       2                                                                  |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |             2                       1              2  2  2              2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |             2                                2                           |             
      Follicle, Cyst                       |    X                             X                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute, Focal,          |                                                                          |             
          Suppurative                      |                            3                                             |             
      Duct, Cyst                           |                            X                                             |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      X                    X              X               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          X                                                        X      |             
      Hemorrhage                           |                                                                          |             
      Cervix, Cyst                         |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2  2  2     2  2        2        2     2  2     1                 2  2|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pancreatic, Ectasia                  | 3  3        4  3     2  3                    3  4  3  3        2        4|             
      Pancreatic, Hyperplasia              |                                              2                           |             
      Pancreatic, Necrosis                 |                                                                          |             
      Renal, Ectasia                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  M  M  +  +  +  +  +  +  +  +  M  +  M  +  M  M  +  +  +  +  +  M  M|             
      Ectasia                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  M  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +|             
      Ectasia                              |       2                                                                  |             
      Hyperplasia                          |                                                                         2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Ectasia                              |                                        2        1     3                 3|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                         2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |          2  2     2     2  2        2  2  3  3  2     2        2        2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 1| 5| 6| 7| 7| 5| 6| 6| 6| 7| 4| 4| 6| 7| 7|             
                             DAY ON TEST   | 9| 4| 3| 3| 3| 9| 1| 6| 3| 3| 4| 3| 8| 3| 3| 2| 9| 9| 9| 3| 2| 5| 6| 1| 3|             
                                           | 6| 4| 0| 0| 0| 8| 3| 5| 1| 1| 3| 2| 9| 1| 1| 1| 6| 7| 8| 1| 4| 7| 4| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    8  MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibrosis, Focal                      |    2                                                                     |             
      Hematopoietic Cell Proliferation     |          2  2     3  2  2  2        2  2              2           2  3  4|             
      Inflammation, Chronic, Focal         |                                                                          |             
      Necrosis, Diffuse                    |                                                                          |             
      Necrosis, Focal                      | 4                                                           4            |             
      Thrombosis                           | X                                                                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Cyst                           | X  X  X  X  X  X  X     X  X        X  X  X     X  X  X  X     X  X  X  X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Hypertrophy, Focal          |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Hemorrhage, Focal                    |                                                                          |             
      Hemorrhage, Multifocal               |                                                             2  2         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                2              3  2                                       |             
      Foreign Body                         |                               4                                          |             
      Granuloma, Multiple                  |    2                    1           2           1     2  2               |             
      Hemorrhage, Multifocal               |                                                             2           2|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Histiocyte                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Histiocyte                      |    2                                1                    2               |             
      Pigmentation, Focal, Cholesterol     |                                                          1               |             
      Pigmentation, Multifocal, Cholesterol|    2                                1                                    |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |    2                                                     1  2            |             
      Fat, Mediastinum, Necrosis,          |                                                                          |             
          Multifocal                       | 3                       2                                         2      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Fungus                               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 1| 5| 6| 7| 7| 5| 6| 6| 6| 7| 4| 4| 6| 7| 7|             
                             DAY ON TEST   | 9| 4| 3| 3| 3| 9| 1| 6| 3| 3| 4| 3| 8| 3| 3| 2| 9| 9| 9| 3| 2| 5| 6| 1| 3|             
                                           | 6| 4| 0| 0| 0| 8| 3| 5| 1| 1| 3| 2| 9| 1| 1| 1| 6| 7| 8| 1| 4| 7| 4| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    8  MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute, Suppurative     |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute, Suppurative              |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Subacute                        |                                                                   2     2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                              X                           |             
      Nephropathy, Chronic                 | 4  2  3  3  4  3  3  3  4  4     3  3  4  4     4  4  3  4  2  1  3  4  4|             
      Renal Tubule, Mineralization,        |                                                                          |             
          Multifocal                       |                                  3                                       |             
      Renal Tubule, Necrosis, Multifocal   |                                  3                                       |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 4| 5| 5| 6| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| 6| 6|            |
                             DAY ON TEST   | 3| 7| 1| 4| 6| 9| 3| 1| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 3| 7| 8| 2| 2| 6|            |
                                           | 9| 1| 1| 9| 3| 2| 3| 8| 1| 1| 8| 1| 1| 1| 1| 9| 1| 1| 1| 1| 5| 3| 3| 7| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    8  MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                              2     2                     |      6  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                            2                                             |      4  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Multilocular                    |                            X           X        X                        |     12     |
      Developmental Malformation           |                                                                          |      3  2.0|
      Hemorrhage, Focal                    |             2                                                            |      2  2.0|
      Hemorrhage, Multifocal               |                                                 2           2            |      3  2.0|
      Hyperplasia, Multifocal, Nodular     |                                                             4            |      1  4.0|
      Neovascularization                   |                         2              2  2  2        2                  |      8  2.0|
      Pigmentation, Hematoidin             |                                                             2            |      1  2.0|
      Thrombosis                           |                   X                                                      |      1     |
      Biliary Tract, Cyst, Multiple        |    3  4  4  4  4  4  4  4  4     4  4  4  4  4  4  4  4  4  4  4  4  4  4|     46  4.0|
      Biliary Tract, Fibrosis, Multifocal  | 4  3  4  4  4  4  4  4  4  4     4  4  4  4  4  4  4  4  4  4  4  4  4  4|     49  3.9|
      Biliary Tract, Hyperplasia,          |                                                                          |            |
          Multifocal                       | 4  3  4  4  4  4  4  4  4  4     4  4  4  4  4  4  4  4  4  4  4  4  4  4|     49  3.9|
      Biliary Tract, Inflammation, Chronic,|                                                                          |            |
           Multifocal                      | 2  3  4  4  4  4  4  4  4  4     4  4  4  4  4  4  4  4  4  4  4  4  4  4|     49  3.9|
      Biliary Tract, Metaplasia            | 2  3  4  4  4  4  4  4  4  4     4  4  4  4  4  4  4  4  4  4  4  4  4  4|     49  3.9|
      Centrilobular, Necrosis              |                                                                          |      2  2.5|
      Hepatocyte, Cytomegaly               | 2  3  4  3  3  3  3  3  3  3     3  3  3  3  3  3  3  3  3  3  3  4  4  4|     49  3.0|
      Hepatocyte, Degeneration, Multifocal |    3  4  2  2  3  3  2  3  3     4  3  3  2  3  3  3  3  2  4  2  4  3  3|     47  2.8|
      Hepatocyte, Hyperplasia, Multifocal, |                                                                          |            |
           Nodular                         |    3  4  4  4  4  4  4  4  4     4  4  4  4  4  4  4  4  4     4  4  4  4|     46  4.0|
      Hepatocyte, Necrosis, Multifocal     |    3  3  2  2  3  2  2  2  2     3  2  2  2  3  3  3  2  2  4  2  4  4  2|     47  2.6|
      Hepatocyte, Vacuolization Cytoplasmic|    3  4  2  3  3  3  3  4  3     4  4  3  3  3  3  3  4  4  3  3  3  2  4|     47  3.1|
      Kupffer Cell, Pigmentation,          |                                                                          |            |
          Multifocal                       | 2  2  2  2  2  2  2  2  2  2     2  2  2  2  2  2  2  2  2  2  2  2  2  2|     48  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +  +  +     +     +              +                        |  13        |
      Mineralization, Focal                |                      2                                                   |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 4| 5| 5| 6| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| 6| 6|            |
                             DAY ON TEST   | 3| 7| 1| 4| 6| 9| 3| 1| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 3| 7| 8| 2| 2| 6|            |
                                           | 9| 1| 1| 9| 3| 2| 3| 8| 1| 1| 8| 1| 1| 1| 1| 9| 1| 1| 1| 1| 5| 3| 3| 7| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    8  MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Fat, Necrosis, Focal                 |                      4     4                                             |      7  3.7|
      Fat, Necrosis, Multifocal            |                   4              4                                       |      2  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy, Focal                       |                                                       1                  |      2  1.0|
      Atrophy, Multifocal                  |                                                                          |      1  1.0|
      Hyperplasia, Focal                   |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |          3                                                               |      2  2.5|
      Hyperkeratosis                       | 2                                                                        |      1  2.0|
      Hyperplasia                          | 2        2                                                  2            |      5  2.0|
      Hyperplasia, Squamous                |                                                                          |      1  2.0|
      Inflammation, Subacute               |          3                                                  2            |      6  2.2|
      Ulcer                                |          3                                                               |      3  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |          2                                                               |      1  2.0|
      Erosion, Multiple                    |                                                                          |      1  3.0|
      Mineralization, Multifocal           |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                      +                                                   |   1        |
      Abdominal, Hypertrophy               |                      4                                                   |      1  4.0|
      Abdominal, Inflammation, Subacute    |                      3                                                   |      1  3.0|
      Abdominal, Thrombosis                |                      X                                                   |      1     |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |       2  1     2     2     2     1  2  1  2  1  2  2  1  1     1         |     32  1.6|
      Mineralization, Multifocal           |                                                                          |      1  4.0|
      Thrombosis                           |                   X                                                      |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                 X  X                     |      3     |
      Focal Cellular Change                |                                                                      X   |      3     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Diffuse   |    3                                                                     |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 4| 5| 5| 6| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| 6| 6|            |
                             DAY ON TEST   | 3| 7| 1| 4| 6| 9| 3| 1| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 3| 7| 8| 2| 2| 6|            |
                                           | 9| 1| 1| 9| 3| 2| 3| 8| 1| 1| 8| 1| 1| 1| 1| 9| 1| 1| 1| 1| 5| 3| 3| 7| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    8  MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  49        |
      Hyperplasia, Focal                   |                                                                          |      2  2.0|
      Hyperplasia, Multifocal              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  46        |
      Hyperplasia                          |                                              2           2               |      9  1.9|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  49        |
      Pars Distalis, Angiectasis           |          4  4        3     2        3           3  3     3     4         |     22  2.8|
      Pars Distalis, Cyst                  |       X     X     X  X           X  X  X  X  X  X        X           X   |     20     |
      Pars Distalis, Hyperplasia, Focal    |       3        2  2     2                 2              2               |     18  2.1|
      Pars Distalis, Hyperplasia           |                                        2                                 |      2  2.0|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |             2        2              2                          2         |     10  1.9|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia, Focal           |                   2     2  2           3                 2  2            |      8  2.1|
      Follicle, Cyst                       |                                                                          |      2     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  47        |
      Hyperplasia                          |                         2        2                                       |      2  2.0|
      Inflammation, Acute, Focal,          |                                                                          |            |
          Suppurative                      |                                  2                                       |      2  2.5|
      Duct, Cyst                           |                X                 X     X              X                  |      5     |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                      X     X                 X                           |      6     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      2     |
      Hemorrhage                           |                                              4                           |      1  4.0|
      Cervix, Cyst                         |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                            2     1     2  1        2  2  2  2  2  2  2  1|     24  1.8|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pancreatic, Ectasia                  |       3  4           2           2     4        3        3  4  4  4     3|     23  3.2|
      Pancreatic, Hyperplasia              |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 4| 5| 5| 6| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| 6| 6|            |
                             DAY ON TEST   | 3| 7| 1| 4| 6| 9| 3| 1| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 3| 7| 8| 2| 2| 6|            |
                                           | 9| 1| 1| 9| 3| 2| 3| 8| 1| 1| 8| 1| 1| 1| 1| 9| 1| 1| 1| 1| 5| 3| 3| 7| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    8  MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pancreatic, Necrosis                 |                                                                   1      |      1  1.0|
      Renal, Ectasia                       |                                              4                           |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  M  +  +  +  M  M  M  +  M  M  M  +  +  M  +  +  +  M  M  M  +|  30        |
      Ectasia                              |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Ectasia                              |                                        2                                 |      2  2.0|
      Hyperplasia                          |                                     2  2                                 |      3  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Congestion                           |                   3                       2                              |      2  2.5|
      Ectasia                              |                                           3  3  2        2  2           2|     10  2.3|
      Hyperplasia                          |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                     2                                    |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           | 1        2  2           2  2        2  2  2           2  2               |     23  2.0|
      Fibrosis, Focal                      |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |             2  3     4  2  3        2  3  2  4        2  2  3        4   |     25  2.6|
      Inflammation, Chronic, Focal         |                                                                   4      |      1  4.0|
      Necrosis, Diffuse                    |                                                                   1      |      1  1.0|
      Necrosis, Focal                      |                                                                          |      2  4.0|
      Thrombosis                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  +  +  M  +  +  M  +  +  +  +  M  M  +  +  +  +  +  +|  43        |
      Hemorrhage                           |                               2                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Duct, Cyst                           |    X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X  X  X  X  X  X  X|     43     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cranium, Hypertrophy, Focal          |                                              3           2               |      2  2.5|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |          2                                                     3         |      2  2.5|
      Hemorrhage, Focal                    |                   2                                                      |      1  2.0|
      Hemorrhage, Multifocal               |    4                                                                     |      3  2.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 4| 5| 5| 6| 5| 6| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| 6| 6| 6|            |
                             DAY ON TEST   | 3| 7| 1| 4| 6| 9| 3| 1| 3| 3| 3| 0| 3| 3| 3| 2| 3| 3| 3| 3| 7| 8| 2| 2| 6|            |
                                           | 9| 1| 1| 9| 3| 2| 3| 8| 1| 1| 8| 1| 1| 1| 1| 9| 1| 1| 1| 1| 5| 3| 3| 7| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    8  MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                2         |      4  2.3|
      Foreign Body                         |                               2                                          |      2  3.0|
      Granuloma, Multiple                  |    1  1                                   1              2  1            |     11  1.5|
      Hemorrhage, Multifocal               |                               2                                          |      3  2.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Histiocyte                       |                                  2                       2               |      2  2.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Histiocyte                      |                                                                          |      3  1.7|
      Pigmentation, Focal, Cholesterol     |                                  2                       2               |      3  1.7|
      Pigmentation, Multifocal, Cholesterol|                                                                          |      2  1.5|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                   2                                                      |      4  1.8|
      Fat, Mediastinum, Necrosis,          |                                                                          |            |
          Multifocal                       |             2                                                            |      4  2.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         | 3                                                           2            |      2  2.5|
      Fungus                               | 3                                                                 2      |      2  2.5|
      Inflammation, Acute, Suppurative     | 3                                                                 4      |      2  3.5|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute, Suppurative              |       2                                                                  |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Subacute                        |             3                                                            |      3  2.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                   +                                                      |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Developmental Malformation           |                                                                          |      1     |
      Nephropathy, Chronic                 |    2  2  4  4  3  3  4  4  4     3  4  4  4  4  4  3  4  4  3  4  2  3  3|     46  3.4|
      Renal Tubule, Mineralization,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  3.0|
      Renal Tubule, Necrosis, Multifocal   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 5| 5| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 5| 6| 7| 7|             
                             DAY ON TEST   | 2| 5| 3| 3| 3| 4| 5| 6| 3| 3| 2| 5| 0| 0| 2| 2| 3| 3| 3| 3| 8| 4| 8| 0| 3|             
                                           | 7| 4| 2| 2| 2| 1| 7| 1| 2| 2| 1| 5| 2| 3| 9| 9| 2| 2| 2| 2| 8| 9| 8| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    4  MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |          2                 2                    2  2     2              2|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |          X                                                               |             
      Cyst Multilocular                    |                                                                          |             
      Developmental Malformation           |                                              2  2                        |             
      Granuloma, Multiple                  |       2                                                        1        1|             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |       2  2  2  1                                2                    2   |             
      Hemorrhage, Focal                    |                         2                                                |             
      Hemorrhage, Multifocal               |          2                                                               |             
      Neovascularization                   |          2              2        2                                       |             
      Pigmentation, Hematoidin             |                                                          2               |             
      Pigmentation, Hemosiderin, Multifocal|                                                          2               |             
      Thrombosis                           |                                  X                                       |             
      Biliary Tract, Cyst, Multiple        | 3  4  4  3  4  3  3  4  3  4  2  4  4  4  4  3  4  4  3  4  2  3  4  3  4|             
      Biliary Tract, Fibrosis, Multifocal  | 4  4  4  4  3  3  4  4  4  4  2  4  4  4  4  4  4  4  4  4  2  3  4  4  4|             
      Biliary Tract, Hyperplasia,          |                                                                          |             
          Multifocal                       | 3  4  4  4  4  3  4  4  4  3  2  4  4  4  4  4  4  4  4  4  2  3  4  3  4|             
      Biliary Tract, Inflammation, Chronic,|                                                                          |             
           Multifocal                      | 3  4  4  4  3  3  4  4  4  3  2  4  4  4  4  3  4  4  4  4  2  3  4  3  4|             
      Biliary Tract, Metaplasia            | 3  4  4  4  4  3  4  4  4  4  3  4  4  4  4  3  4  4  4  4  3  3  4  3  4|             
      Centrilobular, Necrosis              |                               2     2                       2     2  3   |             
      Hepatocyte, Cytomegaly               | 2  2  3  2  3  3  3  2  2  2  2  2  4  2  2  3  2  3  3  2  2  2  3  2  2|             
      Hepatocyte, Degeneration, Multifocal | 2  2  2  2  2  2  2     2  2  2  2  2  3  2  3  2  3  2  2  2  2  2  2  2|             
      Hepatocyte, Hyperplasia, Multifocal, |                                                                          |             
           Nodular                         | 2  2  2  2  2  2  2  2  2  2  2  3  4  2  2  3  2  2  2  4     2  4  2  2|             
      Hepatocyte, Necrosis, Multifocal     | 2  2  2  2  2  2  2     2  2  2  2  2  2  2  3  2  3  2  4     2  2  2  2|             
      Hepatocyte, Vacuolization Cytoplasmic| 3  2  3  2  3  2  2  2  3  3  2  2  3  4  3  3  4  4  4  2  2  2  2  2  2|             
      Kupffer Cell, Pigmentation,          |                                                                          |             
          Multifocal                       | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                +  +  +                    +  +                           |             
      Mineralization, Focal                |                                                                          |             
      Fat, Necrosis, Focal                 |                4                          4                              |             
      Fat, Necrosis, Multifocal            |                      4                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 5| 5| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 5| 6| 7| 7|             
                             DAY ON TEST   | 2| 5| 3| 3| 3| 4| 5| 6| 3| 3| 2| 5| 0| 0| 2| 2| 3| 3| 3| 3| 8| 4| 8| 0| 3|             
                                           | 7| 4| 2| 2| 2| 1| 7| 1| 2| 2| 1| 5| 2| 3| 9| 9| 2| 2| 2| 2| 8| 9| 8| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    4  MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Atrophy, Focal                       |                                                       2                  |             
      Atrophy, Multifocal                  |                                                                          |             
      Hyperplasia, Focal                   |                2           2                                             |             
      Hyperplasia, Multifocal              |                               2                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Multifocal                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                2         |             
      Hyperplasia                          | 3                                      4  3                    3     2   |             
      Inflammation, Subacute               | 3                                      4  3                    2     2   |             
      Perforation                          | 4                                         4                              |             
      Ulcer                                |                                                                      2   |             
      Ulcer, Multiple                      |                                        4                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema, Diffuse                       | 3                                      2                                 |             
      Erosion                              |                                           2                              |             
      Erosion, Multiple                    |                                     2                                    |             
      Ulcer                                | 3                                                                        |             
      Ulcer, Multiple                      |                                        3                                 |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                              +                           |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2                                   1                             1  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                      2   |             
      Focal Cellular Change                |    X              X                                X              X      |             
      Hematopoietic Cell Proliferation     | 2                                                                        |             
      Hemorrhage                           |                                                                X         |             
      Necrosis, Diffuse                    |                                                                      2   |             
      Necrosis, Multifocal                 |                3                                                         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia                          |                                                                      2  2|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |       4  2     4           3        4  4        3     3  3     3     4  3|             
      Pars Distalis, Cyst                  |          X  X        X                    X  X  X                 X     X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 5| 5| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 5| 6| 7| 7|             
                             DAY ON TEST   | 2| 5| 3| 3| 3| 4| 5| 6| 3| 3| 2| 5| 0| 0| 2| 2| 3| 3| 3| 3| 8| 4| 8| 0| 3|             
                                           | 7| 4| 2| 2| 2| 1| 7| 1| 2| 2| 1| 5| 2| 3| 9| 9| 2| 2| 2| 2| 8| 9| 8| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    4  MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |    2        2                             2  2     2              2      |             
      Pars Distalis, Hyperplasia           |          2                    2                                          |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |                1                       2                             2  2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           | 2           2                                                            |             
      C-Cell, Hyperplasia                  |                                           2     2                        |             
      C-Cell, Hyperplasia, Multifocal      |                                                          2           2   |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Acute, Focal,          |                                                                          |             
          Suppurative                      |                                  2                                       |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Focal, Subacute        |                                                                          |             
      Duct, Cyst                           |                      X                                               X   |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                            3                                             |             
      Hyperplasia, Cystic                  |    2                                                                    2|             
      Inflammation, Chronic, Focal         |                                                                          |             
      Prolapse                             |                                                                      3   |             
      Cervix, Cyst                         |                                                                   X      |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                              +                       +   |             
      Inflammation, Acute, Suppurative     |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                   +                                                      |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2  2  2                 2                             3        2   |             
      Myelofibrosis                        |                                                                         2|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pancreatic, Ectasia                  |          3  4        4              3  3                    3        2   |             
      Pancreatic, Hyperplasia              |                      2                                                   |             
      Pancreatic, Inflammation,            |                                                                          |             
          Granulomatous                    |                                                                          |             
      Renal, Ectasia                       |          4                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  M  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 5| 5| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 5| 6| 7| 7|             
                             DAY ON TEST   | 2| 5| 3| 3| 3| 4| 5| 6| 3| 3| 2| 5| 0| 0| 2| 2| 3| 3| 3| 3| 8| 4| 8| 0| 3|             
                                           | 7| 4| 2| 2| 2| 1| 7| 1| 2| 2| 1| 5| 2| 3| 9| 9| 2| 2| 2| 2| 8| 9| 8| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    4  MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Ectasia                              |       2                             3                          2         |             
      Hyperplasia                          |                                                                4         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |             2                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |    1                 2                          2                        |             
      Fibrosis, Focal                      |                                              4                           |             
      Hematopoietic Cell Proliferation     | 3  2     4  2  4        2     4  2                 2     2  4        4   |             
      Necrosis, Focal                      |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Duct, Cyst                           |    X  X  X  X  X  X  X  X  X  X  X  X  X     X  X  X  X  X     X  X  X  X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Hypertrophy, Focal          |       2                 2                    2  2                       3|             
      Femur, Hypertrophy, Focal            |                                                 3        3               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma, Multiple                  |       1                    2           1        1        2           2   |             
      Hemorrhage, Multifocal               |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Histiocyte                       |          2                                                               |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Histiocyte                      |                                        2                 2           2   |             
      Pigmentation, Focal, Cholesterol     |          2                                                               |             
      Pigmentation, Multifocal, Cholesterol|                                                                      2   |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |             2                                                            |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 5| 5| 5| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 3| 5| 6| 7| 7|             
                             DAY ON TEST   | 2| 5| 3| 3| 3| 4| 5| 6| 3| 3| 2| 5| 0| 0| 2| 2| 3| 3| 3| 3| 8| 4| 8| 0| 3|             
                                           | 7| 4| 2| 2| 2| 1| 7| 1| 2| 2| 1| 5| 2| 3| 9| 9| 2| 2| 2| 2| 8| 9| 8| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    4  MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Fat, Mediastinum, Necrosis,          |                                                                          |             
          Multifocal                       |                                     3  2        2     2  2              2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                    2                     |             
      Fungus                               |       3                                   3                              |             
      Inflammation, Acute, Suppurative     |       2                                   3                    3         |             
      Mucosa, Cyst                         |                                                                          |             
      Nasolacrimal Duct, Hyperkeratosis    |                                                                2         |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute, Suppurative              |                      2                                         2         |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Subacute                        |                               2        1     1                    2  2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                    +           +         |             
      Cataract                             |                                                    4                     |             
      Hemorrhage                           |                                                    3           2         |             
      Retina, Degeneration                 |                                                    4                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                +         |             
      Inflammation, Chronic, Suppurative   |                                                                3         |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 2  2  4  1  2  2  2     3  3  2  2  3  4  3  3  3  3  1  2     3  3  4  4|             
      Cortex, Fibrosis, Focal              |             2                                                            |             
      Papilla, Necrosis                    |                                                                          |             
      Pelvis, Inflammation, Acute,         |                                                                          |             
          Suppurative                      |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 8| 2| 3| 3| 3| 6| 9| 3| 3| 3| 0| 9| 1| 3| 3| 2| 6| 3| 3| 3|            |
                                           | 5| 2| 2| 2| 2| 8| 9| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 4| 2| 2| 7| 6| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    4  MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                           2                              |      7  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                                                          |      1     |
      Cyst Multilocular                    |                                  X                    X                  |      2     |
      Developmental Malformation           |                                                             2            |      3  2.0|
      Granuloma, Multiple                  |          2              2                 2        2  2                  |      8  1.8|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                         2                                                |      7  1.9|
      Hemorrhage, Focal                    |                                                                          |      1  2.0|
      Hemorrhage, Multifocal               |                                                                          |      1  2.0|
      Neovascularization                   |                            2                                             |      4  2.0|
      Pigmentation, Hematoidin             |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin, Multifocal|                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1     |
      Biliary Tract, Cyst, Multiple        | 4  4  4  3  3  3  4  4  4  4  3  4  3  4  4  3  4  4  4  3  4  4  3  4  4|     50  3.6|
      Biliary Tract, Fibrosis, Multifocal  | 4  4  4  3  3  3  4  4  4  4  3  4  3  4  4  3  4  4  4  4  4  4  4  4  4|     50  3.7|
      Biliary Tract, Hyperplasia,          |                                                                          |            |
          Multifocal                       | 4  4  4  3  3  3  4  4  3  4  3  4  3  4  4  3  4  4  4  4  4  4  4  4  4|     50  3.7|
      Biliary Tract, Inflammation, Chronic,|                                                                          |            |
           Multifocal                      | 4  4  4  3  3  3  4  4  3  3  3  4  3  4  3  3  4  4  4  4  4  4  4  4  4|     50  3.6|
      Biliary Tract, Metaplasia            | 4  4  4  3  3  3  4  4  3  4  4  4  3  4  4  4  4  4  4  4  4  4  4  4  4|     50  3.8|
      Centrilobular, Necrosis              | 2                             2  2              2           2            |     10  2.1|
      Hepatocyte, Cytomegaly               | 2  2  3  2  2  2  2  2  2  2  2  3  2  3  2  2  2  2  3  2  2  3  2  2  2|     50  2.3|
      Hepatocyte, Degeneration, Multifocal | 3  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  3  2  3  2  2  2  2  2  3|     49  2.1|
      Hepatocyte, Hyperplasia, Multifocal, |                                                                          |            |
           Nodular                         | 2  2  3  2  2  2  2  2  2  2     2  2  3  2     2  2  3  2  2  2  2  2  2|     47  2.2|
      Hepatocyte, Necrosis, Multifocal     | 3  2  2  2  2     2  2  2  2  2  2  2  2  2     3  2  3  2  2  2  2  2  3|     46  2.2|
      Hepatocyte, Vacuolization Cytoplasmic| 2  2  4  4  4  2  2  3  2  3  3  3  3  3  4     2  4  2  2  2  3  3  4  3|     49  2.8|
      Kupffer Cell, Pigmentation,          |                                                                          |            |
          Multifocal                       | 2  2  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|     50  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 8| 2| 3| 3| 3| 6| 9| 3| 3| 3| 0| 9| 1| 3| 3| 2| 6| 3| 3| 3|            |
                                           | 5| 2| 2| 2| 2| 8| 9| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 4| 2| 2| 7| 6| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    4  MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                                                     +  +     +   |   9        |
      Mineralization, Focal                |                                                                2         |      1  2.0|
      Fat, Necrosis, Focal                 |       4                                                        3     3   |      5  3.6|
      Fat, Necrosis, Multifocal            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy, Focal                       |                   2              2  2              1              2      |      6  1.8|
      Atrophy, Multifocal                  |                                                                      2   |      1  2.0|
      Hyperplasia, Focal                   |                                                                          |      2  2.0|
      Hyperplasia, Multifocal              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy, Multifocal                  |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      5  3.0|
      Inflammation, Subacute               |                                                                          |      5  2.8|
      Perforation                          |                                                                          |      2  4.0|
      Ulcer                                |                                                             4            |      2  3.0|
      Ulcer, Multiple                      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema, Diffuse                       |                                                                          |      2  2.5|
      Erosion                              |                                                    2                     |      2  2.0|
      Erosion, Multiple                    |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  3.0|
      Ulcer, Multiple                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2     1                    2        2                    2     1        2|     11  1.6|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1  2.0|
      Focal Cellular Change                |                   X                       X              X               |      7     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 8| 2| 3| 3| 3| 6| 9| 3| 3| 3| 0| 9| 1| 3| 3| 2| 6| 3| 3| 3|            |
                                           | 5| 2| 2| 2| 2| 8| 9| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 4| 2| 2| 7| 6| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    4  MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Necrosis, Diffuse                    |                                                                          |      1  2.0|
      Necrosis, Multifocal                 | 2                                                                        |      2  2.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           | 3  3     2  3  3  3     2  3     2  2     2     2  3     3  2     3     2|     29  2.9|
      Pars Distalis, Cyst                  | X     X           X           X  X        X                 X  X         |     16     |
      Pars Distalis, Hyperplasia, Focal    |       2              2                 2  3           2              2   |     12  2.1|
      Pars Distalis, Hyperplasia           |                                  2                          3            |      4  2.3|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      | 2  2           2  2     2  3        2     2        2     2  2     2     2|     17  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia, Focal           |                                                    2                 2   |      4  2.0|
      C-Cell, Hyperplasia                  |                                                                          |      2  2.0|
      C-Cell, Hyperplasia, Multifocal      |    2        2                                                            |      4  2.0|
      Follicle, Cyst                       |                   X                                                      |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |                                                                      2   |      1  2.0|
      Inflammation, Acute, Focal,          |                                                                          |            |
          Suppurative                      |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                         4|      1  4.0|
      Inflammation, Focal, Subacute        |       2                                                                  |      1  2.0|
      Duct, Cyst                           |       X                                                        X     X   |      5     |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |    X                                                  X                  |      3     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                          3               |      2  3.0|
      Hyperplasia, Cystic                  |                                                                          |      2  2.0|
      Inflammation, Chronic, Focal         |                         2                                                |      1  2.0|
      Prolapse                             |                                                                          |      1  3.0|
      Cervix, Cyst                         |                      X                                                   |      2     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 8| 2| 3| 3| 3| 6| 9| 3| 3| 3| 0| 9| 1| 3| 3| 2| 6| 3| 3| 3|            |
                                           | 5| 2| 2| 2| 2| 8| 9| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 4| 2| 2| 7| 6| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    4  MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   2        |
      Inflammation, Acute, Suppurative     |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                  +                                       |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2  2              2           2                       2                  |     11  2.1|
      Myelofibrosis                        | 2                                                                        |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pancreatic, Ectasia                  |       4  3     3     3  2                 3                    2     3  3|     16  3.0|
      Pancreatic, Hyperplasia              |                                                                         2|      2  2.0|
      Pancreatic, Inflammation,            |                                                                          |            |
          Granulomatous                    |                                                                         2|      1  2.0|
      Renal, Ectasia                       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  +  +  +  +  M  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Ectasia                              |                                                                          |      3  2.3|
      Hyperplasia                          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Ectasia                              |                2  2                                   2                  |      4  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |       2  2  2  1  2  2  2  2           2  2        1  2           1  2   |     17  1.8|
      Fibrosis, Focal                      | 3                                                                        |      2  3.5|
      Hematopoietic Cell Proliferation     |    2  2  2  2  1  2  1  2  2  4                    1  2  2        2  2   |     27  2.4|
      Necrosis, Focal                      | 2                                                           4            |      2  3.0|
      Pigmentation, Hemosiderin            |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Cyst                                 |                                                       X                  |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Duct, Cyst                           | X  X  X  X  X  X  X  X  X  X     X  X  X  X     X  X  X  X  X  X  X  X  X|     45     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cranium, Hypertrophy, Focal          |                                                                         2|      6  2.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 8| 2| 3| 3| 3| 6| 9| 3| 3| 3| 0| 9| 1| 3| 3| 2| 6| 3| 3| 3|            |
                                           | 5| 2| 2| 2| 2| 8| 9| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 4| 2| 2| 7| 6| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    4  MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Femur, Hypertrophy, Focal            |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                    2                     |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma, Multiple                  |    2     2  1     2     2                 2           2        2         |     14  1.7|
      Hemorrhage, Multifocal               |                                  2                                       |      1  2.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Histiocyte                       |    2  2     1                                                            |      4  1.8|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Histiocyte                      |                               2              2  3  2  2                  |      8  2.1|
      Pigmentation, Focal, Cholesterol     |       2  1                                                               |      3  1.7|
      Pigmentation, Multifocal, Cholesterol|                                                    2                     |      2  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Multifocal                      |                                                    2                     |      1  2.0|
      Fat, Mediastinum, Necrosis,          |                                                                          |            |
          Multifocal                       |          2     3                 3                                1  2   |     11  2.2|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                                                                   2      |      2  2.0|
      Fungus                               |                                                                   3      |      3  3.0|
      Inflammation, Acute, Suppurative     |                               3                                   3      |      5  2.8|
      Mucosa, Cyst                         |          X                                                               |      1     |
      Nasolacrimal Duct, Hyperkeratosis    |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute, Suppurative              |                                        1                                 |      3  1.7|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Subacute                        |    2  2     1                                      1     2               |     10  1.6|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cataract                             |                                                                          |      1  4.0|
      Hemorrhage                           |                                                                          |      2  2.5|
      Retina, Degeneration                 |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 5| 7| 7| 7| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 8| 2| 3| 3| 3| 6| 9| 3| 3| 3| 0| 9| 1| 3| 3| 2| 6| 3| 3| 3|            |
                                           | 5| 2| 2| 2| 2| 8| 9| 2| 2| 2| 2| 1| 2| 2| 2| 2| 1| 4| 2| 2| 7| 6| 2| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    4  MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +                                                         |   1        |
      Inflammation, Chronic, Focal         |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
      Inflammation, Chronic, Suppurative   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 | 3  3  3  2  4  2  3  3  2  2  2  2  2  3  4     3  4  3  3  2  2  3  3  3|     47  2.7|
      Cortex, Fibrosis, Focal              |                                                                          |      1  2.0|
      Papilla, Necrosis                    |                                              4                           |      1  4.0|
      Pelvis, Inflammation, Acute,         |                                                                          |            |
          Suppurative                      |                                              2                           |      1  2.0|
      Transitional Epithelium, Hyperplasia |                                              4                           |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Calculus Gross Observation           |                                              X                           |      1     |
      Transitional Epithelium, Hyperplasia |                                              4                           |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5| 7| 7| 7| 7| 3| 6| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 4| 3| 8| 9| 3| 6| 3| 3| 3| 3| 6| 6| 2| 3| 3| 1| 3| 3| 3| 3|             
                                           | 5| 5| 5| 5| 5| 1| 9| 8| 7| 5| 1| 5| 5| 5| 5| 4| 7| 9| 5| 5| 7| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    2  MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                       2                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                           2                    2  2      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             2                                         2           2     2|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X  X  X  X  X  X        X     X  X  X     X  X  X  X  X  X  X  X  X|             
      Cyst Multilocular                    |                                                 X              X  X      |             
      Developmental Malformation           |                                                          2               |             
      Granuloma, Multiple                  |    2  2  1  2        1              2  1  3           2  2  1     2  2  2|             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      | 2        2                                                               |             
      Biliary Tract, Cyst, Multiple        | 3  3  4  3  3  2  3  3  3  3  3  3  3  3  3     3  3  3  3  3  3  3  3  3|             
      Biliary Tract, Fibrosis, Multifocal  | 3  3  3  3  3  3  3  3  3  3  3  3  3  3  3     3  3  3  3  3  3  3  3  3|             
      Biliary Tract, Hyperplasia,          |                                                                          |             
          Multifocal                       | 3  3  3  3  3  3  3  3  3  3  3  3  3  3  3     3  3  3  3  3  3  3  3  3|             
      Biliary Tract, Inflammation, Chronic,|                                                                          |             
           Multifocal                      | 3  3  3  3  3  3  3  3  3  3  3  3  3  3  3     3  3  3  3  3  3  3  3  3|             
      Biliary Tract, Metaplasia            | 3  3  3  3  3  3  3  3  3  3  3  3  3  3  3     3  3  3  3  3  3  3  3  3|             
      Centrilobular, Necrosis              |                                                                          |             
      Hepatocyte, Cytomegaly               |    2  2  3  2  2        2  2  2  2  2  2  2     2  2  2  2  2  2  2  1  1|             
      Hepatocyte, Degeneration, Multifocal |    2  2  2  2  2        2  2     2        2     2        2  2  2     2  2|             
      Hepatocyte, Hyperplasia, Multifocal, |                                                                          |             
           Nodular                         |    2  2  2     2     2  2  2  2  3  2  2  3     2  2  2  2  2  2     2  1|             
      Hepatocyte, Necrosis, Multifocal     |          2              2  2     2        2     2           2  2        2|             
      Hepatocyte, Vacuolization Cytoplasmic|    2  2  2  2  2        2  2     2  2  2  2     2  2  2  2  2  2  2  2  2|             
      Kupffer Cell, Pigmentation,          |                                                                          |             
          Multifocal                       | 1  1  1  1  1  2  2  2  2  2  2  2  2  2  2     2  2  2  1  1  1  1  2  1|             
                                            __________________________________________________________________________|             
   Mesentery                               |       +  +        +  +                             +           +         |             
      Fat, Necrosis, Focal                 |       4  3        3  3                             4           3         |             
      Fat, Necrosis, Multifocal            |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |          1                    1                                          |             
      Atrophy, Multifocal                  |                   2        2     2                                       |             
      Hyperplasia, Focal                   |                                                       2                  |             
      Hyperplasia, Multifocal              |                                                                         2|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5| 7| 7| 7| 7| 3| 6| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 4| 3| 8| 9| 3| 6| 3| 3| 3| 3| 6| 6| 2| 3| 3| 1| 3| 3| 3| 3|             
                                           | 5| 5| 5| 5| 5| 1| 9| 8| 7| 5| 1| 5| 5| 5| 5| 4| 7| 9| 5| 5| 7| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    2  MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Hyperplasia                          |                                                             2            |             
      Inflammation, Subacute               |                                                                          |             
      Artery, Inflammation, Subacute       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2        2  2  2           2  1           2        1  2  2  1  2     1  1|             
      Granuloma                            |                                                                          |             
      Pericardium, Fibrosis                |                                                                          |             
      Pericardium, Necrosis, Focal         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Focal Cellular Change                |          X           X                    X                             X|             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Multifocal              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |       3  4  3     2  3              3  3  3     2           4     2  3   |             
      Pars Distalis, Cyst                  | X     X              X           X                                X      |             
      Pars Distalis, Hyperplasia, Focal    |                   2     2  2                       2  2  2              2|             
      Pars Distalis, Hyperplasia           |                                                                          |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |       2  1                          1     2     2           2            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |                            2     2  2                                    |             
      C-Cell, Hyperplasia                  |                                                                          |             
      C-Cell, Hyperplasia, Multifocal      |       2                 2                                                |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5| 7| 7| 7| 7| 3| 6| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 4| 3| 8| 9| 3| 6| 3| 3| 3| 3| 6| 6| 2| 3| 3| 1| 3| 3| 3| 3|             
                                           | 5| 5| 5| 5| 5| 1| 9| 8| 7| 5| 1| 5| 5| 5| 5| 4| 7| 9| 5| 5| 7| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    2  MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Inflammation, Acute, Focal,          |                                                                          |             
          Suppurative                      |                                                                          |             
      Duct, Cyst                           |       X                          X  X                                    |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                         X|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                                                                          |             
      Hyperplasia, Cystic                  |                                                                2        2|             
      Prolapse                             | X                                                                        |             
      Cervix, Cyst                         |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                 2  2                                                  2|             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Myelofibrosis                        |                                                    2                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pancreatic, Ectasia                  |                               3                                         4|             
      Pancreatic, Hyperplasia              |                               2                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                  2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                            2                                             |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                  2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                            2                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |       2        2              2                    2              2      |             
      Hematopoietic Cell Proliferation     | 3  2           2     2                                   2     2     2  2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      X                    X                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Cyst                           | X  X  X  X  X     X  X  X  X     X  X  X  X        X  X  X  X  X  X  X  X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5| 7| 7| 7| 7| 3| 6| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 4| 3| 8| 9| 3| 6| 3| 3| 3| 3| 6| 6| 2| 3| 3| 1| 3| 3| 3| 3|             
                                           | 5| 5| 5| 5| 5| 1| 9| 8| 7| 5| 1| 5| 5| 5| 5| 4| 7| 9| 5| 5| 7| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    2  MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Cranium, Hypertrophy, Focal          |                2                                               2         |             
      Femur, Hypertrophy, Focal            |    2           2                       2                       3         |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Hemorrhage, Focal                    |                                                                          |             
      Hemorrhage, Multifocal               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Granuloma, Multiple                  | 2              2              2                 2              2         |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Histiocyte                       | 2                                                                        |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Histiocyte                      |                                                                2         |             
      Pigmentation, Focal, Cholesterol     | 2                                                                        |             
      Pigmentation, Multifocal, Cholesterol|                                                                2         |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                  3                                       |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |                                                                          |             
      Fat, Mediastinum, Necrosis,          |                                                                          |             
          Multifocal                       |       2        2     2        2                    2           2         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                        2                                 |             
      Fungus                               |                                                                         2|             
      Inflammation, Acute, Suppurative     |                                        2                                2|             
      Nasolacrimal Duct, Foreign Body      |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Subacute                        |    2                                               2                     |             
      Nasopharyngeal Duct, Foreign Body    |                                                                          |             
      Nasopharyngeal Duct, Inflammation,   |                                                                          |             
           Subacute                        |       2                                                                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +                                                   |             
      Cataract                             |                      2                                                   |             
      Hemorrhage                           |                                                                          |             
      Retina, Degeneration                 |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5| 7| 7| 7| 7| 3| 6| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 3| 4| 3| 8| 9| 3| 6| 3| 3| 3| 3| 6| 6| 2| 3| 3| 1| 3| 3| 3| 3|             
                                           | 5| 5| 5| 5| 5| 1| 9| 8| 7| 5| 1| 5| 5| 5| 5| 4| 7| 9| 5| 5| 7| 5| 5| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    2  MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 1  2  3  2  2     2  1  2  2  1  3  2  1  3     1  2  2  2  2  2  2  2  2|             
      Cortex, Fibrosis, Focal              |                   2                                                      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 6| 7| 7| 4| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 7| 7| 5| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 4| 6| 0| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 8| 5| 9| 5| 5| 6| 2| 9| 5| 5| 3| 5| 5| 5| 5| 2| 5| 3| 5| 5| 5| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      A     |
    2  MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                   2      |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |             2              2                          2                  |      6  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                      2  2  2           2              2     2  2  2      |     12  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |       X  X  X        X  X     X  X  X  X  X        X  X  X  X  X     X  X|     38     |
      Cyst Multilocular                    |    X     X                                                     X         |      6     |
      Developmental Malformation           |                                                                          |      1  2.0|
      Granuloma, Multiple                  |    2           2        2     1                                         2|     19  1.8|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |          1                          2  2           2        2            |      7  1.9|
      Biliary Tract, Cyst, Multiple        | 2  3  3  3  3  2  3  3  3  3  3  3  3  3  2  2  2  3  3  3  2  3  3  3  3|     49  2.9|
      Biliary Tract, Fibrosis, Multifocal  | 3  3  3  3  3  2  3  3  3  3  4  3  3  3  2  2  3  3  3  3  2  3  3  3  4|     49  3.0|
      Biliary Tract, Hyperplasia,          |                                                                          |            |
          Multifocal                       | 3  3  3  2  3  2  3  3  3  3  3  3  3  3  2  3  3  3  3  3  2  3  3  3  3|     49  2.9|
      Biliary Tract, Inflammation, Chronic,|                                                                          |            |
           Multifocal                      | 3  3  3  3  3  2  3  3  3  3  3  3  3  3  2  3  3  3  3  3  2  3  3  3  3|     49  2.9|
      Biliary Tract, Metaplasia            | 3  3  3  3  3  3  3  3  3  3  3  3  3  3  2  3  3  3  3  3  2  3  3  3  3|     49  3.0|
      Centrilobular, Necrosis              |                                              2  2                        |      2  2.0|
      Hepatocyte, Cytomegaly               |    2  1  1  1  2  2  2  2  2  2  2  2  1  1  3  3  2  2  2  2     2  2  2|     44  1.9|
      Hepatocyte, Degeneration, Multifocal | 2  2  1  1  1  2  2  1  2     2  2  2  2  2     2           2  2  2  2  2|     35  1.9|
      Hepatocyte, Hyperplasia, Multifocal, |                                                                          |            |
           Nodular                         |          2  2     2  1  2     2     2  2        2           2        2  2|     32  2.0|
      Hepatocyte, Necrosis, Multifocal     | 2              2     1  1     2                 2           2     2  2   |     18  1.9|
      Hepatocyte, Vacuolization Cytoplasmic|    2  2  3  2  2  2  1  3     2  2  3  2  2  2  3  2  2  2  2  2  2  3  2|     43  2.1|
      Kupffer Cell, Pigmentation,          |                                                                          |            |
          Multifocal                       | 2  2  1  1  1  2  1  1  1  1  2  2  2  1  2  2  1  1  2  1  2  1  2  2  2|     49  1.6|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                 +        +     +                    +        +      |  12        |
      Fat, Necrosis, Focal                 |    3                 2        2     4                             3      |     11  3.1|
      Fat, Necrosis, Multifocal            |                                                          4               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 6| 7| 7| 4| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 7| 7| 5| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 4| 6| 0| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 8| 5| 9| 5| 5| 6| 2| 9| 5| 5| 3| 5| 5| 5| 5| 2| 5| 3| 5| 5| 5| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      A     |
    2  MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Atrophy, Focal                       |                                              2        1  2  1            |      6  1.3|
      Atrophy, Multifocal                  |                         1           1                                    |      5  1.6|
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Hyperplasia, Multifocal              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                 2                        |      1  2.0|
      Hyperplasia                          |                                                 2                        |      2  2.0|
      Inflammation, Subacute               |                                                 2                        |      1  2.0|
      Artery, Inflammation, Subacute       |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                               2                                          |      1  2.0|
      Inflammation, Subacute               |                               3                                          |      1  3.0|
      Ulcer                                |                               2                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |       2  2  2           2     1        1  1           2  2        1     2|     25  1.6|
      Granuloma                            |                                     4                                    |      1  4.0|
      Pericardium, Fibrosis                |                                     3                                    |      1  3.0|
      Pericardium, Necrosis, Focal         |                                     3                                    |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                     X                                    |      1     |
      Focal Cellular Change                |          X        X     X                       X                    X   |      9     |
      Thrombosis                           |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                  X                                       |      1     |
      Hyperplasia, Multifocal              |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |    1  4  3  2  4  1  3  3  3  4        4  3     3  2        3  4  3  3   |     30  2.9|
      Pars Distalis, Cyst                  |                         X                 X        X     X               |      9     |
      Pars Distalis, Hyperplasia, Focal    |                                  2  1                 2  2               |     11  1.9|
      Pars Distalis, Hyperplasia           |    2              2                                                      |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 6| 7| 7| 4| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 7| 7| 5| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 4| 6| 0| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 8| 5| 9| 5| 5| 6| 2| 9| 5| 5| 3| 5| 5| 5| 5| 2| 5| 3| 5| 5| 5| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      A     |
    2  MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |       1  1           1  2  1  2        2  2        2     1  2  1     2   |     19  1.6|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia, Focal           | 2                       2  2                                             |      6  2.0|
      C-Cell, Hyperplasia                  |                                                 2                        |      1  2.0|
      C-Cell, Hyperplasia, Multifocal      |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Acute, Focal,          |                                                                          |            |
          Suppurative                      |                                                             2            |      1  2.0|
      Duct, Cyst                           |                                                             X        X   |      5     |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |       X                                                                 X|      3     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hydrometra                           |                                  2  2                                   2|      3  2.0|
      Hyperplasia, Cystic                  |                                  2                                      2|      4  2.0|
      Prolapse                             |                                                                          |      1     |
      Cervix, Cyst                         |                                                                         X|      1     |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          | 2                                   2              2                    1|      8  1.9|
      Infiltration Cellular, Histiocyte    |                                                             4            |      1  4.0|
      Myelofibrosis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pancreatic, Ectasia                  |       3           2        2                                4            |      6  3.0|
      Pancreatic, Hyperplasia              |       2                                                                  |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  +  M  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  43        |
      Ectasia                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Ectasia                              |                                  2     2                    2            |      4  2.0|
      Hyperplasia                          |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  48        |
      Ectasia                              |    2                    1                                                |      3  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 6| 7| 7| 4| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 7| 7| 5| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 4| 6| 0| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 8| 5| 9| 5| 5| 6| 2| 9| 5| 5| 3| 5| 5| 5| 5| 2| 5| 3| 5| 5| 5| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      A     |
    2  MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Ectasia                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                         2                                                |      6  2.0|
      Hematopoietic Cell Proliferation     | 2                                2  2              4     1  4            |     14  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Cyst                                 |                         X                                                |      3     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Duct, Cyst                           |    X  X  X  X  X  X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X  X|     44     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cranium, Hypertrophy, Focal          |                   2                       2                              |      4  2.0|
      Femur, Hypertrophy, Focal            |                                           3                              |      5  2.4|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |       3        2              4                                          |      3  3.0|
      Hemorrhage, Focal                    |                                                             2            |      1  2.0|
      Hemorrhage, Multifocal               |                                              4                           |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |          4                                                               |      1  4.0|
      Granuloma, Multiple                  |       1     1        1     2        1  2              2  2  2            |     14  1.7|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Histiocyte                       |       2           1                       2              1               |      5  1.6|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Histiocyte                      |                            2           2                          2      |      4  2.0|
      Pigmentation, Focal, Cholesterol     |       1                    1                                             |      3  1.3|
      Pigmentation, Multifocal, Cholesterol|                                        2                                 |      2  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                           2                              |      2  2.5|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Multifocal                      |                                                                   2      |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 6| 7| 7| 4| 6| 6| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 7| 7| 5| 3| 3| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 4| 6| 0| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 8| 5| 9| 5| 5| 6| 2| 9| 5| 5| 3| 5| 5| 5| 5| 2| 5| 3| 5| 5| 5| 5| 5| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|      A     |
    2  MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Fat, Mediastinum, Necrosis,          |                                                                          |            |
          Multifocal                       |                      2        1     2           2                        |     10  1.9|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |             2                                                            |      2  2.0|
      Fungus                               |                                                                          |      1  2.0|
      Inflammation, Acute, Suppurative     |             1                                2                           |      4  1.8|
      Nasolacrimal Duct, Foreign Body      |                                                                2         |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Subacute                        |                                                                2         |      3  2.0|
      Nasopharyngeal Duct, Foreign Body    |                         2                                                |      1  2.0|
      Nasopharyngeal Duct, Inflammation,   |                                                                          |            |
           Subacute                        |                         2                                                |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     | +                          +                                             |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                         +                                            +   |   3        |
      Cataract                             |                         3                                            4   |      3  3.0|
      Hemorrhage                           |                         3                                                |      1  3.0|
      Retina, Degeneration                 |                                                                      4   |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 |    1  2  1  2  3  2  1  3  3  2  1  2  2  3  1  2  1  3  2  2  3  2  2  2|     47  2.0|
      Cortex, Fibrosis, Focal              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 3| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 4| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 1| 1| 2| 4| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 8| 0| 3| 3| 3| 1| 1| 1| 3| 3|             
                                           | 5| 9| 9| 5| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 8| 7| 1| 1| 1| 1| 3| 6| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
      Ulcer, Multiple                      |          3                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                     2           2                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                         2                                2           2   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |       X     X        X  X  X  X  X  X  X           X  X        X  X  X  X|             
      Clear Cell Focus                     |                         X        X                       X               |             
      Degeneration, Cystic, Focal          |                                           2                              |             
      Degeneration, Cystic                 |                   2                                                      |             
      Degeneration, Cystic, Multifocal     |                                                                          |             
      Developmental Malformation           |                                                                          |             
      Eosinophilic Focus                   |             X     X        X              X        X           X         |             
      Granuloma, Multiple                  |                                        2                                 |             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                                                          |             
      Necrosis, Focal                      |                2                                                         |             
      Biliary Tract, Ectasia, Focal        |                                                                          |             
      Biliary Tract, Proliferation         |          2  2  2  2  2  2  2  2  1        2        1  2  2     1  2  2  1|             
      Centrilobular, Necrosis              |          2                                                  2        1   |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                2         |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                  +            |             
      Fat, Necrosis, Focal                 |                                                             4            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |             1  2     2                                1  1        2      |             
      Atrophy, Multifocal                  |                         2        4                                   2   |             
      Hyperplasia, Focal                   |                      2                                                  3|             
      Hyperplasia                          |                   2                                                      |             
      Hyperplasia, Multifocal              |                         2  3  3     2              3     2  2  2         |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Inflammation, Focal, Subacute        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               4                                          |             
      Inflammation, Subacute               |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 3| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 4| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 1| 1| 2| 4| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 8| 0| 3| 3| 3| 1| 1| 1| 3| 3|             
                                           | 5| 9| 9| 5| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 8| 7| 1| 1| 1| 1| 3| 6| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion, Multiple                    |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Foreign Body                         |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                  +                                       |             
      Dysplasia                            |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |             2  2  3  2  2  1  1  2     2              2  1  1  2        2|             
      Inflammation, Acute, Multifocal,     |                                                                          |             
           Suppurative                     |          3                                                               |             
      Thrombosis                           |          X                                                               |             
      Valve, Embolus Bacterial             |          4                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |                            X                                             |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                2           2     2     3           3              2      |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                2           2        2                 2     3            |             
      Pars Distalis, Hyperplasia           |                                                                          |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |                2     2           2                 2              1      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia, Focal           |                               2                                          |             
      C-Cell, Hyperplasia                  |                                                                          |             
      C-Cell, Hyperplasia, Multifocal      |                                  2                                       |             
      Follicle, Cyst                       |             X                                                           X|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 3| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 4| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 1| 1| 2| 4| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 8| 0| 3| 3| 3| 1| 1| 1| 3| 3|             
                                           | 5| 9| 9| 5| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 8| 7| 1| 1| 1| 1| 3| 6| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Granuloma                            |                                                                          |             
      Hyperplasia                          |                                                                      2   |             
      Inflammation, Acute, Focal,          |                                                                          |             
          Suppurative                      |                   4                 2                                    |             
      Inflammation, Chronic                |                                                                      1   |             
      Inflammation, Focal, Subacute        |                                                                          |             
      Duct, Cyst                           |                   X                                                      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |             1                          3              3  2  3     3      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                     3              3                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  M  M  M  M  M  +|             
      Ectasia                              |                2                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +|             
      Ectasia                              |                   2  2  2  2                                      2      |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                   2                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  M  +  +  +  +  +  +|             
      Ectasia                              |                2                       2                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |       2                 2                          2                     |             
      Fibrosis, Focal                      |          2                    3        3                                 |             
      Hematopoietic Cell Proliferation     |             1           1                 1        1        2            |             
      Necrosis, Focal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Cyst                           |             X  X        X  X     X     X           X  X  X  X     X     X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Multifocal, Subacute   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 3| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 4| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 1| 1| 2| 4| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 8| 0| 3| 3| 3| 1| 1| 1| 3| 3|             
                                           | 5| 9| 9| 5| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 8| 7| 1| 1| 1| 1| 3| 6| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             X                                                            |             
      Hemorrhage, Multifocal               |                                                                          |             
      Inflammation, Acute, Multifocal,     |                                                                          |             
           Suppurative                     |          2                                                               |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Degeneration                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 3  2  2                                         3                 2      |             
      Foreign Body                         | 3  3                                         4  3                        |             
      Granuloma, Multiple                  |          2  2  2  2                                      3               |             
      Hyperplasia                          |                            2                                             |             
      Infiltration Cellular, Histiocyte    |                                                                      1   |             
      Inflammation, Subacute               |                                              2                           |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                  3                                   2   |             
      Fat, Mediastinum, Necrosis,          |                                                                          |             
          Multifocal                       |                                                                          |             
      Mediastinum, Inflammation, Chronic,  |                                                                          |             
           Multifocal                      |                                                                          |             
      Pleura, Fibrosis, Focal              |          2                                                               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                      2  2                 2        3                 2   |             
      Fungus                               |                                                    2                     |             
      Inflammation, Acute, Suppurative     |                      2  2                          2                 1   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute, Suppurative              |                            2                                         2   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Subacute                        |                2                                                         |             
      Nasopharyngeal Duct, Cyst            |                                                                          |             
      Nasopharyngeal Duct, Foreign Body    |                                                                          |             
      Nasopharyngeal Duct, Inflammation,   |                                                                          |             
           Subacute                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                         +|             
      Cataract                             |                                                                         3|             
      Retina, Degeneration                 |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 3| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 4| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 1| 1| 2| 4| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 8| 0| 3| 3| 3| 1| 1| 1| 3| 3|             
                                           | 5| 9| 9| 5| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 8| 7| 1| 1| 1| 1| 3| 6| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 |       1  1  1  1  2  2  2  2  1  1  1  3  1        1  2  2  1  1  2  1  4|             
      Cortex, Cyst                         |                                                       X                  |             
      Cortex, Embolus Bacterial            |          2                                                               |             
      Cortex, Fibrosis, Focal              |                                  2                                       |             
      Cortex, Inflammation, Acute,         |                                                                          |             
          Multifocal, Suppurative          |          2                                                               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 0| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 4| 3| 3| 3| 6| 8| 3| 3| 3| 6| 8| 3| 3| 3|            |
                                           | 4| 1| 1| 1| 1| 9| 1| 1| 1| 1| 3| 9| 1| 1| 1| 0| 0| 1| 1| 1| 6| 9| 1| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |          2  2                                                            |      2  2.0|
      Ulcer, Multiple                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite Metazoan                    |                   2                                      2               |      4  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                     2  2                                 |      5  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |    X  X  X  X        X  X  X        X  X  X     X  X     X  X  X     X  X|     32     |
      Clear Cell Focus                     |       X           X     X                                         X  X   |      8     |
      Degeneration, Cystic, Focal          |                                        2                                2|      3  2.0|
      Degeneration, Cystic                 |                                     1                                    |      2  1.5|
      Degeneration, Cystic, Multifocal     |                                              2                           |      1  2.0|
      Developmental Malformation           |                   X     X     X                                          |      3     |
      Eosinophilic Focus                   |    X                       X     X  X  X     X                    X  X   |     14     |
      Granuloma, Multiple                  |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                                                             2            |      1  2.0|
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Biliary Tract, Ectasia, Focal        |       2                                                                  |      1  2.0|
      Biliary Tract, Proliferation         |    1  1  1  1  2  2  1  1  2     1  1  1  1  3  2  1  3  1     2  1  2  2|     39  1.6|
      Centrilobular, Necrosis              |                2                             2                           |      5  1.8|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                               +     +         |   5        |
      Fat, Necrosis, Focal                 |                                                          4     4         |      3  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy, Focal                       |          1                 2                             1               |      9  1.4|
      Atrophy, Multifocal                  |                      3                       2                          2|      6  2.5|
      Hyperplasia, Focal                   |       2  2  2           2                                2     2         |      8  2.1|
      Hyperplasia                          |                                                       2                  |      2  2.0|
      Hyperplasia, Multifocal              |    2                       3              3     3                       3|     13  2.5|
      Inflammation, Chronic, Focal         |       2                                                                  |      1  2.0|
      Inflammation, Focal, Subacute        |                      2                                                   |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 0| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 4| 3| 3| 3| 6| 8| 3| 3| 3| 6| 8| 3| 3| 3|            |
                                           | 4| 1| 1| 1| 1| 9| 1| 1| 1| 1| 3| 9| 1| 1| 1| 0| 0| 1| 1| 1| 6| 9| 1| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  4.0|
      Inflammation, Subacute               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion, Multiple                    |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                             +            |   1        |
      Foreign Body                         |                                                             2            |      1  2.0|
      Inflammation, Granulomatous          |                                                             3            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Dysplasia                            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |    1  2  1     2  2  2  1           2  1     2     2     2  2  2  1      |     29  1.7|
      Inflammation, Acute, Multifocal,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  3.0|
      Thrombosis                           |                                                                          |      1     |
      Valve, Embolus Bacterial             |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Focal Cellular Change                |                                                       X                  |      2     |
      Vacuolization Cytoplasmic, Diffuse   |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal                   |       2  2                                                               |      2  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           |                                                    3  3  2     3         |     10  2.5|
      Pars Distalis, Cyst                  | X                                            X                           |      2     |
      Pars Distalis, Hyperplasia, Focal    | 2                          2     2  2                                   2|     10  2.1|
      Pars Distalis, Hyperplasia           |                                                          2               |      1  2.0|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |                   2                                            2         |      7  1.9|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 0| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 4| 3| 3| 3| 6| 8| 3| 3| 3| 6| 8| 3| 3| 3|            |
                                           | 4| 1| 1| 1| 1| 9| 1| 1| 1| 1| 3| 9| 1| 1| 1| 0| 0| 1| 1| 1| 6| 9| 1| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Ultimobranchial Cyst                 |          X                                                               |      1     |
      C-Cell, Hyperplasia, Focal           |                                                                2        2|      3  2.0|
      C-Cell, Hyperplasia                  |             2                                         2                  |      2  2.0|
      C-Cell, Hyperplasia, Multifocal      |                                                                          |      1  2.0|
      Follicle, Cyst                       |                                                                          |      2     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Foreign Body                         |                      2                                                   |      1  2.0|
      Granuloma                            |                      2                                                   |      1  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Acute, Focal,          |                                                                          |            |
          Suppurative                      |    2                                                                     |      3  2.7|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Focal, Subacute        |                                              2                           |      1  2.0|
      Duct, Cyst                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Subacute               |                                                       2                 2|      8  2.4|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                              +                           |   1        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Necrosis                             |                                                 4                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  M  M  M  +  +  +  +  +  M  +  +  M  +  +  +  M  +  +  M  +  +  M|  34        |
      Ectasia                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Ectasia                              |             3        2              3              2        2            |     10  2.2|
      Hyperplasia                          |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  48        |
      Congestion                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  46        |
      Ectasia                              |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 0| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 4| 3| 3| 3| 6| 8| 3| 3| 3| 6| 8| 3| 3| 3|            |
                                           | 4| 1| 1| 1| 1| 9| 1| 1| 1| 1| 3| 9| 1| 1| 1| 0| 0| 1| 1| 1| 6| 9| 1| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |    2                                                                    2|      5  2.0|
      Fibrosis, Focal                      |                3                                                         |      4  2.8|
      Hematopoietic Cell Proliferation     | 3     2           1                                                     2|      9  1.6|
      Necrosis, Focal                      |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Duct, Cyst                           |                            X     X     X     X  X     X  X     X         |     20     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Multifocal, Subacute   |                                                 3                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1     |
      Hemorrhage, Multifocal               |                                              4                           |      1  4.0|
      Inflammation, Acute, Multifocal,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                +         |   1        |
      Degeneration                         |                                                                3         |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                               3                                          |      6  2.5|
      Foreign Body                         |                               3                                          |      5  3.2|
      Granuloma, Multiple                  | 2                                                  2              1  2   |      9  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  1.0|
      Inflammation, Subacute               |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |       2                    3                                             |      2  2.5|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  2.5|
      Fat, Mediastinum, Necrosis,          |                                                                          |            |
          Multifocal                       |       2                                                                  |      1  2.0|
      Mediastinum, Inflammation, Chronic,  |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 0| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7|            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 5| 3| 3| 3| 3| 5| 4| 3| 3| 3| 6| 8| 3| 3| 3| 6| 8| 3| 3| 3|            |
                                           | 4| 1| 1| 1| 1| 9| 1| 1| 1| 1| 3| 9| 1| 1| 1| 0| 0| 1| 1| 1| 6| 9| 1| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Multifocal                      |                                                       2                  |      1  2.0|
      Pleura, Fibrosis, Focal              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |    2  2  2           2  2  2     2        2                 2  2  2      |     16  2.1|
      Fungus                               |    3  2              3                                      2            |      5  2.4|
      Inflammation, Acute, Suppurative     |    3  2  2           3  2                                   3     2      |     11  2.2|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute, Suppurative              |                            1     4                                       |      4  2.3|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Subacute                        |                                                                          |      1  2.0|
      Nasopharyngeal Duct, Cyst            |                                  X                                       |      1     |
      Nasopharyngeal Duct, Foreign Body    |                                  4                                       |      1  4.0|
      Nasopharyngeal Duct, Inflammation,   |                                                                          |            |
           Subacute                        |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cataract                             |                                                                          |      1  3.0|
      Retina, Degeneration                 |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 | 1  2  1  2  2  2  2  2  2  2     2  4  3  2  2  2  1  1  2  2  1  1  1  3|     45  1.7|
      Cortex, Cyst                         |                                                                          |      1     |
      Cortex, Embolus Bacterial            |                                                                          |      1  2.0|
      Cortex, Fibrosis, Focal              |                                                                          |      1  2.0|
      Cortex, Inflammation, Acute,         |                                                                          |            |
          Multifocal, Suppurative          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 4| 4| 6| 6| 7| 6| 5| 6| 6| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 3| 3| 3| 4| 8| 8| 3| 3| 2| 4| 5| 9| 3| 6| 8| 6| 9| 3| 8| 9| 9| 3| 3|             
                                           | 9| 9| 0| 0| 0| 5| 6| 8| 0| 0| 1| 8| 6| 5| 0| 5| 3| 7| 5| 0| 8| 5| 6| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    8  MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                         2                 2        2                    2|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                2         |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                      X   |             
      Cyst Multilocular                    | X  X  X  X  X           X  X           X     X     X  X  X  X  X  X      |             
      Developmental Malformation           |                                                                          |             
      Granuloma, Multiple                  |    2                                                                     |             
      Hemorrhage, Multifocal               |                            2                                             |             
      Neovascularization                   | 1        2  2                                2     2           2  3  2  2|             
      Thrombosis                           |                                                             X  X         |             
      Biliary Tract, Cyst, Multiple        | 4  4  4  4  4  4  4  4  4  4  3  3  4  4  4  4  4  4  4  4  4  4  4  4  4|             
      Biliary Tract, Fibrosis, Multifocal  | 4  4  4  4  4  4  4  4  4  4  3  3  4  4  4  4  4  4  4  4  4  4  4  4  4|             
      Biliary Tract, Hyperplasia,          |                                                                          |             
          Multifocal                       | 4  4  4  4  4  4  4  4  4  4  3  3  4  4  4  4  4  4  4  4  4  4  4  4  4|             
      Biliary Tract, Inflammation, Chronic,|                                                                          |             
           Multifocal                      | 4  4  4  4  4  4  4  4  4  4  3  3  4  4  4  4  4  4  4  4  4  4  4  4  4|             
      Biliary Tract, Metaplasia            | 4  3  4  4  4  4  4  4  4  4  3  3  4  4  4  4  3  4  4  4  4  4  4  4  4|             
      Centrilobular, Necrosis              |                2  2  2  2     2                                          |             
      Hepatocyte, Cytomegaly               | 4  4  4  4  4  4  4  4  4  4  3  3  4  4  4  4  4  4  4  4  4  4  3  4  4|             
      Hepatocyte, Degeneration, Multifocal | 2  3  3  3  4  4  4  3  3  4  3  4  3  3  3  3  3  3  3  3  3  4  3  3  3|             
      Hepatocyte, Hyperplasia, Multifocal, |                                                                          |             
           Nodular                         | 3  4  4  4  4  4  4  4  4  4  3  3  4  4  4  4  4  4  4  4  4  4  4  4  4|             
      Hepatocyte, Necrosis, Multifocal     | 2  2  2  2  2  4  3  3  3  3  3  4  3  2  2  4  2  2  2  2  2  2  2  2  2|             
      Hepatocyte, Vacuolization Cytoplasmic| 3  3  3  3  3  4  4  3  3  4  2  4  3  4  3  4  3  4  4  3  3  4  3  3  3|             
      Kupffer Cell, Pigmentation,          |                                                                          |             
          Multifocal                       | 2  2  2  2  2  2  2  2  2  2  3  2  2  2  2  2  2  2  2  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +  +                                +                          +      |             
      Pigmentation, Hemosiderin, Multifocal| 2  2                                                                     |             
      Fat, Hemorrhage                      |                                                                          |             
      Fat, Necrosis, Focal                 |    4  4                                4                          4      |             
      Fat, Necrosis, Multifocal            |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                1  1  2                             1                 2   |             
      Atrophy, Multifocal                  | 1                                         2           1                  |             
      Hyperplasia, Focal                   | 2  2     2                    2        3     2                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 4| 4| 6| 6| 7| 6| 5| 6| 6| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 3| 3| 3| 4| 8| 8| 3| 3| 2| 4| 5| 9| 3| 6| 8| 6| 9| 3| 8| 9| 9| 3| 3|             
                                           | 9| 9| 0| 0| 0| 5| 6| 8| 0| 0| 1| 8| 6| 5| 0| 5| 3| 7| 5| 0| 8| 5| 6| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    8  MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |             2                                                            |             
      Hyperplasia, Multifocal              |                            2                    2  2        2     2      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Hyperplasia, Squamous                |                   3                                                      |             
      Inflammation, Subacute               |                                                                          |             
      Ulcer                                |                                                                          |             
      Ulcer, Multiple                      |                   2  2              4                                    |             
      Serosa, Fibrosis, Focal              |                                                                2         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Erosion                              |                                                             2            |             
      Erosion, Multiple                    |                                                                          |             
      Mineralization, Multifocal           |                                                                          |             
      Ulcer                                |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2  2  2  1  2  2     2  1     2  2  3  2  3  2  2  1  1  2     3  3  2|             
      Mineralization, Multifocal           |                                     2                                    |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                    2                     |             
      Focal Cellular Change                |                                                                   X      |             
      Capsule, Fibrosis, Focal             |                                                                2         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia, Multifocal              |       2                                                                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia                          |                                     2        2                    2     2|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |       3        3                    3                                   4|             
      Pars Distalis, Cyst                  |                   X                                      X               |             
      Pars Distalis, Hyperplasia, Focal    |                      2              3     2                       2      |             
      Pars Distalis, Hyperplasia           |                                                                          |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |       2                                                                 3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 4| 4| 6| 6| 7| 6| 5| 6| 6| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 3| 3| 3| 4| 8| 8| 3| 3| 2| 4| 5| 9| 3| 6| 8| 6| 9| 3| 8| 9| 9| 3| 3|             
                                           | 9| 9| 0| 0| 0| 5| 6| 8| 0| 0| 1| 8| 6| 5| 0| 5| 3| 7| 5| 0| 8| 5| 6| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    8  MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Intermedia, Cyst                | X                                                                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |                                                                          |             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Cyst                       |                                                       X  X           X   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Inflammation, Acute, Focal,          |                                                                          |             
          Suppurative                      |             2                                            4               |             
      Duct, Cyst                           |                X              X                          X               |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Suppurative     |                                                                          |             
      Inflammation, Subacute               |             2                       4     2        2  1                  |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
      Inflammation, Acute, Suppurative     |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Polychromasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  2  2  2              2  1        1  2  2  3              2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pancreatic, Ectasia                  |          3     3  3     2     3        3        3  4  2  4  4            |             
      Pancreatic, Hyperplasia              |          3                             2     3              4            |             
      Renal, Ectasia                       | 4     3                                                                  |             
      Renal, Hyperplasia                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  M  M  +  M  M  M  M  M  +  +  +  +  M  M  M  M  +  M  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia                          |                                           2                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Congestion                           |                                                                          |             
      Ectasia                              | 4  2                                      2                          2  2|             
      Hyperplasia                          |                                           2           2                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Ectasia                              | 1  2                       2           3     2           3     2  2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 4| 4| 6| 6| 7| 6| 5| 6| 6| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 3| 3| 3| 4| 8| 8| 3| 3| 2| 4| 5| 9| 3| 6| 8| 6| 9| 3| 8| 9| 9| 3| 3|             
                                           | 9| 9| 0| 0| 0| 5| 6| 8| 0| 0| 1| 8| 6| 5| 0| 5| 3| 7| 5| 0| 8| 5| 6| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    8  MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |       2  2                                2           2           2      |             
      Pigmentation, Hemosiderin            |       2                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |          2        2                                2              2      |             
      Hyperplasia                          |                                                                   2      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 2  2  1  2  2                       2     2  2     2  2     2  1  3  2  2|             
      Degeneration, Fatty, Multifocal      |                                           2                              |             
      Fibrosis, Focal                      |       4                             2     3                              |             
      Hematopoietic Cell Proliferation     |    1  2  2                 2  2  2  1  3  2  4     2  2     2  1     3  3|             
      Necrosis, Focal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Cyst                           | X  X  X     X  X  X     X                 X     X     X                 X|             
      Duct, Hemorrhage, Focal              |    3                                                                     |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Edema, Focal    |             4                                      4                     |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Focal, Subacute                 |             2                                      3                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                     1                                    |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                  3                                       |             
      Foreign Body                         |                                  2                                       |             
      Fungus                               |                                                                          |             
      Granuloma, Multiple                  |    1        1              1              1                 1           2|             
      Hemorrhage, Focal                    |                                                 2                 2      |             
      Hemorrhage, Multifocal               |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Histiocyte                       |          1                                      2                        |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Histiocyte                      |       1                                                                  |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 4| 4| 6| 6| 7| 6| 5| 6| 6| 7| 6| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 3| 3| 3| 4| 8| 8| 3| 3| 2| 4| 5| 9| 3| 6| 8| 6| 9| 3| 8| 9| 9| 3| 3|             
                                           | 9| 9| 0| 0| 0| 5| 6| 8| 0| 0| 1| 8| 6| 5| 0| 5| 3| 7| 5| 0| 8| 5| 6| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    8  MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Pigmentation, Focal, Cholesterol     |                                                 2                        |             
      Pigmentation, Multifocal, Cholesterol|                                                                          |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |          1                                      2                        |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |                                                                          |             
      Fat, Mediastinum, Necrosis,          |                                                                          |             
          Multifocal                       |    2                 2                                                   |             
      Mediastinum, Foreign Body            |                                                                          |             
      Mediastinum, Inflammation, Chronic   |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                   2                                   2  2              2|             
      Fungus                               |                   2                                      2              3|             
      Inflammation, Acute, Suppurative     |                   2                                   2  2           2  2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Subacute                        | 2                                                                       2|             
      Submucosa, Foreign Body              |                         2                                                |             
      Submucosa, Inflammation, Chronic,    |                                                                          |             
           Focal                           |                         2                                                |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +           +                     |             
      Cataract                             |                                                    4                     |             
      Cornea, Cyst                         |                                        X                                 |             
      Retina, Degeneration                 |                                        4           4                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 3  4  4  3  4  2  3  3  3  2  2  2  4  3  4  4  3  3  4  3  4  3  3  4  4|             
      Cortex, Cyst, Multiple               |                                                                          |             
      Cortex, Fibrosis, Focal              |                                        3                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 6| 6| 7| 4| 6| 6| 7| 7| 6| 6| 7| 7| 7| 5| 5| 6| 6| 7| 0| 4| 6| 6| 6|            |
                             DAY ON TEST   | 5| 9| 9| 9| 3| 4| 8| 9| 2| 2| 2| 9| 3| 3| 3| 7| 9| 0| 9| 0| 5| 2| 1| 5| 6|            |
                                           | 6| 0| 4| 4| 0| 3| 0| 8| 3| 9| 4| 4| 0| 0| 0| 5| 1| 9| 5| 7| 2| 1| 7| 5| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    8  MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                           2  2                           |      6  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                  2                                       |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                                                          |      1     |
      Cyst Multilocular                    |       X     X           X  X        X  X  X           X  X               |     24     |
      Developmental Malformation           |                                           2                              |      1  2.0|
      Granuloma, Multiple                  |                                                                          |      1  2.0|
      Hemorrhage, Multifocal               |                         2  2        3                    2               |      5  2.2|
      Neovascularization                   |    2  2  2        2                                      2        3      |     15  2.1|
      Thrombosis                           |                               X                                   X      |      4     |
      Biliary Tract, Cyst, Multiple        | 3  4  4  4  4  3  4  4  4  4  4  4  4  4  4  4  4  4  4  4     3  4  4  4|     49  3.9|
      Biliary Tract, Fibrosis, Multifocal  | 4  4  4  4  4  3  4  4  4  4  4  4  4  4  4  4  4  4  4  4     3  4  4  4|     49  3.9|
      Biliary Tract, Hyperplasia,          |                                                                          |            |
          Multifocal                       | 4  4  4  4  4  3  4  4  4  4  4  4  4  4  4  4  4  4  4  4     3  4  4  4|     49  3.9|
      Biliary Tract, Inflammation, Chronic,|                                                                          |            |
           Multifocal                      | 4  4  4  4  4  3  4  4  4  4  4  4  4  4  4  4  4  4  4  4     3  4  4  4|     49  3.9|
      Biliary Tract, Metaplasia            | 3  4  4  4  4  3  4  4  4  4  4  4  4  4  4  4  4  4  4  4     3  4  4  4|     49  3.9|
      Centrilobular, Necrosis              |                2  2              2                                   2   |      9  2.0|
      Hepatocyte, Cytomegaly               | 3  4  4  4  4  3  4  4  4  4  3  4  4  3  4  3  3  4  4  4     3  4  3  4|     49  3.8|
      Hepatocyte, Degeneration, Multifocal | 2  3  3  4  4  3  4  3  3  3  4  3  4  3  3  3  3  3  4  4     2  3  3  3|     49  3.2|
      Hepatocyte, Hyperplasia, Multifocal, |                                                                          |            |
           Nodular                         | 4  4  4  4  4  3  4  4  4  4  4  4  4  4  4  4  4  4  4  4     3  4  4  4|     49  3.9|
      Hepatocyte, Necrosis, Multifocal     | 2  3  2  3  2  2  4  3  4  3  4  3  4  2  2  2  2  2  4  4     2  3  2  3|     49  2.6|
      Hepatocyte, Vacuolization Cytoplasmic| 3  4  3  4  3  3  4  4  3  3  4  4  4  2  3  3  3  3  4  4     2  4  3  3|     49  3.3|
      Kupffer Cell, Pigmentation,          |                                                                          |            |
          Multifocal                       | 2  2  2  2  2  2  2  2  2  2  2  2  3  2  2  2  2  2  2  2     2  3  2  2|     49  2.1|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +           +  +        +        +        +     +  +              +   |  14        |
      Pigmentation, Hemosiderin, Multifocal|                                              4                           |      3  2.7|
      Fat, Hemorrhage                      |                3                                                         |      1  3.0|
      Fat, Necrosis, Focal                 |                3                                   4                     |      6  3.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 6| 6| 7| 4| 6| 6| 7| 7| 6| 6| 7| 7| 7| 5| 5| 6| 6| 7| 0| 4| 6| 6| 6|            |
                             DAY ON TEST   | 5| 9| 9| 9| 3| 4| 8| 9| 2| 2| 2| 9| 3| 3| 3| 7| 9| 0| 9| 0| 5| 2| 1| 5| 6|            |
                                           | 6| 0| 4| 4| 0| 3| 0| 8| 3| 9| 4| 4| 0| 0| 0| 5| 1| 9| 5| 7| 2| 1| 7| 5| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    8  MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Fat, Necrosis, Multifocal            |                                                       4                  |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy, Focal                       |                                                                         2|      6  1.5|
      Atrophy, Multifocal                  |                                  1              2                        |      5  1.4|
      Hyperplasia, Focal                   |    2     2           2           2  2           2                        |     12  2.1|
      Hyperplasia                          |                                                                          |      1  2.0|
      Hyperplasia, Multifocal              |       2     2                                2                 2  2      |     10  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |          2  2                                            3               |      3  2.3|
      Hyperplasia                          |          2  2  2        2                 2              2               |      6  2.0|
      Hyperplasia, Squamous                |                                                                          |      1  3.0|
      Inflammation, Subacute               |          2                                               3               |      2  2.5|
      Ulcer                                |          4  3                                            4               |      3  3.7|
      Ulcer, Multiple                      |                                                                          |      3  2.7|
      Serosa, Fibrosis, Focal              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Edema                                |          2              2                                                |      2  2.0|
      Erosion                              |                                                                          |      1  2.0|
      Erosion, Multiple                    |                2                                                         |      1  2.0|
      Mineralization, Multifocal           |                2        2                                                |      2  2.0|
      Ulcer                                |                                                          3               |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |    2        3  2     2     2  2  3  2  2  1  2  3  2  3  2        2  2  2|     39  2.1|
      Mineralization, Multifocal           |                                                                          |      1  2.0|
      Thrombosis                           |                               X                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                                X         |      2  2.0|
      Focal Cellular Change                |                                                                   X      |      2     |
      Capsule, Fibrosis, Focal             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                         2                 2                    2         |      3  2.0|
      Hyperplasia, Multifocal              |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 6| 6| 7| 4| 6| 6| 7| 7| 6| 6| 7| 7| 7| 5| 5| 6| 6| 7| 0| 4| 6| 6| 6|            |
                             DAY ON TEST   | 5| 9| 9| 9| 3| 4| 8| 9| 2| 2| 2| 9| 3| 3| 3| 7| 9| 0| 9| 0| 5| 2| 1| 5| 6|            |
                                           | 6| 0| 4| 4| 0| 3| 0| 8| 3| 9| 4| 4| 0| 0| 0| 5| 1| 9| 5| 7| 2| 1| 7| 5| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    8  MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M|  43        |
      Hyperplasia                          |                         3                                2               |      6  2.2|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           |             3           4                 2                    4         |      8  3.3|
      Pars Distalis, Cyst                  |                            X              X                              |      4     |
      Pars Distalis, Hyperplasia, Focal    |                      1     2                                             |      6  2.0|
      Pars Distalis, Hyperplasia           |             2     3                                                      |      2  2.5|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |                         2                 3                    2     2   |      6  2.3|
      Pars Intermedia, Cyst                |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      C-Cell, Hyperplasia, Focal           |                                              2                           |      1  2.0|
      C-Cell, Hyperplasia                  |                                                                   2      |      1  2.0|
      Follicle, Cyst                       |       X                                   X                          X   |      6     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Acute, Focal,          |                                                                          |            |
          Suppurative                      |                                     2                                    |      3  2.7|
      Duct, Cyst                           |                                              X                           |      4     |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Acute, Suppurative     |                                                                4         |      1  4.0|
      Inflammation, Subacute               |                      2  3                 2     2  4                    2|     11  2.4|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                +         |   1        |
      Inflammation, Acute, Suppurative     |                                                                4         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                   3           4                                      2   |      3  3.0|
      Interstitial Cell, Hyperplasia       |                                                                         2|      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                              +                           |   1        |
      Polychromasia                        |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |    2     1  2        2  2           2  2  2  2     2  2  2        2      |     28  1.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 6| 6| 7| 4| 6| 6| 7| 7| 6| 6| 7| 7| 7| 5| 5| 6| 6| 7| 0| 4| 6| 6| 6|            |
                             DAY ON TEST   | 5| 9| 9| 9| 3| 4| 8| 9| 2| 2| 2| 9| 3| 3| 3| 7| 9| 0| 9| 0| 5| 2| 1| 5| 6|            |
                                           | 6| 0| 4| 4| 0| 3| 0| 8| 3| 9| 4| 4| 0| 0| 0| 5| 1| 9| 5| 7| 2| 1| 7| 5| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    8  MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pancreatic, Ectasia                  |       2     2     3     3        4  4     3     3  4  3  4        3     4|     24  3.2|
      Pancreatic, Hyperplasia              |       2     2                       3     2              3        2      |     10  2.6|
      Renal, Ectasia                       |                         4                                                |      3  3.7|
      Renal, Hyperplasia                   |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  M  +  +  M  +  +  M  M  +  +  +  +  M  +  +  M  +  +  M  M  M  M  +  +|  27        |
      Congestion                           |                               2                                          |      1  2.0|
      Hyperplasia                          |                                     2                                    |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  48        |
      Congestion                           |                               3                                          |      1  3.0|
      Ectasia                              |    2              2     2           2           2  2  3                 2|     13  2.2|
      Hyperplasia                          |                      2  2              2  2                              |      6  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M|  45        |
      Congestion                           |                               4  2                                       |      2  3.0|
      Ectasia                              |          2                       3  3  4  2     2  2              2      |     16  2.3|
      Hyperplasia                          |       2                             2  3  2                              |      9  2.1|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectasia                              |                      2  2                          2                     |      7  2.0|
      Hyperplasia                          |                                        2                                 |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |       2  2  3        1           3  2  2  2           2  2               |     25  2.0|
      Degeneration, Fatty, Multifocal      |                                                                          |      1  2.0|
      Fibrosis, Focal                      |                   3                       3           3                 3|      7  3.0|
      Hematopoietic Cell Proliferation     | 1  4  2  2           1  3     2  1  1  2     4        2  2        3      |     30  2.1|
      Necrosis, Focal                      |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M|  42        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Duct, Cyst                           |             X  X  X     X  X              X              X     X     X   |     20     |
      Duct, Hemorrhage, Focal              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Edema, Focal    |                      4                                                   |      3  4.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Focal, Subacute                 |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 6| 6| 7| 4| 6| 6| 7| 7| 6| 6| 7| 7| 7| 5| 5| 6| 6| 7| 0| 4| 6| 6| 6|            |
                             DAY ON TEST   | 5| 9| 9| 9| 3| 4| 8| 9| 2| 2| 2| 9| 3| 3| 3| 7| 9| 0| 9| 0| 5| 2| 1| 5| 6|            |
                                           | 6| 0| 4| 4| 0| 3| 0| 8| 3| 9| 4| 4| 0| 0| 0| 5| 1| 9| 5| 7| 2| 1| 7| 5| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    8  MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Fibrous Osteodystrophy               |          1              4                                3               |      4  2.3|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                              +                           |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                2         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                            2     3                          3            |      4  2.8|
      Foreign Body                         |                                                             3            |      2  2.5|
      Fungus                               |                                                                         3|      1  3.0|
      Granuloma, Multiple                  |                      2                       1  1                        |      9  1.2|
      Hemorrhage, Focal                    |                                                                          |      2  2.0|
      Hemorrhage, Multifocal               |                3                                                         |      1  3.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Histiocyte                       |                                        1                                 |      3  1.3|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Histiocyte                      |                      2     2     3                                       |      4  2.0|
      Inflammation, Focal, Granulomatous   |                                                                         3|      1  3.0|
      Pigmentation, Focal, Cholesterol     |                                                                          |      1  2.0|
      Pigmentation, Multifocal, Cholesterol|                      2                                                   |      1  2.0|
      Thrombosis                           |                               X                                          |      1     |
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                          3               |      3  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Multifocal                      |                            2                                             |      1  2.0|
      Fat, Mediastinum, Necrosis,          |                                                                          |            |
          Multifocal                       |             2              4           2                                 |      5  2.4|
      Mediastinum, Foreign Body            | 2                                                                        |      1  2.0|
      Mediastinum, Inflammation, Chronic   | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         | 2                                                                        |      5  2.0|
      Fungus                               |                                                                   3      |      4  2.5|
      Inflammation, Acute, Suppurative     | 2                                                                 2      |      7  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Subacute                        |                      2                                                   |      3  2.0|
      Submucosa, Foreign Body              |                                                                          |      1  2.0|
      Submucosa, Inflammation, Chronic,    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 6| 6| 7| 4| 6| 6| 7| 7| 6| 6| 7| 7| 7| 5| 5| 6| 6| 7| 0| 4| 6| 6| 6|            |
                             DAY ON TEST   | 5| 9| 9| 9| 3| 4| 8| 9| 2| 2| 2| 9| 3| 3| 3| 7| 9| 0| 9| 0| 5| 2| 1| 5| 6|            |
                                           | 6| 0| 4| 4| 0| 3| 0| 8| 3| 9| 4| 4| 0| 0| 0| 5| 1| 9| 5| 7| 2| 1| 7| 5| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    8  MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cataract                             |                                                                          |      1  4.0|
      Cornea, Cyst                         |                                                                          |      1     |
      Retina, Degeneration                 |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                     +                                    |   1        |
      Inflammation, Chronic, Focal         |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                         +|   1        |
      Inflammation, Subacute               |                                                                         2|      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 | 3  2  4  3  4     3  3  4  4  4  4  3  4  4  3  3  3  3  4     3  3  3  3|     48  3.3|
      Cortex, Cyst, Multiple               |                         X                                                |      1     |
      Cortex, Fibrosis, Focal              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 2| 6| 7| 7| 7| 0| 6| 6| 6| 7| 0| 3| 6| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 3| 3| 5| 2| 2| 2| 3| 5| 8| 0| 3| 3| 7| 3| 3| 8| 3| 4| 9| 1| 3| 3|             
                                           | 9| 3| 0| 0| 0| 6| 7| 5| 9| 0| 4| 8| 7| 0| 0| 0| 3| 4| 8| 0| 6| 4| 8| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    4  MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                           2                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                        2                 2               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Parasite Metazoan                    |                2                                         2               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Cyst Multilocular                    | X     X  X  X  X        X  X           X              X                  |             
      Developmental Malformation           | X                                                                        |             
      Granuloma, Multiple                  |       2                                                                 1|             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                                       2                  |             
      Hemorrhage, Multifocal               |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Neovascularization                   |          2  2              2        2  2                 2        2     2|             
      Thrombosis                           |                X           X                                             |             
      Biliary Tract, Cyst, Multiple        | 4  4  4  4  4  4  4  4  4  4     3  4  4  4     4  4  4  4     2  4  4  4|             
      Biliary Tract, Fibrosis, Multifocal  | 4  3  4  4  4  4  4  4  4  4  3  3  4  4  4     4  4  4  4     2  4  4  4|             
      Biliary Tract, Hyperplasia,          |                                                                          |             
          Multifocal                       | 4  3  4  4  4  4  4  4  4  4  3  3  4  4  4     4  4  4  4     2  4  4  4|             
      Biliary Tract, Inflammation, Chronic,|                                                                          |             
           Multifocal                      | 4  3  4  3  4  4  4  4  4  4  3  3  3  4  4     4  4  4  4     3  4  4  4|             
      Biliary Tract, Metaplasia            | 4  4  4  4  4  4  4  4  4  4  3  3  4  3  4     4  4  4  4     2  4  4  4|             
      Centrilobular, Necrosis              | 2                                                                        |             
      Hepatocyte, Cytomegaly               | 3  3  4  2  3  3  4  2  2  3     3  2  3  3     3  3  2  4        3  2  3|             
      Hepatocyte, Degeneration, Multifocal | 2  2  3  2  4  4  4  3  2  3     2  3  2  2     2  2  2  2        2  2  4|             
      Hepatocyte, Hyperplasia, Multifocal, |                                                                          |             
           Nodular                         | 2  3  4  4  3  4  4  2  2  2     3  3  4  4     3  4  3  4        2  2  4|             
      Hepatocyte, Necrosis, Multifocal     | 2  2  2  2  4  4  4  3  2  3     2  3  2  2     2  2  2  2        2  2  4|             
      Hepatocyte, Vacuolization Cytoplasmic| 2  3  4  3  4  3  4  4  2  2     3  3  3  3     4  2  3  3        3  3  3|             
      Kupffer Cell, Pigmentation,          |                                                                          |             
          Multifocal                       | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2     2  2  2  2     2  2  2  2|             
                                            __________________________________________________________________________|             
   Mesentery                               |    +           +     +                             +              +      |             
      Pigmentation, Hemosiderin, Multifocal|                                                                          |             
      Fat, Necrosis, Focal                 |    4                 3                             3                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 2| 6| 7| 7| 7| 0| 6| 6| 6| 7| 0| 3| 6| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 3| 3| 5| 2| 2| 2| 3| 5| 8| 0| 3| 3| 7| 3| 3| 8| 3| 4| 9| 1| 3| 3|             
                                           | 9| 3| 0| 0| 0| 6| 7| 5| 9| 0| 4| 8| 7| 0| 0| 0| 3| 4| 8| 0| 6| 4| 8| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    4  MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                           2                              |             
      Atrophy, Multifocal                  |             3                                                            |             
      Cyst Multilocular                    |             X                                                            |             
      Hyperplasia, Focal                   |       3                             2           2        2               |             
      Hyperplasia                          |                                                                          |             
      Hyperplasia, Multifocal              |          3                                            2                 3|             
      Inflammation, Chronic, Focal         |                                  2        2                              |             
      Pigmentation, Hemosiderin            |                3                                                         |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                               +                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                     4                                    |             
      Hyperplasia                          |                      3              4           4                        |             
      Inflammation, Subacute               |                      3              3           3                        |             
      Perforation                          |                      X                          4                        |             
      Ulcer                                |                                                                   4      |             
      Ulcer, Multiple                      |                                     4                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Erosion, Multiple                    |                      3                                                   |             
      Inflammation, Subacute               |                   3                                                      |             
      Mineralization, Multifocal           |                                                       2                  |             
      Ulcer                                |                   4                                                      |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2  2  2  2  3  2  2        1  2  3  2  2     2  2  1  2        1      |             
      Fibrosis, Focal                      |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |                                     X                 X              X   |             
      Hemorrhage                           |                                                                          |             
      Necrosis, Diffuse                    |                                                                          |             
      Left, Atrophy                        |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                       2                  |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 2| 6| 7| 7| 7| 0| 6| 6| 6| 7| 0| 3| 6| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 3| 3| 5| 2| 2| 2| 3| 5| 8| 0| 3| 3| 7| 3| 3| 8| 3| 4| 9| 1| 3| 3|             
                                           | 9| 3| 0| 0| 0| 6| 7| 5| 9| 0| 4| 8| 7| 0| 0| 0| 3| 4| 8| 0| 6| 4| 8| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    4  MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Multifocal              |                                  2                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Hyperplasia                          |             2                       2           2     3                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |             4  4     2     2        4           4     4        2     2   |             
      Pars Distalis, Cyst                  |    X                                   X              X  X               |             
      Pars Distalis, Hyperplasia, Focal    |                                  3                       2               |             
      Pars Distalis, Hyperplasia           |                                                                          |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |             2              2                    2                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |                                                 2                        |             
      C-Cell, Hyperplasia, Multifocal      |                            2                                             |             
      Follicle, Cyst                       |                                     X     X                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +|             
      Inflammation, Acute, Focal,          |                                                                          |             
          Suppurative                      |                                                                      2   |             
      Inflammation, Focal, Subacute        |                                                 4                        |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               | 2           3  2     2  2  2        3           4  3  3  2     3  2      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                     +           +                        |             
      Inflammation, Subacute               |                                     3           4                        |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    3                 3                                                   |             
      Interstitial Cell, Hyperplasia       |                2                                2                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                   +                                                      |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2     2  2  3                                      2  2               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Inflammation, Granulomatous|                                                                          |             
      Pancreatic, Ectasia                  | 3  2     4        2                 3              3  3              3   |             
      Pancreatic, Hyperplasia              |                                                                          |             
      Pancreatic, Inflammation,            |                                                                          |             
          Granulomatous                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 2| 6| 7| 7| 7| 0| 6| 6| 6| 7| 0| 3| 6| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 3| 3| 5| 2| 2| 2| 3| 5| 8| 0| 3| 3| 7| 3| 3| 8| 3| 4| 9| 1| 3| 3|             
                                           | 9| 3| 0| 0| 0| 6| 7| 5| 9| 0| 4| 8| 7| 0| 0| 0| 3| 4| 8| 0| 6| 4| 8| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    4  MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  M  M  +  M  +  M  M  +  +  +  +  +  +  +  +  M  M  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                2                 4  2                                    |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                        3           3     2               |             
      Inflammation, Granulomatous          |                                                                          |             
      Pigmentation, Hemosiderin            |                4                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                  2                                       |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |    2  2     2  1     2                 2  2     2        2     1     2  2|             
      Fibrosis, Focal                      | 3     3           2                                                      |             
      Hematopoietic Cell Proliferation     |    2  2  1  2  3     1              2  1  2           4              2  1|             
      Inflammation, Granulomatous          |                                                                          |             
      Capsule, Fibrosis, Multifocal        |                3                                                         |             
      Capsule, Pigmentation, Hemosiderin   |                2                                                         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Cyst                           |    X        X  X     X  X  X     X  X           X  X  X  X     X     X   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                   2      |             
      Foreign Body                         |                                                                   2      |             
      Inflammation, Focal, Subacute        |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                2         |             
      Hemorrhage, Multifocal               |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                               3                             3            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 2| 6| 7| 7| 7| 0| 6| 6| 6| 7| 0| 3| 6| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 3| 3| 5| 2| 2| 2| 3| 5| 8| 0| 3| 3| 7| 3| 3| 8| 3| 4| 9| 1| 3| 3|             
                                           | 9| 3| 0| 0| 0| 6| 7| 5| 9| 0| 4| 8| 7| 0| 0| 0| 3| 4| 8| 0| 6| 4| 8| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    4  MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Foreign Body                         |                               3              3              3            |             
      Granuloma, Multiple                  |    2                                               2  2                  |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Histiocyte                       |                                                       2                  |             
      Pigmentation, Focal, Cholesterol     |                                                       2                  |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |    3                                                                     |             
      Fat, Mediastinum, Necrosis,          |                                                                          |             
          Multifocal                       |                                     2                                    |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                        2        2                        |             
      Fungus                               |                                     2           3                        |             
      Inflammation, Acute, Suppurative     |                                     2  2        3                        |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute, Suppurative              |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Subacute                        |                                                                          |             
      Nasopharyngeal Duct, Cyst            |       X                                                                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 3  3  3  3  4  2  3  4  4  3     4  4  3  3  1  4  2  4  4     3  4  3  3|             
      Cortex, Cyst                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 5| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 4| 7| 1| 3| 3| 6| 2| 3| 3| 3| 8| 3| 3| 3| 3| 1| 2| 1| 3| 3|            |
                                           | 7| 0| 0| 0| 0| 1| 8| 3| 2| 2| 5| 9| 2| 2| 2| 9| 2| 2| 2| 2| 0| 0| 8| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    4  MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                         2                                2           2   |      4  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                                                                      2   |      3  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Fibrosis, Focal                      |                                        2                                 |      1  2.0|
      Parasite Metazoan                    |       2                             2                       2           2|      6  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                   4                                                      |      1  4.0|
      Basophilic Focus                     |             X                       X                                    |      2     |
      Cyst Multilocular                    | X  X  X     X                    X        X     X        X               |     17     |
      Developmental Malformation           |                   3                             X                        |      3  3.0|
      Granuloma, Multiple                  |    1  2     1              2  2     2  1                             1   |     10  1.5|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                2     2                                                   |      3  2.0|
      Hemorrhage, Multifocal               |                   4                                                      |      1  4.0|
      Necrosis, Focal                      |                   4                                                      |      1  4.0|
      Neovascularization                   |          2                 2        2     2     2                    2   |     14  2.0|
      Thrombosis                           |                   4                                                      |      3  4.0|
      Biliary Tract, Cyst, Multiple        | 3  4  4  4  3  3  3  4  4  4  4  4  4  3  3  3  4  4  4  4  3  4  4  4  3|     47  3.7|
      Biliary Tract, Fibrosis, Multifocal  | 3  4  4  3  4  4  4  4  4  3  4  4  3  3  3  4  4  4  4  4  3  3  4  4  4|     48  3.7|
      Biliary Tract, Hyperplasia,          |                                                                          |            |
          Multifocal                       | 3  4  4  3  4  3  4  3  4  3  4  4  4  3  3  4  4  4  4  4  3  3  4  4  4|     48  3.7|
      Biliary Tract, Inflammation, Chronic,|                                                                          |            |
           Multifocal                      | 3  4  4  3  4  3  4  3  4  3  4  4  4  3  3  4  4  4  4  4  3  3  4  4  3|     48  3.7|
      Biliary Tract, Metaplasia            | 3  4  4  3  3  3  3  4  4  4  4  4  4  4  4  3  4  4  4  4  3  4  4  4  3|     48  3.7|
      Centrilobular, Necrosis              |                   2  1                       2        2                  |      5  1.8|
      Hepatocyte, Cytomegaly               | 4  3  3  2  2  2  4  3  3  3  4  3  2  2  3  3  4  4  3  3  2  3  3  2  4|     46  2.9|
      Hepatocyte, Degeneration, Multifocal | 3  4  2  2  2  2  4  2  4  2  3  3  2  3  2  2  3  3  4  2  3  2  4  2  2|     46  2.6|
      Hepatocyte, Hyperplasia, Multifocal, |                                                                          |            |
           Nodular                         | 3  4  3  3  3  2  4  3  3  3  4  4  2  2  2  2  4  4  2  2  2  2  2  2  3|     46  3.0|
      Hepatocyte, Necrosis, Multifocal     | 2  2  2  2  2  2  4  2  4  2  3  3  2  2  2  2  3  3  4  2  2  2  3  2  2|     46  2.5|
      Hepatocyte, Vacuolization Cytoplasmic| 4  4  4  3  4  2  4  4  2  4  3  2  3  4  3     2  3  2  4  4  2  3  3  4|     45  3.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  68                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 5| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 4| 7| 1| 3| 3| 6| 2| 3| 3| 3| 8| 3| 3| 3| 3| 1| 2| 1| 3| 3|            |
                                           | 7| 0| 0| 0| 0| 1| 8| 3| 2| 2| 5| 9| 2| 2| 2| 9| 2| 2| 2| 2| 0| 0| 8| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    4  MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Kupffer Cell, Pigmentation,          |                                                                          |            |
          Multifocal                       | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|     48  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +           +              +  +  +        +              +      |  12        |
      Pigmentation, Hemosiderin, Multifocal|                      4                                                   |      1  4.0|
      Fat, Necrosis, Focal                 |          4                          4  3  4        4              3      |      9  3.6|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy, Focal                       |                                                                          |      1  2.0|
      Atrophy, Multifocal                  |                                  2                       2               |      3  2.3|
      Cyst Multilocular                    |                                                                          |      1     |
      Hyperplasia, Focal                   |             3        3                    2              2           2   |      9  2.3|
      Hyperplasia                          |                         3                                                |      1  3.0|
      Hyperplasia, Multifocal              |    2                                2                                   2|      6  2.3|
      Inflammation, Chronic, Focal         |                                                                          |      2  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis                       |                                                                          |      1  4.0|
      Hyperplasia                          | 4                                2                                3  2   |      7  3.1|
      Inflammation, Subacute               | 3                                2                                   2   |      6  2.7|
      Perforation                          | 4                                                                        |      3  4.0|
      Ulcer                                | 4                                                                 4      |      3  4.0|
      Ulcer, Multiple                      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |          2        2                                                      |      2  2.0|
      Erosion, Multiple                    |                                                                          |      1  3.0|
      Inflammation, Subacute               |                                                                          |      1  3.0|
      Mineralization, Multifocal           |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                +                    +                                    |   2        |
      Hemorrhage                           |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  2  2  2  2  2  2  2  2  2  2  2  2     1     2  2  2  2        1  2  2|     38  1.9|
      Fibrosis, Focal                      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 5| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 4| 7| 1| 3| 3| 6| 2| 3| 3| 3| 8| 3| 3| 3| 3| 1| 2| 1| 3| 3|            |
                                           | 7| 0| 0| 0| 0| 1| 8| 3| 2| 2| 5| 9| 2| 2| 2| 9| 2| 2| 2| 2| 0| 0| 8| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    4  MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Focal Cellular Change                |                      X                 X                          X     X|      7     |
      Hemorrhage                           |                                                                3         |      1  3.0|
      Necrosis, Diffuse                    |                                                                3         |      1  3.0|
      Left, Atrophy                        |                                                                2         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Hyperplasia                          |                                           2                              |      1  2.0|
      Hyperplasia, Multifocal              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |          2              2        2                    2           2  2   |     10  2.1|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Angiectasis           | 4  4        3     2  2  2                    3                    4  2   |     18  3.0|
      Pars Distalis, Cyst                  |                                                                          |      4     |
      Pars Distalis, Hyperplasia, Focal    |                2     2                                               2   |      5  2.2|
      Pars Distalis, Hyperplasia           |                         2  2                                             |      2  2.0|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia, Focal           |                                                                          |      1  2.0|
      C-Cell, Hyperplasia, Multifocal      |                                                                          |      1  2.0|
      Follicle, Cyst                       |                         X                                            X   |      4     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  46        |
      Inflammation, Acute, Focal,          |                                                                          |            |
          Suppurative                      |                                                                          |      1  2.0|
      Inflammation, Focal, Subacute        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Subacute               | 3        2  3     3  2           1     1  2  2        3  1        3  1   |     26  2.3|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                      +  +                                                |   4        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 5| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 4| 7| 1| 3| 3| 6| 2| 3| 3| 3| 8| 3| 3| 3| 3| 1| 2| 1| 3| 3|            |
                                           | 7| 0| 0| 0| 0| 1| 8| 3| 2| 2| 5| 9| 2| 2| 2| 9| 2| 2| 2| 2| 0| 0| 8| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    4  MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Subacute               |                         2                                                |      3  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                   3           2                                          |      4  2.8|
      Interstitial Cell, Hyperplasia       |                               2                                          |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                2     2                                                  1|      9  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inguinal, Inflammation, Granulomatous|                               2                                          |      1  2.0|
      Pancreatic, Ectasia                  |                         4     2     3                             3      |     12  2.9|
      Pancreatic, Hyperplasia              |                         3                                         2      |      2  2.5|
      Pancreatic, Inflammation,            |                                                                          |            |
          Granulomatous                    |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  M  +  +  +|  35        |
      Ectasia                              |                                  2                                   2   |      2  2.0|
      Inflammation, Granulomatous          |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  48        |
      Ectasia                              |       2     2                       2                    2               |      7  2.3|
      Hyperplasia, Lymphoid                |             2                                                            |      1  2.0|
      Hyperplasia                          |                                                          2               |      1  2.0|
      Inflammation, Granulomatous          |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  48        |
      Ectasia                              |                            2     2        2                          2   |      7  2.3|
      Inflammation, Granulomatous          |                               2                                          |      1  2.0|
      Pigmentation, Hemosiderin            |                      4                                                   |      2  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Ectasia                              |                                     2                                    |      2  2.0|
      Inflammation, Granulomatous          |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |    2  2  2  2        2  2  2  2     2  2  2                          2  2|     25  1.9|
      Fibrosis, Focal                      |                      3                          2  3              2      |      7  2.6|
      Hematopoietic Cell Proliferation     |    2  2  1  2  2     2  2  1  2     2  2  2                       2  2  2|     27  1.9|
      Inflammation, Granulomatous          |                               2                                          |      1  2.0|
      Capsule, Fibrosis, Multifocal        |                                                                          |      1  3.0|
      Capsule, Pigmentation, Hemosiderin   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  46        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 5| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 4| 7| 1| 3| 3| 6| 2| 3| 3| 3| 8| 3| 3| 3| 3| 1| 2| 1| 3| 3|            |
                                           | 7| 0| 0| 0| 0| 1| 8| 3| 2| 2| 5| 9| 2| 2| 2| 9| 2| 2| 2| 2| 0| 0| 8| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    4  MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Duct, Cyst                           | X           X  X  X  X  X  X     X           X        X  X     X  X  X  X|     29     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bacterium                            |                                                                          |      1  2.0|
      Foreign Body                         |                                                                          |      1  2.0|
      Inflammation, Focal, Subacute        |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                   2      |      2  2.0|
      Hemorrhage, Multifocal               |                                              4        3                  |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                             4            |      3  3.3|
      Foreign Body                         |                                                             2            |      4  2.8|
      Granuloma, Multiple                  |                                  1                                       |      4  1.8|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Histiocyte                       |                                                                          |      1  2.0|
      Pigmentation, Focal, Cholesterol     |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |    2                                      2                              |      3  2.3|
      Fat, Mediastinum, Necrosis,          |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                2                       2     2                    2      |      6  2.0|
      Fungus                               |                2  3                    2                          3      |      6  2.5|
      Inflammation, Acute, Suppurative     |                2  3                    2     2                    2      |      8  2.3|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute, Suppurative              |                                                          2               |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Subacute                        | 2                    2                                                   |      2  2.0|
      Nasopharyngeal Duct, Cyst            |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 5| 6| 6| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 4| 5| 6| 7| 7|            |
                             DAY ON TEST   | 2| 3| 3| 3| 3| 4| 7| 1| 3| 3| 6| 2| 3| 3| 3| 8| 3| 3| 3| 3| 1| 2| 1| 3| 3|            |
                                           | 7| 0| 0| 0| 0| 1| 8| 3| 2| 2| 5| 9| 2| 2| 2| 9| 2| 2| 2| 2| 0| 0| 8| 2| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    4  MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 | 4  3  3  4  3  3  4  2  4  3  3  4  3  3  3  3  4  4  4  4  1  3  4  4  4|     48  3.3|
      Cortex, Cyst                         |                                  X              X                        |      2     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Transitional Epithelium, Hyperplasia,|                                                                          |            |
           Focal                           |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 7| 0| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 6| 6| 2| 2| 2| 3| 2| 2| 2| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 8| 6| 8| 3| 3|             
                                           | 5| 0| 8| 9| 9| 5| 9| 9| 9| 9| 0| 2| 2| 2| 2| 4| 2| 2| 5| 5| 4| 0| 7| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2  MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Parasite Metazoan                    |                                  2                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                         2                                               2|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                         X     X        X  X        X  X  X           X  X|             
      Cyst Multilocular                    |                                           X                              |             
      Developmental Malformation           |                                                                          |             
      Granuloma, Multiple                  |          2              2        1  1  2        2  2     1           1  1|             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |             2                 2                                          |             
      Hemorrhage, Multifocal               |                                                                          |             
      Leukocytosis                         |                               2                                          |             
      Neovascularization                   |                                     2              2     2              2|             
      Biliary Tract, Cyst, Multiple        | 3  3  3  4  3     3  3  3  4  3  3  4  3  3  3  3  4  3  4     3  3  3  3|             
      Biliary Tract, Fibrosis, Multifocal  | 3  3  3  4  3     3  3  3  4  3  3  4  3  3  3  3  3  3  4     3  3  3  4|             
      Biliary Tract, Hyperplasia,          |                                                                          |             
          Multifocal                       | 3  3  3  3  3     3  3  3  4  3  3  4  3  3  3  3  3  3  4     3  3  3  3|             
      Biliary Tract, Inflammation, Chronic,|                                                                          |             
           Multifocal                      | 3  3  3  3  3     3  3  3  4  3  3  3  3  3  3  3  3  3  3     3  3  3  3|             
      Biliary Tract, Metaplasia            | 3  3  3  4  3     3  4  3  4  3  3  4  3  3  4  3  4  3  4     3  3  3  3|             
      Centrilobular, Necrosis              | 1  2              2           2                                   2      |             
      Hepatocyte, Cytomegaly               | 2  3  2  2  2     2  3  1  4  3  4  2  2  3  2  2  2  3  2        3  2  2|             
      Hepatocyte, Degeneration, Multifocal | 2  2  2  2  2     2  2  2  4  2  3  2  2  3  2  2  2  2  2     2  2  3  2|             
      Hepatocyte, Hyperplasia, Multifocal, |                                                                          |             
           Nodular                         |    3  2  2  2     2  2  2  4  2  3  3  2  3  2        3  1     2  2  2  2|             
      Hepatocyte, Necrosis, Multifocal     | 2  2  2  2  2     2  2  1  3  2  3  2  2  3  2  2  2     2     2  2  2  2|             
      Hepatocyte, Vacuolization Cytoplasmic| 2     3  2        4  2  3  3     3  3  3  3  2  2  2  2  3     2  2  3  3|             
      Kupffer Cell, Pigmentation,          |                                                                          |             
          Multifocal                       | 1  2  2  2  2     2  2  1  2  2  2  2  2  2  1  1  1  1  2     2  2  1  1|             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +        +           +                                   +  +  +      |             
      Foreign Body                         |                                                                          |             
      Inflammation, Acute, Suppurative     |                                                                          |             
      Fat, Necrosis, Focal                 |                         3                                   3  4         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 7| 0| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 6| 6| 2| 2| 2| 3| 2| 2| 2| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 8| 6| 8| 3| 3|             
                                           | 5| 0| 8| 9| 9| 5| 9| 9| 9| 9| 0| 2| 2| 2| 2| 4| 2| 2| 5| 5| 4| 0| 7| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2  MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |       2                                                                  |             
      Atrophy, Multifocal                  |    2                          2  2           2                 2         |             
      Hyperplasia, Focal                   |    2        2  2           2        2        2  2                        |             
      Hyperplasia                          |          2                                                               |             
      Hyperplasia, Multifocal              |       2                       2                       2  2               |             
      Artery, Inflammation, Subacute       |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Perforation                          |                                                                          |             
      Ulcer                                |                                                                          |             
      Artery, Inflammation, Subacute       |                                        3                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Aorta, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  2  2  2     1  2     2     2  2  2     2  2     2        2     2  2|             
      Mineralization, Multifocal           |                                                                          |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |                               X     X        X                       X  X|             
      Hematopoietic Cell Proliferation,    |                                                                          |             
           Multifocal                      |                                  2                                       |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia, Focal                   |                         2                       2        2              1|             
      Necrosis, Diffuse                    |                                                                   3      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |    2  2                       4           2  3  2  2           4  2     4|             
      Pars Distalis, Cyst                  |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 7| 0| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 6| 6| 2| 2| 2| 3| 2| 2| 2| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 8| 6| 8| 3| 3|             
                                           | 5| 0| 8| 9| 9| 5| 9| 9| 9| 9| 0| 2| 2| 2| 2| 4| 2| 2| 5| 5| 4| 0| 7| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2  MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |    2        2                             2           2           2      |             
      Pars Distalis, Necrosis              |                                                 2                        |             
      Pars Distalis, Pigmentation,         |                                                                          |             
          Hemosiderin                      |    2                                               2           2  2     1|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia, Focal           |                                                       2                  |             
      C-Cell, Hyperplasia                  |                                                                   2      |             
      C-Cell, Hyperplasia, Multifocal      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Focal,          |                                                                          |             
          Suppurative                      |                                                                          |             
      Inflammation, Focal, Subacute        |                                           2                              |             
      Duct, Cyst                           |                                           X           X                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               | 1  2  2  2        2           2              2  3     2  2     3        2|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                        2     2                    2      |             
      Interstitial Cell, Hyperplasia       |                   2           2                                2         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2              2  2                 2     2                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Ectasia                    |                               4                                          |             
      Inguinal, Hyperplasia                |                               3                                          |             
      Pancreatic, Ectasia                  |                                                       2                  |             
      Pancreatic, Hyperplasia              |                                                       2                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  M  M  +  +  +  +|             
      Ectasia                              |                                  2        2        2  2                  |             
      Hyperplasia, Lymphoid                |                               2                                          |             
      Hyperplasia                          |                                                       2                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Ectasia                              |             3              2                    1                    2   |             
      Hyperplasia                          |                                                 2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                      2                                                   |             
      Hyperplasia                          |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 7| 0| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 6| 6| 2| 2| 2| 3| 2| 2| 2| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 8| 6| 8| 3| 3|             
                                           | 5| 0| 8| 9| 9| 5| 9| 9| 9| 9| 0| 2| 2| 2| 2| 4| 2| 2| 5| 5| 4| 0| 7| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2  MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Congestion                           |       2                 2        2     2                 2           2  2|             
      Fibrosis, Focal                      |    3                 3                                                   |             
      Hematopoietic Cell Proliferation     |       2     3     2  1        3        1  1        1  3  2           2   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Cyst                           | X        X        X        X  X           X  X  X  X  X  X     X  X     X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Edema, Focal    |       2                                                                  |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Focal, Subacute                 |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                  2                                       |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Inflammation, Acute, Suppurative     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                3         |             
      Hemorrhage, Multifocal               |    4                                                                     |             
      Hydrocephalus                        |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                3                                                         |             
      Foreign Body                         |                3                                                         |             
      Granuloma, Multiple                  |                   1  1                                         1         |             
      Hemorrhage, Multifocal               |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Histiocyte                      |                      2                                                   |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                   2      |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Multifocal                      |                                              1                           |             
      Fat, Mediastinum, Necrosis,          |                                                                          |             
          Multifocal                       |                   2                                                      |             
      Smooth Muscle, Hyperplasia, Focal    |          2                                                               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 6| 7| 7| 0| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 6| 6| 2| 2| 2| 3| 2| 2| 2| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 8| 6| 8| 3| 3|             
                                           | 5| 0| 8| 9| 9| 5| 9| 9| 9| 9| 0| 2| 2| 2| 2| 4| 2| 2| 5| 5| 4| 0| 7| 5| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2  MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Foreign Body                         |                                                    2                     |             
      Fungus                               |    3                                                                     |             
      Hyperkeratosis, Focal                |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Acute, Suppurative     |    3                                               2                     |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute, Suppurative              |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Subacute                        | 2                          2                 2  2  2           2         |             
      Nasopharyngeal Duct, Fungus          |                                                                          |             
      Nasopharyngeal Duct, Hyperplasia     |                                                                          |             
      Nasopharyngeal Duct, Inflammation,   |                                                                          |             
           Acute, Suppurative              |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                                                            |             
      Cataract                             |             2                                                            |             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Acute, Suppurative               |                                                                          |             
      Retina, Degeneration                 |             4                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 2  3  2  2  3     2  3  2  2  2  3  3  3  2  4  3  2  3  3     4  3  2  4|             
      Cortex, Cyst                         |                                                                          |             
      Renal Tubule, Mineralization,        |                                                                          |             
          Multifocal                       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 6| 5| 6| 6| 0| 0| 6| 7| 7|            |
                             DAY ON TEST   | 6| 0| 3| 3| 3| 5| 3| 3| 3| 3| 7| 3| 3| 3| 3| 2| 6| 8| 2| 8| 2| 8| 0| 3| 3|            |
                                           | 0| 2| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 5| 5| 1| 0| 7| 9| 0| 9| 5| 2| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    2  MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Focal                    | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  49        |
      Diverticulum                         |                                                 4                        |      1  4.0|
      Parasite Metazoan                    |    2                                                                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  49        |
      Parasite Metazoan                    |       2  2                                2                             2|      6  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |    X  X  X  X        X  X  X           X     X     X                    X|     20     |
      Cyst Multilocular                    |                                                                          |      1     |
      Developmental Malformation           |                               3                             X  X         |      3  3.0|
      Granuloma, Multiple                  |    2     1  2     2  2  1  1     2     1  2                          2   |     21  1.6|
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                                                                   2      |      3  2.0|
      Hemorrhage, Multifocal               |                                     2                                    |      1  2.0|
      Leukocytosis                         |                                                                          |      1  2.0|
      Neovascularization                   |                                           2                          2   |      6  2.0|
      Biliary Tract, Cyst, Multiple        |    3  3  3  3     3  3  3  3  2  3  3  3  3  2  3  2  3  2        3  3  3|     44  3.0|
      Biliary Tract, Fibrosis, Multifocal  |    3  3  3  3     4  2  3  3  2  3  3  3  3  2  3  2  3  3        3  3  3|     44  3.0|
      Biliary Tract, Hyperplasia,          |                                                                          |            |
          Multifocal                       |    3  3  3  3     3  2  3  3  2  3  3  3  3  2  3  2  3  3        3  2  3|     44  3.0|
      Biliary Tract, Inflammation, Chronic,|                                                                          |            |
           Multifocal                      |    3  3  3  3     3  2  3  3  2  3  3  3  3  2  3  2  3  3        3  3  3|     44  2.9|
      Biliary Tract, Metaplasia            |    3  3  3  3     4  3  3  3  3  3  3  3  3  2  3  3  3  3        3  3  3|     44  3.2|
      Centrilobular, Necrosis              |                               2                          2               |      7  1.9|
      Hepatocyte, Cytomegaly               |    3  1  2  3     2     2        2  2  1  3                       2  1  2|     35  2.3|
      Hepatocyte, Degeneration, Multifocal |    2  1  2  2     2                 2     1           2  2           1   |     33  2.1|
      Hepatocyte, Hyperplasia, Multifocal, |                                                                          |            |
           Nodular                         |    3  1  2  3     2                 2  1  2              2              2|     30  2.2|
      Hepatocyte, Necrosis, Multifocal     |    2  1  2  2     2                 2     1           2  2           1   |     32  2.0|
      Hepatocyte, Vacuolization Cytoplasmic|    3  1  2  3     2  2  2  1  2  2  2  2  2  3     2  2  2           2  3|     39  2.4|
      Kupffer Cell, Pigmentation,          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  79                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 6| 5| 6| 6| 0| 0| 6| 7| 7|            |
                             DAY ON TEST   | 6| 0| 3| 3| 3| 5| 3| 3| 3| 3| 7| 3| 3| 3| 3| 2| 6| 8| 2| 8| 2| 8| 0| 3| 3|            |
                                           | 0| 2| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 5| 5| 1| 0| 7| 9| 0| 9| 5| 2| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    2  MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
          Multifocal                       |    2  1  2  2     2  1  1  1  2  1  1  1  1  2  1  1  1  1        1  1  1|     44  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                 +                 +        +     +|  12        |
      Foreign Body                         |                                                                   2      |      1  2.0|
      Inflammation, Acute, Suppurative     |                                                                   3      |      1  3.0|
      Fat, Necrosis, Focal                 |                      3                 3                 3              4|      7  3.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy, Focal                       |                         2                                                |      2  2.0|
      Atrophy, Multifocal                  |          2        2                                                      |      7  2.0|
      Hyperplasia, Focal                   |          2                 2     2  2                    2               |     12  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Hyperplasia, Multifocal              |    2  2     2        3                                            2      |      9  2.1|
      Artery, Inflammation, Subacute       |          4                                                               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |    +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |    2                          2                       3           2      |      4  2.3|
      Inflammation, Subacute               |                                                       2           2      |      2  2.0|
      Perforation                          |                                                                   4      |      1  4.0|
      Ulcer                                |                                                       3                  |      1  3.0|
      Artery, Inflammation, Subacute       |                                                                      2   |      2  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                          +               |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                    +                     |   1        |
      Aorta, Mineralization                |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       |       2  2  2     1  2  1  2     1     2  2  2  2        1               |     30  1.8|
      Mineralization, Multifocal           |                                                    4                     |      1  4.0|
      Thrombosis                           |                                           4                              |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Focal Cellular Change                |       X                                         X                        |      7     |
      Hematopoietic Cell Proliferation,    |                                                                          |            |
           Multifocal                      |                                                                   3      |      2  2.5|
      Hemorrhage                           | 2                                                                        |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  80                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 6| 5| 6| 6| 0| 0| 6| 7| 7|            |
                             DAY ON TEST   | 6| 0| 3| 3| 3| 5| 3| 3| 3| 3| 7| 3| 3| 3| 3| 2| 6| 8| 2| 8| 2| 8| 0| 3| 3|            |
                                           | 0| 2| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 5| 5| 1| 0| 7| 9| 0| 9| 5| 2| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    2  MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Focal                   |                         2           1     2                              |      7  1.7|
      Necrosis, Diffuse                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M|  47        |
      Hyperplasia                          |                   2                                2                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |       3                    2     3     2              4  3           2  2|     18  2.7|
      Pars Distalis, Cyst                  |                                        X                                 |      2     |
      Pars Distalis, Hyperplasia, Focal    |    2     2                    2        2        2                    2  2|     12  2.0|
      Pars Distalis, Necrosis              |                                                                          |      1  2.0|
      Pars Distalis, Pigmentation,         |                                                                          |            |
          Hemosiderin                      |       2                    1     2                    2                 2|     10  1.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia, Focal           |                         2                                                |      2  2.0|
      C-Cell, Hyperplasia                  |                                                                          |      1  2.0|
      C-Cell, Hyperplasia, Multifocal      |                   2                                                      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute, Focal,          |                                                                          |            |
          Suppurative                      |                                                    2              3      |      2  2.5|
      Inflammation, Focal, Subacute        |                                                                          |      1  2.0|
      Duct, Cyst                           |                   X                                      X        X      |      5     |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Subacute               |       3           1     1  3     3  1              2  2  2              2|     22  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |    3                                                                    2|      5  2.2|
      Interstitial Cell, Hyperplasia       |                               1                                          |      4  1.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                     2           2                 2      |      8  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  81                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 6| 5| 6| 6| 0| 0| 6| 7| 7|            |
                             DAY ON TEST   | 6| 0| 3| 3| 3| 5| 3| 3| 3| 3| 7| 3| 3| 3| 3| 2| 6| 8| 2| 8| 2| 8| 0| 3| 3|            |
                                           | 0| 2| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 5| 5| 1| 0| 7| 9| 0| 9| 5| 2| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    2  MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inguinal, Ectasia                    |                                                                          |      1  4.0|
      Inguinal, Hyperplasia                |                                                                          |      1  3.0|
      Pancreatic, Ectasia                  |             3     2                       2                              |      4  2.3|
      Pancreatic, Hyperplasia              |             2                             2                              |      3  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  +  M  M  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  M  M  M  +|  40        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Ectasia                              |                   2                                                     2|      6  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia                          |                                                       3                  |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Ectasia                              |                            1                                             |      5  1.8|
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                    3                     |      1  3.0|
      Congestion                           |    2                    1        1     2     2  2     1              2  2|     16  1.8|
      Fibrosis, Focal                      |                                     3                    2               |      4  2.8|
      Hematopoietic Cell Proliferation     |    1     2  2        1        2  1     1        2     2  2        3     1|     23  1.8|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                         X                                                |      2     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Duct, Cyst                           |    X  X                    X  X  X        X     X     X  X              X|     24     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Edema, Focal    |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Focal, Subacute                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                   +      |   1        |
      Inflammation, Acute, Suppurative     |                                                                   2      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  82                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 6| 5| 6| 6| 0| 0| 6| 7| 7|            |
                             DAY ON TEST   | 6| 0| 3| 3| 3| 5| 3| 3| 3| 3| 7| 3| 3| 3| 3| 2| 6| 8| 2| 8| 2| 8| 0| 3| 3|            |
                                           | 0| 2| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 5| 5| 1| 0| 7| 9| 0| 9| 5| 2| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    2  MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Compression                          |                                                                          |      1  3.0|
      Hemorrhage, Multifocal               |                                                                          |      1  4.0|
      Hydrocephalus                        |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           | 3              3                                   2        3  3         |      6  2.8|
      Foreign Body                         | 3              3                 2                          3  4         |      6  3.0|
      Granuloma, Multiple                  |                   2  2        1        2  2                              |      8  1.5|
      Hemorrhage, Multifocal               | 3                                                                        |      1  3.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Histiocyte                      |                                  2                                       |      2  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  1.0|
      Fat, Mediastinum, Necrosis,          |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Smooth Muscle, Hyperplasia, Focal    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Foreign Body                         |                               2                                          |      2  2.0|
      Fungus                               |                               3        2     3                          3|      5  2.8|
      Hyperkeratosis, Focal                |                                                                         2|      1  2.0|
      Hyperplasia, Squamous                |                                              4                           |      1  4.0|
      Inflammation, Acute, Suppurative     |    1                          2        2     3                          2|      7  2.1|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute, Suppurative              |                                        2                                 |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Subacute                        |             2                       2                    2               |      9  2.0|
      Nasopharyngeal Duct, Fungus          |                                              3                           |      1  3.0|
      Nasopharyngeal Duct, Hyperplasia     |                                              2                           |      1  2.0|
      Nasopharyngeal Duct, Inflammation,   |                                                                          |            |
           Acute, Suppurative              |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                               +                       +                  |   3        |
      Cataract                             |                                                       3                  |      2  2.5|
      Anterior Chamber, Inflammation,      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  83                                                               
NTP Experiment-Test: 05004-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                               FURAN                                           Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 08:02:07  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 7| 7| 0| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 6| 5| 6| 6| 0| 0| 6| 7| 7|            |
                             DAY ON TEST   | 6| 0| 3| 3| 3| 5| 3| 3| 3| 3| 7| 3| 3| 3| 3| 2| 6| 8| 2| 8| 2| 8| 0| 3| 3|            |
                                           | 0| 2| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 5| 5| 1| 0| 7| 9| 0| 9| 5| 2| 5| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    2  MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
          Acute, Suppurative               |                               2                                          |      1  2.0|
      Retina, Degeneration                 |                                                       3                  |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 |    4  4  3  2     3  3  3  3  1  3  3  2  3  1  3  2  4  3        3  2  2|     44  2.7|
      Cortex, Cyst                         |    X                                                                     |      1     |
      Renal Tubule, Mineralization,        |                                                                          |            |
          Multifocal                       |                                                    4                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  84                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.