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TDMS Study 05007-06 Pathology Tables

NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97
Route: DOSED FEED                                                                                                 Time: 07:32:44




       Facility:  Southern Research Institute

       Chemical CAS #:  9005-65-6

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 1| 4| 2| 2| 2| 2| 1| 2| 2| 2| 4| 7| 0| 1| 3| 1| 6| 3| 3| 3| 6| 6| 6| 6| 6|             
                                           | 4| 8| 9| 9| 9| 9| 0| 9| 9| 9| 6| 5| 9| 6| 0| 7| 2| 0| 0| 0| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATD                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leiomyosarcoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 | X  X  X              X           X     X     X  X                        |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                +  +        +                           |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |                                              X  X                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |                                                 X                        |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |                                                 X                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |                                                 X                        |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 | X  X                                            X                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Adenoma                              |                                                          X               |             
      Leukemia Mononuclear                 | X  X                                         X  X                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 | X  X                                         X  X                        |             
      Pheochromocytoma NOS                 |                      X           X                       X               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  M  +  +  M  +  +  +  M  +               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 | X                                                                        |             
      Pars Distalis, Adenoma               |    X  X  X     X  X  X     X     X  X  X     X     X     X               |             
      Pars Distalis, Carcinoma             |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |                                              X  X                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 1| 4| 2| 2| 2| 2| 1| 2| 2| 2| 4| 7| 0| 1| 3| 1| 6| 3| 3| 3| 6| 6| 6| 6| 6|             
                                           | 4| 8| 9| 9| 9| 9| 0| 9| 9| 9| 6| 5| 9| 6| 0| 7| 2| 0| 0| 0| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATD                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Intermedia, Adenoma             |                                           X                              |             
      Pars Intermedia, Carcinoma           |                                                                          |             
      Pars Intermedia, Leukemia Mononuclear|                                                 X                        |             
      Pars Nervosa, Leukemia Mononuclear   |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      C-Cell, Adenoma                      |                X                                                         |             
      C-Cell, Carcinoma                    |                                                                          |             
      Follicular Cell, Adenoma             |                                              X                           |             
      Follicular Cell, Carcinoma           |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Adenoma                              |                                                          X               |             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                                                 X                        |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |                                              X  X                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |                                              X                           |             
      Endometrium, Polyp Stromal           |                            X  X  X  X                                    |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                              +  +                        |             
      Leukemia Mononuclear                 |                                              X  X                        |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |    X                                         X  X                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                              X                           |             
      Mediastinal, Leukemia Mononuclear    |    X                                            X  X                     |             
      Pancreatic, Leukemia Mononuclear     |                                                 X                        |             
      Renal, Leukemia Mononuclear          |                                              X                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 | X                                            X  X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 | X  X                 X        X  X  X  X     X  X  X                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 | X  X  X              X           X     X     X  X                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +               |             
      Leukemia Mononuclear                 |                                  X           X  X                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 1| 4| 2| 2| 2| 2| 1| 2| 2| 2| 4| 7| 0| 1| 3| 1| 6| 3| 3| 3| 6| 6| 6| 6| 6|             
                                           | 4| 8| 9| 9| 9| 9| 0| 9| 9| 9| 6| 5| 9| 6| 0| 7| 2| 0| 0| 0| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATD                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Adenoma                              |                                                                          |             
      Fibroadenoma                         |          X     X  X  X  X  X  X        X  X     X  X  X  X               |             
      Leukemia Mononuclear                 |                                                 X                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Squamous Cell Carcinoma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Rhabdomyosarcoma                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Carcinoma, Deep Invasion, Metastatic,|                                                                          |             
           Pituitary Gland                 |                                                                          |             
      Leukemia Mononuclear                 | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Leukemia Mononuclear                 | X  X  X              X        X  X  X  X     X  X  X                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                 +                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 | X                                            X                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |                                                 X                        |             
      Transitional Epithelium, Papilloma   |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 | X  X  X              X        X  X  X  X     X  X  X                     |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 7| 1| 6| 7| 7| 7| 6| 6| 7| 7| 7| 3| 6| 6| 6| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 7| 9| 4| 3| 3| 9| 4| 0| 3| 3| 3| 4| 1| 3| 3| 6| 1| 3| 9| 3| 6| 6| 6| 6| 6|             
                                           | 3| 4| 5| 0| 0| 5| 4| 1| 0| 0| 1| 0| 0| 0| 0| 7| 7| 0| 9| 0| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATD                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leiomyosarcoma                       |                                              X                           |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 | X                    X     X  X     X                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +           +              +                                          |             
      Leukemia Mononuclear                 | X                                                                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 | X                                                                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |                               X                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |                               X                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 | X        X                    X                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 | X                       X  X  X     X                                    |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 | X                          X  X                                          |             
      Pheochromocytoma NOS                 |       X                                                  X               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  M  M  M  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               | X  X  X  X  X     X  X  X  X     X  X  X  X        X                     |             
      Pars Distalis, Carcinoma             |                                                       X                  |             
      Pars Distalis, Leukemia Mononuclear  | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 7| 1| 6| 7| 7| 7| 6| 6| 7| 7| 7| 3| 6| 6| 6| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 7| 9| 4| 3| 3| 9| 4| 0| 3| 3| 3| 4| 1| 3| 3| 6| 1| 3| 9| 3| 6| 6| 6| 6| 6|             
                                           | 3| 4| 5| 0| 0| 5| 4| 1| 0| 0| 1| 0| 0| 0| 0| 7| 7| 0| 9| 0| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATD                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Intermedia, Adenoma             |                                                                          |             
      Pars Intermedia, Carcinoma           |                                                 X                        |             
      Pars Intermedia, Leukemia Mononuclear| X                                                                        |             
      Pars Nervosa, Leukemia Mononuclear   | X                                                                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      C-Cell, Adenoma                      |                                                 X  X  X                  |             
      C-Cell, Carcinoma                    |          X                                                               |             
      Follicular Cell, Adenoma             |                                                                          |             
      Follicular Cell, Carcinoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Adenoma                              |                         X                                                |             
      Carcinoma                            |                      X           X              X     X  X               |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 | X  X        X                                                            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |                                                                          |             
      Endometrium, Polyp Stromal           |       X                    X        X        X  X                        |             
                                            __________________________________________________________________________|             
   Vagina                                  |                +  +           +              +  +  +                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 | X                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Lymphoma Malignant Mixed             |                   X                                                      |             
      Iliac, Leukemia Mononuclear          |                                                                          |             
      Mediastinal, Leukemia Mononuclear    | X                 X           X                                          |             
      Pancreatic, Leukemia Mononuclear     | X                                                                        |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 | X                          X  X                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 | X  X  X  X  X              X        X                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 | X                    X     X  X     X                                    |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 | X           X        X  X  X  X     X                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 7| 1| 6| 7| 7| 7| 6| 6| 7| 7| 7| 3| 6| 6| 6| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 7| 9| 4| 3| 3| 9| 4| 0| 3| 3| 3| 4| 1| 3| 3| 6| 1| 3| 9| 3| 6| 6| 6| 6| 6|             
                                           | 3| 4| 5| 0| 0| 5| 4| 1| 0| 0| 1| 0| 0| 0| 0| 7| 7| 0| 9| 0| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATD                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Adenoma                              |                                                 X                        |             
      Fibroadenoma                         |             X        X     X  X  X  X     X  X     X  X  X               |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Squamous Cell Carcinoma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                +                                                         |             
      Rhabdomyosarcoma                     |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Carcinoma, Deep Invasion, Metastatic,|                                                                          |             
           Pituitary Gland                 |                                                 X     X                  |             
      Leukemia Mononuclear                 | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Alveolar/Bronchiolar Adenoma         |                                  X                                       |             
      Leukemia Mononuclear                 | X  X  X  X  X        X  X  X  X     X  X                                 |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 | X                             X                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |                                                                          |             
      Transitional Epithelium, Papilloma   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 | X  X  X  X  X     X  X  X  X  X     X  X                                 |             
      Lymphoma Malignant Mixed             |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 7| 7| 7| 6| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 7| 3| 3| 3| 4| 1| 3| 3| 3|                                            |            |
                                           | 1| 5| 0| 0| 0| 5| 0| 0| 0| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    UNTREATD                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leiomyosarcoma                       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                   X        X                                             |         15 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +        +                                                            |  10        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          6 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |                            X                                             |         10 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          7 |
      Pheochromocytoma NOS                 |       X                                                                  |          6 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +                                             |  41        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   8                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 7| 7| 7| 6| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 7| 3| 3| 3| 4| 1| 3| 3| 3|                                            |            |
                                           | 1| 5| 0| 0| 0| 5| 0| 0| 0| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    UNTREATD                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Pars Distalis, Adenoma               | X  X  X  X  X  X  X  X  X  X                                             |         37 |
      Pars Distalis, Carcinoma             |                                                                          |          1 |
      Pars Distalis, Leukemia Mononuclear  |                                                                          |          3 |
      Pars Intermedia, Adenoma             |       X                                                                  |          2 |
      Pars Intermedia, Carcinoma           |                                                                          |          1 |
      Pars Intermedia, Leukemia Mononuclear|                                                                          |          2 |
      Pars Nervosa, Leukemia Mononuclear   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      C-Cell, Adenoma                      |          X                                                               |          5 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
      Follicular Cell, Adenoma             |                                                                          |          1 |
      Follicular Cell, Carcinoma           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  M  +  +  +                                             |  48        |
      Adenoma                              | X                                                                        |          3 |
      Carcinoma                            |             X        X                                                   |          7 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Endometrium, Polyp Stromal           |                                                                          |          9 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   6        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   2        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                            X                                             |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Iliac, Leukemia Mononuclear          |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          6 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   9                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 7| 7| 7| 6| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 7| 3| 3| 3| 4| 1| 3| 3| 3|                                            |            |
                                           | 1| 5| 0| 0| 0| 5| 0| 0| 0| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    UNTREATD                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          2 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X                    X                                             |         19 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X                    X                                             |         15 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  47        |
      Leukemia Mononuclear                 |                                                                          |         10 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Adenoma                              |                                                                          |          1 |
      Fibroadenoma                         |    X     X  X     X                                                      |         28 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Squamous Cell Carcinoma              |                   X                                                      |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Rhabdomyosarcoma                     |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Carcinoma, Deep Invasion, Metastatic,|                                                                          |            |
           Pituitary Gland                 |                                                                          |          2 |
      Leukemia Mononuclear                 |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Leukemia Mononuclear                 |       X                    X                                             |         24 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  10                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 7| 7| 7| 6| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 7| 3| 3| 3| 4| 1| 3| 3| 3|                                            |            |
                                           | 1| 5| 0| 0| 0| 5| 0| 0| 0| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |     A      |
    UNTREATD                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |     L      |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +  +              +                                             |   6        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Transitional Epithelium, Papilloma   |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X           X        X                                             |         26 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  11                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 6| 6| 6| 6| 1| 3| 3| 3| 3|             
                                           | 0| 2| 0| 0| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| 1| 3| 3| 3| 3| 3| 2| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Squamous Cell Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                                          |             
      Leukemia Mononuclear                 |       X     X                    X     X  X                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                      +   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |       X                                                                  |             
      Pheochromocytoma NOS                 |          X                                                     X        X|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  M  +  +  M  +  +  M  +  +                 M  +  +  M  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 6| 6| 6| 6| 1| 3| 3| 3| 3|             
                                           | 0| 2| 0| 0| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| 1| 3| 3| 3| 3| 3| 2| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma               |             X  X     X  X  X     X  X  X  X                 X  X     X  X|             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
      Pars Intermedia, Leukemia Mononuclear|                                                                          |             
      Pars Nervosa, Leukemia Mononuclear   |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Thymoma Malignant, Metastatic, Thymus|                                                                          |             
      C-Cell, Adenoma                      |       X                                                        X         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            | X                                                           X     X      |             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Carcinoma              |                                        X                                 |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Endometrium, Polyp Stromal           | X                 X  X                    X                       X      |             
      Endometrium, Sarcoma Stromal         |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                   +                                                      |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                                                          |             
      Inguinal, Leukemia Mononuclear       |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |       X     X                          X  X                              |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |       X     X                    X     X  X                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +                 +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 6| 6| 6| 6| 1| 3| 3| 3| 3|             
                                           | 0| 2| 0| 0| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| 1| 3| 3| 3| 3| 3| 2| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |       X                                                                  |             
      Thymoma Malignant                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Adenocarcinoma                       |                                                             X            |             
      Fibroadenoma                         | X     X  X  X           X  X  X  X        X                    X  X      |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Lipoma                               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |       X     X                    X        X                              |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Mucosa, Leukemia Mononuclear         |                                                                          |             
      Nasolacrimal Duct, Squamous Cell     |                                                                          |             
          Carcinoma                        |                                        X                                 |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Thymoma Malignant, Metastatic, Thymus|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +     +  +  +                                                            |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Adenoma                              |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 6| 6| 6| 6| 1| 3| 3| 3| 3|             
                                           | 0| 2| 0| 0| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| 1| 3| 3| 3| 3| 3| 2| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |       X     X                    X     X  X                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 6| 7| 7| 4| 4| 4| 4| 4| 3| 4| 6| 6| 7|             
                             DAY ON TEST   | 3| 3| 0| 0| 3| 6| 9| 9| 3| 3| 7| 1| 4| 1| 3| 6| 6| 6| 6| 6| 1| 3| 3| 4| 3|             
                                           | 5| 3| 0| 8| 1| 7| 4| 9| 1| 1| 1| 2| 0| 7| 1| 3| 3| 3| 3| 3| 6| 2| 4| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Squamous Cell Carcinoma              |                                                                X         |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  I  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  I  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 A  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Hepatocellular Adenoma               |          X                 X                                             |             
      Leukemia Mononuclear                 |       X  X        X              X     X                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X     X                                 |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X     X                                 |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X     X                                 |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X              X     X                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |          X        X              X     X                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X              X     X                                 |             
      Pheochromocytoma NOS                 |       X  X                             X                                 |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +                 M  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 6| 7| 7| 4| 4| 4| 4| 4| 3| 4| 6| 6| 7|             
                             DAY ON TEST   | 3| 3| 0| 0| 3| 6| 9| 9| 3| 3| 7| 1| 4| 1| 3| 6| 6| 6| 6| 6| 1| 3| 3| 4| 3|             
                                           | 5| 3| 0| 8| 1| 7| 4| 9| 1| 1| 1| 2| 0| 7| 1| 3| 3| 3| 3| 3| 6| 2| 4| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Adenoma               | X  X  X     X     X  X  X  X  X  X  X     X                       X     X|             
      Pars Distalis, Leukemia Mononuclear  |                                                                          |             
      Pars Intermedia, Leukemia Mononuclear|                                                                          |             
      Pars Nervosa, Leukemia Mononuclear   |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
      Thymoma Malignant, Metastatic, Thymus|                X                                                         |             
      C-Cell, Adenoma                      |                            X     X  X  X  X                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Adenoma                              |                                                                      X   |             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                                  X                                       |             
      Squamous Cell Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X              X                                       |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
      Endometrium, Polyp Stromal           |       X     X  X  X                 X                                X   |             
      Endometrium, Sarcoma Stromal         |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                         +        +                          +  +         |             
      Leukemia Mononuclear                 |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |          X        X              X     X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Axillary, Leukemia Mononuclear       |                                  X     X                                 |             
      Iliac, Leukemia Mononuclear          |                                  X                                       |             
      Inguinal, Leukemia Mononuclear       |                                  X                                       |             
      Mediastinal, Leukemia Mononuclear    |                   X                    X                                 |             
      Pancreatic, Leukemia Mononuclear     |                   X              X                                       |             
      Renal, Leukemia Mononuclear          |                                  X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X              X     X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X        X              X     X                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |          X        X              X     X                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +                 +  I  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 6| 7| 7| 4| 4| 4| 4| 4| 3| 4| 6| 6| 7|             
                             DAY ON TEST   | 3| 3| 0| 0| 3| 6| 9| 9| 3| 3| 7| 1| 4| 1| 3| 6| 6| 6| 6| 6| 1| 3| 3| 4| 3|             
                                           | 5| 3| 0| 8| 1| 7| 4| 9| 1| 1| 1| 2| 0| 7| 1| 3| 3| 3| 3| 3| 6| 2| 4| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |          X        X              X     X                                 |             
      Thymoma Malignant                    |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Fibroadenoma                         |    X     X        X  X  X  X        X  X                          X  X   |             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                             +            |             
      Lipoma                               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X        X              X     X                                 |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Mucosa, Leukemia Mononuclear         |                                  X                                       |             
      Nasolacrimal Duct, Squamous Cell     |                                                                          |             
          Carcinoma                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
      Thymoma Malignant, Metastatic, Thymus|                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +     +                 +                             +|             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |             +                                                            |             
      Adenoma                              |             X                                                            |             
      Squamous Cell Carcinoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X              X     X                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                  X                                       |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 6| 7| 7| 4| 4| 4| 4| 4| 3| 4| 6| 6| 7|             
                             DAY ON TEST   | 3| 3| 0| 0| 3| 6| 9| 9| 3| 3| 7| 1| 4| 1| 3| 6| 6| 6| 6| 6| 1| 3| 3| 4| 3|             
                                           | 5| 3| 0| 8| 1| 7| 4| 9| 1| 1| 1| 2| 0| 7| 1| 3| 3| 3| 3| 3| 6| 2| 4| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |       X  X        X              X     X                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 6| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 1| 3| 3| 3| 2| 9| 9| 1| 3|                                            |            |
                                           | 8| 9| 1| 1| 1| 3| 4| 8| 6| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    5.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hepatocellular Adenoma               |       X                                                                  |          3 |
      Leukemia Mononuclear                 | X     X                    X                                             |         13 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                                                      |   3        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 | X                                                                        |          3 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 | X                                                                        |          4 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 | X                                                                        |          6 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 | X                                                                        |          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  20                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 6| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 1| 3| 3| 3| 2| 9| 9| 1| 3|                                            |            |
                                           | 8| 9| 1| 1| 1| 3| 4| 8| 6| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    5.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pheochromocytoma NOS                 |       X                                                                  |          7 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +                                             |  41        |
      Adenoma                              |       X                                                                  |          1 |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Pars Distalis, Adenoma               |    X  X  X  X  X  X  X  X  X                                             |         36 |
      Pars Distalis, Leukemia Mononuclear  | X                                                                        |          1 |
      Pars Intermedia, Leukemia Mononuclear| X                                                                        |          1 |
      Pars Nervosa, Leukemia Mononuclear   | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Thymoma Malignant, Metastatic, Thymus|                                                                          |          1 |
      C-Cell, Adenoma                      |       X  X                 X                                             |         10 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Adenoma                              |       X        X                                                         |          3 |
      Carcinoma                            |                         X                                                |          4 |
      Leukemia Mononuclear                 | X                                                                        |          2 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 | X                                                                        |          3 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 | X                                                                        |          2 |
      Endometrium, Polyp Stromal           |                   X                                                      |         12 |
      Endometrium, Sarcoma Stromal         |                X                                                         |          1 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   5        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 | X                                                                        |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Axillary, Leukemia Mononuclear       |                                                                          |          2 |
      Iliac, Leukemia Mononuclear          |                                                                          |          1 |
      Inguinal, Leukemia Mononuclear       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  21                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 6| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 1| 3| 3| 3| 2| 9| 9| 1| 3|                                            |            |
                                           | 8| 9| 1| 1| 1| 3| 4| 8| 6| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    5.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Leukemia Mononuclear    | X     X                                                                  |          4 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          2 |
      Renal, Leukemia Mononuclear          |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 | X                          X                                             |          5 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 | X     X                    X                                             |         12 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 | X     X                    X                                             |         12 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  47        |
      Leukemia Mononuclear                 | X     X                                                                  |          7 |
      Thymoma Malignant                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Adenocarcinoma                       |                                                                          |          1 |
      Fibroadenoma                         |       X     X     X     X  X                                             |         26 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                      +                                                   |   2        |
      Lipoma                               |                      X                                                   |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 | X                                                                        |          2 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 | X     X                    X                                             |         12 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Mucosa, Leukemia Mononuclear         |                                                                          |          1 |
      Nasolacrimal Duct, Squamous Cell     |                                                                          |            |
          Carcinoma                        |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 | X                                                                        |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  22                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 6| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 1| 3| 3| 3| 2| 9| 9| 1| 3|                                            |            |
                                           | 8| 9| 1| 1| 1| 3| 4| 8| 6| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     A      |
    5.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Thymoma Malignant, Metastatic, Thymus|                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                +  +                                                      |  10        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                +                                                         |   2        |
      Adenoma                              |                                                                          |          1 |
      Squamous Cell Carcinoma              |                X                                                         |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 | X                                                                        |          4 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 | X                                                                        |          2 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 | X     X                    X                                             |         13 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  23                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 3| 3| 0| 2| 3| 3| 3| 6| 6| 6| 6| 6| 6| 8| 1| 3| 3| 1| 2| 0| 1| 3|             
                                           | 0| 8| 0| 1| 1| 0| 4| 1| 4| 4| 3| 3| 3| 3| 3| 7| 7| 7| 4| 4| 9| 3| 2| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                 A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                 A  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                 A  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                 A  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |                                                                          |             
      Histiocytic Sarcoma                  | X                                                                        |             
      Leukemia Mononuclear                 |                                                 X           X  X     X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  M  +  +  +  +  +                 A  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                 X                    X   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                                                 X                    X   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
      Pheochromocytoma NOS                 |             X  X                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 3| 3| 0| 2| 3| 3| 3| 6| 6| 6| 6| 6| 6| 8| 1| 3| 3| 1| 2| 0| 1| 3|             
                                           | 0| 8| 0| 1| 1| 0| 4| 1| 4| 4| 3| 3| 3| 3| 3| 7| 7| 7| 4| 4| 9| 3| 2| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  M  +  +  +  +  +                 A  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                      X                                                   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  M                 +  +  M  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X        X     X     X                       X  X  X  X  X  X     X  X|             
      Pars Distalis, Histiocytic Sarcoma   | X                                                                        |             
      Pars Distalis, Leukemia Mononuclear  |                                                 X                    X   |             
      Pars Intermedia, Leukemia Mononuclear|                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
      C-Cell, Adenoma                      |          X                                         X  X                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  M  +  +|             
      Adenoma                              |             X                                                            |             
      Carcinoma                            | X     X        X     X                                   X               |             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  | X                                                                        |             
      Leukemia Mononuclear                 |                                                 X                    X   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                      X   |             
      Endometrium, Polyp Stromal           |          X  X        X                       X                       X  X|             
                                            __________________________________________________________________________|             
   Vagina                                  |                                              +                 +     +   |             
      Leukemia Mononuclear                 |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +                                                                        |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  | X                                                                        |             
      Leukemia Mononuclear                 |                                                 X                    X   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                                                 X                    X   |             
      Pancreatic, Leukemia Mononuclear     |                                                 X                    X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                 X           X        X   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  | X                                                                        |             
      Leukemia Mononuclear                 |                                                 X                    X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 3| 3| 0| 2| 3| 3| 3| 6| 6| 6| 6| 6| 6| 8| 1| 3| 3| 1| 2| 0| 1| 3|             
                                           | 0| 8| 0| 1| 1| 0| 4| 1| 4| 4| 3| 3| 3| 3| 3| 7| 7| 7| 4| 4| 9| 3| 2| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  | X                                                                        |             
      Leukemia Mononuclear                 |                                                 X           X  X     X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  M  M  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                 X                    X   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                   X                                         X            |             
      Fibroadenoma                         |    X  X  X        X  X     X                    X     X  X     X  X  X   |             
      Leukemia Mononuclear                 |                                                                      X   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Head, Squamous Cell Papilloma        |                   X                                                      |             
      Subcutaneous Tissue, Fibroma         |                X                                                         |             
      Subcutaneous Tissue, Fibrosarcoma    |                   X                             X                        |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                      +   |             
      Leukemia Mononuclear                 |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Oligodendroglioma Malignant          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Leukemia Mononuclear                 |                                                 X           X  X     X   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +           +  +                          +           +      |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                 X                    X   |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 3| 3| 0| 2| 3| 3| 3| 6| 6| 6| 6| 6| 6| 8| 1| 3| 3| 1| 2| 0| 1| 3|             
                                           | 0| 8| 0| 1| 1| 0| 4| 1| 4| 4| 3| 3| 3| 3| 3| 7| 7| 7| 4| 4| 9| 3| 2| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  | X                                                                        |             
      Leukemia Mononuclear                 |                                                 X           X  X     X   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 2| 4| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 3| 6| 4| 3| 3| 3| 7| 6| 6| 3| 3| 3| 4| 3| 3| 3| 1| 3| 3| 3| 3|             
                                           | 2| 4| 4| 4| 4| 6| 0| 4| 4| 4| 3| 7| 1| 7| 4| 2| 0| 4| 4| 4| 0| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    2.5%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                  X                                       |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatocellular Adenoma               |    X                                                                     |             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                      X     X        X  X  X     X                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                             +  +           +                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X           X                        |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Tooth                                   |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X           X                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |             X              X                                             |             
      Leukemia Mononuclear                 |                                     X           X                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X           X                        |             
      Pheochromocytoma NOS                 |          X                                            X     X  X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 2| 4| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 3| 6| 4| 3| 3| 3| 7| 6| 6| 3| 3| 3| 4| 3| 3| 3| 1| 3| 3| 3| 3|             
                                           | 2| 4| 4| 4| 4| 6| 0| 4| 4| 4| 3| 7| 1| 7| 4| 2| 0| 4| 4| 4| 0| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    2.5%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X  X        X  X  X  X  X           X        X     X     X  X  X  X  X|             
      Pars Distalis, Histiocytic Sarcoma   |                                                                          |             
      Pars Distalis, Leukemia Mononuclear  |                            X        X                                    |             
      Pars Intermedia, Leukemia Mononuclear|                                     X                                    |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                 X                        |             
      C-Cell, Adenoma                      |                                           X                          X  X|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                           X                             X|             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                                     X                                    |             
      Squamous Cell Carcinoma              | X                                                                        |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                                             |             
      Endometrium, Polyp Stromal           |             X              X                       X        X     X      |             
                                            __________________________________________________________________________|             
   Vagina                                  |       +        +              +        +  +     +                        |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                                     X  X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Leukemia Mononuclear       |                            X                                             |             
      Mediastinal, Leukemia Mononuclear    |                                     X           X                        |             
      Pancreatic, Leukemia Mononuclear     |                                     X                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X        X  X        X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                      X     X        X  X        X                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 2| 4| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 3| 6| 4| 3| 3| 3| 7| 6| 6| 3| 3| 3| 4| 3| 3| 3| 1| 3| 3| 3| 3|             
                                           | 2| 4| 4| 4| 4| 6| 0| 4| 4| 4| 3| 7| 1| 7| 4| 2| 0| 4| 4| 4| 0| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    2.5%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                      X     X        X  X  X     X                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X        X           X                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
      Fibroadenoma                         | X        X        X        X           X  X  X              X     X  X  X|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                 X                        |             
      Head, Squamous Cell Papilloma        |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                         X|             
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             
      Subcutaneous Tissue, Lipoma          |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |    +                                            +                        |             
      Leukemia Mononuclear                 |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
      Oligodendroglioma Malignant          |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |       X                                                                  |             
      Leukemia Mononuclear                 |                            X        X  X        X                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +           +                                         +               |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                 X                        |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 2| 4| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 3| 6| 4| 3| 3| 3| 7| 6| 6| 3| 3| 3| 4| 3| 3| 3| 1| 3| 3| 3| 3|             
                                           | 2| 4| 4| 4| 4| 6| 0| 4| 4| 4| 3| 7| 1| 7| 4| 2| 0| 4| 4| 4| 0| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    2.5%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Leukemia Mononuclear                 |                      X     X        X  X  X     X                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 3| 6| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 2| 4| 1| 3| 3|                                            |            |
                                           | 3| 3| 3| 3| 3| 3| 6| 6| 4| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                M  +  +  +  +                                             |  48        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                +  +  +  +  +                                             |  48        |
      Adenocarcinoma                       |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                +  +  +  +  +                                             |  48        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                +  +  +  +  +                                             |  48        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   |                +  +  +  +  +                                             |  50        |
      Hepatocellular Adenoma               |                                                                          |          1 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |         10 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                +  +  +  +  +                                             |  47        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                +  +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  32                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 3| 6| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 2| 4| 1| 3| 3|                                            |            |
                                           | 3| 3| 3| 3| 3| 3| 6| 6| 4| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Adenoma                              |                                                                          |          2 |
      Leukemia Mononuclear                 |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Pheochromocytoma NOS                 |                                                                          |          6 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                +  +  +  +  +                                             |  47        |
      Adenoma                              |                            X                                             |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                M  M  +  +  +                                             |  41        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                +  +  +  +  +                                             |  50        |
      Pars Distalis, Adenoma               |                      X  X  X                                             |         30 |
      Pars Distalis, Histiocytic Sarcoma   |                                                                          |          1 |
      Pars Distalis, Leukemia Mononuclear  |                                                                          |          4 |
      Pars Intermedia, Leukemia Mononuclear|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      C-Cell, Adenoma                      |                                                                          |          6 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                +  +  +  +  +                                             |  49        |
      Adenoma                              |                                                                          |          3 |
      Carcinoma                            |                                                                          |          5 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                +  +  +  +  +                                             |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  |                +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Endometrium, Polyp Stromal           |                                                                          |         11 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   9        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                +  +  +  +  +                                             |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  33                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 3| 6| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 2| 4| 1| 3| 3|                                            |            |
                                           | 3| 3| 3| 3| 3| 3| 6| 6| 4| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +  +  +  +  +                                             |  50        |
      Axillary, Leukemia Mononuclear       |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                                                                          |          4 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          7 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                +  +  +  +  +                                             |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          7 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                +  +  +  +  +                                             |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |         10 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                +  +  +  M  +                                             |  46        |
      Leukemia Mononuclear                 |                                                                          |          5 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                +  +  +  +  +                                             |  48        |
      Adenocarcinoma                       |                                                                          |          2 |
      Fibroadenoma                         |                   X  X  X  X                                             |         27 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    |                +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Head, Squamous Cell Papilloma        |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          2 |
      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |          2 |
      Subcutaneous Tissue, Lipoma          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   3        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Oligodendroglioma Malignant          |                X                                                         |          2 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  34                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 3| 6| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 2| 4| 1| 3| 3|                                            |            |
                                           | 3| 3| 3| 3| 3| 3| 6| 6| 4| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |     A      |
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                +  +  +  +  +                                             |  50        |
      Alveolar/Bronchiolar Adenoma         |                   X                                                      |          1 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          8 |
                                            __________________________________________________________________________|____________|
   Nose                                    |                +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   9        |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |                +  +  +  +  +                                             |  50        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |         10 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  35                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 8| 2| 2| 2| 2| 9| 0| 2| 2| 2| 6| 6| 2| 2| 2| 6| 2| 2| 2| 2| 6| 6| 6| 6| 6|             
                                           | 5| 9| 9| 9| 9| 8| 1| 9| 9| 9| 1| 2| 3| 9| 9| 1| 9| 9| 9| 9| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Hepatocellular Adenoma               |                X                                                         |             
      Leukemia Mononuclear                 | X           X  X     X     X     X     X     X  X                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +  +                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |                                  X                                       |             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
      Acinus, Adenoma                      |       X                                                                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |                                  X                                       |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |          +                                            +                  |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |                            X                 X                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +               |             
      Adenoma                              |                                                                          |             
      Leukemia Mononuclear                 |                            X           X     X                           |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |                            X           X                                 |             
      Pheochromocytoma Malignant           |    X                                                                     |             
      Pheochromocytoma Benign              | X  X     X  X  X     X        X                 X     X                  |             
      Bilateral, Pheochromocytoma Benign   |                                  X                 X     X               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 8| 2| 2| 2| 2| 9| 0| 2| 2| 2| 6| 6| 2| 2| 2| 6| 2| 2| 2| 2| 6| 6| 6| 6| 6|             
                                           | 5| 9| 9| 9| 9| 8| 1| 9| 9| 9| 1| 2| 3| 9| 9| 1| 9| 9| 9| 9| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Adenoma                              |       X     X                                            X               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  +  +  +  +  M  +  +  M  +  M  +  +  +  +  +  +  M               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               | X           X     X  X  X     X     X  X  X     X                        |             
      Pars Intermedia, Adenoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      C-Cell, Adenoma                      |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Adenoma                              |    X                    X        X           X                           |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Interstitial Cell, Adenoma           |    X  X  X  X  X  X     X  X     X  X  X  X     X  X  X  X               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                  +                                       |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |                                              X                           |             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Mediastinal, Leukemia Mononuclear    |                                        X                                 |             
      Pancreatic, Leukemia Mononuclear     |                                        X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |                                  X                                       |             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |                                  X     X                                 |             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 | X           X  X     X     X     X     X     X                           |             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |                                  X                                       |             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
      Thymoma NOS                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 8| 2| 2| 2| 2| 9| 0| 2| 2| 2| 6| 6| 2| 2| 2| 6| 2| 2| 2| 2| 6| 6| 6| 6| 6|             
                                           | 5| 9| 9| 9| 9| 8| 1| 9| 9| 9| 1| 2| 3| 9| 9| 1| 9| 9| 9| 9| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +               |             
      Fibroadenoma                         |                   X                                                      |             
      Neurofibrosarcoma, Deep Invasion,    |                                                                          |             
           Metastatic, Skin                |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Keratoacanthoma                      |    X                                                                     |             
      Squamous Cell Papilloma              |                                        X                                 |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue,                 |                                                                          |             
          Neurofibrosarcoma                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Cranium, Osteosarcoma                |                                                                          |             
      Femur, Lymphoma Malignant Lymphocytic|                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Hemangioma                           |                                                       X                  |             
      Leukemia Mononuclear                 |                                                                          |             
      Neuroblastoma Malignant              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Alveolar/Bronchiolar Adenoma         |                               X                                          |             
      Leukemia Mononuclear                 | X              X     X     X     X     X     X                           |             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +           +                                                         |             
      Lids, Squamous Cell Carcinoma        |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 8| 2| 2| 2| 2| 9| 0| 2| 2| 2| 6| 6| 2| 2| 2| 6| 2| 2| 2| 2| 6| 6| 6| 6| 6|             
                                           | 5| 9| 9| 9| 9| 8| 1| 9| 9| 9| 1| 2| 3| 9| 9| 1| 9| 9| 9| 9| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 | X           X  X     X     X     X     X     X  X                        |             
      Lymphoma Malignant Lymphocytic       |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 7| 0| 2| 2| 2| 3| 8| 2| 2| 2| 2| 2| 3| 3| 3| 6| 6| 1| 8| 3| 6| 6| 6| 6| 6|             
                                           | 0| 0| 9| 9| 9| 0| 1| 9| 9| 9| 9| 9| 0| 0| 0| 4| 7| 4| 8| 0| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |          X                                               X               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Hepatocellular Adenoma               |    X                                                                     |             
      Leukemia Mononuclear                 | X  X     X     X  X  X           X        X  X           X               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +        +                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Acinus, Adenoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 | X  X                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 | X                                                                        |             
                                            __________________________________________________________________________|             
   Tongue                                  |          +                                                               |             
      Squamous Cell Papilloma              |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                      +     +  +                          +               |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 | X  X              X  X                                                   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Adenoma                              |       X                                                                  |             
      Leukemia Mononuclear                 |    X     X        X              X           X           X               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |    X              X              X           X           X               |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |    X  X  X  X     X     X                                                |             
      Bilateral, Pheochromocytoma Benign   |                                           X                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 7| 0| 2| 2| 2| 3| 8| 2| 2| 2| 2| 2| 3| 3| 3| 6| 6| 1| 8| 3| 6| 6| 6| 6| 6|             
                                           | 0| 0| 9| 9| 9| 0| 1| 9| 9| 9| 9| 9| 0| 0| 0| 4| 7| 4| 8| 0| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Adenoma                              |          X                                                               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  M  +  +  +  M  +  +  +  M  +  +  +               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |    X                                                                     |             
      Pars Distalis, Adenoma               |    X  X  X  X     X  X  X     X        X  X     X  X     X               |             
      Pars Intermedia, Adenoma             |       X                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      C-Cell, Adenoma                      |                         X        X        X                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +               |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +               |             
      Adenoma                              |                      X                                                   |             
      Carcinoma                            |             X           X                                X               |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +               |             
      Interstitial Cell, Adenoma           | X  X  X  X  X  X  X  X  X  X  X  X  X  X  X              X               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                +                                                         |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 | X                                            X                           |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Mediastinal, Leukemia Mononuclear    |    X  X                                                                  |             
      Pancreatic, Leukemia Mononuclear     | X     X                                      X                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 | X              X                             X                           |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 | X  X  X        X     X           X           X                           |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 | X  X  X  X     X  X  X           X        X  X           X               |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +               |             
      Leukemia Mononuclear                 |       X        X                 X                                       |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Thymoma NOS                          |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 7| 0| 2| 2| 2| 3| 8| 2| 2| 2| 2| 2| 3| 3| 3| 6| 6| 1| 8| 3| 6| 6| 6| 6| 6|             
                                           | 0| 0| 9| 9| 9| 0| 1| 9| 9| 9| 9| 9| 0| 0| 0| 4| 7| 4| 8| 0| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +               |             
      Fibroadenoma                         |                                                                          |             
      Neurofibrosarcoma, Deep Invasion,    |                                                                          |             
           Metastatic, Skin                |          X                                                               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Keratoacanthoma                      |                                           X                              |             
      Squamous Cell Papilloma              |                                  X                                       |             
      Subcutaneous Tissue, Fibroma         |                   X                                                      |             
      Subcutaneous Tissue,                 |                                                                          |             
          Neurofibrosarcoma                |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Cranium, Osteosarcoma                |                                                                          |             
      Femur, Lymphoma Malignant Lymphocytic|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Hemangioma                           |                                                                          |             
      Leukemia Mononuclear                 | X                                                                        |             
      Neuroblastoma Malignant              |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Leukemia Mononuclear                 | X  X  X  X     X  X  X           X        X  X           X               |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                  +                                       |             
                                            __________________________________________________________________________|             
   Eye                                     |             +     +     +              +        +                        |             
      Lids, Squamous Cell Carcinoma        |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Squamous Cell Carcinoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Carcinoma                            |                                                       X                  |             
      Leukemia Mononuclear                 | X                                            X                           |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                 +  +                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 7| 0| 2| 2| 2| 3| 8| 2| 2| 2| 2| 2| 3| 3| 3| 6| 6| 1| 8| 3| 6| 6| 6| 6| 6|             
                                           | 0| 0| 9| 9| 9| 0| 1| 9| 9| 9| 9| 9| 0| 0| 0| 4| 7| 4| 8| 0| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Leukemia Mononuclear                 | X  X  X  X     X  X  X           X        X  X           X               |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 6| 7| 7| 6| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 9| 4| 1| 3| 4| 1| 3| 3| 3|                                            |            |
                                           | 5| 3| 0| 7| 0| 0| 2| 0| 0| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  A  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |          X                                                               |          3 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hepatocellular Adenoma               |                                                                          |          2 |
      Leukemia Mononuclear                 |       X  X              X                                                |         22 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |          X                                                               |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Acinus, Adenoma                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  M  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Squamous Cell Papilloma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   6        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X  X              X                                                |          9 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Adenoma                              |                                                                          |          1 |
      Leukemia Mononuclear                 |       X  X                                                               |         11 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  44                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 6| 7| 7| 6| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 9| 4| 1| 3| 4| 1| 3| 3| 3|                                            |            |
                                           | 5| 3| 0| 7| 0| 0| 2| 0| 0| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Leukemia Mononuclear                 |       X  X                                                               |          9 |
      Pheochromocytoma Malignant           |                                                                          |          1 |
      Pheochromocytoma Benign              |       X                 X                                                |         17 |
      Bilateral, Pheochromocytoma Benign   |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Adenoma                              |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +                                             |  39        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Pars Distalis, Adenoma               | X  X        X     X  X  X  X                                             |         30 |
      Pars Intermedia, Adenoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      C-Cell, Adenoma                      |          X              X                                                |          6 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Adenoma                              |                                                                          |          5 |
      Carcinoma                            |       X  X                                                               |          5 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Interstitial Cell, Adenoma           |          X  X  X  X  X  X  X                                             |         39 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X  X                                                               |          5 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  M  +  +  +  +  +  +  +  +                                             |  49        |
      Mediastinal, Leukemia Mononuclear    |       X  X                                                               |          5 |
      Pancreatic, Leukemia Mononuclear     |       X  X                                                               |          6 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |       X  X                                                               |          6 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  45                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 6| 7| 7| 6| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 9| 4| 1| 3| 4| 1| 3| 3| 3|                                            |            |
                                           | 5| 3| 0| 7| 0| 0| 2| 0| 0| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |       X  X                                                               |         11 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X  X              X                                                |         22 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  47        |
      Leukemia Mononuclear                 |       X  X                                                               |          6 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Thymoma NOS                          |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  47        |
      Fibroadenoma                         |                                                                          |          1 |
      Neurofibrosarcoma, Deep Invasion,    |                                                                          |            |
           Metastatic, Skin                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Keratoacanthoma                      |                                                                          |          2 |
      Squamous Cell Papilloma              |                                                                          |          2 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |
      Subcutaneous Tissue,                 |                                                                          |            |
          Neurofibrosarcoma                |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Cranium, Osteosarcoma                | X                                                                        |          1 |
      Femur, Lymphoma Malignant Lymphocytic|                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hemangioma                           |                                                                          |          1 |
      Leukemia Mononuclear                 |       X                                                                  |          2 |
      Neuroblastoma Malignant              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          1 |
      Leukemia Mononuclear                 |          X              X                                                |         20 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  46                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 6| 7| 7| 6| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 9| 4| 1| 3| 4| 1| 3| 3| 3|                                            |            |
                                           | 5| 3| 0| 7| 0| 0| 2| 0| 0| 0|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |     A      |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |     L      |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +           +  +                                             |  10        |
      Lids, Squamous Cell Carcinoma        |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |       +                                                                  |   1        |
      Squamous Cell Carcinoma              |       X                                                                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Carcinoma                            |                                                                          |          1 |
      Leukemia Mononuclear                 |       X  X                                                               |          4 |
                                            __________________________________________________________________________|____________|
   Urethra                                 | +                                                                        |   3        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  A  +  +  +  +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X  X              X                                                |         23 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  47                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 6| 7| 7| 4| 5| 7| 7| 7| 5| 6| 6| 6| 7| 4| 4| 4| 4| 4| 4| 6| 6| 6| 7|             
                             DAY ON TEST   | 5| 8| 8| 3| 3| 5| 7| 0| 3| 3| 9| 4| 4| 6| 3| 6| 6| 6| 6| 6| 9| 4| 9| 9| 3|             
                                           | 4| 2| 8| 0| 0| 8| 5| 1| 0| 0| 7| 6| 6| 8| 0| 2| 2| 2| 2| 2| 4| 7| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Hemangiosarcoma, Metastatic, Spleen  |                                                             X            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Hepatocellular Adenoma               |                      X                                                   |             
      Leukemia Mononuclear                 |                      X     X        X                       X  X  X  X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +     +     +  +                       +     +      |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 M  +  +  +  +|             
      Acinus, Adenoma                      |                                                                         X|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                   +           +        +                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                      X              X                                X   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X              X                                X   |             
      Pheochromocytoma Malignant           |                                                                          |             
      Pheochromocytoma Benign              |    X  X     X                             X                    X        X|             
      Bilateral, Pheochromocytoma Benign   |          X                 X        X                                    |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 M  +  +  +  +|             
      Adenoma                              |             X                                                            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 6| 7| 7| 4| 5| 7| 7| 7| 5| 6| 6| 6| 7| 4| 4| 4| 4| 4| 4| 6| 6| 6| 7|             
                             DAY ON TEST   | 5| 8| 8| 3| 3| 5| 7| 0| 3| 3| 9| 4| 4| 6| 3| 6| 6| 6| 6| 6| 9| 4| 9| 9| 3|             
                                           | 4| 2| 8| 0| 0| 8| 5| 1| 0| 0| 7| 6| 6| 8| 0| 2| 2| 2| 2| 2| 4| 7| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               | X        X  X     X        X  X  X  X     X                       X     X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      C-Cell, Adenoma                      |                                                                          |             
      Follicle, Adenocarcinoma             |                                                                          |             
      Follicle, Adenoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Adenoma                              |    X        X                                                            |             
      Carcinoma                            |       X              X                                                   |             
      Squamous Cell Carcinoma              |                            X                                             |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Interstitial Cell, Adenoma           |    X  X  X        X  X  X  X  X  X  X  X  X                 X  X  X  X  X|             
      Tunic, Mesothelioma Benign           |                                                                         X|             
      Tunic, Mesothelioma Malignant        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                  +                                       |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |                                                                          |             
      Pancreatic, Leukemia Mononuclear     |                                                                          |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                   X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X     X                                X  X         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X     X        X                       X     X  X   |             
      Sarcoma                              |                                                             X            |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X     X                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 6| 7| 7| 4| 5| 7| 7| 7| 5| 6| 6| 6| 7| 4| 4| 4| 4| 4| 4| 6| 6| 6| 7|             
                             DAY ON TEST   | 5| 8| 8| 3| 3| 5| 7| 0| 3| 3| 9| 4| 4| 6| 3| 6| 6| 6| 6| 6| 9| 4| 9| 9| 3|             
                                           | 4| 2| 8| 0| 0| 8| 5| 1| 0| 0| 7| 6| 6| 8| 0| 2| 2| 2| 2| 2| 4| 7| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Basal Cell Carcinoma                 |                                                                          |             
      Keratoacanthoma                      |             X                 X  X        X                              |             
      Squamous Cell Papilloma              |                                                                          |             
      Subcutaneous Tissue, Fibroma         |    X                                      X                    X     X   |             
      Subcutaneous Tissue, Lipoma          |                                                                   X      |             
      Subcutaneous Tissue, Neurofibroma    |                                           X                              |             
      Subcutaneous Tissue,                 |                                                                          |             
          Neurofibrosarcoma                |                      X                                                   |             
      Subcutaneous Tissue, Sarcoma         |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Astrocytoma NOS                      |                                                                   X      |             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Leukemia Mononuclear                 |                X     X     X        X                       X  X  X  X  X|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Mucosa, Squamous Cell Carcinoma      |                                        X                                 |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                   +           +                                          |             
      Canal, Squamous Cell Carcinoma       |                   X           X                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +     +  +  +                                 |             
      Retina, Leukemia Mononuclear         |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |       +                    +                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 6| 7| 7| 4| 5| 7| 7| 7| 5| 6| 6| 6| 7| 4| 4| 4| 4| 4| 4| 6| 6| 6| 7|             
                             DAY ON TEST   | 5| 8| 8| 3| 3| 5| 7| 0| 3| 3| 9| 4| 4| 6| 3| 6| 6| 6| 6| 6| 9| 4| 9| 9| 3|             
                                           | 4| 2| 8| 0| 0| 8| 5| 1| 0| 0| 7| 6| 6| 8| 0| 2| 2| 2| 2| 2| 4| 7| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                X     X     X        X                       X  X  X  X  X|             
      Mesothelioma Benign                  |                                                                         X|             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 6| 7| 7| 6| 6| 7| 7| 7| 4| 5| 5| 7| 7| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 9| 9| 3| 3| 4| 8| 2| 3| 3| 6| 0| 7| 1| 3| 6| 6| 6| 6| 6| 7| 2| 0| 3| 3|             
                                           | 0| 9| 9| 1| 1| 4| 9| 4| 1| 1| 1| 3| 4| 0| 1| 2| 2| 2| 2| 2| 0| 5| 9| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Hemangiosarcoma, Metastatic, Spleen  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |          X              X                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Hepatocellular Adenoma               | X                                                                        |             
      Leukemia Mononuclear                 |       X  X     X     X  X        X  X  X                          X  X  X|             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +           +                                   +  +   |             
      Mesothelioma Malignant               |                                                                   X      |             
                                            __________________________________________________________________________|             
   Pancreas                                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Acinus, Adenoma                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                               +                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                X     X              X                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Carcinoma                            |                                                                   X      |             
      Leukemia Mononuclear                 |             X  X                    X  X                          X     X|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                    X  X                          X     X|             
      Pheochromocytoma Malignant           | X                                                                    X   |             
      Pheochromocytoma Benign              |          X  X  X     X  X  X           X                    X     X  X  X|             
      Bilateral, Pheochromocytoma Benign   |    X  X                                                                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Adenoma                              |             X              X                                             |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 6| 7| 7| 6| 6| 7| 7| 7| 4| 5| 5| 7| 7| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 9| 9| 3| 3| 4| 8| 2| 3| 3| 6| 0| 7| 1| 3| 6| 6| 6| 6| 6| 7| 2| 0| 3| 3|             
                                           | 0| 9| 9| 1| 1| 4| 9| 4| 1| 1| 1| 3| 4| 0| 1| 2| 2| 2| 2| 2| 0| 5| 9| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                                                                          |             
      Pars Distalis, Adenoma               |                   X  X     X     X     X  X                 X  X     X  X|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      C-Cell, Adenoma                      |                         X                                                |             
      Follicle, Adenocarcinoma             |                            X                                             |             
      Follicle, Adenoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                   X      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |       X                                                                  |             
      Squamous Cell Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                   X      |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Interstitial Cell, Adenoma           |    X  X  X  X  X  X  X  X  X        X  X  X                       X  X  X|             
      Tunic, Mesothelioma Benign           |                                                                          |             
      Tunic, Mesothelioma Malignant        |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |       X        X                 X  X  X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |       X                                                                  |             
      Pancreatic, Leukemia Mononuclear     |                X                    X                                    |             
      Renal, Leukemia Mononuclear          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                    X  X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +   |             
      Leukemia Mononuclear                 |       X  X     X     X              X  X                          X      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X  X  X     X  X        X  X  X                          X  X  X|             
      Sarcoma                              |                                                                         X|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                    X  X                          X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 6| 7| 7| 6| 6| 7| 7| 7| 4| 5| 5| 7| 7| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 9| 9| 3| 3| 4| 8| 2| 3| 3| 6| 0| 7| 1| 3| 6| 6| 6| 6| 6| 7| 2| 0| 3| 3|             
                                           | 0| 9| 9| 1| 1| 4| 9| 4| 1| 1| 1| 3| 4| 0| 1| 2| 2| 2| 2| 2| 0| 5| 9| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Basal Cell Carcinoma                 |    X                                                                     |             
      Keratoacanthoma                      |                                           X                              |             
      Squamous Cell Papilloma              |                                                                         X|             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Lipoma          |                                                             X            |             
      Subcutaneous Tissue, Neurofibroma    |                                                                          |             
      Subcutaneous Tissue,                 |                                                                          |             
          Neurofibrosarcoma                |                                                                          |             
      Subcutaneous Tissue, Sarcoma         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Astrocytoma NOS                      |                                                                          |             
      Leukemia Mononuclear                 |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma       |                                                                      X   |             
      Leukemia Mononuclear                 |       X  X  X  X     X  X        X  X  X                          X  X  X|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Mucosa, Squamous Cell Carcinoma      |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Canal, Squamous Cell Carcinoma       |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +        +           +  +                             +  +|             
      Retina, Leukemia Mononuclear         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                        X                                X|             
                                            __________________________________________________________________________|             
   Urethra                                 |                            +                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 6| 7| 7| 6| 6| 7| 7| 7| 4| 5| 5| 7| 7| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 9| 9| 3| 3| 4| 8| 2| 3| 3| 6| 0| 7| 1| 3| 6| 6| 6| 6| 6| 7| 2| 0| 3| 3|             
                                           | 0| 9| 9| 1| 1| 4| 9| 4| 1| 1| 1| 3| 4| 0| 1| 2| 2| 2| 2| 2| 0| 5| 9| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |       X  X  X  X     X  X        X  X  X                          X  X  X|             
      Mesothelioma Benign                  |                                                                          |             
      Mesothelioma Malignant               |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 2| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 0| 3| 3| 3| 5| 8| 7| 3| 3|                                            |            |
                                           | 7| 0| 1| 1| 1| 8| 2| 9| 1| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  A  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +                                             |  49        |
      Hemangiosarcoma, Metastatic, Spleen  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hepatocellular Adenoma               |                                                                          |          2 |
      Leukemia Mononuclear                 | X  X  X              X                                                   |         22 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +  +                                             |  12        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Acinus, Adenoma                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |       X                                                                  |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   4        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                      X                                                   |          5 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Carcinoma                            |                                                                          |          1 |
      Leukemia Mononuclear                 |    X  X                                                                  |         11 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |    X                                                                     |          9 |
      Pheochromocytoma Malignant           |                                                                          |          2 |
      Pheochromocytoma Benign              |    X        X     X     X                                                |         21 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  56                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 2| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 0| 3| 3| 3| 5| 8| 7| 3| 3|                                            |            |
                                           | 7| 0| 1| 1| 1| 8| 2| 9| 1| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Bilateral, Pheochromocytoma Benign   |          X           X                                                   |          7 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Adenoma                              |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  M  +  +  +  +  M  +                                             |  45        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |    X                                                                     |          1 |
      Pars Distalis, Adenoma               | X     X  X  X     X                                                      |         26 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      C-Cell, Adenoma                      |                         X                                                |          2 |
      Follicle, Adenocarcinoma             |                                                                          |          1 |
      Follicle, Adenoma                    |    X                                                                     |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Adenoma                              |                                                                          |          2 |
      Carcinoma                            |             X     X                                                      |          5 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Interstitial Cell, Adenoma           | X  X  X  X  X     X  X  X  X                                             |         41 |
      Tunic, Mesothelioma Benign           |                                                                          |          1 |
      Tunic, Mesothelioma Malignant        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  A  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 | X  X                                                                     |          7 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Axillary, Leukemia Mononuclear       |    X                                                                     |          1 |
      Mediastinal, Leukemia Mononuclear    |    X                                                                     |          2 |
      Pancreatic, Leukemia Mononuclear     | X  X                 X                                                   |          5 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  57                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 2| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 0| 3| 3| 3| 5| 8| 7| 3| 3|                                            |            |
                                           | 7| 0| 1| 1| 1| 8| 2| 9| 1| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Renal, Leukemia Mononuclear          | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Leukemia Mononuclear                 | X  X                 X                                                   |          7 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 | X  X  X              X                                                   |         15 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 | X  X  X              X                                                   |         22 |
      Sarcoma                              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 | X                    X                                                   |          8 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Basal Cell Carcinoma                 |                                                                          |          1 |
      Keratoacanthoma                      |                                                                          |          5 |
      Squamous Cell Papilloma              |                                                                          |          1 |
      Subcutaneous Tissue, Fibroma         |                                                                          |          4 |
      Subcutaneous Tissue, Lipoma          |                                                                          |          2 |
      Subcutaneous Tissue, Neurofibroma    |                                                                          |          1 |
      Subcutaneous Tissue,                 |                                                                          |            |
          Neurofibrosarcoma                |                                                                          |          1 |
      Subcutaneous Tissue, Sarcoma         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Astrocytoma NOS                      |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Leukemia Mononuclear                 | X  X  X           X  X                                                   |         26 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Mucosa, Squamous Cell Carcinoma      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  58                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 2| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 0| 3| 3| 3| 5| 8| 7| 3| 3|                                            |            |
                                           | 7| 0| 1| 1| 1| 8| 2| 9| 1| 1|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |     A      |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
      Canal, Squamous Cell Carcinoma       |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +     +           +     +                                             |  14        |
      Retina, Leukemia Mononuclear         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 | X  X  X              X                                                   |          6 |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  A  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                      X                                                   |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 | X  X  X           X  X                                                   |         26 |
      Mesothelioma Benign                  |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  59                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 4| 6| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 7| 4| 0| 3| 1| 9| 3| 3| 3| 6| 6| 6| 6| 6| 4| 0| 3| 3| 3| 0| 0| 0| 3| 3|             
                                           | 8| 7| 4| 0| 4| 3| 5| 4| 4| 4| 2| 2| 2| 2| 2| 0| 8| 4| 4| 4| 3| 6| 1| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  A  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  M  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X         |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  I  +  +  M  +|             
      Leukemia Mononuclear                 |                X                                               X         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X  X  X  X        X                    X  X        X  X        X|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                       +  +        +      |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                             X           X  X         |             
      Mesothelioma Malignant               |                                                                          |             
      Acinus, Adenoma                      |                                                                         X|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                             X  X         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X  X                                         X  X         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |             X  X  X                             X  X        X  X         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 4| 6| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 7| 4| 0| 3| 1| 9| 3| 3| 3| 6| 6| 6| 6| 6| 4| 0| 3| 3| 3| 0| 0| 0| 3| 3|             
                                           | 8| 7| 4| 0| 4| 3| 5| 4| 4| 4| 2| 2| 2| 2| 2| 0| 8| 4| 4| 4| 3| 6| 1| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |                X  X                             X  X        X  X         |             
      Pheochromocytoma Malignant           |       X                                            X                     |             
      Pheochromocytoma Benign              |             X  X                                         X        X      |             
      Bilateral, Pheochromocytoma Benign   |          X                                                               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |                                                                          |             
      Leukemia Mononuclear                 |                                                             X            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |    X     X  X     X        X                    X                 X     X|             
      Pars Distalis, Leukemia Mononuclear  |                X                                X           X  X         |             
      Pars Intermedia, Adenoma             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                                       X  X               |             
      Follicle, Adenoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
      Carcinoma                            |    X                                         X  X                       X|             
      Leukemia Mononuclear                 |                                                             X            |             
      Squamous Cell Carcinoma              |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X         |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                             X  X         |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Interstitial Cell, Adenoma           |       X     X  X  X  X  X                    X  X  X  X  X  X  X  X  X  X|             
      Tunic, Mesothelioma Malignant        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +                                                                     |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X  X                                         X  X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 4| 6| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 7| 4| 0| 3| 1| 9| 3| 3| 3| 6| 6| 6| 6| 6| 4| 0| 3| 3| 3| 0| 0| 0| 3| 3|             
                                           | 8| 7| 4| 0| 4| 3| 5| 4| 4| 4| 2| 2| 2| 2| 2| 0| 8| 4| 4| 4| 3| 6| 1| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Axillary, Leukemia Mononuclear       |                                                             X  X         |             
      Iliac, Leukemia Mononuclear          |                                                             X            |             
      Mediastinal, Leukemia Mononuclear    |       X     X  X  X                             X           X  X         |             
      Pancreatic, Leukemia Mononuclear     |                   X                                         X            |             
      Renal, Leukemia Mononuclear          |                                                             X            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X  X                             X           X  X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X     X  X  X                             X           X  X         |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X  X  X  X        X                    X  X        X  X        X|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  M                 M  M  +  M  +  +  +  +  +  M|             
      Leukemia Mononuclear                 |       X     X  X  X                                         X  X         |             
      Neoplasm NOS                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +                 +  +  +  M  +  +  +  +  M  +|             
      Fibroadenoma                         |                                                                   X      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |       X                                                                  |             
      Keratoacanthoma                      |                                                                          |             
      Subcutaneous Tissue, Fibroma         |                                                                          |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                             +            |             
      Leukemia Mononuclear                 |                                                             X            |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X  X                                         X  X         |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X  X  X  X                             X           X  X         |             
      Mesothelioma Malignant               |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 4| 6| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 7| 4| 0| 3| 1| 9| 3| 3| 3| 6| 6| 6| 6| 6| 4| 0| 3| 3| 3| 0| 0| 0| 3| 3|             
                                           | 8| 7| 4| 0| 4| 3| 5| 4| 4| 4| 2| 2| 2| 2| 2| 0| 8| 4| 4| 4| 3| 6| 1| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Pinna, Neurofibroma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +     +  +                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X  X                                         X  X         |             
                                            __________________________________________________________________________|             
   Urethra                                 | +              +                                                         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                X                                X           X  X         |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |       X  X  X  X  X        X                    X  X        X  X        X|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Mesothelioma Malignant               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 6| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 2| 7| 3| 3| 7| 2| 3| 3| 1| 1| 8| 3| 3| 3| 1| 5| 6| 3| 4| 9| 1| 3| 3|             
                                           | 9| 2| 4| 5| 4| 7| 7| 2| 4| 4| 6| 8| 3| 4| 4| 5| 7| 8| 7| 4| 6| 2| 0| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                                     |             
      Mesothelioma Malignant               |                X                                            X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                 X                          X              X         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
      Mesothelioma Malignant               |                                                             X            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X              X  X              X           X  X  X        X  X      |             
      Mesothelioma Malignant               |                                                             X            |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +        +           +                                +        +   |             
      Mesothelioma Malignant               |                X                                            X            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                 X                          X         |             
      Mesothelioma Malignant               |                X                                            X            |             
      Acinus, Adenoma                      |                                                                      X   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X              X                                    |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                X        X         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X              X  X              X           X     X        X  X      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 6| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 2| 7| 3| 3| 7| 2| 3| 3| 1| 1| 8| 3| 3| 3| 1| 5| 6| 3| 4| 9| 1| 3| 3|             
                                           | 9| 2| 4| 5| 4| 7| 7| 2| 4| 4| 6| 8| 3| 4| 4| 5| 7| 8| 7| 4| 6| 2| 0| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Leukemia Mononuclear                 |    X              X  X              X           X     X        X  X      |             
      Pheochromocytoma Malignant           |                   X     X                                                |             
      Pheochromocytoma Benign              |             X     X                       X              X  X            |             
      Bilateral, Pheochromocytoma Benign   |    X  X                                                                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Adenoma                              |       X                       X                    X           X         |             
      Carcinoma                            |                                                             X            |             
      Leukemia Mononuclear                 |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               | X  X     X     X              X  X           X     X  X  X  X  X     X  X|             
      Pars Distalis, Leukemia Mononuclear  |    X                                            X     X        X         |             
      Pars Intermedia, Adenoma             |       X                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Adenoma                      |                                                                          |             
      Follicle, Adenoma                    |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelioma Malignant               |                X                                                         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                X         |             
      Carcinoma                            |                                                          X               |             
      Leukemia Mononuclear                 |                                                                          |             
      Squamous Cell Carcinoma              |       X                                                                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                X                                            X            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
      Mesothelioma Malignant               |                X                                            X            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                                                X         |             
      Interstitial Cell, Adenoma           |       X     X     X     X  X  X        X  X     X     X  X  X  X  X  X   |             
      Tunic, Mesothelioma Malignant        |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +     +                                            +                  |             
      Leukemia Mononuclear                 |    X                                                  X                  |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X              X  X              X           X     X        X         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 6| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 2| 7| 3| 3| 7| 2| 3| 3| 1| 1| 8| 3| 3| 3| 1| 5| 6| 3| 4| 9| 1| 3| 3|             
                                           | 9| 2| 4| 5| 4| 7| 7| 2| 4| 4| 6| 8| 3| 4| 4| 5| 7| 8| 7| 4| 6| 2| 0| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Leukemia Mononuclear       |                                                                          |             
      Iliac, Leukemia Mononuclear          |                                                                          |             
      Mediastinal, Leukemia Mononuclear    |    X                                X           X     X        X         |             
      Pancreatic, Leukemia Mononuclear     |                                                 X     X        X         |             
      Renal, Leukemia Mononuclear          |                                                       X                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X              X  X              X                 X        X  X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X              X  X              X           X     X        X  X      |             
      Mesothelioma Malignant               |                                                             X            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X              X  X              X           X  X  X        X  X      |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X              X  X              X              X  X        X         |             
      Neoplasm NOS                         |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  +  +  M  +  M  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Fibroadenoma                         |          X                                                               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basal Cell Carcinoma                 |                                        X                                 |             
      Keratoacanthoma                      |       X                                               X                  |             
      Subcutaneous Tissue, Fibroma         |                            X  X                                          |             
      Subcutaneous Tissue, Lipoma          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                             +            |             
      Leukemia Mononuclear                 |                                                                          |             
      Mesothelioma Malignant               |                                                             X            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                      X                                                   |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X              X  X              X           X  X  X        X  X      |             
      Mesothelioma Malignant               |                                                             X            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 6| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 2| 7| 3| 3| 7| 2| 3| 3| 1| 1| 8| 3| 3| 3| 1| 5| 6| 3| 4| 9| 1| 3| 3|             
                                           | 9| 2| 4| 5| 4| 7| 7| 2| 4| 4| 6| 8| 3| 4| 4| 5| 7| 8| 7| 4| 6| 2| 0| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                               +                    +                     |             
      Pinna, Neurofibroma                  |                               X                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +  +     +           +     +                       +           +      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X                                                  X        X         |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Leukemia Mononuclear                 |    X              X  X              X           X  X  X        X  X      |             
      Lymphoma Malignant Mixed             |                                                                      X   |             
      Mesothelioma Malignant               |                X                                            X            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 6| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 3| 3| 8| 0| 3|                                            |            |
                                           | 2| 2| 2| 2| 2| 8| 5| 7| 1| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
      Mesothelioma Malignant               |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                +  +  +  +  +                                             |  49        |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                +  +  +  +  +                                             |  47        |
      Leukemia Mononuclear                 |                                                                          |          6 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   |                +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                      X                                                   |         21 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +           +                                             |  10        |
      Mesothelioma Malignant               |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          7 |
      Mesothelioma Malignant               |                                                                          |          2 |
      Acinus, Adenoma                      |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          4 |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          7 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  68                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 6| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 3| 3| 8| 0| 3|                                            |            |
                                           | 2| 2| 2| 2| 2| 8| 5| 7| 1| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |         15 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |         14 |
      Pheochromocytoma Malignant           |                                                                          |          4 |
      Pheochromocytoma Benign              |                   X  X     X                                             |         12 |
      Bilateral, Pheochromocytoma Benign   |                X                                                         |          4 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                +  +  +  +  +                                             |  48        |
      Adenoma                              |                   X                                                      |          5 |
      Carcinoma                            |                                                                          |          1 |
      Leukemia Mononuclear                 |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                +  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                +  +  +  +  +                                             |  49        |
      Pars Distalis, Adenoma               |                   X                                                      |         23 |
      Pars Distalis, Leukemia Mononuclear  |                                                                          |          8 |
      Pars Intermedia, Adenoma             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                +  +  +  +  +                                             |  50        |
      C-Cell, Adenoma                      |                                                                          |          2 |
      Follicle, Adenoma                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                +  +  +  +  +                                             |  50        |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                +  +  +  +  +                                             |  50        |
      Adenoma                              |                                                                          |          1 |
      Carcinoma                            |                X                                                         |          6 |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Squamous Cell Carcinoma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                |                +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          3 |
      Mesothelioma Malignant               |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  69                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 6| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 3| 3| 8| 0| 3|                                            |            |
                                           | 2| 2| 2| 2| 2| 8| 5| 7| 1| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Testes                                  |                +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Interstitial Cell, Adenoma           |                X     X  X  X                                             |         35 |
      Tunic, Mesothelioma Malignant        |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   4        |
      Leukemia Mononuclear                 |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |         11 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +  +  +  +  +                                             |  50        |
      Axillary, Leukemia Mononuclear       |                                                                          |          2 |
      Iliac, Leukemia Mononuclear          |                                                                          |          1 |
      Mediastinal, Leukemia Mononuclear    |                                                                          |         12 |
      Pancreatic, Leukemia Mononuclear     |                                                                          |          5 |
      Renal, Leukemia Mononuclear          |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |         12 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |         15 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                      X                                                   |         21 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                +  +  +  M  M                                             |  40        |
      Leukemia Mononuclear                 |                                                                          |         13 |
      Neoplasm NOS                         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                M  M  +  +  +                                             |  39        |
      Fibroadenoma                         |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Skin                                    |                +  +  +  +  +                                             |  50        |
      Basal Cell Carcinoma                 |                                                                          |          2 |
      Keratoacanthoma                      |                                                                          |          2 |
      Subcutaneous Tissue, Fibroma         |                      X                                                   |          3 |
      Subcutaneous Tissue, Lipoma          |                         X                                                |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                +  +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  70                                                               
NTP Experiment-Test: 05007-06                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/09/97  
Route: DOSED FEED                                                                                                 Time: 07:32:44  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 6| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 3| 3| 8| 0| 3|                                            |            |
                                           | 2| 2| 2| 2| 2| 8| 5| 7| 1| 4|                                            |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     O      |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |     A      |
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |     L      |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Leukemia Mononuclear                 |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          5 |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                      X                                                   |         18 |
      Mesothelioma Malignant               |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |                +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |                +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
      Pinna, Neurofibroma                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Eye                                     |                         +                                                |  11        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          7 |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                                                                          |          5 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |                +  +  +  +  +                                             |  50        |
      Leukemia Mononuclear                 |                      X                                                   |         21 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Mesothelioma Malignant               |                                                                          |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  71                                                               
                                  ------------------------------------------------------------                                      
                                  ----------              END OF REPORT             ----------                                      
                                  ------------------------------------------------------------