https://ntp.niehs.nih.gov/go/2760

TDMS Study 05007-06 Pathology Tables

NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97
Route: DOSED FEED                                                                                                 Time: 07:49:23
       Facility:  Southern Research Institute
       Chemical CAS #:  9005-65-6
       Lock Date:  None
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include All
                                                              Page   1
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 1| 4| 2| 2| 2| 2| 1| 2| 2| 2| 4| 7| 0| 1| 3| 1| 6| 3| 3| 3| 6| 6| 6| 6| 6|             
                                           | 4| 8| 9| 9| 9| 9| 0| 9| 9| 9| 6| 5| 9| 6| 0| 7| 2| 0| 0| 0| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATD                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Inflammation, Acute                  |                                                                          |             
      Parasite Metazoan                    |          X              X     X                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Parasite Metazoan                    |                      X                    X                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Parasite Metazoan                    |       X                       X        X                 X               |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Angiectasis                          |                      2              2                    2               |             
      Basophilic Focus                     |       X  X  X  X  X  X  X  X     X  X  X  X     X  X  X  X               |             
      Developmental Malformation           |             X                       X  X                                 |             
      Fatty Change                         |                1                                                         |             
      Granuloma                            |             3  2           2        2                                    |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Necrosis                             |                                        2                                 |             
      Bile Duct, Hyperplasia               |       1     1           2     1  1  1  1        3                        |             
      Hepatocyte, Hyperplasia              |                                                                          |             
      Portal, Inflammation, Chronic        |       2     1     2  1  2                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                +  +        +                           |             
      Fat, Inflammation, Acute             | 4                                                                        |             
      Fat, Necrosis                        |                                  3  3        4                           |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Acinus, Atrophy                      |    2  1                 1        2        4  2     1  1                  |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Inflammation, Acute                  | 2                                                                        |             
      Acinus, Atrophy                      |                                                                          |             
      Acinus, Hyperplasia                  |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Hyperkeratosis                       |    2                                                                     |             
      Inflammation, Acute                  |    2                                                                     |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 1| 4| 2| 2| 2| 2| 1| 2| 2| 2| 4| 7| 0| 1| 3| 1| 6| 3| 3| 3| 6| 6| 6| 6| 6|             
                                           | 4| 8| 9| 9| 9| 9| 0| 9| 9| 9| 6| 5| 9| 6| 0| 7| 2| 0| 0| 0| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATD                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                                                    3                     |             
      Mucosa, Dilatation                   |    2  2     2  2  2  2  2  2  1  2     2  2  2  2  2  2  2               |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                  +                                       |             
      Peridontal Tissue, Hemorrhage        |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Cardiomyopathy, Chronic              |       2  2  2  1  1  2  2  2  2  2  2  2  2  1  2  2  2  2               |             
      Hemorrhage                           |                                                                          |             
      Coronary Artery, Mineralization      |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                                                          |             
      Degeneration, Fatty                  |    3  1  3                    3        2  2  2        2  2               |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |       1                                            2                     |             
      Hypertrophy                          |                   2                                      1               |             
      Pigmentation                         |       1     1     1        1     1  1  2  1                              |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                2  1                 2  2           2                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  M  +  +  M  +  +  +  M  +               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Pars Distalis, Cyst                  |       X              X  X     X                 X  X  X                  |             
      Pars Distalis, Hyperplasia           |       2              2                                2                  |             
      Pars Distalis, Metaplasia, Osseous   |                                                                          |             
      Pars Intermedia, Cyst                |                                                 X                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      C-Cell, Hyperplasia                  |    2  2  2        2  1  2  2  1     1  2  1  3  1  1     1               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Abscess                              |                                                                          |             
      Inflammation, Chronic                |       1              1                 2  1        3                     |             
      Inflammation, Chronic Active         |                                           1        3     2               |             
      Duct, Ectasia                        |       3              3  3                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 1| 4| 2| 2| 2| 2| 1| 2| 2| 2| 4| 7| 0| 1| 3| 1| 6| 3| 3| 3| 6| 6| 6| 6| 6|             
                                           | 4| 8| 9| 9| 9| 9| 0| 9| 9| 9| 6| 5| 9| 6| 0| 7| 2| 0| 0| 0| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATD                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Ectasia                              |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |    2                       3                             2               |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                              +  +                        |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Mediastinal, Congestion              |          3                                                               |             
      Mediastinal, Hyperplasia, Lymphoid   |    3              2        2                             2               |             
      Mediastinal, Hyperplasia, Reticulum  |                                                                          |             
          Cell                             |       2                                                                  |             
      Pancreatic, Congestion               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Hyperplasia, Lymphoid                |          2  2  3  2     2     2  2  2  2  2           2  2               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |       2  2     3           2     2  2     3        2  2  2               |             
      Hyperplasia, Reticulum Cell          |       2                                                                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Hematopoietic Cell Proliferation     |          2  2  2  3  2  3  2  3  2  2  2  3  3     3  2  3               |             
      Hyperplasia, Histiocytic, Lymphoid   |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         |       2  3  3  3  2  2  2  3  3  3  3  2  3        2  2  3               |             
      Capsule, Fibrosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +               |             
      Cyst                                 |                                                          X               |             
      Hemorrhage                           | 4                                                                        |             
      Hyperplasia, Lymphoid                |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Acinus, Ectasia                      | 2  3  4  4  3  3  3  3  3  2  2  4  4  3  2  2  3  4  3  4               |             
      Acinus, Hyperplasia                  |                                  4  2                                    |             
      Duct, Ectasia                        |                   3  3           4     3           4  3                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Cyst Epithelial Inclusion            |                                  X  X                                    |             
      Inflammation, Chronic Active         |                2                                         2               |             
      Inflammation, Suppurative            |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 1| 4| 2| 2| 2| 2| 1| 2| 2| 2| 4| 7| 0| 1| 3| 1| 6| 3| 3| 3| 6| 6| 6| 6| 6|             
                                           | 4| 8| 9| 9| 9| 9| 0| 9| 9| 9| 6| 5| 9| 6| 0| 7| 2| 0| 0| 0| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATD                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Cranium, Fibrous Osteodystrophy      |                                  4                                       |             
      Cranium, Osteopetrosis               |                   3           3                                          |             
      Femur, Fibrous Osteodystrophy        |                                  4                                       |             
      Femur, Osteopetrosis                 |                   3                                                      |             
      Rib, Hyperplasia                     |                                     2                                    |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Compression                          |                X                 X  X  X                                 |             
      Hemorrhage                           |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Congestion                           |                                     2                                    |             
      Hemorrhage                           |       1           1  2                       2           2               |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |       2  2  1  1  2     2  2     1  1  1           2  2  2               |             
      Arteriole, Mineralization            |    2     2  1              2  2  2  2  1     2           2               |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Lumen, Hemorrhage                    |          2  2  1  2  2     1        1     1        1  2  1               |             
      Mucosa, Cyst                         |                      X                                                   |             
      Mucosa, Inflammation, Acute          |             2           4                                                |             
      Nasolacrimal Duct, Hemorrhage        |                                        2                                 |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           | 2              2  2           2        3                 2               |             
      Olfactory Epithelium, Degeneration   | 2  2  2     2  2  2  2     2  2  2  2  2  2  2  2  2  2  2               |             
      Respiratory Epithelium, Degeneration | 2  2  1     1     2  1     1           1     1  1  2     2               |             
      Vomeronasal Organ, Inflammation,     |                                                                          |             
           Acute                           |                2                                                         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                 +                                          |             
      Cataract                             |             3                                                            |             
      Hemorrhage                           |                                                                          |             
      Synechia                             |                                                                          |             
      Retina, Degeneration                 |             4                 4                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 1| 4| 2| 2| 2| 2| 1| 2| 2| 2| 4| 7| 0| 1| 3| 1| 6| 3| 3| 3| 6| 6| 6| 6| 6|             
                                           | 4| 8| 9| 9| 9| 9| 0| 9| 9| 9| 6| 5| 9| 6| 0| 7| 2| 0| 0| 0| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATD                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Nephropathy, Chronic                 |    2  2  3  2  3  3  2  2  2  3  4  3  2  2  2  2  2  2  3               |             
      Renal Tubule, Pigmentation           |    1  2  2  2  2  2  2  1  2  2  2  2  2  2  3  2  1  2  2               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Mineralization                       |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 7| 1| 6| 7| 7| 7| 6| 6| 7| 7| 7| 3| 6| 6| 6| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 7| 9| 4| 3| 3| 9| 4| 0| 3| 3| 3| 4| 1| 3| 3| 6| 1| 3| 9| 3| 6| 6| 6| 6| 6|             
                                           | 3| 4| 5| 0| 0| 5| 4| 1| 0| 0| 1| 0| 0| 0| 0| 7| 7| 0| 9| 0| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATD                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Inflammation, Acute                  |                            4                                             |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Parasite Metazoan                    |                                  X                                       |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |    X  X  X  X     X  X  X  X     X  X  X  X     X  X  X  X               |             
      Developmental Malformation           |    X           X                                                         |             
      Fatty Change                         |    2              2                             3  2                     |             
      Granuloma                            |                                                                          |             
      Hematopoietic Cell Proliferation     |                1                 2                                       |             
      Necrosis                             |                                                    3                     |             
      Bile Duct, Hyperplasia               |    1        1                 2     1     2  1  1     1  2               |             
      Hepatocyte, Hyperplasia              |    2                 3                                                   |             
      Portal, Inflammation, Chronic        |    1                       3              2              1               |             
                                            __________________________________________________________________________|             
   Mesentery                               | +  +           +              +                                          |             
      Fat, Inflammation, Acute             |                                                                          |             
      Fat, Necrosis                        |    3                          3                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Acinus, Atrophy                      |    2  2  3        3           2                          2               |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Inflammation, Acute                  |                                                 3                        |             
      Acinus, Atrophy                      |                                                                          |             
      Acinus, Hyperplasia                  |                                                                          |             
      Duct, Ectasia                        |                         3                                                |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Acute                  |    3                                                                     |             
      Inflammation, Chronic                |                                                 1                        |             
      Mineralization                       |                                                          2               |             
      Ulcer                                |    3                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Inflammation, Acute                  |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 7| 1| 6| 7| 7| 7| 6| 6| 7| 7| 7| 3| 6| 6| 6| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 7| 9| 4| 3| 3| 9| 4| 0| 3| 3| 3| 4| 1| 3| 3| 6| 1| 3| 9| 3| 6| 6| 6| 6| 6|             
                                           | 3| 4| 5| 0| 0| 5| 4| 1| 0| 0| 1| 0| 0| 0| 0| 7| 7| 0| 9| 0| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATD                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                                           3              2               |             
      Mucosa, Dilatation                   |       2  2  2     2  1     3  2  2  2     2  1  2  2  2  2               |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Peridontal Tissue, Hemorrhage        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Cardiomyopathy, Chronic              |       3  2  2     2  2  2  2  2  3  2  2  2     2  2  2  2               |             
      Hemorrhage                           |                2                                                         |             
      Coronary Artery, Mineralization      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Accessory Adrenal Cortical Nodule    |                                                          X               |             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                  X                                       |             
      Degeneration, Fatty                  | 2  2  2     2        1     2  2  1  1           1     2  2               |             
      Hematopoietic Cell Proliferation     |                2                                                         |             
      Hyperplasia                          |                                     2              1  1  2               |             
      Hypertrophy                          |                      2  2                                                |             
      Pigmentation                         |    1  2     1     1     1  2  1  1        1        1  1  1               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Hematopoietic Cell Proliferation     |                2                                                         |             
      Hyperplasia                          |       2     2                                                            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  M  M  M  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Pars Distalis, Cyst                  |             X                 X                                          |             
      Pars Distalis, Hyperplasia           |                               3                          2               |             
      Pars Distalis, Metaplasia, Osseous   |                      2                                                   |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      C-Cell, Hyperplasia                  |    1  1           2  2  1     2  1  1  1     1           3               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Abscess                              |                                  3                                       |             
      Inflammation, Chronic                |                                           2        1     1               |             
      Inflammation, Chronic Active         |                               2           3              2               |             
      Duct, Ectasia                        | 3                                   2                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 7| 1| 6| 7| 7| 7| 6| 6| 7| 7| 7| 3| 6| 6| 6| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 7| 9| 4| 3| 3| 9| 4| 0| 3| 3| 3| 4| 1| 3| 3| 6| 1| 3| 9| 3| 6| 6| 6| 6| 6|             
                                           | 3| 4| 5| 0| 0| 5| 4| 1| 0| 0| 1| 0| 0| 0| 0| 7| 7| 0| 9| 0| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATD                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Ectasia                              |          3                                   3                           |             
      Endometrium, Hyperplasia, Cystic     |                2                       1  2                              |             
                                            __________________________________________________________________________|             
   Vagina                                  |                +  +           +              +  +  +                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Inguinal, Hyperplasia, Lymphoid      |                2                                                         |             
      Mediastinal, Congestion              |                   4                    3                                 |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Hyperplasia, Reticulum  |                                                                          |             
          Cell                             |                                                                          |             
      Pancreatic, Congestion               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Hyperplasia, Lymphoid                |       2  2        2  2  2  2     3  2     2        3  2  3               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Congestion                           |                                                          2               |             
      Hyperplasia, Lymphoid                |       2  2                 3                                             |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Hematopoietic Cell Proliferation     | 2  2  2  3  2  1  2  3     2  2  3  2  2  2  2     2  2  2               |             
      Hyperplasia, Histiocytic, Lymphoid   |                                                                          |             
      Hyperplasia, Lymphoid                |          2                                   2                           |             
      Pigmentation                         |    3  3  2  2     3     3  3     3     2        4  3  3  2               |             
      Capsule, Fibrosis                    | 2                                                                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Acinus, Ectasia                      |    2  3  4  2     4  3  4  4  3  2  2  2  4     2  2     3               |             
      Acinus, Hyperplasia                  |                         3                                                |             
      Duct, Ectasia                        | 2                                      3                 2               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Cyst Epithelial Inclusion            |                   X                                                      |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 7| 1| 6| 7| 7| 7| 6| 6| 7| 7| 7| 3| 6| 6| 6| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 7| 9| 4| 3| 3| 9| 4| 0| 3| 3| 3| 4| 1| 3| 3| 6| 1| 3| 9| 3| 6| 6| 6| 6| 6|             
                                           | 3| 4| 5| 0| 0| 5| 4| 1| 0| 0| 1| 0| 0| 0| 0| 7| 7| 0| 9| 0| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATD                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Cranium, Fibrous Osteodystrophy      |                                                                          |             
      Cranium, Osteopetrosis               |                      4           4                       3               |             
      Femur, Fibrous Osteodystrophy        |                                                                          |             
      Femur, Osteopetrosis                 |                                                                          |             
      Rib, Hyperplasia                     |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Compression                          |    X  X           X  X     X     X     X  X     X  X                     |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                     1  1     2  1     2                  |             
      Alveolar Epithelium, Hyperplasia     |       2                                                                  |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |          2        1  2  2                 2  2  2  2  2  2               |             
      Arteriole, Mineralization            |    2  2  2        1  2  2     2  2     2  2           2                  |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Lumen, Hemorrhage                    |             1           2     2     1     2           2  2               |             
      Mucosa, Cyst                         |                                                                          |             
      Mucosa, Inflammation, Acute          |          3                                                               |             
      Nasolacrimal Duct, Hemorrhage        |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |       1           2                       2  1  2                        |             
      Olfactory Epithelium, Degeneration   | 2  2  2  2  2     2  2  2  2  2  2  2  2  2  2  2     2  2               |             
      Respiratory Epithelium, Degeneration | 2     1           1     2  2  2     2  1        2     2  2               |             
      Vomeronasal Organ, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                           +                              |             
      Cataract                             |                                           3                              |             
      Hemorrhage                           |                                                                          |             
      Synechia                             |                                                                          |             
      Retina, Degeneration                 |                                           4                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 7| 7| 1| 6| 7| 7| 7| 6| 6| 7| 7| 7| 3| 6| 6| 6| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 7| 9| 4| 3| 3| 9| 4| 0| 3| 3| 3| 4| 1| 3| 3| 6| 1| 3| 9| 3| 6| 6| 6| 6| 6|             
                                           | 3| 4| 5| 0| 0| 5| 4| 1| 0| 0| 1| 0| 0| 0| 0| 7| 7| 0| 9| 0| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    UNTREATD                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Nephropathy, Chronic                 | 2  2  3  3  2     3  2  2  2  2  3  1  3  3  1  3  3  4  3               |             
      Renal Tubule, Pigmentation           | 2  1  2  2  2     2  2  2  2  2  2  1  2  2     2  2  2  2               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 7| 7| 7| 6| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 7| 3| 3| 3| 4| 1| 3| 3| 3|                                            |            |
                                           | 1| 5| 0| 0| 0| 5| 0| 0| 0| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    UNTREATD                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Inflammation, Acute                  |                                                                          |      1  4.0|
      Parasite Metazoan                    |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Parasite Metazoan                    | X              X           X                                             |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Parasite Metazoan                    |                                                                          |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Angiectasis                          |                                                                          |      3  2.0|
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X                                             |     42     |
      Developmental Malformation           |                                                                          |      5     |
      Fatty Change                         | 2                                                                        |      6  2.0|
      Granuloma                            |                   2                                                      |      5  2.2|
      Hematopoietic Cell Proliferation     |          2  2                                                            |      4  1.8|
      Necrosis                             |                                                                          |      2  2.5|
      Bile Duct, Hyperplasia               | 1           1  2     2  1  2                                             |     23  1.4|
      Hepatocyte, Hyperplasia              |                                                                          |      2  2.5|
      Portal, Inflammation, Chronic        |          2  1  1     1  1  2                                             |     15  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +        +                                                            |  10        |
      Fat, Inflammation, Acute             |                                                                          |      1  4.0|
      Fat, Necrosis                        |    4        4                                                            |      7  3.4|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Acinus, Atrophy                      |    2  4              2  2  2                                             |     19  2.1|
      Acinus, Hyperplasia                  |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Inflammation, Acute                  |                                                                          |      2  2.5|
      Acinus, Atrophy                      |       2                                                                  |      1  2.0|
      Acinus, Hyperplasia                  |                            2                                             |      1  2.0|
      Duct, Ectasia                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 7| 7| 7| 6| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 7| 3| 3| 3| 4| 1| 3| 3| 3|                                            |            |
                                           | 1| 5| 0| 0| 0| 5| 0| 0| 0| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    UNTREATD                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      3  2.7|
      Mucosa, Dilatation                   | 2  2  2  2  2     2  2  1  2                                             |     41  1.9|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Peridontal Tissue, Hemorrhage        |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Cardiomyopathy, Chronic              | 1  1  2  2  2  2  3  2  2  1                                             |     44  1.9|
      Hemorrhage                           |                                                                          |      1  2.0|
      Coronary Artery, Mineralization      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1     |
      Angiectasis                          |          3                                                               |      1  3.0|
      Cyst                                 |                                                                          |      1     |
      Degeneration, Fatty                  | 3     2     1     2        2                                             |     26  1.9|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia                          |                         2                                                |      7  1.6|
      Hypertrophy                          |                                                                          |      4  1.8|
      Pigmentation                         |       2  1  1  1  1  1  2  1                                             |     28  1.2|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia                          |                         2                                                |      8  1.9|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +                                             |  41        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Pars Distalis, Cyst                  |                            X                                             |     10     |
      Pars Distalis, Hyperplasia           |                                                                          |      5  2.2|
      Pars Distalis, Metaplasia, Osseous   |                                                                          |      1  2.0|
      Pars Intermedia, Cyst                |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      C-Cell, Hyperplasia                  |       2  2  1     1  2  2  1                                             |     33  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 7| 7| 7| 6| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 7| 3| 3| 3| 4| 1| 3| 3| 3|                                            |            |
                                           | 1| 5| 0| 0| 0| 5| 0| 0| 0| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    UNTREATD                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  M  +  +  +                                             |  48        |
      Abscess                              |                                                                          |      1  3.0|
      Inflammation, Chronic                |       2        1                                                         |     10  1.5|
      Inflammation, Chronic Active         |                                                                          |      6  2.2|
      Duct, Ectasia                        |                                                                          |      5  2.8|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Periovarian Tissue, Cyst             |       X                                                                  |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Ectasia                              |          2                                                               |      3  2.7|
      Endometrium, Hyperplasia, Cystic     |             2     1        2                                             |      9  1.9|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   6        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Myelofibrosis                        |                            4                                             |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      1  2.0|
      Mediastinal, Congestion              |                                                                          |      3  3.3|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      4  2.3|
      Mediastinal, Hyperplasia, Reticulum  |                                                                          |            |
          Cell                             |                                                                          |      1  2.0|
      Pancreatic, Congestion               |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hyperplasia, Lymphoid                | 2     2     2  2  3  2  2                                                |     31  2.2|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Congestion                           |                   2                                                      |      2  2.0|
      Hyperplasia, Lymphoid                | 2           3           2                                                |     16  2.3|
      Hyperplasia, Reticulum Cell          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hematopoietic Cell Proliferation     | 2  2  2  2  3  2  2  2  2  2                                             |     44  2.2|
      Hyperplasia, Histiocytic, Lymphoid   |          2                                                               |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Pigmentation                         | 3  2  2  2  2  3     2  2                                                |     37  2.6|
      Capsule, Fibrosis                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  47        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 7| 7| 7| 6| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 7| 3| 3| 3| 4| 1| 3| 3| 3|                                            |            |
                                           | 1| 5| 0| 0| 0| 5| 0| 0| 0| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    UNTREATD                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                   X                                                      |      2     |
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                   3                                                      |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Acinus, Ectasia                      | 4  3  2  4  3  2  4  2  2                                                |     45  3.0|
      Acinus, Hyperplasia                  |          2                                                               |      4  2.8|
      Duct, Ectasia                        |    2           2        4                                                |     12  2.9|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Cyst Epithelial Inclusion            |                                                                          |      3     |
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
      Inflammation, Suppurative            |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Cranium, Fibrous Osteodystrophy      |                                                                          |      1  4.0|
      Cranium, Osteopetrosis               |                                                                          |      5  3.4|
      Femur, Fibrous Osteodystrophy        |                                                                          |      1  4.0|
      Femur, Osteopetrosis                 |                                                                          |      1  3.0|
      Rib, Hyperplasia                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Compression                          | X              X  X     X  X                                             |     19     |
      Hemorrhage                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Congestion                           |                                                                          |      1  2.0|
      Hemorrhage                           |       1     1              2                                             |     13  1.5|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |    1  2        2     2  1                                                |     28  1.7|
      Arteriole, Mineralization            |    2     2     2     2  2  2                                             |     27  1.9|
      Interstitium, Inflammation, Chronic  |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Lumen, Hemorrhage                    | 1        2  2        1                                                   |     22  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 7| 7| 7| 6| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 7| 3| 3| 3| 4| 1| 3| 3| 3|                                            |            |
                                           | 1| 5| 0| 0| 0| 5| 0| 0| 0| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    UNTREATD                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Mucosa, Cyst                         |                                                                          |      1     |
      Mucosa, Inflammation, Acute          |                                                                          |      3  3.0|
      Nasolacrimal Duct, Hemorrhage        |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           | 2           3              2                                             |     14  2.0|
      Olfactory Epithelium, Degeneration   | 2  2  2  2  2  2  2  2  2  1                                             |     46  2.0|
      Respiratory Epithelium, Degeneration |    2  3  2  2  1  2     2                                                |     30  1.7|
      Vomeronasal Organ, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +  +              +                                             |   6        |
      Cataract                             |          4  2              4                                             |      5  3.2|
      Hemorrhage                           |                            3                                             |      1  3.0|
      Synechia                             |                            4                                             |      1  4.0|
      Retina, Degeneration                 |          4  3              4                                             |      6  3.8|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Nephropathy, Chronic                 | 3  1  4  2  3  3  3  2  3  2                                             |     48  2.5|
      Renal Tubule, Pigmentation           | 1  1  2  2  2  2  2  2  2  1                                             |     47  1.9|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Mineralization                       |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 6| 6| 6| 6| 1| 3| 3| 3| 3|             
                                           | 0| 2| 0| 0| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| 1| 3| 3| 3| 3| 3| 2| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Parasite Metazoan                    |             X  X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Parasite Metazoan                    |       X           X        X              X                              |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Angiectasis                          |                                           2                              |             
      Basophilic Focus                     | X     X  X  X  X  X  X  X  X  X  X  X  X  X                 X  X  X  X  X|             
      Developmental Malformation           |             X  X        X        X        X                       X      |             
      Fatty Change                         |                                                             2            |             
      Granuloma                            |       2                          2     2                                 |             
      Hematopoietic Cell Proliferation     |                                                             2            |             
      Mineralization                       |                                                                          |             
      Bile Duct, Hyperplasia               | 1     2  1     1  2     1           1  1  2                    2     1   |             
      Portal, Inflammation, Chronic        |                1  2     1           1                          1        1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                      +   |             
      Fat, Necrosis                        |                                                                      3   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Acinus, Atrophy                      |          2     4  2  1  1  2     2     2                    2     1      |             
      Acinus, Hyperplasia                  |                                                                   2      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Duct, Hyperplasia                    | 2                                                                        |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                         2     2  2                                      1|             
      Mucosa, Dilatation                   |    2  2  2           2        2  1  2     2                 2  2  2  2  2|             
      Mucosa, Ulcer                        |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 6| 6| 6| 6| 1| 3| 3| 3| 3|             
                                           | 0| 2| 0| 0| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| 1| 3| 3| 3| 3| 3| 2| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cardiomyopathy, Chronic              | 1  1  2  2  1  2  2  3  2  2  2  1  1  3  3                    2  2  1  2|             
      Mineralization                       |                                                                          |             
      Coronary Artery, Mineralization      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Degeneration, Fatty                  | 1  3  2  2  1     2     2           2                          1     2   |             
      Hyperplasia                          | 2  2  1        2                 2        2                    2  2      |             
      Hypertrophy                          |                                           2                 1            |             
      Mineralization                       |                                                                          |             
      Pigmentation                         |       1  1  1  1     1     1  1  1  1  1  1                    1  1      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Hyperplasia                          |                            2                                         2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  M  +  +  M  +  +  M  +  +                 M  +  +  M  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 3                                                                        |             
      Pars Distalis, Cyst                  |    X              X  X     X  X           X                       X      |             
      Pars Distalis, Hyperplasia           | 3     1  2        1           2                                          |             
      Pars Intermedia, Cyst                |                                                                      X   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Ultimobranchial Cyst                 |                               X                                          |             
      C-Cell, Hyperplasia                  | 3  2  2     2     1           2  3     2                       2  1  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                |    3                          1     1                                    |             
      Inflammation, Chronic Active         |    4                                                                     |             
      Duct, Ectasia                        |                                                                          |             
      Duct, Hyperplasia                    |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Hyperplasia, Adenomatous             |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Ectasia                              |    2                                                                     |             
      Hemorrhage                           |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 6| 6| 6| 6| 1| 3| 3| 3| 3|             
                                           | 0| 2| 0| 0| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| 1| 3| 3| 3| 3| 3| 2| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |    3                    2        2                             3     2   |             
                                            __________________________________________________________________________|             
   Vagina                                  |                   +                                                      |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Hemorrhage                           |                               3                                          |             
      Myelofibrosis                        |                            4                                             |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Mediastinal, Congestion              |                                     2                                3  2|             
      Mediastinal, Hyperplasia, Lymphoid   |                                     2                                    |             
      Mediastinal, Pigmentation            |                                                                         2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                | 2           2  2     2  2  3  2     2  2                    2  2        2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                2           2  2     2  2                    3  3         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  1     2  2  3  2  2  2  1  2  2  2  2                    2  3  2  2  2|             
      Hyperplasia, Histiocytic, Lymphoid   |                                                                      4   |             
      Infarct                              |                                                                          |             
      Pigmentation                         |    3  2  3     2  2  2  2  3  2  3  2  3  2                 2  2  2     3|             
      Capsule, Inflammation, Chronic       |                                                                      2   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +                 +  +  +  +  +|             
      Congestion                           |                                                                      4   |             
      Cyst                                 |                X                                                         |             
      Hyperplasia, Lymphoid                |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Inflammation, Acute                  |                                                                   2      |             
      Acinus, Ectasia                      |       2  2     2  2  3  4           2  2                    4  4  3     2|             
      Acinus, Hyperplasia                  |                                                                   2      |             
      Duct, Ectasia                        |                               2  2                             4     2  2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Cranium, Inflammation, Chronic       |                                                                          |             
      Cranium, Osteopetrosis               |                                     3                                    |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 0| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 6| 6| 6| 6| 6| 1| 3| 3| 3| 3|             
                                           | 0| 2| 0| 0| 1| 1| 1| 1| 1| 1| 0| 1| 1| 1| 1| 3| 3| 3| 3| 3| 2| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Compression                          |                         X                                   X           X|             
      Hemorrhage                           |                                                                         2|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Congestion                           |                         2     2                                2        2|             
      Hemorrhage                           |    1           2     2     1        1                       1           1|             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 1  2  2  2  1     2        2     1  2  2                          2      |             
      Arteriole, Mineralization            |          2  2  2  2     2  2  2  2     2  2                 2  2     2  2|             
      Interstitium, Inflammation, Chronic  |                                        1                             1   |             
      Peribronchiolar, Inflammation, Acute |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Lumen, Hemorrhage                    |    2        1  2        2        2  2                                1  2|             
      Mucosa, Inflammation, Acute          |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                      2  2|             
      Olfactory Epithelium, Degeneration   | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2                 2  2  2  2   |             
      Respiratory Epithelium, Degeneration | 1  2  1        2     1        2  1  2  1  1                    2  2  3   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +     +  +  +                                                            |             
      Cataract                             | 3     4  4  2                                                            |             
      Hemorrhage                           |       4                                                                  |             
      Synechia                             |       3  3                                                               |             
      Retina, Degeneration                 | 4     4  4  4                                                            |             
      Sclera, Mineralization               |             2                                                            |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Cyst                                 |                      X        X     X                                    |             
      Mineralization                       |                                                                          |             
      Nephropathy, Chronic                 | 2  2  2  2  2  2  3  3  3  3  2  1  2  2  3                 2  3  3  3  1|             
      Pelvis, Inflammation, Acute          |                                                                          |             
      Pelvis, Necrosis                     |                                                                          |             
      Renal Tubule, Pigmentation           | 1  1  2  1  2  2  2  2  2  1  1  1  1  2  2                 1  2  2  2  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 6| 7| 7| 4| 4| 4| 4| 4| 3| 4| 6| 6| 7|             
                             DAY ON TEST   | 3| 3| 0| 0| 3| 6| 9| 9| 3| 3| 7| 1| 4| 1| 3| 6| 6| 6| 6| 6| 1| 3| 3| 4| 3|             
                                           | 5| 3| 0| 8| 1| 7| 4| 9| 1| 1| 1| 2| 0| 7| 1| 3| 3| 3| 3| 3| 6| 2| 4| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  I  +  +  +|             
      Mineralization                       |                                                                          |             
      Parasite Metazoan                    |          X                          X                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Parasite Metazoan                    |          X        X     X                                         X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  I  +  +  +|             
      Parasite Metazoan                    |          X              X                                            X   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | X  X  X  X  X  X     X  X  X  X     X  X  X                       X  X  X|             
      Developmental Malformation           |                         X  X     X                                       |             
      Fatty Change                         |    1  1                       2                             1            |             
      Granuloma                            |                         2  2              2                              |             
      Hematopoietic Cell Proliferation     |                                                                      2   |             
      Mineralization                       |                                                                          |             
      Bile Duct, Hyperplasia               |    2     1        3  1  1  1  1     1  2  1                             1|             
      Portal, Inflammation, Chronic        |    2                 1  3  1              1                    1        1|             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                                                  |             
      Fat, Necrosis                        |       4                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Acinus, Atrophy                      |          1        1  2  1              2                             2   |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Duct, Hyperplasia                    |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Inflammation, Chronic                |                   2                                                      |             
      Mineralization                       |    2                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |    2                    2                                   3            |             
      Mucosa, Dilatation                   | 2  2  2  2        1  2     2           2  1                          2  2|             
      Mucosa, Ulcer                        |                                                                3         |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 6| 7| 7| 4| 4| 4| 4| 4| 3| 4| 6| 6| 7|             
                             DAY ON TEST   | 3| 3| 0| 0| 3| 6| 9| 9| 3| 3| 7| 1| 4| 1| 3| 6| 6| 6| 6| 6| 1| 3| 3| 4| 3|             
                                           | 5| 3| 0| 8| 1| 7| 4| 9| 1| 1| 1| 2| 0| 7| 1| 3| 3| 3| 3| 3| 6| 2| 4| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cardiomyopathy, Chronic              | 1  1  2  2  3  2  1  2  1  3  1     1  1                    1     1  2  3|             
      Mineralization                       |                                                             2            |             
      Coronary Artery, Mineralization      |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Degeneration, Fatty                  |       1     2     2  1  3  1     3  1                                   2|             
      Hyperplasia                          |                                                                         2|             
      Hypertrophy                          |             2                             1                              |             
      Mineralization                       |                   2                                                      |             
      Pigmentation                         |    1  1     1     2  1  1  1  1  1     2  1                       1     1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Hyperplasia                          |                      2  2                                               2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Hyperplasia                          |                                           2                              |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +                 M  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                         X        X     X                       X     X  X|             
      Pars Distalis, Hyperplasia           |          2                             2                                 |             
      Pars Intermedia, Cyst                |                                        X                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Ultimobranchial Cyst                 |       X                                                                  |             
      C-Cell, Hyperplasia                  | 2  1  1  2  2        1  1  1           2  2                             2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Abscess                              |             4                                                            |             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                |       2                                2                             2   |             
      Inflammation, Chronic Active         |          2        3                                                      |             
      Duct, Ectasia                        |          3                                                               |             
      Duct, Hyperplasia                    |       2                                                                  |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Hyperplasia, Adenomatous             |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 6| 7| 7| 4| 4| 4| 4| 4| 3| 4| 6| 6| 7|             
                             DAY ON TEST   | 3| 3| 0| 0| 3| 6| 9| 9| 3| 3| 7| 1| 4| 1| 3| 6| 6| 6| 6| 6| 1| 3| 3| 4| 3|             
                                           | 5| 3| 0| 8| 1| 7| 4| 9| 1| 1| 1| 2| 0| 7| 1| 3| 3| 3| 3| 3| 6| 2| 4| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  |                         4                                                |             
      Endometrium, Hyperplasia, Cystic     | 2           2     2        3           2                                 |             
                                            __________________________________________________________________________|             
   Vagina                                  |                         +        +                          +  +         |             
      Inflammation, Acute                  |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                            3                                             |             
      Mediastinal, Pigmentation            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Congestion                           |                      2                                            3      |             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                | 2  2  2  2     2     3  2  2                                         2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 2                                                                    3  2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  2  2  2  2        2  2  2  2     2  2  2                          2  2|             
      Hyperplasia, Histiocytic, Lymphoid   |                                                                          |             
      Infarct                              |                   4                                                      |             
      Pigmentation                         | 2  3  2     2  3     3  3  2  3     2  2  2                 3  3  2  2  2|             
      Capsule, Inflammation, Chronic       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +                 +  I  +  +  +|             
      Congestion                           |                                                             2     2      |             
      Cyst                                 |                         X                 X                              |             
      Hyperplasia, Lymphoid                | 2  2  2              2                                                   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Acinus, Ectasia                      |    3  3  3  2  2  3  3  2  4  2     3  3  4                          2  2|             
      Acinus, Hyperplasia                  |                                                                          |             
      Duct, Ectasia                        | 2  3  4  3  3        3  3  4           2  3                       2     2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Cyst Epithelial Inclusion            |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Cranium, Inflammation, Chronic       |                                                                          |             
      Cranium, Osteopetrosis               |       3                                3                                 |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 6| 7| 7| 4| 4| 4| 4| 4| 3| 4| 6| 6| 7|             
                             DAY ON TEST   | 3| 3| 0| 0| 3| 6| 9| 9| 3| 3| 7| 1| 4| 1| 3| 6| 6| 6| 6| 6| 1| 3| 3| 4| 3|             
                                           | 5| 3| 0| 8| 1| 7| 4| 9| 1| 1| 1| 2| 0| 7| 1| 3| 3| 3| 3| 3| 6| 2| 4| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    5.0%                                   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Compression                          |    X  X              X        X                                          |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Congestion                           |             2  4                                            3  4  3      |             
      Hemorrhage                           | 1        1                    1                                          |             
      Alveolar Epithelium, Hyperplasia     |                                     2                                    |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 3  2  2  2                 2        2                                    |             
      Arteriole, Mineralization            | 2     2        2  2  2  2  2  2     2  2  2                             1|             
      Interstitium, Inflammation, Chronic  |                                                                          |             
      Peribronchiolar, Inflammation, Acute |                                                                4         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Lumen, Hemorrhage                    | 2  2  1  2  2           1  1  1     2                       2           1|             
      Mucosa, Inflammation, Acute          |                                                             1  1         |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |    2  2  2  1                 1     3                                    |             
      Olfactory Epithelium, Degeneration   | 1  2  2  2  2  2  2  2  2  2  2  2  2  2  2                       2     2|             
      Respiratory Epithelium, Degeneration |          1     3  1  2  2           1                             1      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +     +                 +                             +|             
      Cataract                             |                   4     4                 4                             4|             
      Hemorrhage                           |                         4                                                |             
      Synechia                             |                         4                                                |             
      Retina, Degeneration                 |                   4     4                 4                             4|             
      Sclera, Mineralization               |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Mineralization                       |                                                             3            |             
      Nephropathy, Chronic                 | 2  2  2  2  2  1  1  2  2  2  2     2  2  3                    1  1  2  3|             
      Pelvis, Inflammation, Acute          |             2                                               4            |             
      Pelvis, Necrosis                     |                                                             4            |             
      Renal Tubule, Pigmentation           |    2  2  2  2  1     2  2  2  1  2  1  2  2                          1  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Hemorrhage                           |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 6| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 1| 3| 3| 3| 2| 9| 9| 1| 3|                                            |            |
                                           | 8| 9| 1| 1| 1| 3| 4| 8| 6| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    5.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Mineralization                       |                      2                                                   |      1  2.0|
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Mineralization                       |                      2                                                   |      1  2.0|
      Parasite Metazoan                    |       X                                                                  |      7     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Parasite Metazoan                    |                                                                          |      7     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     |    X  X  X  X  X     X  X  X                                             |     43     |
      Developmental Malformation           |                         X                                                |     10     |
      Fatty Change                         |                   3  2  1                                                |      8  1.6|
      Granuloma                            |       2     2                                                            |      8  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
      Mineralization                       |          2                                                               |      1  2.0|
      Bile Duct, Hyperplasia               | 1  1     1     1     1     2                                             |     28  1.3|
      Portal, Inflammation, Chronic        |             2  1     1                                                   |     16  1.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                                                      |   3        |
      Fat, Necrosis                        |                   3                                                      |      3  3.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Acinus, Atrophy                      |          1     2  2  1                                                   |     20  1.7|
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Duct, Hyperplasia                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Inflammation, Chronic                |                   3                                                      |      2  2.5|
      Mineralization                       |       4                                                                  |      2  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Inflammation, Chronic Active         |                   3                                                      |      1  3.0|
      Mineralization                       |       4                                                                  |      8  2.3|
      Mucosa, Dilatation                   |       2  2  2  2     2  2  2                                             |     31  1.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 6| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 1| 3| 3| 3| 2| 9| 9| 1| 3|                                            |            |
                                           | 8| 9| 1| 1| 1| 3| 4| 8| 6| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    5.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mucosa, Ulcer                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Cardiomyopathy, Chronic              |    1  2  2  2  2  2  2  2  1                                             |     45  1.8|
      Mineralization                       |                                                                          |      1  2.0|
      Coronary Artery, Mineralization      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Degeneration, Fatty                  |                2  2  3     2                                             |     23  1.9|
      Hyperplasia                          |                                                                          |      9  1.9|
      Hypertrophy                          |                                                                          |      4  1.5|
      Mineralization                       |                                                                          |      1  2.0|
      Pigmentation                         |       1  1  1     1  1     1                                             |     32  1.1|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hyperplasia                          | 2                                                                        |      6  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +                                             |  41        |
      Hyperplasia                          |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Pars Distalis, Angiectasis           |                                                                          |      1  3.0|
      Pars Distalis, Cyst                  |                X        X                                                |     15     |
      Pars Distalis, Hyperplasia           |                                                                          |      7  1.9|
      Pars Intermedia, Cyst                |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Ultimobranchial Cyst                 |                                                                          |      2     |
      C-Cell, Hyperplasia                  |    1  2  2  1  1  2     2  2                                             |     30  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Abscess                              |                                                                          |      1  4.0|
      Cyst                                 |          X                                                               |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 6| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 1| 3| 3| 3| 2| 9| 9| 1| 3|                                            |            |
                                           | 8| 9| 1| 1| 1| 3| 4| 8| 6| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    5.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |       2     1     1                                                      |      9  1.7|
      Inflammation, Chronic Active         |                                                                          |      3  3.0|
      Duct, Ectasia                        |                                                                          |      1  3.0|
      Duct, Hyperplasia                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hyperplasia, Adenomatous             |                            2                                             |      1  2.0|
      Follicle, Cyst                       |             X                                                            |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Ectasia                              |          2                                                               |      2  2.0|
      Hemorrhage                           |          4     4                                                         |      3  3.7|
      Inflammation, Acute                  |                                                                          |      1  4.0|
      Endometrium, Hyperplasia, Cystic     |       2        2           2                                             |     13  2.2|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   5        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Myelofibrosis                        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Mediastinal, Congestion              |    2  3                                                                  |      5  2.4|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      2  2.5|
      Mediastinal, Pigmentation            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Congestion                           |                                                                          |      2  2.5|
      Cyst                                 |    X                                                                     |      1     |
      Hyperplasia, Lymphoid                |    2     2     3           3                                             |     25  2.2|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hyperplasia, Lymphoid                |             2           2                                                |     12  2.3|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hematopoietic Cell Proliferation     |    2  2  2  2  3  2     2                                                |     39  2.0|
      Hyperplasia, Histiocytic, Lymphoid   |                                                                          |      1  4.0|
      Infarct                              |                                                                          |      1  4.0|
      Pigmentation                         |    3  2  3  3     2  4  2  2                                             |     42  2.4|
      Capsule, Inflammation, Chronic       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  47        |
      Congestion                           |                                                                          |      3  2.7|
      Cyst                                 |                      X  X                                                |      5     |
      Hyperplasia, Lymphoid                |                                                                          |      5  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 6| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 1| 3| 3| 3| 2| 9| 9| 1| 3|                                            |            |
                                           | 8| 9| 1| 1| 1| 3| 4| 8| 6| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    5.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Acinus, Ectasia                      |    4  3  4  3  3  3     3  2                                             |     35  2.8|
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
      Duct, Ectasia                        | 2           4     3  3                                                   |     21  2.8|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Cranium, Inflammation, Chronic       |             3                                                            |      1  3.0|
      Cranium, Osteopetrosis               |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                      +                                                   |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Compression                          |    X                                                                     |      8     |
      Hemorrhage                           | 2                                                                        |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Congestion                           |                                                                          |      9  2.7|
      Hemorrhage                           |                         1                                                |     11  1.2|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |       2        2        2                                                |     20  1.9|
      Arteriole, Mineralization            | 2  2  2  2  2  2  2        2                                             |     34  2.0|
      Interstitium, Inflammation, Chronic  |                                                                          |      2  1.0|
      Peribronchiolar, Inflammation, Acute |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Lumen, Hemorrhage                    |       2                 2  1                                             |     22  1.6|
      Mucosa, Inflammation, Acute          |             2                                                            |      3  1.3|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |    2                                                                     |      9  1.9|
      Olfactory Epithelium, Degeneration   | 2     2  2  2  2  2     2  2                                             |     44  2.0|
      Respiratory Epithelium, Degeneration |       1  1  2  2  2  1  2  1                                             |     28  1.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 6| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 1| 3| 3| 3| 2| 9| 9| 1| 3|                                            |            |
                                           | 8| 9| 1| 1| 1| 3| 4| 8| 6| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    5.0%                                   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                +  +                                                      |  10        |
      Cataract                             |                4  4                                                      |     10  3.7|
      Hemorrhage                           |                4  2                                                      |      4  3.5|
      Synechia                             |                                                                          |      3  3.3|
      Retina, Degeneration                 |                4  4                                                      |     10  4.0|
      Sclera, Mineralization               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                +                                                         |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Cyst                                 |                                                                          |      3     |
      Mineralization                       |                                                                          |      1  3.0|
      Nephropathy, Chronic                 | 2  2  1  1  2  1  2  1  1  2                                             |     48  2.0|
      Pelvis, Inflammation, Acute          |                                                                          |      2  3.0|
      Pelvis, Necrosis                     |                                                                          |      1  4.0|
      Renal Tubule, Pigmentation           | 1  1  2  2  2  1  2  2  2  2                                             |     45  1.7|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hemorrhage                           |                      2                                                   |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 3| 3| 0| 2| 3| 3| 3| 6| 6| 6| 6| 6| 6| 8| 1| 3| 3| 1| 2| 0| 1| 3|             
                                           | 0| 8| 0| 1| 1| 0| 4| 1| 4| 4| 3| 3| 3| 3| 3| 7| 7| 7| 4| 4| 9| 3| 2| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             X           X                             X           X      |             
      Ulcer                                |                                                       2                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |          X                                      X                        |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                 A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                 A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                 A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                 A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X  X  X  X  X  X  X  X  X                       X  X  X        X     X|             
      Developmental Malformation           |    X                                                                     |             
      Fatty Change                         | 2                                                           2  2         |             
      Granuloma                            |                   2  2  2                             2  2        2     2|             
      Hematopoietic Cell Proliferation     |       1        2  2                                                     2|             
      Bile Duct, Hyperplasia               | 1        1  1  2        1                       4     1     2  1  1      |             
      Hepatocyte, Hyperplasia              |                                                                          |             
      Portal, Inflammation, Chronic        |       1        2  2  1  1                             1  2        2     1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  M  +  +  +  +  +                 A  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |    2              2     3  2                       2           3        2|             
      Artery, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Chronic                |                                                                2         |             
      Mineralization                       |                                                             2            |             
      Ulcer                                |                                                                      4   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 2                                                           2            |             
      Mucosa, Dilatation                   | 2  2     2  2  2  2  2     2                       2  2  2  2  2  2  2   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 2  2     3  2  3  2  3  3  3                 2  2     2  2  1     2  2  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 3| 3| 0| 2| 3| 3| 3| 6| 6| 6| 6| 6| 6| 8| 1| 3| 3| 1| 2| 0| 1| 3|             
                                           | 0| 8| 0| 1| 1| 0| 4| 1| 4| 4| 3| 3| 3| 3| 3| 7| 7| 7| 4| 4| 9| 3| 2| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Degeneration, Fatty                  |    2        2              1                    2  2  2              2   |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          | 2  2  2     2                                                     1      |             
      Pigmentation                         | 2  1        1  1  1                             2     2  1  1  1        2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   2                                         2            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  M  +  +  +  +  +                 A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  M                 +  +  M  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                            4                                             |             
      Pars Distalis, Cyst                  |       X  X     X     X                                X                  |             
      Pars Distalis, Hyperplasia           |                      2     2                                      2      |             
      Pars Intermedia, Cyst                |                                                       X                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |    X                                                                     |             
      C-Cell, Hyperplasia                  | 1  2     2     1  1  1     1                    2  2  2  1           1  2|             
      Follicle, Ectasia                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  M  +  +|             
      Abscess                              |                                                                          |             
      Inflammation, Chronic                |    3              2  1                             1                    2|             
      Inflammation, Chronic Active         |                   2                                         2            |             
      Duct, Ectasia                        |                                                                3         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Cervix, Epithelium, Cyst             |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |    2                                               2                     |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                              +                 +     +   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +                                                                        |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Reticulum Cell          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 3| 3| 0| 2| 3| 3| 3| 6| 6| 6| 6| 6| 6| 8| 1| 3| 3| 1| 2| 0| 1| 3|             
                                           | 0| 8| 0| 1| 1| 0| 4| 1| 4| 4| 3| 3| 3| 3| 3| 7| 7| 7| 4| 4| 9| 3| 2| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Congestion              |    2              2  3                                2  1        2      |             
      Mediastinal, Hyperplasia, Lymphoid   |             2                                                            |             
      Mediastinal, Hyperplasia, Reticulum  |                                                                          |             
          Cell                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 2  2        2  2     2     2                       3  2  3        2      |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                          2               |             
      Hyperplasia, Lymphoid                |    2           2                                      3                 2|             
      Hyperplasia, Reticulum Cell          |                      2                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     | 3  2  3  2  2  3     2  2  2                       3  2           2      |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Necrosis                             |                                                                      2   |             
      Pigmentation                         |    2     2  3        2  2  2                 2     2  2  3        2     3|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  M  M  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                X         |             
      Hyperplasia, Lymphoid                |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Acinus, Ectasia                      |       3  3  3  2  2  3  2  2                 2     2  2  3  3  2     3   |             
      Acinus, Hyperplasia                  |                   3     2                                                |             
      Duct, Ectasia                        |          3                                      2     2           2     1|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Alopecia                             |                                                                          |             
      Cyst Epithelial Inclusion            |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Cranium, Osteopetrosis               |                                                          3     3         |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                      +   |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Compression                          |          2        3                                         2  3        3|             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 4| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 0| 3| 3| 0| 2| 3| 3| 3| 6| 6| 6| 6| 6| 6| 8| 1| 3| 3| 1| 2| 0| 1| 3|             
                                           | 0| 8| 0| 1| 1| 0| 4| 1| 4| 4| 3| 3| 3| 3| 3| 7| 7| 7| 4| 4| 9| 3| 2| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                                              3                           |             
      Hemorrhage                           |                         2                             1  2               |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                1                                                         |             
      Arteriole, Mineralization            | 2  1           2     2  1  2                    2     1     2  2  2     2|             
      Interstitium, Inflammation, Chronic  |                            1                                             |             
      Mediastinum, Inflammation, Acute     |                                                                          |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic Active                   |                                                    3                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Lumen, Hemorrhage                    |                   2     2                             2           2     2|             
      Lumen, Inflammation, Acute           |                                                                          |             
      Mucosa, Inflammation, Acute          |                                              2     3  2                  |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |    2                                                           2        2|             
      Olfactory Epithelium, Degeneration   | 2  2  2  2  2  2     2  2  2                    2     2  2  2  2  2  2  2|             
      Respiratory Epithelium, Degeneration | 1     2  1  2  1           2                    1              2     1  2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +           +  +                          +           +      |             
      Cataract                             |                         3  4                          4           2      |             
      Hemorrhage                           |                         3  3                                             |             
      Retina, Degeneration                 |             4           4  4                          4           4      |             
      Sclera, Mineralization               |                                                                   2      |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Inflammation, Acute                  |                                              4                           |             
      Mineralization                       |                                                                          |             
      Nephropathy, Chronic                 | 2  2     4  2  2  3  2  2  2                    2  3  2  2  2  3  2  2  1|             
      Pelvis, Inflammation, Chronic        |                                                                          |             
      Renal Tubule, Pigmentation           | 2  2  2  2  2  2  2  2  2  2                 1  2  2  2  2  3  2  2  2  2|             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                              X                           |             
      Inflammation, Chronic                |                                              4                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 2| 4| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 3| 6| 4| 3| 3| 3| 7| 6| 6| 3| 3| 3| 4| 3| 3| 3| 1| 3| 3| 3| 3|             
                                           | 2| 4| 4| 4| 4| 6| 0| 4| 4| 4| 3| 7| 1| 7| 4| 2| 0| 4| 4| 4| 0| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    2.5%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                 X                        |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                     X                          X         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    X  X           X                                         X     X  X   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X              X  X     X     X  X  X  X  X  X|             
      Developmental Malformation           |                                                             X            |             
      Fatty Change                         |       1                             2                 2                  |             
      Granuloma                            |    2                                               2           2     2   |             
      Hematopoietic Cell Proliferation     |                                                             1     2  2   |             
      Bile Duct, Hyperplasia               | 1     1     1  1     1     3        1              1     1     1  1  1  1|             
      Hepatocyte, Hyperplasia              |          3                                                               |             
      Portal, Inflammation, Chronic        | 2  1  1     1              2        1                 1        1     2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                             +  +           +                  |             
      Fat, Necrosis                        |          4                             4  4           3                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |          2                                2        2     2     2     2   |             
      Artery, Inflammation, Chronic        |             2                                                            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                               2                                          |             
      Hyperkeratosis                       |    3                                                                     |             
      Hyperplasia, Squamous                |                2                                                         |             
      Inflammation, Chronic                |                2                                                         |             
      Mineralization                       |                                                 1                        |             
      Ulcer                                |                                  3  4                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |          2                                         2           2         |             
      Mucosa, Dilatation                   | 2  2  2  2  2  2  2  2  2  2           2  2  2  1  2  2  1  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Tooth                                   |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 2  2  2  2  1     1  3  2              2  1  1     1  2  1     2  2  2  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 2| 4| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 3| 6| 4| 3| 3| 3| 7| 6| 6| 3| 3| 3| 4| 3| 3| 3| 1| 3| 3| 3| 3|             
                                           | 2| 4| 4| 4| 4| 6| 0| 4| 4| 4| 3| 7| 1| 7| 4| 2| 0| 4| 4| 4| 0| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    2.5%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                            3                             3  2            |             
      Degeneration, Fatty                  |    2  1  1  2        2              2     2        2  2        1  2      |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          | 1                       2        2                 2     2  2  2  2  2   |             
      Pigmentation                         | 1  1  1  1  1     1  1     1        1     1     1  1  2  1     1  1     1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         2                                               2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                         3     2                    3                     |             
      Pars Distalis, Cyst                  | X           X                             X  X                       X  X|             
      Pars Distalis, Hyperplasia           | 2        2                          2     2  1     2     2     2         |             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |       2     2        1              1           2  2     1               |             
      Follicle, Ectasia                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                           3                              |             
      Inflammation, Chronic                |       1           2                    2  3     2     1     2            |             
      Inflammation, Chronic Active         |                                                                          |             
      Duct, Ectasia                        |                         3                                                |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              | 2                                      2     2                           |             
      Cervix, Epithelium, Cyst             |                                                    X                     |             
      Endometrium, Hyperplasia, Cystic     |                2  2        2                    2  2     1              2|             
                                            __________________________________________________________________________|             
   Vagina                                  |       +        +              +        +  +     +                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Reticulum Cell          |             2                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 2| 4| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 3| 6| 4| 3| 3| 3| 7| 6| 6| 3| 3| 3| 4| 3| 3| 3| 1| 3| 3| 3| 3|             
                                           | 2| 4| 4| 4| 4| 6| 0| 4| 4| 4| 3| 7| 1| 7| 4| 2| 0| 4| 4| 4| 0| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    2.5%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Congestion              |             2                                2              2            |             
      Mediastinal, Hyperplasia, Lymphoid   |                                           2           2                  |             
      Mediastinal, Hyperplasia, Reticulum  |                                                                          |             
          Cell                             |          2                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |    2        2     2     2                 2     3  2           2  2  2   |             
      Pigmentation                         |                2                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |    3              2     2                                3           2  2|             
      Hyperplasia, Reticulum Cell          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                        3                                 |             
      Hematopoietic Cell Proliferation     | 3  2  2  2  2  2  2  2                 2     3        2  2  2  2  2  2  2|             
      Hyperplasia, Lymphoid                |                                                                      2   |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |    2  2  2  2  3  2  2  3  2  2  2        2        3  3  2  2  2     2  2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                                           X  X                           |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Ectasia                      |    2  2  3        2     2              2              2        2     3  2|             
      Acinus, Hyperplasia                  |                   3                                                      |             
      Duct, Ectasia                        |       2     2           2           2           2  2  2     2  2     3  2|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alopecia                             |                            2                                             |             
      Cyst Epithelial Inclusion            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Osteopetrosis               |                                                 2  3                     |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |    +                                            +                        |             
      Inflammation, Chronic                |    4                                                                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |    3              2                    3        2     1     2            |             
      Hydrocephalus                        |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 6| 7| 7| 7| 2| 4| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 3| 3| 3| 6| 4| 3| 3| 3| 7| 6| 6| 3| 3| 3| 4| 3| 3| 3| 1| 3| 3| 3| 3|             
                                           | 2| 4| 4| 4| 4| 6| 0| 4| 4| 4| 3| 7| 1| 7| 4| 2| 0| 4| 4| 4| 0| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    2.5%                                   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Congestion                           |                                                             2            |             
      Hemorrhage                           |                                                    1        2            |             
      Alveolar Epithelium, Hyperplasia     |          3                                                               |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |       2  2  1        1                    1     3     1     1  1     1  1|             
      Arteriole, Mineralization            |    2     2  1        2     1           2     2  2  2                 2  2|             
      Interstitium, Inflammation, Chronic  |                                                          2               |             
      Mediastinum, Inflammation, Acute     |                                  3                                       |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic Active                   |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Hemorrhage                    | 1                    2  2  1  2                 2  2           2  2  2   |             
      Lumen, Inflammation, Acute           |                                     1                                    |             
      Mucosa, Inflammation, Acute          |                               3                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |             2        2     2           1     2                    2      |             
      Olfactory Epithelium, Degeneration   | 2  2  2  2  2  2  2  1  2  2        2  2  2  2  2  2  1  2  2  2  2  2  2|             
      Respiratory Epithelium, Degeneration |       1  1  1     1  2                    1  1           1        1     2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +           +                                         +               |             
      Cataract                             | 4  4           2                                         3               |             
      Hemorrhage                           |                                                                          |             
      Retina, Degeneration                 | 4  4           4                                         4               |             
      Sclera, Mineralization               |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |                                  2                                       |             
      Nephropathy, Chronic                 | 2  3  2  1  3     3  2  3  1     1  2  2  1     2  2  2  2     4  1  2  3|             
      Pelvis, Inflammation, Chronic        |                                                                          |             
      Renal Tubule, Pigmentation           | 2  2  2  2  2  2  2  2  2  2        2  2  2  2  3  2  2  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 3| 6| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 2| 4| 1| 3| 3|                                            |            |
                                           | 3| 3| 3| 3| 3| 3| 6| 6| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                M  +  +  +  +                                             |  48        |
      Parasite Metazoan                    |                                                                          |      5     |
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                +  +  +  +  +                                             |  49        |
      Parasite Metazoan                    |                X           X                                             |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                +  +  +  +  +                                             |  50        |
      Parasite Metazoan                    |                   X  X     X                                             |     11     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                +  +  +  +  +                                             |  50        |
      Basophilic Focus                     |                   X  X  X  X                                             |     37     |
      Developmental Malformation           |                X     X                                                   |      4     |
      Fatty Change                         |                                                                          |      6  1.8|
      Granuloma                            |                                                                          |     11  2.0|
      Hematopoietic Cell Proliferation     |                   1  2  2                                                |     10  1.7|
      Bile Duct, Hyperplasia               |                            1                                             |     24  1.3|
      Hepatocyte, Hyperplasia              |                                                                          |      1  3.0|
      Portal, Inflammation, Chronic        |                      2  2  2                                             |     21  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Fat, Necrosis                        |                                                                          |      4  3.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                +  +  +  +  +                                             |  47        |
      Acinus, Atrophy                      |                   1        2                                             |     15  2.1|
      Artery, Inflammation, Chronic        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                +  +  +  +  +                                             |  50        |
      Edema                                |                                                                          |      1  2.0|
      Hyperkeratosis                       |                                                                          |      1  3.0|
      Hyperplasia, Squamous                |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Mineralization                       |                         2                                                |      3  1.7|
      Ulcer                                |                                                                          |      3  3.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                +  +  +  +  +                                             |  50        |
      Mineralization                       |                         2                                                |      6  2.0|
      Mucosa, Dilatation                   |                   2     2                                                |     39  1.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 3| 6| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 2| 4| 1| 3| 3|                                            |            |
                                           | 3| 3| 3| 3| 3| 3| 6| 6| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                +  +  +  +  +                                             |  50        |
      Cardiomyopathy, Chronic              |                2  2  2  1  2                                             |     40  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                +  +  +  +  +                                             |  50        |
      Angiectasis                          |                            3                                             |      4  2.8|
      Degeneration, Fatty                  |                   2  2  2  2                                             |     22  1.8|
      Hemorrhage                           |                3                                                         |      1  3.0|
      Hyperplasia                          |                   2  2                                                   |     16  1.9|
      Pigmentation                         |                   1  1     2                                             |     31  1.2|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                +  +  +  +  +                                             |  50        |
      Hyperplasia                          |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                +  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                M  M  +  +  +                                             |  41        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                +  +  +  +  +                                             |  50        |
      Pars Distalis, Angiectasis           |                                                                          |      4  3.0|
      Pars Distalis, Cyst                  |                   X  X                                                   |     13     |
      Pars Distalis, Hyperplasia           |                   1  2                                                   |     13  1.8|
      Pars Intermedia, Cyst                |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                +  +  +  +  +                                             |  50        |
      Ultimobranchial Cyst                 |                                                                          |      1     |
      C-Cell, Hyperplasia                  |                      2  2  2                                             |     23  1.6|
      Follicle, Ectasia                    |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                +  +  +  +  +                                             |  49        |
      Abscess                              |                                                                          |      1  3.0|
      Inflammation, Chronic                |                      3     2                                             |     14  1.9|
      Inflammation, Chronic Active         |                      4     2                                             |      4  2.5|
      Duct, Ectasia                        |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   |                +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Uterus                                  |                +  +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 3| 6| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 2| 4| 1| 3| 3|                                            |            |
                                           | 3| 3| 3| 3| 3| 3| 6| 6| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Ectasia                              |                                                                          |      3  2.0|
      Cervix, Epithelium, Cyst             |                                                                          |      1     |
      Endometrium, Hyperplasia, Cystic     |                      1                                                   |     10  1.8|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   9        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                +  +  +  +  +                                             |  50        |
      Hyperplasia, Reticulum Cell          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +  +  +  +  +                                             |  50        |
      Mediastinal, Congestion              |                      2  2                                                |     11  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      3  2.0|
      Mediastinal, Hyperplasia, Reticulum  |                                                                          |            |
          Cell                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                +  +  +  +  +                                             |  50        |
      Hyperplasia, Lymphoid                |                   2  2     2                                             |     23  2.1|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                +  +  +  +  +                                             |  50        |
      Congestion                           |                            2                                             |      2  2.0|
      Hyperplasia, Lymphoid                |                         2                                                |     11  2.3|
      Hyperplasia, Reticulum Cell          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                +  +  +  +  +                                             |  50        |
      Fibrosis                             |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                2  2  3  3  2                                             |     34  2.2|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
      Pigmentation                         |                2  2     2  2                                             |     35  2.2|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                +  +  +  M  +                                             |  46        |
      Congestion                           |                4                                                         |      1  4.0|
      Cyst                                 |                            X                                             |      4     |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                +  +  +  +  +                                             |  48        |
      Acinus, Ectasia                      |                      2  3  2                                             |     28  2.4|
      Acinus, Hyperplasia                  |                                                                          |      3  2.7|
      Duct, Ectasia                        |                   2  2  3  2                                             |     20  2.1|
                                            __________________________________________________________________________|____________|
   Skin                                    |                +  +  +  +  +                                             |  50        |
      Alopecia                             |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 3| 6| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 2| 4| 1| 3| 3|                                            |            |
                                           | 3| 3| 3| 3| 3| 3| 6| 6| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                +  +  +  +  +                                             |  50        |
      Cranium, Osteopetrosis               |                      3                                                   |      5  2.8|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   3        |
      Inflammation, Chronic                |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                +  +  +  +  +                                             |  50        |
      Compression                          |                         2  2                                             |     13  2.3|
      Hydrocephalus                        |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                +  +  +  +  +                                             |  50        |
      Congestion                           |                3                                                         |      3  2.7|
      Hemorrhage                           |                                                                          |      5  1.6|
      Alveolar Epithelium, Hyperplasia     |                   2        2                                             |      3  2.3|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                      1     1                                             |     14  1.3|
      Arteriole, Mineralization            |                      1  2                                                |     25  1.8|
      Interstitium, Inflammation, Chronic  |                                                                          |      2  1.5|
      Mediastinum, Inflammation, Acute     |                                                                          |      1  3.0|
      Peribronchiolar, Inflammation,       |                                                                          |            |
          Chronic Active                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                +  +  +  +  +                                             |  50        |
      Lumen, Hemorrhage                    |                         2  2                                             |     17  1.9|
      Lumen, Inflammation, Acute           |                                                                          |      1  1.0|
      Mucosa, Inflammation, Acute          |                                                                          |      4  2.5|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      9  1.9|
      Olfactory Epithelium, Degeneration   |                   2  2  2  2                                             |     44  2.0|
      Respiratory Epithelium, Degeneration |                      1  1                                                |     22  1.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   9        |
      Cataract                             |                                                                          |      8  3.3|
      Hemorrhage                           |                                                                          |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 3| 6| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 2| 4| 1| 3| 3|                                            |            |
                                           | 3| 3| 3| 3| 3| 3| 6| 6| 4| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    2.5%                                   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Retina, Degeneration                 |                                                                          |      9  4.0|
      Sclera, Mineralization               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                +  +  +  +  +                                             |  50        |
      Congestion                           |                2                                                         |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  4.0|
      Mineralization                       |                                                                          |      1  2.0|
      Nephropathy, Chronic                 |                   2  1  2  2                                             |     43  2.1|
      Pelvis, Inflammation, Chronic        |                   3                                                      |      1  3.0|
      Renal Tubule, Pigmentation           |                   2  2  2  2                                             |     47  2.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                +                                                         |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                +  +  +  +  +                                             |  50        |
      Calculus Gross Observation           |                   X                                                      |      2     |
      Inflammation, Chronic                |                   4                                                      |      2  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 8| 2| 2| 2| 2| 9| 0| 2| 2| 2| 6| 6| 2| 2| 2| 6| 2| 2| 2| 2| 6| 6| 6| 6| 6|             
                                           | 5| 9| 9| 9| 9| 8| 1| 9| 9| 9| 1| 2| 3| 9| 9| 1| 9| 9| 9| 9| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Parasite Metazoan                    |             X              X                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Parasite Metazoan                    |    X        X                                   X                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Angiectasis                          |                                  3                                       |             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X           X  X     X  X  X  X               |             
      Congestion                           |                                                                          |             
      Developmental Malformation           |          X  X                    X                                       |             
      Focal Cellular Change                |                                                                          |             
      Necrosis                             |                            2              1                              |             
      Vacuolization Cytoplasmic            |                               2     1                                    |             
      Bile Duct, Hyperplasia               |    2  2  2  2  2  2  2  2  3  2  4  2  2  2  2  2  2  2  3               |             
      Portal, Inflammation, Chronic        | 2  2  2  1  2  2  1  2  2  2  1  3  1  2  2  2  2     2  2               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +  +                                                      |             
      Fat, Necrosis                        |                3  3                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Acinus, Atrophy                      |       3  1  1     2  2        2           2  1  2        1               |             
      Acinus, Hyperplasia                  |                                                                          |             
      Duct, Ectasia                        |                                     2                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Infiltration Cellular, Lymphocyte    | 2                       2  2                             2               |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Edema                                |                                                                          |             
      Hyperkeratosis                       |                                     3                                    |             
      Inflammation, Acute                  |                                  2                                       |             
      Inflammation, Chronic Active         |                                     3                                    |             
      Ulcer                                | 3                                                                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Mineralization                       |                                     3                                    |             
      Mucosa, Dilatation                   |    1  2  1  2  1  1  1     2           1  2  2  1  2     2               |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 8| 2| 2| 2| 2| 9| 0| 2| 2| 2| 6| 6| 2| 2| 2| 6| 2| 2| 2| 2| 6| 6| 6| 6| 6|             
                                           | 5| 9| 9| 9| 9| 8| 1| 9| 9| 9| 1| 2| 3| 9| 9| 1| 9| 9| 9| 9| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |          +                                            +                  |             
      Artery, Inflammation, Chronic        |          2                                            4                  |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Cardiomyopathy, Chronic              | 2  2  2  2  2  2  1  3  2  2  2  2  1  2  2  2  3  3  3  2               |             
      Mineralization                       |    2           2                                                         |             
      Pigmentation, Hemosiderin            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +               |             
      Accessory Adrenal Cortical Nodule    |                                        X                                 |             
      Degeneration, Fatty                  | 1  2     2  2  2  1  2  2     2  2  3  2     2  2     2                  |             
      Hyperplasia                          |       2                    2           2              2                  |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Necrosis                             |                                  2                                       |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Hyperplasia                          | 2                    1  1           2              2                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  +  +  +  +  M  +  +  M  +  M  +  +  +  +  +  +  M               |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Pars Distalis, Cyst                  |          X                                X              X               |             
      Pars Distalis, Hemorrhage            |                                        3                                 |             
      Pars Distalis, Hyperplasia           |       2           2              3     2                 2               |             
      Pars Distalis, Infarct               |                4                                                         |             
      Pars Distalis, Infiltration Cellular,|                                                                          |             
           Lymphocyte                      |                                                       2                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  | 2     2  2                          2                                    |             
      Follicle, Ectasia                    |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Inflammation, Chronic                | 2                       2                                                |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Abscess                              |                                        4                                 |             
      Inflammation, Chronic                |          2        1  2              2     2     2  2     2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 8| 2| 2| 2| 2| 9| 0| 2| 2| 2| 6| 6| 2| 2| 2| 6| 2| 2| 2| 2| 6| 6| 6| 6| 6|             
                                           | 5| 9| 9| 9| 9| 8| 1| 9| 9| 9| 1| 2| 3| 9| 9| 1| 9| 9| 9| 9| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                         3  3  2              3        3                  |             
      Duct, Ectasia                        |                                                 2                        |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                       3  2               |             
      Inflammation, Chronic Active         | 2  3  2  2  3  3  2  2  2  2  3     4  3  2  2  3  2                     |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Atrophy                              |                                     3        4           4               |             
      Necrosis                             |                         4                                                |             
      Interstitial Cell, Hyperplasia       | 1  2                 2           1  2        1                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                  +                                       |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                         2                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Congestion                           |                                                                          |             
      Cyst                                 |          X  X                                                            |             
      Hyperplasia, Lymphoid                | 2  2  2  3  2  2  2  3  2  2  3        3     2  2     2  2               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Congestion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Fibrosis                             |                                     3                                    |             
      Hematopoietic Cell Proliferation     |    2  2  2  1  1  1     1     1           1     3  2  1  1               |             
      Necrosis                             |                                        2                                 |             
      Pigmentation                         | 2                 2  2  3     3     3     2        2  2  2               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +               |             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +               |             
      Acinus, Ectasia                      |       2     2        3  2     4     2  3        1                        |             
      Acinus, Hyperplasia                  |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Abscess                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 8| 2| 2| 2| 2| 9| 0| 2| 2| 2| 6| 6| 2| 2| 2| 6| 2| 2| 2| 2| 6| 6| 6| 6| 6|             
                                           | 5| 9| 9| 9| 9| 8| 1| 9| 9| 9| 1| 2| 3| 9| 9| 1| 9| 9| 9| 9| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Cranium, Fibrous Osteodystrophy      |                                     2                                    |             
      Femur, Fibrous Osteodystrophy        |                                     2        2                           |             
      Femur, Hyperostosis                  |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Compression                          | 2                    2        3                                          |             
      Hemorrhage                           | 2                                                                        |             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Congestion                           |                                                                          |             
      Hemorrhage                           |          2  1                                                            |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                   1                                                      |             
      Arteriole, Mineralization            | 2     2        2  2     1  2        2  2  2  2  2  2  2  2               |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Lumen, Hemorrhage                    |    2                                               2     1               |             
      Mucosa, Inflammation, Acute          |       3  3        3  4                                   2               |             
      Nasolacrimal Duct, Hemorrhage        |                                              2                           |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           | 2  2        1                    1  1  1  2           2                  |             
      Olfactory Epithelium, Degeneration   | 1        2  2                 2  1  1  1  1  2  2  2  2  2               |             
      Respiratory Epithelium, Degeneration |          1  1                                1  1     1  2               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Canal, Abscess                       |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +           +                                                         |             
      Cataract                             |                3                                                         |             
      Hemorrhage                           |                                                                          |             
      Posterior Chamber, Synechia          |                                                                          |             
      Retina, Degeneration                 |    3           3                                                         |             
      Sclera, Mineralization               |                3                                                         |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 8| 2| 2| 2| 2| 9| 0| 2| 2| 2| 6| 6| 2| 2| 2| 6| 2| 2| 2| 2| 6| 6| 6| 6| 6|             
                                           | 5| 9| 9| 9| 9| 8| 1| 9| 9| 9| 1| 2| 3| 9| 9| 1| 9| 9| 9| 9| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |                                              X                           |             
      Necrosis                             |                                                                          |             
      Nephropathy, Chronic                 | 2  4  3  4  2  3  2  2  3  2  3  4  4  3  2  2  3  3  4  3               |             
      Renal Tubule, Mineralization         |                                                                          |             
      Renal Tubule, Pigmentation           | 1  2  2  2  2  2  1  2  2  2  1  2  1  2  2  2  2  2  2  1               |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Calculus Micro Observation Only      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Calculus Micro Observation Only      | X                                                                        |             
      Infiltration Cellular, Lymphocyte    |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 7| 0| 2| 2| 2| 3| 8| 2| 2| 2| 2| 2| 3| 3| 3| 6| 6| 1| 8| 3| 6| 6| 6| 6| 6|             
                                           | 0| 0| 9| 9| 9| 0| 1| 9| 9| 9| 9| 9| 0| 0| 0| 4| 7| 4| 8| 0| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +               |             
      Parasite Metazoan                    |                                     X     X                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +               |             
      Parasite Metazoan                    |                         X              X                                 |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Inflammation, Chronic                |                                           3                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Angiectasis                          |                            1        1                                    |             
      Basophilic Focus                     |    X  X  X  X        X  X     X  X  X  X  X           X                  |             
      Congestion                           |                                                                          |             
      Developmental Malformation           |    X                                                                     |             
      Focal Cellular Change                |                                                 X                        |             
      Necrosis                             |    2                                                                     |             
      Vacuolization Cytoplasmic            |                                                 2                        |             
      Bile Duct, Hyperplasia               | 3  4  2  2  1  3  2  3  2  2  2  2  2  2  2  2  2  2  2  2               |             
      Portal, Inflammation, Chronic        |    2  2  1  1  2  2  2  2  1  2  2  2  2  2     2  1  2  2               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                           +        +                     |             
      Fat, Necrosis                        |                                           4        4                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Acinus, Atrophy                      |    2  3  2              2     3  2  2  4  2              2               |             
      Acinus, Hyperplasia                  |                               2                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Infiltration Cellular, Lymphocyte    |                                                 2                        |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Edema                                |                               3                                          |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Mineralization                       |                                              2                           |             
      Mucosa, Dilatation                   |    2  2  2  2     2     2  2     2  2  1                 2               |             
                                            __________________________________________________________________________|             
   Tongue                                  |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 7| 0| 2| 2| 2| 3| 8| 2| 2| 2| 2| 2| 3| 3| 3| 6| 6| 1| 8| 3| 6| 6| 6| 6| 6|             
                                           | 0| 0| 9| 9| 9| 0| 1| 9| 9| 9| 9| 9| 0| 0| 0| 4| 7| 4| 8| 0| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                      +     +  +                          +               |             
      Artery, Inflammation, Chronic        |                      2     4  2                          4               |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Cardiomyopathy, Chronic              |       3  2  3  2  2  3  3  2  1  3  1  3  3  2  2  2  3  2               |             
      Mineralization                       |                                                                          |             
      Pigmentation, Hemosiderin            |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Degeneration, Fatty                  | 1     1     2     1                 2  1     1     2                     |             
      Hyperplasia                          |             2     2              2  2  1           2                     |             
      Infiltration Cellular, Lymphocyte    |                            2                                             |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Hyperplasia                          |             2                    2     2                                 |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Hyperplasia                          |                         2                                                |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  M  +  +  +  M  +  +  +  M  +  +  +               |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hemorrhage            |                                     4                                    |             
      Pars Distalis, Hyperplasia           |       2        2                 1                                       |             
      Pars Distalis, Infarct               |                                                                          |             
      Pars Distalis, Infiltration Cellular,|                                                                          |             
           Lymphocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Ultimobranchial Cyst                 |       X                                                                  |             
      C-Cell, Hyperplasia                  |       2  1  1        2                                                   |             
      Follicle, Ectasia                    |                2  2                    2                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +               |             
      Inflammation, Chronic                |                                        2                                 |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +               |             
      Abscess                              |                                                                          |             
      Inflammation, Chronic                |    2     2        2        2     2     3  3                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 7| 0| 2| 2| 2| 3| 8| 2| 2| 2| 2| 2| 3| 3| 3| 6| 6| 1| 8| 3| 6| 6| 6| 6| 6|             
                                           | 0| 0| 9| 9| 9| 0| 1| 9| 9| 9| 9| 9| 0| 0| 0| 4| 7| 4| 8| 0| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |       3     3        2  2     2                          2               |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                               4           2                              |             
      Inflammation, Chronic Active         |    2  2  2  3  3  3  2  2  3     3  3  3     3  3  3  2  3               |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +               |             
      Atrophy                              |    4                 4              3                                    |             
      Necrosis                             |                                                                          |             
      Interstitial Cell, Hyperplasia       | 2  2        2        1                                   2               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                +                                                         |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Hemorrhage                           |             3                                                            |             
      Necrosis                             |                3                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Mediastinal, Congestion              |                         2                                                |             
      Mediastinal, Hemorrhage              |                                              3                           |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Congestion                           |                                                                          |             
      Cyst                                 |       X                                                                  |             
      Hyperplasia, Lymphoid                |    3  2  2  2     2  2  2  2  2  2  2  2  2        2     2               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Congestion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Fibrosis                             |       2  3           3                                   2               |             
      Hematopoietic Cell Proliferation     |       1  2  2     1     1  2  1     2  2  2     2     2                  |             
      Necrosis                             | 3                                                                        |             
      Pigmentation                         |       2              2        2     2  2        2  3  2                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +               |             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +               |             
      Acinus, Ectasia                      |                   3  2        4  2     2  2        2  2  2               |             
      Acinus, Hyperplasia                  |    2                 2                                                   |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Abscess                              |                               4                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 7| 0| 2| 2| 2| 3| 8| 2| 2| 2| 2| 2| 3| 3| 3| 6| 6| 1| 8| 3| 6| 6| 6| 6| 6|             
                                           | 0| 0| 9| 9| 9| 0| 1| 9| 9| 9| 9| 9| 0| 0| 0| 4| 7| 4| 8| 0| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Cranium, Fibrous Osteodystrophy      |                                                                          |             
      Femur, Fibrous Osteodystrophy        |                      2                                                   |             
      Femur, Hyperostosis                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Compression                          |                               2                                          |             
      Hemorrhage                           | 2                                                                        |             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Congestion                           |                                                    3                     |             
      Hemorrhage                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 2        2  2                                   2                        |             
      Arteriole, Mineralization            | 2           2  1        2     1     2  2  2     2     2  2               |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Lumen, Hemorrhage                    |       1     1  2                          2                              |             
      Mucosa, Inflammation, Acute          |    2        1                                2        3                  |             
      Nasolacrimal Duct, Hemorrhage        |                                     2  2                                 |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |       2                    2  1                 1                        |             
      Olfactory Epithelium, Degeneration   |       2     2  2  2  2  2  2  2  2     2  1     2  2                     |             
      Respiratory Epithelium, Degeneration |                                              2                           |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                  +                                       |             
      Canal, Abscess                       |                                  4                                       |             
                                            __________________________________________________________________________|             
   Eye                                     |             +     +     +              +        +                        |             
      Cataract                             |             2     4     4              4        4                        |             
      Hemorrhage                           |                         4              3                                 |             
      Posterior Chamber, Synechia          |                                                 4                        |             
      Retina, Degeneration                 |             4     4     4              4        4                        |             
      Sclera, Mineralization               |             2                                                            |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 4| 5| 6| 6| 7| 4| 4| 4| 4| 4|             
                             DAY ON TEST   | 7| 0| 2| 2| 2| 3| 8| 2| 2| 2| 2| 2| 3| 3| 3| 6| 6| 1| 8| 3| 6| 6| 6| 6| 6|             
                                           | 0| 0| 9| 9| 9| 0| 1| 9| 9| 9| 9| 9| 0| 0| 0| 4| 7| 4| 8| 0| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    UNTREATD                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |                X                                                         |             
      Necrosis                             |                4                                                         |             
      Nephropathy, Chronic                 | 2  3  2  4  4  2  3  4  4  3  4  3  2  2  4  1  2  1  2  3               |             
      Renal Tubule, Mineralization         |                                              4                           |             
      Renal Tubule, Pigmentation           | 2  2  1  1  1  2  2  2  2  2  2     2  2  1     1        2               |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                 +  +                     |             
      Calculus Micro Observation Only      |                                                 X  X                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |             
      Calculus Micro Observation Only      |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 6| 7| 7| 6| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 9| 4| 1| 3| 4| 1| 3| 3| 3|                                            |            |
                                           | 5| 3| 0| 7| 0| 0| 2| 0| 0| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Parasite Metazoan                    |                   X        X                                             |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Parasite Metazoan                    |                                                                          |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Parasite Metazoan                    |                   X                                                      |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  A  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +                                             |  49        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +                                             |  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Angiectasis                          |                         1                                                |      4  1.5|
      Basophilic Focus                     |          X  X  X     X  X  X                                             |     34     |
      Congestion                           |                   3                                                      |      1  3.0|
      Developmental Malformation           | X                 X     X                                                |      7     |
      Focal Cellular Change                |                   X                                                      |      2     |
      Necrosis                             |                                                                          |      3  1.7|
      Vacuolization Cytoplasmic            |                   1                                                      |      4  1.5|
      Bile Duct, Hyperplasia               | 2  2  2  2  2  2  2  2  2  2                                             |     49  2.2|
      Portal, Inflammation, Chronic        | 2  2  2     2  2  1  2  2  2                                             |     46  1.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Fat, Necrosis                        |                                                                          |      4  3.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Acinus, Atrophy                      | 2           2        2  2  3                                             |     25  2.1|
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
      Duct, Ectasia                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      5  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Edema                                |                                                                          |      1  3.0|
      Hyperkeratosis                       |                                                                          |      1  3.0|
      Inflammation, Acute                  |                   2                                                      |      2  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  M  +  +  +  +                                             |  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 6| 7| 7| 6| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 9| 4| 1| 3| 4| 1| 3| 3| 3|                                            |            |
                                           | 5| 3| 0| 7| 0| 0| 2| 0| 0| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                                                                          |      2  2.5|
      Mucosa, Dilatation                   |       2  2  2        2     2                                             |     30  1.7|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   6        |
      Artery, Inflammation, Chronic        |                                                                          |      6  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Cardiomyopathy, Chronic              | 2     2  3  2  3  1  2  2  3                                             |     47  2.2|
      Mineralization                       |                                                                          |      2  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Accessory Adrenal Cortical Nodule    |                   X                                                      |      2     |
      Degeneration, Fatty                  |       2           1        2                                             |     26  1.7|
      Hyperplasia                          |             2  1  2  1  2                                                |     15  1.8|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
      Pigmentation                         | 1                                                                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hyperplasia                          |       2           2     1                                                |     11  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +                                             |  39        |
      Hypertrophy                          |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Pars Distalis, Cyst                  |                                                                          |      3     |
      Pars Distalis, Hemorrhage            |                                                                          |      2  3.5|
      Pars Distalis, Hyperplasia           |       2  2                                                               |     10  2.0|
      Pars Distalis, Infarct               |                                                                          |      1  4.0|
      Pars Distalis, Infiltration Cellular,|                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Ultimobranchial Cyst                 | X                                                                        |      2     |
      C-Cell, Hyperplasia                  |                                                                          |      8  1.8|
      Follicle, Ectasia                    |          2              3                                                |      6  2.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 6| 7| 7| 6| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 9| 4| 1| 3| 4| 1| 3| 3| 3|                                            |            |
                                           | 5| 3| 0| 7| 0| 0| 2| 0| 0| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Inflammation, Chronic                |                            2                                             |      4  2.0|
      Inflammation, Chronic Active         |                      1                                                   |      1  1.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Abscess                              |                                                                          |      1  4.0|
      Inflammation, Chronic                | 2     2  2              2                                                |     19  2.1|
      Inflammation, Chronic Active         |                   2        3                                             |     13  2.5|
      Duct, Ectasia                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Inflammation, Acute                  |    4                                                                     |      1  4.0|
      Inflammation, Chronic                |       1                    2                                             |      6  2.3|
      Inflammation, Chronic Active         |          2  3  2  4  2  3                                                |     40  2.6|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Atrophy                              |                                                                          |      6  3.7|
      Necrosis                             |                                                                          |      1  4.0|
      Interstitial Cell, Hyperplasia       |       1           1                                                      |     13  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  M  +  +  +  +  +  +  +  +                                             |  49        |
      Mediastinal, Congestion              |                                                                          |      1  2.0|
      Mediastinal, Hemorrhage              |                                                                          |      1  3.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +                                             |  49        |
      Congestion                           |                   2                                                      |      1  2.0|
      Cyst                                 |             X                                                            |      4     |
      Hyperplasia, Lymphoid                | 2           2  2  3  2     2                                             |     37  2.2|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  +  +  +  +                                             |  49        |
      Congestion                           |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Fibrosis                             |                2                                                         |      6  2.5|
      Hematopoietic Cell Proliferation     |          2  1     1  2     2                                             |     30  1.6|
      Necrosis                             |                                                                          |      2  2.5|
      Pigmentation                         | 2  3        2  3  3  2     2                                             |     25  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 6| 7| 7| 6| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 9| 4| 1| 3| 4| 1| 3| 3| 3|                                            |            |
                                           | 5| 3| 0| 7| 0| 0| 2| 0| 0| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  47        |
      Congestion                           |                3                                                         |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  47        |
      Acinus, Ectasia                      |             2  3  2                                                      |     20  2.4|
      Acinus, Hyperplasia                  |                                                                          |      2  2.0|
      Duct, Ectasia                        | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Abscess                              |                3                                                         |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Cranium, Fibrous Osteodystrophy      |                                                                          |      1  2.0|
      Femur, Fibrous Osteodystrophy        |                                                                          |      3  2.0|
      Femur, Hyperostosis                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Compression                          | X                                                                        |      5  2.3|
      Hemorrhage                           |                                                                          |      2  2.0|
      Hydrocephalus                        | 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Congestion                           | 2  3           3                                                         |      4  2.8|
      Hemorrhage                           |       2        2     1                                                   |      5  1.6|
      Alveolar Epithelium, Hyperplasia     |       3        2                                                         |      2  2.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |          2                                                               |      6  1.8|
      Arteriole, Mineralization            | 2  1     2     2        2  2                                             |     31  1.9|
      Interstitium, Inflammation, Chronic  |                         1                                                |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Lumen, Hemorrhage                    | 3                          2                                             |      9  1.8|
      Mucosa, Inflammation, Acute          |    2              4  2                                                   |     12  2.6|
      Nasolacrimal Duct, Hemorrhage        |                                                                          |      3  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                         2  2                                             |     14  1.6|
      Olfactory Epithelium, Degeneration   | 1        2  2  1     1  1                                                |     32  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 6| 7| 7| 6| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 9| 4| 1| 3| 4| 1| 3| 3| 3|                                            |            |
                                           | 5| 3| 0| 7| 0| 0| 2| 0| 0| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    UNTREATD                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     CONTROL                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Respiratory Epithelium, Degeneration |                                                                          |      7  1.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
      Canal, Abscess                       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |             +           +  +                                             |  10        |
      Cataract                             |             4           4                                                |      8  3.6|
      Hemorrhage                           |             3                                                            |      3  3.3|
      Posterior Chamber, Synechia          |                                                                          |      1  4.0|
      Retina, Degeneration                 |             4           4                                                |      9  3.8|
      Sclera, Mineralization               |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |       +                                                                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Cyst                                 |                                                                          |      2     |
      Necrosis                             |                                                                          |      1  4.0|
      Nephropathy, Chronic                 | 2  2  2  4  3  2  4  3  3  3                                             |     50  2.8|
      Renal Tubule, Mineralization         |                                                                          |      1  4.0|
      Renal Tubule, Pigmentation           | 2     2  2  2     1  1  1  2                                             |     44  1.7|
                                            __________________________________________________________________________|____________|
   Urethra                                 | +                                                                        |   3        |
      Calculus Micro Observation Only      | X                                                                        |      3     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  A  +  +  +  +  +  +  +  +                                             |  49        |
      Calculus Micro Observation Only      |                                                                          |      1     |
      Infiltration Cellular, Lymphocyte    |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 6| 7| 7| 4| 5| 7| 7| 7| 5| 6| 6| 6| 7| 4| 4| 4| 4| 4| 4| 6| 6| 6| 7|             
                             DAY ON TEST   | 5| 8| 8| 3| 3| 5| 7| 0| 3| 3| 9| 4| 4| 6| 3| 6| 6| 6| 6| 6| 9| 4| 9| 9| 3|             
                                           | 4| 2| 8| 0| 0| 8| 5| 1| 0| 0| 7| 6| 6| 8| 0| 2| 2| 2| 2| 2| 4| 7| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Parasite Metazoan                    |             X                             X                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Parasite Metazoan                    |                            X                                             |             
      Arteriole, Inflammation, Chronic     |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Parasite Metazoan                    |                      X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Inflammation, Chronic Active         |             3                                                            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Angiectasis                          |    1                                                           1     2   |             
      Basophilic Focus                     |    X     X  X           X           X  X  X                 X  X  X  X  X|             
      Congestion                           |                                                                          |             
      Developmental Malformation           |                                                                          |             
      Granuloma                            |                                           1                              |             
      Necrosis                             |                1                                                         |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Arteriole, Inflammation, Chronic     |                                                                          |             
      Bile Duct, Hyperplasia               | 2  2  2  2  2  2  2  4  2  2  2  2  3  1  1                 2  2  2  1  2|             
      Portal, Inflammation, Chronic        | 2  2  2  1  2  2  2  2     2  2  2  2  2  2                    2  2     2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +     +     +  +                       +     +      |             
      Artery, Inflammation, Chronic        |                                                                          |             
      Fat, Necrosis                        |                      3     4     4                                3      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 M  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                   2                                                      |             
      Inflammation, Acute                  |                                                                          |             
      Pigmentation                         |                                                                          |             
      Acinus, Atrophy                      |    2  1  2  2  2        2                 2                    2  2     2|             
      Artery, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                            1                                             |             
      Acinus, Atrophy                      |                                                                          |             
      Duct, Mineralization                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 6| 7| 7| 4| 5| 7| 7| 7| 5| 6| 6| 6| 7| 4| 4| 4| 4| 4| 4| 6| 6| 6| 7|             
                             DAY ON TEST   | 5| 8| 8| 3| 3| 5| 7| 0| 3| 3| 9| 4| 4| 6| 3| 6| 6| 6| 6| 6| 9| 4| 9| 9| 3|             
                                           | 4| 2| 8| 0| 0| 8| 5| 1| 0| 0| 7| 6| 6| 8| 0| 2| 2| 2| 2| 2| 4| 7| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Mucosa, Dilatation                   |          2  2     2  2  2        2  2  2  2                          2   |             
      Mucosa, Erosion                      |                2                                                         |             
      Mucosa, Ulcer                        |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                   +           +        +                                 |             
      Peridontal Tissue, Hemorrhage        |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic                         |                   3                                                      |             
      Pulp, Necrosis                       |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Artery, Inflammation, Chronic        |                                                                          |             
      Artery, Thrombosis                   |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 2  2  3  2  3        2  3  4  2  2  2  2  1                 3  1  3  2  3|             
      Mineralization                       |                                                                          |             
      Artery, Inflammation, Chronic        |                                                                          |             
      Artery, Mineralization               |                                                                          |             
      Atrium Left, Thrombosis              |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                X         |             
      Cyst                                 |                                           X                              |             
      Degeneration, Fatty                  |    2  2  2  2     1  2  1  2        2  1                    2     2  2   |             
      Hyperplasia                          |          2  2        2  1     2     2                          2        1|             
      Hypertrophy                          |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |    2                 1        1     3                             2      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 M  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +                 +  +  +  +  +|             
      Hypertrophy                          |       2  2                                                               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Pars Distalis, Cyst                  |    X                                                                 X   |             
      Pars Distalis, Hyperplasia           |    2              2                                                  2   |             
      Pars Intermedia, Angiectasis         |                               2                                          |             
      Pars Intermedia, Cyst                |                               X                                          |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 6| 7| 7| 4| 5| 7| 7| 7| 5| 6| 6| 6| 7| 4| 4| 4| 4| 4| 4| 6| 6| 6| 7|             
                             DAY ON TEST   | 5| 8| 8| 3| 3| 5| 7| 0| 3| 3| 9| 4| 4| 6| 3| 6| 6| 6| 6| 6| 9| 4| 9| 9| 3|             
                                           | 4| 2| 8| 0| 0| 8| 5| 1| 0| 0| 7| 6| 6| 8| 0| 2| 2| 2| 2| 2| 4| 7| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Ultimobranchial Cyst                 | X                                                                        |             
      C-Cell, Hyperplasia                  |          2  2        2  2              1                             1  1|             
      Follicle, Ectasia                    |                                           2                              |             
      Follicle, Hyperplasia                |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Inflammation, Chronic Active         |       3                                                                  |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Inflammation, Chronic                |          3        1        2        2     2                    2  2  2   |             
      Inflammation, Chronic Active         |    3                    2                                               2|             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                   1                                                  2   |             
      Inflammation, Chronic Active         | 3  3  3  3  3        2  3  3  3  4  2     3                    2  2      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Artery, Inflammation, Chronic        |                            2                                             |             
      Interstitial Cell, Hyperplasia       |    1        1  1  3  3     1  1                             1            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                  +                                       |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Hemorrhage                           |             4                                                            |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Mediastinal, Congestion              |                                                                   3     2|             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Pancreatic, Congestion               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |          X        X                       X                              |             
      Hyperplasia, Lymphoid                |       2  2  2  2  3  3  2  2  2  2  2  3  2                    2  3  2  2|             
      Inflammation, Acute                  |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 6| 7| 7| 4| 5| 7| 7| 7| 5| 6| 6| 6| 7| 4| 4| 4| 4| 4| 4| 6| 6| 6| 7|             
                             DAY ON TEST   | 5| 8| 8| 3| 3| 5| 7| 0| 3| 3| 9| 4| 4| 6| 3| 6| 6| 6| 6| 6| 9| 4| 9| 9| 3|             
                                           | 4| 2| 8| 0| 0| 8| 5| 1| 0| 0| 7| 6| 6| 8| 0| 2| 2| 2| 2| 2| 4| 7| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Congestion                           |                                        2                                 |             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Fibrosis                             |                                        3                                 |             
      Hematopoietic Cell Proliferation     | 3  2  3     2  3  3     2        3     3  1                 2  2  1  3  2|             
      Hyperplasia, Lymphoid                |                2                 2                                       |             
      Pigmentation                         | 3        2  2           2     3        3  2                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 M  +  +  +  +|             
      Acinus, Ectasia                      | 2           3        2  2        2     2                                 |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Alopecia                             |                                                                          |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                               4                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Compression                          | X                          2                                             |             
      Hemorrhage                           |                               2                                          |             
      Hydrocephalus                        | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |    2                 1                                         2     2   |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 2                    2           1        1                       2     2|             
      Alveolus, Mineralization             |                                                                          |             
      Arteriole, Mineralization            |    2  1  2  2     2  2  2  1     2  2  2  2                       2  2  2|             
      Bronchiole, Inflammation, Acute      |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 6| 7| 7| 4| 5| 7| 7| 7| 5| 6| 6| 6| 7| 4| 4| 4| 4| 4| 4| 6| 6| 6| 7|             
                             DAY ON TEST   | 5| 8| 8| 3| 3| 5| 7| 0| 3| 3| 9| 4| 4| 6| 3| 6| 6| 6| 6| 6| 9| 4| 9| 9| 3|             
                                           | 4| 2| 8| 0| 0| 8| 5| 1| 0| 0| 7| 6| 6| 8| 0| 2| 2| 2| 2| 2| 4| 7| 9| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic Active                   |                                                                         3|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Lumen, Hemorrhage                    |    1                 1                                               1   |             
      Mucosa, Inflammation, Acute          |                               3           4                       2      |             
      Mucosa, Inflammation, Chronic        | 2                                                                        |             
      Nasolacrimal Duct, Hemorrhage        |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                   2     3                                      2         |             
      Olfactory Epithelium, Degeneration   |       2  2     1  2  1  2        2  2     2                    2     2  2|             
      Respiratory Epithelium, Degeneration |          2              1        1  1                                2   |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                   +           +                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +     +  +  +                                 |             
      Cataract                             |                            4     3  4                                    |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Anterior Chamber, Hemorrhage         |                                        3                                 |             
      Cornea, Inflammation, Acute          |                                        4                                 |             
      Posterior Chamber, Synechia          |                                                                          |             
      Retina, Degeneration                 |                            4     4  4                                    |             
      Sclera, Mineralization               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |    X                                                                     |             
      Infarct                              |                                                                          |             
      Nephropathy, Chronic                 | 2  3  4  4  4  1  2  3  4  4  2  2  3  4  3                 2  3  3  3  3|             
      Cortex, Cyst                         |                                                                      X   |             
      Renal Tubule, Pigmentation           | 2  1  1  1  1        2  1  1  2  1  1  1  1                    1  2  2  2|             
                                            __________________________________________________________________________|             
   Urethra                                 |       +                    +                                             |             
      Calculus Micro Observation Only      |       X                    X                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 6| 7| 7| 6| 6| 7| 7| 7| 4| 5| 5| 7| 7| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 9| 9| 3| 3| 4| 8| 2| 3| 3| 6| 0| 7| 1| 3| 6| 6| 6| 6| 6| 7| 2| 0| 3| 3|             
                                           | 0| 9| 9| 1| 1| 4| 9| 4| 1| 1| 1| 3| 4| 0| 1| 2| 2| 2| 2| 2| 0| 5| 9| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +                 +  +  +  +  +|             
      Parasite Metazoan                    | X     X  X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
      Arteriole, Inflammation, Chronic     |                               3                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Parasite Metazoan                    |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Angiectasis                          |          2     2        2                                                |             
      Basophilic Focus                     |    X     X  X        X  X  X              X                       X  X  X|             
      Congestion                           |          2                                                               |             
      Developmental Malformation           |                                  X                                       |             
      Granuloma                            |                                                                          |             
      Necrosis                             |                                                                   1      |             
      Vacuolization Cytoplasmic            |                                                             2            |             
      Arteriole, Inflammation, Chronic     |                               3                                          |             
      Bile Duct, Hyperplasia               | 2  2  2  2  2  4  2  3  2  2  2  2  3  2  2                 2  2  2  2  3|             
      Portal, Inflammation, Chronic        |    2  2  2  2  2  1  2  2  2  1  2  2  2  2                 2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +           +                                   +  +   |             
      Artery, Inflammation, Chronic        |                               4                                          |             
      Fat, Necrosis                        |                   4                                                  4   |             
                                            __________________________________________________________________________|             
   Pancreas                                | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Pigmentation                         |                                                                   2      |             
      Acinus, Atrophy                      |       1     2     3        2  2        3  1                          1   |             
      Artery, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
      Duct, Mineralization                 |                                                                   2      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Hyperkeratosis                       |                                                                   3      |             
      Inflammation, Acute                  |                                        2                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Mineralization                       |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 6| 7| 7| 6| 6| 7| 7| 7| 4| 5| 5| 7| 7| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 9| 9| 3| 3| 4| 8| 2| 3| 3| 6| 0| 7| 1| 3| 6| 6| 6| 6| 6| 7| 2| 0| 3| 3|             
                                           | 0| 9| 9| 1| 1| 4| 9| 4| 1| 1| 1| 3| 4| 0| 1| 2| 2| 2| 2| 2| 0| 5| 9| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Mucosa, Dilatation                   |          2  2     2     2              2                    2        2  2|             
      Mucosa, Erosion                      |                                                                          |             
      Mucosa, Ulcer                        |                                  3                                       |             
                                            __________________________________________________________________________|             
   Tooth                                   |                         +                                                |             
      Peridontal Tissue, Hemorrhage        |                         2                                                |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
      Pulp, Necrosis                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                               +                                          |             
      Artery, Inflammation, Chronic        |                               4                                          |             
      Artery, Thrombosis                   |                               X                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Cardiomyopathy, Chronic              |    2  2  1  2  3  2  3  3  2  2  2     2  3                 3  2  2  2  3|             
      Mineralization                       |                   2                                                      |             
      Artery, Inflammation, Chronic        |                                                                          |             
      Artery, Mineralization               |          1                                                               |             
      Atrium Left, Thrombosis              |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Cyst                                 |                                                                          |             
      Degeneration, Fatty                  |       2  2        1     1  2     2  2  1                    2        2   |             
      Hyperplasia                          | 2        2  2                             2                             2|             
      Hypertrophy                          |                                                             2            |             
      Necrosis                             |                                  4                                       |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |          2        2     2                 2                 1     2      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Hyperplasia                          |                                        2                                 |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  M  +  +|             
      Hypertrophy                          |                            2                                             |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |       2        2     2     2        2     2                       2     2|             
      Pars Intermedia, Angiectasis         |                                                                          |             
      Pars Intermedia, Cyst                |                                                                          |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 6| 7| 7| 6| 6| 7| 7| 7| 4| 5| 5| 7| 7| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 9| 9| 3| 3| 4| 8| 2| 3| 3| 6| 0| 7| 1| 3| 6| 6| 6| 6| 6| 7| 2| 0| 3| 3|             
                                           | 0| 9| 9| 1| 1| 4| 9| 4| 1| 1| 1| 3| 4| 0| 1| 2| 2| 2| 2| 2| 0| 5| 9| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |          2                                                               |             
      Infiltration Cellular, Lymphocyte    |                            2                                             |             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |    2  2        2                       2                                2|             
      Follicle, Ectasia                    |                            2                                             |             
      Follicle, Hyperplasia                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Inflammation, Chronic                |       2     2     2  2  2              3  2                    2  2      |             
      Inflammation, Chronic Active         |    3                       3  2  3                          2        3   |             
      Duct, Ectasia                        |                                  3                                   2   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Hemorrhage                           |                2                                                         |             
      Inflammation, Acute                  |                                  4                                       |             
      Inflammation, Chronic                |                         1  1                                      2      |             
      Inflammation, Chronic Active         |    2  2  3  4     4                 2  4  2                 4  3     3   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Mineralization                       |                               2                                          |             
      Artery, Inflammation, Chronic        |                                                             2            |             
      Interstitial Cell, Hyperplasia       |    1                          1  1                             2         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                      2                                                   |             
      Pancreatic, Congestion               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +                 +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                         X|             
      Hyperplasia, Lymphoid                |    2  2  2  2     3  2  2  2     2  3                       2  2  2  3  3|             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 6| 7| 7| 6| 6| 7| 7| 7| 4| 5| 5| 7| 7| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 9| 9| 3| 3| 4| 8| 2| 3| 3| 6| 0| 7| 1| 3| 6| 6| 6| 6| 6| 7| 2| 0| 3| 3|             
                                           | 0| 9| 9| 1| 1| 4| 9| 4| 1| 1| 1| 3| 4| 0| 1| 2| 2| 2| 2| 2| 0| 5| 9| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +   |             
      Congestion                           |                                                                          |             
      Edema                                |                                           3                              |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                               4                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Fibrosis                             |                3                                                         |             
      Hematopoietic Cell Proliferation     |    3  1  2  2     3  1  2  1  4  4        2                 3        2  2|             
      Hyperplasia, Lymphoid                |    2                                                                     |             
      Pigmentation                         | 2                 3  2     2           2  2                 2  3     2  2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Congestion                           |                                                                2         |             
      Cyst                                 |                   X                                                      |             
      Hyperplasia, Lymphoid                |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +                 +  +  +  +  +|             
      Acinus, Ectasia                      |       2           2        2           2                    4  4         |             
      Duct, Ectasia                        |                                  2                                       |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Alopecia                             |                                        X                                 |             
      Cyst Epithelial Inclusion            |                                           X                              |             
      Hyperkeratosis                       |                                                                   4      |             
      Inflammation, Chronic Active         |                                        2                                 |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Compression                          |                   2                                         X  X         |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Congestion                           |          3                                                     3         |             
      Hemorrhage                           |                      2              3  2                                 |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |    2        2  1                       2  2                              |             
      Alveolus, Mineralization             |                   2                                            1         |             
      Arteriole, Mineralization            | 2  2  2  2     2     2  1  2        2  2                    2        1  2|             
      Bronchiole, Inflammation, Acute      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 4| 6| 6| 7| 7| 6| 6| 7| 7| 7| 4| 5| 5| 7| 7| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 0| 9| 9| 3| 3| 4| 8| 2| 3| 3| 6| 0| 7| 1| 3| 6| 6| 6| 6| 6| 7| 2| 0| 3| 3|             
                                           | 0| 9| 9| 1| 1| 4| 9| 4| 1| 1| 1| 3| 4| 0| 1| 2| 2| 2| 2| 2| 0| 5| 9| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    5.0%                                   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Interstitium, Inflammation, Chronic  |             2                                                            |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
          Active                           |                                           3                              |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic Active                   |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Lumen, Hemorrhage                    |                            2  1                                      2   |             
      Mucosa, Inflammation, Acute          |                4  2  3                                                   |             
      Mucosa, Inflammation, Chronic        |    2                                                                     |             
      Nasolacrimal Duct, Hemorrhage        |                                                                   2      |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |             2                       4                          2     2  2|             
      Olfactory Epithelium, Degeneration   | 1  2  1  2  2  2     2  2  2        2  2  1                 2  2  2  2  2|             
      Respiratory Epithelium, Degeneration |                1  1                                                      |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                      4                                                   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Inflammation, Acute                  |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +        +           +  +                             +  +|             
      Cataract                             |                2        4           4                                4  4|             
      Hemorrhage                           |                4        3                                                |             
      Inflammation, Chronic                |                                        4                                 |             
      Anterior Chamber, Hemorrhage         |                                                                          |             
      Cornea, Inflammation, Acute          |                                                                          |             
      Posterior Chamber, Synechia          |                                                                      3   |             
      Retina, Degeneration                 |                4        4           4                                4  4|             
      Sclera, Mineralization               |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Infarct                              |                               4                                          |             
      Nephropathy, Chronic                 | 2  3  3  2  4  3  4  3  3  4  2  2  1  4  3                 4  2  2  4  3|             
      Cortex, Cyst                         |                                                                          |             
      Renal Tubule, Pigmentation           |    2  3  2  1  2  2  2  2  1        2  2  2                    1  4  2  2|             
                                            __________________________________________________________________________|             
   Urethra                                 |                            +                                             |             
      Calculus Micro Observation Only      |                            X                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +|             
      Calculus Micro Observation Only      |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 2| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 0| 3| 3| 3| 5| 8| 7| 3| 3|                                            |            |
                                           | 7| 0| 1| 1| 1| 8| 2| 9| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  A  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +                                             |  48        |
      Parasite Metazoan                    |                                                                          |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +                                             |  49        |
      Parasite Metazoan                    |    X                 X                                                   |      3     |
      Arteriole, Inflammation, Chronic     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  +                                             |  49        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +                                             |  49        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Angiectasis                          |                                                                          |      6  1.7|
      Basophilic Focus                     |             X           X  X                                             |     25     |
      Congestion                           |                                                                          |      1  2.0|
      Developmental Malformation           |                      X     X                                             |      3     |
      Granuloma                            |                                                                          |      1  1.0|
      Necrosis                             |                2                                                         |      3  1.3|
      Vacuolization Cytoplasmic            |          2                                                               |      2  2.0|
      Arteriole, Inflammation, Chronic     |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia               | 2  3  2  2  2  2  2  4  2  2                                             |     50  2.2|
      Portal, Inflammation, Chronic        |    2  1  2  1  2  2  3  2  2                                             |     45  1.9|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +  +                                             |  12        |
      Artery, Inflammation, Chronic        |                                                                          |      1  4.0|
      Fat, Necrosis                        |                         4  4                                             |      8  3.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Inflammation, Acute                  |                4                                                         |      1  4.0|
      Pigmentation                         |                                                                          |      1  2.0|
      Acinus, Atrophy                      |    2  2           3  4  2                                                |     23  2.0|
      Artery, Inflammation, Chronic        |             3           3                                                |      2  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Acinus, Atrophy                      |          2                                                               |      1  2.0|
      Duct, Mineralization                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  68                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 2| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 0| 3| 3| 3| 5| 8| 7| 3| 3|                                            |            |
                                           | 7| 0| 1| 1| 1| 8| 2| 9| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hyperkeratosis                       |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Mineralization                       |                                                                          |      1  2.0|
      Mucosa, Dilatation                   |    1  2  2  1        2  2                                                |     24  1.9|
      Mucosa, Erosion                      |                                                                          |      1  2.0|
      Mucosa, Ulcer                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   4        |
      Peridontal Tissue, Hemorrhage        |                                                                          |      1  2.0|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      1  3.0|
      Pulp, Necrosis                       |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Artery, Inflammation, Chronic        |                                                                          |      1  4.0|
      Artery, Thrombosis                   |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Cardiomyopathy, Chronic              | 2  3  3  2  2     2  2  3  3                                             |     45  2.3|
      Mineralization                       |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic        |          3                                                               |      1  3.0|
      Artery, Mineralization               |             2                                                            |      2  1.5|
      Atrium Left, Thrombosis              |                                                                          |      2     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Accessory Adrenal Cortical Nodule    |          X                                                               |      2     |
      Cyst                                 |                                                                          |      1     |
      Degeneration, Fatty                  | 2        3        2  1                                                   |     27  1.8|
      Hyperplasia                          | 2                                                                        |     14  1.9|
      Hypertrophy                          |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  4.0|
      Pigmentation                         |    1     2        2  2  2  2                                             |      6  1.8|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Cyst                                 |                         X                                                |      1     |
      Hyperplasia                          | 2                                                                        |     12  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 2| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 0| 3| 3| 3| 5| 8| 7| 3| 3|                                            |            |
                                           | 7| 0| 1| 1| 1| 8| 2| 9| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  M  +  +  +  +  M  +                                             |  45        |
      Hypertrophy                          |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Pars Distalis, Cyst                  |                                                                          |      2     |
      Pars Distalis, Hyperplasia           |    2                                                                     |     12  2.0|
      Pars Intermedia, Angiectasis         |                                                                          |      1  2.0|
      Pars Intermedia, Cyst                |                            X                                             |      2     |
      Pars Intermedia, Hyperplasia         |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Ultimobranchial Cyst                 | X                                                                        |      2     |
      C-Cell, Hyperplasia                  |                                                                          |     12  1.8|
      Follicle, Ectasia                    |                                                                          |      2  2.0|
      Follicle, Hyperplasia                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Inflammation, Chronic                |       2           3     2                                                |     20  2.1|
      Inflammation, Chronic Active         |    3     3     2     3     3                                             |     14  2.6|
      Duct, Ectasia                        |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  4.0|
      Inflammation, Chronic                |       1                                                                  |      6  1.3|
      Inflammation, Chronic Active         | 3  2     3  4     4  3     2                                             |     32  2.9|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Mineralization                       |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic        |                                                                          |      2  2.0|
      Interstitial Cell, Hyperplasia       |          1        2                                                      |     14  1.4|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 2| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 0| 3| 3| 3| 5| 8| 7| 3| 3|                                            |            |
                                           | 7| 0| 1| 1| 1| 8| 2| 9| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  A  +  +  +  +                                             |  49        |
      Hemorrhage                           |                         3                                                |      2  3.5|
      Myelofibrosis                        |                      4                                                   |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Mediastinal, Congestion              |                   3                                                      |      3  2.7|
      Mediastinal, Hemorrhage              |                3                                                         |      1  3.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  2.0|
      Pancreatic, Congestion               |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Congestion                           |                3                                                         |      1  3.0|
      Cyst                                 |                                                                          |      4     |
      Hyperplasia, Lymphoid                |       2  2  3     2  2  2  2                                             |     39  2.2|
      Inflammation, Acute                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Congestion                           |                                                                          |      1  2.0|
      Edema                                |                                                                          |      1  3.0|
      Hemorrhage                           |                4                                                         |      1  4.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Fibrosis                             |          2        2                                                      |      4  2.5|
      Hematopoietic Cell Proliferation     | 1  2  3  1  2     3     2  1                                             |     37  2.2|
      Hyperplasia, Lymphoid                |                                                                          |      3  2.0|
      Pigmentation                         |       2  2  2  2        2  2                                             |     23  2.2|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Congestion                           |                                                                          |      1  2.0|
      Cyst                                 |                   X                                                      |      2     |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Acinus, Ectasia                      | 2        4        3  2                                                   |     16  2.5|
      Duct, Ectasia                        |                   3                                                      |      2  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Alopecia                             |                                                                          |      1     |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Hyperkeratosis                       |                   4                                                      |      2  4.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 2| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 0| 3| 3| 3| 5| 8| 7| 3| 3|                                            |            |
                                           | 7| 0| 1| 1| 1| 8| 2| 9| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Ulcer                                |                   4                                                      |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Compression                          |          X                                                               |      6  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hydrocephalus                        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Congestion                           |             2  4        2                                                |      5  2.8|
      Hemorrhage                           |       1  2     2        2  1                                             |     12  1.8|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |          2  2                                                            |     13  1.8|
      Alveolus, Mineralization             |                                                                          |      2  1.5|
      Arteriole, Mineralization            |          2  2     2  2  2  2                                             |     34  1.9|
      Bronchiole, Inflammation, Acute      |                                                                          |      1  1.0|
      Interstitium, Inflammation, Chronic  |                                                                          |      1  2.0|
      Interstitium, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                                                          |      1  3.0|
      Peribronchiolar, Inflammation,       |                                                                          |            |
          Chronic Active                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Lumen, Hemorrhage                    |          1                                                               |      7  1.3|
      Mucosa, Inflammation, Acute          | 2  2                 2                                                   |      9  2.7|
      Mucosa, Inflammation, Chronic        |                                                                          |      2  2.0|
      Nasolacrimal Duct, Hemorrhage        |    2                                                                     |      2  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      8  2.4|
      Olfactory Epithelium, Degeneration   | 2  2  2  2  2     2  2  2  2                                             |     38  1.9|
      Respiratory Epithelium, Degeneration |                                                                          |      7  1.3|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 2| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 0| 3| 3| 3| 5| 8| 7| 3| 3|                                            |            |
                                           | 7| 0| 1| 1| 1| 8| 2| 9| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    5.0%                                   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +     +           +     +                                             |  14        |
      Cataract                             |    4     4           3     4                                             |     12  3.7|
      Hemorrhage                           |          4           4     4                                             |      5  3.8|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Anterior Chamber, Hemorrhage         |                                                                          |      1  3.0|
      Cornea, Inflammation, Acute          |                                                                          |      1  4.0|
      Posterior Chamber, Synechia          |          4                                                               |      2  3.5|
      Retina, Degeneration                 |    4     4           4     4                                             |     12  4.0|
      Sclera, Mineralization               |                            2                                             |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Congestion                           |                2                                                         |      1  2.0|
      Cyst                                 |                                                                          |      1     |
      Infarct                              |                                                                          |      1  4.0|
      Nephropathy, Chronic                 | 3  4  3  4  4     4  3  4  3                                             |     49  3.0|
      Cortex, Cyst                         |                                                                          |      1     |
      Renal Tubule, Pigmentation           | 3  2  2  2  1     2  2  1  2                                             |     42  1.7|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   3        |
      Calculus Micro Observation Only      |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  A  +  +  +  +                                             |  49        |
      Calculus Micro Observation Only      |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 0| 4| 6| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 7| 4| 0| 3| 1| 9| 3| 3| 3| 6| 6| 6| 6| 6| 4| 0| 3| 3| 3| 0| 0| 0| 3| 3|             
                                           | 8| 7| 4| 0| 4| 3| 5| 4| 4| 4| 2| 2| 2| 2| 2| 0| 8| 4| 4| 4| 3| 6| 1| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  A  +  +  +  +|             
      Parasite Metazoan                    |             X                                                            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                      3   |             
      Metaplasia, Osseous                  |                                                                      3   |             
      Parasite Metazoan                    |                      X                                            X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  M  +  +  +  +  +|             
      Parasite Metazoan                    |             X                                         X                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  I  +  +  M  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |          X              X                    X           X        X  X  X|             
      Clear Cell Focus                     |                                                                          |             
      Developmental Malformation           |       X        X        X                                            X   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Necrosis                             |    2  2                                      2  2                        |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Bile Duct, Hyperplasia               |    2  2  2  2  2     2  2  2                 2  3  2  2  2  1  3  2  2  2|             
      Portal, Inflammation, Chronic        |    2  2  2  2  2  2  2  2  2                 2  2  2  2  2     3  2  2  2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                       +  +        +      |             
      Arteriole, Inflammation, Chronic     |                                                                          |             
      Fat, Necrosis                        |                                                       4  4        4      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Acinus, Atrophy                      |    3     2  2     2  1  3                       3  2     2     3         |             
      Acinus, Hyperplasia                  |                         3                                               2|             
      Artery, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |    2                                               3                     |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Mineralization                       |                                                    3                     |             
      Mucosa, Dilatation                   |                2     2     2                    2  2     2        2  2  2|             
      Mucosa, Erosion                      |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 0| 4| 6| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 7| 4| 0| 3| 1| 9| 3| 3| 3| 6| 6| 6| 6| 6| 4| 0| 3| 3| 3| 0| 0| 0| 3| 3|             
                                           | 8| 7| 4| 0| 4| 3| 5| 4| 4| 4| 2| 2| 2| 2| 2| 0| 8| 4| 4| 4| 3| 6| 1| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 2  2  1  2  3     3  3  2  2                 2  3  3  2  3        2  2  2|             
      Mineralization                       |                                                                          |             
      Atrium Left, Thrombosis              |                                                                          |             
      Atrium Right, Thrombosis             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |    2     2     2           2                       2     2  1  2  2      |             
      Hyperplasia                          |       2              2                                            2  2  2|             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2        3              1                 2  2     1           2     2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         2                                                |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy                          |          2                                                               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                X                                                         |             
      Pars Distalis, Hyperplasia           |       2        2     2                             1           2        2|             
      Pars Intermedia, Cyst                |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 | X                                                                        |             
      C-Cell, Hyperplasia                  |    2                 2                             2                 2   |             
      Follicle, Ectasia                    |          2        2                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Inflammation, Chronic                |          2        2                                      2     2  3  2  2|             
      Inflammation, Chronic Active         |       2     2        2     4                    4  2  3                  |             
      Duct, Ectasia                        | 4                                                                        |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |    1                                                        4            |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |       2  4  3  3  2  2     3                 2  2  2  2  2     3  2     3|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 0| 4| 6| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 7| 4| 0| 3| 1| 9| 3| 3| 3| 6| 6| 6| 6| 6| 4| 0| 3| 3| 3| 0| 0| 0| 3| 3|             
                                           | 8| 7| 4| 0| 4| 3| 5| 4| 4| 4| 2| 2| 2| 2| 2| 0| 8| 4| 4| 4| 3| 6| 1| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                3                                                         |             
      Granuloma Sperm                      |                                                                          |             
      Necrosis                             |                                                       4                  |             
      Artery, Inflammation, Chronic        |          2                 2                                             |             
      Interstitial Cell, Hyperplasia       |    2     1     1                                            3            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +                                                                     |             
      Atypia Cellular                      |    X                                                                     |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Congestion              |                         2                    2                           |             
      Mediastinal, Hyperplasia, Lymphoid   |             3                                                            |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |          2                                                               |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                                                          |             
      Mediastinal, Pigmentation            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                              3                           |             
      Cyst                                 |          X                                      X  X  X                  |             
      Hyperplasia, Lymphoid                |       2  2  2        2  2  2                       2  2           3  2  3|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                              2                           |             
      Cyst                                 |                                                                      X   |             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
      Inflammation, Acute                  |                                              4                           |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                            2                 3  3                       2|             
      Hematopoietic Cell Proliferation     | 1  4     2  1  1     1  2  1                       1  1  2        1  2  1|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
      Pigmentation                         |    2  2  2  2        2  2  2                    2     2  2        2  2   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  M                 M  M  +  M  +  +  +  +  +  M|             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +                 +  +  +  M  +  +  +  +  M  +|             
      Acinus, Ectasia                      |       2  3     2           3                       2              2      |             
      Duct, Ectasia                        |                                                             2            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 0| 4| 6| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 7| 4| 0| 3| 1| 9| 3| 3| 3| 6| 6| 6| 6| 6| 4| 0| 3| 3| 3| 0| 0| 0| 3| 3|             
                                           | 8| 7| 4| 0| 4| 3| 5| 4| 4| 4| 2| 2| 2| 2| 2| 0| 8| 4| 4| 4| 3| 6| 1| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Abscess                              |                                                                          |             
      Alopecia                             |                                                                          |             
      Cyst Epithelial Inclusion            |          X                                                               |             
      Inflammation, Chronic                |                                                                      3   |             
      Inflammation, Chronic Active         |                                                       2                  |             
      Ulcer                                | 4                                                                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Compression                          |          2                                                        2      |             
      Hemorrhage                           |                4                                               4         |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 2                                                                        |             
      Hemorrhage                           |                                                                      2   |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |             2                                         2           2     2|             
      Arteriole, Mineralization            |       2  2  2  2        1  2                 2  2  2  2  2  2  2  2      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Lumen, Hemorrhage                    |                1     1  2                          2     2           2   |             
      Mucosa, Inflammation, Acute          |          1  3                                2                       3   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                          2     2         |             
      Olfactory Epithelium, Degeneration   |    1  2  2     2  2  2  2  1                 2  2  1  2  2     2  1     1|             
      Respiratory Epithelium, Degeneration |          1     2                                                         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +     +  +                                                            |             
      Cataract                             |    4     4  4                                                            |             
      Hemorrhage                           |                                                                          |             
      Retina, Degeneration                 |    4     4  4                                                            |             
      Sclera, Mineralization               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 0| 4| 6| 7| 7| 6| 6| 7| 7| 7| 4| 4| 4| 4| 4| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 7| 4| 0| 3| 1| 9| 3| 3| 3| 6| 6| 6| 6| 6| 4| 0| 3| 3| 3| 0| 0| 0| 3| 3|             
                                           | 8| 7| 4| 0| 4| 3| 5| 4| 4| 4| 2| 2| 2| 2| 2| 0| 8| 4| 4| 4| 3| 6| 1| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 |    2  4  4  3  2  2  4  2  4                 2  3  3  4  2  2  3  4  2  4|             
      Pelvis, Dilatation                   |                                                                          |             
      Renal Tubule, Pigmentation           |    1  2  2  2  2  2  2  2  2                 2  2  2  2  2     2  2  2  2|             
                                            __________________________________________________________________________|             
   Urethra                                 | +              +                                                         |             
      Calculus Micro Observation Only      | X              X                                                         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                 +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |          4                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 6| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 2| 7| 3| 3| 7| 2| 3| 3| 1| 1| 8| 3| 3| 3| 1| 5| 6| 3| 4| 9| 1| 3| 3|             
                                           | 9| 2| 4| 5| 4| 7| 7| 2| 4| 4| 6| 8| 3| 4| 4| 5| 7| 8| 7| 4| 6| 2| 0| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                        X                 X              X|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Parasite Metazoan                    |                                                                   X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    X                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |       X     X           X  X     X     X  X  X                    X  X  X|             
      Clear Cell Focus                     |                                        X                                 |             
      Developmental Malformation           |                   X  X  X     X        X                                 |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Necrosis                             |                3              2     2                                    |             
      Vacuolization Cytoplasmic            |                               1                                          |             
      Bile Duct, Hyperplasia               | 1  2  2  2  2  2  2  2  2  2     1  3  2  2  2  3  2  2  2  2  2  2     2|             
      Portal, Inflammation, Chronic        |    2  2  2  2  2  2  2  2  2     1  3  2  2  2  2  2  3  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Mesentery                               |       +        +           +                                +        +   |             
      Arteriole, Inflammation, Chronic     |                                                                      3   |             
      Fat, Necrosis                        |       4                    4                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2                                                                        |             
      Acinus, Atrophy                      |       2              3  2                 2  2  2  2     3     3  1  2   |             
      Acinus, Hyperplasia                  |                                                    3     2               |             
      Artery, Inflammation, Chronic        |                                           2              3               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                2                                         3               |             
      Ulcer                                |                      4                                                   |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                               2                                          |             
      Mineralization                       |                                                          3               |             
      Mucosa, Dilatation                   | 2  2        2  2     2  2  2     2     2  2     2        2     2  2  2  2|             
      Mucosa, Erosion                      |                               1                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 6| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 2| 7| 3| 3| 7| 2| 3| 3| 1| 1| 8| 3| 3| 3| 1| 5| 6| 3| 4| 9| 1| 3| 3|             
                                           | 9| 2| 4| 5| 4| 7| 7| 2| 4| 4| 6| 8| 3| 4| 4| 5| 7| 8| 7| 4| 6| 2| 0| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy, Chronic              | 2  2  2  3  2  1  3     3  4  3  2  1  3  3  2  3  3  2  3  3  2  3  3  3|             
      Mineralization                       |                            2                                             |             
      Atrium Left, Thrombosis              |                2                                                         |             
      Atrium Right, Thrombosis             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |    2                          2                 1  1  2  2           2  2|             
      Hyperplasia                          |          2     2        2           2                    2           2  2|             
      Pigmentation                         |             2                                                            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             1                 2           2        2  2  2  2  1  2  2  3|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Hyperplasia                          |                                                                         2|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                         X              X                                 |             
      Pars Distalis, Hyperplasia           |             2     2        1           2  2        2              2      |             
      Pars Intermedia, Cyst                |                                                       X                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |                2     2     2     1                 1  1           2  2   |             
      Follicle, Ectasia                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              | 4                                                                        |             
      Inflammation, Chronic                |    2  2           2              3              3  2  3              2  2|             
      Inflammation, Chronic Active         | 2           3  2     2  2  3        3  3  3  3              3  2  3      |             
      Duct, Ectasia                        |          3                                         3                    3|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                         2              2                                 |             
      Inflammation, Chronic Active         | 3  3  3  4     3  3  2     3  3  3  2     3  3  2  3  3  3  4  2  2  4  4|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 6| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 2| 7| 3| 3| 7| 2| 3| 3| 1| 1| 8| 3| 3| 3| 1| 5| 6| 3| 4| 9| 1| 3| 3|             
                                           | 9| 2| 4| 5| 4| 7| 7| 2| 4| 4| 6| 8| 3| 4| 4| 5| 7| 8| 7| 4| 6| 2| 0| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    2           2                    3                       3     3      |             
      Granuloma Sperm                      |                                     2                                    |             
      Necrosis                             |                                                                          |             
      Artery, Inflammation, Chronic        |    2                                                                     |             
      Interstitial Cell, Hyperplasia       | 2  1     1     2                    1           1  1              2     1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +     +                                            +                  |             
      Atypia Cellular                      |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                    3                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Congestion              |       2                    3                                             |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                                             2            |             
      Mediastinal, Pigmentation            |                2                                   2                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |    X                                   X                                 |             
      Hyperplasia, Lymphoid                | 2     2  2  2  2        3  2  2  2     2  2  2  2  2     2  3        2  2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                              4                           |             
      Cyst                                 |                                                                          |             
      Infiltration Cellular, Plasma Cell   |                                           2                              |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                   4      |             
      Hematopoietic Cell Proliferation     | 2     2  3  2  3        2  2  4        2  1              1  3        2  1|             
      Hyperplasia, Lymphoid                |          3     2                                                         |             
      Hyperplasia, Reticulum Cell          |                                                                          |             
      Pigmentation                         | 2           2     2        2     3     2  2  3     2              3     2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                         2                                                |             
      Cyst                                 |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  +  +  M  +  M  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Acinus, Ectasia                      | 3                 2                 2        3        2  2  2  3         |             
      Duct, Ectasia                        |    3                                                              2      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 6| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 2| 7| 3| 3| 7| 2| 3| 3| 1| 1| 8| 3| 3| 3| 1| 5| 6| 3| 4| 9| 1| 3| 3|             
                                           | 9| 2| 4| 5| 4| 7| 7| 2| 4| 4| 6| 8| 3| 4| 4| 5| 7| 8| 7| 4| 6| 2| 0| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Abscess                              |          4                                                               |             
      Alopecia                             |                                                          2               |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Inflammation, Chronic                |    2                                                                     |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |       3                                                                  |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          | 2                                3           3                           |             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                 3                        |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                         2                    2                           |             
      Hemorrhage                           |                   3              2                                       |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Arteriole, Mineralization            | 2  2     2  2  2              2  2  2  2  1     2  2     2     2  2  2  2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Hemorrhage                    | 1     3                          2     1  1                              |             
      Mucosa, Inflammation, Acute          |                                     2                    4  3            |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           | 2              2  2        1     2                 2              2  2  2|             
      Olfactory Epithelium, Degeneration   | 2        2     2     2        2  2  2  2        2     2     2  2  2     2|             
      Respiratory Epithelium, Degeneration | 1                                2                                      2|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                               +                    +                     |             
                                            __________________________________________________________________________|             
   Eye                                     |    +  +     +           +     +                       +           +      |             
      Cataract                             |    4  4     4           4     2                       4           4      |             
      Hemorrhage                           |                               2                                   3      |             
      Retina, Degeneration                 |    4  4     4           4     4                       4           4      |             
      Sclera, Mineralization               |       4                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 6| 7| 6| 6| 7| 7| 7| 6| 6| 6| 7| 7| 5| 6| 6| 6| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 8| 3| 2| 7| 3| 3| 7| 2| 3| 3| 1| 1| 8| 3| 3| 3| 1| 5| 6| 3| 4| 9| 1| 3| 3|             
                                           | 9| 2| 4| 5| 4| 7| 7| 2| 4| 4| 6| 8| 3| 4| 4| 5| 7| 8| 7| 4| 6| 2| 0| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    2.5%                                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 | 2  4  2  2  4  2  4  2  4  4  3  4  2  4  4  2  2  3  3  4  4  2  4  3  4|             
      Pelvis, Dilatation                   |                                                             4            |             
      Renal Tubule, Pigmentation           | 2  2  2  2  2  3  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Calculus Micro Observation Only      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 6| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 3| 3| 8| 0| 3|                                            |            |
                                           | 2| 2| 2| 2| 2| 8| 5| 7| 1| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                +  +  +  +  +                                             |  49        |
      Parasite Metazoan                    |                      X                                                   |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                +  +  +  +  +                                             |  50        |
      Diverticulum                         |                                                                          |      1  3.0|
      Metaplasia, Osseous                  |                                                                          |      1  3.0|
      Parasite Metazoan                    |                            X                                             |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                +  +  +  +  +                                             |  49        |
      Parasite Metazoan                    |                X        X                                                |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                +  +  +  +  +                                             |  47        |
      Inflammation, Chronic                |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                +  +  +  +  +                                             |  50        |
      Basophilic Focus                     |                      X  X  X                                             |     21     |
      Clear Cell Focus                     |                                                                          |      1     |
      Developmental Malformation           |                                                                          |      9     |
      Hematopoietic Cell Proliferation     |                2                                                         |      1  2.0|
      Necrosis                             |                            1                                             |      8  2.0|
      Vacuolization Cytoplasmic            |                   2                                                      |      2  1.5|
      Bile Duct, Hyperplasia               |                      2  2  2                                             |     44  2.0|
      Portal, Inflammation, Chronic        |                1     2  2  2                                             |     45  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +           +                                             |  10        |
      Arteriole, Inflammation, Chronic     |                                                                          |      1  3.0|
      Fat, Necrosis                        |                3           4                                             |      7  3.9|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                +  +  +  +  +                                             |  50        |
      Atrophy                              |                                                                          |      1  2.0|
      Acinus, Atrophy                      |                      2                                                   |     22  2.2|
      Acinus, Hyperplasia                  |                                                                          |      4  2.5|
      Artery, Inflammation, Chronic        |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                +  +  +  +  +                                             |  50        |
      Inflammation, Chronic Active         |                   3                                                      |      1  3.0|
      Mineralization                       |                                                                          |      4  2.5|
      Ulcer                                |                                                                          |      1  4.0|
      Epithelium, Hyperplasia              |                   2                                                      |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  84                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 6| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 3| 3| 8| 0| 3|                                            |            |
                                           | 2| 2| 2| 2| 2| 8| 5| 7| 1| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                +  +  +  +  +                                             |  50        |
      Dilatation                           |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      2  3.0|
      Mucosa, Dilatation                   |                2     2  2  2                                             |     29  2.0|
      Mucosa, Erosion                      |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                +  +  +  +  +                                             |  50        |
      Cardiomyopathy, Chronic              |                2  2  3  3  3                                             |     46  2.5|
      Mineralization                       |                                                                          |      1  2.0|
      Atrium Left, Thrombosis              |                                                                          |      1  2.0|
      Atrium Right, Thrombosis             |                X                                                         |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                +  +  +  +  +                                             |  50        |
      Degeneration, Fatty                  |                2  2  3  2                                                |     21  1.9|
      Hyperplasia                          |                            2                                             |     13  2.0|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                +  +  +  +  +                                             |  50        |
      Hyperplasia                          |                3     2     2                                             |     22  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                +  +  +  +  +                                             |  48        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                +  +  +  +  +                                             |  47        |
      Hypertrophy                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                +  +  +  +  +                                             |  49        |
      Pars Distalis, Cyst                  |                      X  X                                                |      5     |
      Pars Distalis, Hyperplasia           |                            2                                             |     14  1.9|
      Pars Intermedia, Cyst                |                X                                                         |      2     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                +  +  +  +  +                                             |  50        |
      Ultimobranchial Cyst                 |                                                                          |      1     |
      C-Cell, Hyperplasia                  |                                                                          |     12  1.8|
      Follicle, Ectasia                    |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                +  +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  85                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 6| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 3| 3| 8| 0| 3|                                            |            |
                                           | 2| 2| 2| 2| 2| 8| 5| 7| 1| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                +  +  +  +  +                                             |  50        |
      Abscess                              |                                                                          |      1  4.0|
      Inflammation, Chronic                |                1        2                                                |     18  2.2|
      Inflammation, Chronic Active         |                      4                                                   |     21  2.7|
      Duct, Ectasia                        |                                                                          |      4  3.3|
                                            __________________________________________________________________________|____________|
   Prostate                                |                +  +  +  +  +                                             |  50        |
      Inflammation, Acute                  |                                                                          |      2  2.5|
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Inflammation, Chronic Active         |                4  4     2  3                                             |     41  2.8|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  |                +  +  +  +  +                                             |  50        |
      Atrophy                              |                   3                                                      |      7  2.7|
      Granuloma Sperm                      |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  4.0|
      Artery, Inflammation, Chronic        |                                                                          |      3  2.0|
      Interstitial Cell, Hyperplasia       |                1  1                                                      |     15  1.4|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   4        |
      Atypia Cellular                      |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                +  +  +  +  +                                             |  50        |
      Hemorrhage                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +  +  +  +  +                                             |  50        |
      Mediastinal, Congestion              |                                                                          |      4  2.3|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  3.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  2.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                                                                          |      1  2.0|
      Mediastinal, Pigmentation            |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                +  +  +  +  +                                             |  50        |
      Congestion                           |                                                                          |      1  3.0|
      Cyst                                 |                                                                          |      6     |
      Hyperplasia, Lymphoid                |                      2     2                                             |     31  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                +  +  +  +  +                                             |  50        |
      Congestion                           |                         2                                                |      3  2.7|
      Cyst                                 |                                                                          |      1     |
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  86                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 6| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 3| 3| 8| 0| 3|                                            |            |
                                           | 2| 2| 2| 2| 2| 8| 5| 7| 1| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                +  +  +  +  +                                             |  50        |
      Fibrosis                             |                                                                          |      5  2.8|
      Hematopoietic Cell Proliferation     |                3  3        2                                             |     31  1.9|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
      Hyperplasia, Reticulum Cell          |                      2                                                   |      1  2.0|
      Pigmentation                         |                   3     2  2                                             |     26  2.2|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                +  +  +  M  M                                             |  40        |
      Congestion                           |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                M  M  +  +  +                                             |  39        |
      Acinus, Ectasia                      |                         2                                                |     15  2.3|
      Duct, Ectasia                        |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    |                +  +  +  +  +                                             |  50        |
      Abscess                              |                                                                          |      1  4.0|
      Alopecia                             |                                                                          |      1  2.0|
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Inflammation, Chronic                |                                                                          |      2  2.5|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                +  +  +  +  +                                             |  50        |
      Hyperostosis                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                +  +  +  +  +                                             |  50        |
      Compression                          |                                                                          |      5  2.4|
      Hemorrhage                           |                                                                          |      2  4.0|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                +  +  +  +  +                                             |  50        |
      Congestion                           |                   3                                                      |      4  2.3|
      Hemorrhage                           |                            2                                             |      4  2.3|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  87                                                               
NTP Experiment-Test: 05007-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           POLYSORBATE 80                                      Date: 04/28/97  
Route: DOSED FEED                                                                                                 Time: 07:49:23  
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 6| 6| 6| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6| 3| 3| 8| 0| 3|                                            |            |
                                           | 2| 2| 2| 2| 2| 8| 5| 7| 1| 4|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    2.5%                                   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Histiocyte                      |                                                                          |      4  2.0|
      Arteriole, Mineralization            |                   2  1  2  2                                             |     35  1.9|
                                            __________________________________________________________________________|____________|
   Nose                                    |                +  +  +  +  +                                             |  50        |
      Lumen, Hemorrhage                    |                   1                                                      |     12  1.6|
      Mucosa, Inflammation, Acute          |                                                                          |      7  2.6|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                2                                                         |     12  1.9|
      Olfactory Epithelium, Degeneration   |                2  2  2  2                                                |     34  1.9|
      Respiratory Epithelium, Degeneration |                                                                          |      5  1.6|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                         +                                                |  11        |
      Cataract                             |                         4                                                |     11  3.8|
      Hemorrhage                           |                         3                                                |      3  2.7|
      Retina, Degeneration                 |                         4                                                |     11  4.0|
      Sclera, Mineralization               |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                +  +  +  +  +                                             |  50        |
      Nephropathy, Chronic                 |                2  4  2  3  4                                             |     49  3.0|
      Pelvis, Dilatation                   |                                                                          |      1  4.0|
      Renal Tubule, Pigmentation           |                1  2  2  2  2                                             |     48  2.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   2        |
      Calculus Micro Observation Only      |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                +  +  +  +  +                                             |  50        |
      Inflammation, Chronic                |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  88                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------