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https://ntp.niehs.nih.gov/go/2776

TDMS Study 05019-03 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                          CI PIGMENT RED 3


NTP Experiment-Test: 05019-03                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/03/94
Route: DOSED FEED                                                                                                 Time: 14:37:32




       Facility:  Southern Research Institute

       Chemical CAS #:  2425-85-6

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05019-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 14:37:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATD     0.6%         1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund                                          15            7            8            7                                     
    Dead                                               3            2            3            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           40           39           40                                     
    Dead                                                            1                                                               
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large                                    (50)         (10)         (12)         (50)                                   
      Wall, Inflammation, Subacute                                                            1 (2%)                                
   Intestine Large, Cecum                             (48)         (9)          (12)         (50)                                   
      Parasite Metazoan                                2 (4%)                                 2 (4%)                                
   Intestine Large, Colon                             (50)         (10)         (12)         (48)                                   
      Parasite Metazoan                                2 (4%)       2 (20%)                   8 (17%)                               
   Intestine Large, Rectum                            (50)         (10)         (12)         (50)                                   
      Parasite Metazoan                               10 (20%)      1 (10%)      1 (8%)       6 (12%)                               
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis, Focal                               1 (2%)                                                                       
      Angiectasis, Multifocal                                                    2 (4%)                                             
      Basophilic Focus                                 1 (2%)      11 (22%)     17 (34%)     11 (22%)                               
      Basophilic Focus, Multiple                      37 (74%)     29 (58%)     26 (52%)     30 (60%)                               
      Clear Cell Focus                                                                        2 (4%)                                
      Degeneration, Cystic, Focal                                   1 (2%)       2 (4%)       3 (6%)                                
      Degeneration, Cystic, Multifocal                                           1 (2%)       2 (4%)                                
      Eosinophilic Focus                               1 (2%)       7 (14%)     13 (26%)     14 (28%)                               
      Eosinophilic Focus, Multiple                                               5 (10%)      2 (4%)                                
      Granuloma, Multiple                             27 (54%)     21 (42%)     43 (86%)     44 (88%)                               
      Hepatodiaphragmatic Nodule                       4 (8%)       6 (12%)     12 (24%)      3 (6%)                                
      Mixed Cell Focus                                 4 (8%)      10 (20%)     13 (26%)      3 (6%)                                
      Mixed Cell Focus, Multiple                                    6 (12%)     17 (34%)     37 (74%)                               
      Necrosis, Focal                                  2 (4%)                                                                       
      Necrosis, Multifocal                             1 (2%)                                 1 (2%)                                
      Pigmentation, Multifocal, Cholesterol                         3 (6%)      14 (28%)     41 (82%)                               
      Regeneration                                     6 (12%)                                                                      
      Vacuolization Cytoplasmic, Diffuse               4 (8%)       1 (2%)                    1 (2%)                                
      Vacuolization Cytoplasmic, Multifocal                                      1 (2%)                                             
      Biliary Tract, Dilatation, Focal                                           2 (4%)       4 (8%)                                
      Biliary Tract, Proliferation                    18 (36%)     12 (24%)     18 (36%)     29 (58%)                               
      Centrilobular, Necrosis                          1 (2%)       1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05019-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 14:37:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATD     0.6%         1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Mesentery                                          (6)          (6)          (10)         (4)                                    
      Inflammation, Chronic                                                                   1 (25%)                               
      Inflammation, Granulomatous                                   1 (17%)                                                         
      Fat, Necrosis, Focal                             4 (67%)      6 (100%)    10 (100%)     3 (75%)                               
   Pancreas                                           (50)         (50)         (50)         (49)                                   
      Basophilic Focus                                 1 (2%)       1 (2%)       2 (4%)       2 (4%)                                
      Acinus, Atrophy, Multifocal                     22 (44%)     33 (66%)     40 (80%)     36 (73%)                               
      Acinus, Hyperplasia, Focal                       2 (4%)                                                                       
      Acinus, Hyperplasia, Multifocal                  1 (2%)                                                                       
      Artery, Hypertrophy                                                        1 (2%)                                             
      Artery, Inflammation, Subacute                                1 (2%)                                                          
      Duct, Hyperplasia                                                                       2 (4%)                                
   Pharynx                                                         (2)          (1)                                                 
      Hyperplasia                                                   1 (50%)                                                         
   Salivary Glands                                    (50)         (10)         (12)         (50)                                   
      Acinus, Atrophy, Focal                           4 (8%)                                 2 (4%)                                
      Acinus, Atrophy, Multifocal                      1 (2%)                    1 (8%)       6 (12%)                               
   Stomach, Forestomach                               (50)         (9)          (12)         (50)                                   
      Hyperplasia                                                                2 (17%)      1 (2%)                                
      Inflammation, Subacute                                                     2 (17%)      1 (2%)                                
      Mineralization                                   1 (2%)                                                                       
      Perforation                                                                1 (8%)                                             
      Ulcer                                                                      1 (8%)       1 (2%)                                
   Stomach, Glandular                                 (50)         (9)          (12)         (50)                                   
      Erosion                                                                    1 (8%)                                             
      Mineralization                                   1 (2%)                                 4 (8%)                                
   Tooth                                                           (1)                                                              
      Dysplasia                                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (10)         (12)         (50)                                   
      Cardiomyopathy                                  33 (66%)      6 (60%)      7 (58%)     34 (68%)                               
      Inflammation, Focal, Subacute                    1 (2%)                                 2 (4%)                                
      Atrium, Thrombosis                                            1 (10%)                   1 (2%)                                
      Valve, Inflammation, Subacute                                                           1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (16)         (13)         (50)                                   
      Angiectasis                                      1 (2%)       1 (6%)       1 (8%)       1 (2%)                                
      Congestion                                       1 (2%)                                                                       
      Degeneration, Fatty, Focal                       8 (16%)      1 (6%)       6 (46%)     15 (30%)                               
      Degeneration, Fatty, Multifocal                               3 (19%)      1 (8%)                                             
      Hyperplasia, Focal                              18 (36%)      3 (19%)      2 (15%)     20 (40%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05019-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 14:37:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATD     0.6%         1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia, Multifocal                                                                 1 (2%)                                
      Hypertrophy, Focal                               4 (8%)                    1 (8%)       6 (12%)                               
      Inflammation, Granulomatous, Multifocal          1 (2%)                                                                       
      Pigmentation, Multifocal, Cholesterol                                                   1 (2%)                                
      Capsule, Accessory Adrenal Cortical Nodule       4 (8%)       2 (13%)                   4 (8%)                                
   Adrenal Gland, Medulla                             (49)         (16)         (13)         (50)                                   
      Hyperplasia, Focal                              10 (20%)      2 (13%)      2 (15%)     11 (22%)                               
      Hyperplasia, Multifocal                          1 (2%)                                                                       
   Islets, Pancreatic                                 (49)         (50)         (50)         (49)                                   
      Hyperplasia                                      1 (2%)                                                                       
   Parathyroid Gland                                  (50)         (9)          (12)         (50)                                   
      Hyperplasia                                      1 (2%)                                 1 (2%)                                
   Pituitary Gland                                    (50)         (22)         (20)         (50)                                   
      Cyst                                                          1 (5%)       1 (5%)                                             
      Pars Distalis, Angiectasis                      35 (70%)     15 (68%)     12 (60%)     26 (52%)                               
      Pars Distalis, Cyst                             26 (52%)     10 (45%)      6 (30%)     19 (38%)                               
      Pars Distalis, Hemorrhage                                     2 (9%)                                                          
      Pars Distalis, Hyperplasia, Focal               15 (30%)      5 (23%)      3 (15%)     14 (28%)                               
      Pars Distalis, Pigmentation, Hemosiderin        24 (48%)      4 (18%)      4 (20%)      9 (18%)                               
   Thyroid Gland                                      (50)         (12)         (13)         (50)                                   
      Pigmentation, Focal, Cholesterol                                                        1 (2%)                                
      Ultimobranchial Cyst                             1 (2%)                    1 (8%)       1 (2%)                                
      C-Cell, Hyperplasia, Focal                       8 (16%)                   2 (15%)     10 (20%)                               
      Follicle, Cyst                                                                          3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (47)         (14)         (14)         (50)                                   
      Hyperplasia                                      7 (15%)      2 (14%)      1 (7%)       3 (6%)                                
      Inflammation, Subacute                           9 (19%)      3 (21%)                   2 (4%)                                
      Duct, Cyst                                      14 (30%)      1 (7%)       2 (14%)      4 (8%)                                
   Ovary                                              (50)         (14)         (14)         (50)                                   
      Cyst                                             5 (10%)      3 (21%)      5 (36%)      8 (16%)                               
      Inflammation, Granulomatous, Multifocal          1 (2%)                                                                       
   Uterus                                             (50)         (23)         (28)         (50)                                   
      Dilatation                                       3 (6%)       2 (9%)       2 (7%)       9 (18%)                               
      Hemorrhage                                                    1 (4%)                                                          
      Cervix, Abscess                                  5 (10%)      5 (22%)     12 (43%)      6 (12%)                               
      Cervix, Abscess, Multiple                                     1 (4%)                                                          
      Cervix, Cyst                                     5 (10%)      5 (22%)     13 (46%)      6 (12%)                               
      Cervix, Cyst, Multiple                                        1 (4%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05019-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 14:37:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATD     0.6%         1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Endometrium, Hyperplasia, Cystic                 1 (2%)                                 3 (6%)                                
      Mucosa, Cyst                                     3 (6%)                    1 (4%)       6 (12%)                               
      Wall, Cervix, Hypertrophy                        1 (2%)                                                                       
   Vagina                                             (7)                       (5)          (1)                                    
      Wall, Hypertrophy                                1 (14%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (10)         (12)         (50)                                   
      Hyperplasia                                      8 (16%)      1 (10%)      1 (8%)       9 (18%)                               
      Infiltration Cellular, Histiocyte                2 (4%)                                 4 (8%)                                
      Myelofibrosis                                    2 (4%)                                 2 (4%)                                
      Pigmentation, Multifocal, Cholesterol            2 (4%)                                 4 (8%)                                
   Lymph Node                                         (50)         (50)         (50)         (50)                                   
      Inguinal, Hyperplasia, Lymphoid                  1 (2%)                                                                       
      Mediastinal, Congestion                          2 (4%)       2 (4%)       7 (14%)      4 (8%)                                
      Mediastinal, Ectasia                                          3 (6%)       4 (8%)       3 (6%)                                
      Mesenteric, Ectasia                                                        2 (4%)       3 (6%)                                
      Mesenteric, Fibrosis, Focal                                                1 (2%)                                             
      Mesenteric, Hyperplasia, Macrophage,                                                                                          
          Multifocal                                  49 (98%)     48 (96%)     48 (96%)     48 (96%)                               
      Mesenteric, Necrosis, Focal                                                3 (6%)       1 (2%)                                
      Mesenteric, Necrosis, Multifocal                                           1 (2%)       4 (8%)                                
      Mesenteric, Pigmentation, Multifocal,                                                                                         
          Cholesterol                                 49 (98%)     45 (90%)     47 (94%)     48 (96%)                               
      Pancreatic, Ectasia                              2 (4%)                                 2 (4%)                                
      Pancreatic, Hyperplasia, Macrophage,                                                                                          
          Multifocal                                                                          2 (4%)                                
      Pancreatic, Pigmentation, Multifocal,                                                                                         
          Cholesterol                                                                         2 (4%)                                
   Lymph Node, Mandibular                             (50)         (50)         (50)         (49)                                   
      Congestion                                                    1 (2%)       1 (2%)       1 (2%)                                
      Ectasia                                         21 (42%)     17 (34%)     18 (36%)     21 (43%)                               
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Atrophy                                                       1 (2%)       1 (2%)       1 (2%)                                
      Fibrosis, Focal                                  2 (4%)                                 3 (6%)                                
      Hematopoietic Cell Proliferation                 3 (6%)       1 (2%)       1 (2%)       1 (2%)                                
      Hyperplasia, Focal                               1 (2%)                                                                       
   Thymus                                             (49)         (11)         (12)         (50)                                   
      Atrophy                                                                                 1 (2%)                                
      Cyst                                             3 (6%)       1 (9%)                    3 (6%)                                
      Inflammation, Subacute                                        1 (9%)                                                          
      Artery, Mediastinum, Inflammation, Subacute                                             1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05019-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 14:37:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATD     0.6%         1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (49)         (50)                                   
      Duct, Cyst                                       1 (2%)                                                                       
   Skin                                               (50)         (26)         (33)         (50)                                   
      Inflammation, Acute, Focal, Suppurative                                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (15)         (16)         (50)                                   
      Fibrous Osteodystrophy                           1 (2%)                                                                       
      Inflammation, Chronic                                         1 (7%)                                                          
      Cranium, Osteopetrosis                           5 (10%)                   3 (19%)      7 (14%)                               
      Femur, Osteopetrosis                             4 (8%)       3 (20%)      3 (19%)     11 (22%)                               
      Turbinate, Osteopetrosis                         2 (4%)       2 (13%)      1 (6%)       9 (18%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (10)         (13)         (50)                                   
      Compression                                      4 (8%)       1 (10%)      1 (8%)       3 (6%)                                
      Hemorrhage, Multifocal                                        1 (10%)                   1 (2%)                                
      Hydrocephalus                                    1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                       1 (2%)                    1 (2%)                                             
      Granuloma, Multiple                              1 (2%)                                                                       
      Hemorrhage, Multifocal                                                     1 (2%)                                             
      Infiltration Cellular, Diffuse, Histiocyte       1 (2%)                                 1 (2%)                                
      Pigmentation, Hemosiderin, Multifocal                         1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia, Focal                                                 3 (6%)                                
      Mediastinum, Inflammation, Chronic                                                      1 (2%)                                
      Pleura, Congestion, Multifocal                                                          3 (6%)                                
      Pleura, Fibrosis, Focal                          1 (2%)                                                                       
   Nose                                               (50)         (10)         (12)         (50)                                   
      Foreign Body                                     2 (4%)                                 5 (10%)                               
      Fungus                                           2 (4%)                                 4 (8%)                                
      Inflammation, Acute, Suppurative                 2 (4%)                                 6 (12%)                               
      Nasolacrimal Duct, Foreign Body                                                         1 (2%)                                
      Nasolacrimal Duct, Inflammation, Subacute       19 (38%)                   1 (8%)      21 (42%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05019-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 14:37:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   UNTREATD     0.6%         1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (17)         (12)         (13)         (10)                                   
      Cataract                                        17 (100%)    12 (100%)    13 (100%)    10 (100%)                              
      Anterior Chamber, Hemorrhage                                  2 (17%)                   1 (10%)                               
      Posterior Chamber, Hemorrhage                                 1 (8%)                                                          
      Retina, Degeneration                            17 (100%)    11 (92%)     13 (100%)    10 (100%)                              
   Harderian Gland                                                 (1)                                                              
      Hyperplasia                                                   1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (49)                                   
      Fibrosis, Focal                                                                         1 (2%)                                
      Hydronephrosis                                   1 (2%)                                 1 (2%)                                
      Inflammation, Subacute                                        1 (2%)       1 (2%)                                             
      Metaplasia, Focal, Osseous                                                              1 (2%)                                
      Mineralization, Multifocal                                                              1 (2%)                                
      Nephropathy, Chronic                            49 (98%)     49 (98%)     50 (100%)    48 (98%)                               
      Artery, Inflammation, Subacute                                             1 (2%)                                             
      Cortex, Cyst                                     1 (2%)                                                                       
      Papilla, Necrosis                                                                       1 (2%)                                
      Papilla, Transitional Epithelium, Hyperplasia    1 (2%)       5 (10%)      4 (8%)      12 (24%)                               
      Pelvis, Transitional Epithelium, Hyperplasia                               1 (2%)       2 (4%)                                
      Renal Tubule, Pigmentation, Hemosiderin,                                                                                      
           Multifocal                                  2 (4%)                                                                       
   Urinary Bladder                                    (50)         (10)         (12)         (50)                                   
      Calculus Micro Observation Only                                                         1 (2%)                                
      Hemorrhage, Multifocal                                                                  1 (2%)                                
      Mucosa, Hyperplasia                                                                     2 (4%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05019-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 14:37:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     0.6%         1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10            9            9            9                                     
  Early Deaths                                                                                                                      
    Moribund                                          17            7           16           26                                     
    Dead                                               5            4            7            5                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           40           28           20                                     
  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (9)          (22)         (50)                                   
      Inflammation, Subacute                                                                  1 (2%)                                
   Intestine Large, Cecum                             (49)         (10)         (19)         (50)                                   
      Parasite Metazoan                                2 (4%)                    1 (5%)       3 (6%)                                
      Artery, Inflammation, Subacute                                             1 (5%)                                             
      Artery, Necrosis, Fibrinoid                                                1 (5%)                                             
   Intestine Large, Colon                             (50)         (10)         (22)         (50)                                   
      Parasite Metazoan                                2 (4%)                    1 (5%)       6 (12%)                               
      Lymphoid Tissue, Inflammation, Subacute                                                 1 (2%)                                
      Lymphoid Tissue, Mineralization                                                         1 (2%)                                
      Wall, Mineralization                                                                    1 (2%)                                
   Intestine Large, Rectum                            (50)         (10)         (22)         (49)                                   
      Parasite Metazoan                                9 (18%)                                4 (8%)                                
      Wall, Mineralization                                                                    1 (2%)                                
   Intestine Small, Ileum                             (50)         (9)          (19)         (49)                                   
      Lymphoid Tissue, Inflammation, Subacute                                                 1 (2%)                                
      Lymphoid Tissue, Mineralization                                                         1 (2%)                                
   Intestine Small, Jejunum                           (50)         (10)         (20)         (49)                                   
      Inflammation, Multifocal, Subacute                                                      1 (2%)                                
      Necrosis, Multifocal                                                                    1 (2%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis, Focal                               5 (10%)     10 (20%)      4 (8%)                                             
      Angiectasis, Multifocal                          3 (6%)      20 (40%)     21 (42%)     29 (58%)                               
      Basophilic Focus                                18 (36%)     14 (28%)     12 (24%)      7 (14%)                               
      Basophilic Focus, Multiple                       3 (6%)       2 (4%)       1 (2%)                                             
      Clear Cell Focus                                 2 (4%)       3 (6%)       2 (4%)       2 (4%)                                
      Congestion                                                                 1 (2%)       2 (4%)                                
      Cyst                                                                       1 (2%)       1 (2%)                                
      Degeneration, Cystic, Focal                      7 (14%)      3 (6%)       5 (10%)                                            
      Degeneration, Cystic, Multifocal                 2 (4%)      33 (66%)     35 (70%)     36 (72%)                               
      Eosinophilic Focus                               5 (10%)     16 (32%)     14 (28%)      4 (8%)                                
      Eosinophilic Focus, Multiple                     1 (2%)      21 (42%)     22 (44%)     37 (74%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05019-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 14:37:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     0.6%         1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fibrosis                                         1 (2%)                    1 (2%)                                             
      Granuloma                                                                  1 (2%)                                             
      Granuloma, Multiple                             20 (40%)     31 (62%)     27 (54%)     27 (54%)                               
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                       2 (4%)       5 (10%)      5 (10%)      5 (10%)                               
      Hepatodiaphragmatic Nodule, Multiple, Two                                  1 (2%)                                             
      Inflammation, Subacute                                        1 (2%)       1 (2%)                                             
      Mixed Cell Focus                                 2 (4%)      14 (28%)     15 (30%)      7 (14%)                               
      Mixed Cell Focus, Multiple                                   10 (20%)      6 (12%)      8 (16%)                               
      Necrosis, Focal                                               1 (2%)                    1 (2%)                                
      Necrosis, Multifocal                                          1 (2%)       4 (8%)                                             
      Pigmentation, Hemosiderin                        1 (2%)       1 (2%)       1 (2%)                                             
      Pigmentation, Multifocal, Cholesterol            1 (2%)                                 1 (2%)                                
      Regeneration                                    16 (32%)                   1 (2%)                                             
      Thrombosis                                       1 (2%)                                                                       
      Vacuolization Cytoplasmic, Diffuse                            1 (2%)                    1 (2%)                                
      Biliary Tract, Cyst                                                                     2 (4%)                                
      Biliary Tract, Proliferation                    49 (98%)     45 (90%)     49 (98%)     50 (100%)                              
      Centrilobular, Necrosis                                       2 (4%)       2 (4%)       2 (4%)                                
   Mesentery                                          (11)         (6)          (6)          (6)                                    
      Fat, Inflammation, Chronic, Multifocal           1 (9%)                                                                       
      Fat, Necrosis, Focal                             5 (45%)      4 (67%)      3 (50%)      1 (17%)                               
      Fat, Necrosis, Multifocal                        2 (18%)                                                                      
   Pancreas                                           (50)         (50)         (49)         (50)                                   
      Basophilic Focus                                 1 (2%)       2 (4%)       6 (12%)      1 (2%)                                
      Acinus, Atrophy, Focal                                                     2 (4%)                                             
      Acinus, Atrophy, Multifocal                     24 (48%)     32 (64%)     37 (76%)     41 (82%)                               
      Acinus, Hyperplasia, Focal                       1 (2%)       1 (2%)       3 (6%)       4 (8%)                                
      Acinus, Hyperplasia, Multifocal                  1 (2%)       1 (2%)                                                          
      Artery, Hypertrophy                                                                     1 (2%)                                
      Artery, Inflammation, Subacute                   1 (2%)       1 (2%)                    3 (6%)                                
      Duct, Cyst                                       1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
   Salivary Glands                                    (50)         (10)         (22)         (50)                                   
      Acinus, Atrophy, Multifocal                                                             1 (2%)                                
      Acinus, Hyperplasia, Multifocal                                            1 (5%)                                             
   Stomach, Forestomach                               (50)         (10)         (22)         (49)                                   
      Edema                                                                      3 (14%)      2 (4%)                                
      Erosion                                                                    1 (5%)                                             
      Hyperplasia                                                   1 (10%)      2 (9%)       1 (2%)                                
      Inflammation, Subacute                                        1 (10%)      5 (23%)      3 (6%)                                
      Mineralization                                                                          1 (2%)                                
      Perforation                                                                1 (5%)                                             
      Ulcer                                                         1 (10%)                   1 (2%)                                
      Ulcer, Multiple                                  1 (2%)                    2 (9%)                                             
   Stomach, Glandular                                 (50)         (10)         (22)         (49)                                   
      Edema                                                                      2 (9%)                                             
      Inflammation, Subacute                                                     2 (9%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05019-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 14:37:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     0.6%         1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Mineralization                                   1 (2%)                    5 (23%)     16 (33%)                               
   Tongue                                             (1)                                                                           
      Foreign Body, Multiple                           1 (100%)                                                                     
      Granuloma, Multiple                              1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                       (5)          (7)                                    
      Abdominal, Hypertrophy                                                     2 (40%)      4 (57%)                               
      Abdominal, Inflammation, Subacute                                          1 (20%)      1 (14%)                               
      Abdominal, Mineralization                                                  1 (20%)      4 (57%)                               
      Abdominal, Thrombosis                                                                   1 (14%)                               
      Aorta, Mineralization                            1 (100%)                  2 (40%)      4 (57%)                               
   Heart                                              (50)         (11)         (27)         (50)                                   
      Cardiomyopathy                                  40 (80%)      6 (55%)     22 (81%)     45 (90%)                               
      Fibrosis, Focal                                  1 (2%)                    1 (4%)       1 (2%)                                
      Inflammation, Multifocal, Subacute               1 (2%)                                                                       
      Mineralization, Multifocal                       1 (2%)                    2 (7%)       5 (10%)                               
      Atrium, Thrombosis                               1 (2%)       3 (27%)      5 (19%)      4 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)         (50)                                   
      Cyst                                                                                    1 (2%)                                
      Degeneration, Fatty, Focal                      11 (22%)     12 (24%)     11 (22%)     15 (30%)                               
      Degeneration, Fatty, Multifocal                  2 (4%)       1 (2%)       4 (8%)       1 (2%)                                
      Hyperplasia, Focal                               8 (16%)     10 (20%)     14 (28%)     16 (32%)                               
      Hyperplasia, Multifocal                          2 (4%)                    4 (8%)                                             
      Inflammation, Granulomatous, Multifocal                                    2 (4%)       1 (2%)                                
      Necrosis, Multifocal                             1 (2%)                                                                       
      Pigmentation, Multifocal, Cholesterol                                      2 (4%)       1 (2%)                                
      Capsule, Accessory Adrenal Cortical Nodule       2 (4%)       5 (10%)      5 (10%)                                            
      Capsule, Hemorrhage                              1 (2%)                                                                       
   Adrenal Gland, Medulla                             (50)         (50)         (50)         (50)                                   
      Hyperplasia, Focal                              22 (44%)      4 (8%)       9 (18%)     21 (42%)                               
      Hyperplasia, Multifocal                                       4 (8%)       3 (6%)       5 (10%)                               
      Thrombosis                                                                              1 (2%)                                
   Islets, Pancreatic                                 (50)         (50)         (49)         (50)                                   
      Hyperplasia                                      1 (2%)                                                                       
   Parathyroid Gland                                  (48)         (12)         (21)         (49)                                   
      Hyperplasia                                      2 (4%)       2 (17%)      9 (43%)     34 (69%)                               
   Pituitary Gland                                    (50)         (16)         (25)         (50)                                   
      Pars Distalis, Angiectasis                      18 (36%)      9 (56%)      6 (24%)      7 (14%)                               
      Pars Distalis, Cyst                              5 (10%)      3 (19%)      5 (20%)      8 (16%)                               
      Pars Distalis, Hemorrhage                        1 (2%)       1 (6%)       2 (8%)       1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05019-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 14:37:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     0.6%         1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Distalis, Hyperplasia, Focal                5 (10%)      3 (19%)      2 (8%)       8 (16%)                               
      Pars Distalis, Necrosis                                                    2 (8%)                                             
      Pars Distalis, Pigmentation, Hemosiderin         2 (4%)       1 (6%)       2 (8%)       1 (2%)                                
   Thyroid Gland                                      (50)         (11)         (23)         (50)                                   
      Inflammation, Acute, Suppurative                                                        1 (2%)                                
      Ultimobranchial Cyst                                                       1 (4%)       1 (2%)                                
      C-Cell, Hyperplasia, Focal                       4 (8%)       1 (9%)       1 (4%)       5 (10%)                               
      Follicle, Cyst                                   1 (2%)                    1 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (1)                                                                           
      Dilatation                                       1 (100%)                                                                     
      Inflammation                                     1 (100%)                                                                     
   Epididymis                                         (50)         (10)         (23)         (50)                                   
      Granuloma Sperm                                                                         1 (2%)                                
      Inflammation, Subacute                           1 (2%)                                                                       
   Preputial Gland                                    (49)         (13)         (25)         (50)                                   
      Foreign Body                                                                            1 (2%)                                
      Hyperplasia                                      4 (8%)       2 (15%)                   1 (2%)                                
      Inflammation, Subacute                           5 (10%)      3 (23%)      3 (12%)      4 (8%)                                
      Duct, Cyst                                       5 (10%)      2 (15%)      2 (8%)       1 (2%)                                
   Prostate                                           (50)         (10)         (22)         (50)                                   
      Inflammation, Subacute                          31 (62%)      7 (70%)     15 (68%)     22 (44%)                               
   Seminal Vesicle                                    (50)         (11)         (22)         (50)                                   
      Dilatation                                       2 (4%)       1 (9%)                                                          
      Hyperplasia, Focal                                                         1 (5%)                                             
      Inflammation, Subacute                           1 (2%)       1 (9%)       1 (5%)       1 (2%)                                
   Testes                                             (50)         (49)         (48)         (50)                                   
      Atrophy                                         10 (20%)     12 (24%)      8 (17%)      7 (14%)                               
      Hemorrhage                                                                 1 (2%)                                             
      Mineralization                                   1 (2%)                    1 (2%)                                             
      Interstitial Cell, Hyperplasia, Focal                         3 (6%)                                                          
      Interstitial Cell, Hyperplasia, Multifocal       5 (10%)      7 (14%)      4 (8%)      10 (20%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05019-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 14:37:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     0.6%         1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (1)                       (1)                                                 
      Leukocytosis                                                               1 (100%)                                           
   Bone Marrow                                        (50)         (10)         (22)         (49)                                   
      Hyperplasia                                     19 (38%)                   3 (14%)     19 (39%)                               
      Myelofibrosis                                    3 (6%)       1 (10%)                                                         
   Lymph Node                                         (50)         (50)         (50)         (50)                                   
      Axillary, Congestion                                                       1 (2%)                                             
      Axillary, Ectasia                                                          1 (2%)                                             
      Inguinal, Hyperplasia, Lymphoid                  1 (2%)                                                                       
      Mediastinal, Amyloid Deposition                                            1 (2%)                                             
      Mediastinal, Congestion                          2 (4%)       3 (6%)       6 (12%)      9 (18%)                               
      Mediastinal, Ectasia                             4 (8%)       1 (2%)       5 (10%)                                            
      Mediastinal, Hyperplasia, Macrophage,                                                                                         
          Multifocal                                                                          1 (2%)                                
      Mediastinal, Pigmentation, Hemosiderin           1 (2%)                    1 (2%)                                             
      Mesenteric, Congestion                           2 (4%)                                 2 (4%)                                
      Mesenteric, Ectasia                              1 (2%)       6 (12%)      5 (10%)      3 (6%)                                
      Mesenteric, Fibrosis, Focal                                                             2 (4%)                                
      Mesenteric, Giant Cell                                        1 (2%)                                                          
      Mesenteric, Hyperplasia, Macrophage,                                                                                          
          Multifocal                                  50 (100%)    47 (94%)     48 (96%)     49 (98%)                               
      Mesenteric, Necrosis, Focal                                                2 (4%)       2 (4%)                                
      Mesenteric, Necrosis, Multifocal                                           1 (2%)                                             
      Mesenteric, Pigmentation, Multifocal,                                                                                         
          Cholesterol                                 50 (100%)    47 (94%)     48 (96%)     49 (98%)                               
      Pancreatic, Amyloid Deposition                                1 (2%)                                                          
      Pancreatic, Ectasia                              1 (2%)                                 1 (2%)                                
      Pancreatic, Hyperplasia, Macrophage,                                                                                          
          Multifocal                                   1 (2%)       3 (6%)       3 (6%)       5 (10%)                               
      Pancreatic, Pigmentation, Multifocal,                                                                                         
          Cholesterol                                  1 (2%)       4 (8%)       3 (6%)       5 (10%)                               
      Renal, Congestion                                                          1 (2%)                                             
      Renal, Hyperplasia, Macrophage, Multifocal                                 1 (2%)       1 (2%)                                
      Renal, Pigmentation, Multifocal, Cholesterol                               1 (2%)       1 (2%)                                
   Lymph Node, Mandibular                             (48)         (50)         (50)         (50)                                   
      Congestion                                       1 (2%)                    1 (2%)       1 (2%)                                
      Ectasia                                         16 (33%)     17 (34%)     16 (32%)     20 (40%)                               
   Spleen                                             (50)         (50)         (50)         (49)                                   
      Fibrosis, Focal                                  6 (12%)      4 (8%)       8 (16%)      9 (18%)                               
      Fibrosis, Multifocal                             1 (2%)                    1 (2%)                                             
      Hematopoietic Cell Proliferation                 1 (2%)                    1 (2%)                                             
      Infiltration Cellular, Lipocyte                  1 (2%)                                 1 (2%)                                
      Necrosis, Focal                                  1 (2%)       1 (2%)                                                          
      Capsule, Cyst                                                 1 (2%)                                                          
   Thymus                                             (44)         (10)         (19)         (49)                                   
      Cyst                                             3 (7%)                                 2 (4%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05019-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 14:37:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     0.6%         1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (13)         (24)         (48)                                   
      Hyperplasia                                      5 (10%)      2 (15%)      2 (8%)       5 (10%)                               
      Inflammation, Chronic                                                                   1 (2%)                                
      Duct, Cyst                                      13 (26%)      5 (38%)      7 (29%)     11 (23%)                               
      Duct, Inflammation, Subacute                                                            1 (2%)                                
   Skin                                               (50)         (31)         (47)         (50)                                   
      Hyperkeratosis, Focal                                         2 (6%)                                                          
      Hyperkeratosis, Multifocal                                                 1 (2%)                                             
      Hyperplasia, Focal                               1 (2%)       2 (6%)       4 (9%)       2 (4%)                                
      Hyperplasia, Multifocal                                                    1 (2%)                                             
      Inflammation, Multifocal, Subacute                                         1 (2%)                                             
      Subcutaneous Tissue, Abscess, Focal              1 (2%)                                                                       
      Subcutaneous Tissue, Inflammation, Focal,                                                                                     
           Subacute                                                              1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (10)         (22)         (50)                                   
      Fibrous Osteodystrophy                           1 (2%)                    8 (36%)     36 (72%)                               
      Cranium, Hypertrophy, Focal                                                1 (5%)                                             
   Skeletal Muscle                                                 (1)                       (1)                                    
      Fibrosis, Focal                                               1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (11)         (22)         (50)                                   
      Compression                                      3 (6%)                    2 (9%)       2 (4%)                                
      Hemorrhage, Multifocal                           1 (2%)       3 (27%)      4 (18%)                                            
      Necrosis, Focal                                                            1 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                       1 (2%)                    1 (2%)                                             
      Inflammation, Acute, Suppurative                              1 (2%)                                                          
      Necrosis                                                      2 (4%)                                                          
      Pigmentation, Hemosiderin, Multifocal                         1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia, Focal          1 (2%)                    2 (4%)       2 (4%)                                
      Alveolar Epithelium, Hyperplasia, Multifocal     1 (2%)       1 (2%)                    1 (2%)                                
      Bronchus, Fungus                                              1 (2%)                                                          
      Bronchus, Inflammation, Acute, Suppurative                    1 (2%)                                                          
      Pleura, Congestion, Multifocal                                                          1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05019-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 14:37:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     0.6%         1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Pleura, Fibrosis, Focal                                       1 (2%)                    1 (2%)                                
   Nose                                               (50)         (10)         (22)         (50)                                   
      Foreign Body                                     9 (18%)      1 (10%)      7 (32%)      7 (14%)                               
      Fungus                                          12 (24%)                   9 (41%)     12 (24%)                               
      Hyperkeratosis                                                             1 (5%)                                             
      Inflammation, Acute, Suppurative                13 (26%)      1 (10%)     10 (45%)     13 (26%)                               
      Nasolacrimal Duct, Foreign Body                                            1 (5%)                                             
      Nasolacrimal Duct, Inflammation, Acute,                                                                                       
          Suppurative                                                            2 (9%)                                             
      Nasolacrimal Duct, Inflammation, Subacute       13 (26%)      1 (10%)                  22 (44%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (15)         (16)         (15)         (12)                                   
      Cataract                                        13 (87%)     16 (100%)    14 (93%)     10 (83%)                               
      Anterior Chamber, Hemorrhage                                  3 (19%)      2 (13%)                                            
      Anterior Chamber, Inflammation, Acute,                                                                                        
          Suppurative                                                            1 (7%)                                             
      Conjunctiva, Inflammation, Acute, Suppurative                              1 (7%)                                             
      Cornea, Fibrosis                                              2 (13%)                                                         
      Cornea, Inflammation, Acute, Suppurative                                   1 (7%)                                             
      Cornea, Inflammation, Subacute                                1 (6%)       1 (7%)                                             
      Lids, Fibrosis, Focal                            2 (13%)                                                                      
      Posterior Chamber, Hemorrhage                    1 (7%)       4 (25%)      1 (7%)                                             
      Retina, Degeneration                            13 (87%)     16 (100%)    14 (93%)     12 (100%)                              
   Zymbal's Gland                                                               (2)          (3)                                    
      Inflammation, Acute, Suppurative                                                        1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (49)                                   
      Hydronephrosis                                   1 (2%)                                 2 (4%)                                
      Metaplasia, Osseous                              1 (2%)                                                                       
      Nephropathy, Chronic                            50 (100%)    49 (98%)     50 (100%)    49 (100%)                              
      Cortex, Cyst                                     1 (2%)       2 (4%)       6 (12%)      2 (4%)                                
      Cortex, Cyst, Multiple                           2 (4%)       4 (8%)       7 (14%)     15 (31%)                               
      Papilla, Necrosis                                1 (2%)                                                                       
      Papilla, Transitional Epithelium, Hyperplasia    7 (14%)     40 (80%)     43 (86%)     43 (88%)                               
      Pelvis, Transitional Epithelium, Hyperplasia                               1 (2%)                                             
      Renal Tubule, Hyperplasia                        2 (4%)       3 (6%)       2 (4%)       7 (14%)                               
      Renal Tubule, Mineralization, Multifocal         1 (2%)                    2 (4%)       4 (8%)                                
   Urethra                                            (2)                                                                           
      Bulbourethral Gland, Congestion                  1 (50%)                                                                      
      Bulbourethral Gland, Dilatation                  2 (100%)                                                                     
      Bulbourethral Gland, Inflammation, Subacute      1 (50%)                                                                      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05019-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          CI PIGMENT RED 3                                     Date: 09/03/94  
Route: DOSED FEED                                                                                                 Time: 14:37:32  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     UNTREATD     0.6%         1.25%        2.5%                                      
                                                    CONTROL                                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
   Urinary Bladder                                    (50)         (11)         (22)         (50)                                   
      Inflammation, Subacute                           1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
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