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https://ntp.niehs.nih.gov/go/3775

TDMS Study 05028-01 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                          HEXACHLOROETHANE


NTP Experiment-Test: 05028-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/04/94
Route: GAVAGE                                                                                                     Time: 09:34:47




       Facility:  TSI Mason Research

       Chemical CAS #:  67-72-1

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05028-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 09:34:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      .08G/KG      .16G/KG                                                
                                                    FEMALE       LF           HF                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               4            2            3                                                  
    Moribund                                          14           20           15                                                  
    Accident                                                        1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           27           32                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (48)         (10)         (48)                                                
      Parasite Metazoan                                2 (4%)       1 (10%)      5 (10%)                                            
   Intestine Large, Colon                             (48)         (10)         (48)                                                
      Parasite Metazoan                                8 (17%)                   7 (15%)                                            
   Intestine Large, Rectum                            (50)         (10)         (47)                                                
      Parasite Metazoan                                4 (8%)       1 (10%)     12 (26%)                                            
   Liver                                              (50)         (32)         (50)                                                
      Angiectasis, Focal                               1 (2%)                                                                       
      Basophilic Focus                                26 (52%)     17 (53%)     28 (56%)                                            
      Basophilic Focus, Multiple                                    1 (3%)                                                          
      Cytoplasmic Alteration                                        1 (3%)                                                          
      Fatty Change                                    19 (38%)     11 (34%)     20 (40%)                                            
      Granuloma                                        2 (4%)       4 (13%)      5 (10%)                                            
      Hemorrhage, Focal                                             1 (3%)                                                          
      Hepatodiaphragmatic Nodule                       2 (4%)       7 (22%)      4 (8%)                                             
      Mixed Cell Focus                                 1 (2%)                                                                       
      Necrosis, Focal                                 16 (32%)      5 (16%)     14 (28%)                                            
      Bile Duct, Cyst                                               1 (3%)                                                          
      Bile Duct, Hyperplasia                          21 (42%)      5 (16%)     21 (42%)                                            
      Periductular, Inflammation, Chronic              1 (2%)                    1 (2%)                                             
      Perivascular, Inflammation, Chronic              3 (6%)                                                                       
   Mesentery                                          (7)          (5)          (5)                                                 
      Accessory Spleen                                              1 (20%)                                                         
      Granuloma                                                                  1 (20%)                                            
      Hemorrhage                                                    1 (20%)                                                         
      Fat, Inflammation                                             1 (20%)                                                         
      Fat, Necrosis                                    6 (86%)      3 (60%)      5 (100%)                                           
   Pancreas                                           (48)         (12)         (49)                                                
      Inflammation, Chronic, Focal                     1 (2%)       1 (8%)                                                          
      Acinus, Atrophy                                  9 (19%)      1 (8%)       5 (10%)                                            
      Acinus, Hyperplasia, Focal                       2 (4%)                    2 (4%)                                             
      Artery, Inflammation                                                       1 (2%)                                             
   Salivary Glands                                    (50)         (10)         (50)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05028-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 09:34:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      .08G/KG      .16G/KG                                                
                                                    FEMALE       LF           HF                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation, Chronic                                         1 (10%)      1 (2%)                                             
      Acinus, Atrophy, Focal                           1 (2%)                                                                       
   Stomach                                            (50)         (12)         (50)                                                
      Lumen, Thrombosis                                                          1 (2%)                                             
   Stomach, Forestomach                               (50)         (12)         (50)                                                
      Acanthosis                                                    1 (8%)       3 (6%)                                             
      Hyperkeratosis                                                             1 (2%)                                             
      Hyperplasia, Basal Cell, Focal                   1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)       1 (8%)                                                          
      Inflammation, Chronic Active                                               2 (4%)                                             
      Mineralization, Focal                                                      1 (2%)                                             
   Stomach, Glandular                                 (49)         (10)         (50)                                                
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      Mineralization, Focal                            2 (4%)                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (11)         (50)                                                
      Cardiomyopathy                                  28 (56%)      3 (27%)     27 (54%)                                            
      Artery, Inflammation, Chronic, Focal                                       1 (2%)                                             
      Atrium Right, Thrombosis                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (15)         (50)                                                
      Accessory Adrenal Cortical Nodule                                          1 (2%)                                             
      Atrophy                                                       1 (7%)                                                          
      Congestion                                       1 (2%)       1 (7%)                                                          
      Cytoplasmic Alteration, Focal                    7 (14%)      3 (20%)      5 (10%)                                            
      Hypertrophy                                      1 (2%)                                                                       
   Adrenal Gland, Medulla                             (50)         (15)         (46)                                                
      Hyperplasia, Focal                               5 (10%)                   7 (15%)                                            
      Inflammation, Focal                                           1 (7%)                                                          
   Islets, Pancreatic                                 (49)         (11)         (49)                                                
      Hyperplasia                                      1 (2%)                                                                       
   Pituitary Gland                                    (50)         (49)         (49)                                                
      Pars Distalis, Angiectasis                       4 (8%)       1 (2%)       7 (14%)                                            
      Pars Distalis, Cyst                             25 (50%)     21 (43%)     23 (47%)                                            
      Pars Distalis, Hyperplasia, Focal                5 (10%)     11 (22%)      8 (16%)                                            
      Pars Intermedia, Angiectasis                                               3 (6%)                                             
      Pars Intermedia, Cyst                            1 (2%)                                                                       
   Thyroid Gland                                      (50)         (50)         (50)                                                
      Fibrosis                                         1 (2%)                                                                       
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05028-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 09:34:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      .08G/KG      .16G/KG                                                
                                                    FEMALE       LF           HF                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pigmentation                                     1 (2%)                                                                       
      Ultimobranchial Cyst                                                       2 (4%)                                             
      C-Cell, Hyperplasia                             19 (38%)     11 (22%)     12 (24%)                                            
      Follicle, Cyst                                                1 (2%)       2 (4%)                                             
      Follicle, Hyperplasia, Focal                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (46)         (10)         (39)                                                
      Abscess                                          3 (7%)                    1 (3%)                                             
      Atrophy                                          1 (2%)                                                                       
      Cyst                                             1 (2%)                                                                       
      Dilatation                                                                 1 (3%)                                             
      Hemorrhage                                                                 1 (3%)                                             
      Hypertrophy                                                                1 (3%)                                             
      Inflammation, Acute                              1 (2%)                    3 (8%)                                             
      Inflammation, Chronic                           11 (24%)      1 (10%)      4 (10%)                                            
   Ovary                                              (50)         (14)         (50)                                                
      Congestion                                       1 (2%)       1 (7%)       2 (4%)                                             
      Cyst                                             7 (14%)      4 (29%)      4 (8%)                                             
   Uterus                                             (48)         (25)         (50)                                                
      Abscess                                                                    1 (2%)                                             
      Dilatation                                       5 (10%)      5 (20%)      4 (8%)                                             
      Exudate                                          2 (4%)                                                                       
      Inflammation, Acute, Focal                                    1 (4%)                                                          
      Inflammation, Chronic                                                      1 (2%)                                             
      Thrombosis                                       3 (6%)       2 (8%)       2 (4%)                                             
      Cervix, Hypertrophy                                           1 (4%)                                                          
      Endometrium, Cyst                                2 (4%)                    1 (2%)                                             
      Endometrium, Hyperplasia                         1 (2%)                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (11)         (49)                                                
      Hyperplasia                                     11 (22%)                   4 (8%)                                             
   Lymph Node                                         (49)         (17)         (50)                                                
      Inguinal, Infiltration Cellular, Plasma Cell                  1 (6%)                                                          
      Lumbar, Congestion                               1 (2%)                                                                       
      Lumbar, Infiltration Cellular, Plasma Cell       1 (2%)                                                                       
      Lumbar, Infiltration Cellular, Histiocyte        1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05028-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 09:34:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      .08G/KG      .16G/KG                                                
                                                    FEMALE       LF           HF                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Mediastinal, Congestion                          2 (4%)       1 (6%)       1 (2%)                                             
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
          Cell                                         1 (2%)                                                                       
      Mediastinal, Inflammation, Granulomatous         1 (2%)                                                                       
      Mediastinal, Pigmentation                                     1 (6%)                                                          
      Pancreatic, Angiectasis                                                    1 (2%)                                             
      Pancreatic, Congestion                                                     1 (2%)                                             
      Pancreatic, Hemorrhage                                        1 (6%)                                                          
      Renal, Congestion                                2 (4%)       1 (6%)       2 (4%)                                             
      Renal, Granuloma                                                           2 (4%)                                             
      Renal, Pigmentation                                           1 (6%)                                                          
   Lymph Node, Mandibular                             (46)         (10)         (43)                                                
      Angiectasis                                      1 (2%)                    2 (5%)                                             
      Congestion                                       4 (9%)       2 (20%)                                                         
      Infiltration Cellular, Plasma Cell              28 (61%)      3 (30%)     29 (67%)                                            
   Lymph Node, Mesenteric                             (48)         (12)         (49)                                                
      Angiectasis                                      1 (2%)                                                                       
      Congestion                                       2 (4%)                    2 (4%)                                             
      Granuloma                                                                  2 (4%)                                             
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Infiltration Cellular, Plasma Cell               1 (2%)                                                                       
      Pigmentation                                                               2 (4%)                                             
      Pigmentation, Hemosiderin                        3 (6%)       1 (8%)       1 (2%)                                             
   Spleen                                             (50)         (23)         (50)                                                
      Congestion                                                                 2 (4%)                                             
      Hematopoietic Cell Proliferation                17 (34%)      5 (22%)     18 (36%)                                            
      Necrosis, Focal                                  2 (4%)       1 (4%)                                                          
      Pigmentation, Hemosiderin                        5 (10%)      6 (26%)      3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (28)         (46)                                                
      Ectasia                                          3 (6%)                    7 (15%)                                            
      Galactocele                                     10 (21%)     16 (57%)     12 (26%)                                            
      Hypertrophy                                      3 (6%)                                                                       
      Inflammation, Focal, Subacute                                              1 (2%)                                             
   Skin                                               (49)         (12)         (48)                                                
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
      Subcutaneous Tissue, Abscess                                  1 (8%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05028-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 09:34:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      .08G/KG      .16G/KG                                                
                                                    FEMALE       LF           HF                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (10)         (50)                                                
      Cranium, Hyperostosis                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (10)         (50)                                                
      Congestion                                                                 1 (2%)                                             
      Hemorrhage                                       1 (2%)       1 (10%)      1 (2%)                                             
      Hydrocephalus                                    2 (4%)       1 (10%)      1 (2%)                                             
      Infarct                                                                    1 (2%)                                             
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
   Spinal Cord                                        (38)                      (38)                                                
      Degeneration                                                               1 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (29)         (50)                                                
      Congestion                                       2 (4%)      14 (48%)      4 (8%)                                             
      Granuloma                                        2 (4%)       1 (3%)       3 (6%)                                             
      Hemorrhage, Focal                                1 (2%)       3 (10%)      3 (6%)                                             
      Infiltration Cellular, Histiocyte                             1 (3%)                                                          
      Pigmentation, Focal, Hemosiderin                 1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia, Adenomatous    1 (2%)                                                                       
      Alveolar Epithelium, Metaplasia                  2 (4%)       1 (3%)       4 (8%)                                             
      Alveolus, Atypia Cellular                                     1 (3%)                                                          
      Artery, Thrombosis                                                         1 (2%)                                             
      Peribronchial, Inflammation, Chronic            29 (58%)     10 (34%)     32 (64%)                                            
   Nose                                               (49)         (9)          (50)                                                
      Inflammation, Chronic                           16 (33%)      3 (33%)     20 (40%)                                            
      Metaplasia, Squamous                            39 (80%)      1 (11%)     41 (82%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (6)          (6)          (6)                                                 
      Cataract                                         2 (33%)                   1 (17%)                                            
      Retinal Detachment                                                         1 (17%)                                            
      Cornea, Inflammation, Acute                                                1 (17%)                                            
      Lens, Mineralization, Focal                                   2 (33%)                                                         
      Posterior Chamber, Hemorrhage                                 1 (17%)                                                         
      Retina, Degeneration                             2 (33%)      1 (17%)                                                         
      Vitreous, Degeneration                                                     1 (17%)                                            
   Harderian Gland                                                 (3)          (1)                                                 
      Inflammation, Chronic, Focal                                  2 (67%)                                                         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05028-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 09:34:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      .08G/KG      .16G/KG                                                
                                                    FEMALE       LF           HF                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Casts                                            1 (2%)                    2 (4%)                                             
      Inflammation, Chronic                                         1 (2%)       1 (2%)                                             
      Mineralization                                  14 (28%)     22 (44%)     13 (26%)                                            
      Nephropathy                                     22 (44%)     42 (84%)     45 (90%)                                            
      Renal Tubule, Cyst                                                         2 (4%)                                             
      Renal Tubule, Hyperplasia                                     1 (2%)                                                          
      Renal Tubule, Pigmentation                       2 (4%)       2 (4%)       3 (6%)                                             
      Renal Tubule, Regeneration                                    2 (4%)       1 (2%)                                             
   Urinary Bladder                                    (46)         (11)         (47)                                                
      Hyperplasia                                                   1 (9%)                                                          
      Inflammation, Chronic                                         2 (18%)                                                         
      Transitional Epithelium, Hyperplasia                                       1 (2%)                                             
      Transitional Epithelium, Hyperplasia,                                                                                         
          Squamous                                                  1 (9%)                                                          
      Wall, Inflammation, Chronic Active                                         1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05028-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 09:34:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      .01G/KG      .02G/KG                                                
                                                   MALE          LM           HM                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          16           14           19                                                  
    Accident                                           1            1                                                               
    Dead                                               2            6            4                                                  
    Gavage Death                                                                 1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                31           29           26                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (13)         (49)                                                
      Foreign Body                                                  1 (8%)                                                          
      Perforation                                                   1 (8%)                                                          
      Periesophageal Tissue, Inflammation, Acute                    1 (8%)                                                          
      Periesophageal Tissue, Inflammation, Chronic                                                                                  
          Active                                       1 (2%)                                                                       
   Intestine Large, Cecum                             (49)         (12)         (45)                                                
      Parasite Metazoan                                4 (8%)       1 (8%)       2 (4%)                                             
   Intestine Large, Colon                             (50)         (13)         (46)                                                
      Parasite Metazoan                               10 (20%)      1 (8%)       4 (9%)                                             
   Intestine Large, Rectum                            (50)         (12)         (47)                                                
      Parasite Metazoan                               10 (20%)      1 (8%)       8 (17%)                                            
   Intestine Small, Ileum                             (49)         (14)         (47)                                                
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Parasite Metazoan                                1 (2%)                    1 (2%)                                             
   Liver                                              (50)         (31)         (50)                                                
      Angiectasis                                      1 (2%)                                                                       
      Basophilic Focus                                11 (22%)     10 (32%)     26 (52%)                                            
      Congestion                                       1 (2%)       2 (6%)                                                          
      Cytoplasmic Alteration, Focal                    2 (4%)       2 (6%)       2 (4%)                                             
      Fatty Change                                    27 (54%)     14 (45%)     22 (44%)                                            
      Fibrosis, Focal                                                            1 (2%)                                             
      Hepatodiaphragmatic Nodule                       1 (2%)       3 (10%)      2 (4%)                                             
      Hyperplasia                                      1 (2%)                                                                       
      Hyperplasia, Focal                                            1 (3%)                                                          
      Mineralization, Focal                                                      1 (2%)                                             
      Necrosis, Focal                                 20 (40%)      3 (10%)     23 (46%)                                            
      Bile Duct, Hyperplasia                          40 (80%)     24 (77%)     42 (84%)                                            
      Centrilobular, Necrosis, Focal                                1 (3%)                                                          
      Serosa, Proliferation                                         1 (3%)                                                          
   Mesentery                                          (1)          (5)          (5)                                                 
      Fat, Necrosis                                                 2 (40%)      2 (40%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05028-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 09:34:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      .01G/KG      .02G/KG                                                
                                                   MALE          LM           HM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Pancreas                                           (50)         (18)         (50)                                                
      Inflammation, Chronic                            1 (2%)                                                                       
      Acinus, Atrophy                                 23 (46%)      3 (17%)     11 (22%)                                            
      Acinus, Hyperplasia                              5 (10%)                   5 (10%)                                            
      Artery, Inflammation                                                       1 (2%)                                             
      Duct, Hyperplasia, Focal                                      1 (6%)                                                          
   Salivary Glands                                    (50)         (13)         (50)                                                
      Inflammation, Chronic                            1 (2%)                                                                       
      Karyomegaly, Focal                                                         2 (4%)                                             
   Stomach                                            (50)         (19)         (49)                                                
      Serosa, Fibrosis                                                           1 (2%)                                             
      Serosa, Inflammation, Chronic Active                                       1 (2%)                                             
   Stomach, Forestomach                               (48)         (18)         (49)                                                
      Acanthosis                                       1 (2%)       3 (17%)      3 (6%)                                             
      Cyst Epithelial Inclusion                                                  1 (2%)                                             
      Hyperkeratosis                                   4 (8%)       3 (17%)      2 (4%)                                             
      Hyperplasia, Basal Cell                          1 (2%)       1 (6%)       1 (2%)                                             
      Inflammation, Focal                              2 (4%)                                                                       
      Ulcer                                            2 (4%)       3 (17%)      3 (6%)                                             
      Epithelium, Hyperplasia                                                    1 (2%)                                             
   Stomach, Glandular                                 (50)         (19)         (49)                                                
      Erosion                                                                    1 (2%)                                             
      Infiltration Cellular, Lymphocyte                             2 (11%)      1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (15)         (50)                                                
      Cardiomyopathy                                  37 (74%)     14 (93%)     43 (86%)                                            
      Hemorrhage, Focal                                             1 (7%)                                                          
      Inflammation, Chronic                            1 (2%)       1 (7%)       1 (2%)                                             
      Mineralization                                   1 (2%)                                                                       
      Pigmentation, Hemosiderin                        1 (2%)       1 (7%)                                                          
      Atrium, Dilatation                                            2 (13%)      3 (6%)                                             
      Atrium, Thrombosis                               1 (2%)                    5 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
      Accessory Adrenal Cortical Nodule                1 (2%)                                                                       
      Cytoplasmic Alteration, Focal                    6 (12%)      1 (2%)       2 (4%)                                             
      Hyperplasia, Focal                               3 (6%)       5 (10%)      2 (4%)                                             
      Hypertrophy                                                                1 (2%)                                             
      Vacuolization Cytoplasmic                        2 (4%)       8 (16%)      2 (4%)                                             
   Adrenal Gland, Medulla                             (50)         (45)         (49)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05028-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 09:34:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      .01G/KG      .02G/KG                                                
                                                   MALE          LM           HM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hyperplasia, Focal                               6 (12%)      4 (9%)      10 (20%)                                            
      Thrombosis                                                    1 (2%)                                                          
   Islets, Pancreatic                                 (50)         (17)         (50)                                                
      Hyperplasia                                      4 (8%)                                                                       
   Parathyroid Gland                                  (41)         (40)         (43)                                                
      Cyst                                             1 (2%)                                                                       
      Hyperplasia                                                                1 (2%)                                             
   Pituitary Gland                                    (49)         (50)         (48)                                                
      Pars Distalis, Angiectasis                       2 (4%)                                                                       
      Pars Distalis, Cyst                              1 (2%)       1 (2%)       2 (4%)                                             
      Pars Distalis, Hemorrhage                        1 (2%)       1 (2%)                                                          
      Pars Distalis, Hyperplasia, Focal               11 (22%)     13 (26%)     13 (27%)                                            
      Pars Distalis, Pigmentation, Hemosiderin                      1 (2%)       1 (2%)                                             
      Pars Distalis, Vacuolization Cytoplasmic                                   1 (2%)                                             
      Pars Intermedia, Cyst                                         1 (2%)       1 (2%)                                             
      Pars Nervosa, Cyst                                                         1 (2%)                                             
   Thyroid Gland                                      (49)         (50)         (50)                                                
      C-Cell, Hyperplasia                             10 (20%)     10 (20%)     11 (22%)                                            
      Follicle, Cyst                                   2 (4%)       3 (6%)       4 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (14)         (50)                                                
      Atrophy                                          1 (2%)                    2 (4%)                                             
      Dilatation, Focal                                                          1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
   Preputial Gland                                    (46)         (17)         (49)                                                
      Abscess                                                       1 (6%)       3 (6%)                                             
      Atrophy                                          1 (2%)                                                                       
      Ectasia                                          2 (4%)                    2 (4%)                                             
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Acute                              1 (2%)                    4 (8%)                                             
      Inflammation, Chronic                           29 (63%)      6 (35%)     18 (37%)                                            
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)                                             
      Inflammation, Granulomatous                                                1 (2%)                                             
   Prostate                                           (50)         (13)         (48)                                                
      Abscess                                                       1 (8%)                                                          
      Atrophy                                                                    2 (4%)                                             
      Hyperplasia, Focal                               2 (4%)                    6 (13%)                                            
      Inflammation, Acute                              3 (6%)       2 (15%)      1 (2%)                                             
      Inflammation, Chronic                            8 (16%)      5 (38%)      5 (10%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05028-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 09:34:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      .01G/KG      .02G/KG                                                
                                                   MALE          LM           HM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Inflammation, Chronic Active                                               1 (2%)                                             
      Metaplasia, Squamous                                                       1 (2%)                                             
   Seminal Vesicle                                    (50)         (23)         (48)                                                
      Atrophy                                         27 (54%)     12 (52%)     29 (60%)                                            
      Dilatation                                                    2 (9%)                                                          
   Testes                                             (49)         (46)         (50)                                                
      Edema                                                         1 (2%)                                                          
      Necrosis                                                      1 (2%)                                                          
      Interstitial Cell, Hyperplasia                                2 (4%)                                                          
      Seminiferous Tubule, Atrophy                     8 (16%)      4 (9%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (13)         (49)                                                
      Hyperplasia                                      2 (4%)       2 (15%)      7 (14%)                                            
   Lymph Node                                         (50)         (31)         (50)                                                
      Axillary, Congestion                                          1 (3%)                                                          
      Inguinal, Angiectasis                            1 (2%)                                                                       
      Lumbar, Congestion                                            1 (3%)                                                          
      Lumbar, Hyperplasia                                                        1 (2%)                                             
      Lumbar, Infiltration Cellular, Plasma Cell       1 (2%)                                                                       
      Lumbar, Infiltration Cellular, Histiocyte        1 (2%)                                                                       
      Mediastinal, Congestion                          3 (6%)       4 (13%)      3 (6%)                                             
      Mediastinal, Infiltration Cellular, Plasma                                                                                    
          Cell                                                      2 (6%)                                                          
      Mediastinal, Pigmentation, Hemosiderin                                     1 (2%)                                             
      Pancreatic, Congestion                           1 (2%)       1 (3%)                                                          
      Pancreatic, Pigmentation, Hemosiderin                                      1 (2%)                                             
      Renal, Congestion                                1 (2%)       2 (6%)                                                          
      Renal, Hyperplasia, Lymphoid                                  1 (3%)                                                          
      Renal, Infiltration Cellular, Histiocyte         2 (4%)                                                                       
      Renal, Pigmentation, Hemosiderin                                           1 (2%)                                             
   Lymph Node, Mandibular                             (45)         (23)         (44)                                                
      Angiectasis                                      3 (7%)                    2 (5%)                                             
      Congestion                                       2 (4%)       5 (22%)      1 (2%)                                             
      Infiltration Cellular, Plasma Cell              26 (58%)     16 (70%)     29 (66%)                                            
      Lymphatic, Angiectasis                                        4 (17%)                                                         
   Lymph Node, Mesenteric                             (50)         (15)         (48)                                                
      Congestion                                       2 (4%)       2 (13%)      2 (4%)                                             
      Cyst                                                                       1 (2%)                                             
      Hyperplasia, Lymphoid                                                      2 (4%)                                             
      Infiltration Cellular, Plasma Cell                            1 (7%)                                                          
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
      Necrosis                                                      1 (7%)                                                          
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
   Spleen                                             (49)         (28)         (50)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05028-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 09:34:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      .01G/KG      .02G/KG                                                
                                                   MALE          LM           HM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Congestion                                       1 (2%)       1 (4%)       1 (2%)                                             
      Depletion Lymphoid                                                         1 (2%)                                             
      Fibrosis                                                      3 (11%)                                                         
      Fibrosis, Focal                                  3 (6%)       1 (4%)       1 (2%)                                             
      Hematopoietic Cell Proliferation                 6 (12%)      4 (14%)      8 (16%)                                            
      Necrosis                                         1 (2%)                                                                       
      Pigmentation, Hemosiderin                        4 (8%)       5 (18%)     11 (22%)                                            
   Thymus                                             (47)         (11)         (43)                                                
      Congestion                                                    2 (18%)                                                         
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (33)         (16)         (23)                                                
      Ectasia                                          1 (3%)                                                                       
      Galactocele                                      1 (3%)       4 (25%)                                                         
      Hemorrhage                                                                 1 (4%)                                             
      Hyperplasia, Glandular                           1 (3%)                                                                       
   Skin                                               (48)         (21)         (50)                                                
      Cyst Epithelial Inclusion                        1 (2%)                    3 (6%)                                             
      Hyperkeratosis                                                             1 (2%)                                             
      Subcutaneous Tissue, Fibrosis                                              1 (2%)                                             
      Subcutaneous Tissue, Necrosis                                 1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (13)         (50)                                                
      Tarsal, Hyperostosis                             1 (2%)                                                                       
   Skeletal Muscle                                    (4)          (2)          (2)                                                 
      Back, Hemorrhage, Focal                          1 (25%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (13)         (50)                                                
      Hemorrhage, Focal                                4 (8%)       4 (31%)      3 (6%)                                             
      Hydrocephalus                                    5 (10%)                   5 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (24)         (50)                                                
      Congestion                                       2 (4%)       7 (29%)      2 (4%)                                             
      Edema                                                         1 (4%)                                                          
      Embolus                                          1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05028-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 09:34:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      .01G/KG      .02G/KG                                                
                                                   MALE          LM           HM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Foreign Body                                                  1 (4%)       1 (2%)                                             
      Fungus                                           1 (2%)                                                                       
      Granuloma                                        1 (2%)       1 (4%)       4 (8%)                                             
      Hemorrhage, Focal                                             4 (17%)                                                         
      Infiltration Cellular, Histiocyte                             1 (4%)                                                          
      Alveolar Epithelium, Hyperplasia, Adenomatous    1 (2%)                    2 (4%)                                             
      Alveolar Epithelium, Metaplasia, Focal                        1 (4%)       2 (4%)                                             
      Artery, Ectasia                                                            1 (2%)                                             
      Peribronchial, Inflammation, Chronic            34 (68%)      5 (21%)     32 (64%)                                            
      Pleura, Inflammation, Acute                                   1 (4%)                                                          
   Nose                                               (50)         (13)         (50)                                                
      Foreign Body                                     1 (2%)                                                                       
      Fungus                                           3 (6%)       1 (8%)       2 (4%)                                             
      Hemorrhage, Focal                                             1 (8%)                                                          
      Inflammation, Acute                                           1 (8%)       1 (2%)                                             
      Inflammation, Chronic                           36 (72%)      7 (54%)     30 (60%)                                            
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Metaplasia, Squamous                            34 (68%)      1 (8%)      33 (66%)                                            
      Lymphatic, Angiectasis                                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)                       (2)                                                 
      Inflammation, Chronic, Focal                     1 (100%)                                                                     
   Eye                                                (5)          (3)          (2)                                                 
      Cataract                                         3 (60%)      1 (33%)                                                         
      Retina, Degeneration                             1 (20%)      1 (33%)      1 (50%)                                            
      Sclera, Mineralization, Focal                    1 (20%)                                                                      
      Vitreous, Hemorrhage                                                       1 (50%)                                            
   Harderian Gland                                                 (2)                                                              
      Inflammation, Chronic                                         1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Casts                                                                      2 (4%)                                             
      Congestion                                       2 (4%)                                                                       
      Cytomegaly                                                                 2 (4%)                                             
      Hemorrhage, Focal                                             1 (2%)                                                          
      Hyperplasia                                                   1 (2%)       1 (2%)                                             
      Inflammation, Chronic                                                      2 (4%)                                             
      Mineralization                                   2 (4%)      15 (30%)     32 (64%)                                            
      Nephropathy                                     48 (96%)     48 (96%)     47 (94%)                                            
      Artery, Inflammation, Chronic                                 1 (2%)                                                          
      Pelvis, Inflammation, Acute                                   2 (4%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05028-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 09:34:47  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      .01G/KG      .02G/KG                                                
                                                   MALE          LM           HM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Pelvis, Transitional Epithelium, Hyperplasia                  7 (14%)      7 (14%)                                            
      Renal Tubule, Cyst                               2 (4%)       3 (6%)       1 (2%)                                             
      Renal Tubule, Hyperplasia                        2 (4%)       4 (8%)      11 (22%)                                            
      Renal Tubule, Necrosis, Focal                                              1 (2%)                                             
      Renal Tubule, Pigmentation                       1 (2%)       4 (8%)       5 (10%)                                            
      Renal Tubule, Regeneration                       1 (2%)                    3 (6%)                                             
   Urinary Bladder                                    (47)         (10)         (46)                                                
      Concretion                                       4 (9%)       1 (10%)      2 (4%)                                             
      Lumen, Thrombosis                                             1 (10%)                                                         
      Transitional Epithelium, Hyperplasia                          1 (10%)      1 (2%)                                             
      Wall, Inflammation, Acute                                     1 (10%)                                                         
      Wall, Inflammation, Chronic Active                                         1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
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                             ----------              END OF REPORT             ----------                                           
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