National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3611

TDMS Study 05028-01 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                          HEXACHLOROETHANE


NTP Experiment-Test: 05028-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/04/94
Route: GAVAGE                                                                                                     Time: 09:34:50




       Facility:  TSI Mason Research

       Chemical CAS #:  67-72-1

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05028-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 09:34:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      .08G/KG      .16G/KG                                                
                                                    FEMALE       LF           HF                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               4            2            3                                                  
    Moribund                                          14           20           15                                                  
    Accident                                                        1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           27           32                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Ileum                             (48)         (10)         (47)                                                
   Intestine Small, Jejunum                           (50)         (10)         (48)                                                
   Liver                                              (50)         (32)         (50)                                                
      Carcinoma, Metastatic, Adrenal Gland                          1 (3%)                                                          
      Hepatocellular Carcinoma                                      1 (3%)                                                          
      Neoplastic Nodule                                1 (2%)       2 (6%)       1 (2%)                                             
   Mesentery                                          (7)          (5)          (5)                                                 
   Pancreas                                           (48)         (12)         (49)                                                
   Pharynx                                                                      (1)                                                 
      Palate, Squamous Cell Papilloma                                            1 (100%)                                           
   Stomach, Forestomach                               (50)         (12)         (50)                                                
   Stomach, Glandular                                 (49)         (10)         (50)                                                
      Sarcoma                                                                    1 (2%)                                             
   Tongue                                                          (1)                                                              
      Squamous Cell Papilloma                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (11)         (50)                                                
      Schwannoma Malignant                             1 (2%)                                                                       
      Ventricle Left, Schwannoma Malignant             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (15)         (50)                                                
      Adenoma                                          1 (2%)                    1 (2%)                                             
      Carcinoma                                                     1 (7%)                                                          
   Adrenal Gland, Medulla                             (50)         (15)         (46)                                                
      Pheochromocytoma Malignant                                    1 (7%)                                                          
      Pheochromocytoma Benign                          1 (2%)                    1 (2%)                                             
                                                             Page   2                                                               
NTP Experiment-Test: 05028-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 09:34:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      .08G/KG      .16G/KG                                                
                                                    FEMALE       LF           HF                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Bilateral, Pheochromocytoma Benign                            1 (7%)       1 (2%)                                             
   Islets, Pancreatic                                 (49)         (11)         (49)                                                
      Carcinoma                                                     1 (9%)                                                          
   Parathyroid Gland                                  (38)         (40)         (38)                                                
      Adenoma                                          1 (3%)                                                                       
   Pituitary Gland                                    (50)         (49)         (49)                                                
      Pars Distalis, Adenoma                          26 (52%)     20 (41%)     16 (33%)                                            
      Pars Distalis, Carcinoma                                                   1 (2%)                                             
   Thyroid Gland                                      (50)         (50)         (50)                                                
      C-Cell, Adenoma                                  9 (18%)      7 (14%)      6 (12%)                                            
      C-Cell, Carcinoma                                1 (2%)                                                                       
      Follicular Cell, Adenoma                                      1 (2%)                                                          
      Follicular Cell, Carcinoma                                                 2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (46)         (10)         (39)                                                
      Adenoma                                          3 (7%)                    2 (5%)                                             
      Carcinoma                                        1 (2%)       1 (10%)                                                         
   Ovary                                              (50)         (14)         (50)                                                
      Cystadenoma                                      1 (2%)                                                                       
   Uterus                                             (48)         (25)         (50)                                                
      Leiomyoma                                                                  1 (2%)                                             
      Polyp Stromal                                   10 (21%)      7 (28%)      5 (10%)                                            
      Cervix, Endometrium, Sarcoma Stromal             1 (2%)                                                                       
      Endometrium, Adenocarcinoma                      1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (11)         (49)                                                
   Lymph Node                                         (49)         (17)         (50)                                                
      Carcinosarcoma, Metastatic, Zymbal's Gland       1 (2%)                                                                       
   Lymph Node, Mandibular                             (46)         (10)         (43)                                                
   Lymph Node, Mesenteric                             (48)         (12)         (49)                                                
   Spleen                                             (50)         (23)         (50)                                                
   Thymus                                             (41)         (11)         (45)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05028-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 09:34:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      .08G/KG      .16G/KG                                                
                                                    FEMALE       LF           HF                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (28)         (46)                                                
      Adenocarcinoma                                                1 (4%)                                                          
      Fibroadenoma                                    17 (35%)     17 (61%)     20 (43%)                                            
      Fibroadenoma, Multiple                          11 (23%)      4 (14%)      4 (9%)                                             
   Skin                                               (49)         (12)         (48)                                                
      Keratoacanthoma                                               1 (8%)                                                          
      Squamous Cell Papilloma                          1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     1 (2%)       2 (17%)      1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (10)         (50)                                                
      Astrocytoma Malignant                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (29)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     2 (4%)                    1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                                             1 (2%)                                             
      Carcinoma, Metastatic, Adrenal Gland                          1 (3%)                                                          
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
   Nose                                               (49)         (9)          (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (6)          (6)          (6)                                                 
      Conjunctiva, Squamous Cell Carcinoma             1 (17%)                                                                      
   Harderian Gland                                                 (3)          (1)                                                 
      Adenocarcinoma                                                             1 (100%)                                           
   Zymbal's Gland                                     (2)                                                                           
      Carcinoma                                        2 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05028-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 09:34:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      .08G/KG      .16G/KG                                                
                                                    FEMALE       LF           HF                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
   Urinary Bladder                                    (46)         (11)         (47)                                                
      Transitional Epithelium, Papilloma               1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Monocytic                                            1 (2%)                                                          
      Leukemia Mononuclear                            19 (38%)     12 (24%)     15 (30%)                                            
      Lymphoma Malignant Lymphocytic                                             2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05028-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 09:34:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      .08G/KG      .16G/KG                                                
                                                    FEMALE       LF           HF                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          44          43                                                   
     Total Primary Neoplasms                          114          82          87                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 44          36          40                                                   
     Total Benign Neoplasms                            86          63          61                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              22          16          20                                                   
     Total Malignant Neoplasms                         28          19          26                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           1           1                                                   
     Total Metastatic Neoplasm                          1           2           1                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05028-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 09:34:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      .01G/KG      .02G/KG                                                
                                                   MALE          LM           HM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          16           14           19                                                  
    Accident                                           1            1                                                               
    Dead                                               2            6            4                                                  
    Gavage Death                                                                 1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                31           29           26                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (13)         (46)                                                
   Intestine Small, Duodenum                          (50)         (15)         (50)                                                
      Adenocarcinoma                                                             1 (2%)                                             
      Leiomyosarcoma                                   1 (2%)                                                                       
   Intestine Small, Ileum                             (49)         (14)         (47)                                                
      Leiomyosarcoma                                                1 (7%)                                                          
   Liver                                              (50)         (31)         (50)                                                
      Fibrosarcoma, Metastatic, Skin                                1 (3%)                                                          
      Hepatocellular Carcinoma                         1 (2%)                    1 (2%)                                             
      Neoplastic Nodule                                1 (2%)       1 (3%)       1 (2%)                                             
   Mesentery                                          (1)          (5)          (5)                                                 
      Sarcoma                                                                    1 (20%)                                            
   Pancreas                                           (50)         (18)         (50)                                                
      Adenoma                                                       1 (6%)                                                          
      Acinus, Adenoma                                               3 (17%)                                                         
   Pharynx                                                         (1)          (1)                                                 
      Palate, Squamous Cell Papilloma                               1 (100%)     1 (100%)                                           
   Stomach, Forestomach                               (48)         (18)         (49)                                                
      Squamous Cell Papilloma                                       1 (6%)                                                          
   Stomach, Glandular                                 (50)         (19)         (49)                                                
   Tongue                                                          (2)          (1)                                                 
      Squamous Cell Papilloma                                       1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (15)         (50)                                                
      Schwannoma Malignant                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05028-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 09:34:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      .01G/KG      .02G/KG                                                
                                                   MALE          LM           HM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)                                                
   Adrenal Gland, Medulla                             (50)         (45)         (49)                                                
      Pheochromocytoma Malignant                       1 (2%)       2 (4%)       1 (2%)                                             
      Pheochromocytoma Complex                                                   2 (4%)                                             
      Pheochromocytoma Benign                         11 (22%)     19 (42%)     15 (31%)                                            
      Bilateral, Pheochromocytoma Benign               3 (6%)       7 (16%)      4 (8%)                                             
   Islets, Pancreatic                                 (50)         (17)         (50)                                                
      Adenoma                                          2 (4%)       2 (12%)                                                         
      Carcinoma                                                                  2 (4%)                                             
   Parathyroid Gland                                  (41)         (40)         (43)                                                
      Adenoma                                                       1 (3%)       1 (2%)                                             
   Pituitary Gland                                    (49)         (50)         (48)                                                
      Pars Distalis, Adenoma                          24 (49%)     22 (44%)     16 (33%)                                            
   Thyroid Gland                                      (49)         (50)         (50)                                                
      C-Cell, Adenoma                                  6 (12%)      9 (18%)      5 (10%)                                            
      C-Cell, Carcinoma                                3 (6%)       2 (4%)                                                          
      Follicular Cell, Adenoma                                      1 (2%)                                                          
      Follicular Cell, Carcinoma                       1 (2%)                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (14)         (50)                                                
   Preputial Gland                                    (46)         (17)         (49)                                                
      Adenoma                                          1 (2%)       2 (12%)      2 (4%)                                             
      Carcinoma                                                     1 (6%)       1 (2%)                                             
      Bilateral, Adenoma                                                         1 (2%)                                             
   Prostate                                           (50)         (13)         (48)                                                
   Testes                                             (49)         (46)         (50)                                                
      Bilateral, Interstitial Cell, Adenoma           32 (65%)     36 (78%)     42 (84%)                                            
      Interstitial Cell, Adenoma                      11 (22%)      5 (11%)      3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (13)         (49)                                                
   Lymph Node                                         (50)         (31)         (50)                                                
   Lymph Node, Mandibular                             (45)         (23)         (44)                                                
   Lymph Node, Mesenteric                             (50)         (15)         (48)                                                
   Spleen                                             (49)         (28)         (50)                                                
   Thymus                                             (47)         (11)         (43)                                                
                                                             Page   8                                                               
NTP Experiment-Test: 05028-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 09:34:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      .01G/KG      .02G/KG                                                
                                                   MALE          LM           HM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Thymoma Benign                                                             2 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (33)         (16)         (23)                                                
      Adenocarcinoma                                   1 (3%)                    1 (4%)                                             
      Fibroadenoma                                     6 (18%)      6 (38%)      1 (4%)                                             
      Fibroadenoma, Multiple                           1 (3%)                                                                       
      Lipoma                                                        1 (6%)                                                          
   Skin                                               (48)         (21)         (50)                                                
      Basal Cell Adenoma                                            1 (5%)                                                          
      Basal Cell Carcinoma                             1 (2%)                                                                       
      Keratoacanthoma                                  6 (13%)      5 (24%)      5 (10%)                                            
      Squamous Cell Carcinoma                          1 (2%)                    1 (2%)                                             
      Squamous Cell Papilloma                          1 (2%)       1 (5%)                                                          
      Trichoepithelioma                                             1 (5%)                                                          
      Subcutaneous Tissue, Fibroma                     6 (13%)      3 (14%)      2 (4%)                                             
      Subcutaneous Tissue, Fibrosarcoma                2 (4%)       3 (14%)      2 (4%)                                             
      Subcutaneous Tissue, Lipoma                      1 (2%)       1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (13)         (50)                                                
      Osteosarcoma                                     1 (2%)                                                                       
   Skeletal Muscle                                    (4)          (2)          (2)                                                 
      Lipoma                                           1 (25%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (13)         (50)                                                
      Astrocytoma Malignant                            1 (2%)                                                                       
      Cranial Nerve, Schwannoma Malignant              1 (2%)                                                                       
   Spinal Cord                                                     (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (24)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     4 (8%)                    2 (4%)                                             
      Carcinoma, Metastatic, Kidney                                              1 (2%)                                             
   Nose                                               (50)         (13)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05028-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 09:34:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      .01G/KG      .02G/KG                                                
                                                   MALE          LM           HM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                 (2)                                                              
      Adenoma                                                       1 (50%)                                                         
   Zymbal's Gland                                     (2)                                                                           
      Carcinoma                                        1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Adenoma                                                                    1 (2%)                                             
      Renal Tubule, Adenoma                            1 (2%)       2 (4%)       3 (6%)                                             
      Renal Tubule, Carcinoma                                                    3 (6%)                                             
   Urinary Bladder                                    (47)         (10)         (46)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            13 (26%)     15 (30%)     11 (22%)                                            
      Mesothelioma Malignant                                        2 (4%)                                                          
      Mesothelioma NOS                                 1 (2%)       1 (2%)       5 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05028-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          HEXACHLOROETHANE                                     Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 09:34:50  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      .01G/KG      .02G/KG                                                
                                                   MALE          LM           HM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            48          49          48                                                   
     Total Primary Neoplasms                          149         161         141                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 48          49          48                                                   
     Total Benign Neoplasms                           118         134         107                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              24          22          22                                                   
     Total Malignant Neoplasms                         30          26          29                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          1           1                                                   
     Total Metastatic Neoplasm                                      1           1                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1           1           5                                                   
     Total Uncertain Neoplasms                          6           6          20                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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