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TDMS Study 05028-01 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Mason                                                  HEXACHLOROETHANE                                   DATE: 09/04/94       
EXPERIMENT: 05028 TEST: 01                                                                                     TIME: 09:45:11       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01CP9561904          ROUTE: GAVAGE                                                                      NTP C#: 04604B       
PATHOLOGIST: A. RUSSFIELD                                                                                      CAS: 67-72-1         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08    
LAB: Mason                                                  HEXACHLOROETHANE                                   DATE: 09/04/94      
EXPERIMENT: 05028 TEST: 01                                                                                     TIME: 09:45:11      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: N01CP9561904          ROUTE: GAVAGE                                                                      NTP C#: 04604B      
PATHOLOGIST: A. RUSSFIELD                                                                                      CAS: 67-72-1        
 
 
 
 
 
                                                    RATS(FISCHER344)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
 
 
                                                    ----------------
 
                                                    Adrenal Gland
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Epididymis
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Mason                                                  HEXACHLOROETHANE                                   DATE: 09/04/94       
EXPERIMENT: 05028 TEST: 01                                                                                     TIME: 09:45:11       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01CP9561904          ROUTE: GAVAGE                                                                      NTP C#: 04604B       
PATHOLOGIST: A. RUSSFIELD                                                                                      CAS: 67-72-1         
 
 
 
 
 
                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                        IN THE ANALYSIS OF THE STUDY OF HEXACHLOROETHANE
 
              ====================================================================================================
 
                                                           MALE RATS
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
 
                             Adrenal Medulla               Pheochromocytoma Benign
                                                           Pheochromocytoma: Benign, Complex, Malignant, NOS
                             Clitoral/Preputial Gland      Adenoma
                                                           Carcinoma or Adenoma
                             Kidney: Renal Tubule          Carcinoma
                                                           Carcinoma or Adenoma
                             Mammary Gland                 Fibroadenoma
                                                           Fibroma, Fibroadenoma, Carcinoma, or Adenoma
                             Pancreas                      Adenoma
 
              ====================================================================================================
 
                                                           FEMALE RATS
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
 
                             Adrenal Medulla               Pheochromocytoma: Benign, Complex, Malignant, NOS
                             Liver                         Hepatocellular Carcinoma or Hepatocellular Adenoma
                                                           Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
                             Pituitary Gland: Pars Distalis or Unspecified Site
                                                           Adenoma
                             All Organs                    Benign Tumors
                                                           Malignant and Benign Tumors
 
              ====================================================================================================
         DATE: 09/04/94                     EXPERIMENT: 05028 TEST: 01                                                 PAGE   1
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         .01G/KG         .02G/KG       |      VEHICLE         .08G/KG         .16G/KG       |
|                       |      MALE            LM              HM            |      FEMALE          LF              HF            |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    14/50 (28%)     26/45 (58%)     19/49 (39%)     |     1/50 (2%)       1/15 (7%)       2/46 (4%)      |
|ADJUSTED (b)           |     37.8%           76.1%           56.3%          |      3.1%           33.3%            6.3%          |
|TERMINAL (d)           |     9/31 (29%)     20/28 (71%)     12/26 (46%)     |     1/32 (3%)       1/3 (33%)       1/30 (3%)      |
|FIRST INCIDENCE (DAYS) |      637             578             577           |      731 (T)         731 (T)         727           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.064         P=0.006 **      P=0.091        |     P=0.378         P=0.200         P=0.489        |
|INCIDENTAL TUMOR       |     P=0.091         P=0.002 **      P=0.154        |     P=0.338         P=0.200         P=0.431        |
|LOGISTIC REGRESSION    |     P=0.089         P=0.002 **      P=0.133        |     P=0.377         P=0.200         P=0.481        |
|COCHRAN-ARMITAGE       |     P=0.158                                        |     P=0.362                                        |
|FISHER EXACT           |                     P=0.003 **      P=0.178        |                     P=0.411         P=0.468        |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Complex                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/45 (0%)       2/49 (4%)      |     0/50 (0%)       0/15 (0%)       0/46 (0%)      |
|ADJUSTED (b)           |      0.0%            0.0%            7.2%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/31 (0%)       0/28 (0%)       1/26 (4%)      |     0/32 (0%)       0/3 (0%)        0/30 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             703           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.080           (e)           P=0.204        |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.088           (e)           P=0.208        |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.085           (e)           P=0.212        |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.097                                        |       (e)                                          |
|FISHER EXACT           |                       (e)           P=0.242        |                       (e)             (e)          |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05028 TEST: 01                                                 PAGE   2
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         .01G/KG         .02G/KG       |      VEHICLE         .08G/KG         .16G/KG       |
|                       |      MALE            LM              HM            |      FEMALE          LF              HF            |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Malignant                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/50 (2%)       2/45 (4%)       1/49 (2%)      |     0/50 (0%)       1/15 (7%)       0/46 (0%)      |
|ADJUSTED (b)           |      3.2%            7.1%            3.8%          |      0.0%            2.8%            0.0%          |
|TERMINAL (d)           |     1/31 (3%)       2/28 (7%)       1/26 (4%)      |     0/32 (0%)       0/3 (0%)        0/30 (0%)      |
|FIRST INCIDENCE (DAYS) |      733 (T)         733 (T)         733 (T)       |      ---             660             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.566         P=0.464         P=0.723        |     P=0.718         P=0.484           (e)          |
|INCIDENTAL TUMOR       |     P=0.566         P=0.464         P=0.723        |     P=0.629         P=0.227           (e)          |
|LOGISTIC REGRESSION    |     P=0.566         P=0.464         P=0.723        |     P=0.704         P=0.280           (e)          |
|COCHRAN-ARMITAGE       |     P=0.614                                        |     P=0.692                                        |
|FISHER EXACT           |                     P=0.460         P=0.747        |                     P=0.231           (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    15/50 (30%)     28/45 (62%)     21/49 (43%)     |     1/50 (2%)       2/15 (13%)      2/46 (4%)      |
|ADJUSTED (b)           |     40.7%           82.1%           62.5%          |      3.1%           35.2%            6.3%          |
|TERMINAL (d)           |    10/31 (32%)     22/28 (79%)     14/26 (54%)     |     1/32 (3%)       1/3 (33%)       1/30 (3%)      |
|FIRST INCIDENCE (DAYS) |      637             578             577           |      731 (T)         660             727           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.038 *       P=0.003 **      P=0.058        |     P=0.383         P=0.090         P=0.489        |
|INCIDENTAL TUMOR       |     P=0.053         P<0.001 **      P=0.101        |     P=0.316         P=0.022 *       P=0.431        |
|LOGISTIC REGRESSION    |     P=0.051         P<0.001 **      P=0.086        |     P=0.367         P=0.028 *       P=0.481        |
|COCHRAN-ARMITAGE       |     P=0.115                                        |     P=0.369                                        |
|FISHER EXACT           |                     P=0.002 **      P=0.131        |                     P=0.131         P=0.468        |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05028 TEST: 01                                                 PAGE   3
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         .01G/KG         .02G/KG       |      VEHICLE         .08G/KG         .16G/KG       |
|                       |      MALE            LM              HM            |      FEMALE          LF              HF            |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/46 (2%)       2/17 (12%)      3/49 (6%)      |     3/46 (7%)       0/10 (0%)       2/39 (5%)      |
|ADJUSTED (b)           |      3.3%           35.4%           10.4%          |     10.3%            0.0%            6.7%          |
|TERMINAL (d)           |     1/30 (3%)       1/3 (33%)       2/25 (8%)      |     3/29 (10%)      0/2 (0%)        1/26 (4%)      |
|FIRST INCIDENCE (DAYS) |      733 (T)         708             630           |      731 (T)         ---             715           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.189         P=0.097         P=0.249        |     P=0.443N        P=0.772N        P=0.537N       |
|INCIDENTAL TUMOR       |     P=0.235         P=0.011 *       P=0.300        |     P=0.489N        P=0.772N        P=0.582N       |
|LOGISTIC REGRESSION    |     P=0.225         P=0.015 *       P=0.290        |     P=0.452N        P=0.772N        P=0.548N       |
|COCHRAN-ARMITAGE       |     P=0.271                                        |     P=0.474N                                       |
|FISHER EXACT           |                     P=0.175         P=0.333        |                     P=0.548N        P=0.579N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/46 (2%)       3/17 (18%)      4/49 (8%)      |     4/46 (9%)       1/10 (10%)      2/39 (5%)      |
|ADJUSTED (b)           |      3.3%           67.7%           12.5%          |     13.8%           50.0%            6.7%          |
|TERMINAL (d)           |     1/30 (3%)       2/3 (67%)       2/25 (8%)      |     4/29 (14%)      1/2 (50%)       1/26 (4%)      |
|FIRST INCIDENCE (DAYS) |      733 (T)         708             558           |      731 (T)         731 (T)         715           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.113         P=0.006 **      P=0.141        |     P=0.312N        P=0.364         P=0.377N       |
|INCIDENTAL TUMOR       |     P=0.157         P<0.001 **      P=0.205        |     P=0.351N        P=0.364         P=0.417N       |
|LOGISTIC REGRESSION    |     P=0.155         P<0.001 **      P=0.195        |     P=0.316N        P=0.364         P=0.381N       |
|COCHRAN-ARMITAGE       |     P=0.181                                        |     P=0.341N                                       |
|FISHER EXACT           |                     P=0.057         P=0.201        |                     P=0.641         P=0.420N       |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05028 TEST: 01                                                 PAGE   4
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         .01G/KG         .02G/KG       |      VEHICLE         .08G/KG         .16G/KG       |
|                       |      MALE            LM              HM            |      FEMALE          LF              HF            |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Schwannoma Malignant                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/50 (2%)       0/15 (0%)       0/50 (0%)      |     2/50 (4%)       0/11 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      3.2%            0.0%            0.0%          |      5.9%            0.0%            0.0%          |
|TERMINAL (d)           |     1/31 (3%)       0/2 (0%)        0/26 (0%)      |     1/32 (3%)       0/0             0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      733 (T)         ---             ---           |      693             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.336N        P=0.967N        P=0.535N       |     P=0.125N        P=0.531N        P=0.240N       |
|INCIDENTAL TUMOR       |     P=0.336N        P=0.967N        P=0.535N       |     P=0.174N        P=0.892N        P=0.291N       |
|LOGISTIC REGRESSION    |     P=0.336N        P=0.967N        P=0.535N       |     P=0.141N        P=0.875N        P=0.245N       |
|COCHRAN-ARMITAGE       |     P=0.295N                                       |     P=0.130N                                       |
|FISHER EXACT           |                     P=0.769N        P=0.500N       |                     P=0.669N        P=0.247N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       2/17 (12%)      0/50 (0%)      |     0/49 (0%)       0/11 (0%)       0/49 (0%)      |
|ADJUSTED (b)           |      6.5%           34.7%            0.0%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     2/31 (6%)       1/3 (33%)       0/26 (0%)      |     0/32 (0%)       0/0             0/31 (0%)      |
|FIRST INCIDENCE (DAYS) |      733 (T)         370             ---           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.249N        P=0.145         P=0.277N       |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.209N        P=0.143         P=0.277N       |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.198N        P=0.307         P=0.277N       |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.205N                                       |       (e)                                          |
|FISHER EXACT           |                     P=0.265         P=0.247N       |                       (e)             (e)          |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05028 TEST: 01                                                 PAGE   5
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         .01G/KG         .02G/KG       |      VEHICLE         .08G/KG         .16G/KG       |
|                       |      MALE            LM              HM            |      FEMALE          LF              HF            |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/17 (0%)       2/50 (4%)      |     0/49 (0%)       1/11 (9%)       0/49 (0%)      |
|ADJUSTED (b)           |      0.0%            0.0%            6.4%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/31 (0%)       0/3 (0%)        1/26 (4%)      |     0/32 (0%)       0/0             0/31 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             630           |      ---             660             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.101           (e)           P=0.207        |     P=0.718         P=0.484           (e)          |
|INCIDENTAL TUMOR       |     P=0.127           (e)           P=0.273        |     P=0.642         P=0.128           (e)          |
|LOGISTIC REGRESSION    |     P=0.121           (e)           P=0.234        |     P=0.698N        P=0.205           (e)          |
|COCHRAN-ARMITAGE       |     P=0.124                                        |     P=0.702                                        |
|FISHER EXACT           |                       (e)           P=0.247        |                     P=0.183           (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       2/17 (12%)      2/50 (4%)      |     0/49 (0%)       1/11 (9%)       0/49 (0%)      |
|ADJUSTED (b)           |      6.5%           34.7%            6.4%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     2/31 (6%)       1/3 (33%)       1/26 (4%)      |     0/32 (0%)       0/0             0/31 (0%)      |
|FIRST INCIDENCE (DAYS) |      733 (T)         370             630           |      ---             660             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.522         P=0.145         P=0.634        |     P=0.718         P=0.484           (e)          |
|INCIDENTAL TUMOR       |     P=0.576N        P=0.143         P=0.693        |     P=0.642         P=0.128           (e)          |
|LOGISTIC REGRESSION    |     P=0.587N        P=0.307         P=0.668        |     P=0.698N        P=0.205           (e)          |
|COCHRAN-ARMITAGE       |     P=0.590                                        |     P=0.702                                        |
|FISHER EXACT           |                     P=0.265         P=0.691N       |                     P=0.183           (e)          |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05028 TEST: 01                                                 PAGE   6
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         .01G/KG         .02G/KG       |      VEHICLE         .08G/KG         .16G/KG       |
|                       |      MALE            LM              HM            |      FEMALE          LF              HF            |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/50 (2%)       2/50 (4%)       4/50 (8%)      |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      2.6%            5.9%           15.4%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/31 (0%)       0/29 (0%)       4/26 (15%)     |     0/32 (0%)       0/27 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      654             677             733 (T)       |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.088         P=0.497         P=0.132        |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.087         P=0.457         P=0.135        |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.096         P=0.500         P=0.146        |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.118                                        |       (e)                                          |
|FISHER EXACT           |                     P=0.500         P=0.181        |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       3/50 (6%)      |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      0.0%            0.0%            9.2%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/31 (0%)       0/29 (0%)       1/26 (4%)      |     0/32 (0%)       0/27 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             636           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.030 *         (e)           P=0.098        |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.047 *         (e)           P=0.169        |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.037 *         (e)           P=0.121        |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.037 *                                      |       (e)                                          |
|FISHER EXACT           |                       (e)           P=0.121        |                       (e)             (e)          |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05028 TEST: 01                                                 PAGE   7
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         .01G/KG         .02G/KG       |      VEHICLE         .08G/KG         .16G/KG       |
|                       |      MALE            LM              HM            |      FEMALE          LF              HF            |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/50 (2%)       2/50 (4%)       7/50 (14%)     |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      2.6%            5.9%           23.7%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/31 (0%)       0/29 (0%)       5/26 (19%)     |     0/32 (0%)       0/27 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      654             677             636           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.009 **      P=0.497         P=0.020 *      |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.012 *       P=0.457         P=0.033 *      |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.011 *       P=0.500         P=0.026 *      |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.014 *                                      |       (e)                                          |
|FISHER EXACT           |                     P=0.500         P=0.030 *      |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/50 (2%)       1/31 (3%)       1/50 (2%)      |     1/50 (2%)       2/32 (6%)       1/50 (2%)      |
|ADJUSTED (b)           |      3.2%            7.7%            3.8%          |      3.1%           18.2%            2.8%          |
|TERMINAL (d)           |     1/31 (3%)       1/13 (8%)       1/26 (4%)      |     1/32 (3%)       2/11 (18%)      0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      733 (T)         733 (T)         733 (T)       |      731 (T)         731 (T)         692           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.574         P=0.557         P=0.723        |     P=0.608N        P=0.160         P=0.757N       |
|INCIDENTAL TUMOR       |     P=0.574         P=0.557         P=0.723        |     P=0.585         P=0.160         P=0.709        |
|LOGISTIC REGRESSION    |     P=0.574         P=0.557         P=0.723        |     P=0.605         P=0.160         P=0.755        |
|COCHRAN-ARMITAGE       |     P=0.631                                        |     P=0.615                                        |
|FISHER EXACT           |                     P=0.622         P=0.753N       |                     P=0.336         P=0.753N       |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05028 TEST: 01                                                 PAGE   8
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         .01G/KG         .02G/KG       |      VEHICLE         .08G/KG         .16G/KG       |
|                       |      MALE            LM              HM            |      FEMALE          LF              HF            |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       1/31 (3%)       2/50 (4%)      |     1/50 (2%)       3/32 (9%)       1/50 (2%)      |
|ADJUSTED (b)           |      5.5%            7.7%            7.2%          |      3.1%           27.3%            2.8%          |
|TERMINAL (d)           |     1/31 (3%)       1/13 (8%)       1/26 (4%)      |     1/32 (3%)       3/11 (27%)      0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      630             733 (T)         703           |      731 (T)         731 (T)         692           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.540         P=0.707N        P=0.635        |     P=0.597N        P=0.040 *       P=0.757N       |
|INCIDENTAL TUMOR       |     P=0.581         P=0.639N        P=0.691N       |     P=0.576         P=0.040 *       P=0.709        |
|LOGISTIC REGRESSION    |     P=0.569         P=0.700N        P=0.676        |     P=0.595         P=0.040 *       P=0.755        |
|COCHRAN-ARMITAGE       |     P=0.603                                        |     P=0.603N                                       |
|FISHER EXACT           |                     P=0.675N        P=0.691N       |                     P=0.162         P=0.753N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       1/31 (3%)       2/50 (4%)      |     1/50 (2%)       3/32 (9%)       1/50 (2%)      |
|ADJUSTED (b)           |      5.5%            7.7%            7.2%          |      3.1%           27.3%            2.8%          |
|TERMINAL (d)           |     1/31 (3%)       1/13 (8%)       1/26 (4%)      |     1/32 (3%)       3/11 (27%)      0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      630             733 (T)         703           |      731 (T)         731 (T)         692           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.540         P=0.707N        P=0.635        |     P=0.597N        P=0.040 *       P=0.757N       |
|INCIDENTAL TUMOR       |     P=0.581         P=0.639N        P=0.691N       |     P=0.576         P=0.040 *       P=0.709        |
|LOGISTIC REGRESSION    |     P=0.569         P=0.700N        P=0.676        |     P=0.595         P=0.040 *       P=0.755        |
|COCHRAN-ARMITAGE       |     P=0.603                                        |     P=0.603N                                       |
|FISHER EXACT           |                     P=0.675N        P=0.691N       |                     P=0.162         P=0.753N       |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05028 TEST: 01                                                 PAGE   9
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         .01G/KG         .02G/KG       |      VEHICLE         .08G/KG         .16G/KG       |
|                       |      MALE            LM              HM            |      FEMALE          LF              HF            |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     4/50 (8%)       0/24 (0%)       2/50 (4%)      |     2/50 (4%)       0/29 (0%)       1/50 (2%)      |
|ADJUSTED (b)           |     11.5%            0.0%            6.5%          |      6.3%            0.0%            3.0%          |
|TERMINAL (d)           |     2/31 (6%)       0/6 (0%)        1/26 (4%)      |     2/32 (6%)       0/13 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      646             ---             636           |      731 (T)         ---             727           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.307N        P=0.185N        P=0.424N       |     P=0.369N        P=0.451N        P=0.496N       |
|INCIDENTAL TUMOR       |     P=0.270N        P=0.258N        P=0.358N       |     P=0.411N        P=0.451N        P=0.554N       |
|LOGISTIC REGRESSION    |     P=0.271N        P=0.257N        P=0.361N       |     P=0.371N        P=0.451N        P=0.497N       |
|COCHRAN-ARMITAGE       |     P=0.242N                                       |     P=0.370N                                       |
|FISHER EXACT           |                     P=0.200N        P=0.339N       |                     P=0.398N        P=0.500N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     4/50 (8%)       0/24 (0%)       2/50 (4%)      |     2/50 (4%)       0/29 (0%)       2/50 (4%)      |
|ADJUSTED (b)           |     11.5%            0.0%            6.5%          |      6.3%            0.0%            6.1%          |
|TERMINAL (d)           |     2/31 (6%)       0/6 (0%)        1/26 (4%)      |     2/32 (6%)       0/13 (0%)       1/32 (3%)      |
|FIRST INCIDENCE (DAYS) |      646             ---             636           |      731 (T)         ---             727           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.307N        P=0.185N        P=0.424N       |     P=0.609N        P=0.451N        P=0.691N       |
|INCIDENTAL TUMOR       |     P=0.270N        P=0.258N        P=0.358N       |     P=0.577         P=0.451N        P=0.652        |
|LOGISTIC REGRESSION    |     P=0.271N        P=0.257N        P=0.361N       |     P=0.607N        P=0.451N        P=0.693N       |
|COCHRAN-ARMITAGE       |     P=0.242N                                       |     P=0.613N                                       |
|FISHER EXACT           |                     P=0.200N        P=0.339N       |                     P=0.398N        P=0.691N       |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05028 TEST: 01                                                 PAGE  10
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         .01G/KG         .02G/KG       |      VEHICLE         .08G/KG         .16G/KG       |
|                       |      MALE            LM              HM            |      FEMALE          LF              HF            |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     7/50 (14%)      6/50 (12%)      1/50 (2%)      |    28/50 (56%)     21/50 (42%)     24/50 (48%)     |
|ADJUSTED (b)           |     20.6%           19.0%            3.8%          |     67.8%           55.1%           60.6%          |
|TERMINAL (d)           |     5/31 (16%)      4/29 (14%)      1/26 (4%)      |    19/32 (59%)     11/27 (41%)     17/32 (53%)     |
|FIRST INCIDENCE (DAYS) |      630             684             733 (T)       |      552             503             450           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.053N        P=0.550N        P=0.057N       |     P=0.293N        P=0.321N        P=0.316N       |
|INCIDENTAL TUMOR       |     P=0.043N*       P=0.527N        P=0.043N*      |     P=0.255N        P=0.117N        P=0.302N       |
|LOGISTIC REGRESSION    |     P=0.042N*       P=0.519N        P=0.045N*      |     P=0.269N        P=0.133N        P=0.312N       |
|COCHRAN-ARMITAGE       |     P=0.029N*                                      |     P=0.242N                                       |
|FISHER EXACT           |                     P=0.500N        P=0.030N*      |                     P=0.115N        P=0.274N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     8/50 (16%)      6/50 (12%)      2/50 (4%)      |    28/50 (56%)     21/50 (42%)     24/50 (48%)     |
|ADJUSTED (b)           |     23.7%           19.0%            7.7%          |     67.8%           55.1%           60.6%          |
|TERMINAL (d)           |     6/31 (19%)      4/29 (14%)      2/26 (8%)      |    19/32 (59%)     11/27 (41%)     17/32 (53%)     |
|FIRST INCIDENCE (DAYS) |      630             684             733 (T)       |      552             503             450           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.068N        P=0.439N        P=0.083N       |     P=0.293N        P=0.321N        P=0.316N       |
|INCIDENTAL TUMOR       |     P=0.057N        P=0.415N        P=0.066N       |     P=0.255N        P=0.117N        P=0.302N       |
|LOGISTIC REGRESSION    |     P=0.055N        P=0.405N        P=0.069N       |     P=0.269N        P=0.133N        P=0.312N       |
|COCHRAN-ARMITAGE       |     P=0.037N*                                      |     P=0.242N                                       |
|FISHER EXACT           |                     P=0.387N        P=0.046N*      |                     P=0.115N        P=0.274N       |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05028 TEST: 01                                                 PAGE  11
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         .01G/KG         .02G/KG       |      VEHICLE         .08G/KG         .16G/KG       |
|                       |      MALE            LM              HM            |      FEMALE          LF              HF            |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip)                                                                           |
|     Papilloma Squamous or Papilloma                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       2/50 (4%)       1/50 (2%)      |     0/50 (0%)       1/50 (2%)       1/50 (2%)      |
|ADJUSTED (b)           |      0.0%            6.9%            2.9%          |      0.0%            3.7%            2.5%          |
|TERMINAL (d)           |     0/31 (0%)       2/29 (7%)       0/26 (0%)      |     0/32 (0%)       1/27 (4%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             733 (T)         649           |      ---             731 (T)         630           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.321         P=0.223         P=0.478        |     P=0.332         P=0.466         P=0.495        |
|INCIDENTAL TUMOR       |     P=0.321         P=0.223         P=0.477        |     P=0.336         P=0.466         P=0.500        |
|LOGISTIC REGRESSION    |     P=0.341         P=0.223         P=0.504        |     P=0.335         P=0.466         P=0.553        |
|COCHRAN-ARMITAGE       |     P=0.360                                        |     P=0.331                                        |
|FISHER EXACT           |                     P=0.247         P=0.500        |                     P=0.500         P=0.500        |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip)                                                                           |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       2/50 (4%)       1/50 (2%)      |     0/50 (0%)       1/50 (2%)       1/50 (2%)      |
|ADJUSTED (b)           |      0.0%            6.9%            2.9%          |      0.0%            3.7%            2.5%          |
|TERMINAL (d)           |     0/31 (0%)       2/29 (7%)       0/26 (0%)      |     0/32 (0%)       1/27 (4%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             733 (T)         649           |      ---             731 (T)         630           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.321         P=0.223         P=0.478        |     P=0.332         P=0.466         P=0.495        |
|INCIDENTAL TUMOR       |     P=0.321         P=0.223         P=0.477        |     P=0.336         P=0.466         P=0.500        |
|LOGISTIC REGRESSION    |     P=0.341         P=0.223         P=0.504        |     P=0.335         P=0.466         P=0.553        |
|COCHRAN-ARMITAGE       |     P=0.360                                        |     P=0.331                                        |
|FISHER EXACT           |                     P=0.247         P=0.500        |                     P=0.500         P=0.500        |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05028 TEST: 01                                                 PAGE  12
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         .01G/KG         .02G/KG       |      VEHICLE         .08G/KG         .16G/KG       |
|                       |      MALE            LM              HM            |      FEMALE          LF              HF            |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       4/18 (22%)      0/50 (0%)      |     0/48 (0%)       0/12 (0%)       0/49 (0%)      |
|ADJUSTED (b)           |      0.0%           75.6%            0.0%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/31 (0%)       3/4 (75%)       0/26 (0%)      |     0/32 (0%)       0/0             0/31 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             617             ---           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.546         P<0.001 **        (e)          |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.590         P<0.001 **        (e)          |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.577         P<0.001 **        (e)          |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.609                                        |       (e)                                          |
|FISHER EXACT           |                     P=0.004 **        (e)          |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    24/49 (49%)     22/50 (44%)     16/48 (33%)     |    26/50 (52%)     20/49 (41%)     16/49 (33%)     |
|ADJUSTED (b)           |     62.5%           55.3%           49.4%          |     63.0%           55.7%           43.4%          |
|TERMINAL (d)           |    17/31 (55%)     12/29 (41%)     10/25 (40%)     |    17/32 (53%)     12/27 (44%)     12/32 (38%)     |
|FIRST INCIDENCE (DAYS) |      568             559             472           |      506             616             575           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.243N        P=0.517N        P=0.265N       |     P=0.047N*       P=0.373N        P=0.051N       |
|INCIDENTAL TUMOR       |     P=0.095N        P=0.403N        P=0.121N       |     P=0.043N*       P=0.143N        P=0.054N       |
|LOGISTIC REGRESSION    |     P=0.099N        P=0.405N        P=0.121N       |     P=0.036N*       P=0.214N        P=0.046N*      |
|COCHRAN-ARMITAGE       |     P=0.073N                                       |     P=0.032N*                                      |
|FISHER EXACT           |                     P=0.384N        P=0.087N       |                     P=0.180N        P=0.040N*      |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05028 TEST: 01                                                 PAGE  13
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         .01G/KG         .02G/KG       |      VEHICLE         .08G/KG         .16G/KG       |
|                       |      MALE            LM              HM            |      FEMALE          LF              HF            |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    24/49 (49%)     22/50 (44%)     16/48 (33%)     |    26/50 (52%)     20/49 (41%)     17/49 (35%)     |
|ADJUSTED (b)           |     62.5%           55.3%           49.4%          |     63.0%           55.7%           45.0%          |
|TERMINAL (d)           |    17/31 (55%)     12/29 (41%)     10/25 (40%)     |    17/32 (53%)     12/27 (44%)     12/32 (38%)     |
|FIRST INCIDENCE (DAYS) |      568             559             472           |      506             616             575           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.243N        P=0.517N        P=0.265N       |     P=0.069N        P=0.373N        P=0.077N       |
|INCIDENTAL TUMOR       |     P=0.095N        P=0.403N        P=0.121N       |     P=0.069N        P=0.143N        P=0.086N       |
|LOGISTIC REGRESSION    |     P=0.099N        P=0.405N        P=0.121N       |     P=0.057N        P=0.214N        P=0.070N       |
|COCHRAN-ARMITAGE       |     P=0.073N                                       |     P=0.050N                                       |
|FISHER EXACT           |                     P=0.384N        P=0.087N       |                     P=0.180N        P=0.062N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     6/50 (12%)      5/50 (10%)      5/50 (10%)     |     0/50 (0%)       1/50 (2%)       0/50 (0%)      |
|ADJUSTED (b)           |     18.3%           15.1%           17.5%          |      0.0%            2.1%            0.0%          |
|TERMINAL (d)           |     5/31 (16%)      3/29 (10%)      4/26 (15%)     |     0/32 (0%)       0/27 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      654             559             587           |      ---             548             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.548N        P=0.536N        P=0.617N       |     P=0.722         P=0.496           (e)          |
|INCIDENTAL TUMOR       |     P=0.496N        P=0.517N        P=0.577N       |     P=0.726         P=0.477           (e)          |
|LOGISTIC REGRESSION    |     P=0.487N        P=0.506N        P=0.567N       |     P=0.641N        P=0.652           (e)          |
|COCHRAN-ARMITAGE       |     P=0.436N                                       |     P=0.731                                        |
|FISHER EXACT           |                     P=0.500N        P=0.500N       |                     P=0.500           (e)          |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05028 TEST: 01                                                 PAGE  14
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         .01G/KG         .02G/KG       |      VEHICLE         .08G/KG         .16G/KG       |
|                       |      MALE            LM              HM            |      FEMALE          LF              HF            |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       1/50 (2%)       1/50 (2%)      |     1/50 (2%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      5.6%            2.3%            2.4%          |      3.1%            0.0%            0.0%          |
|TERMINAL (d)           |     1/31 (3%)       0/29 (0%)       0/26 (0%)      |     1/32 (3%)       0/27 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      646             614             586           |      731 (T)         ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.421N        P=0.517N        P=0.547N       |     P=0.276N        P=0.534N        P=0.500N       |
|INCIDENTAL TUMOR       |     P=0.326N        P=0.463N        P=0.476N       |     P=0.276N        P=0.534N        P=0.500N       |
|LOGISTIC REGRESSION    |     P=0.372N        P=0.503N        P=0.494N       |     P=0.276N        P=0.534N        P=0.500N       |
|COCHRAN-ARMITAGE       |     P=0.378N                                       |     P=0.269N                                       |
|FISHER EXACT           |                     P=0.500N        P=0.500N       |                     P=0.500N        P=0.500N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Trichoepithelioma, Basal Cell Carcinoma, or Basal Cell Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/50 (2%)       2/50 (4%)       0/50 (0%)      |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      3.2%            6.9%            0.0%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     1/31 (3%)       2/29 (7%)       0/26 (0%)      |     0/32 (0%)       0/27 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      733 (T)         733 (T)         ---           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.407N        P=0.477         P=0.535N       |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.407N        P=0.477         P=0.535N       |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.407N        P=0.477         P=0.535N       |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.360N                                       |       (e)                                          |
|FISHER EXACT           |                     P=0.500         P=0.500N       |                       (e)             (e)          |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05028 TEST: 01                                                 PAGE  15
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         .01G/KG         .02G/KG       |      VEHICLE         .08G/KG         .16G/KG       |
|                       |      MALE            LM              HM            |      FEMALE          LF              HF            |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma,                                                                |
|     Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     9/50 (18%)      8/50 (16%)      6/50 (12%)     |     1/50 (2%)       1/50 (2%)       0/50 (0%)      |
|ADJUSTED (b)           |     26.5%           23.4%           19.5%          |      3.1%            2.1%            0.0%          |
|TERMINAL (d)           |     7/31 (23%)      5/29 (17%)      4/26 (15%)     |     1/32 (3%)       0/27 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      646             559             586           |      731 (T)         548             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.363N        P=0.547N        P=0.414N       |     P=0.341N        P=0.739         P=0.500N       |
|INCIDENTAL TUMOR       |     P=0.281N        P=0.508N        P=0.345N       |     P=0.336N        P=0.728         P=0.500N       |
|LOGISTIC REGRESSION    |     P=0.277N        P=0.504N        P=0.331N       |     P=0.286N        P=0.726N        P=0.500N       |
|COCHRAN-ARMITAGE       |     P=0.244N                                       |     P=0.331N                                       |
|FISHER EXACT           |                     P=0.500N        P=0.288N       |                     P=0.753N        P=0.500N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     6/50 (12%)      3/50 (6%)       2/50 (4%)      |     1/50 (2%)       2/50 (4%)       1/50 (2%)      |
|ADJUSTED (b)           |     17.2%            8.3%            7.4%          |      2.3%            5.9%            3.1%          |
|TERMINAL (d)           |     4/31 (13%)      1/29 (3%)       1/26 (4%)      |     0/32 (0%)       1/27 (4%)       1/32 (3%)      |
|FIRST INCIDENCE (DAYS) |      568             617             724           |      623             612             731 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.134N        P=0.269N        P=0.195N       |     P=0.614         P=0.478         P=0.758        |
|INCIDENTAL TUMOR       |     P=0.099N        P=0.221N        P=0.161N       |     P=0.619N        P=0.452         P=0.760        |
|LOGISTIC REGRESSION    |     P=0.097N        P=0.242N        P=0.154N       |     P=0.610N        P=0.543         P=0.756N       |
|COCHRAN-ARMITAGE       |     P=0.090N                                       |     P=0.622N                                       |
|FISHER EXACT           |                     P=0.243N        P=0.134N       |                     P=0.500         P=0.753N       |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05028 TEST: 01                                                 PAGE  16
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         .01G/KG         .02G/KG       |      VEHICLE         .08G/KG         .16G/KG       |
|                       |      MALE            LM              HM            |      FEMALE          LF              HF            |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/50 (4%)       3/50 (6%)       2/50 (4%)      |     0/50 (0%)       0/50 (0%)       1/50 (2%)      |
|ADJUSTED (b)           |      5.6%            7.4%            7.2%          |      0.0%            0.0%            2.5%          |
|TERMINAL (d)           |     1/31 (3%)       1/29 (3%)       1/26 (4%)      |     0/32 (0%)       0/27 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      646             370             703           |      ---             ---             630           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.535         P=0.485         P=0.631        |     P=0.266           (e)           P=0.495        |
|INCIDENTAL TUMOR       |     P=0.566N        P=0.522         P=0.641        |     P=0.274           (e)           P=0.500        |
|LOGISTIC REGRESSION    |     P=0.583N        P=0.466         P=0.672        |     P=0.295           (e)           P=0.553        |
|COCHRAN-ARMITAGE       |     P=0.594                                        |     P=0.269                                        |
|FISHER EXACT           |                     P=0.500         P=0.691N       |                       (e)           P=0.500        |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Neurofibrosarcoma, Fibrosarcoma, Sarcoma,                                                                                   |
|     Neurofibroma, or Fibroma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     8/50 (16%)      6/50 (12%)      4/50 (8%)      |     1/50 (2%)       2/50 (4%)       2/50 (4%)      |
|ADJUSTED (b)           |     22.2%           15.3%           14.2%          |      2.3%            5.9%            5.5%          |
|TERMINAL (d)           |     5/31 (16%)      2/29 (7%)       2/26 (8%)      |     0/32 (0%)       1/27 (4%)       1/32 (3%)      |
|FIRST INCIDENCE (DAYS) |      568             370             703           |      623             612             630           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.217N        P=0.421N        P=0.271N       |     P=0.386         P=0.478         P=0.494        |
|INCIDENTAL TUMOR       |     P=0.141N        P=0.351N        P=0.228N       |     P=0.392         P=0.452         P=0.500        |
|LOGISTIC REGRESSION    |     P=0.139N        P=0.395N        P=0.208N       |     P=0.416         P=0.543         P=0.535        |
|COCHRAN-ARMITAGE       |     P=0.141N                                       |     P=0.390                                        |
|FISHER EXACT           |                     P=0.387N        P=0.178N       |                     P=0.500         P=0.500        |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05028 TEST: 01                                                 PAGE  17
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         .01G/KG         .02G/KG       |      VEHICLE         .08G/KG         .16G/KG       |
|                       |      MALE            LM              HM            |      FEMALE          LF              HF            |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    43/49 (88%)     41/46 (89%)     45/50 (90%)     |                                                    |
|ADJUSTED (b)           |     93.4%          100.0%           97.8%          |                                                    |
|TERMINAL (d)           |    28/31 (90%)     27/27 (100%)    25/26 (96%)     |                                                    |
|FIRST INCIDENCE (DAYS) |      406             489             467           |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.085         P=0.416         P=0.111        |                                                    |
|INCIDENTAL TUMOR       |     P=0.221         P=0.543         P=0.341        |                                                    |
|LOGISTIC REGRESSION    |     P=0.250         P=0.506         P=0.362        |                                                    |
|COCHRAN-ARMITAGE       |     P=0.422                                        |                                                    |
|FISHER EXACT           |                     P=0.545         P=0.486        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Thymoma Benign                                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/47 (0%)       0/11 (0%)       2/43 (5%)      |     0/41 (0%)       0/11 (0%)       0/45 (0%)      |
|ADJUSTED (b)           |      0.0%            0.0%            8.7%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/29 (0%)       0/0             2/23 (9%)      |     0/24 (0%)       0/0             0/28 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             733 (T)       |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.107           (e)           P=0.188        |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.107           (e)           P=0.188        |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.107           (e)           P=0.188        |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.116                                        |       (e)                                          |
|FISHER EXACT           |                       (e)           P=0.225        |                       (e)             (e)          |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05028 TEST: 01                                                 PAGE  18
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         .01G/KG         .02G/KG       |      VEHICLE         .08G/KG         .16G/KG       |
|                       |      MALE            LM              HM            |      FEMALE          LF              HF            |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     6/49 (12%)      9/50 (18%)      5/50 (10%)     |     9/50 (18%)      7/50 (14%)      6/50 (12%)     |
|ADJUSTED (b)           |     17.8%           27.3%           15.8%          |     24.2%           22.1%           17.8%          |
|TERMINAL (d)           |     4/31 (13%)      6/29 (21%)      3/26 (12%)     |     5/32 (16%)      4/27 (15%)      5/32 (16%)     |
|FIRST INCIDENCE (DAYS) |      667             644             472           |      618             660             643           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.549         P=0.255         P=0.607N       |     P=0.260N        P=0.507N        P=0.303N       |
|INCIDENTAL TUMOR       |     P=0.483N        P=0.257         P=0.519N       |     P=0.292N        P=0.360N        P=0.335N       |
|LOGISTIC REGRESSION    |     P=0.485N        P=0.272         P=0.520N       |     P=0.262N        P=0.427N        P=0.311N       |
|COCHRAN-ARMITAGE       |     P=0.426N                                       |     P=0.240N                                       |
|FISHER EXACT           |                     P=0.303         P=0.486N       |                     P=0.393N        P=0.288N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/49 (6%)       2/50 (4%)       0/50 (0%)      |     1/50 (2%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      8.4%            5.7%            0.0%          |      3.1%            0.0%            0.0%          |
|TERMINAL (d)           |     1/31 (3%)       1/29 (3%)       0/26 (0%)      |     1/32 (3%)       0/27 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      630             614             ---           |      731 (T)         ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.109N        P=0.532N        P=0.156N       |     P=0.276N        P=0.534N        P=0.500N       |
|INCIDENTAL TUMOR       |     P=0.067N        P=0.431N        P=0.109N       |     P=0.276N        P=0.534N        P=0.500N       |
|LOGISTIC REGRESSION    |     P=0.081N        P=0.492N        P=0.126N       |     P=0.276N        P=0.534N        P=0.500N       |
|COCHRAN-ARMITAGE       |     P=0.079N                                       |     P=0.269N                                       |
|FISHER EXACT           |                     P=0.490N        P=0.117N       |                     P=0.500N        P=0.500N       |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05028 TEST: 01                                                 PAGE  19
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         .01G/KG         .02G/KG       |      VEHICLE         .08G/KG         .16G/KG       |
|                       |      MALE            LM              HM            |      FEMALE          LF              HF            |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     9/49 (18%)     11/50 (22%)      5/50 (10%)     |    10/50 (20%)      7/50 (14%)      6/50 (12%)     |
|ADJUSTED (b)           |     25.1%           32.1%           15.8%          |     27.0%           22.1%           17.8%          |
|TERMINAL (d)           |     5/31 (16%)      7/29 (24%)      3/26 (12%)     |     6/32 (19%)      4/27 (15%)      5/32 (16%)     |
|FIRST INCIDENCE (DAYS) |      630             614             472           |      618             660             643           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.288N        P=0.352         P=0.300N       |     P=0.185N        P=0.414N        P=0.221N       |
|INCIDENTAL TUMOR       |     P=0.188N        P=0.406         P=0.199N       |     P=0.208N        P=0.276N        P=0.246N       |
|LOGISTIC REGRESSION    |     P=0.198N        P=0.394         P=0.208N       |     P=0.184N        P=0.333N        P=0.227N       |
|COCHRAN-ARMITAGE       |     P=0.162N                                       |     P=0.166N                                       |
|FISHER EXACT           |                     P=0.421         P=0.183N       |                     P=0.298N        P=0.207N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/49 (2%)       0/50 (0%)       2/50 (4%)      |     0/50 (0%)       0/50 (0%)       2/50 (4%)      |
|ADJUSTED (b)           |      3.1%            0.0%            7.4%          |      0.0%            0.0%            6.3%          |
|TERMINAL (d)           |     0/31 (0%)       0/29 (0%)       1/26 (4%)      |     0/32 (0%)       0/27 (0%)       2/32 (6%)      |
|FIRST INCIDENCE (DAYS) |      726             ---             724           |      ---             ---             731 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.314         P=0.520N        P=0.436        |     P=0.102           (e)           P=0.238        |
|INCIDENTAL TUMOR       |     P=0.324         P=0.523N        P=0.452        |     P=0.102           (e)           P=0.238        |
|LOGISTIC REGRESSION    |     P=0.320         P=0.507N        P=0.447        |     P=0.102           (e)           P=0.238        |
|COCHRAN-ARMITAGE       |     P=0.366                                        |     P=0.095                                        |
|FISHER EXACT           |                     P=0.495N        P=0.508        |                       (e)           P=0.247        |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05028 TEST: 01                                                 PAGE  20
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         .01G/KG         .02G/KG       |      VEHICLE         .08G/KG         .16G/KG       |
|                       |      MALE            LM              HM            |      FEMALE          LF              HF            |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/49 (2%)       1/50 (2%)       2/50 (4%)      |     0/50 (0%)       1/50 (2%)       2/50 (4%)      |
|ADJUSTED (b)           |      3.1%            2.5%            7.4%          |      0.0%            3.7%            6.3%          |
|TERMINAL (d)           |     0/31 (0%)       0/29 (0%)       1/26 (4%)      |     0/32 (0%)       1/27 (4%)       2/32 (6%)      |
|FIRST INCIDENCE (DAYS) |      726             623             724           |      ---             731 (T)         731 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.328         P=0.741         P=0.436        |     P=0.148         P=0.466         P=0.238        |
|INCIDENTAL TUMOR       |     P=0.381         P=0.720N        P=0.452        |     P=0.148         P=0.466         P=0.238        |
|LOGISTIC REGRESSION    |     P=0.360         P=0.756N        P=0.447        |     P=0.148         P=0.466         P=0.238        |
|COCHRAN-ARMITAGE       |     P=0.384                                        |     P=0.142                                        |
|FISHER EXACT           |                     P=0.747N        P=0.508        |                     P=0.500         P=0.247        |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |    10/50 (20%)      7/50 (14%)      5/50 (10%)     |
|ADJUSTED (b)           |                                                    |     28.7%           20.7%           13.5%          |
|TERMINAL (d)           |                                                    |     8/32 (25%)      3/27 (11%)      2/32 (6%)      |
|FIRST INCIDENCE (DAYS) |                                                    |      585             503             588           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |     P=0.120N        P=0.415N        P=0.143N       |
|INCIDENTAL TUMOR       |                                                    |     P=0.112N        P=0.271N        P=0.178N       |
|LOGISTIC REGRESSION    |                                                    |     P=0.109N        P=0.316N        P=0.144N       |
|COCHRAN-ARMITAGE       |                                                    |     P=0.102N                                       |
|FISHER EXACT           |                                                    |                     P=0.298N        P=0.131N       |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05028 TEST: 01                                                 PAGE  21
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         .01G/KG         .02G/KG       |      VEHICLE         .08G/KG         .16G/KG       |
|                       |      MALE            LM              HM            |      FEMALE          LF              HF            |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |    11/50 (22%)      7/50 (14%)      5/50 (10%)     |
|ADJUSTED (b)           |                                                    |     30.4%           20.7%           13.5%          |
|TERMINAL (d)           |                                                    |     8/32 (25%)      3/27 (11%)      2/32 (6%)      |
|FIRST INCIDENCE (DAYS) |                                                    |      585             503             588           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |     P=0.081N        P=0.326N        P=0.101N       |
|INCIDENTAL TUMOR       |                                                    |     P=0.073N        P=0.178N        P=0.132N       |
|LOGISTIC REGRESSION    |                                                    |     P=0.068N        P=0.229N        P=0.095N       |
|COCHRAN-ARMITAGE       |                                                    |     P=0.063N                                       |
|FISHER EXACT           |                                                    |                     P=0.218N        P=0.086N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/50 (2%)       0/50 (0%)       0/50 (0%)      |     2/50 (4%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      2.5%            0.0%            0.0%          |      5.3%            0.0%            0.0%          |
|TERMINAL (d)           |     0/31 (0%)       0/29 (0%)       0/26 (0%)      |     1/32 (3%)       0/27 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      646             ---             ---           |      609             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.292N        P=0.516N        P=0.532N       |     P=0.103N        P=0.261N        P=0.247N       |
|INCIDENTAL TUMOR       |     P=0.288N        P=0.523N        P=0.523N       |     P=0.102N        P=0.272N        P=0.240N       |
|LOGISTIC REGRESSION    |     P=0.268N        P=0.506N        P=0.496N       |     P=0.087N        P=0.220N        P=0.220N       |
|COCHRAN-ARMITAGE       |     P=0.269N                                       |     P=0.095N                                       |
|FISHER EXACT           |                     P=0.500N        P=0.500N       |                     P=0.247N        P=0.247N       |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05028 TEST: 01                                                 PAGE  22
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         .01G/KG         .02G/KG       |      VEHICLE         .08G/KG         .16G/KG       |
|                       |      MALE            LM              HM            |      FEMALE          LF              HF            |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear,                                                                              |
|     or Undifferentiated                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    13/50 (26%)     15/50 (30%)     11/50 (22%)     |    19/50 (38%)     12/50 (24%)     15/50 (30%)     |
|ADJUSTED (b)           |     34.3%           38.8%           31.1%          |     45.8%           31.4%           35.9%          |
|TERMINAL (d)           |     8/31 (26%)      7/29 (24%)      5/26 (19%)     |    11/32 (34%)      4/27 (15%)      6/32 (19%)     |
|FIRST INCIDENCE (DAYS) |      530             489             483           |      585             566             588           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.527N        P=0.372         P=0.558N       |     P=0.277N        P=0.207N        P=0.311N       |
|INCIDENTAL TUMOR       |     P=0.323N        P=0.447         P=0.359N       |     P=0.296N        P=0.097N        P=0.340N       |
|LOGISTIC REGRESSION    |     P=0.368N        P=0.413         P=0.408N       |     P=0.349N        P=0.081N        P=0.434N       |
|COCHRAN-ARMITAGE       |     P=0.366N                                       |     P=0.224N                                       |
|FISHER EXACT           |                     P=0.412         P=0.408N       |                     P=0.097N        P=0.263N       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma And Histiocytic Sarcoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |     0/50 (0%)       0/50 (0%)       2/50 (4%)      |
|ADJUSTED (b)           |      0.0%            0.0%            0.0%          |      0.0%            0.0%            5.5%          |
|TERMINAL (d)           |     0/31 (0%)       0/29 (0%)       0/26 (0%)      |     0/32 (0%)       0/27 (0%)       1/32 (3%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             ---           |      ---             ---             628           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |       (e)             (e)             (e)          |     P=0.100           (e)           P=0.240        |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.102           (e)           P=0.240        |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.096           (e)           P=0.242        |
|COCHRAN-ARMITAGE       |       (e)                                          |     P=0.095                                        |
|FISHER EXACT           |                       (e)             (e)          |                       (e)           P=0.247        |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05028 TEST: 01                                                 PAGE  23
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         .01G/KG         .02G/KG       |      VEHICLE         .08G/KG         .16G/KG       |
|                       |      MALE            LM              HM            |      FEMALE          LF              HF            |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        |
|     NOS, or Undifferentiated Cell Type                                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |     0/50 (0%)       0/50 (0%)       2/50 (4%)      |
|ADJUSTED (b)           |      0.0%            0.0%            0.0%          |      0.0%            0.0%            5.5%          |
|TERMINAL (d)           |     0/31 (0%)       0/29 (0%)       0/26 (0%)      |     0/32 (0%)       0/27 (0%)       1/32 (3%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             ---           |      ---             ---             628           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |       (e)             (e)             (e)          |     P=0.100           (e)           P=0.240        |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.102           (e)           P=0.240        |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.096           (e)           P=0.242        |
|COCHRAN-ARMITAGE       |       (e)                                          |     P=0.095                                        |
|FISHER EXACT           |                       (e)             (e)          |                       (e)           P=0.247        |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma Benign, Malignant, NOS                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/50 (2%)       3/50 (6%)       5/50 (10%)     |     0/50 (0%)       0/50 (0%)       0/50 (0%)      |
|ADJUSTED (b)           |      3.2%            8.6%           14.5%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     1/31 (3%)       0/29 (0%)       2/26 (8%)      |     0/32 (0%)       0/27 (0%)       0/32 (0%)      |
|FIRST INCIDENCE (DAYS) |      733 (T)         614             467           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.056         P=0.296         P=0.086        |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.092         P=0.322         P=0.124        |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.073         P=0.305         P=0.107        |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.070                                        |       (e)                                          |
|FISHER EXACT           |                     P=0.309         P=0.102        |                       (e)             (e)          |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05028 TEST: 01                                                 PAGE  24
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         .01G/KG         .02G/KG       |      VEHICLE         .08G/KG         .16G/KG       |
|                       |      MALE            LM              HM            |      FEMALE          LF              HF            |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    48/50 (96%)     49/50 (98%)     48/50 (96%)     |    44/50 (88%)     36/50 (72%)     40/50 (80%)     |
|ADJUSTED (b)           |    100.0%          100.0%          100.0%          |     95.6%           83.3%           88.7%          |
|TERMINAL (d)           |    31/31 (100%)    29/29 (100%)    26/26 (100%)    |    30/32 (94%)     20/27 (74%)     27/32 (84%)     |
|FIRST INCIDENCE (DAYS) |      406             370             467           |      506             503             450           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.139         P=0.339         P=0.160        |     P=0.317N        P=0.393N        P=0.330N       |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.239N        P=0.043N*       P=0.264N       |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.258N        P=0.056N        P=0.293N       |
|COCHRAN-ARMITAGE       |     P=0.610                                        |     P=0.191N                                       |
|FISHER EXACT           |                     P=0.500         P=0.691N       |                     P=0.039N*       P=0.207N       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    24/50 (48%)     22/50 (44%)     22/50 (44%)     |    22/50 (44%)     16/50 (32%)     20/50 (40%)     |
|ADJUSTED (b)           |     59.0%           52.2%           57.8%          |     50.8%           39.0%           46.5%          |
|TERMINAL (d)           |    15/31 (48%)     10/29 (34%)     11/26 (42%)     |    12/32 (38%)      5/27 (19%)      9/32 (28%)     |
|FIRST INCIDENCE (DAYS) |      530             370             483           |      585             396             588           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.445         P=0.507N        P=0.469        |     P=0.430N        P=0.299N        P=0.458N       |
|INCIDENTAL TUMOR       |     P=0.341N        P=0.374N        P=0.411N       |     P=0.483N        P=0.116N        P=0.573N       |
|LOGISTIC REGRESSION    |     P=0.397N        P=0.419N        P=0.462N       |     P=0.498N        P=0.103N        P=0.522        |
|COCHRAN-ARMITAGE       |     P=0.382N                                       |     P=0.379N                                       |
|FISHER EXACT           |                     P=0.421N        P=0.421N       |                     P=0.151N        P=0.420N       |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05028 TEST: 01                                                 PAGE  25
                            STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- HEXACHLOROETHANE
 
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      VEHICLE         .01G/KG         .02G/KG       |      VEHICLE         .08G/KG         .16G/KG       |
|                       |      MALE            LM              HM            |      FEMALE          LF              HF            |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    48/50 (96%)     49/50 (98%)     48/50 (96%)     |    50/50 (100%)    44/50 (88%)     43/50 (86%)     |
|ADJUSTED (b)           |    100.0%          100.0%          100.0%          |    100.0%           88.0%           89.6%          |
|TERMINAL (d)           |    31/31 (100%)    29/29 (100%)    26/26 (100%)    |    32/32 (100%)    21/27 (78%)     27/32 (84%)     |
|FIRST INCIDENCE (DAYS) |      406             370             467           |      506             396             450           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.139         P=0.339         P=0.160        |     P=0.201N        P=0.545N        P=0.196N       |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.021N*       P=0.009N**      P=0.022N*      |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.019N*       P=0.009N**      P=0.013N*      |
|COCHRAN-ARMITAGE       |     P=0.610                                        |     P=0.010N*                                      |
|FISHER EXACT           |                     P=0.500         P=0.691N       |                     P=0.013N*       P=0.006N**     |
|=================================================================================================================================|
 
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
 
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).

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