National Toxicology Program

National Toxicology Program
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TDMS Study 05028-01 Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Mason                                                     DATE: 09/04/94   
EXP: 05028                    HEXACHLOROETHANE                 TIME: 09:45:16   
TEST: 01              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 04604B   
CONT: N01CP9561904                                             CAS: 67-72-1     
PATHOLOGIST: A. RUSSFIELD                                                       
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
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REMOVAL DATE RANGE:                                                             


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INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Mason                                                     DATE: 09/04/94  
EXP: 05028                    HEXACHLOROETHANE                 TIME: 09:45:16  
TEST: 01              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 04604B  
CONT: N01CP9561904                                             CAS: 67-72-1    
PATHOLOGIST: A. RUSSFIELD                                                      

                                 HEXACHLOROETHANE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = VEHICLE                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 1    TERMINAL 31        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      353   406   530   568   585   589   630   637   638   646                 |
 |      646   654   666   667   687   714   720   726                             |
 |  CENSORED DEATHS                                                               |
 |      149                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = .01G/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 20     CENSORED DEATHS 1    TERMINAL 29        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      339   370   489   559   578   597   602   614   614   617                 |
 |      623   625   644   677   684   684   705   708   723   723                 |
 |  CENSORED DEATHS                                                               |
 |      665                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = .02G/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 23     CENSORED DEATHS 1    TERMINAL 26        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      359   467   472   483   534   550   558   577   586   587                 |
 |      613   630   632   636   639   649   653   682   692   700                 |
 |      703   709   724                                                           |
 |  CENSORED DEATHS                                                               |
 |      324                                                                       |
 |                                                                                |
 ==================================================================================

                                 HEXACHLOROETHANE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   733 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE    |   100.0 100.0 100.0  98.0  95.9  95.9  93.9  87.8  75.5  63.3      |
 |           |                                                                    |
 |           |                                                                    |
 |.01G/KG    |   100.0 100.0 100.0  98.0  96.0  96.0  94.0  86.0  74.0  59.6      |
 |           |                                                                    |
 |           |                                                                    |
 |.02G/KG    |   100.0 100.0 100.0  98.0  98.0  91.8  89.8  79.6  65.3  53.1      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                VEHICLE          .01G/KG          .02G/KG       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       63.3%            59.6%            53.1%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.290          P=0.806          P=0.332       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       614.6            608.8            601.5         |
 |NATURAL DEATHS (C)      |       (23.7)           (23.5)           (19.3)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       678.7            681.9            664.3         |
 |(STANDARD ERROR)        |       (15.9)           (12.7)           (14.5)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                 HEXACHLOROETHANE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 731 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = VEHICLE                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 0    TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      506   552   585   603   607   609   618   623   625   643                 |
 |      657   661   668   671   682   693   710   722                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = .08G/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 22     CENSORED DEATHS 1    TERMINAL 27        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      396   503   548   566   582   595   612   616   631   631                 |
 |      647   647   660   660   661   664   668   672   693   700                 |
 |      722   722                                                                 |
 |  CENSORED DEATHS                                                               |
 |      660                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = .16G/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 0    TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      406   450   462   465   575   581   581   588   626   628                 |
 |      630   630   643   645   692   706   715   727                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                 HEXACHLOROETHANE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 731 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   731 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE    |   100.0 100.0 100.0 100.0 100.0 100.0  98.0  92.0  76.0  64.0      |
 |           |                                                                    |
 |           |                                                                    |
 |.08G/KG    |   100.0 100.0 100.0 100.0  98.0  98.0  96.0  88.0  67.9  55.5      |
 |           |                                                                    |
 |           |                                                                    |
 |.16G/KG    |   100.0 100.0 100.0 100.0  98.0  92.0  92.0  84.0  72.0  64.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                VEHICLE          .08G/KG          .16G/KG       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       64.0%            55.5%            64.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.955          P=0.498          P=1.000       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       635.3            627.1            597.2         |
 |NATURAL DEATHS (C)      |       (13.0)           (16.1)           (22.5)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       696.5            683.9            682.8         |
 |(STANDARD ERROR)        |       ( 8.0)           (10.1)           (12.1)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                          HEXACHLOROETHANE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE          = 1
                                                        .01G/KG          = 2
                                                        .02G/KG          = 3

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                                     2 13
      |
      |                                                       2 132     1         3
      |                                                           2     1         33 2      1
   95 +
      |                                                                            332      1   2 1
      |                                                                                         2  2
      |                                                                             3        3    1 1
   90 +                                                                                      3 3   21 12
      |
      |                                                                                        33     1    1
      |                                                                                         3  3   2 2 11
P  85 +
E     |                                                                                            33       11
R     |                                                                                                  22
C     |                                                                                                      11
E  80 +                                                                                             3    3
N     |
T     |                                                                                                  322  11
      |                                                                                                    2 2
S  75 +                                                                                                    33  1  1
U     |                                                                                                      2     2
R     |                                                                                                            22
V     |                                                                                                     33    1  1
I  70 +                                                                                                      33      1  1
V     |
A     |                                                                                                       33    2  211
L     |                                                                                                                22
   65 +                                                                                                        3    3    11
      |                                                                                                             33  2 1 1
      |
      |                                                                                                              33
   60 +                                                                                                                   2 2
      |                                                                                                               33
      |                                                                                                                33
      |
   55 +                                                                                                                 3 3
      |
      |                                                                                                                   3 3
      |
   50 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 4 obs hidden.

                                                          HEXACHLOROETHANE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE          = 1
                                                        .08G/KG          = 2
                                                        .16G/KG          = 3

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                                              23               1
      |
      |                                                                23       3      21      1
      |                                                                         33     2       1    1
   95 +
      |                                                                          33            2 2  1   1
      |                                                                           3              2 32
      |
   90 +                                                                                             2 2
      |
P     |                                                                                               2 121
E     |                                                                                            33
R  85 +
C     |                                                                                             3    2112
E     |                                                                                                    1 1
N     |
T  80 +                                                                                                     2121
      |
S     |                                                                                                        1 1
U     |                                                                                                    3 32  11
R  75 +
V     |                                                                                                      33
I     |                                                                                                       3   1 13
V     |
A  70 +                                                                                                             11 3
L     |
      |                                                                                                          22  1 313
      |                                                                                                                 131
   65 +
      |                                                                                                           2  2    1 1
      |
      |                                                                                                              22
   60 +                                                                                                               2   2
      |
      |
      |
   55 +                                                                                                                   2 2
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 9 obs hidden.

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