National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3869

TDMS Study 05031-01 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                         MERCURIC CHLORIDE


NTP Experiment-Test: 05031-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/04/94
Route: GAVAGE                                                                                                     Time: 16:24:48




       Facility:  International Research and Development Corp.

       Chemical CAS #:  7487-94-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05031-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94    
Route: GAVAGE                                                                                                     Time: 16:24:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      5MG/KG       10MG/KG                                                
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Moribund                                           4           11            8                                                  
    Dead                                               5            4           10                                                  
    Gavage Death                                                                 1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                41           35           31                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)                                                
   Gallbladder                                        (38)         (41)         (35)                                                
   Intestine Large, Cecum                             (45)         (49)         (42)                                                
   Intestine Large, Colon                             (49)         (50)         (48)                                                
   Intestine Large, Rectum                            (44)         (46)         (49)                                                
   Intestine Small, Duodenum                          (45)         (47)         (43)                                                
   Intestine Small, Jejunum                           (48)         (48)         (41)                                                
   Liver                                              (50)         (50)         (50)                                                
      Hemangiosarcoma                                  1 (2%)       1 (2%)                                                          
      Hemangiosarcoma, Metastatic, Spleen                                        1 (2%)                                             
      Hepatocellular Carcinoma                         2 (4%)                                                                       
      Hepatocellular Carcinoma, Multiple                            1 (2%)                                                          
      Hepatocellular Adenoma                           1 (2%)                    2 (4%)                                             
      Squamous Cell Carcinoma, Metastatic, Stomach                               1 (2%)                                             
   Mesentery                                          (6)          (1)          (3)                                                 
   Pancreas                                           (50)         (50)         (47)                                                
   Salivary Glands                                    (49)         (48)         (50)                                                
   Stomach, Forestomach                               (48)         (50)         (48)                                                
      Squamous Cell Carcinoma                          1 (2%)                    1 (2%)                                             
      Squamous Cell Papilloma                                                    2 (4%)                                             
   Stomach, Glandular                                 (48)         (50)         (46)                                                
      Squamous Cell Carcinoma, Metastatic, Stomach                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (6)          (8)          (17)                                                
   Heart                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05031-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94    
Route: GAVAGE                                                                                                     Time: 16:24:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      5MG/KG       10MG/KG                                                
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (49)         (50)                                                
      Adenoma                                                                    1 (2%)                                             
   Adrenal Gland, Medulla                             (49)         (48)         (49)                                                
      Pheochromocytoma Benign                          1 (2%)       1 (2%)       1 (2%)                                             
   Islets, Pancreatic                                 (49)         (50)         (46)                                                
      Adenoma                                                       1 (2%)                                                          
   Pituitary Gland                                    (49)         (47)         (45)                                                
      Adenoma                                          2 (4%)       4 (9%)       2 (4%)                                             
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
   Thyroid Gland                                      (50)         (49)         (49)                                                
      Follicular Cell, Adenoma                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (3)          (3)                                                 
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                         1 (33%)      1 (33%)                                            
      Mediastinum, Hemangiosarcoma                                  1 (33%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (49)         (49)         (50)                                                
      Adenoma                                          4 (8%)       1 (2%)       1 (2%)                                             
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
      Teratoma                                                                   1 (2%)                                             
   Oviduct                                                                      (1)                                                 
   Uterus                                             (50)         (50)         (49)                                                
      Hemangioma                                                    1 (2%)                                                          
      Hemangiosarcoma                                               1 (2%)       1 (2%)                                             
      Leiomyosarcoma                                                1 (2%)                                                          
      Cervix, Granular Cell Tumor Benign                                         1 (2%)                                             
      Cervix, Endometrium, Polyp Stromal                                         1 (2%)                                             
      Endometrium, Polyp Stromal                       2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
   Lymph Node                                         (44)         (44)         (48)                                                
      Mesenteric, Squamous Cell Carcinoma,                                                                                          
          Metastatic, Stomach                                                    1 (2%)                                             
   Spleen                                             (49)         (50)         (48)                                                
      Hemangioma                                                                 1 (2%)                                             
      Hemangiosarcoma                                  1 (2%)       2 (4%)       1 (2%)                                             
                                                             Page   3                                                               
NTP Experiment-Test: 05031-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94    
Route: GAVAGE                                                                                                     Time: 16:24:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      5MG/KG       10MG/KG                                                
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Thymus                                             (41)         (39)         (43)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (3%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (47)         (46)         (46)                                                
      Adenocarcinoma                                                             1 (2%)                                             
   Skin                                               (50)         (50)         (50)                                                
      Fibrosarcoma                                                  4 (8%)                                                          
      Hemangiosarcoma                                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
   Skeletal Muscle                                    (3)                       (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Adenocarcinoma, Metastatic, Harderian Gland                                1 (2%)                                             
      Alveolar/Bronchiolar Adenoma                     2 (4%)       5 (10%)      2 (4%)                                             
      Alveolar/Bronchiolar Adenoma, Multiple                                     1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       2 (4%)       2 (4%)                                             
      Alveolar/Bronchiolar Carcinoma, Multiple                      1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Stomach                               1 (2%)                                             
   Nose                                               (50)         (50)         (50)                                                
   Trachea                                            (50)         (49)         (50)                                                
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05031-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94    
Route: GAVAGE                                                                                                     Time: 16:24:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      5MG/KG       10MG/KG                                                
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                 (1)          (1)                                                 
      Adenocarcinoma                                                             1 (100%)                                           
      Adenoma                                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (50)         (50)                                                
   Urinary Bladder                                    (48)         (48)         (47)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Lymphoma Malignant Histiocytic                                             1 (2%)                                             
      Lymphoma Malignant Lymphocytic                                1 (2%)                                                          
      Lymphoma Malignant Mixed                         9 (18%)      8 (16%)      4 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05031-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94    
Route: GAVAGE                                                                                                     Time: 16:24:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      5MG/KG       10MG/KG                                                
                                                   FEMALE       FEMALE       FEMALE                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            23          32          19                                                   
     Total Primary Neoplasms                           29          39          28                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 13          14          12                                                   
     Total Benign Neoplasms                            14          15          16                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              14          21          12                                                   
     Total Malignant Neoplasms                         15          24          12                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          2           4                                                   
     Total Metastatic Neoplasm                                      4           8                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05031-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94    
Route: GAVAGE                                                                                                     Time: 16:24:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      5MG/KG       10MG/KG                                                
                                                   MALE         MALE          MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Scheduled Sacrifice                                 10           10           10                                                  
  Early Deaths                                                                                                                      
    Dead                                               8           10            8                                                  
    Moribund                                           6            4           11                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                35           36           31                                                  
    Dead                                               1                                                                            
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (48)         (49)                                                
   Intestine Large, Rectum                            (47)         (47)         (49)                                                
      Adenocarcinoma                                                1 (2%)                                                          
   Intestine Small, Duodenum                          (46)         (43)         (45)                                                
      Polyp Adenomatous                                1 (2%)                                                                       
   Intestine Small, Ileum                             (44)         (43)         (45)                                                
   Intestine Small, Jejunum                           (48)         (43)         (45)                                                
   Liver                                              (50)         (50)         (50)                                                
      Hemangioma                                       1 (2%)       1 (2%)                                                          
      Hepatocellular Carcinoma                         2 (4%)       2 (4%)       6 (12%)                                            
      Hepatocellular Carcinoma, Multiple               3 (6%)       1 (2%)                                                          
      Hepatocellular Adenoma                           1 (2%)                    1 (2%)                                             
      Hepatocellular Adenoma, Multiple                 1 (2%)       1 (2%)                                                          
   Mesentery                                          (3)                       (2)                                                 
   Pancreas                                           (50)         (46)         (49)                                                
      Hemangioma                                                                 1 (2%)                                             
   Salivary Glands                                    (50)         (48)         (49)                                                
   Stomach, Forestomach                               (50)         (48)         (50)                                                
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Squamous Cell Papilloma                                                    1 (2%)                                             
   Stomach, Glandular                                 (49)         (47)         (49)                                                
   Tooth                                              (3)          (2)          (3)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (10)         (14)         (18)                                                
      Vena Cava, Fibrosarcoma, Metastatic, Skin                                  1 (6%)                                             
   Heart                                              (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                             Page   7                                                               
NTP Experiment-Test: 05031-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94    
Route: GAVAGE                                                                                                     Time: 16:24:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      5MG/KG       10MG/KG                                                
                                                   MALE         MALE          MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (49)                                                
      Adenoma                                          1 (2%)                                                                       
      Subcapsular, Adenoma                             1 (2%)                    1 (2%)                                             
   Adrenal Gland, Medulla                             (45)         (50)         (49)                                                
      Pheochromocytoma Benign                          1 (2%)       1 (2%)                                                          
   Pituitary Gland                                    (48)         (47)         (47)                                                
      Adenoma                                          1 (2%)                                                                       
      Pars Intermedia, Adenoma                         2 (4%)                    1 (2%)                                             
   Thyroid Gland                                      (49)         (47)         (49)                                                
      Follicular Cell, Adenoma                                      1 (2%)                                                          
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)          (1)                                                 
      Mediastinum, Fibrosarcoma, Metastatic, Skin                                1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Penis                                              (4)          (2)          (6)                                                 
   Prostate                                           (46)         (49)         (46)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
   Lymph Node                                         (44)         (48)         (43)                                                
   Spleen                                             (50)         (49)         (49)                                                
   Thymus                                             (26)         (34)         (27)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)                                                
      Fibroma                                                       1 (2%)                                                          
      Fibrosarcoma                                     2 (4%)       3 (6%)                                                          
      Fibrosarcoma, Metastatic                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05031-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94    
Route: GAVAGE                                                                                                     Time: 16:24:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      5MG/KG       10MG/KG                                                
                                                   MALE         MALE          MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (2)          (2)                                                              
      Fibrosarcoma                                                  1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     6 (12%)      5 (10%)      3 (6%)                                             
      Alveolar/Bronchiolar Adenoma, Multiple                        3 (6%)       1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   4 (8%)                    2 (4%)                                             
      Carcinoma, Metastatic, Uncertain Primary Site                 1 (2%)                                                          
      Fibrosarcoma, Metastatic, Skin                                             1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      2 (4%)       1 (2%)       1 (2%)                                             
   Nose                                               (50)         (50)         (50)                                                
   Trachea                                            (50)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)          (3)          (1)                                                 
      Adenoma                                                       3 (100%)     1 (100%)                                           
      Adenoma, Multiple                                1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)                                                
      Renal Tubule, Adenocarcinoma                                               1 (2%)                                             
      Renal Tubule, Adenoma                                                      2 (4%)                                             
   Urinary Bladder                                    (45)         (48)         (46)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Lymphoma Malignant Histiocytic                   1 (2%)                                                                       
      Lymphoma Malignant Mixed                         7 (14%)      2 (4%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   9                                                               
NTP Experiment-Test: 05031-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05  
Study Type: CHRONIC                                         MERCURIC CHLORIDE                                     Date: 09/04/94    
Route: GAVAGE                                                                                                     Time: 16:24:48    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      5MG/KG       10MG/KG                                                
                                                   MALE         MALE          MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            28          20          17                                                   
     Total Primary Neoplasms                           37          27          24                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 13          15          10                                                   
     Total Benign Neoplasms                            17          16          12                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              20          10          11                                                   
     Total Malignant Neoplasms                         20          11          12                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           2           2                                                   
     Total Metastatic Neoplasm                          2           2           5                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  10                                                               
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