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TDMS Study 05033-01 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Mason                                                     QUERCETIN                                       DATE: 09/04/94       
EXPERIMENT: 05033 TEST: 01                                                                                     TIME: 20:45:56       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01CP9561903          ROUTE: DOSED FEED                                                                  NTP C#: 60106        
PATHOLOGIST: R. FLEISCHMAN                   S. EUSTIS                                                         CAS: 117-39-5        
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08    
LAB: Mason                                                     QUERCETIN                                       DATE: 09/04/94      
EXPERIMENT: 05033 TEST: 01                                                                                     TIME: 20:45:56      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: N01CP9561903          ROUTE: DOSED FEED                                                                  NTP C#: 60106       
PATHOLOGIST: R. FLEISCHMAN                   S. EUSTIS                                                         CAS: 117-39-5       
 
 
 
 
 
                                                    RATS(FISCHER344)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
 
 
                                                    ----------------
 
                                                    Adrenal Gland
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Epididymis
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Mason                                                     QUERCETIN                                       DATE: 09/04/94       
EXPERIMENT: 05033 TEST: 01                                                                                     TIME: 20:45:56       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01CP9561903          ROUTE: DOSED FEED                                                                  NTP C#: 60106        
PATHOLOGIST: R. FLEISCHMAN                   S. EUSTIS                                                         CAS: 117-39-5        
 
 
 
 
 
                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                           IN THE ANALYSIS OF THE STUDY OF QUERCETIN
 
              ====================================================================================================
 
                                                           MALE RATS
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
 
                             Adrenal Medulla               Pheochromocytoma Benign
                                                           Pheochromocytoma: Benign, Complex, Malignant, NOS
                             Clitoral/Preputial Gland      Carcinoma
                             Islets, Pancreatic            Adenoma
                                                           Carcinoma or Adenoma
                             Kidney: Renal Tubule          Adenoma
                                                           Carcinoma or Adenoma
                             Thyroid Gland: C-Cell         Carcinoma or Adenoma
                             All Organs                    Malignant Tumors
                                                           Malignant and Benign Tumors
 
              ====================================================================================================
 
                                                           FEMALE RATS
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
 
                             Adrenal Medulla               Pheochromocytoma Benign
                                                           Pheochromocytoma: Benign, Complex, Malignant, NOS
                             Clitoral/Preputial Gland      Adenoma
                             Islets, Pancreatic            Adenoma
                                                           Carcinoma or Adenoma
                             Lung                          Alveolar/Bronchiolar Adenoma
                                                           Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
                             Mammary Gland                 Fibroadenoma
                                                           Fibroma, Fibroadenoma, Carcinoma, or Adenoma
                             Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip)
                                                           Squamous Cell Carcinoma
                                                           Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma
                             Pituitary Gland: Pars Distalis or Unspecified Site
                                                           Adenoma
                             Tongue                        Squamous Cell Carcinoma
                                                           Squamous Cell Carcinoma or Papilloma Squamous
                             Uterus                        Polyp Stromal
                                                           Sarcoma Stromal or Polyp Stromal
                             All Organs                    Benign Tumors
                                                           Malignant and Benign Tumors
 
              ====================================================================================================
         DATE: 09/04/94                     EXPERIMENT: 05033 TEST: 01                                                 PAGE   1
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.1% LM      1.0% MM      4.0% HM   |   CONTROL      0.1% LF      1.0% MF      4.0% HF   |
|                       |   UM                                               |   UF                                               |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 12/50 (24%)   4/18 (22%)  10/21 (48%)  11/49 (22%) |  3/49 (6%)    0/13 (0%)    3/12 (25%)   1/50 (2%)  |
|ADJUSTED (b)           |  37.6%        52.9%        74.9%        36.0%      |   7.8%         0.0%       100.0%         3.6%      |
|TERMINAL (d)           |  7/26 (27%)   2/4 (50%)    5/7 (71%)    6/23 (26%) |  1/30 (3%)    0/0          3/3 (100%)   1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |   575          620          555          662       |   625          ---          723 (T)      723 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.545N     P=0.435N     P=0.142      P=0.568N   |  P=0.239N     P=0.267N     P=0.101      P=0.340N   |
|INCIDENTAL TUMOR       |  P=0.247N     P=0.327      P=0.016 *    P=0.459N   |  P=0.207N     P=0.423N     P=0.022 *    P=0.313N   |
|LOGISTIC REGRESSION    |  P=0.256N     P=0.342      P=0.009 **   P=0.503N   |  P=0.212N     P=0.367N     P=0.018 *    P=0.291N   |
|COCHRAN-ARMITAGE       |  P=0.385N                                          |  P=0.234N                                          |
|FISHER EXACT           |               P=0.578N     P=0.048 *    P=0.522N   |               P=0.487N     P=0.084      P=0.301N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Malignant                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/18 (0%)    1/21 (5%)    2/49 (4%)  |  1/49 (2%)    1/13 (8%)    0/12 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   3.3%         0.0%        14.3%         6.3%      |   3.3%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/26 (0%)    0/4 (0%)     1/7 (14%)    0/23 (0%)  |  1/30 (3%)    0/0          0/3 (0%)     0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   717          ---          724 (T)      662       |   723 (T)      497          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.268      P=0.493N     P=0.602      P=0.492    |  P=0.273N     P=0.504      P=0.923N     P=0.514N   |
|INCIDENTAL TUMOR       |  P=0.555      P=0.860N     P=0.386      P=0.615    |  P=0.266N       (e)        P=0.923N     P=0.514N   |
|LOGISTIC REGRESSION    |  P=0.432      P=0.824N     P=0.429      P=0.497    |  P=0.229N     P=0.853N     P=0.923N     P=0.514N   |
|COCHRAN-ARMITAGE       |  P=0.374                                           |  P=0.244N                                          |
|FISHER EXACT           |               P=0.735N     P=0.507      P=0.492    |               P=0.378      P=0.803N     P=0.495N   |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05033 TEST: 01                                                 PAGE   2
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.1% LM      1.0% MM      4.0% HM   |   CONTROL      0.1% LF      1.0% MF      4.0% HF   |
|                       |   UM                                               |   UF                                               |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 13/50 (26%)   4/18 (22%)  11/21 (52%)  12/49 (24%) |  3/49 (6%)    1/13 (8%)    3/12 (25%)   1/50 (2%)  |
|ADJUSTED (b)           |  39.7%        52.9%        87.4%        38.5%      |   7.8%         0.0%       100.0%         3.6%      |
|TERMINAL (d)           |  7/26 (27%)   2/4 (50%)    6/7 (86%)    6/23 (26%) |  1/30 (3%)    0/0          3/3 (100%)   1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |   575          620          555          662       |   625          497          723 (T)      723 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.539      P=0.322N     P=0.115      P=0.574N   |  P=0.185N     P=0.526N     P=0.101      P=0.340N   |
|INCIDENTAL TUMOR       |  P=0.223N     P=0.366      P=0.006 **   P=0.430N   |  P=0.157N     P=0.423N     P=0.022 *    P=0.313N   |
|LOGISTIC REGRESSION    |  P=0.247N     P=0.389      P=0.003 **   P=0.501N   |  P=0.158N     P=0.339N     P=0.018 *    P=0.291N   |
|COCHRAN-ARMITAGE       |  P=0.398N                                          |  P=0.160N                                          |
|FISHER EXACT           |               P=0.510N     P=0.032 *    P=0.523N   |               P=0.620      P=0.084      P=0.301N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/13 (15%)   5/22 (23%)   3/19 (16%)   1/15 (7%)  |  4/14 (29%)   4/20 (20%)   3/14 (21%)   4/12 (33%) |
|ADJUSTED (b)           |   4.8%        25.3%        60.0%        25.0%      |  80.0%        39.7%        35.1%       100.0%      |
|TERMINAL (d)           |  0/1 (0%)     1/6 (17%)    3/5 (60%)    1/4 (25%)  |  4/5 (80%)    3/8 (38%)    2/6 (33%)    2/2 (100%) |
|FIRST INCIDENCE (DAYS) |   562          618          724 (T)      724 (T)   |   723 (T)      721          707          632       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.136N     P=0.317      P=0.502N     P=0.344N   |  P=0.108      P=0.387N     P=0.379N     P=0.163    |
|INCIDENTAL TUMOR       |  P=0.159N     P=0.532      P=0.474N     P=0.350N   |  P=0.046 *    P=0.477N     P=0.431N     P=0.108    |
|LOGISTIC REGRESSION    |  P=0.158N     P=0.599      P=0.531N     P=0.402N   |  P=0.040 *    P=0.257N     P=0.373N     P=0.084    |
|COCHRAN-ARMITAGE       |  P=0.200N                                          |  P=0.354                                           |
|FISHER EXACT           |               P=0.475      P=0.683      P=0.444N   |               P=0.428N     P=0.500N     P=0.563    |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05033 TEST: 01                                                 PAGE   3
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.1% LM      1.0% MM      4.0% HM   |   CONTROL      0.1% LF      1.0% MF      4.0% HF   |
|                       |   UM                                               |   UF                                               |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/13 (8%)    0/22 (0%)    1/19 (5%)    3/15 (20%) |  1/14 (7%)    1/20 (5%)    2/14 (14%)   0/12 (0%)  |
|ADJUSTED (b)           |   2.3%         0.0%        20.0%        29.0%      |   2.9%        12.5%        18.8%         0.0%      |
|TERMINAL (d)           |  0/1 (0%)     0/6 (0%)     1/5 (20%)    1/4 (25%)  |  0/5 (0%)     1/8 (13%)    1/6 (17%)    0/2 (0%)   |
|FIRST INCIDENCE (DAYS) |   620          ---          724 (T)      626       |   700          723 (T)      697          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.085      P=0.514N     P=0.613N     P=0.426    |  P=0.460N     P=0.728N     P=0.543      P=0.524N   |
|INCIDENTAL TUMOR       |  P=0.044 *    P=0.477N     P=0.571N     P=0.340    |  P=0.576N     P=0.713      P=0.421      P=0.718N   |
|LOGISTIC REGRESSION    |  P=0.049 *    P=0.408N     P=0.598N     P=0.457    |  P=0.567N     P=0.714N     P=0.494      P=0.651N   |
|COCHRAN-ARMITAGE       |  P=0.045 *                                         |  P=0.410N                                          |
|FISHER EXACT           |               P=0.371N     P=0.655N     P=0.356    |               P=0.661N     P=0.500      P=0.538N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/13 (23%)   5/22 (23%)   4/19 (21%)   4/15 (27%) |  5/14 (36%)   5/20 (25%)   5/14 (36%)   4/12 (33%) |
|ADJUSTED (b)           |   7.0%        25.3%        80.0%        52.6%      |  80.6%        51.7%        52.6%       100.0%      |
|TERMINAL (d)           |  0/1 (0%)     1/6 (17%)    4/5 (80%)    2/4 (50%)  |  4/5 (80%)    4/8 (50%)    3/6 (50%)    2/2 (100%) |
|FIRST INCIDENCE (DAYS) |   562          618          724 (T)      626       |   700          721          697          632       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.560N     P=0.463      P=0.374N     P=0.614N   |  P=0.235      P=0.370N     P=0.533N     P=0.358    |
|INCIDENTAL TUMOR       |  P=0.537      P=0.629N     P=0.323N     P=0.658    |  P=0.073      P=0.530N     P=0.681N     P=0.188    |
|LOGISTIC REGRESSION    |  P=0.545      P=0.549N     P=0.396N     P=0.666N   |  P=0.075      P=0.333N     P=0.639N     P=0.151    |
|COCHRAN-ARMITAGE       |  P=0.487                                           |  P=0.519                                           |
|FISHER EXACT           |               P=0.645N     P=0.611N     P=0.588    |               P=0.382N     P=0.653N     P=0.613N   |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05033 TEST: 01                                                 PAGE   4
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.1% LM      1.0% MM      4.0% HM   |   CONTROL      0.1% LF      1.0% MF      4.0% HF   |
|                       |   UM                                               |   UF                                               |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/47 (0%)    2/15 (13%)   0/13 (0%)    3/41 (7%)  |  2/44 (5%)    3/15 (20%)   1/8 (13%)    0/49 (0%)  |
|ADJUSTED (b)           |   0.0%        51.5%         0.0%        11.9%      |   6.3%        75.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/25 (0%)    1/2 (50%)    0/0          1/18 (6%)  |  1/27 (4%)    3/4 (75%)    0/0          0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          704          ---          694       |   687          723 (T)      666          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.164      P=0.053        (e)        P=0.101    |  P=0.051N     P=0.029 *    P=0.746N     P=0.245N   |
|INCIDENTAL TUMOR       |  P=0.425      P<0.001 **     (e)        P=0.141    |  P=0.030N*    P<0.001 **   P=0.227      P=0.224N   |
|LOGISTIC REGRESSION    |  P=0.325      P<0.001 **     (e)        P=0.100    |  P=0.035N*    P=0.003 **   P=0.255      P=0.225N   |
|COCHRAN-ARMITAGE       |  P=0.228                                           |  P=0.044N*                                         |
|FISHER EXACT           |               P=0.056        (e)        P=0.097    |               P=0.099      P=0.401      P=0.221N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/47 (0%)    2/15 (13%)   1/13 (8%)    3/41 (7%)  |  2/44 (5%)    3/15 (20%)   1/8 (13%)    0/49 (0%)  |
|ADJUSTED (b)           |   0.0%        51.5%         0.0%        11.9%      |   6.3%        75.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/25 (0%)    1/2 (50%)    0/0          1/18 (6%)  |  1/27 (4%)    3/4 (75%)    0/0          0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          704          699          694       |   687          723 (T)      666          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.197      P=0.053      P=0.487      P=0.101    |  P=0.051N     P=0.029 *    P=0.746N     P=0.245N   |
|INCIDENTAL TUMOR       |  P=0.537      P<0.001 **   P=0.056      P=0.141    |  P=0.030N*    P<0.001 **   P=0.227      P=0.224N   |
|LOGISTIC REGRESSION    |  P=0.398      P<0.001 **   P=0.053      P=0.100    |  P=0.035N*    P=0.003 **   P=0.255      P=0.225N   |
|COCHRAN-ARMITAGE       |  P=0.287                                           |  P=0.044N*                                         |
|FISHER EXACT           |               P=0.056      P=0.217      P=0.097    |               P=0.099      P=0.401      P=0.221N   |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05033 TEST: 01                                                 PAGE   5
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.1% LM      1.0% MM      4.0% HM   |   CONTROL      0.1% LF      1.0% MF      4.0% HF   |
|                       |   UM                                               |   UF                                               |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    3/50 (6%)  |  0/49 (0%)    0/49 (0%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%        11.1%      |   0.0%         0.0%         2.9%         0.0%      |
|TERMINAL (d)           |  0/26 (0%)    0/28 (0%)    0/25 (0%)    2/23 (9%)  |  0/30 (0%)    0/28 (0%)    1/35 (3%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          676       |   ---          ---          723 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.007 **     (e)          (e)        P=0.114    |  P=0.789N       (e)        P=0.531        (e)      |
|INCIDENTAL TUMOR       |  P=0.011 *      (e)          (e)        P=0.129    |  P=0.789N       (e)        P=0.531        (e)      |
|LOGISTIC REGRESSION    |  P=0.009 **     (e)          (e)        P=0.122    |  P=0.789N       (e)        P=0.531        (e)      |
|COCHRAN-ARMITAGE       |  P=0.008 **                                        |  P=0.773N                                          |
|FISHER EXACT           |                 (e)          (e)        P=0.121    |                 (e)        P=0.505        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    4/50 (8%)  |  0/49 (0%)    0/49 (0%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%        15.3%      |   0.0%         0.0%         2.9%         0.0%      |
|TERMINAL (d)           |  0/26 (0%)    0/28 (0%)    0/25 (0%)    3/23 (13%) |  0/30 (0%)    0/28 (0%)    1/35 (3%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          676       |   ---          ---          723 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.001 **     (e)          (e)        P=0.056    |  P=0.789N       (e)        P=0.531        (e)      |
|INCIDENTAL TUMOR       |  P=0.002 **     (e)          (e)        P=0.063    |  P=0.789N       (e)        P=0.531        (e)      |
|LOGISTIC REGRESSION    |  P=0.002 **     (e)          (e)        P=0.064    |  P=0.789N       (e)        P=0.531        (e)      |
|COCHRAN-ARMITAGE       |  P=0.002 **                                        |  P=0.773N                                          |
|FISHER EXACT           |                 (e)          (e)        P=0.059    |                 (e)        P=0.505        (e)      |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05033 TEST: 01                                                 PAGE   6
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.1% LM      1.0% MM      4.0% HM   |   CONTROL      0.1% LF      1.0% MF      4.0% HF   |
|                       |   UM                                               |   UF                                               |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    3/50 (6%)    4/50 (8%)    0/50 (0%)  |  0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |  11.5%        10.7%        16.0%         0.0%      |   0.0%         3.6%         0.0%         3.6%      |
|TERMINAL (d)           |  3/26 (12%)   3/28 (11%)   4/25 (16%)   0/23 (0%)  |  0/30 (0%)    1/28 (4%)    0/35 (0%)    1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |   724 (T)      724 (T)      724 (T)      ---       |   ---          723 (T)      ---          723 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.105N     P=0.631N     P=0.478      P=0.142N   |  P=0.478      P=0.486        (e)        P=0.486    |
|INCIDENTAL TUMOR       |  P=0.105N     P=0.631N     P=0.478      P=0.142N   |  P=0.478      P=0.486        (e)        P=0.486    |
|LOGISTIC REGRESSION    |  P=0.105N     P=0.631N     P=0.478      P=0.142N   |  P=0.478      P=0.486        (e)        P=0.486    |
|COCHRAN-ARMITAGE       |  P=0.082N                                          |  P=0.491                                           |
|FISHER EXACT           |               P=0.661N     P=0.500      P=0.121N   |               P=0.500        (e)        P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    4/50 (8%)    4/50 (8%)    1/50 (2%)  |  0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |  11.5%        14.3%        16.0%         4.3%      |   0.0%         3.6%         0.0%         3.6%      |
|TERMINAL (d)           |  3/26 (12%)   4/28 (14%)   4/25 (16%)   1/23 (4%)  |  0/30 (0%)    1/28 (4%)    0/35 (0%)    1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |   724 (T)      724 (T)      724 (T)      724 (T)   |   ---          723 (T)      ---          723 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.208N     P=0.541      P=0.478      P=0.348N   |  P=0.478      P=0.486        (e)        P=0.486    |
|INCIDENTAL TUMOR       |  P=0.208N     P=0.541      P=0.478      P=0.348N   |  P=0.478      P=0.486        (e)        P=0.486    |
|LOGISTIC REGRESSION    |  P=0.208N     P=0.541      P=0.478      P=0.348N   |  P=0.478      P=0.486        (e)        P=0.486    |
|COCHRAN-ARMITAGE       |  P=0.161N                                          |  P=0.491                                           |
|FISHER EXACT           |               P=0.500      P=0.500      P=0.309N   |               P=0.500        (e)        P=0.500    |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05033 TEST: 01                                                 PAGE   7
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.1% LM      1.0% MM      4.0% HM   |   CONTROL      0.1% LF      1.0% MF      4.0% HF   |
|                       |   UM                                               |   UF                                               |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    4/50 (8%)    4/50 (8%)    1/50 (2%)  |  0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |  11.5%        14.3%        16.0%         4.3%      |   0.0%         3.6%         0.0%         3.6%      |
|TERMINAL (d)           |  3/26 (12%)   4/28 (14%)   4/25 (16%)   1/23 (4%)  |  0/30 (0%)    1/28 (4%)    0/35 (0%)    1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |   724 (T)      724 (T)      724 (T)      724 (T)   |   ---          723 (T)      ---          723 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.208N     P=0.541      P=0.478      P=0.348N   |  P=0.478      P=0.486        (e)        P=0.486    |
|INCIDENTAL TUMOR       |  P=0.208N     P=0.541      P=0.478      P=0.348N   |  P=0.478      P=0.486        (e)        P=0.486    |
|LOGISTIC REGRESSION    |  P=0.208N     P=0.541      P=0.478      P=0.348N   |  P=0.478      P=0.486        (e)        P=0.486    |
|COCHRAN-ARMITAGE       |  P=0.161N                                          |  P=0.491                                           |
|FISHER EXACT           |               P=0.500      P=0.500      P=0.309N   |               P=0.500        (e)        P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    0/28 (0%)    1/31 (3%)    1/50 (2%)  |  5/50 (10%)   0/20 (0%)    1/20 (5%)    0/50 (0%)  |
|ADJUSTED (b)           |   7.7%         0.0%         2.0%         4.3%      |  14.3%         0.0%        12.5%         0.0%      |
|TERMINAL (d)           |  2/26 (8%)    0/9 (0%)     0/9 (0%)     1/23 (4%)  |  3/30 (10%)   0/2 (0%)     1/8 (13%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   724 (T)      ---          427          724 (T)   |   641          ---          723 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.579N     P=0.491N     P=0.731N     P=0.543N   |  P=0.052N     P=0.219N     P=0.371N     P=0.044N*  |
|INCIDENTAL TUMOR       |  P=0.634N     P=0.491N     P=0.731N     P=0.543N   |  P=0.049N*    P=0.243N     P=0.500N     P=0.037N*  |
|LOGISTIC REGRESSION    |  P=0.578N     P=0.491N     P=0.643N     P=0.543N   |  P=0.050N*    P=0.250N     P=0.501N     P=0.036N*  |
|COCHRAN-ARMITAGE       |  P=0.571N                                          |  P=0.055N                                          |
|FISHER EXACT           |               P=0.408N     P=0.675N     P=0.500N   |               P=0.175N     P=0.444N     P=0.028N*  |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05033 TEST: 01                                                 PAGE   8
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.1% LM      1.0% MM      4.0% HM   |   CONTROL      0.1% LF      1.0% MF      4.0% HF   |
|                       |   UM                                               |   UF                                               |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    0/28 (0%)    1/31 (3%)    1/50 (2%)  |  5/50 (10%)   1/20 (5%)    1/20 (5%)    0/50 (0%)  |
|ADJUSTED (b)           |   7.7%         0.0%         2.0%         4.3%      |  14.3%         2.2%        12.5%         0.0%      |
|TERMINAL (d)           |  2/26 (8%)    0/9 (0%)     0/9 (0%)     1/23 (4%)  |  3/30 (10%)   0/2 (0%)     1/8 (13%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   724 (T)      ---          427          724 (T)   |   641          548          723 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.579N     P=0.491N     P=0.731N     P=0.543N   |  P=0.038N*    P=0.452N     P=0.371N     P=0.044N*  |
|INCIDENTAL TUMOR       |  P=0.634N     P=0.491N     P=0.731N     P=0.543N   |  P=0.033N*    P=0.462N     P=0.500N     P=0.037N*  |
|LOGISTIC REGRESSION    |  P=0.578N     P=0.491N     P=0.643N     P=0.543N   |  P=0.035N*    P=0.394N     P=0.501N     P=0.036N*  |
|COCHRAN-ARMITAGE       |  P=0.571N                                          |  P=0.036N*                                         |
|FISHER EXACT           |               P=0.408N     P=0.675N     P=0.500N   |               P=0.444N     P=0.444N     P=0.028N*  |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  1/50 (2%)    0/50 (0%)    3/50 (6%)    2/50 (4%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   2.5%         0.0%         7.9%         6.0%      |
|TERMINAL (d)           |  0/26 (0%)    0/28 (0%)    0/25 (0%)    0/23 (0%)  |  0/30 (0%)    0/28 (0%)    2/35 (6%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   672          ---          660          686       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.299      P=0.521N     P=0.340      P=0.468    |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.291      P=0.536N     P=0.261      P=0.434    |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.307      P=0.488N     P=0.304      P=0.492    |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.318                                           |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.500N     P=0.309      P=0.500    |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05033 TEST: 01                                                 PAGE   9
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.1% LM      1.0% MM      4.0% HM   |   CONTROL      0.1% LF      1.0% MF      4.0% HF   |
|                       |   UM                                               |   UF                                               |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/50 (10%)   1/50 (2%)    5/50 (10%)   3/50 (6%)  | 29/50 (58%)  27/50 (54%)  16/50 (32%)   9/50 (18%) |
|ADJUSTED (b)           |  16.3%         3.6%        17.3%        13.0%      |  66.4%        72.3%        38.4%        30.1%      |
|TERMINAL (d)           |  3/26 (12%)   1/28 (4%)    3/25 (12%)   3/23 (13%) | 16/30 (53%)  18/28 (64%)  10/35 (29%)   8/28 (29%) |
|FIRST INCIDENCE (DAYS) |   590          724 (T)      673          724 (T)   |   597          597          605          549       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.590      P=0.094N     P=0.612      P=0.401N   |  P<0.001N**   P=0.531      P=0.008N**   P<0.001N** |
|INCIDENTAL TUMOR       |  P=0.567N     P=0.100N     P=0.629      P=0.413N   |  P<0.001N**   P=0.574N     P=0.021N*    P<0.001N** |
|LOGISTIC REGRESSION    |  P=0.546N     P=0.100N     P=0.624      P=0.350N   |  P<0.001N**   P=0.534N     P=0.008N**   P<0.001N** |
|COCHRAN-ARMITAGE       |  P=0.551N                                          |  P<0.001N**                                        |
|FISHER EXACT           |               P=0.102N     P=0.630N     P=0.357N   |               P=0.420N     P=0.008N**   P<0.001N** |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/50 (10%)   1/50 (2%)    5/50 (10%)   3/50 (6%)  | 30/50 (60%)  27/50 (54%)  17/50 (34%)  11/50 (22%) |
|ADJUSTED (b)           |  16.3%         3.6%        17.3%        13.0%      |  67.2%        72.3%        40.8%        34.3%      |
|TERMINAL (d)           |  3/26 (12%)   1/28 (4%)    3/25 (12%)   3/23 (13%) | 16/30 (53%)  18/28 (64%)  11/35 (31%)   8/28 (29%) |
|FIRST INCIDENCE (DAYS) |   590          724 (T)      673          724 (T)   |   597          597          605          549       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.590      P=0.094N     P=0.612      P=0.401N   |  P<0.001N**   P=0.538N     P=0.008N**   P=0.002N** |
|INCIDENTAL TUMOR       |  P=0.567N     P=0.100N     P=0.629      P=0.413N   |  P<0.001N**   P=0.500N     P=0.022N*    P<0.001N** |
|LOGISTIC REGRESSION    |  P=0.546N     P=0.100N     P=0.624      P=0.350N   |  P<0.001N**   P=0.448N     P=0.050N*    P<0.001N** |
|COCHRAN-ARMITAGE       |  P=0.551N                                          |  P<0.001N**                                        |
|FISHER EXACT           |               P=0.102N     P=0.630N     P=0.357N   |               P=0.343N     P=0.008N**   P<0.001N** |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05033 TEST: 01                                                 PAGE  10
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.1% LM      1.0% MM      4.0% HM   |   CONTROL      0.1% LF      1.0% MF      4.0% HF   |
|                       |   UM                                               |   UF                                               |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip)                                                                           |
|     Squamous Cell Carcinoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   0.0%         0.0%         0.0%         4.7%      |
|TERMINAL (d)           |  0/26 (0%)    0/28 (0%)    0/25 (0%)    0/23 (0%)  |  0/30 (0%)    0/28 (0%)    0/35 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   ---          ---          ---          492       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.039 *      (e)          (e)        P=0.227    |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.035 *      (e)          (e)        P=0.290    |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.067        (e)          (e)        P=0.327    |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.042 *                                         |
|FISHER EXACT           |                 (e)          (e)          (e)      |                 (e)          (e)        P=0.247    |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip)                                                                           |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         2.6%      |   0.0%         0.0%         0.0%         4.7%      |
|TERMINAL (d)           |  0/26 (0%)    0/28 (0%)    0/25 (0%)    0/23 (0%)  |  0/30 (0%)    0/28 (0%)    0/35 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          674       |   ---          ---          ---          492       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.241        (e)          (e)        P=0.522    |  P=0.039 *      (e)          (e)        P=0.227    |
|INCIDENTAL TUMOR       |  P=0.312        (e)          (e)        P=0.576    |  P=0.035 *      (e)          (e)        P=0.290    |
|LOGISTIC REGRESSION    |  P=0.225        (e)          (e)        P=0.500    |  P=0.067        (e)          (e)        P=0.327    |
|COCHRAN-ARMITAGE       |  P=0.224                                           |  P=0.042 *                                         |
|FISHER EXACT           |                 (e)          (e)        P=0.500    |                 (e)          (e)        P=0.247    |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05033 TEST: 01                                                 PAGE  11
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.1% LM      1.0% MM      4.0% HM   |   CONTROL      0.1% LF      1.0% MF      4.0% HF   |
|                       |   UM                                               |   UF                                               |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    2/50 (4%)    2/50 (4%)    0/47 (0%)  |  0/50 (0%)    0/49 (0%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |   0.0%         7.1%         6.5%         0.0%      |   0.0%         0.0%         0.0%         3.6%      |
|TERMINAL (d)           |  0/26 (0%)    2/28 (7%)    1/25 (4%)    0/23 (0%)  |  0/30 (0%)    0/28 (0%)    0/35 (0%)    1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |   ---          724 (T)      673          ---       |   ---          ---          ---          723 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.355N     P=0.254      P=0.244        (e)      |  P=0.211        (e)          (e)        P=0.486    |
|INCIDENTAL TUMOR       |  P=0.330N     P=0.254      P=0.235        (e)      |  P=0.211        (e)          (e)        P=0.486    |
|LOGISTIC REGRESSION    |  P=0.335N     P=0.254      P=0.235        (e)      |  P=0.211        (e)          (e)        P=0.486    |
|COCHRAN-ARMITAGE       |  P=0.348N                                          |  P=0.226                                           |
|FISHER EXACT           |               P=0.247      P=0.247        (e)      |                 (e)          (e)        P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 14/46 (30%)  17/49 (35%)  19/50 (38%)  12/48 (25%) | 37/50 (74%)  31/49 (63%)  35/50 (70%)  27/49 (55%) |
|ADJUSTED (b)           |  42.9%        45.4%        54.0%        34.5%      |  80.3%        74.7%        77.5%        68.5%      |
|TERMINAL (d)           |  8/25 (32%)   9/27 (33%)  10/25 (40%)   3/23 (13%) | 21/30 (70%)  18/28 (64%)  25/35 (71%)  16/28 (57%) |
|FIRST INCIDENCE (DAYS) |   519          546          592          422       |   597          497          441          549       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.278N     P=0.401      P=0.219      P=0.444N   |  P=0.166N     P=0.382N     P=0.218N     P=0.157N   |
|INCIDENTAL TUMOR       |  P=0.165N     P=0.418      P=0.245      P=0.308N   |  P=0.074N     P=0.232N     P=0.564N     P=0.072N   |
|LOGISTIC REGRESSION    |  P=0.191N     P=0.413      P=0.245      P=0.360N   |  P=0.073N     P=0.197N     P=0.441N     P=0.062N   |
|COCHRAN-ARMITAGE       |  P=0.192N                                          |  P=0.056N                                          |
|FISHER EXACT           |               P=0.412      P=0.287      P=0.360N   |               P=0.175N     P=0.412N     P=0.039N*  |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05033 TEST: 01                                                 PAGE  12
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.1% LM      1.0% MM      4.0% HM   |   CONTROL      0.1% LF      1.0% MF      4.0% HF   |
|                       |   UM                                               |   UF                                               |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 14/46 (30%)  17/49 (35%)  19/50 (38%)  12/48 (25%) | 37/50 (74%)  32/49 (65%)  35/50 (70%)  28/49 (57%) |
|ADJUSTED (b)           |  42.9%        45.4%        54.0%        34.5%      |  80.3%        75.3%        77.5%        71.2%      |
|TERMINAL (d)           |  8/25 (32%)   9/27 (33%)  10/25 (40%)   3/23 (13%) | 21/30 (70%)  18/28 (64%)  25/35 (71%)  17/28 (61%) |
|FIRST INCIDENCE (DAYS) |   519          546          592          422       |   597          497          441          549       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.278N     P=0.401      P=0.219      P=0.444N   |  P=0.198N     P=0.447N     P=0.218N     P=0.199N   |
|INCIDENTAL TUMOR       |  P=0.165N     P=0.418      P=0.245      P=0.308N   |  P=0.094N     P=0.296N     P=0.564N     P=0.106N   |
|LOGISTIC REGRESSION    |  P=0.191N     P=0.413      P=0.245      P=0.360N   |  P=0.093N     P=0.253N     P=0.441N     P=0.094N   |
|COCHRAN-ARMITAGE       |  P=0.192N                                          |  P=0.073N                                          |
|FISHER EXACT           |               P=0.412      P=0.287      P=0.360N   |               P=0.235N     P=0.412N     P=0.060N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    0/50 (0%)    3/50 (6%)    1/50 (2%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   7.7%         0.0%        12.0%         2.6%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  2/26 (8%)    0/28 (0%)    3/25 (12%)   0/23 (0%)  |  0/30 (0%)    0/28 (0%)    0/35 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   724 (T)      ---          724 (T)      676       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.632N     P=0.221N     P=0.482      P=0.516N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.601N     P=0.221N     P=0.482      P=0.485N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.589N     P=0.221N     P=0.482      P=0.495N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.586N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.247N     P=0.500      P=0.500N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05033 TEST: 01                                                 PAGE  13
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.1% LM      1.0% MM      4.0% HM   |   CONTROL      0.1% LF      1.0% MF      4.0% HF   |
|                       |   UM                                               |   UF                                               |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma,                                                                |
|     Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    0/50 (0%)    4/50 (8%)    1/50 (2%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |  11.5%         0.0%        15.3%         2.6%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  3/26 (12%)   0/28 (0%)    3/25 (12%)   0/23 (0%)  |  0/30 (0%)    0/28 (0%)    0/35 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   724 (T)      ---          704          676       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.493N     P=0.107N     P=0.471      P=0.329N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.428N     P=0.107N     P=0.481      P=0.304N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.440N     P=0.107N     P=0.454      P=0.299N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.438N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.121N     P=0.500      P=0.309N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    1/50 (2%)    1/50 (2%)    3/50 (6%)  |  2/50 (4%)    3/50 (6%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |   7.1%         3.0%         2.1%         8.8%      |   6.3%        10.2%         2.1%         0.0%      |
|TERMINAL (d)           |  1/26 (4%)    0/28 (0%)    0/25 (0%)    1/23 (4%)  |  1/30 (3%)    2/28 (7%)    0/35 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   717          704          555          574       |   718          704          521          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.241      P=0.480N     P=0.525N     P=0.476    |  P=0.114N     P=0.461      P=0.475N     P=0.266N   |
|INCIDENTAL TUMOR       |  P=0.282      P=0.553N     P=0.479N     P=0.504    |  P=0.121N     P=0.448      P=0.450N     P=0.268N   |
|LOGISTIC REGRESSION    |  P=0.265      P=0.489N     P=0.502N     P=0.500    |  P=0.107N     P=0.297      P=0.470N     P=0.256N   |
|COCHRAN-ARMITAGE       |  P=0.263                                           |  P=0.107N                                          |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.500    |               P=0.500      P=0.500N     P=0.247N   |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05033 TEST: 01                                                 PAGE  14
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.1% LM      1.0% MM      4.0% HM   |   CONTROL      0.1% LF      1.0% MF      4.0% HF   |
|                       |   UM                                               |   UF                                               |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Neurofibrosarcoma, Fibrosarcoma, Sarcoma,                                                                                   |
|     Neurofibroma, or Fibroma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    2/50 (4%)    2/50 (4%)    4/50 (8%)  |  2/50 (4%)    3/50 (6%)    2/50 (4%)    1/50 (2%)  |
|ADJUSTED (b)           |   8.9%         6.2%         5.0%        10.7%      |   6.3%        10.2%         4.1%         2.0%      |
|TERMINAL (d)           |  1/26 (4%)    0/28 (0%)    0/25 (0%)    1/23 (4%)  |  1/30 (3%)    2/28 (7%)    0/35 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   458          704          555          555       |   718          704          441          284       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.282      P=0.474N     P=0.519N     P=0.476    |  P=0.314N     P=0.461      P=0.672N     P=0.527N   |
|INCIDENTAL TUMOR       |  P=0.313      P=0.529N     P=0.484N     P=0.415    |  P=0.234N     P=0.448      P=0.607N     P=0.268N   |
|LOGISTIC REGRESSION    |  P=0.318      P=0.509N     P=0.523N     P=0.501    |  P=0.195N     P=0.297      P=0.608N     P=0.339N   |
|COCHRAN-ARMITAGE       |  P=0.304                                           |  P=0.297N                                          |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.500    |               P=0.500      P=0.691N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 44/50 (88%)  43/46 (93%)  45/48 (94%)  45/50 (90%) |                                                    |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%      |                                                    |
|TERMINAL (d)           | 26/26 (100%) 26/26 (100%) 24/24 (100%) 23/23 (100%)|                                                    |
|FIRST INCIDENCE (DAYS) |   573          509          420          555       |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.252      P=0.477N     P=0.341      P=0.335    |                                                    |
|INCIDENTAL TUMOR       |  P=0.598      P=0.295      P=0.321      P=0.481    |                                                    |
|LOGISTIC REGRESSION    |  P=0.617      P=0.226      P=0.218      P=0.521    |                                                    |
|COCHRAN-ARMITAGE       |  P=0.521N                                          |                                                    |
|FISHER EXACT           |               P=0.287      P=0.264      P=0.500    |                                                    |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05033 TEST: 01                                                 PAGE  15
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.1% LM      1.0% MM      4.0% HM   |   CONTROL      0.1% LF      1.0% MF      4.0% HF   |
|                       |   UM                                               |   UF                                               |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/50 (8%)    1/17 (6%)    4/22 (18%)   1/49 (2%)  |  6/50 (12%)   3/43 (7%)    4/47 (9%)    2/50 (4%)  |
|ADJUSTED (b)           |  12.1%        25.0%        31.8%         2.6%      |  20.0%        12.5%        11.8%         6.4%      |
|TERMINAL (d)           |  1/26 (4%)    1/4 (25%)    1/4 (25%)    0/23 (0%)  |  6/30 (20%)   3/24 (13%)   3/32 (9%)    1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |   654          724 (T)      624          676       |   723 (T)      723 (T)      709          688       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.205N     P=0.390N     P=0.401      P=0.189N   |  P=0.179N     P=0.358N     P=0.325N     P=0.154N   |
|INCIDENTAL TUMOR       |  P=0.051N     P=0.488      P=0.169      P=0.102N   |  P=0.176N     P=0.358N     P=0.356N     P=0.161N   |
|LOGISTIC REGRESSION    |  P=0.094N     P=0.676      P=0.100      P=0.181N   |  P=0.171N     P=0.358N     P=0.351N     P=0.161N   |
|COCHRAN-ARMITAGE       |  P=0.127N                                          |  P=0.162N                                          |
|FISHER EXACT           |               P=0.625N     P=0.192      P=0.187N   |               P=0.324N     P=0.410N     P=0.134N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    2/17 (12%)   1/22 (5%)    0/49 (0%)  |  2/50 (4%)    3/43 (7%)    2/47 (4%)    1/50 (2%)  |
|ADJUSTED (b)           |   3.8%        26.5%         3.0%         0.0%      |   5.6%        12.5%         5.7%         3.6%      |
|TERMINAL (d)           |  1/26 (4%)    1/4 (25%)    0/4 (0%)     0/23 (0%)  |  1/30 (3%)    3/24 (13%)   1/32 (3%)    1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |   724 (T)      509          684          ---       |   660          723 (T)      707          723 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.178N     P=0.145      P=0.592      P=0.524N   |  P=0.294N     P=0.408      P=0.666N     P=0.528N   |
|INCIDENTAL TUMOR       |  P=0.155N     P=0.176      P=0.465      P=0.524N   |  P=0.286N     P=0.372      P=0.634      P=0.537N   |
|LOGISTIC REGRESSION    |  P=0.153N     P=0.162      P=0.454      P=0.524N   |  P=0.283N     P=0.372      P=0.669      P=0.521N   |
|COCHRAN-ARMITAGE       |  P=0.153N                                          |  P=0.271N                                          |
|FISHER EXACT           |               P=0.156      P=0.521      P=0.505N   |               P=0.428      P=0.668      P=0.500N   |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05033 TEST: 01                                                 PAGE  16
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.1% LM      1.0% MM      4.0% HM   |   CONTROL      0.1% LF      1.0% MF      4.0% HF   |
|                       |   UM                                               |   UF                                               |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/50 (10%)   3/17 (18%)   4/22 (18%)   1/49 (2%)  |  8/50 (16%)   6/43 (14%)   6/47 (13%)   3/50 (6%)  |
|ADJUSTED (b)           |  15.6%        51.0%        31.8%         2.6%      |  25.2%        25.0%        17.1%         9.9%      |
|TERMINAL (d)           |  2/26 (8%)    2/4 (50%)    1/4 (25%)    0/23 (0%)  |  7/30 (23%)   6/24 (25%)   4/32 (13%)   2/28 (7%)  |
|FIRST INCIDENCE (DAYS) |   654          509          624          676       |   660          723 (T)      707          688       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.075N     P=0.516      P=0.443      P=0.116N   |  P=0.095N     P=0.561N     P=0.334N     P=0.123N   |
|INCIDENTAL TUMOR       |  P=0.018N*    P=0.102      P=0.208      P=0.060N   |  P=0.091N     P=0.585N     P=0.413N     P=0.129N   |
|LOGISTIC REGRESSION    |  P=0.030N*    P=0.218      P=0.140      P=0.103N   |  P=0.087N     P=0.609      P=0.408N     P=0.127N   |
|COCHRAN-ARMITAGE       |  P=0.040N*                                         |  P=0.082N                                          |
|FISHER EXACT           |               P=0.326      P=0.273      P=0.107N   |               P=0.508N     P=0.436N     P=0.100N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/17 (0%)    0/22 (0%)    2/49 (4%)  |  0/50 (0%)    0/43 (0%)    0/47 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |   3.8%         0.0%         0.0%         4.9%      |   0.0%         0.0%         0.0%         3.6%      |
|TERMINAL (d)           |  1/26 (4%)    0/4 (0%)     0/4 (0%)     0/23 (0%)  |  0/30 (0%)    0/24 (0%)    0/32 (0%)    1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |   724 (T)      ---          ---          626       |   ---          ---          ---          723 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.237      P=0.860N     P=0.860N     P=0.501    |  P=0.224        (e)          (e)        P=0.486    |
|INCIDENTAL TUMOR       |  P=0.282      P=0.860N     P=0.860N     P=0.476    |  P=0.224        (e)          (e)        P=0.486    |
|LOGISTIC REGRESSION    |  P=0.303      P=0.860N     P=0.860N     P=0.491    |  P=0.224        (e)          (e)        P=0.486    |
|COCHRAN-ARMITAGE       |  P=0.290                                           |  P=0.237                                           |
|FISHER EXACT           |               P=0.746N     P=0.694N     P=0.492    |                 (e)          (e)        P=0.500    |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05033 TEST: 01                                                 PAGE  17
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.1% LM      1.0% MM      4.0% HM   |   CONTROL      0.1% LF      1.0% MF      4.0% HF   |
|                       |   UM                                               |   UF                                               |
|=================================================================================================================================|
|                                                                                                                                 |
|Tongue                                                                                                                           |
|     Squamous Cell Carcinoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   0.0%         0.0%         0.0%         4.7%      |
|TERMINAL (d)           |  0/26 (0%)    0/28 (0%)    0/25 (0%)    0/23 (0%)  |  0/30 (0%)    0/28 (0%)    0/35 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   ---          ---          ---          492       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.039 *      (e)          (e)        P=0.227    |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.035 *      (e)          (e)        P=0.290    |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.067        (e)          (e)        P=0.327    |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.042 *                                         |
|FISHER EXACT           |                 (e)          (e)          (e)      |                 (e)          (e)        P=0.247    |
|=================================================================================================================================|
|                                                                                                                                 |
|Tongue                                                                                                                           |
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         2.6%      |   0.0%         0.0%         0.0%         4.7%      |
|TERMINAL (d)           |  0/26 (0%)    0/28 (0%)    0/25 (0%)    0/23 (0%)  |  0/30 (0%)    0/28 (0%)    0/35 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          674       |   ---          ---          ---          492       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.241        (e)          (e)        P=0.522    |  P=0.039 *      (e)          (e)        P=0.227    |
|INCIDENTAL TUMOR       |  P=0.312        (e)          (e)        P=0.576    |  P=0.035 *      (e)          (e)        P=0.290    |
|LOGISTIC REGRESSION    |  P=0.225        (e)          (e)        P=0.500    |  P=0.067        (e)          (e)        P=0.327    |
|COCHRAN-ARMITAGE       |  P=0.224                                           |  P=0.042 *                                         |
|FISHER EXACT           |                 (e)          (e)        P=0.500    |                 (e)          (e)        P=0.247    |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05033 TEST: 01                                                 PAGE  18
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.1% LM      1.0% MM      4.0% HM   |   CONTROL      0.1% LF      1.0% MF      4.0% HF   |
|                       |   UM                                               |   UF                                               |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  7/50 (14%)   9/50 (18%)  16/50 (32%)  11/50 (22%) |
|ADJUSTED (b)           |                                                    |  18.8%        27.7%        41.4%        33.2%      |
|TERMINAL (d)           |                                                    |  4/30 (13%)   6/28 (21%)  13/35 (37%)   8/28 (29%) |
|FIRST INCIDENCE (DAYS) |                                                    |   597          515          521          284       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.261      P=0.334      P=0.059      P=0.178    |
|INCIDENTAL TUMOR       |                                                    |  P=0.333      P=0.422      P=0.035 *    P=0.312    |
|LOGISTIC REGRESSION    |                                                    |  P=0.310      P=0.399      P=0.028 *    P=0.265    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.314                                           |
|FISHER EXACT           |                                                    |               P=0.393      P=0.028 *    P=0.218    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  0/50 (0%)    2/50 (4%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |                                                    |   0.0%         4.8%         2.9%         0.0%      |
|TERMINAL (d)           |                                                    |  0/30 (0%)    0/28 (0%)    1/35 (3%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   ---          543          723 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.354N     P=0.229      P=0.531        (e)      |
|INCIDENTAL TUMOR       |                                                    |  P=0.370N     P=0.350      P=0.531        (e)      |
|LOGISTIC REGRESSION    |                                                    |  P=0.315N     P=0.280      P=0.531        (e)      |
|COCHRAN-ARMITAGE       |                                                    |  P=0.343N                                          |
|FISHER EXACT           |                                                    |               P=0.247      P=0.500        (e)      |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05033 TEST: 01                                                 PAGE  19
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.1% LM      1.0% MM      4.0% HM   |   CONTROL      0.1% LF      1.0% MF      4.0% HF   |
|                       |   UM                                               |   UF                                               |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  7/50 (14%)  11/50 (22%)  17/50 (34%)  11/50 (22%) |
|ADJUSTED (b)           |                                                    |  18.8%        31.2%        44.0%        33.2%      |
|TERMINAL (d)           |                                                    |  4/30 (13%)   6/28 (21%)  14/35 (40%)   8/28 (29%) |
|FIRST INCIDENCE (DAYS) |                                                    |   597          515          521          284       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.360      P=0.182      P=0.040 *    P=0.178    |
|INCIDENTAL TUMOR       |                                                    |  P=0.433      P=0.281      P=0.023 *    P=0.312    |
|LOGISTIC REGRESSION    |                                                    |  P=0.424      P=0.246      P=0.017 *    P=0.265    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.420                                           |
|FISHER EXACT           |                                                    |               P=0.218      P=0.017 *    P=0.218    |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Squamous Cell Carcinoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   2.4%         6.3%         0.0%         0.0%      |
|TERMINAL (d)           |  0/26 (0%)    0/28 (0%)    0/25 (0%)    0/23 (0%)  |  0/30 (0%)    0/28 (0%)    0/35 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   660          683          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.228N     P=0.458      P=0.495N     P=0.520N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.238N     P=0.434      P=0.581N     P=0.536N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.221N     P=0.506      P=0.486N     P=0.481N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.223N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.500      P=0.500N     P=0.500N   |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05033 TEST: 01                                                 PAGE  20
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.1% LM      1.0% MM      4.0% HM   |   CONTROL      0.1% LF      1.0% MF      4.0% HF   |
|                       |   UM                                               |   UF                                               |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)  |  1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         6.7%         0.0%      |   2.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/26 (0%)    0/28 (0%)    1/25 (4%)    0/23 (0%)  |  0/30 (0%)    0/28 (0%)    0/35 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          674          ---       |   422          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.667N       (e)        P=0.239        (e)      |  P=0.558N     P=0.500N     P=0.504N     P=0.504N   |
|INCIDENTAL TUMOR       |  P=0.615N       (e)        P=0.235        (e)      |  P=0.587N     P=0.227N     P=0.362N     P=0.362N   |
|LOGISTIC REGRESSION    |  P=0.661N       (e)        P=0.235        (e)      |  P=0.318N     P=0.227N     P=0.249N     P=0.231N   |
|COCHRAN-ARMITAGE       |  P=0.661N                                          |  P=0.555N                                          |
|FISHER EXACT           |                 (e)        P=0.247        (e)      |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear,                                                                              |
|     or Undifferentiated                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 16/50 (32%)  18/50 (36%)  22/50 (44%)  13/50 (26%) |  9/50 (18%)  10/50 (20%)  13/50 (26%)  12/50 (24%) |
|ADJUSTED (b)           |  42.4%        39.2%        58.8%        42.5%      |  22.8%        26.3%        29.6%        32.6%      |
|TERMINAL (d)           |  6/26 (23%)   2/28 (7%)   11/25 (44%)   7/23 (30%) |  3/30 (10%)   3/28 (11%)   5/35 (14%)   5/28 (18%) |
|FIRST INCIDENCE (DAYS) |   590          546          549          662       |   422          504          548          623       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.257N     P=0.470      P=0.168      P=0.393N   |  P=0.285      P=0.423      P=0.323      P=0.264    |
|INCIDENTAL TUMOR       |  P=0.138N     P=0.360      P=0.183      P=0.286N   |  P=0.304      P=0.607      P=0.105      P=0.296    |
|LOGISTIC REGRESSION    |  P=0.167N     P=0.334      P=0.151      P=0.274N   |  P=0.353      P=0.597N     P=0.258      P=0.331    |
|COCHRAN-ARMITAGE       |  P=0.164N                                          |  P=0.322                                           |
|FISHER EXACT           |               P=0.417      P=0.151      P=0.330N   |               P=0.500      P=0.235      P=0.312    |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05033 TEST: 01                                                 PAGE  21
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.1% LM      1.0% MM      4.0% HM   |   CONTROL      0.1% LF      1.0% MF      4.0% HF   |
|                       |   UM                                               |   UF                                               |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma And Histiocytic Sarcoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    2/50 (4%)    2/50 (4%)    0/50 (0%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   8.3%         5.5%         6.2%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/26 (0%)    1/28 (4%)    1/25 (4%)    0/23 (0%)  |  0/30 (0%)    0/28 (0%)    0/35 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   654          458          592          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.117N     P=0.488N     P=0.514N     P=0.118N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.101N     P=0.529N     P=0.483N     P=0.060N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.102N     P=0.533N     P=0.502N     P=0.121N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.107N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.121N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        |
|     NOS, or Undifferentiated Cell Type                                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    2/50 (4%)    2/50 (4%)    0/50 (0%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   8.3%         5.5%         6.2%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/26 (0%)    1/28 (4%)    1/25 (4%)    0/23 (0%)  |  0/30 (0%)    0/28 (0%)    0/35 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   654          458          592          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.117N     P=0.488N     P=0.514N     P=0.118N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.101N     P=0.529N     P=0.483N     P=0.060N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.102N     P=0.533N     P=0.502N     P=0.121N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.107N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.121N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05033 TEST: 01                                                 PAGE  22
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.1% LM      1.0% MM      4.0% HM   |   CONTROL      0.1% LF      1.0% MF      4.0% HF   |
|                       |   UM                                               |   UF                                               |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma Benign, Malignant, NOS                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/50 (8%)    4/50 (8%)    3/50 (6%)    1/50 (2%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |  10.8%        11.8%         6.9%         3.6%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/26 (4%)    2/28 (7%)    0/25 (0%)    0/23 (0%)  |  0/30 (0%)    0/28 (0%)    0/35 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   573          599          420          704       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.133N     P=0.626N     P=0.501N     P=0.192N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.133N     P=0.640N     P=0.451N     P=0.194N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.111N     P=0.635      P=0.534N     P=0.179N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.120N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.643N     P=0.500N     P=0.181N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 49/50 (98%)  48/50 (96%)  50/50 (100%) 48/50 (96%) | 49/50 (98%)  44/50 (88%)  42/50 (84%)  35/50 (70%) |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%      |  98.0%        93.6%        87.5%        84.9%      |
|TERMINAL (d)           | 26/26 (100%) 28/28 (100%) 25/25 (100%) 23/23 (100%)| 29/30 (97%)  25/28 (89%)  29/35 (83%)  22/28 (79%) |
|FIRST INCIDENCE (DAYS) |   226          509          420          422       |   422          497          441          284       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.340      P=0.359N     P=0.413      P=0.467    |  P=0.052N     P=0.503N     P=0.041N*    P=0.060N   |
|INCIDENTAL TUMOR       |  P=0.659N     P=0.616N     P=0.500      P=0.599N   |  P<0.001N**   P=0.103N     P=0.039N*    P<0.001N** |
|LOGISTIC REGRESSION    |  P=0.643      P=0.307N     P=0.627      P=0.612N   |  P<0.001N**   P=0.073N     P=0.021N*    P<0.001N** |
|COCHRAN-ARMITAGE       |  P=0.464N                                          |  P<0.001N**                                        |
|FISHER EXACT           |               P=0.500N     P=0.500      P=0.500N   |               P=0.056N     P=0.015N*    P<0.001N** |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05033 TEST: 01                                                 PAGE  23
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      0.1% LM      1.0% MM      4.0% HM   |   CONTROL      0.1% LF      1.0% MF      4.0% HF   |
|                       |   UM                                               |   UF                                               |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 29/50 (58%)  27/50 (54%)  32/50 (64%)  21/50 (42%) | 15/50 (30%)  19/50 (38%)  19/50 (38%)  20/50 (40%) |
|ADJUSTED (b)           |  64.9%        54.7%        73.5%        57.0%      |  36.4%        44.0%        42.5%        46.1%      |
|TERMINAL (d)           | 11/26 (42%)   6/28 (21%)  14/25 (56%)   9/23 (39%) |  6/30 (20%)   6/28 (21%)  10/35 (29%)   6/28 (21%) |
|FIRST INCIDENCE (DAYS) |   458          458          420          422       |   422          497          441          284       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.170N     P=0.392N     P=0.339      P=0.177N   |  P=0.253      P=0.214      P=0.396      P=0.175    |
|INCIDENTAL TUMOR       |  P=0.048N*    P=0.401N     P=0.403      P=0.087N   |  P=0.281      P=0.394      P=0.153      P=0.231    |
|LOGISTIC REGRESSION    |  P=0.074N     P=0.438N     P=0.340      P=0.100N   |  P=0.357      P=0.419      P=0.284      P=0.288    |
|COCHRAN-ARMITAGE       |  P=0.050N*                                         |  P=0.283                                           |
|FISHER EXACT           |               P=0.420N     P=0.341      P=0.081N   |               P=0.263      P=0.263      P=0.201    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 50/50 (100%) 50/50 (100%) 50/50 (100%) 48/50 (96%) | 49/50 (98%)  48/50 (96%)  43/50 (86%)  45/50 (90%) |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%      |  98.0%        96.0%        87.8%        93.7%      |
|TERMINAL (d)           | 26/26 (100%) 28/28 (100%) 25/25 (100%) 23/23 (100%)| 29/30 (97%)  26/28 (93%)  29/35 (83%)  25/28 (89%) |
|FIRST INCIDENCE (DAYS) |   226          458          420          422       |   422          497          441          284       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.427      P=0.419N     P=0.470      P=0.523    |  P=0.494N     P=0.374      P=0.059N     P=0.541N   |
|INCIDENTAL TUMOR       |  P=0.268N       (e)          (e)        P=0.362N   |  P=0.154N     P=0.476N     P=0.084N     P=0.112N   |
|LOGISTIC REGRESSION    |  P=0.058N       (e)          (e)        P=0.162N   |  P=0.189N     P=0.476N     P=0.035N*    P=0.107N   |
|COCHRAN-ARMITAGE       |  P=0.042N*                                         |  P=0.138N                                          |
|FISHER EXACT           |               P=1.000N     P=1.000N     P=0.247N   |               P=0.500N     P=0.030N*    P=0.102N   |
|=================================================================================================================================|
 
         DATE: 09/04/94                     EXPERIMENT: 05033 TEST: 01                                                 PAGE  24
                                STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
 
                                                 TERMINAL SACRIFICE AT 104 WEEKS
 
 
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
 
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.