TDMS Study 05033-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason QUERCETIN DATE: 09/04/94
EXPERIMENT: 05033 TEST: 01 TIME: 20:45:56
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01CP9561903 ROUTE: DOSED FEED NTP C#: 60106
PATHOLOGIST: R. FLEISCHMAN S. EUSTIS CAS: 117-39-5
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason QUERCETIN DATE: 09/04/94
EXPERIMENT: 05033 TEST: 01 TIME: 20:45:56
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01CP9561903 ROUTE: DOSED FEED NTP C#: 60106
PATHOLOGIST: R. FLEISCHMAN S. EUSTIS CAS: 117-39-5
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Bone Marrow
Brain
Clitoral Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Mason QUERCETIN DATE: 09/04/94
EXPERIMENT: 05033 TEST: 01 TIME: 20:45:56
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01CP9561903 ROUTE: DOSED FEED NTP C#: 60106
PATHOLOGIST: R. FLEISCHMAN S. EUSTIS CAS: 117-39-5
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF QUERCETIN
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma Benign
Pheochromocytoma: Benign, Complex, Malignant, NOS
Clitoral/Preputial Gland Carcinoma
Islets, Pancreatic Adenoma
Carcinoma or Adenoma
Kidney: Renal Tubule Adenoma
Carcinoma or Adenoma
Thyroid Gland: C-Cell Carcinoma or Adenoma
All Organs Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Medulla Pheochromocytoma Benign
Pheochromocytoma: Benign, Complex, Malignant, NOS
Clitoral/Preputial Gland Adenoma
Islets, Pancreatic Adenoma
Carcinoma or Adenoma
Lung Alveolar/Bronchiolar Adenoma
Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
Mammary Gland Fibroadenoma
Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip)
Squamous Cell Carcinoma
Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Tongue Squamous Cell Carcinoma
Squamous Cell Carcinoma or Papilloma Squamous
Uterus Polyp Stromal
Sarcoma Stromal or Polyp Stromal
All Organs Benign Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 09/04/94 EXPERIMENT: 05033 TEST: 01 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.1% LM 1.0% MM 4.0% HM | CONTROL 0.1% LF 1.0% MF 4.0% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 12/50 (24%) 4/18 (22%) 10/21 (48%) 11/49 (22%) | 3/49 (6%) 0/13 (0%) 3/12 (25%) 1/50 (2%) |
|ADJUSTED (b) | 37.6% 52.9% 74.9% 36.0% | 7.8% 0.0% 100.0% 3.6% |
|TERMINAL (d) | 7/26 (27%) 2/4 (50%) 5/7 (71%) 6/23 (26%) | 1/30 (3%) 0/0 3/3 (100%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | 575 620 555 662 | 625 --- 723 (T) 723 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.545N P=0.435N P=0.142 P=0.568N | P=0.239N P=0.267N P=0.101 P=0.340N |
|INCIDENTAL TUMOR | P=0.247N P=0.327 P=0.016 * P=0.459N | P=0.207N P=0.423N P=0.022 * P=0.313N |
|LOGISTIC REGRESSION | P=0.256N P=0.342 P=0.009 ** P=0.503N | P=0.212N P=0.367N P=0.018 * P=0.291N |
|COCHRAN-ARMITAGE | P=0.385N | P=0.234N |
|FISHER EXACT | P=0.578N P=0.048 * P=0.522N | P=0.487N P=0.084 P=0.301N |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/18 (0%) 1/21 (5%) 2/49 (4%) | 1/49 (2%) 1/13 (8%) 0/12 (0%) 0/50 (0%) |
|ADJUSTED (b) | 3.3% 0.0% 14.3% 6.3% | 3.3% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/26 (0%) 0/4 (0%) 1/7 (14%) 0/23 (0%) | 1/30 (3%) 0/0 0/3 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 717 --- 724 (T) 662 | 723 (T) 497 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.268 P=0.493N P=0.602 P=0.492 | P=0.273N P=0.504 P=0.923N P=0.514N |
|INCIDENTAL TUMOR | P=0.555 P=0.860N P=0.386 P=0.615 | P=0.266N (e) P=0.923N P=0.514N |
|LOGISTIC REGRESSION | P=0.432 P=0.824N P=0.429 P=0.497 | P=0.229N P=0.853N P=0.923N P=0.514N |
|COCHRAN-ARMITAGE | P=0.374 | P=0.244N |
|FISHER EXACT | P=0.735N P=0.507 P=0.492 | P=0.378 P=0.803N P=0.495N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05033 TEST: 01 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.1% LM 1.0% MM 4.0% HM | CONTROL 0.1% LF 1.0% MF 4.0% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 13/50 (26%) 4/18 (22%) 11/21 (52%) 12/49 (24%) | 3/49 (6%) 1/13 (8%) 3/12 (25%) 1/50 (2%) |
|ADJUSTED (b) | 39.7% 52.9% 87.4% 38.5% | 7.8% 0.0% 100.0% 3.6% |
|TERMINAL (d) | 7/26 (27%) 2/4 (50%) 6/7 (86%) 6/23 (26%) | 1/30 (3%) 0/0 3/3 (100%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | 575 620 555 662 | 625 497 723 (T) 723 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.539 P=0.322N P=0.115 P=0.574N | P=0.185N P=0.526N P=0.101 P=0.340N |
|INCIDENTAL TUMOR | P=0.223N P=0.366 P=0.006 ** P=0.430N | P=0.157N P=0.423N P=0.022 * P=0.313N |
|LOGISTIC REGRESSION | P=0.247N P=0.389 P=0.003 ** P=0.501N | P=0.158N P=0.339N P=0.018 * P=0.291N |
|COCHRAN-ARMITAGE | P=0.398N | P=0.160N |
|FISHER EXACT | P=0.510N P=0.032 * P=0.523N | P=0.620 P=0.084 P=0.301N |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/13 (15%) 5/22 (23%) 3/19 (16%) 1/15 (7%) | 4/14 (29%) 4/20 (20%) 3/14 (21%) 4/12 (33%) |
|ADJUSTED (b) | 4.8% 25.3% 60.0% 25.0% | 80.0% 39.7% 35.1% 100.0% |
|TERMINAL (d) | 0/1 (0%) 1/6 (17%) 3/5 (60%) 1/4 (25%) | 4/5 (80%) 3/8 (38%) 2/6 (33%) 2/2 (100%) |
|FIRST INCIDENCE (DAYS) | 562 618 724 (T) 724 (T) | 723 (T) 721 707 632 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.136N P=0.317 P=0.502N P=0.344N | P=0.108 P=0.387N P=0.379N P=0.163 |
|INCIDENTAL TUMOR | P=0.159N P=0.532 P=0.474N P=0.350N | P=0.046 * P=0.477N P=0.431N P=0.108 |
|LOGISTIC REGRESSION | P=0.158N P=0.599 P=0.531N P=0.402N | P=0.040 * P=0.257N P=0.373N P=0.084 |
|COCHRAN-ARMITAGE | P=0.200N | P=0.354 |
|FISHER EXACT | P=0.475 P=0.683 P=0.444N | P=0.428N P=0.500N P=0.563 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05033 TEST: 01 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.1% LM 1.0% MM 4.0% HM | CONTROL 0.1% LF 1.0% MF 4.0% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/13 (8%) 0/22 (0%) 1/19 (5%) 3/15 (20%) | 1/14 (7%) 1/20 (5%) 2/14 (14%) 0/12 (0%) |
|ADJUSTED (b) | 2.3% 0.0% 20.0% 29.0% | 2.9% 12.5% 18.8% 0.0% |
|TERMINAL (d) | 0/1 (0%) 0/6 (0%) 1/5 (20%) 1/4 (25%) | 0/5 (0%) 1/8 (13%) 1/6 (17%) 0/2 (0%) |
|FIRST INCIDENCE (DAYS) | 620 --- 724 (T) 626 | 700 723 (T) 697 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.085 P=0.514N P=0.613N P=0.426 | P=0.460N P=0.728N P=0.543 P=0.524N |
|INCIDENTAL TUMOR | P=0.044 * P=0.477N P=0.571N P=0.340 | P=0.576N P=0.713 P=0.421 P=0.718N |
|LOGISTIC REGRESSION | P=0.049 * P=0.408N P=0.598N P=0.457 | P=0.567N P=0.714N P=0.494 P=0.651N |
|COCHRAN-ARMITAGE | P=0.045 * | P=0.410N |
|FISHER EXACT | P=0.371N P=0.655N P=0.356 | P=0.661N P=0.500 P=0.538N |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/13 (23%) 5/22 (23%) 4/19 (21%) 4/15 (27%) | 5/14 (36%) 5/20 (25%) 5/14 (36%) 4/12 (33%) |
|ADJUSTED (b) | 7.0% 25.3% 80.0% 52.6% | 80.6% 51.7% 52.6% 100.0% |
|TERMINAL (d) | 0/1 (0%) 1/6 (17%) 4/5 (80%) 2/4 (50%) | 4/5 (80%) 4/8 (50%) 3/6 (50%) 2/2 (100%) |
|FIRST INCIDENCE (DAYS) | 562 618 724 (T) 626 | 700 721 697 632 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.560N P=0.463 P=0.374N P=0.614N | P=0.235 P=0.370N P=0.533N P=0.358 |
|INCIDENTAL TUMOR | P=0.537 P=0.629N P=0.323N P=0.658 | P=0.073 P=0.530N P=0.681N P=0.188 |
|LOGISTIC REGRESSION | P=0.545 P=0.549N P=0.396N P=0.666N | P=0.075 P=0.333N P=0.639N P=0.151 |
|COCHRAN-ARMITAGE | P=0.487 | P=0.519 |
|FISHER EXACT | P=0.645N P=0.611N P=0.588 | P=0.382N P=0.653N P=0.613N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05033 TEST: 01 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.1% LM 1.0% MM 4.0% HM | CONTROL 0.1% LF 1.0% MF 4.0% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/47 (0%) 2/15 (13%) 0/13 (0%) 3/41 (7%) | 2/44 (5%) 3/15 (20%) 1/8 (13%) 0/49 (0%) |
|ADJUSTED (b) | 0.0% 51.5% 0.0% 11.9% | 6.3% 75.0% 0.0% 0.0% |
|TERMINAL (d) | 0/25 (0%) 1/2 (50%) 0/0 1/18 (6%) | 1/27 (4%) 3/4 (75%) 0/0 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | --- 704 --- 694 | 687 723 (T) 666 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.164 P=0.053 (e) P=0.101 | P=0.051N P=0.029 * P=0.746N P=0.245N |
|INCIDENTAL TUMOR | P=0.425 P<0.001 ** (e) P=0.141 | P=0.030N* P<0.001 ** P=0.227 P=0.224N |
|LOGISTIC REGRESSION | P=0.325 P<0.001 ** (e) P=0.100 | P=0.035N* P=0.003 ** P=0.255 P=0.225N |
|COCHRAN-ARMITAGE | P=0.228 | P=0.044N* |
|FISHER EXACT | P=0.056 (e) P=0.097 | P=0.099 P=0.401 P=0.221N |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/47 (0%) 2/15 (13%) 1/13 (8%) 3/41 (7%) | 2/44 (5%) 3/15 (20%) 1/8 (13%) 0/49 (0%) |
|ADJUSTED (b) | 0.0% 51.5% 0.0% 11.9% | 6.3% 75.0% 0.0% 0.0% |
|TERMINAL (d) | 0/25 (0%) 1/2 (50%) 0/0 1/18 (6%) | 1/27 (4%) 3/4 (75%) 0/0 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | --- 704 699 694 | 687 723 (T) 666 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.197 P=0.053 P=0.487 P=0.101 | P=0.051N P=0.029 * P=0.746N P=0.245N |
|INCIDENTAL TUMOR | P=0.537 P<0.001 ** P=0.056 P=0.141 | P=0.030N* P<0.001 ** P=0.227 P=0.224N |
|LOGISTIC REGRESSION | P=0.398 P<0.001 ** P=0.053 P=0.100 | P=0.035N* P=0.003 ** P=0.255 P=0.225N |
|COCHRAN-ARMITAGE | P=0.287 | P=0.044N* |
|FISHER EXACT | P=0.056 P=0.217 P=0.097 | P=0.099 P=0.401 P=0.221N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05033 TEST: 01 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.1% LM 1.0% MM 4.0% HM | CONTROL 0.1% LF 1.0% MF 4.0% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 3/50 (6%) | 0/49 (0%) 0/49 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 11.1% | 0.0% 0.0% 2.9% 0.0% |
|TERMINAL (d) | 0/26 (0%) 0/28 (0%) 0/25 (0%) 2/23 (9%) | 0/30 (0%) 0/28 (0%) 1/35 (3%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 676 | --- --- 723 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.007 ** (e) (e) P=0.114 | P=0.789N (e) P=0.531 (e) |
|INCIDENTAL TUMOR | P=0.011 * (e) (e) P=0.129 | P=0.789N (e) P=0.531 (e) |
|LOGISTIC REGRESSION | P=0.009 ** (e) (e) P=0.122 | P=0.789N (e) P=0.531 (e) |
|COCHRAN-ARMITAGE | P=0.008 ** | P=0.773N |
|FISHER EXACT | (e) (e) P=0.121 | (e) P=0.505 (e) |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 4/50 (8%) | 0/49 (0%) 0/49 (0%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 15.3% | 0.0% 0.0% 2.9% 0.0% |
|TERMINAL (d) | 0/26 (0%) 0/28 (0%) 0/25 (0%) 3/23 (13%) | 0/30 (0%) 0/28 (0%) 1/35 (3%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 676 | --- --- 723 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.001 ** (e) (e) P=0.056 | P=0.789N (e) P=0.531 (e) |
|INCIDENTAL TUMOR | P=0.002 ** (e) (e) P=0.063 | P=0.789N (e) P=0.531 (e) |
|LOGISTIC REGRESSION | P=0.002 ** (e) (e) P=0.064 | P=0.789N (e) P=0.531 (e) |
|COCHRAN-ARMITAGE | P=0.002 ** | P=0.773N |
|FISHER EXACT | (e) (e) P=0.059 | (e) P=0.505 (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05033 TEST: 01 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.1% LM 1.0% MM 4.0% HM | CONTROL 0.1% LF 1.0% MF 4.0% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 3/50 (6%) 4/50 (8%) 0/50 (0%) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 11.5% 10.7% 16.0% 0.0% | 0.0% 3.6% 0.0% 3.6% |
|TERMINAL (d) | 3/26 (12%) 3/28 (11%) 4/25 (16%) 0/23 (0%) | 0/30 (0%) 1/28 (4%) 0/35 (0%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | 724 (T) 724 (T) 724 (T) --- | --- 723 (T) --- 723 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.105N P=0.631N P=0.478 P=0.142N | P=0.478 P=0.486 (e) P=0.486 |
|INCIDENTAL TUMOR | P=0.105N P=0.631N P=0.478 P=0.142N | P=0.478 P=0.486 (e) P=0.486 |
|LOGISTIC REGRESSION | P=0.105N P=0.631N P=0.478 P=0.142N | P=0.478 P=0.486 (e) P=0.486 |
|COCHRAN-ARMITAGE | P=0.082N | P=0.491 |
|FISHER EXACT | P=0.661N P=0.500 P=0.121N | P=0.500 (e) P=0.500 |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma or Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 4/50 (8%) 4/50 (8%) 1/50 (2%) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 11.5% 14.3% 16.0% 4.3% | 0.0% 3.6% 0.0% 3.6% |
|TERMINAL (d) | 3/26 (12%) 4/28 (14%) 4/25 (16%) 1/23 (4%) | 0/30 (0%) 1/28 (4%) 0/35 (0%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | 724 (T) 724 (T) 724 (T) 724 (T) | --- 723 (T) --- 723 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.208N P=0.541 P=0.478 P=0.348N | P=0.478 P=0.486 (e) P=0.486 |
|INCIDENTAL TUMOR | P=0.208N P=0.541 P=0.478 P=0.348N | P=0.478 P=0.486 (e) P=0.486 |
|LOGISTIC REGRESSION | P=0.208N P=0.541 P=0.478 P=0.348N | P=0.478 P=0.486 (e) P=0.486 |
|COCHRAN-ARMITAGE | P=0.161N | P=0.491 |
|FISHER EXACT | P=0.500 P=0.500 P=0.309N | P=0.500 (e) P=0.500 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05033 TEST: 01 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.1% LM 1.0% MM 4.0% HM | CONTROL 0.1% LF 1.0% MF 4.0% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 4/50 (8%) 4/50 (8%) 1/50 (2%) | 0/50 (0%) 1/50 (2%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 11.5% 14.3% 16.0% 4.3% | 0.0% 3.6% 0.0% 3.6% |
|TERMINAL (d) | 3/26 (12%) 4/28 (14%) 4/25 (16%) 1/23 (4%) | 0/30 (0%) 1/28 (4%) 0/35 (0%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | 724 (T) 724 (T) 724 (T) 724 (T) | --- 723 (T) --- 723 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.208N P=0.541 P=0.478 P=0.348N | P=0.478 P=0.486 (e) P=0.486 |
|INCIDENTAL TUMOR | P=0.208N P=0.541 P=0.478 P=0.348N | P=0.478 P=0.486 (e) P=0.486 |
|LOGISTIC REGRESSION | P=0.208N P=0.541 P=0.478 P=0.348N | P=0.478 P=0.486 (e) P=0.486 |
|COCHRAN-ARMITAGE | P=0.161N | P=0.491 |
|FISHER EXACT | P=0.500 P=0.500 P=0.309N | P=0.500 (e) P=0.500 |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/28 (0%) 1/31 (3%) 1/50 (2%) | 5/50 (10%) 0/20 (0%) 1/20 (5%) 0/50 (0%) |
|ADJUSTED (b) | 7.7% 0.0% 2.0% 4.3% | 14.3% 0.0% 12.5% 0.0% |
|TERMINAL (d) | 2/26 (8%) 0/9 (0%) 0/9 (0%) 1/23 (4%) | 3/30 (10%) 0/2 (0%) 1/8 (13%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 724 (T) --- 427 724 (T) | 641 --- 723 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.579N P=0.491N P=0.731N P=0.543N | P=0.052N P=0.219N P=0.371N P=0.044N* |
|INCIDENTAL TUMOR | P=0.634N P=0.491N P=0.731N P=0.543N | P=0.049N* P=0.243N P=0.500N P=0.037N* |
|LOGISTIC REGRESSION | P=0.578N P=0.491N P=0.643N P=0.543N | P=0.050N* P=0.250N P=0.501N P=0.036N* |
|COCHRAN-ARMITAGE | P=0.571N | P=0.055N |
|FISHER EXACT | P=0.408N P=0.675N P=0.500N | P=0.175N P=0.444N P=0.028N* |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05033 TEST: 01 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.1% LM 1.0% MM 4.0% HM | CONTROL 0.1% LF 1.0% MF 4.0% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/28 (0%) 1/31 (3%) 1/50 (2%) | 5/50 (10%) 1/20 (5%) 1/20 (5%) 0/50 (0%) |
|ADJUSTED (b) | 7.7% 0.0% 2.0% 4.3% | 14.3% 2.2% 12.5% 0.0% |
|TERMINAL (d) | 2/26 (8%) 0/9 (0%) 0/9 (0%) 1/23 (4%) | 3/30 (10%) 0/2 (0%) 1/8 (13%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 724 (T) --- 427 724 (T) | 641 548 723 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.579N P=0.491N P=0.731N P=0.543N | P=0.038N* P=0.452N P=0.371N P=0.044N* |
|INCIDENTAL TUMOR | P=0.634N P=0.491N P=0.731N P=0.543N | P=0.033N* P=0.462N P=0.500N P=0.037N* |
|LOGISTIC REGRESSION | P=0.578N P=0.491N P=0.643N P=0.543N | P=0.035N* P=0.394N P=0.501N P=0.036N* |
|COCHRAN-ARMITAGE | P=0.571N | P=0.036N* |
|FISHER EXACT | P=0.408N P=0.675N P=0.500N | P=0.444N P=0.444N P=0.028N* |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 1/50 (2%) 0/50 (0%) 3/50 (6%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 2.5% 0.0% 7.9% 6.0% |
|TERMINAL (d) | 0/26 (0%) 0/28 (0%) 0/25 (0%) 0/23 (0%) | 0/30 (0%) 0/28 (0%) 2/35 (6%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 672 --- 660 686 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.299 P=0.521N P=0.340 P=0.468 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.291 P=0.536N P=0.261 P=0.434 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.307 P=0.488N P=0.304 P=0.492 |
|COCHRAN-ARMITAGE | (e) | P=0.318 |
|FISHER EXACT | (e) (e) (e) | P=0.500N P=0.309 P=0.500 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05033 TEST: 01 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.1% LM 1.0% MM 4.0% HM | CONTROL 0.1% LF 1.0% MF 4.0% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 1/50 (2%) 5/50 (10%) 3/50 (6%) | 29/50 (58%) 27/50 (54%) 16/50 (32%) 9/50 (18%) |
|ADJUSTED (b) | 16.3% 3.6% 17.3% 13.0% | 66.4% 72.3% 38.4% 30.1% |
|TERMINAL (d) | 3/26 (12%) 1/28 (4%) 3/25 (12%) 3/23 (13%) | 16/30 (53%) 18/28 (64%) 10/35 (29%) 8/28 (29%) |
|FIRST INCIDENCE (DAYS) | 590 724 (T) 673 724 (T) | 597 597 605 549 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.590 P=0.094N P=0.612 P=0.401N | P<0.001N** P=0.531 P=0.008N** P<0.001N** |
|INCIDENTAL TUMOR | P=0.567N P=0.100N P=0.629 P=0.413N | P<0.001N** P=0.574N P=0.021N* P<0.001N** |
|LOGISTIC REGRESSION | P=0.546N P=0.100N P=0.624 P=0.350N | P<0.001N** P=0.534N P=0.008N** P<0.001N** |
|COCHRAN-ARMITAGE | P=0.551N | P<0.001N** |
|FISHER EXACT | P=0.102N P=0.630N P=0.357N | P=0.420N P=0.008N** P<0.001N** |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 1/50 (2%) 5/50 (10%) 3/50 (6%) | 30/50 (60%) 27/50 (54%) 17/50 (34%) 11/50 (22%) |
|ADJUSTED (b) | 16.3% 3.6% 17.3% 13.0% | 67.2% 72.3% 40.8% 34.3% |
|TERMINAL (d) | 3/26 (12%) 1/28 (4%) 3/25 (12%) 3/23 (13%) | 16/30 (53%) 18/28 (64%) 11/35 (31%) 8/28 (29%) |
|FIRST INCIDENCE (DAYS) | 590 724 (T) 673 724 (T) | 597 597 605 549 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.590 P=0.094N P=0.612 P=0.401N | P<0.001N** P=0.538N P=0.008N** P=0.002N** |
|INCIDENTAL TUMOR | P=0.567N P=0.100N P=0.629 P=0.413N | P<0.001N** P=0.500N P=0.022N* P<0.001N** |
|LOGISTIC REGRESSION | P=0.546N P=0.100N P=0.624 P=0.350N | P<0.001N** P=0.448N P=0.050N* P<0.001N** |
|COCHRAN-ARMITAGE | P=0.551N | P<0.001N** |
|FISHER EXACT | P=0.102N P=0.630N P=0.357N | P=0.343N P=0.008N** P<0.001N** |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05033 TEST: 01 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.1% LM 1.0% MM 4.0% HM | CONTROL 0.1% LF 1.0% MF 4.0% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip) |
| Squamous Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 0.0% 0.0% 4.7% |
|TERMINAL (d) | 0/26 (0%) 0/28 (0%) 0/25 (0%) 0/23 (0%) | 0/30 (0%) 0/28 (0%) 0/35 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- --- --- 492 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.039 * (e) (e) P=0.227 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.035 * (e) (e) P=0.290 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.067 (e) (e) P=0.327 |
|COCHRAN-ARMITAGE | (e) | P=0.042 * |
|FISHER EXACT | (e) (e) (e) | (e) (e) P=0.247 |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Lip) |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 2.6% | 0.0% 0.0% 0.0% 4.7% |
|TERMINAL (d) | 0/26 (0%) 0/28 (0%) 0/25 (0%) 0/23 (0%) | 0/30 (0%) 0/28 (0%) 0/35 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 674 | --- --- --- 492 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.241 (e) (e) P=0.522 | P=0.039 * (e) (e) P=0.227 |
|INCIDENTAL TUMOR | P=0.312 (e) (e) P=0.576 | P=0.035 * (e) (e) P=0.290 |
|LOGISTIC REGRESSION | P=0.225 (e) (e) P=0.500 | P=0.067 (e) (e) P=0.327 |
|COCHRAN-ARMITAGE | P=0.224 | P=0.042 * |
|FISHER EXACT | (e) (e) P=0.500 | (e) (e) P=0.247 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05033 TEST: 01 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.1% LM 1.0% MM 4.0% HM | CONTROL 0.1% LF 1.0% MF 4.0% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Pancreas |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 2/50 (4%) 0/47 (0%) | 0/50 (0%) 0/49 (0%) 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 7.1% 6.5% 0.0% | 0.0% 0.0% 0.0% 3.6% |
|TERMINAL (d) | 0/26 (0%) 2/28 (7%) 1/25 (4%) 0/23 (0%) | 0/30 (0%) 0/28 (0%) 0/35 (0%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | --- 724 (T) 673 --- | --- --- --- 723 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.355N P=0.254 P=0.244 (e) | P=0.211 (e) (e) P=0.486 |
|INCIDENTAL TUMOR | P=0.330N P=0.254 P=0.235 (e) | P=0.211 (e) (e) P=0.486 |
|LOGISTIC REGRESSION | P=0.335N P=0.254 P=0.235 (e) | P=0.211 (e) (e) P=0.486 |
|COCHRAN-ARMITAGE | P=0.348N | P=0.226 |
|FISHER EXACT | P=0.247 P=0.247 (e) | (e) (e) P=0.500 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 14/46 (30%) 17/49 (35%) 19/50 (38%) 12/48 (25%) | 37/50 (74%) 31/49 (63%) 35/50 (70%) 27/49 (55%) |
|ADJUSTED (b) | 42.9% 45.4% 54.0% 34.5% | 80.3% 74.7% 77.5% 68.5% |
|TERMINAL (d) | 8/25 (32%) 9/27 (33%) 10/25 (40%) 3/23 (13%) | 21/30 (70%) 18/28 (64%) 25/35 (71%) 16/28 (57%) |
|FIRST INCIDENCE (DAYS) | 519 546 592 422 | 597 497 441 549 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.278N P=0.401 P=0.219 P=0.444N | P=0.166N P=0.382N P=0.218N P=0.157N |
|INCIDENTAL TUMOR | P=0.165N P=0.418 P=0.245 P=0.308N | P=0.074N P=0.232N P=0.564N P=0.072N |
|LOGISTIC REGRESSION | P=0.191N P=0.413 P=0.245 P=0.360N | P=0.073N P=0.197N P=0.441N P=0.062N |
|COCHRAN-ARMITAGE | P=0.192N | P=0.056N |
|FISHER EXACT | P=0.412 P=0.287 P=0.360N | P=0.175N P=0.412N P=0.039N* |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05033 TEST: 01 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.1% LM 1.0% MM 4.0% HM | CONTROL 0.1% LF 1.0% MF 4.0% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 14/46 (30%) 17/49 (35%) 19/50 (38%) 12/48 (25%) | 37/50 (74%) 32/49 (65%) 35/50 (70%) 28/49 (57%) |
|ADJUSTED (b) | 42.9% 45.4% 54.0% 34.5% | 80.3% 75.3% 77.5% 71.2% |
|TERMINAL (d) | 8/25 (32%) 9/27 (33%) 10/25 (40%) 3/23 (13%) | 21/30 (70%) 18/28 (64%) 25/35 (71%) 17/28 (61%) |
|FIRST INCIDENCE (DAYS) | 519 546 592 422 | 597 497 441 549 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.278N P=0.401 P=0.219 P=0.444N | P=0.198N P=0.447N P=0.218N P=0.199N |
|INCIDENTAL TUMOR | P=0.165N P=0.418 P=0.245 P=0.308N | P=0.094N P=0.296N P=0.564N P=0.106N |
|LOGISTIC REGRESSION | P=0.191N P=0.413 P=0.245 P=0.360N | P=0.093N P=0.253N P=0.441N P=0.094N |
|COCHRAN-ARMITAGE | P=0.192N | P=0.073N |
|FISHER EXACT | P=0.412 P=0.287 P=0.360N | P=0.235N P=0.412N P=0.060N |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 3/50 (6%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 7.7% 0.0% 12.0% 2.6% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/26 (8%) 0/28 (0%) 3/25 (12%) 0/23 (0%) | 0/30 (0%) 0/28 (0%) 0/35 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 724 (T) --- 724 (T) 676 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.632N P=0.221N P=0.482 P=0.516N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.601N P=0.221N P=0.482 P=0.485N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.589N P=0.221N P=0.482 P=0.495N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.586N | (e) |
|FISHER EXACT | P=0.247N P=0.500 P=0.500N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05033 TEST: 01 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.1% LM 1.0% MM 4.0% HM | CONTROL 0.1% LF 1.0% MF 4.0% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma, |
| Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 0/50 (0%) 4/50 (8%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 11.5% 0.0% 15.3% 2.6% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 3/26 (12%) 0/28 (0%) 3/25 (12%) 0/23 (0%) | 0/30 (0%) 0/28 (0%) 0/35 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 724 (T) --- 704 676 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.493N P=0.107N P=0.471 P=0.329N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.428N P=0.107N P=0.481 P=0.304N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.440N P=0.107N P=0.454 P=0.299N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.438N | (e) |
|FISHER EXACT | P=0.121N P=0.500 P=0.309N | (e) (e) (e) |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 1/50 (2%) 3/50 (6%) | 2/50 (4%) 3/50 (6%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 7.1% 3.0% 2.1% 8.8% | 6.3% 10.2% 2.1% 0.0% |
|TERMINAL (d) | 1/26 (4%) 0/28 (0%) 0/25 (0%) 1/23 (4%) | 1/30 (3%) 2/28 (7%) 0/35 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 717 704 555 574 | 718 704 521 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.241 P=0.480N P=0.525N P=0.476 | P=0.114N P=0.461 P=0.475N P=0.266N |
|INCIDENTAL TUMOR | P=0.282 P=0.553N P=0.479N P=0.504 | P=0.121N P=0.448 P=0.450N P=0.268N |
|LOGISTIC REGRESSION | P=0.265 P=0.489N P=0.502N P=0.500 | P=0.107N P=0.297 P=0.470N P=0.256N |
|COCHRAN-ARMITAGE | P=0.263 | P=0.107N |
|FISHER EXACT | P=0.500N P=0.500N P=0.500 | P=0.500 P=0.500N P=0.247N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05033 TEST: 01 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.1% LM 1.0% MM 4.0% HM | CONTROL 0.1% LF 1.0% MF 4.0% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Skin: Subcutaneous Tissue |
| Neurofibrosarcoma, Fibrosarcoma, Sarcoma, |
| Neurofibroma, or Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 2/50 (4%) 2/50 (4%) 4/50 (8%) | 2/50 (4%) 3/50 (6%) 2/50 (4%) 1/50 (2%) |
|ADJUSTED (b) | 8.9% 6.2% 5.0% 10.7% | 6.3% 10.2% 4.1% 2.0% |
|TERMINAL (d) | 1/26 (4%) 0/28 (0%) 0/25 (0%) 1/23 (4%) | 1/30 (3%) 2/28 (7%) 0/35 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 458 704 555 555 | 718 704 441 284 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.282 P=0.474N P=0.519N P=0.476 | P=0.314N P=0.461 P=0.672N P=0.527N |
|INCIDENTAL TUMOR | P=0.313 P=0.529N P=0.484N P=0.415 | P=0.234N P=0.448 P=0.607N P=0.268N |
|LOGISTIC REGRESSION | P=0.318 P=0.509N P=0.523N P=0.501 | P=0.195N P=0.297 P=0.608N P=0.339N |
|COCHRAN-ARMITAGE | P=0.304 | P=0.297N |
|FISHER EXACT | P=0.500N P=0.500N P=0.500 | P=0.500 P=0.691N P=0.500N |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 44/50 (88%) 43/46 (93%) 45/48 (94%) 45/50 (90%) | |
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% | |
|TERMINAL (d) | 26/26 (100%) 26/26 (100%) 24/24 (100%) 23/23 (100%)| |
|FIRST INCIDENCE (DAYS) | 573 509 420 555 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.252 P=0.477N P=0.341 P=0.335 | |
|INCIDENTAL TUMOR | P=0.598 P=0.295 P=0.321 P=0.481 | |
|LOGISTIC REGRESSION | P=0.617 P=0.226 P=0.218 P=0.521 | |
|COCHRAN-ARMITAGE | P=0.521N | |
|FISHER EXACT | P=0.287 P=0.264 P=0.500 | |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05033 TEST: 01 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.1% LM 1.0% MM 4.0% HM | CONTROL 0.1% LF 1.0% MF 4.0% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 1/17 (6%) 4/22 (18%) 1/49 (2%) | 6/50 (12%) 3/43 (7%) 4/47 (9%) 2/50 (4%) |
|ADJUSTED (b) | 12.1% 25.0% 31.8% 2.6% | 20.0% 12.5% 11.8% 6.4% |
|TERMINAL (d) | 1/26 (4%) 1/4 (25%) 1/4 (25%) 0/23 (0%) | 6/30 (20%) 3/24 (13%) 3/32 (9%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | 654 724 (T) 624 676 | 723 (T) 723 (T) 709 688 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.205N P=0.390N P=0.401 P=0.189N | P=0.179N P=0.358N P=0.325N P=0.154N |
|INCIDENTAL TUMOR | P=0.051N P=0.488 P=0.169 P=0.102N | P=0.176N P=0.358N P=0.356N P=0.161N |
|LOGISTIC REGRESSION | P=0.094N P=0.676 P=0.100 P=0.181N | P=0.171N P=0.358N P=0.351N P=0.161N |
|COCHRAN-ARMITAGE | P=0.127N | P=0.162N |
|FISHER EXACT | P=0.625N P=0.192 P=0.187N | P=0.324N P=0.410N P=0.134N |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/17 (12%) 1/22 (5%) 0/49 (0%) | 2/50 (4%) 3/43 (7%) 2/47 (4%) 1/50 (2%) |
|ADJUSTED (b) | 3.8% 26.5% 3.0% 0.0% | 5.6% 12.5% 5.7% 3.6% |
|TERMINAL (d) | 1/26 (4%) 1/4 (25%) 0/4 (0%) 0/23 (0%) | 1/30 (3%) 3/24 (13%) 1/32 (3%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | 724 (T) 509 684 --- | 660 723 (T) 707 723 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.178N P=0.145 P=0.592 P=0.524N | P=0.294N P=0.408 P=0.666N P=0.528N |
|INCIDENTAL TUMOR | P=0.155N P=0.176 P=0.465 P=0.524N | P=0.286N P=0.372 P=0.634 P=0.537N |
|LOGISTIC REGRESSION | P=0.153N P=0.162 P=0.454 P=0.524N | P=0.283N P=0.372 P=0.669 P=0.521N |
|COCHRAN-ARMITAGE | P=0.153N | P=0.271N |
|FISHER EXACT | P=0.156 P=0.521 P=0.505N | P=0.428 P=0.668 P=0.500N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05033 TEST: 01 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.1% LM 1.0% MM 4.0% HM | CONTROL 0.1% LF 1.0% MF 4.0% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 3/17 (18%) 4/22 (18%) 1/49 (2%) | 8/50 (16%) 6/43 (14%) 6/47 (13%) 3/50 (6%) |
|ADJUSTED (b) | 15.6% 51.0% 31.8% 2.6% | 25.2% 25.0% 17.1% 9.9% |
|TERMINAL (d) | 2/26 (8%) 2/4 (50%) 1/4 (25%) 0/23 (0%) | 7/30 (23%) 6/24 (25%) 4/32 (13%) 2/28 (7%) |
|FIRST INCIDENCE (DAYS) | 654 509 624 676 | 660 723 (T) 707 688 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.075N P=0.516 P=0.443 P=0.116N | P=0.095N P=0.561N P=0.334N P=0.123N |
|INCIDENTAL TUMOR | P=0.018N* P=0.102 P=0.208 P=0.060N | P=0.091N P=0.585N P=0.413N P=0.129N |
|LOGISTIC REGRESSION | P=0.030N* P=0.218 P=0.140 P=0.103N | P=0.087N P=0.609 P=0.408N P=0.127N |
|COCHRAN-ARMITAGE | P=0.040N* | P=0.082N |
|FISHER EXACT | P=0.326 P=0.273 P=0.107N | P=0.508N P=0.436N P=0.100N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 0/17 (0%) 0/22 (0%) 2/49 (4%) | 0/50 (0%) 0/43 (0%) 0/47 (0%) 1/50 (2%) |
|ADJUSTED (b) | 3.8% 0.0% 0.0% 4.9% | 0.0% 0.0% 0.0% 3.6% |
|TERMINAL (d) | 1/26 (4%) 0/4 (0%) 0/4 (0%) 0/23 (0%) | 0/30 (0%) 0/24 (0%) 0/32 (0%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | 724 (T) --- --- 626 | --- --- --- 723 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.237 P=0.860N P=0.860N P=0.501 | P=0.224 (e) (e) P=0.486 |
|INCIDENTAL TUMOR | P=0.282 P=0.860N P=0.860N P=0.476 | P=0.224 (e) (e) P=0.486 |
|LOGISTIC REGRESSION | P=0.303 P=0.860N P=0.860N P=0.491 | P=0.224 (e) (e) P=0.486 |
|COCHRAN-ARMITAGE | P=0.290 | P=0.237 |
|FISHER EXACT | P=0.746N P=0.694N P=0.492 | (e) (e) P=0.500 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05033 TEST: 01 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.1% LM 1.0% MM 4.0% HM | CONTROL 0.1% LF 1.0% MF 4.0% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Tongue |
| Squamous Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 0.0% 0.0% 0.0% 4.7% |
|TERMINAL (d) | 0/26 (0%) 0/28 (0%) 0/25 (0%) 0/23 (0%) | 0/30 (0%) 0/28 (0%) 0/35 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | --- --- --- 492 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.039 * (e) (e) P=0.227 |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.035 * (e) (e) P=0.290 |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.067 (e) (e) P=0.327 |
|COCHRAN-ARMITAGE | (e) | P=0.042 * |
|FISHER EXACT | (e) (e) (e) | (e) (e) P=0.247 |
|=================================================================================================================================|
| |
|Tongue |
| Squamous Cell Carcinoma or Papilloma Squamous |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 2.6% | 0.0% 0.0% 0.0% 4.7% |
|TERMINAL (d) | 0/26 (0%) 0/28 (0%) 0/25 (0%) 0/23 (0%) | 0/30 (0%) 0/28 (0%) 0/35 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- 674 | --- --- --- 492 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.241 (e) (e) P=0.522 | P=0.039 * (e) (e) P=0.227 |
|INCIDENTAL TUMOR | P=0.312 (e) (e) P=0.576 | P=0.035 * (e) (e) P=0.290 |
|LOGISTIC REGRESSION | P=0.225 (e) (e) P=0.500 | P=0.067 (e) (e) P=0.327 |
|COCHRAN-ARMITAGE | P=0.224 | P=0.042 * |
|FISHER EXACT | (e) (e) P=0.500 | (e) (e) P=0.247 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05033 TEST: 01 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.1% LM 1.0% MM 4.0% HM | CONTROL 0.1% LF 1.0% MF 4.0% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 7/50 (14%) 9/50 (18%) 16/50 (32%) 11/50 (22%) |
|ADJUSTED (b) | | 18.8% 27.7% 41.4% 33.2% |
|TERMINAL (d) | | 4/30 (13%) 6/28 (21%) 13/35 (37%) 8/28 (29%) |
|FIRST INCIDENCE (DAYS) | | 597 515 521 284 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.261 P=0.334 P=0.059 P=0.178 |
|INCIDENTAL TUMOR | | P=0.333 P=0.422 P=0.035 * P=0.312 |
|LOGISTIC REGRESSION | | P=0.310 P=0.399 P=0.028 * P=0.265 |
|COCHRAN-ARMITAGE | | P=0.314 |
|FISHER EXACT | | P=0.393 P=0.028 * P=0.218 |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 0/50 (0%) 2/50 (4%) 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | | 0.0% 4.8% 2.9% 0.0% |
|TERMINAL (d) | | 0/30 (0%) 0/28 (0%) 1/35 (3%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | | --- 543 723 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.354N P=0.229 P=0.531 (e) |
|INCIDENTAL TUMOR | | P=0.370N P=0.350 P=0.531 (e) |
|LOGISTIC REGRESSION | | P=0.315N P=0.280 P=0.531 (e) |
|COCHRAN-ARMITAGE | | P=0.343N |
|FISHER EXACT | | P=0.247 P=0.500 (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05033 TEST: 01 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.1% LM 1.0% MM 4.0% HM | CONTROL 0.1% LF 1.0% MF 4.0% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # # # |
|----------- | | |
|OVERALL (a) | | 7/50 (14%) 11/50 (22%) 17/50 (34%) 11/50 (22%) |
|ADJUSTED (b) | | 18.8% 31.2% 44.0% 33.2% |
|TERMINAL (d) | | 4/30 (13%) 6/28 (21%) 14/35 (40%) 8/28 (29%) |
|FIRST INCIDENCE (DAYS) | | 597 515 521 284 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.360 P=0.182 P=0.040 * P=0.178 |
|INCIDENTAL TUMOR | | P=0.433 P=0.281 P=0.023 * P=0.312 |
|LOGISTIC REGRESSION | | P=0.424 P=0.246 P=0.017 * P=0.265 |
|COCHRAN-ARMITAGE | | P=0.420 |
|FISHER EXACT | | P=0.218 P=0.017 * P=0.218 |
|=================================================================================================================================|
| |
|Zymbal's Gland |
| Squamous Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) | 1/50 (2%) 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 0.0% 0.0% | 2.4% 6.3% 0.0% 0.0% |
|TERMINAL (d) | 0/26 (0%) 0/28 (0%) 0/25 (0%) 0/23 (0%) | 0/30 (0%) 0/28 (0%) 0/35 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- --- --- | 660 683 --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) (e) (e) | P=0.228N P=0.458 P=0.495N P=0.520N |
|INCIDENTAL TUMOR | (e) (e) (e) (e) | P=0.238N P=0.434 P=0.581N P=0.536N |
|LOGISTIC REGRESSION | (e) (e) (e) (e) | P=0.221N P=0.506 P=0.486N P=0.481N |
|COCHRAN-ARMITAGE | (e) | P=0.223N |
|FISHER EXACT | (e) (e) (e) | P=0.500 P=0.500N P=0.500N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05033 TEST: 01 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.1% LM 1.0% MM 4.0% HM | CONTROL 0.1% LF 1.0% MF 4.0% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 2/50 (4%) 0/50 (0%) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% 6.7% 0.0% | 2.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/26 (0%) 0/28 (0%) 1/25 (4%) 0/23 (0%) | 0/30 (0%) 0/28 (0%) 0/35 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- 674 --- | 422 --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.667N (e) P=0.239 (e) | P=0.558N P=0.500N P=0.504N P=0.504N |
|INCIDENTAL TUMOR | P=0.615N (e) P=0.235 (e) | P=0.587N P=0.227N P=0.362N P=0.362N |
|LOGISTIC REGRESSION | P=0.661N (e) P=0.235 (e) | P=0.318N P=0.227N P=0.249N P=0.231N |
|COCHRAN-ARMITAGE | P=0.661N | P=0.555N |
|FISHER EXACT | (e) P=0.247 (e) | P=0.500N P=0.500N P=0.500N |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, |
| or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 16/50 (32%) 18/50 (36%) 22/50 (44%) 13/50 (26%) | 9/50 (18%) 10/50 (20%) 13/50 (26%) 12/50 (24%) |
|ADJUSTED (b) | 42.4% 39.2% 58.8% 42.5% | 22.8% 26.3% 29.6% 32.6% |
|TERMINAL (d) | 6/26 (23%) 2/28 (7%) 11/25 (44%) 7/23 (30%) | 3/30 (10%) 3/28 (11%) 5/35 (14%) 5/28 (18%) |
|FIRST INCIDENCE (DAYS) | 590 546 549 662 | 422 504 548 623 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.257N P=0.470 P=0.168 P=0.393N | P=0.285 P=0.423 P=0.323 P=0.264 |
|INCIDENTAL TUMOR | P=0.138N P=0.360 P=0.183 P=0.286N | P=0.304 P=0.607 P=0.105 P=0.296 |
|LOGISTIC REGRESSION | P=0.167N P=0.334 P=0.151 P=0.274N | P=0.353 P=0.597N P=0.258 P=0.331 |
|COCHRAN-ARMITAGE | P=0.164N | P=0.322 |
|FISHER EXACT | P=0.417 P=0.151 P=0.330N | P=0.500 P=0.235 P=0.312 |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05033 TEST: 01 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.1% LM 1.0% MM 4.0% HM | CONTROL 0.1% LF 1.0% MF 4.0% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 2/50 (4%) 2/50 (4%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 8.3% 5.5% 6.2% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/26 (0%) 1/28 (4%) 1/25 (4%) 0/23 (0%) | 0/30 (0%) 0/28 (0%) 0/35 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 654 458 592 --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.117N P=0.488N P=0.514N P=0.118N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.101N P=0.529N P=0.483N P=0.060N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.102N P=0.533N P=0.502N P=0.121N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.107N | (e) |
|FISHER EXACT | P=0.500N P=0.500N P=0.121N | (e) (e) (e) |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, |
| NOS, or Undifferentiated Cell Type |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 2/50 (4%) 2/50 (4%) 0/50 (0%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 8.3% 5.5% 6.2% 0.0% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/26 (0%) 1/28 (4%) 1/25 (4%) 0/23 (0%) | 0/30 (0%) 0/28 (0%) 0/35 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 654 458 592 --- | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.117N P=0.488N P=0.514N P=0.118N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.101N P=0.529N P=0.483N P=0.060N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.102N P=0.533N P=0.502N P=0.121N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.107N | (e) |
|FISHER EXACT | P=0.500N P=0.500N P=0.121N | (e) (e) (e) |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05033 TEST: 01 PAGE 22
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.1% LM 1.0% MM 4.0% HM | CONTROL 0.1% LF 1.0% MF 4.0% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 4/50 (8%) 3/50 (6%) 1/50 (2%) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 10.8% 11.8% 6.9% 3.6% | 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/26 (4%) 2/28 (7%) 0/25 (0%) 0/23 (0%) | 0/30 (0%) 0/28 (0%) 0/35 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 573 599 420 704 | --- --- --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.133N P=0.626N P=0.501N P=0.192N | (e) (e) (e) (e) |
|INCIDENTAL TUMOR | P=0.133N P=0.640N P=0.451N P=0.194N | (e) (e) (e) (e) |
|LOGISTIC REGRESSION | P=0.111N P=0.635 P=0.534N P=0.179N | (e) (e) (e) (e) |
|COCHRAN-ARMITAGE | P=0.120N | (e) |
|FISHER EXACT | P=0.643N P=0.500N P=0.181N | (e) (e) (e) |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 49/50 (98%) 48/50 (96%) 50/50 (100%) 48/50 (96%) | 49/50 (98%) 44/50 (88%) 42/50 (84%) 35/50 (70%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% | 98.0% 93.6% 87.5% 84.9% |
|TERMINAL (d) | 26/26 (100%) 28/28 (100%) 25/25 (100%) 23/23 (100%)| 29/30 (97%) 25/28 (89%) 29/35 (83%) 22/28 (79%) |
|FIRST INCIDENCE (DAYS) | 226 509 420 422 | 422 497 441 284 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.340 P=0.359N P=0.413 P=0.467 | P=0.052N P=0.503N P=0.041N* P=0.060N |
|INCIDENTAL TUMOR | P=0.659N P=0.616N P=0.500 P=0.599N | P<0.001N** P=0.103N P=0.039N* P<0.001N** |
|LOGISTIC REGRESSION | P=0.643 P=0.307N P=0.627 P=0.612N | P<0.001N** P=0.073N P=0.021N* P<0.001N** |
|COCHRAN-ARMITAGE | P=0.464N | P<0.001N** |
|FISHER EXACT | P=0.500N P=0.500 P=0.500N | P=0.056N P=0.015N* P<0.001N** |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05033 TEST: 01 PAGE 23
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
TERMINAL SACRIFICE AT 104 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | CONTROL 0.1% LM 1.0% MM 4.0% HM | CONTROL 0.1% LF 1.0% MF 4.0% HF |
| | UM | UF |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 29/50 (58%) 27/50 (54%) 32/50 (64%) 21/50 (42%) | 15/50 (30%) 19/50 (38%) 19/50 (38%) 20/50 (40%) |
|ADJUSTED (b) | 64.9% 54.7% 73.5% 57.0% | 36.4% 44.0% 42.5% 46.1% |
|TERMINAL (d) | 11/26 (42%) 6/28 (21%) 14/25 (56%) 9/23 (39%) | 6/30 (20%) 6/28 (21%) 10/35 (29%) 6/28 (21%) |
|FIRST INCIDENCE (DAYS) | 458 458 420 422 | 422 497 441 284 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.170N P=0.392N P=0.339 P=0.177N | P=0.253 P=0.214 P=0.396 P=0.175 |
|INCIDENTAL TUMOR | P=0.048N* P=0.401N P=0.403 P=0.087N | P=0.281 P=0.394 P=0.153 P=0.231 |
|LOGISTIC REGRESSION | P=0.074N P=0.438N P=0.340 P=0.100N | P=0.357 P=0.419 P=0.284 P=0.288 |
|COCHRAN-ARMITAGE | P=0.050N* | P=0.283 |
|FISHER EXACT | P=0.420N P=0.341 P=0.081N | P=0.263 P=0.263 P=0.201 |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # | # # # # |
|----------- | | |
|OVERALL (a) | 50/50 (100%) 50/50 (100%) 50/50 (100%) 48/50 (96%) | 49/50 (98%) 48/50 (96%) 43/50 (86%) 45/50 (90%) |
|ADJUSTED (b) | 100.0% 100.0% 100.0% 100.0% | 98.0% 96.0% 87.8% 93.7% |
|TERMINAL (d) | 26/26 (100%) 28/28 (100%) 25/25 (100%) 23/23 (100%)| 29/30 (97%) 26/28 (93%) 29/35 (83%) 25/28 (89%) |
|FIRST INCIDENCE (DAYS) | 226 458 420 422 | 422 497 441 284 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.427 P=0.419N P=0.470 P=0.523 | P=0.494N P=0.374 P=0.059N P=0.541N |
|INCIDENTAL TUMOR | P=0.268N (e) (e) P=0.362N | P=0.154N P=0.476N P=0.084N P=0.112N |
|LOGISTIC REGRESSION | P=0.058N (e) (e) P=0.162N | P=0.189N P=0.476N P=0.035N* P=0.107N |
|COCHRAN-ARMITAGE | P=0.042N* | P=0.138N |
|FISHER EXACT | P=1.000N P=1.000N P=0.247N | P=0.500N P=0.030N* P=0.102N |
|=================================================================================================================================|
DATE: 09/04/94 EXPERIMENT: 05033 TEST: 01 PAGE 24
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- QUERCETIN
TERMINAL SACRIFICE AT 104 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).